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+ + + ++Background <br /> The protection of fourth dose mRNA vaccination against SARS-CoV-2 is relevant to current global policy decisions regarding ongoing booster roll-out. We estimate the effect of fourth dose vaccination, prior infection, and duration of PCR positivity in a highly-vaccinated and largely prior-COVID-19 infected cohort of UK healthcare workers. <br /> Methods <br /> Participants underwent fortnightly PCR and regular antibody testing for SARS-CoV-2 and completed symptoms questionnaires. A multi-state model was used to estimate vaccine effectiveness (VE) against infection from a fourth dose compared to a waned third dose, with protection from prior infection and duration of PCR positivity jointly estimated. <br /> Results <br /> 1,298 infections were detected among 9,560 individuals under active follow-up between September 2022 and March 2023. Compared to a waned third dose, fourth dose VE was 13.1% (95%CI 0.9 to 23.8) overall; 24.0% (95%CI 8.5 to 36.8) in the first two months post-vaccination, reducing to 10.3% (95%CI -11.4 to 27.8) and 1.7% (95%CI -17.0 to 17.4) at 2-4 and 4-6 months, respectively. Relative to an infection >2 years ago and controlling for vaccination, 63.6% (95%CI 46.9 to 75.0) and 29.1% (95%CI 3.8 to 43.1) greater protection against infection was estimated for an infection within the past 0-6, and 6-12 months, respectively. A fourth dose was associated with greater protection against asymptomatic infection than symptomatic infection, whilst prior infection independently provided more protection against symptomatic infection, particularly if the infection had occurred within the previous 6 months. Duration of PCR positivity was significantly lower for asymptomatic compared to symptomatic infection. <br /> Conclusions <br /> Despite rapid waning of protection, vaccine boosters remain an important tool in responding to the dynamic COVID-19 landscape; boosting population immunity in advance of periods of anticipated pressure, such as surging infection rates or emerging variants of concern. <br /> Funding <br /> UK Health Security Agency, Medical Research Council, NIHR HPRU Oxford, and others. +
++Researchers and policymakers have proposed systems to detect novel pathogens earlier than existing surveillance systems by monitoring samples from hospital patients, wastewater, and air travel, in order to mitigate future pandemics. How much benefit would such systems offer? We developed, empirically validated, and mathematically characterized a quantitative model that simulates disease spread and detection time for any given disease and detection system. We find that hospital monitoring could have detected COVID-19 in Wuhan 0.4 weeks earlier than it was actually discovered, at 2,300 cases (standard error: 76 cases) compared to 3,400 (standard error: 161 cases). Wastewater monitoring would not have accelerated COVID-19 detection in Wuhan, but provides benefit in smaller catchments and for asymptomatic or long-incubation diseases like polio or HIV/AIDS. Monitoring of air travel provides little benefit in most scenarios we evaluated. In sum, early detection systems can substantially mitigate some future pandemics, but would not have changed the course of COVID-19. +
++The COVID-19 pandemic has highlighted the critical role of genomic surveillance for guiding policy and control strategies. Timeliness is key, but rapid deployment of existing surveillance is difficult because current approaches are based in sequence alignment and phylogeny. Millions of SARS-CoV-2 genomes have been assembled, the largest collection of sequence data in history. Phylogenetic methods are ill equipped to handle this sheer scale. We introduce a pan-genomic measure that examines the information diversity of a k-mer library drawn from a country9s complete set of sequenced genomes. Quantifying diversity is central to ecology. Studies that measure the diversity of various environments increasingly use the concept of Hill numbers, or the effective number of species in a sample, to provide a simple metric for comparing species diversity across environments. The more diverse the sample, the higher the Hill number. We adopt this ecological approach and consider each k-mer an individual and each genome a transect in the pan-genome of the species. Applying Hill numbers in this way allows us to summarize the temporal trajectory of pandemic variants by collapsing each day9s assemblies into genomic equivalents. We do this quickly, without alignment or trees, using modern genome sketching techniques to accommodate millions of genomes in one condensed view of pandemic dynamics. Using data from the UK, USA, and South Africa, we trace the ascendence of new variants of concern as they emerge in local populations. This history of emerging variants uses all available data as it is sequenced, intimating variant sweeps to dominance or declines to extinction at the leading edge of the COVID19 pandemic. The surveillance technique we introduce in a SARS-CoV-2 context here can operate on genomic data generated over any pandemic time course and is organism agnostic. +
++The COVID-19 pandemic has highlighted the need for improved air flow in hospitals, to reduce the transmission of airborne infections such as COVID-19. The aim of this review was to map the existing literature on intervention used to improve air flow in hospitals, understanding challenges in implementation and the findings of any evaluations. We reviewed peer-reviewed articles identified on three databases, MEDLINE, Web of Science and the Cochrane Library with no restriction on date. 5846 articles were identified, 130 were reviewed and 18 were included: ten articles were from databases and eight articles were identified through hand searching. Results were discussed in terms of three categories: (i) concentration of aerosol particles, (ii) changes in/effect of air speed and ventilation and (iii) improvements or reduction in health conditions. Eight studies included an evaluation, the majority only had one comparator condition however three had multiple conditions. The most common device or method that was outlined by researchers was HEPA filters, which can remove particles with a size of 3 microns. Articles outline different interventions to improve air flow and some demonstrate their effectiveness in terms of improving health outcomes for patients, they also suggest either mechanical and natural ventilation are the best methods for dispersing particulate matter as well as perhaps two air cleaning units rather than one. With different methods comes different strengths and weaknesses however, the key finding is that air flow improvement measures reduce the likelihood of nosocomial infections. +
++Protection against SARS-CoV-2 wanes over time, and booster uptake has been low, in part because of concern about side effects. We examined the relationships between local and systemic symptoms, biometric changes, and neutralizing antibodies (nAB) after mRNA vaccination. Data were collected from adults (n = 364) who received two doses of either BNT162b2 or mRNA-1273. Serum nAB concentration was measured at 1 and 6 months post-vaccination. Daily symptom surveys were completed for six days starting on the day of each dose. Concurrently, objective biometric measurements, including skin temperature, heart rate, heart rate variability, and respiratory rate, were collected. We found that certain symptoms (chills, tiredness, feeling unwell, and headache) after the second dose were associated with increases in nAB at 1 and 6 months post-vaccination, to roughly 140-160% the level of individuals without each symptom. Each additional symptom predicted a 1.1-fold nAB increase. Greater increases in skin temperature and heart rate after the second dose predicted higher nAB levels at both time points, but skin temperature change was more predictive of durable (6 month) nAB response than of short-term (1 month) nAB response. In the context of low ongoing vaccine uptake, our convergent symptom and biometric findings suggest that public health messaging could seek to reframe systemic symptoms after vaccination as desirable. +
++Longitudinal research examining childrens mental health (MH) over the course of the COVID-19 pandemic is scarce. We examined trajectories of depression and anxiety over two pandemic years among children with and without MH disorders. Parents and children 2 to 18 years completed surveys at seven timepoints (April 2020 to June 2022). Parents completed validated measures of depression and anxiety for children 8to 18 years, and validated measures of emotional/behavioural symptoms for children 2 to 7 years old. Children 10 years and older completed validated measures of depression and anxiety. Latent growth curve analysis determined depression and anxiety trajectories, accounting for demographics, child and parent MH. Data were available on 1315 unique children (1259 parent-reports, 550 child-reports). Trajectories were stable across the study period, however individual variation in trajectories was statistically significant. Of included covariates, only initial symptom level predicted symptom trajectories. Among participants with pre-COVID data, a significant increase in depression symptoms relative to pre-pandemic levels was observed. Children and adolescents experienced elevated and sustained levels of depression and anxiety during the two-year period. Findings have direct policy implications in the prioritization and of maintenance of educational, recreational, and social activities with added MH supports in the face of future events. +
+Study of the Vector Vaccine GamCovidVac-M (Altered Antigenic Composition) - Conditions: COVID-19
Interventions: Biological: GamCovidVac-M vector vaccine for the prevention of COVID-19 with altered antigenic composition
Sponsors: Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Not yet recruiting
Study of the Vector Vaccine GamCovidVac for the Prevention of COVID-19 With Altered Antigenic Profile With Participation of Adult Volunteers - Conditions: COVID-19
Interventions: Biological: GamCovidVac vector vaccine for the prevention of COVID-19 (with altered antigenic profile)
Sponsors: Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Not yet recruiting
Exercise Interventions in Post-acute Sequelae of Covid-19 - Conditions: COVID-19
Interventions: Behavioral: Exercise
Sponsors: University of Virginia
Not yet recruiting
Effects of Cacao FLAvonoids in LOng Covid Patients (FLALOC) - Conditions: Long Covid19; Fatigue Syndrome, Chronic
Interventions: Dietary Supplement: Flavonoids
Sponsors: Guillermo Ceballos Reyes; Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Recruiting
The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection - Conditions: COVID-19; Vaccine-Preventable Diseases; SARS CoV 2 Infection; Upper Respiratory Tract Infection; Upper Respiratory Disease
Interventions: Biological: Novavax COVID-19 vaccine (2023-2024 formula XBB containing); Biological: Pfizer COVID-19 mRNA vaccine (2023-2024 formula XBB containing)
Sponsors: Sarang K. Yoon, DO, MOH; Westat; Novavax
Not yet recruiting
Motivational Interviewing for Vaccine Uptake in Latinx Adults - Conditions: Vaccine Hesitancy
Interventions: Other: EHR alert; Behavioral: Motivational Interviewing; Behavioral: Warm hand off to nurse
Sponsors: Boston College; East Boston Neighborhood Health Center; Harvard School of Public Health (HSPH); Boston Children’s Hospital; National Institute of Nursing Research (NINR)
Not yet recruiting
Clinical Trial to Evaluate the Safety of RQ-01 in SARS-CoV-2 Positive Subjects - Conditions: COVID-19; Infectious Disease; Symptomatic COVID-19 Infection Laboratory-Confirmed; SARS CoV 2 Infection
Interventions: Combination Product: RQ-001; Other: Placebo
Sponsors: Red Queen Therapeutics, Inc.; PPD
Recruiting
Study of “Sputnik Lite” for the Prevention of COVID-19 With Altered Antigenic Composition. - Conditions: COVID-19
Interventions: Biological: “Sputnik Lite” vaccine for the prevention of COVID-19 with altered antigenic composition
Sponsors: Gamaleya Research Institute of Epidemiology and Microbiology, Health Ministry of the Russian Federation
Not yet recruiting
Study Will Assess the Safety, Neutralizing Activity and Efficacy of AZD3152 in Adults With Conditions Increasing Risk of Inadequate Protective Immune Response After Vaccination and Thus Are at High Risk of Developing Severe COVID-19 - Conditions: COVID-19, SARS-CoV-2
Interventions: Biological: Biological: AZD3152; Biological: Biological: Placebo
Sponsors: AstraZeneca
Not yet recruiting
Examining the Function of Cs4 on Post-COVID-19 Disorders - Conditions: Long COVID
Interventions: Other: Chinese medicine nutritional supplement Cs4
Sponsors: The University of Hong Kong
Recruiting
Amantadine Therapy for Cognitive Impairment in Long COVID - Conditions: Long COVID; Post-COVID19 Condition; Post-Acute COVID19 Syndrome
Interventions: Drug: Amantadine
Sponsors: Ohio State University
Not yet recruiting
Stellate Ganglion Block With Lidocaine for the Treatment of COVID-19-Induced Parosmia - Conditions: Parosmia
Interventions: Procedure: Stellate Ganglion Block; Other: Placebo
Sponsors: Lawson Health Research Institute
Not yet recruiting
CPAP Efficacy in Post-COVID Patients With Sleep Apnea - Conditions: COVID-19; Sleep Apnea
Interventions: Device: Continuous positive airway pressure
Sponsors: University of Pittsburgh
Not yet recruiting
Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Control the Immune Hyperactivation Associated With COVID-19 (THYTECH2) - Conditions: Systemic Inflammatory Response Syndrome
Interventions: Biological: Allogeneic thyTreg 5.000.000; Biological: Allogeneic thyTreg 10.000.000
Sponsors: Hospital General Universitario Gregorio Marañon; Instituto de Salud Carlos III
Recruiting
Angiotensin-(1-7) attenuates SARS-CoV2 spike protein-induced interleukin-6 and interleukin-8 production in alveolar epithelial cells through activation of Mas receptor - BACKGROUND: SARS-CoV-2 spike proteins (SP) can bind to the human angiotensin-converting enzyme 2 (ACE2) in human pulmonary alveolar epithelial cells (HPAEpiC) and trigger an inflammatory process. Angiotensin-(1-7) may have an anti-inflammatory effect through activation of Mas receptor. This study aims to investigate whether SARS-CoV-2 SP can induce inflammation through ACE2 in the alveolar epithelial cells which can be modulated through angiotensin-(1-7)/Mas receptor axis.
Antiviral opportunities of Mannich bases derived from triterpenic N-propargylated indoles - Oleanolic and glycyrrhetic acids alkyne derivatives were synthesized as a result of propargylation of the indole NH-group condensed with the triterpene A-ring, the following aminomethylation led to a series of Mannich bases. The synthesized compounds were tested for their potential inhibition of influenza A/PuertoRico/8/34 (H1N1) virus in Madin-Darby canine kidney (MDCK) cell culture and SARS-CoV-2 pseudovirus in baby hamster kidney-21-human angiotensin-converting enzyme 2 (BHK-21-hACE2) cells….
Alisol B 23-acetate broadly inhibits coronavirus through blocking virus entry and suppresses proinflammatory T cells responses for the treatment of COVID-19 - CONCLUSION: Alisol B 23-acetate could be a promising therapeutic agent for COVID-19 treatment and its underlying mechanisms might be attributed to viral entry inhibition and anti-inflammatory activities.
Universal features of Nsp1-mediated translational shutdown by coronaviruses - Nonstructural protein 1 (Nsp1) produced by coronaviruses inhibits host protein synthesis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Nsp1 C-terminal domain was shown to bind the ribosomal mRNA channel to inhibit translation, but it is unclear whether this mechanism is broadly used by coronaviruses, whether the Nsp1 N-terminal domain binds the ribosome, or how Nsp1 allows viral RNAs to be translated. Here, we investigated Nsp1 from SARS-CoV-2, Middle East respiratory…
Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3 - Coronaviruses (CoVs) are a family of the largest RNA viruses that typically cause respiratory, enteric, and hepatic diseases in animals and humans, imposing great threats to the public safety and animal health. Porcine deltacoronavirus (PDCoV), a newly emerging enteropathogenic coronavirus, causes severe diarrhea in suckling piglets all over the world and poses potential risks of cross-species transmission. Here, we use PDCoV as a model of CoVs to illustrate the reciprocal regulation between…
Porphyrin-derived carbon dots for an enhanced antiviral activity targeting the CTD of SARS-CoV-2 nucleocapsid - CONCLUSIONS: Therefore, this study comprehensively demonstrated the potential of porphyrin-derived carbon dots to be developed further as a promisingly safe and effective COVID-19 antiviral drug.
The Durability of Antibody Responses of Two Doses of High-Dose Relative to Two Doses of Standard-Dose Inactivated Influenza Vaccine in Pediatric Hematopoietic Cell Transplant Recipients: A Multi-Center Randomized Controlled Trial - CONCLUSIONS: Two doses of HD-TIV were more immunogenic than SD-QIV, especially when administered ≥6 months post-HCT. Both groups maintained higher titers compared to baseline throughout the season.
Analysis of SARS-CoV-2 spike RBD binding to ACE2 and its inhibition by fungal cohaerin C using surface enhanced Raman spectroscopy - The structure of the SARS-CoV-2 spike RBD and human ACE2 as well as changes in the structure due to binding activities were analysed using surface enhanced Raman spectroscopy. The inhibitor cohaerin C was applied to inhibit the binding between spike RBD and ACE2. Differences and changes in the Raman spectra were determined using deconvolution of the amide bands and principal component analysis. We thus demonstrate a fast and label-free analysis of the protein structures and the differentiation…
Novel designed analogues of quercetin against SARS-CoV2:an in-silico pharmacokinetic evaluation, molecular modeling, MD simulations based study - Here we present the design of the series of quercetin analogues and their molecular docking study involving the binding of quercetin and its analogues with SARS-CoV2 3CLpro. The scientific literature shows that quercetin compound has been successfully used against SARS-CoV by inhibiting the replication of virus in respiratory epithelial cell through the inhibition of the SARS-CoV main protease (3CLpro.) It was suggested that the modification at position 3 in quercetin structure may produce…
Reply to: Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection - No abstract
SARS-CoV-2 Spike protein peptides displayed in the Pyrococcus furiosus RAD system preserve epitopes antigenicity, immunogenicity, and virus-neutralizing activity of antibodies - Amongst the potential contribution of protein or peptide-display systems to study epitopes with relevant immunological features, the RAD display system stands out as a highly stable scaffold protein that allows the presentation of constrained target peptides. Here, we employed the RAD display system to present peptides derived from the SARS-CoV-2 Spike (S) protein as a tool to detect specific serum antibodies and to generate polyclonal antibodies capable of inhibiting SARS-CoV-2 infectivity in…
Phellinus linteus mycelia extract in COVID-19 prevention and identification of its key metabolic compounds profiling using UPLC-QTOF-MS/MS spectrometry - For centuries, food, herbal medicines, and natural products have been valuable resources for discovering novel antiviral drugs, uncovering new structure-activity relationships, and developing effective strategies to prevent/treat viral infections. One such resource is Phellinus linteus, a mushroom used in folk medicine in Taiwan, Japan, Korea, and China. In this rich historical context, the key metabolites of Phellinus linteus mycelia ethanolic extract (GKPL) impacting the entry of severe acute…
Effect of microfibers induced toxicity in marine sedentary polychaete Hydroides elegans: Insight from embryogenesis axis - Presence of surgical face masks in the environment are more than ever before after the COVID-19 pandemic, and it poses a newer threat to aquatic habitats around the world due to microfibers (MFs) and other contaminants that get discharged when these masks deteriorate. The mechanism behind the developmental toxicity of MFs, especially released from surgical masks, on the early life stages of aquatic organisms are not well understood. Toxicity test were developed to examine the effects of MFs…
COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of pro-inflammatory cytokines/SGLT2 pro-oxidant pathway - CONCLUSIONS: In COVID-19 patients, pro-inflammatory cytokines induced a redox-sensitive up-regulation of SGLT2 expression in ECs, which in turn promoted endothelial injury, senescence, platelet adhesion, aggregation, and thrombin generation. SGLT2 inhibition with empagliflozin, appeared as an attractive strategy to restore vascular homeostasis in COVID-19.
SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway - Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and extra-pulmonary manifestations due to the development of oxidative stress (OS) and hyperinflammation. The underlying cause for OS and hyperinflammation in COVID-19 may be related to the inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidative responses and cellular homeostasis. The Nrf2…
How a New Approach to Public Defense Is Overcoming Mass Incarceration - Public defenders represent eighty per cent of all people charged with a crime in this country, and they typically work in offices that are underfunded and understaffed. - link
McCarthy’s Ouster Is Proof, Once Again, That Appeasement Doesn’t Work - The political-obituary writers will not be kind to one of the weakest House Speakers ever. - link
Trump’s Bloody Campaign Promises - It’s tempting to ignore the former President’s expressions of rage, but the stakes for American democracy demand that attention be paid. - link
Ibram X. Kendi, Hasan Minhaj, and the Question of Selling Out - Is it possible to reap all the rewards of the mass market and still maintain a sense of political purpose? - link
The Border Doesn’t Need Elon Musk’s “Citizen Journalism” - A congressman described Musk as a “concerned citizen with a megaphone.” But Musk’s megaphone is the problem. - link
+Mindfulness without worker power is capitalism at its worst. +
++It has been over a decade since the psychotherapist Miles Neale coined the term “McMindfulness,” which quickly became the buzzword for critiquing a kind of fast food mindfulness training that was marketed as a panacea for stress by everyone from corporations and schools to prisons and governments. +
++The rise of McMindfulness spawned a question that continues to fracture the meditation community: Is spreading meditation always a good thing, whatever its purpose? For Neale, marketing departments and the profit motive geared mindfulness toward its most superficial potential, “like using a rocket launcher to light a candle.” +
++Ronald Purser, a professor of management and an ordained Zen teacher, has gone further, calling McMindfulness “the new capitalist spirituality.” +
++In his account, mainstreaming mindfulness hasn’t just missed the point and given rise to another $300+ million industry. By harnessing mindfulness to mitigate the stress of exploitative corporate practices or steady the aim and focus of military operatives, it has become counter-productive to the original ethical frameworks from which meditation derives. +
++In his 2019 book on the subject, Purser argues that McMindfulness pacifies and fractures the collective discontent that could otherwise be organized to achieve changes in the workplace, like unions, or ultimately, in the economy at large. Instead of fueling the energy for collective struggle and reform, “it just seems like it’s become a lubricant for capitalism,” he noted in an interview with Tricycle: The Buddhist Review. +
++As someone who devotes a fair bit of my life to sitting quietly and doing nothing, I’m on board with the Buddhist idea that there are sources of stress and suffering built into the mind’s habitual ways of operating, and meditation can help unravel them no matter the external conditions. +
++If companies want to help unwind that stress and suffering, I’d prefer a shorter workweek or a raise, rather than a subscription to a mindfulness app like Calm Business. (Though you can see why the latter might appeal to CEOs — one year of the app for a 100-person team costs the company about $5,400 per year, equivalent to just a $54 annual pay bump per employee.) +
++Still, employers offering the apps isn’t in itself a huge deal. My concern is that the rising interest in corporate mindfulness programs will pave the road for businesses to take even more of an active interest in the mental life of their employees. With a new era of neurotechnologies just around the corner that will likely offer unprecedented degrees of surveillance and influence over the mind, it’s worth asking where that road could lead. +
++During the third quarter of the 1984 Super Bowl, Apple — still an insurgent startup, not yet the largest company in the world — aired a commercial depicting an Orwellian society of total conformity. Apple was shown as the hero, the rebel that would free human mind-slaves from the surveillance state. +
++In his 2014 book Psychopolitics, the philosopher Byung-Chul Han points out the irony: Apple “did not signal the end of the surveillance state so much as the inception of a new kind of control society — one whose operations surpass the Orwellian state by leaps and bounds.” +
++The corporate interest in mental health carries an eerie resemblance. At a moment when depression is at record highs, burnout is widespread, and employee engagement hovers around just 30 percent, here comes workplace mindfulness, framed as the hero to free us from our ailments. +
++Already, more than 20 million employees across 3,000+ organizations reportedly use Calm’s business software, complete with a dashboard that provides analytics on employee use of the app and resources designed to encourage uptake. (I can imagine a near future where meditation analytics become resumé candy.) +
++But the nature of a society where corporations take a deep interest in the mental lives of their workers and employ a suite of apps and programs designed to fine-tune consciousness for the better will be shaped by what mental health means to a business. And since the business of business is business, not well-being for well-being’s sake, the corporate vision of mental health is necessarily bound by productivity. +
++This creates a few knots because the drive for productivity can itself be a source of worker distress. Amazon, for example, implemented tiny “ZenBooths” for employees to watch videos about mindfulness, nestled within a company culture that drives employees to skip bathroom breaks for fear of losing their jobs. At its worst, McMindfulness can urge us to look inward for the sources of stress, which can blind us to their true location in the external world. +
++Part of the tension the McMindfulness critique gets at is this: The Buddha urged an understanding of the root causes of stress. For him, that meant the craving and attachment that belief in an illusory, permanent self hitches our minds to. But what about when, to a non-trivial degree, the root cause of stress is work itself? What if the real road to better mental health involves letting productivity fall? Or letting the companies who pay for our mindfulness apps wither away? +
++In early 20th century America, this was almost conventional wisdom. The economist John Maynard Keynes believed that the necessity of labor was at odds with human virtue. As economic growth carried on, we’d progressively free ourselves from work and use our “freedom from pressing economic cares” to learn how we might “live wisely and agreeably and well.” +
++That isn’t what happened. The length of the average workweek has hardly budged for the better part of a century. Even today, as the movement for shorter workweeks is springing back to life, they’re mostly on the table for industries where they won’t harm productivity. A boost in mental health isn’t enough; employers must be convinced that it’s good for business, too. +
++Coming back to the original question of whether it’s always good to have more meditation no matter the means, I think Neale got it basically right: “[T]he more mindfulness practiced by anyone, anywhere, the better off we all are.” But to really practice mindfulness and get to the root causes of stress, we should remember that even in Buddhism, mindfulness was only one part of an eightfold path that covered everything from how one makes a living to nonviolence toward all living beings to avoiding rude language. +
++As neurotechnologies bring consciousness increasingly into the sphere of business interests, it’s crucial that workers have at least two things to go along with their mindfulness subscriptions: representation in corporate governance and safety nets that provide real exit options. +
++Voice and representation — through institutions like unions, sectoral bargaining, or codetermination — will ensure workers have a say in how new neurotechnologies or mental health protocols are integrated into the workplace. That means workers won’t just be subject to the corporate vision of mental health, but they can help shape it. +
++Reweaving the social safety net could mean that anyone, even and especially the lowest-paid, most-precarious workers, can quit a situation that causes them too much stress and go off in search of a job that better aligns with their values. Reforming unemployment insurance, implementing a guaranteed income, or disconnecting health care from employment could all go a long way. But if you look at the anthropologist David Graeber’s survey of Bullshit Jobs, you’ll find that even when the pay is good, the stress of a shitty job can be corrosive to mental health. +
++Calm Business’s landing page reads: “The future of work relies on a mentally healthy workforce.” What if a mentally healthy workforce isn’t a workforce at all and people were simply free to do something other than exchange most of their lifetime for work they don’t particularly enjoy? Maybe the future of mental health relies on freedom from work. +
++A version of this newsletter originally appeared in the Future Perfect newsletter. Sign up here! +
+Could this save democracy from a dangerous threat? Or would it imperil democracy further? +
++Should Donald Trump even be allowed on the ballot in 2024? +
++Some of the country’s most prominent legal experts, and a small number of activists and politicians, argue he shouldn’t — and some have filed lawsuits trying to strike Trump’s name from ballots. +
++Yet most in the Democratic Party are keeping a wary distance from the effort. And other experts argue that such actions, intended to save American democracy, might in fact imperil it even further. +
++The argument for disqualifying Trump hinges on Section 3 of the 14th Amendment to the US Constitution, and its proponents argue that its plain language disqualifies Trump, who they say engaged in “insurrection or rebellion” against the Constitution, from holding office again. +
++Some go so far as to argue that secretaries of state should simply declare Trump ineligible and take him off their ballots — but so far, none have been willing to do so. Instead, then, the hunt is on to find a judge who will do it. +
++To be clear: It seems extremely unlikely that Trump actually will be disqualified, since the Supreme Court will get the final say over any challenge, and they’ll likely nix this whole endeavor. +
++Yet the very existence of the effort raises difficult questions about how a democracy should deal with the threat of a candidate like Trump, who retains a good deal of popular support, but who attempted to steal the 2020 election and talks constantly about having his political opponents imprisoned. +
++A Trump win in 2024 would be deeply dangerous for American democracy. Yet taking away voters’ option to choose him would pose its own perils. It would inevitably be seen as blatant election theft by much of the country — which would trigger responses, both from Republicans in office and Trump supporters on the ground, that could degrade democracy even more severely. +
++The 14th Amendment was ratified in 1868, just after the Civil War, and was meant to deal with its fallout. Some of its provisions were later used as the foundation of modern civil rights law. Section 3 is about a different topic: whether former insurrectionists can hold public office. Its relevant text is as follows: +
++++“No person shall … hold any office, civil or military, under the United States … who, having previously taken an oath … as an officer of the United States … to support the Constitution of the United States, shall have engaged in insurrection or rebellion against the same, or given aid or comfort to the enemies thereof.” +
+
+Days after the January 6, 2021, attack on the US Capitol, some law professors began suggesting that this meant that Trump, and other Republicans whom they viewed as complicit in the insurrection, should be barred from office. +
++Liberal advocacy groups took up the charge in 2022, suing unsuccessfully to try to get Rep. Marjorie Taylor Greene (R-GA) and three Arizona Republican candidates taken off the ballot. Their arguments did prevail in one case, though: A New Mexico judge removed County Commissioner Couy Griffin from his post. (Unlike Greene, Griffin had unlawfully entered the Capitol on January 6 and had been convicted of trespassing.) That marked the first successful use of Section 3 since 1919. +
++This was all warmup to taking on Trump. This August, law professors William Baude and Michael Stokes Paulsen released a 126-page forthcoming law review article on Section 3. They concluded, after a year of studying the topic, that Section 3 sets out a “sweeping” disqualification standard that excludes Trump “and potentially many others” from holding office. +
++The article got enormous attention, in part because Baude and Paulsen are conservatives, and because it was quickly endorsed by liberal law professor Laurence Tribe and conservative former judge J. Michael Luttig, two of the country’s biggest legal names. Steven Calabresi, a founder and co-chair of the board of the Federalist Society, also initially said he was convinced — though he changed his mind a month later. +
++Baude and Paulsen also raised eyebrows for arguing that, per their legal analysis, state election officials should act to take Trump off the ballot now — rather than waiting for Congress or judges to do it. Section 3 is “self-executing,” they argue, so state officials need to obey it. +
++Democratic secretaries of state have not taken the initiative, though, saying this is a matter for the courts. And with a few exceptions — Rep. Jamie Raskin (D-MD) recently opined that Trump is disqualified from running — most Democratic politicians have kept a wary distance from this effort. +
++As much as the party fears and loathes Trump, there is an evident concern that striking him from the ballot would be going too far. Either due to a commitment to democracy, a fear of the explosive backlash that would follow such a move, or a desire to make the effort look less partisan, Democrats like Michigan Secretary of State Jocelyn Benson are saying that it’s out of their hands, try the courts instead. +
++So now the hunt is on to find a judge who will declare Trump ineligible to be president. Citizens for Responsibility and Ethics in Washington (CREW), a longtime progressive advocacy group, has filed suit in Colorado, where a judge has said she hopes to rule on Trump’s eligibility by Thanksgiving. Free Speech for People, another progressive advocacy group, has filed suit in Minnesota. +
++Even before this came lawsuits from Texas tax attorney John Anthony Castro, who is, at least officially, a candidate for the GOP presidential nomination in 2024. Shortly after he registered to run, he filed a lawsuit citing Section 3 to try and get Trump taken off the ballot. He’s since filed similar suits in more than a dozen other states, and constantly hypes up his effort on the website formerly known as Twitter (“They finally realized I’m not fu**ing around. Too late, beta boys,” he wrote recently). The Supreme Court recently declined to take up one of Castro’s appeals, but his other suits are still alive for now. +
++Still, the Supreme Court is the ultimate destination for all of this wrangling, and it has a six-justice conservative majority, three of whom were appointed by Trump. Even before getting into the legal specifics, that’s enough reason to be deeply skeptical that the Court would ban Trump from running again. +
++The legal debates here can be abstruse. They feature attempts to divine the intent of politicians during the 1860s, discussions on how seriously to take an 1869 circuit court opinion by Chief Justice Salmon Chase, and slippery slope hypotheticals about how disqualification could later be abused in different situations. +
++So let’s zoom out and ask the real question at the heart of all this: Would disqualifying Trump from the ballot in this way be a good idea, or would it be its own sort of affront to democracy? +
++Many democracies have struggled with the question of how to deal with a threat to democracy rising through the electoral system, and there are no easy answers. I spoke with Harvard political scientists Steven Levitsky and Daniel Ziblatt, who just co-authored a book, Tyranny of the Minority, on the US’s democratic crisis, about the options. +
++Ziblatt noted Hans Kelsen, an Austrian legal theorist in the 1930s, who he said “made the case that if you really believe in democracy, you have to be willing to go down on a sinking ship and come back another day.” In Kelsen’s view, the only defensible solution to authoritarians rising in the democratic system is to beat them at the ballot box. +
++With the rise of the Nazis, that thinking obviously didn’t age well, said Ziblatt. “I think that’s naive,” he said. “This idea that we need to just stand by and let our democracy come under assault and hope everything will work out — it turned out not to work out.” +
++So the post-World War II German constitution set up a procedure and a legal framework by which certain politicians or parties deemed dangerous to the constitution could be restricted from running for office. “It’s a very complex and highly regulated procedure,” said Ziblatt — involving federal and state offices, a bureaucracy, court approval, and necessary legal steps — because disqualification is such a “potentially dangerous and powerful device.” +
++Other countries have adopted similar approaches, which are known as “militant democracy” or “defensive democracy.” The idea is to protect democracy by excluding the threats to it from the political scene. +
++The thinking is: Trump tried to destroy American democracy in 2020. If he’s allowed to try again, there’s good reason to suspect he’ll do more damage. So why not stop him now? Supporters of disqualifying Trump, like Luttig, argue that he disqualified himself. The Constitution says insurrectionists can’t hold office, and we have a duty to uphold the Constitution, they claim. +
++But the problem with the 14th Amendment option, both Levitsky and Ziblatt told me, is that the US did not establish a consistent procedure or institutional authority for excluding candidates after the Civil War. “We have no agreed-upon institutional mechanism in place, no electoral authority, no judicial body with precedent and practice that all the major political forces agree should be empowered to make this decision,” Levitsky said. +
++Long-standing institutions and procedures provide credibility; ideally, they help assure the nation that these decisions aren’t ad hoc, arbitrary, and politicized — as they are in many countries. In Latin America, Levitsky says, disqualification is often “badly abused” to exclude candidates the powers that be simply don’t want to win. +
++In Trump’s case, what would look to some like dutifully standing up for the Constitution would look to many others like an unprecedented intervention by elites into the electoral process, based on a disputed interpretation of a 155-year-old, rarely used provision — with the clear underlying motivation of preventing voters from making a particular person the president. +
++Both professors blanched at the idea of partisan secretaries of state taking Trump off the ballot on their own. Levitsky called this “deeply problematic,” and Ziblatt said it would be “very fraught and dangerous” and likely to lead to “escalation.” +
++Pro-Trump secretaries of state would surely respond with their own disqualifications of Democratic candidates in reprisal. Indeed, Trump’s supporters already caused chaos at the Capitol when they wrongly believed the election was being stolen from him, and they’re already disenchanted with American institutions. What if Trump truly was prevented from even running by questionable means? Things can always get worse and more dangerous. Legal commentator Mark Herrmann compared secretaries of state disqualifying Trump to opening Pandora’s Box. +
++Given the lack of precedent, the much “healthier path,” Levitsky said, would have been if the Republican Party had managed to self-police by convicting Trump during his second impeachment trial and blocked him from running again. They didn’t — and that’s why we’re in this mess, debating whether democracy can even survive another Trump presidency. +
+The jailed activist’s Nobel is also a reminder of Iran’s momentous protest movement. +
++Narges Mohammadi, an Iranian women’s rights and anti-death penalty advocate currently incarcerated in one of Iran’s most notorious prisons, has been awarded the 2023 Nobel Peace Prize. +
++Mohammadi’s win comes after a year of protest in the country following the murder of Mahsa Amini, a 22-year-old Kurdish Iranian woman who died in police custody after being detained for improperly wearing her headscarf. Though Mohammadi was behind bars during these protests and couldn’t participate directly, she has worked as an advocate for related causes for decades, and continues to document human rights abuses within prison. +
++Mohammadi’s win, though a significant symbolic and political move on the part of the Nobel committee, is unlikely to change Iran’s stance on the protests or its human rights violations. Nor is it likely to free Mohammadi or materially change her condition, though the chair of the Norwegian Nobel Committee Berit Reiss-Andersen said in her speech announcing the prize that she hoped the Iranian authorities would release Mohammadi so she could attend the awards ceremony in December, the Associated Press reported. +
++The award is an explicit recognition of Mohammadi’s decades of work and of the ongoing struggle of women in Iran. +
++“This year’s Peace Prize also recognises the hundreds of thousands of people who, in the preceding year, have demonstrated against the theocratic regime’s policies of discrimination and oppression targeting women,” the committee wrote in a press release Friday. Iranian women who spoke with the Associated Press, like 22-year-old chemistry student Arezou Mohebi, echoed that statement, calling the prize “an award for all Iranian girls and women” and Mohammadi herself “the bravest I have ever seen.” +
++Mohammadi, an engineer by training, has long been an active and important part of the Iranian struggle for human rights, working in particular on behalf of women and incarcerated people and against the death penalty. In 2003, she began working with the now-banned group Defenders of Human Rights Center, founded by Iran’s other Nobel Peace Prize winner, lawyer Shirin Ebadi. +
++Firoozeh Kashani-Sabet, a historian of the modern Middle East at the University of Pennsylvania, told Vox that within Iran, Mohammadi “is very highly respected and admired for her unflinching commitment to freedom, women’s rights, and human rights, as well as for her personal sacrifices in realizing these ideals. People in Iran are rejoicing over this prize.” +
++Mohammadi was first arrested in 2011 for her work advocating for incarcerated human rights activists and their families; while out on bail in 2015, she was again arrested and imprisoned for her campaigning against Iran’s use of the death penalty. In Iran, the death penalty is often used for drug-related offenses or crimes like blasphemy or sowing “corruption on earth” — a charge that can be applied to a variety of activities, such as protesting the government or being LGBTQ. +
++Last year there were around 580 executions in Iran, according to UN Human Rights Chief Volker Türk. Executions have continued apace in 2023; many of those were for drug-related offenses, and many of those executed came from minority populations, according to UN data. “In Iran, authorities use the death penalty and execution as a tool of political repression against protesters, dissidents and minorities” after subjecting the accused to show trials, according to a report this year by a UN body of experts. +
++This is true, too, for the Iranians protesting over the last year. After Amini’s death in September 2022, Iranians of all ages, ethnic groups, and sectors of society engaged in mass demonstrations across the country against the government. Thousands of people flooded the streets night after night — often peacefully, with women whipping off their hijabs and lighting them on fire, or cutting their hair in not just a show of solidarity with Amini, but also an expression of broader economic frustrations and outrage with political repression. +
++This was a woman-led movement — particularly meaningful in a society that specifically restricts women’s access to basic rights like education, jobs, and participation in public life based on whether they comply with compulsory hijab laws, as a June Human Rights Watch report explains. +
++“It’s really touching and kind of unprecedented even, perhaps, globally, this kind of feminist angle, and it is real,” Borzou Daragahi, an Iranian-American journalist, told Vox in November at the height of the protests. “The men supporting the women, the schoolgirls going out and protesting by day, the schoolboys going out and rioting against the police at night, people backing each other up, people cheering on the women as they take off their hijabs and so on. This whole feminist angle of it is quite singular, for a political revolution in any country.” +
++That movement came to be known by its chants of “Woman-Life-Freedom,” and, though Amini’s death ignited it, it built on years — and even decades — of protest and feminist activism by people like Mohammadi. And after years of protest movements, including in 2009 and 2019, Woman-Life-Freedom was one of the most serious challenges to regime power since the 1979 revolution. +
++Iran’s Basij, a paramilitary police force under the Islamic Revolutionary Guard Corps (IRGC), cracked down on the uprising, injuring the eyes of hundreds of protesters with rubber bullets and metal pellets and killing or injuring others when they fired on crowds with lethal force. Ultimately, Iran’s government detained about 20,000 protesters and sentenced many to death. At least 209 people had been executed by May of this year, according to UN reports. +
++Though Mohammadi has been in and out of prison since 2015, she has continued to organize while incarcerated, fighting against inhumane conditions, including allegations of systematic torture and sexual violence. Mohammadi also participated in the Woman-Life-Freedom mass protests in her own way, according to the Norwegian Nobel Committee, expressing her support for activists on the street and organizing solidarity actions among her fellow prisoners. +
++That, however, led to more brutal crackdowns from prison authorities; Mohammadi was barred from receiving phone calls or visitors. She has not seen her husband, Taghi Rahmani, who lives in exile in Paris with their 16-year-old twins, in 11 years. +
++“The global support and recognition of my human rights advocacy makes me more resolved, more responsible, more passionate and more hopeful,” Mohammadi wrote in a statement to the New York Times. “I also hope this recognition makes Iranians protesting for change stronger and more organized. Victory is near.” +
++However, it’s possible that Mohammadi’s win and the international recognition for her work will bring more strife and more crackdowns for her and for Iranian society at large. Regime-linked news agencies dismissed the prize; The Islamic Republic News Agency stated it had become a tool “to satisfy the political desires of the Western countries,” and Fars claimed it honored someone who “persisted in creating tension and unrest and falsely claimed that she was beaten in prison.” +
++Over the past year, the protests have garnered less media attention, and the regime has cracked down on society by purging academics from universities and arresting activists and journalists. Although the protests did not topple the government, it does seem to have caused an enduring fracture between the regime and society. That’s partly a result of the multiple crises — economic, political, and social — that Iran is currently facing, but it also speaks to the strength of the protest movement. +
++Now, Kashani-Sabet said, “Mohammadi’s Nobel Prize will keep the embers of the Woman, Life, Freedom movement burning and alert the world that Iranian women and the Iranian people have not abandoned their resolve to usher in a free and tolerant Iran.” +
The way I shot right through the Asian Games was really pleasing: Jyothi - HYDERABAD
Hangzhou Asian Games | Indian men and women’s chess teams clinch silver medals - While China won the gold in the women’s event, Iran emerged champions in the men’s event.
Hangzhou Asian Games | Deepak Punia settles for silver, Indian wrestlers return with six medals - Sunil Kumar (87kg), Antim Panghal (53kg), Sonam Malik (62kg), Aman Sehrawat (57kg) and Kiran Bishnoi (76kg) were the other medal winners for India.
Hangzhou Asian Games hockey | Indian women beat defending champion Japan; clinch bronze - The Indians, ranked seventh in the world, were the favourites to win the gold but one bad match cost them dearly as hosts China thrashed them 4-0 in the semifinal
India vs Australia WC | Confident India ready for Australian challenge - At Chepauk, India have won seven out of 14 ODIs with six defeats and one game abandoned. Australia have in fact won five out of their six ODIs at this venue.
Animal keeper killed by elephant in Hyderabad zoo - Mohd. Shahabaz entered the enclosure of the male elephant when the pachyderm hit him to a wall
Vintage car rally taken out in Ooty -
Kerala bishop under fire as critics call religious court he formed to try priest reminiscent of ‘Inquisition’ - Mar Remigiose Inchananiyil, Bishop of Thamarassery diocese, issued an order constituting the religious court on September 21, 2023 against Fr. Thomas, aka Aji, Puthiyaparambil
Sikkim flash floods: Eight soldiers killed; search on for 14 missing - Eight Army soldiers were among those killed in the flash flood which was triggered by a glacial lake burst in Sikkim
Firecracker godown gutted at Attibele-Hosur border - Nine fire tenders were pressed into service, which are now struggling to put out the fire.
Bavaria election: Toxic campaign heralds big vote for Germany’s populists - Right-wing parties look set to make big gains in state elections in Germany’s wealthy south.
Ukraine dam: Rebuilding shattered lives after Ukraine’s dam collapse - Despite water shortages, losing loved ones, homes and crops, people affected by the collapse of Ukraine’s Kakhovka dam are determined to rebuild.
Juan Carlos: Court throws out ex-lover’s €145m legal case - A court in London has thrown out a legal case brought by a former lover of the ex-king of Spain.
Ukraine war: Every family in Hroza village affected by missile attack - At least 52 people, including a child, were killed in Thursday’s Russian missile strike, Ukraine says.
Ukraine cyber-conflict: Hacking gangs vow to de-escalate - Ukrainian and Russian hacktivists tell the BBC they will comply with newly-created cyber-war rules.
Vaccine may save endangered California condors from succumbing to bird flu - Avian flu vaccines are being used on birds for the first time in the US. - link
Thousands of Android devices come with unkillable backdoor preinstalled - Somehow, advanced Triada malware was added to devices before reaching resellers. - link
US government considers protecting octopuses used in research - Prior to the pending rules, no invertebrates were subject to regulation. - link
23andMe says private user data is up for sale after being scraped - Records reportedly belong to millions of users who opted in to a relative-search feature. - link
“Real Water” that poisoned dozens contained chemical from rocket fuel - An expert witness testified hydrazine was likely formed during an electrolysis process. - link
A woman buys a wardrobe for her bedroom -
++After it is installed all is well until the train passes on the nearby track and the wardrobe falls down. +
++She calls a technician to check it out, he proceeds to secure it with some supports but when the train passes it again falls down. +
++Surprised but determined, the technician again installs more supports and enters the wardrobe to feel what’s causing it to fall. +
++At that time the jealous husband enters the home early and starts searching the house for signs of another man. +
++He opens the wardrobe, sees the technician and asks “what are you doing here?” +
++The technician replies: “would you believe me if I told you I’m waiting for the train?” +
+ submitted by /u/RedLineGR
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A Gynaecologist had become fed up with malpractice insurance and paperwork and was burned out. -
++Hoping to try another career where skilful hands would be beneficial, he decided to become a mechanic. He went to the local technical college, signed up for evening classes, attended diligently, and learned all he could. +
++When the time of the practical exam approached, the gynaecologist prepared carefully for weeks and completed the exam with tremendous skill. When the results came back, he was surprised to find that he had obtained a score of 150%. Fearing an error, he called the Instructor, saying, “I don’t want to appear ungrateful for such an outstanding result, but I wonder if there is an error in the grade?” +
++“The instructor said,”During the exam, you took the engine apart perfectly, which was worth 50% of the total mark. You put the engine back together again perfectly, which is also worth 50% of the mark." +
++After a pause, the instructor added, “I gave you an extra 50% because you did it all through the exhaust, which I’ve never seen done in my entire career”. +
+ submitted by /u/orgasmic2021
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What’s the difference between a dollar and a pound? -
++I don’t dollar your mom. +
+ submitted by /u/albyagolfer
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A doctor gets called to the hospital in the middle of the night -
++As it’s an emergency, and the highway is completely empty at this time of night, he’s going a little over the speed limit. Suddenly, he sees blue lights fire up behind him, and he’s pulled over. +
++The cop approaches the car and says “Do you know how fast you were going?” +
++“About five miles an hour over,” says the doctor. “Sorry. I’m a doctor, and one of my patients has taken a turn for the worse, so I’m rushing to the hospital.” +
++“The rules are the rules,” replies the cop. “I’ve gotta give you a ticket.” The cop starts writing it out and, as he does, asks “What kind of doctor are you, anyway?” +
++“I’m an asshole stretcher,” says the doctor. “One of the best, actually.” +
++“You’re a what?” says the baffled cop, looking up from the ticket. +
++“Yeah, if they need an asshole stretching they come to me. I can easily get them two, three feet wide. Some I’ve got up to six foot.” +
++“What the hell do you do with a six-foot asshole?” asks the incredulous cop. +
++“You get him to stop people going five miles an hour over the limit at 3am.” +
++ +
+ submitted by /u/obamasmole
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You guys ever have this happen to you? -
++You guys ever have this happen to you? +
++I was out at the bar the other night. They had a good band laying down all sorts of songs. +
++When they played the Twist, I did the twist. +
++When they played Jump, I jumped. +
++But when they played Come On, Eileen, I got kicked outta the place! +
+ submitted by /u/DevonSun
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