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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>A Perspective on Mature Gratitude as a Way of Coping with COVID-19</strong> -
<div>
Aim and Method: This perspective searches presents evidence of mature gratitude as a way of coping with the threats and boundaries of COVID-19. This narrative, non-systematic review will be based on studies from the COVID-19 period in association with more general literature on the characteristics of mature gratitude related to good mental health. Results: The results from the literature suggest that a confrontation with our existential vulnerability during a pandemic is not only a crisis but also an opportunity to view our lives in a different way. Mature gratitude, as proposed in this perspective, can help us in coping with the threats and boundaries that are part of our lives due to the COVID-19 pandemic. This time of crisis gives us the opportunity to self-reflect on our current life and plans for the future and to reframe them through a positive lens which can encourage individuals to actively strengthen their psychological resilience and coping skills. Conclusion: Cultivating an attitude of mature gratitude through actions of kindness, expressing being thankful for life and God, and enjoying all the small things in life helps in coping with the current threats of COVID-19 and building lifelong resilience for the future Knowledge about these associations can help psychologists, counselors, and coaches to support people who experience psychological issues due to the current pandemic and all crises to come.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/b9zq4/" target="_blank">A Perspective on Mature Gratitude as a Way of Coping with COVID-19</a>
</div></li>
<li><strong>Temporal Distancing during the COVID-19 pandemic: Letter Writing with Future Self can Mitigate Negative Affect</strong> -
<div>
Novel coronavirus disease (COVID-19) is spreading across the world, threatening not only physical health but also psychological well-being. We reasoned that a broadened temporal perspective may attenuate current mental distress and tested a letter-writing manipulation designed to connect people to their post-COVID-19 future selves. Participants were randomly assigned to either send a letter to their future self (letter-to-future), send a letter to present self from the perspective of future self (letter-from-future), or a control condition. Participants in both letter-writing conditions showed immediate decrease in negative affect and increase in positive affect relative to the control condition. These effects were mediated by temporal distancing from the current situation. These findings suggest that taking a broader temporal perspective can be achieved by letter-writing with a future self and may offer an effective means of regulating negative affect in a stressful present time such as the COVID-19 pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/gr86d/" target="_blank">Temporal Distancing during the COVID-19 pandemic: Letter Writing with Future Self can Mitigate Negative Affect</a>
</div></li>
<li><strong>Negative shocks predict change in cognitive function and preferences: Assessing the negative affect and stress hypothesis in the context of the COVID-19 crisis</strong> -
<div>
In the context of the current COVID-19 pandemic, households throughout the world have to cope with negative shocks, either because of the disease or the various mitigation strategies that have caused massive unemployment and financial insecurity. Previous research has shown that negative shocks impair cognitive function and change risk, time and social preferences. In this study, we analyze the results of a longitudinal multi-country survey conducted in Italy (N=1,652), Spain (N=1,660) and the United Kingdom (N=1,578). We measure cognitive function using the Cognitive Reflection Test and preferences traits using an experimentally validated set of questions to assess the differences between people exposed to a shock compared to the rest of the sample. We measure four possible types of shocks: labor market shock, health shock, occurrence of stressful events, and mental health shock. Additionally, we randomly assign participants to groups with either a recall of negative events (more specifically, a mild reinforcement of stress or of fear/anxiety), or to a control group (to recall neutral or joyful memories), in order to assess whether or not stress and negative emotions drive a change in preferences. Results show that people affected by shocks performed worse in terms of cognitive functioning, are more risk loving, and are more prone to punish others (negative reciprocity). Data do not support the hypotheses that the result is driven by stress or by negative emotions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/qhkf9/" target="_blank">Negative shocks predict change in cognitive function and preferences: Assessing the negative affect and stress hypothesis in the context of the COVID-19 crisis</a>
</div></li>
<li><strong>Assessment supervision during COVID-19 and beyond: Trainee perspectives on the supervision of teleassessment</strong> -
<div>
Due to COVID-19, there has been a rapid shift toward the remote administration of psychological assessments, or teleassessment. Guidelines have been published by the American Psychological Association regarding best practices for teleassessment administration, yet there is limited guidance for the clinical supervision of trainees. Quality supervision is a core competency of health service psychologists, and critical to the professional development of practitioners, as well as the protection of patients. This article reviews the extant literature on teleassessment and makes practice-informed recommendations to enhance the supervision of teleassessment administration. Implications for training in teleassessment during the COVID-19 pandemic as well as the development of clinical training competencies in teleassessment are considered.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/ghqck/" target="_blank">Assessment supervision during COVID-19 and beyond: Trainee perspectives on the supervision of teleassessment</a>
</div></li>
<li><strong>A systematic review on sex- and gender-sensitive research in public mental health during the first wave of the COVID-19 crisis</strong> -
<div>
Background Sex and gender are important modifiers of mental health and behavior in normal times and during crises. We investigated whether they were addressed by empirical, international research which explored the mental health and health behavior ramifications after the onset of the COVID-19 pandemic. Methods We systematically searched the databases PsyArXiv, PubMed, PsycInfo, Psyndex, PubPsych, Cochrane Library, and Web of Science for studies assessing mental health outcomes (main outcomes) as well as potential risk and protective health behavior (additional outcomes) up to July 2, 2020. Findings Most of the 80 publications fulfilling the selection criteria reflected the static difference perspective treating sex and gender as dichotomous variables. The focus was on internalizing disorders (esp. anxiety and depression) burdening women in particular, while externalizing disorders were neglected. Sex- and gender-specific evaluation of mental health care use has also been lacking. With respect to unfavorable health behavior in terms of adherence to prescribed protective measures, men constitute a risk group. Interpretations Women remain a vulnerable group burdened by multiple stresses and mental health symptoms. The neglect of sex and gender-specific evaluation of aggression-related disorders, substance addiction, and mental health care use in the early stage represents a potentially dangerous oversight.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/cbsj6/" target="_blank">A systematic review on sex- and gender-sensitive research in public mental health during the first wave of the COVID-19 crisis</a>
</div></li>
<li><strong>Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background. Neurological and psychiatric sequelae of COVID-19 have been reported, but there are limited data on incidence rates and relative risks. Methods. Using retrospective cohort studies and time-to-event analysis, we estimated the incidence of ICD-10 diagnoses in the 6 months after a confirmed diagnosis of COVID-19: intracranial haemorrhage; ischaemic stroke; Parkinsonism; Guillain-Barre syndrome; nerve/nerve root/plexus disorders; myoneural/muscle disease; encephalitis; dementia; mood, anxiety, and psychotic disorders; substance misuse; and insomnia. Data were obtained from the TriNetX electronic health records network (over 81 million patients). We compared incidences with those in propensity score-matched cohorts of patients with influenza or other respiratory infections using a Cox model. We investigated the effect on incidence estimates of COVID-19 severity, as proxied by hospitalization and encephalopathy (including delirium and related disorders). Findings. 236,379 patients survived a confirmed diagnosis of COVID-19. Among them, the estimated incidence of neurological or psychiatric sequelae at 6 months was 33.6%, with 12.8% receiving their first such diagnosis. Most diagnostic categories were commoner after COVID-19 than after influenza or other respiratory infections (hazard ratios from 1.21 to 5.28), including stroke, intracranial haemorrhage, dementia, and psychotic disorders. Findings were equivocal for Parkinsonism and Guillain-Barre syndrome. Amongst COVID-19 cases, incidences and hazard ratios for most disorders were higher in patients who had been hospitalized, and markedly so in those who had experienced encephalopathy. Results were robust to sensitivity analyses, including comparisons against an additional four index health events. Interpretation. The study provides evidence for substantial neurological and psychiatric morbidity following COVID-19 infection. Risks were greatest in, but not limited to, those who had severe COVID-19. The information can help in service planning and identification of research priorities.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.16.21249950v1" target="_blank">Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19</a>
</div></li>
<li><strong>Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant</strong> -
<div>
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide and massive societal and economic burden. Recently, a new variant of SARS-CoV-2, known as B.1.1.7, was first detected in the United Kingdom and is spreading in several other countries, heightening public health concern and raising questions as to the resulting effectiveness of vaccines and therapeutic interventions. We and others previously identified host-directed therapies with antiviral efficacy against SARS-CoV-2 infection. Less prone to the development of therapy resistance, host-directed drugs represent promising therapeutic options to combat emerging viral variants as host genes possess a lower propensity to mutate compared to viral genes. Here, in the first study of the full-length B.1.1.7 variant virus, we find two host-directed drugs, plitidepsin (aplidin; inhibits translation elongation factor eEF1A) and ralimetinib (inhibits p38 MAP kinase cascade), as well as remdesivir, to possess similar antiviral activity against both the early-lineage SARS-CoV-2 and the B.1.1.7 variant, evaluated in both human gastrointestinal and lung epithelial cell lines. We find that plitidepsin is over an order of magnitude more potent than remdesivir against both viruses. These results highlight the importance of continued development of host-directed therapeutics to combat current and future coronavirus variant outbreaks.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.24.427991v1" target="_blank">Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant</a>
</div></li>
<li><strong>An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19</strong> -
<div>
COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells. DS-autoAg complexes are capable of stimulating autoreactive B cells and autoantibody production. Using DS affinity, we identified an autoantigenome of 408 proteins from human fetal lung fibroblast HFL11 cells, at least 231 of which are known autoAgs. Comparing with available COVID data, 352 proteins of the autoantigenome have thus far been found to be altered at protein or RNA levels in SARS-Cov-2 infection, 210 of which are known autoAgs. The COVID-altered proteins are significantly associated with RNA metabolism, translation, vesicles and vesicle transport, cell death, supramolecular fibrils, cytoskeleton, extracellular matrix, and interleukin signaling. They offer clues to neurological problems, fibrosis, smooth muscle dysfunction, and thrombosis. In particular, 150 altered proteins are related to the nervous system, including axon, myelin sheath, neuron projection, neuronal cell body, and olfactory bulb. An association with the melanosome is also identified. The findings from our study illustrate a strong connection between viral infection and autoimmunity. The vast number of COVID-altered proteins with propensity to become autoAgs offers an explanation for the diverse autoimmune complications in COVID patients. The variety of autoAgs related to mRNA metabolism, translation, and vesicles raises concerns about potential adverse effects of mRNA vaccines. The COVID autoantigen atlas we are establishing provides a detailed molecular map for further investigation of autoimmune sequelae of the pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.24.427965v1" target="_blank">An Autoantigen Atlas from Human Lung HFL1 Cells Offers Clues to Neurological and Diverse Autoimmune Manifestations of COVID-19</a>
</div></li>
<li><strong>Meta-analysis reveals consistent immune response patterns in COVID-19 infected patients at single-cell resolution</strong> -
<div>
A number of single-cell RNA studies looking at the human immune response to the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been recently published. However, the number of samples used in each individual study typically is small, moreover the technologies and protocols used in different studies vary, thus somewhat restricting the range of conclusions that can be made with high confidence. To better capture the cellular gene expression changes upon SARS-CoV-2 infection at different levels and stages of disease severity and to minimise the effect of technical artefacts, we performed meta-analysis of data from 9 previously published studies, together comprising 143 human samples, and a set of 16 healthy control samples (10X). In particular, we used generally accepted immune cell markers to discern specific cell subtypes and to look at the changes of the cell proportion over different disease stages and their consistency across the studies. While half of the observations reported in the individual studies can be confirmed across multiple studies, half of the results seem to be less conclusive. In particular, we show that the differentially expressed genes consistently point to upregulation of type I Interferon signal pathway and downregulation of the mitochondrial genes, alongside several other reproducibly consistent changes. We also confirm the presence of expanded B-cell clones in COVID-19 patients, however, no consistent trend in T-cell clonal expansion was observed.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.24.427089v1" target="_blank">Meta-analysis reveals consistent immune response patterns in COVID-19 infected patients at single-cell resolution</a>
</div></li>
<li><strong>Variation analysis of SARS-CoV-2 complete sequences from Iran</strong> -
<div>
The SARS-CoV-2 is a new emerging coronavirus initially reported in China in late December 2019 and rapidly spread to the whole of the world. To date, 1261903 total cases and 55830 deaths are reported from Iran as of 8 January. In this study, we investigated all the complete sequences of SARS-CoV-2 that publicly reported from Iran. Twenty-four sequences between March to September 2020 were analyzed to identify genome variations and phylogenetic relationships. Furthermore, we assessed the amino acid changes related to the spike glycoprotein as an important viral factor associated with the entry to the host cells and as a vaccine target. Most of the variations occur in the ORF1ab, S, N, intergenic, and ORF7 regions. The analysis of spike protein mutations demonstrated that the D614G mutation could be detected from May and beyond. Phylogenetic analysis showed that most of the circulated viruses in Iran are belong to the B.4 lineage. Although, we found a limited number of variants associated with the B.1 lineage carrying D614G mutation. Furthermore, we detected a variant characterize as the B.1.36 lineage with sixteen mutations in the spike protein region. This study showed the frequency of the viral populations in Iran as of September, therefore, there is an emergent need for genomic surveillance to track viral lineage shift in the country beyond September. These data would help to predict the future situation and apply better strategies to control the pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.23.427885v1" target="_blank">Variation analysis of SARS-CoV-2 complete sequences from Iran</a>
</div></li>
<li><strong>GIS-Based Analysis Framework for Identifying COVID-19 Incidence and Fatality Determinants at National Level Case study: Africa</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Abstract Background: COVID-19 pandemic is an extraordinary threat with significant implications in all aspects of human life, therefore, it represents the most immediate challenges for all countries all over the world. Objectives: This study is intended to develop a GIS-based analysis model to explore, quantify and model the relationships between COVID-19 morbidity and mortality and their potential predictor variables. Method: For this purpose, a model was developed to estimate COVID-19 incidence and fatality rates in Africa up to 16th of August 2020 at the national level. The model involved Ordinary Least Squares (OLS) and Geographically Weighted Regression (GWR) analysis through ArcGIS was applied. Result: Spatial Autocorrelation Analysis revealed that there was positive spatial autocorrelation in COVID-19 incidence (Moran index 0.16. P value &lt;0.1), and fatality (Moran index 0.0.35, P value&lt;0.01) rates within different African countries. At continental level, OLS revealed that COVID-19 incidence rate was found to be positively associated with overcrowding, health expenditure, HIV infections and air pollution and negatively associated with BCG vaccine (β=2.97,1.45, 0.01, 3.29, -47.65 respectively, P&lt; 0.05) At the same time, COVID-19 fatality was found to be positively related to asthma prevalence and tobacco use. Yet, certain level of inconsistency was noted in the case of COVID-19 fatality, which was negatively related to elder population, poverty, and cardiovascular mortality (P&lt;0.05). This model showed convenient level of validity in modeling the relationship between COVID-19 incidence as well as fatality and their key predictors using GWR. In this respect, the model explained about 58% and 55% of the variance in COVID-19 incidence and fatality rates, respectively, as a function of considered predictors. Conclusion: Application of the suggested model can assist in guiding intervention strategies, particularly in case of local and community level whenever the data on COVID-19 cases and predictors variables are available.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.12.21249661v2" target="_blank">GIS-Based Analysis Framework for Identifying COVID-19 Incidence and Fatality Determinants at National Level Case study: Africa</a>
</div></li>
<li><strong>Determinants of COVID-19 Incidence and Mortality in the US: Spatial Analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
<b>OBJECTIVES:</b> The US continues to account for the highest proportion of the global Coronavirus Disease-2019 (COVID-19) cases and deaths. Currently, it is important to contextualize the spread and success of mitigation efforts. The objective of this study was to assess the ecological determinants (policy, health behaviors, socio-economic, physical environment, and clinical care) of COVID-19 incidence and mortality in the US. <b> METHODS:</b> Data from the New York Times COVID-19 repository (01/21/2020-10/27/2020), 2020 County Health Rankings, 2016 County Presidential Election Returns, and 2018-2019 Area Health Resource File were used. County-level logged incidence and mortality rate/million were modeled using the Spatial Autoregressive Combined model and spatial lag model. <b>RESULTS:</b> Counties with higher proportions of racial minorities (African American β= 0.007, Native Americans β= 0.008, Hispanics β= 0.015), non-English speakers (β= 0.010), population density ([logged] β= 0.028), and air pollution (β= 0.062) were significantly associated with high COVID-19 incidence rates. Subsequently, counties with higher Republican voters (β= 0.017), excessive drinkers (β= 0.107), children in single-parent households (β= 0.018), uninsured adults (β= 0.038), racial minorities (African American β= 0.032, Native Americans β= 0.034, Hispanics β= 0.037), females (β= 0.101), and population density ([logged] β= 0.270), air pollution (β= 0.130), and non-Whites/Whites residential segregation (β= 0.014) were significantly associated with high COVID-19 mortality rates. Additionally, longer state-level restrictions were associated with lower COVID-19 incidence and mortality rates. <b>CONCLUSION:</b> The spatial models identified longer state-level restrictions, population density, air pollution, uninsured rate, and race/ethnicity as important determinants of the geographic disparities in COVID-19 incidence and mortality.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.02.20242685v2" target="_blank">Determinants of COVID-19 Incidence and Mortality in the US: Spatial Analysis</a>
</div></li>
<li><strong>In silico investigation of the new UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 variants with a focus at the ACE2-Spike RBD interface</strong> -
<div>
SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have higher transmission capabilities, eventually due to amino acid substitutions on the SARS-CoV-2 Spike protein. The pathogenicity seems modified but is still under investigation. Here we used the experimental structure of the Spike RBD domain co-crystallized with part of the ACE2 receptor and several in silico methods to analyze the possible impacts of three amino acid replacements (Spike K417N, E484K, N501Y) with regard to ACE2 binding. We found that the N501Y replacement in this region of the interface (present in both UK and South African strains) should be favorable for the interaction with ACE2 while the K417N and E484K substitutions (South African) would seem unfavorable. It is unclear if the N501Y substitution in the South African strain could counterbalance the predicted less favorable (regarding binding) K417N and E484K Spike replacements. Our finding suggests that, if indeed the South African strain has a high transmission level, this could be due to the N501Y replacement and/or to substitutions in regions outside the direct Spike-ACE2 interface.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.01.24.427939v1" target="_blank">In silico investigation of the new UK (B.1.1.7) and South African (501Y.V2) SARS-CoV-2 variants with a focus at the ACE2-Spike RBD interface</a>
</div></li>
<li><strong>Tool for estimating the probability of having COVID-19 with one or more negative RT-PCR results</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Early case detection and isolation of infected individuals are critical to controlling COVID-19. RT-PCR is considered the diagnosis gold standard, but false-negatives occur. Based on previous work, we built a user-friendly online tool to estimate the probability of having COVID-19 with negative RT-PCR results and thus avoid preventable SARS-CoV-2 transmission.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.16.21249939v1" target="_blank">Tool for estimating the probability of having COVID-19 with one or more negative RT-PCR results</a>
</div></li>
<li><strong>Artificial Intelligence for Emotion-Semantic Trending and People Emotion Detection During COVID-19 Social Isolation</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Taking advantage of social media platforms, such as Twitter, this paper provides an effective framework for emotion detection among those who are quarantined. Early detection of emotional feelings and their trends help implement timely intervention strategies. Given the limitations of medical diagnosis of early emotional change signs during the quarantine period, artificial intelligence models provide effective mechanisms in uncovering early signs, symptoms and escalating trends. Novelty of the approach presented herein is a multitask methodological framework of text data processing, implemented as a pipeline for meaningful emotion detection and analysis, based on the Plutchik/Ekman approach to emotion detection and trend detection. We present an evaluation of the framework and a pilot system. Results of confirm the effectiveness of the proposed framework for topic trends and emotion detection of COVID-19 tweets. Our findings revealed Stay-At-Home restrictions result in people expressing on twitter both negative and positive emotional semantics. Semantic trends of safety issues related to staying at home rapidly decreased within the 28 days and also negative feelings related to friends dying and quarantined life increased in some days. These findings have potential to impact public health policy decisions through monitoring trends of emotional feelings of those who are quarantined. The framework presented here has potential to assist in such monitoring by using as an online emotion detection tool kit.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.16.21249943v1" target="_blank">Artificial Intelligence for Emotion-Semantic Trending and People Emotion Detection During COVID-19 Social Isolation</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dexamethasone for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Dexamethasone<br/><b>Sponsor</b>:   University of Oklahoma<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fluvoxamine Administration in Moderate SARS-CoV-2 (COVID-19) Infected Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Placebo;   Drug: Fluvoxamine<br/><b>Sponsor</b>:   SigmaDrugs Research Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>APT™ T3X on the COVID-19 Contamination Rate</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Tetracycline hydrochloride 3%;   Drug: Placebo<br/><b>Sponsors</b>:   University of Nove de Julho;   Santa Casa de Misericórdia de Porto Alegre<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Ivermectin 0.6mg/kg/day;   Drug: Ivermectin 1.0mg/kg/day;   Drug: Placebo;   Drug: Hydroxychloroquine<br/><b>Sponsor</b>:   Corpometria Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: ORTD-1 low dose;   Drug: ORTD-1 mid dose;   Drug: ORTD-1 high dose;   Other: Vehicle control<br/><b>Sponsor</b>:   Oryn Therapeutics, LLC<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process<br/><b>Sponsor</b>:   Hospices Civils de Lyon<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Immunologic Antiviral Therapy With Omalizumab</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Omalizumab;   Other: Placebo<br/><b>Sponsor</b>:   McGill University Health Centre/Research Institute of the McGill University Health Centre<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMUNOR® Preparation in the Prevention of COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: IMUNOR<br/><b>Sponsor</b>:   University Hospital Ostrava<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Doxycycline Tablets;   Drug: Rivaroxaban 15Mg Tab;   Combination Product: Hydroxychloroquine and Azithromycin<br/><b>Sponsor</b>:   Yaounde Central Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Vitamin C 500 MG Oral Tablet;   Drug: Tenofovir disoproxyl fumarate 300 MG Oral Tablet;   Drug: Tenofovir disoproxyl fumarate 300 MG plus emtricitabine 200 MG Oral Tablet<br/><b>Sponsors</b>:   Universidade Federal do Ceara;   Conselho Nacional de Desenvolvimento Científico e Tecnológico;   São José Hospital for Infectious Diseases - HSJ;   Central Laboratory of Public Health of Ceará - Lacen-CE<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase Ⅱb Clinical Trial of Recombinant Corona Virus Disease-19 (COVID-19) Vaccine (Sf9 Cells)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 vaccine (Sf9 cells);   Biological: Placebo<br/><b>Sponsors</b>:   Jiangsu Province Centers for Disease Control and Prevention;   West China Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Safety, Tolerability, and Efficacy of BGE-175 in Participants ≥ 60 Years of Age and Hospitalized With Coronavirus Disease 2019 (COVID-19) That Are Not in Respiratory Failure</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: BGE-175;   Other: Placebo<br/><b>Sponsor</b>:   BioAge Labs, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Betadine© bucal 100 mg/ml;   Drug: Oximen® 3%;   Drug: Clorhexidine Dental PHB©;   Drug: Vitis Xtra Forte©;   Drug: Distilled Water<br/><b>Sponsors</b>:   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   Hospital Universitario Fundación Jiménez Díaz;   Hospital Universitario General de Villalba;   Hospital Universitario Infanta Elena;   Hospital Universitario Virgen de la Arrixaca;   Hospital Clínico Universitario de Valencia;   Dentaid SL<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Drug: Cefditoren pivoxil 400mg<br/><b>Sponsor</b>:   Meiji Pharma Spain S.A.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Early Use of Hyperimmune Plasma in COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: hyperimmune plasma<br/><b>Sponsors</b>:   Catherine Klersy;   Policlinico San Matteo Pavia Fondazione IRCCS<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can limonene be a possible candidate for evaluation as an agent or adjuvant against infection, immunity, and inflammation in COVID-19?</strong> - Coronavirus disease (COVID-19) caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite the tremendous social preventive measures. The therapeutic strategy relies on suppressing infectivity and inflammation, along with immune modulation. The identification of candidate drugs effective for COVID-19 is crucial, thus many natural products...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Docking and Molecular Dynamics Aided Virtual Search of OliveNet Directory for Secoiridoids to Combat SARS-CoV-2 Infection and Associated Hyperinflammatory Responses</strong> - Molecular docking and molecular dynamics aided virtual search of OliveNet™ directory identified potential secoiridoids that combat SARS-CoV-2 entry, replication, and associated hyperinflammatory responses. OliveNet™ is an active directory of phytochemicals obtained from different parts of the olive tree, Olea europaea (Oleaceae). Olive oil, olive fruits containing phenolics, known for their health benefits, are indispensable in the Mediterranean and Arabian diets. Secoiridoids is the largest...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Perspectives: potential therapeutic approach with inhalation of ACE2-derived peptides for SARS-CoV-2 infection</strong> - CONCLUSION: ACE2-derived peptides may play a dual beneficial role in COVID-19, by either preventing virus spread or inhibiting the secretion of pro-inflammatory mediators in airways. Viral, host, and environmental factors may affect the effectiveness of this therapeutic approach to a various extent and represent therefore a matter of investigation for future studies.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunology, immunopathogenesis and immunotherapeutics of COVID-19; an overview</strong> - Coronavirus disease 2019 (COVID-19) infection which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a "public health emergency of international concern" (PHEIC). The infection is highly contagious, has a high mortality rate, and its pathophysiology remains poorly understood. Pulmonary inflammation with substantial lung damage together with generalized immune dysregulation are major components of COVID-19 pathogenesis. The former component, lung damage, seems...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic</strong> - The global spread of COVID-19 constitutes the most dangerous pandemic to emerge during the last one hundred years. About seventy-nine million infections and more than 1.7 million death have been reported to date, along with destruction of the global economy. With the uncertainty evolved by alarming level of genome mutations, coupled with likelihood of generating only a short lived immune response by the vaccine injections, the identification of antiviral drugs for direct therapy is the need of...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2</strong> - The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in December 2019, subsequently its abrupt spread across the world has severely affected human life. In a short span of time, COVID-19 has sacked more than one million human lives and marked as a severe global pandemic, which is drastically accountable for the adverse effect directly to the human society, particularly the health care system...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts</strong> - CONCLUSIONS: As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection. The "Chinese protocol" has already demonstrated clear clinical importance. The use of Chinese herbal medicines that are capable of inhibiting SARS-Cov-2 infection may help to address this immediate unmet clinical need and may be attractive to other countries that are also seeking new options for effective COVID-19 treatment. Our...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dissecting the novel mechanism of Reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification</strong> - CONCLUSION: RDNI can regulate ACE2, Mpro and PLP in COVID-19. The underlying mechanisms of RDNI in the treatment for COVID-19 may be related to the modulation of the cytokine levels and inflammation and its antipyretic activity by regulating the expression of MAPKs, PKC and p65 nuclear factor NF-κB.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacoinformatics approach based identification of potential Nsp15 endoribonuclease modulators for SARS-CoV-2 inhibition</strong> - In the current study, a structure-based virtual screening paradigm was used to screen a small molecular database against the Non-structural protein 15 (Nsp15) endoribonuclease of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 is the causative agent of the recent outbreak of coronavirus disease 2019 (COVID-19) which left the entire world locked down inside the home. A multi-step molecular docking study was performed against antiviral specific compounds (∼8722)...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior</strong> - The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via anti-inflammatory actions exerted by the glucocorticoid receptor (GR). However, technical limitations have restricted our understanding of how GR is involved in the dynamics of NFκB in vivo. In this study, we used an improved lentiviral-based reporter to elucidate the time course of NFκB and...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Feasibility of using alternative swabs and storage solutions for paired SARS-CoV-2 detection and microbiome analysis in the hospital environment</strong> - CONCLUSIONS: Compared to using a clinical-grade synthetic swab, detection of SARS-CoV-2 from environmental samples collected from ICU rooms of patients with COVID was similar using consumer-grade swabs, stored in 95% ethanol. The yield was best from the swab head rather than the eluent and the low level of RNase activity and lack of antibiotics in these samples makes it possible to perform concomitant microbiome analyses. Video abstract.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antibody persistence in the first six months following SARS-CoV-2 infection among hospital workers: a prospective longitudinal study</strong> - CONCLUSION: Neutralizing antibodies persisted at six months in almost all participants, indicating more durability than initially feared. Anti-RBD antibodies persisted better and even increased over time, possibly related to the preferential detection of progressively higher-affinity antibodies.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and targeted treatment of autoimmune and inflammatory diseases</strong> - The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in health, but is released upon necrotic cell death as a bioactive mediator. IL-1α is also expressed by infiltrating myeloid cells within injured tissues. The cytokine binds the IL-1 receptor 1 (IL-1R1), as does IL-1β, and induces the same pro-inflammatory effects. Being a bioactive precursor released upon tissue damage and...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Serum Amyloid P inhibits single stranded RNA-induced lung inflammation, lung damage, and cytokine storm in mice</strong> - SARS-CoV-2 is a single stranded RNA (ssRNA) virus and contains GU-rich sequences distributed abundantly in the genome. In COVID-19, the infection and immune hyperactivation causes accumulation of inflammatory immune cells, blood clots, and protein aggregates in lung fluid, increased lung alveolar wall thickness, and upregulation of serum cytokine levels. A serum protein called serum amyloid P (SAP) has a calming effect on the innate immune system and shows efficacy as a therapeutic for fibrosis...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Host cell glutamine metabolism as a potential antiviral target</strong> - A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in...</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU314054415">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313300659">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid 19 - Chewing Gum</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313269181">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19</strong> - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN313339294">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fahrzeuglüftungssystem und Verfahren zum Betreiben eines solchen Fahrzeuglüftungssystems</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Die Erfindung betrifft ein Fahrzeuglüftungssystem (1) zum Belüften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313868337">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251184">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU313251182">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN312324209">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mund-Nasen-Bedeckung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Mund-Nasen-Bedeckung (1), wobei die Mund-Nasen-Bedeckung (1) mindestens an einem Ohr eines Trägers magnetisch befestigbar ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE313866760">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU311608060">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump May Be Gone, But Trumpism Isn’t</strong> - Even to the disgraceful end of his Presidency, Trump managed to persuade other conservative opportunists that his brand of right-wing populism represents the future of the G.O.P. - <a href="https://www.newyorker.com/news/our-columnists/trump-may-be-gone-but-trumpism-isnt">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can the COVID-19 Vaccine Beat the Proliferation of New Virus Mutations?</strong> - Stopping transmission blocks the opportunity for viral mutation. Vaccination is the only means we have of standing in the virus’s way. - <a href="https://www.newyorker.com/news/daily-comment/can-the-covid-19-vaccine-beat-the-proliferation-of-new-virus-mutations">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Awe and Anguish of Being an American Today</strong> - For all the rousing joy of the political transition, our democracy remains deeply imperilled. - <a href="https://www.newyorker.com/news/our-columnists/the-awe-and-anguish-of-being-an-american-today">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Navalny’s Long-Running Battle with Putin Enters a New Phase</strong> - The jailed opposition leader is creating a model of guerrilla political warfare for the digital age. - <a href="https://www.newyorker.com/news/dispatch/navalnys-long-running-battle-with-putin-enters-a-new-phase">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Takedown of a Dark-Web Marketplace</strong> - One of the world’s largest illicit bazaars was shuttered using data seized from a fortified bunker in Germany. - <a href="https://www.newyorker.com/news/news-desk/the-takedown-of-a-dark-web-marketplace">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>9 questions about budget reconciliation you were too afraid to ask</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/nhhmQwZA0T06_OgTSL7NQSy3y3s=/0x0:4000x3000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68716140/AP_21021722656466.0.jpg"/>
<figcaption>
Senate Majority Leader Chuck Schumer meets with new members of his caucus on January 21. Schumer will have to decide how to use budget reconciliation to pass President Biden’s agenda. | J. Scott Applewhite/AP
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</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Democrats can pass a big bill through the Senate without any Republican votes. Here’s how.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vUmbd8">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pNEqJv">
If <a href="https://www.vox.com/joe-biden">President Joe Biden</a> and <a href="https://www.vox.com/2021/1/6/21534292/senate-2020-results-democrats-win-schumer-biden">Democrats in Congress</a> want to get anything done, they will likely depend on an obscure but powerful procedural tool.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YVuPvW">
This tool is called <a href="https://www.vox.com/policy-and-politics/2016/11/23/13709518/budget-reconciliation-explained">“budget reconciliation,”</a> and it’s something you’re bound to hear a lot about in the coming weeks. This complicated Senate process is the vehicle by which important Democratic priorities could actually pass Congress and reach President Joe Biden’s desk.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q1on8w">
Democrats hold 50 seats Senate. To pass bills, they will have to contend with the Senate’s unusual rules like <a href="https://www.vox.com/21424582/filibuster-joe-biden-2020-senate-democrats-abolish-trump">the filibuster</a>, a procedural requirement that bills receive 60 votes in the Senate to come up for a floor vote. The filibuster would force Democrats to get support from at least 10 Republicans to pass most legislation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pMuR9X">
There is already debate about whether Democrats should just <a href="https://www.vox.com/2019/3/5/18241447/filibuster-reform-explained-warren-booker-sanders">eliminate the filibuster altogether</a> and pass whatever they want with a simple majority. But absent such a big step, they are left with budget reconciliation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RA4Wiv">
They can pass a reconciliation bill with just 50 votes. But reconciliation also comes with certain conditions, limiting what policies can pass through this special process, and that makes legislating a lot more complicated.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W2XJJK">
Here’s what you need to know.
</p>
<h3 id="syqrj5">
<ol style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">What is “budget reconciliation,” and why should I care?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bvsLKy">
In order for a bill to become a law, it needs to pass the United States Senate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3qrRbu">
Democrats control the Senate, the House of Representatives, and the White House, which in theory gives them the power to make laws. But while bills can pass out of the House on a simple majority, almost all bills in the Senate are subject to the “filibuster,” a Senate rule (<a href="https://www.vox.com/videos/2019/6/17/18681798/filibuster-senate-broke-video">but not a law</a>) that requires legislation to receive 60 votes to be brought up for a final vote.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UndAqr">
Almost all bills, but not those passed via the process called budget reconciliation. Under this special procedure, a bill can be brought up for a vote and pass with a simple majority.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IB6n0E">
Democrats’ Senate majority is as thin as can be: 50-50, with Vice President Kamala Harris available to break a tie. For most bills, they’re going to need support from at least 10 Republicans. But using a budget reconciliation bill, they can pass any bill they want, within the limitations that govern the reconciliation process.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ktAZEE">
Biden and senators from both parties are <a href="https://www.vox.com/22231391/joe-biden-inauguration-uniting-america">talking a good game</a> about bipartisanship in the post-Trump, post-storming of the Capitol era. But partisan politics has a way of taking over any legislative debate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dlNJoo">
Democrats may find that in order to pass a Covid-19 relief bill, or other major priorities on taxes, health care, and the environment, they need to muscle through a bill using budget reconciliation. But in exchange for the privilege of passing legislation with “only” 51 votes, budget reconciliation bills are subject to certain rules.
</p>
<h3 id="YVtimV">
<ol start="2" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">What can the Senate pass with budget reconciliation?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gxi6qp">
A lot of things — so long as they affect federal spending and revenue. It’s called <em>budget</em> reconciliation, after all. Reconciliation was established as part of the Congressional Budget Act of 1974, driven by lawmakers concerned about the growing federal deficit.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dIRrjc">
The process begins with a congressional resolution instructing committees in the House and the Senate to draw up legislation. The budget resolution sets the first parameter for what can pass via budget reconciliation: The final bill must reduce or increase the federal deficit by no less or no more than the amount specified in the resolution.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aNp9Jt">
For example: The budget resolution passed by Senate Republicans in 2017 to set up reconciliation for <a href="https://www.vox.com/policy-and-politics/2017/11/14/16634200/republican-tax-reform-byrd-rule">their tax plan</a> stipulated that the bill could increase by the deficit by $1.5 trillion over 10 years — but no more. That became the target as Republicans decided which taxes to cut and which to raise.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S29pLi">
The provisions that are included in the reconciliation bill must then somehow change federal spending or federal revenue. Raising and lowering taxes, expanding subsidies for health insurance, and spending money on new infrastructure projects are some of the obvious, much-discussed ideas that could be included in a reconciliation bill.
</p>
<h3 id="lrbMTt">
<ol start="3" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">What can’t pass with budget reconciliation?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ffR8g9">
Reconciliation was used at first in the 1980s to approve Reagan-era spending cuts, but quickly senators started to use reconciliation for policies unrelated to its original purpose. One reconciliation bill was used to reduce the number of board members on the Federal Communications Commission.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tY9GgJ">
In the eyes of Senate institutionalists like Robert Byrd of West Virginia, these were abuses of the reconciliation process. So Byrd proposed and the Senate codified constraints on what can be passed through budget reconciliation, to make sure the process was actually used for matters affecting the federal budget. Those constraints are now colloquially called <a href="https://www.vox.com/mischiefs-of-faction/2015/10/28/9603518/byrd-rule-planned-parenthood">the Byrd Rule</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9TqbYR">
Under the rule, reconciliation bills can’t change Social Security. They can’t be projected to increase the federal deficit after 10 years. They must affect federal spending or revenue — and their effect on spending or revenue must be “more than incidental” to their policy impact.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LSYswr">
In other words, the primary purpose of the provisions in a reconciliation bill must be to affect the federal deficit; those budgetary effects can’t simply be a byproduct of trying to achieve some other policy aim. To borrow an example that came up a lot during the recent health care debates, changing insurance regulations might not comply with the Byrd Rule. While those changes would surely affect federal spending (the government spends money subsidizing health insurance, so changes to its cost would alter federal outlays), their main policy purpose would be to affect what kind of health coverage people receive.
</p>
<h3 id="ofSxBW">
<ol start="4" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Who decides what can be included in a budget reconciliation bill?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EUJ7aD">
Unelected bureaucrats. Kidding — sort of. There are two important referees in the reconciliation process: the Congressional Budget Office and the Senate parliamentarian.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="szMEjp">
The CBO produces projections on how any legislation, including reconciliation bills, will affect the budget. Ordinarily, those projections have been the guidepost for whether a bill is meeting its reconciliation targets. If CBO says your bill costs $1.5 trillion, and the budget resolution passed to set up reconciliation said the bill was supposed to cost no more than $1 trillion, then you need to cut $500 billion out of the bill.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CJ57qS">
That may not necessarily be an ironclad rule, however: When Senate Republicans were using budget reconciliation to pass the tax bill in 2017, there was <a href="https://www.vox.com/policy-and-politics/2017/11/14/16634200/republican-tax-reform-byrd-rule">speculation</a> they could use their own estimates if the CBO’s were not to their liking. (They ended up not needing to take such a drastic measure, though they still <a href="https://www.nytimes.com/2017/12/04/us/politics/republicans-joint-committee-on-taxation-estimate.html">attacked</a> the Senate’s nonpartisan experts and said the estimates were undervaluing how much their tax bill would spur the economy.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wIiHTn">
And the CBO can be circumvented in other ways. In their 2017 bill, Senate Republicans <a href="https://www.vox.com/policy-and-politics/2017/11/28/16684324/senate-republican-tax-bill-loopholes-inequality">allowed</a> some tax breaks for individuals to expire so that their bill wouldn’t increase the federal deficit outside the 10-year budget window. However, no one at the time actually believed Congress would let those tax cuts sunset — i.e., hike taxes on people — when that deadline comes. It was a gimmick, plain and simple.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Axgm7w">
Aside from CBO, the Senate parliamentarian plays an important role in determining which provisions can be included in a reconciliation bill. The current parliamentarian is Elizabeth MacDonough, who has held that position since 2012 and is the first woman in the job.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UKJJ5S">
There is usually one recurring gray area when making those calls: Is a policy’s budgetary impact “incidental” or not? If it is, under the Byrd Rule, it must be struck from the bill. Traditionally, the parliamentarian makes the final decision after they have heard arguments from both sides about the provisions in question. (It’s called a “Byrd Bath.”)
</p>
<h3 id="g0Unu2">
<ol start="5" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Does the Senate have to listen to the parliamentarian?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3VbjHt">
This is the subject of debate. Traditionally, the parliamentarian’s decision has indeed been final. But that is a norm, not a divine command. Republicans once fired a parliamentarian whose decisions they disagreed with. (The story, in brief: In 2001, Senate Majority Leader Trent Lott was <a href="https://www.latimes.com/archives/la-xpm-2001-may-08-mn-60735-story.html">reportedly annoyed</a> that Parliamentarian Robert Dove blocked Republicans from passing more than one reconciliation bill in a year, and so Lott ousted Dove.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bBIqb3">
Some activists and even some lawmakers have also pointed out that the vice president, who presides over the Senate, has the ultimate authority over what is permissible under budget reconciliation. The parliamentarian technically offers only guidance to the presiding officer. But the vice president hasn’t overruled a parliamentarian since 1975, when Nelson Rockefeller <a href="https://www.senate.gov/about/officers-staff/vice-president/VP_Nelson_Rockefeller.htm">pushed through</a> a change to the Senate filibuster rules against the advice of the parliamentarian.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fO3Wpq">
Some Democratic priorities would seem to be in a Byrd Rule gray area — such as <a href="https://www.rollcall.com/2021/01/22/top-budget-expert-makes-case-for-minimum-wage-in-reconciliation/">a $15 minimum wage</a> and <a href="https://twitter.com/StevenTDennis/status/1101574375847927809">DC statehood</a>, to name two — and Senate Democrats may face pressure to overrule the parliamentarian if she is standing in the way of achieving those goals.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VqSuyC">
But Democrats who are more reluctant to dramatically change Senate procedure might object to that plan. They would argue it sets a precedent that would break the budget reconciliation process forever; any future Senate could simply circumvent the parliamentarian, too, removing the guardrails that are supposed to govern the process.
</p>
<h3 id="yZaYD2">
<ol start="6" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Why can’t the Senate use budget reconciliation for every bill?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pqOLTp">
There is a technical answer and a “real” answer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Cizhv4">
Technically, it’s because a budget reconciliation bill starts with a budget resolution, and Congress passes one budget resolution for any given fiscal year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oLTQ3l">
The budget resolution can, in theory, set up three separate reconciliation bills: one for taxes, one for spending, and one for the federal debt limit. However, in practice, most reconciliation bills have combined taxes and spending into a single piece of legislation. That’s the reason that, historically, the Senate has usually been limited to passing only one budget reconciliation bill in a given fiscal year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TW6SYF">
A side note: Sometimes, they do have wiggle room. In early 2017, Republicans passed one resolution for fiscal year 2017, which was halfway over, and then another for fiscal year 2018, giving them two shots at reconciliation in quick succession. (They used the first bill to try to repeal the ACA and the second for their tax bill.) The Center on Budget and Policy Priorities <a href="https://www.cbpp.org/research/federal-budget/introduction-to-budget-reconciliation">points out</a> Democrats could conceivably pull the same trick this year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T45ia6">
Regardless, the real issue is some senators are <a href="https://slate.com/news-and-politics/2016/11/why-senate-republicans-need-the-filibuster-too.html">very skittish</a> about getting rid of the filibuster — that 60-vote requirement for bringing up most bills for a final vote on the Senate floor — and having reconciliation allows them to avoid it. They can pass <em>some</em> policies with a simple majority without opening the door for any and all bills to be subject to a mere 50-vote threshold.
</p>
<h3 id="hI967t">
<ol start="7" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">This sounds complicated. Wouldn’t it be easier for Democrats to just get rid of the filibuster?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NhXCMN">
The problem is political. Eliminating the filibuster requires 50 votes. Democratic senators from conservative states don’t necessarily want to be asked to take the tough votes again and again. The filibuster gives them protection, by all but mandating that a bill must get at least some bipartisan support before it comes up for a vote.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cABUMO">
Senators who support keeping the filibuster <a href="https://www.nytimes.com/2020/11/30/us/politics/joe-manchin-interview.html">would also say</a> it also helps encourage deliberation and compromise, which are supposed to be the cardinal virtues of the Senate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lHYydi">
In practice, the filibuster has largely served as an obstructionist tool for the minority. That’s why now-Senate Minority Leader Mitch McConnell has been <a href="https://apnews.com/article/joe-biden-mitch-mcconnell-kamala-harris-filibusters-f8b51c0cdded4324f2e78cb74c936c88">insisting</a> on keeping it while negotiating a power-sharing agreement with incoming Senate Majority Leader Chuck Schumer. But Democrats are holding off on making such a promise. Even Democrats from red states, like Jon Tester of Montana, have <a href="https://www.politico.com/news/2021/01/21/democrats-mcconnell-filibuster-460967">said</a> they don’t want to give up the leverage of possibly eliminating the filibuster down the road if Republicans prove unwilling to work with the new majority.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1DOlJv">
Whether Senate Democrats would actually be willing to end the filibuster for legislation is one of the big questions looming over the next two years. The threat to do so could bring Republicans to the negotiating table.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i21lf1">
But whatever they decide on the larger filibuster question, they will get a chance to pass a major bill without any Republican votes, through reconciliation.
</p>
<h3 id="RfM0yU">
<ol start="8" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">What are some previous examples of budget reconciliation bills?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tcTNdM">
President Bill Clinton’s welfare reform bill was passed via reconciliation, as were George W. Bush’s tax cuts. Since 1980, <a href="https://www.cbpp.org/research/federal-budget/introduction-to-budget-reconciliation">21 reconciliation bills</a> have become law, most of them of the tax and spend variety.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YrTL9U">
Reconciliation was critical to the Affordable Care Act’s passage. The House and Senate, both controlled by Democrats in 2009, had passed separate bills for health care reform but not yet come up with a final compromise when Republicans won a special Senate election in Massachusetts to replace the late Ted Kennedy. Democrats lost a 60-vote supermajority, and suddenly it looked impossible to finish health care reform through regular order.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mgZxP9">
To get their plan to President Obama’s desk, House Speaker Nancy Pelosi passed the Senate version of health care reform (the ACA), and Congress then used a reconciliation bill to make some technical changes to the plan, which otherwise would have been made in the conference negotiations between the House and Senate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CFMxev">
After Donald Trump’s election, Republicans tried to repeal and replace Obamacare via reconciliation but couldn’t find 50 votes for their proposals. They did succeed in passing their tax bill through the process in the next fiscal year.
</p>
<h3 id="vBZrFs">
<ol start="9" style="list-style-type: decimal">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Are Democrats going to use reconciliation now? And if so, to do what?
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oslvAr">
We don’t know! Senate Democrats had begun to write a new Covid-19 relief plan that would pass reconciliation muster, but President Biden is urging them to at least try to reach a deal that would win some Republican support.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UnHhDp">
Still, they may end up finding that the GOP isn’t willing to play ball. If Democrats fail to reach a deal with Republicans on Covid-19 relief, it sounds like they will first use reconciliation to pass a pandemic-focused bill.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZwPSE6">
“The objective of both House Democrats and the administration is to get this done as quickly as possible in whatever we need to do,” Rep. John Yarmuth, chair of the House Budget Committee, told reporters. “We haven’t made a decision yet to use reconciliation, but we are prepared to move very quickly if it looks like we can’t do it any other way.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fKxL1T">
Then the question would be whether Democrats try to pass a second reconciliation bill, following the Republican playbook from 2017. <a href="https://www.rollcall.com/2021/01/20/democrats-planning-budget-blitzkrieg-to-pass-biden-agenda/">Other candidates</a> could include a package featuring tax reform and health care provisions. They may try to pass an infrastructure plan through reconciliation if they can’t win any Republican support on that issue.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kULv0o">
This will be among the most important decisions the new Democratic majority makes. Unless they decide they are willing to eliminate the filibuster, budget reconciliation would represent their best chance to achieve some of their big legislative goals.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="j5ssVv">
But they will have to navigate this byzantine set of rules and norms to make it happen.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TunIcP">
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Joe Biden is president, but Rand Paul still won’t admit the election wasn’t stolen</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/ZZsf7_qQuSxDDhr0ezp6pqZwHlQ=/963x0:4238x2456/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68714271/1268595666.0.jpg"/>
<figcaption>
Sen. Rand Paul speaks at the virtual Republican National Convention in August 2020. | Committee on Arrangements for the 2020 Republican National Committee/Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Can’t you just say the words, ‘This election was not stolen?’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BjM3q9">
Four days after the inauguration of Joe Biden as the 46th president of the United States, Sen. Rand Paul found himself unable to admit that the election that sent Biden to the White House was legitimate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QUjVlV">
In a Sunday morning appearance on ABC’s <em>This Week</em>, the Kentucky Republican senator, who has <a href="https://www.kentucky.com/news/politics-government/election/article247010512.html">repeatedly</a> <a href="https://thehill.com/homenews/senate/530492-rand-paul-claims-election-in-many-ways-was-stolen-during-krebs-hearing">affirmed</a> former President Donald Trump’s discredited claims of fraud in the November 3 election, declined to say that that election was not stolen.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S4JQee">
“The debate over ‘whether or not there was fraud’ should occur,” Paul said. “We never had any presentation in court where we actually looked at the evidence. Most of the cases were thrown out for lack of standing, which is a procedural way of not actually hearing the question.”
</p>
<div id="4pQ0ET">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Pressed repeatedly by <a href="https://twitter.com/GStephanopoulos?ref_src=twsrc%5Etfw"><span class="citation">@GStephanopoulos</span></a>, Sen. Rand Paul won’t say the 2020 election wasn’t stolen, calls for investigation of fraud, but doesn’t provide evidence.<br/><br/>GS: “There are not two sides to this story. This has been looked at in every single state.” <a href="https://t.co/P6iz1jjwYE">https://t.co/P6iz1jjwYE</a> <a href="https://t.co/GeWSYe0Bs0">pic.twitter.com/GeWSYe0Bs0</a>
</p>
— This Week (<span class="citation">@ThisWeekABC</span>) <a href="https://twitter.com/ThisWeekABC/status/1353345810327625728?ref_src=twsrc%5Etfw">January 24, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gH8WZ3">
In fact, while some of the Trump campaign’s several dozen lawsuits in battleground states were dismissed or voluntarily withdrawn, many were heard and found to have no merit, a fact that host George Stephanopoulos raised in response.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Heq0rI">
“After investigations, counts and recounts, the Department of Justice, led by William Barr, said there’s no widespread evidence of fraud,” Stephanopoulos said, referring to the former US attorney general, who had been a staunch ally of Trump’s until he publicly stated that there was no evidence of widespread election fraud.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="haOnHg">
<a href="https://www.vox.com/22168109/trump-coup-steal-election-judges-judiciary-supreme-court-gorsuch-kavanaugh-barrett">As Vox’s Ian Millhiser explained</a>, “Trump’s post-election lawsuits failed for a variety of interlocking reasons,” but one of them was simply that “Trump and his allies just didn’t have very good legal arguments”:
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2XzuZD">
In some cases, they <a href="https://www.vox.com/2020/11/5/21550772/trump-lawsuits-vote-counting-pennsylvania-georgia-michigan">brought penny-ante claims</a> that couldn’t have changed the result of the election even if they prevailed. In others, they made factual claims that relied entirely on speculation — or even <a href="https://www.vox.com/21575301/trump-lawsuits-election-rudy-giuliani-pennsylvania-georgia-michigan">relied on conspiracy theories incubated on social media</a>. In some cases, Trump or his allies made legal arguments that were the <a href="https://electionlawblog.org/?p=119196">exact opposite of the arguments they made in other cases</a>. There are no good legal arguments that could have justified tossing out the election results, and the clownishness of Trump’s legal strategy only drew attention to the weakness of his claims.
</p>
</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yG5vXp">
Stephanopoulos kept pressing Paul: “Can’t you just say the words, ‘This election was not stolen?’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DysJ3d">
The senator declined to do so, instead pointing to polling that shows that a majority of Republicans do not trust the election’s outcome.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UUyWYs">
That mistrust is due to a host of factors, not least of which is the baseless assertions, repeated over and over, by lawmakers and other prominent conservatives that fraud took place. Trump himself led this effort, repeating these claims so often that, after a rally dedicated to this theme on January 6, his supporters tried to violently stop the certification of the election results by storming the US Capitol, in an attempted insurrection that ended with five deaths.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TRS3Xc">
Nevertheless, after dozens of court cases, tense “Stop the Steal” rallies, and violence at the seat of the US government, Paul has pledged to spend his remaining two years in office fighting against alleged voter fraud.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HWZFbm">
He said as much on <a href="https://twitter.com/RandPaul/status/1353358887882280960">Twitter</a>, following the TV appearance in which he refused to grant legitimacy to the same election process that has propelled him into power twice.
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Did the New York Times fire an editor over a tweet? The Lauren Wolfe controversy, explained</strong> -
<figure>
<img alt="New York Times logo on a smartphone" src="https://cdn.vox-cdn.com/thumbor/RbzfbP2iFyuOZcmG19LSHCF6Xt8=/0x0:4444x3333/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68714175/1230040807.0.jpg"/>
<figcaption>
Photo illustration by Rafael Henrique/SOPA Images/LightRocket/Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
An editor for the New York Times tweeted that she had “chills” watching Joe Biden’s plane land.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oOEaJe">
On Tuesday, January 19, Lauren Wolfe, an editor working at the New York Times, tweeted that she had “chills” watching President-elect Joe Biden’s plane land outside Washington, DC.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OnKNGq">
Some 36 hours and a concerted campaign against the tweet later, Wolfe was no longer working for the paper of record. Her friends and several other journalists allege that this is because of said tweet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XMvcfH">
Other members of the media have come to Wolfe’s defense, saying that this could open a door for journalists to be targeted with the threat of unemployment based on perceived or overblown offenses.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b2BQLr">
The Times disputes the narrative around Wolfe’s employment, saying in a statement that the paper didn’t “end someone’s employment over a single tweet.”
</p>
<div id="o0gaeW">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
</p><ol style="list-style-type: decimal">
<li>Some news...<br/><br/>Lauren Wolfe, who was an editor on contract for the NYT, has had her contract canceled after she tweeted what's on the left.<br/><br/>Wolfe also tweeted what's on the right, but deleted when she learned Biden chose to take his own plane.<br/><br/>Per two sources. <a href="https://t.co/uaB0INZ1q8">pic.twitter.com/uaB0INZ1q8</a>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
— Yashar Ali (<span class="citation">@yashar</span>) <a href="https://twitter.com/yashar/status/1352471654425743361?ref_src=twsrc%5Etfw">January 22, 2021</a>
</li></ol></blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lIEr3c">
Whatever happened between the paper and Wolfe, the response to her social media post has become the latest flashpoint in an ongoing conversation about how media organizations apply ethical and objectivity standards, and how they should respond to attacks on reporters in a post-Trump era.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uhaU4W">
That question was pertinent during the administration of former President Donald Trump, of course. He regularly sowed mistrust in credible media sources, referring to the press as “the enemy of the people,” and directed vitriol from his supporters at journalists covering his rallies and other events.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U4PMg7">
But even with him out of office, his loyal base remains intent on making known their dissatisfaction with perceived liberal bias in the media, and prominent news organizations are left having to respond to well-orchestrated targeting of the press.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1RH2Mq">
The fallout also points to the lack of labor protections facing many American workers, including those in so-called prestige fields like journalism, and has also led some to point out disparities between what’s alleged about the circumstances of Wolfe’s firing, and how the Times has responded to other reporters in their employ who have been accused of wrongdoing.
</p>
<h3 id="nR4tH9">
The controversy over Lauren Wolfe’s possibly tweet-related firing, explained
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sQlpGY">
Here’s what we know: Wolfe is an <a href="https://laurenmwolfe.com/about/">award-winning</a> journalist and editor whose work has largely focused on women’s rights and <a href="https://cpj.org/reports/2011/06/silencing-crime-sexual-violence-journalists/">sexual violence</a>. She had worked with organizations and outlets like the <a href="https://cpj.org/author/lauren-wolfe-deputy-editor/">Committee to Protect Journalists</a> and <a href="https://foreignpolicy.com/author/lauren-wolfe/">Foreign Policy</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SJ9mtz">
In partnership with the nonprofit Women’s Media Center, she directed Women Under Siege, which documented and mapped instances of sexual violence during conflicts, including the Syrian civil war. A story of hers about war crimes in eastern Congo is <a href="https://www.undispatch.com/journalist-lauren-wolfe-reported-horrendous-war-crime-hours-later-perpetrators-arrested/">credited</a> with leading to the perpetrators’ arrests.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UpipLs">
More recently, she was editing the “Live” section of the Times, primarily working with breaking news, according to the journalist Yashar Ali. However, a Times spokesperson told Vox that Wolfe was not working there full-time, and did not have a contract.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uy9p1j">
On Tuesday afternoon, the day before Biden’s inauguration, Wolfe tweeted out a photo of his airplane landing at Joint Base Andrews outside of Washington, DC. “I have chills,” she wrote. (She’s since deleted the tweet).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4gwnA3">
She also called the administration of former President Donald Trump “childish” for not sending a plane to bring in the new administration. According to Ali, she deleted that post after learning that Biden had chosen to use his own plane.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XvU4rp">
The journalist Glenn Greenwald, a prominent warrior against so-called “cancel culture,” responded by screenshotting and criticizing the sentiment.
</p>
<div id="Ljnhj1">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
If you're in the national press and will be on TV at any point today and being to feel the need to weep joyously, just hold it in until you find a private place. Nobody is expecting any adversarial coverage over the next 4 years, but it's just a matter of personal dignity. <a href="https://t.co/FNKcFRPF56">pic.twitter.com/FNKcFRPF56</a>
</p>
— Glenn Greenwald (<span class="citation">@ggreenwald</span>) <a href="https://twitter.com/ggreenwald/status/1351904097482534912?ref_src=twsrc%5Etfw">January 20, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d2bImA">
Critics began <a href="https://twitter.com/belize042/status/1351648765271302147?s=20">flooding</a> the Twittersphere with criticism of Wolfe and allegations of wider-spread anti-conservative bias among journalists.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1CRvjw">
Ali reported on Thursday, January 21, that according to two unnamed sources, Wolfe had lost her work at the Times<em> </em>following a concerted campaign against both her and the Times<em>. </em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ccDV2D">
In a statement, Times spokesperson Danielle Rhoades Ha disputed that version of events.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gq9J66">
“There’s a lot of inaccurate information circulating on Twitter. For privacy reasons we don’t get into the details of personnel matters but we can say that we didn’t end someone’s employment over a single tweet. Out of respect for the individuals involved we don’t plan to comment further,” Rhoades Ha wrote.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FrCpHg">
She added that Wolfe was not, as Ali had written, on contract, but declined to respond to a follow-up query about the exact nature of Wolfe’s employment at the Times.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="n6rHex">
The online campaign against Wolfe also included severe harassment against Wolfe personally. On Twitter, Wolfe has <a href="https://twitter.com/Wolfe321/status/1352826925836873737">shared examples</a> of some of the online harassment she had received, much of which used obscene, misogynistic, and homophobic language.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GscpH6">
Wolfe did not respond to Vox’s requests for comment. She has not publicly commented on her separation from the Times. Throughout the day on Sunday, she retweeted other journalists’ messages of support, some of which say she was fired over the tweet, before shuttering her account. The account was offline as of Sunday afternoon.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uyHu8Z">
In a lengthy tweet thread, Wolfe’s friend, Josh Shahryar, said that Wolfe has been stalked outside her home and received death threats. Shahryar also said that Wolfe’s sentiment had not been about Biden specifically, but rather about the successful transition of power just two weeks after a mob of Trump supporters had stormed the US Capitol in an attempt to halt the certification of the election.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="589mx0">
But on Twitter, Wolfe also defended the Times, saying that people should not cancel their subscriptions in response to the incident:
</p>
<div id="WEUJJo">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Hi all. I truly appreciate everyone’s support but I need to ask you a favor: PLEASE don’t unsubscribe from <a href="https://twitter.com/nytimes?ref_src=twsrc%5Etfw"><span class="citation">@nytimes</span></a>. I have loved this paper and its mission my whole life. Their journalism is some of the most important &amp; best in the world, &amp; they need to be read widely. Thank you
</p>
— Lauren Wolfe (<span class="citation">@Wolfe321</span>) <a href="https://twitter.com/Wolfe321/status/1353405428638560261?ref_src=twsrc%5Etfw">January 24, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DBA8Tv">
On Twitter, a <a href="https://twitter.com/search?q=%23rehireLauren&amp;src=typeahead_click">#RehireLauren hashtag</a> began trending, as other big names in journalism and elsewhere, including <a href="https://twitter.com/wkamaubell/status/1353232818973773824">W. Kamau Bell</a>, <a href="https://twitter.com/Alyssa_Milano/status/1353210397856157696">Alyssa Milano</a>, and MSNBC’s <a href="https://twitter.com/AliVelshi/status/1353320285315985410">Ali Velshi</a>, came to Wolfe’s defense.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PMtMKT">
Felicia Sonmez, a national political reporter at the Washington Post<em> </em>who’s had her <a href="https://www.theguardian.com/commentisfree/2020/jan/30/felicia-sonmez-affair-was-not-journalism-finest-hour">own brush with her paper’s management over tweets</a>, said that capitulating to online campaigns against reporters would “put ALL journalists at risk.”
</p>
<div id="a1iW4R">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
NYT should not have fired Lauren <a href="https://twitter.com/Wolfe321?ref_src=twsrc%5Etfw"><span class="citation">@Wolfe321</span></a>, especially when other journos at the paper have done far worse recently and kept their jobs.<br/><br/>Knee-jerk firings in response to online harassment campaigns only further embolden harassers — and put ALL journalists at risk. <a href="https://t.co/GB6O1VMMQo">https://t.co/GB6O1VMMQo</a>
</p>
— Felicia Sonmez (<span class="citation">@feliciasonmez</span>) <a href="https://twitter.com/feliciasonmez/status/1353350981677948928?ref_src=twsrc%5Etfw">January 24, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ml7qto">
And Jeremy Scahill, Greenwald’s former colleague at the Intercept, pointed out that other journalists have publicly expressed personal reactions to political moments without incident:
</p>
<div id="dkSIsd">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
I think it’s absurd and wrong that the NYT fired Lauren Wolfe. Also, does anyone remember how MSNBC’s Chris Matthews literally cried over an Obama speech, compared him to Jesus and said he “felt this thrill going up my leg” when Obama spoke? <a href="https://t.co/ZA6iZ6892t">https://t.co/ZA6iZ6892t</a>
</p>
— jeremy scahill (<span class="citation">@jeremyscahill</span>) <a href="https://twitter.com/jeremyscahill/status/1353350959741755397?ref_src=twsrc%5Etfw">January 24, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HdI1rB">
It’s not clear what, exactly, happened between Wolfe and the Times, or why her employment ended. But it’s far from the first time a journalist (particularly a woman) has faced online harassment over a story or a tweet, and far from the last time a news outlet’s handling of it will be subject to scrutiny.
</p>
<h3 id="Tq24cg">
Journalists deserve scrutiny — but scrutiny increasingly means online harassment
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="On4y0j">
This incident has shined a spotlight on a question facing media companies as they transition from a White House that was openly antagonistic toward the press to one with a more traditional relationship with journalists. News outlets are sensitive to accusations that they will not hold the Biden administration as accountable as they did the Trump administration.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2DGmiY">
While Wolfe’s sentiment was relatively benign, some reporters covering Wednesday’s inauguration festivities did <a href="https://www.politico.com/news/magazine/2021/01/21/tone-down-biden-inauguration-media-adulation-461122">fawn over the incoming administration</a>, heralding it as a supposed “<a href="https://www.washingtonpost.com/lifestyle/media/the-media-can-be-glad-for-the-biden-white-houses-return-to-normalcy-but-lets-not-be-lulled/2021/01/20/ea444ac6-5b81-11eb-a976-bad6431e03e2_story.html">return to normalcy</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2q1DJ0">
But targeting a journalist for apparent bias by challenging their employment has become a depressingly successful mob tactic, at a time when reporters face routine threats, both online and <a href="https://www.nytimes.com/2021/01/06/business/media/media-murder-capitol-building.html">in real life</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tw8BRf">
The sociologist Katherine Cross, who studies online harassment, compared this strategy used to target Wolfe with harassment campaigns waged during the <a href="https://www.vox.com/culture/2020/1/20/20808875/gamergate-lessons-cultural-impact-changes-harassment-laws">height of GamerGate</a>:
</p>
<div id="zOItVJ">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Wolfe, who was fired from the NYT for a tweet where she said she had "chills" after Biden landed in DC ahead of the inauguration, is the latest victim of a playbook perfected by the likes of GamerGate and similar harassment campaigns. <a href="https://t.co/cVP3psguiG">https://t.co/cVP3psguiG</a>
</p>
— Katherine Cross (<span class="citation">@Quinnae_Moon</span>) <a href="https://twitter.com/Quinnae_Moon/status/1353189550198149120?ref_src=twsrc%5Etfw">January 24, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ArL6oX">
While we do not know the exact reasoning behind Wolfe’s loss of employment, this episode raises questions about the Times’s personnel decisions, and specifically whether it applies a uniform standard to all of its employees.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3gC6cS">
Just weeks ago, the newspaper weathered a significant crisis after its award-winning podcast, <em>Caliphate</em>, was found to contain substantial inaccuracies. The newspaper <a href="https://www.npr.org/2020/12/18/944594193/new-york-times-retracts-hit-podcast-series-caliphate-on-isis-executioner">retracted the core</a> of that show, and returned a Peabody Award that the show had won.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IQTzqo">
In spite of the fact that the main character of that show was discredited, the journalist behind the project, Rukmini Callimachi, remains at the newspaper, although she was reassigned.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mZSpks">
Her partner on the project, producer Andy Mills, was not publicly disciplined for his part in that scandal. But Mills <a href="https://www.thecut.com/2018/02/at-wnyc-an-uncertain-path-out-of-scandal.html">has been subject</a> to <a href="https://www.washingtonpost.com/opinions/2021/01/08/collapse-caliphate-podcast-brings-scrutiny-nyt-producer-andy-mills/">numerous allegations</a> of <a href="https://twitter.com/jamisonjyork/status/1344117039837945856">mistreating</a> <a href="https://twitter.com/imontheradio/status/1343598441226792960">women</a>, a fact that his former employers at the WNYC program <em>Radiolab</em> have <a href="https://www.wnycstudios.org/podcasts/radiolab/articles/note-radiolab-team">acknowledged</a>, but the Times has not.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3CRaOd">
Elsewhere in the Gray Lady newsroom, the reporter Glenn Thrush was <a href="https://www.nytimes.com/2017/11/20/business/media/glenn-thrush-sexual-misconduct.html">suspended</a> after Vox first <a href="https://www.vox.com/policy-and-politics/2017/11/20/16678094/glenn-thrush-new-york-times">reported allegations of predatory behavior</a> toward young reporters. Although he no longer covers the White House, Thrush <a href="https://www.nytimes.com/by/glenn-thrush">remains</a> employed at the Times.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v0TQO1">
Moreover, while the exact nature of Wolfe’s relationship to the Times<em> </em>is unclear, the termination of it underscores the shaky system of labor protections facing most American workers — even those in prominent or prestigious positions. Shahryar, Wolfe’s friend, said that this loss of income will immediately harm Wolfe and her longtime pet, a rescue dog.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9LFNwD">
Wolfe has the benefit of famous friends and allies, and a story tied to a compelling and emotional public moment. While her friends have so far said they will not fundraise on her behalf, her Venmo account has been made public, and editors at other publications have publicly tweeted her with offers of work.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7AYmwI">
That kind of crowdsourced safety net is not available to most American workers, who also do not have much of a social safety net outside of their employment. And in a country governed by <a href="https://www.vox.com/policy-and-politics/2019/8/21/20826661/bernie-sanders-union-plan-labor-worker-rights-2020">at-will employment laws</a>, and in the midst of a pandemic that has seen tens of millions of Americans out of work, Wolfe’s predicament is taking place across the country — just outside of the public eye.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nicholas Pooran interview: ‘T10 is very exciting’</strong> - The West Indies batsman talks about fast-format cricket and how he looks back at his breathtaking fielding effort in the IPL</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Premier League | Chelsea fires coach Frank Lampard halfway through 2nd season</strong> - Chelsea has lost five of its last eight Premier League games and dropped to ninth place</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The way Root handled himself throughout his knock was a great learning experience: Sangakkara</strong> - After notching up a double century in the series opener, Root continued his brilliant run by hitting 186 in the second Test to lift his side from a spot of bother.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bangladesh vs West Indies 3rd ODI | West Indies chasing 298 in bid to avoid sweep by Bangladesh</strong> - Bangladesh laid a platform for a series sweep against the West Indies after posting 297-6 on January 25 in the third and final one-day cricket intern</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Manchester United compounds Liverpool's woes with victory in FA Cup</strong> - United was joined by Chelsea, Everton, Leicester and Burnley on Sunday in advancing to the round of 16 where it will play West Ham next month.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Special medical team examines M.V. Jayarajan</strong> - CPI(M) Kannur district secretary suffering from COVID-19</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Two held in Manipur for throwing grenade at Raj Bhavan</strong> - Police say the plan was to sabotage official functions on Republic Day.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Farmers’ protest | Punjab CM urges farmers for peaceful R-Day event</strong> - Calls upon Centre to heed the troubled voice of farming community in the true spirit of Indian Republic</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus | India records 131 more COVID-19 deaths, 13,203 cases</strong> - India recorded the lowest number of coronavirus fatalities in over eight months with 131 more deaths being recorded, the Health Ministry said on Janu</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hold elections to Sunni Central Waqf Board, Allahabad HC tells U.P.</strong> - Appoints Minority Welfare Dept. official as administrator for holding polls and forming new body</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: Dutch PM Mark Rutte condemns curfew riots as 'criminal violence'</strong> - Rioters attacked police and set fires to protest against a night-time curfew introduced on Saturday.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid-19: Top adviser warns France at 'emergency' virus moment</strong> - The head of France's scientific council suggests a third lockdown is needed amid spread of variants.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia Navalny protests: Kremlin hits out at West as it downplays rallies</strong> - EU foreign ministers meet to discuss Russia's treatment of Alexei Navalny and his supporters.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Earnings of wealthiest 10 men during pandemic 'could buy vaccines for all'</strong> - Billionaires' wealth has soared while the pandemic has plunged millions into poverty, Oxfam says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mastercard to push up fees for UK purchases from EU</strong> - The move sparks concerns that customers could see prices rise if merchants pass on the higher cost.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Godzilla vs. Kong trailer is a rock ‘em, sock ’em monster mashup</strong> - Directed by Adam Wingard, it's the fourth installment in the "MonsterVerse" franchise - <a href="https://arstechnica.com/?p=1737053">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A curious observer’s guide to quantum mechanics, pt. 3: Rose colored glasses</strong> - “How big is a particle?” Well, that's a subtle (and, unsurprisingly, complex) question. - <a href="https://arstechnica.com/?p=1666644">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Review: Lupin updates classic French gentleman thief for the 21st century</strong> - Omar Sy heads stellar cast in clever series inspired by the works of Maurice Leblanc - <a href="https://arstechnica.com/?p=1735258">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SpaceX launches 143 satellites into orbit, most ever [Updated]</strong> - Party in the payload bay: 143 total satellites deployed in a dozen waves. - <a href="https://arstechnica.com/?p=1736829">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Is this a fossilized lair of the dreaded bobbit worm?</strong> - The giant worms hunted in pretty much the most nightmarish way possible. - <a href="https://arstechnica.com/?p=1736953">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A rude man walks into the bank and tells the teller: "I want to open a fucking checking account." (nsfw)</strong> - <!-- SC_OFF -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The teller, upset, says "We don't tolerate language like that here."
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The man asks "What's the fucking problem? It's not like anyone really gives a shit!"
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The teller then leaves without a word, to go and speak to the manager about how to deal with this man. The manager, hearing the story, goes back to the man to see what the problem is.
</p>
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After asking the man, he responds with " There is no fucking problem. All I wanna do is cash my 10 million dollar check from winning the lottery and then put it in this goddamn bank!"
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The manager responds with "Oh, and is this bitch over here giving you any problems, sir?"
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/AbyssMogul"> /u/AbyssMogul </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l4djsk/a_rude_man_walks_into_the_bank_and_tells_the/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l4djsk/a_rude_man_walks_into_the_bank_and_tells_the/">[comments]</a></span></p></li>
<li><strong>Just caught a disgusting pervert on the bus.</strong> - <!-- SC_OFF -->
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He was watching pornography over my shoulder.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/RayInRed"> /u/RayInRed </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l499lf/just_caught_a_disgusting_pervert_on_the_bus/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l499lf/just_caught_a_disgusting_pervert_on_the_bus/">[comments]</a></span></p></li>
<li><strong>A guy asks his wife, "Honey, why do I always get a boner when I'm looking in the mirror?"</strong> - <!-- SC_OFF -->
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She replies, "because your cock thinks you're a pussy too.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MudakMudakov"> /u/MudakMudakov </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l43rae/a_guy_asks_his_wife_honey_why_do_i_always_get_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l43rae/a_guy_asks_his_wife_honey_why_do_i_always_get_a/">[comments]</a></span></p></li>
<li><strong>A pregnant woman boards a bus. After taking a seat, she notices a man smiling at her. She feels self-conscious and changes her seat, but he seems even more amused. She moves a third time, and he starts to giggle. On her fourth move, he bursts out laughing.</strong> - <!-- SC_OFF -->
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They both get off the bus at the next stop. The pregnant woman is furious and demands an explanation. "What exactly is so damn funny?" "I'm sorry, ma'am," replies the giggling man. "But I couldn't help noticing you're pregnant, and when you first sat down, you sat under an advertisement which read 'Coming Soon: The Gold Dust Twins.' Then you sat under an ad that read 'Sloan's Liniments Remove Swelling.' Then you moved under a deodorant advertisement which read 'William's Stick Did the Trick.' And I just couldn't hold it in any longer when you moved a fourth time and sat under a tire advertisement which read 'Dunlop Rubber Would Have Prevented This Accident.'"
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l3xvyn/a_pregnant_woman_boards_a_bus_after_taking_a_seat/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l3xvyn/a_pregnant_woman_boards_a_bus_after_taking_a_seat/">[comments]</a></span></p></li>
<li><strong>My uncle's joke he just came up with: What are chocolate's preferred pronouns?</strong> - <!-- SC_OFF -->
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Her, She
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Dom_Ross-o"> /u/Dom_Ross-o </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/l4c2nc/my_uncles_joke_he_just_came_up_with_what_are/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/l4c2nc/my_uncles_joke_he_just_came_up_with_what_are/">[comments]</a></span></p></li>
</ul>
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