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<title>17 September, 2023</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Deep learning predictions of TCR-epitope interactions reveal epitope-specific chains in dual alpha T cells</strong> -
<div>
T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T-cell activation is elicited by the binding of the T-cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specificity is determined by the sequence of its and {beta} chains. Here, we collected and curated a dataset of 17,715 alpha beta TCRs interacting with dozens of class I and class II epitopes. We used this curated data to develop MixTCRpred, a deep learning TCR-epitope interaction predictor. MixTCRpred accurately predicts TCRs recognizing several viral and cancer epitopes. MixTCRpred further provides a useful quality control tool for multiplexed single-cell TCR sequencing assays of epitope-specific T cells and pinpoints a substantial fraction of putative contaminants in public databases. Analysis of epitope-specific dual alpha T cells demonstrates that MixTCRpred can identify alpha chains mediating epitope recognition. Applying MixTCRpred to TCR repertoires from COVID-19 patients reveals enrichment of clonotypes predicted to bind an immunodominant SARS-CoV-2 epitope. Overall, MixTCRpred provides a robust tool to predict TCRs interacting with specific epitopes and interpret TCR-sequencing data from both bulk and epitope-specific T cells.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.13.557561v1" target="_blank">Deep learning predictions of TCR-epitope interactions reveal epitope-specific chains in dual alpha T cells</a>
</div></li>
<li><strong>Refining COVID-19 retrospective diagnosis with continuous serological tests: a Bayesian mixture model</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
COVID-19 serological tests with a “positive”, “intermediate” or “negative” result according to predefined thresholds cannot be directly interpreted as a probability of having been infected with SARS-CoV-2. Based on 81,797 continuous anti-spike tests collected in France after the first wave, a Bayesian mixture model was developed to provide a tailored infection probability for each participant. Depending on the serological value and the context (age and administrative region), a negative or a positive test could correspond to a probability of infection as high as 61.9% or as low as 68.0%, respectively. In infected individuals, the model estimated a proportion of “non-responders” of 14.5% (95% CI, 11.2-18.1%), corresponding to a sub-group of persons who exhibited a weaker serological response to SARS-CoV-2. This model allows for an individual interpretation of serological results as a probability of infection, depending on the context and without any notion of threshold.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.09.15.23295603v1" target="_blank">Refining COVID-19 retrospective diagnosis with continuous serological tests: a Bayesian mixture model</a>
</div></li>
<li><strong>MixOmics Integration of Biological Datasets Identifies Highly Correlated Key Variables of COVID-19 severity.</strong> -
<div>
Background: Despite several years since the COVID-19 pandemic was declared, challenges remain in understanding the factors that can predict the severity of COVID-19 disease and complications of SARS-CoV-2 infection. While many large-scale Multiomic datasets have been published, integration of these datasets has the potential to substantially increase the biological insight gained allowing a more complex comprehension of the disease pathogenesis. Such insight may improve our ability to predict disease progression, detect severe cases more rapidly and develop effective therapeutics. Methods: In this study we have applied an innovative machine learning algorithm to delineate COVID-severity based on integration of paired samples of proteomic and transcriptomic data from a small cohort of patients testing positive for SARS-CoV-2 infection with differential disease severity. Targeted plasma proteomics and an onco-immune targeted transcriptomic panel was performed on sequential samples from a cohort of 23 severe, 21 moderate and 10 mild COVID-19 patients. We applied DIABLO, a new integrative method, to identify multi-omics biomarker panels that can discriminate between multiple phenotypic groups, such as the varied severity of disease in COVID-19 patients. Results: As COVID-19 severity is known among our sample group, we can train models using this as the outcome variable and calculate features that are important predictors of severe disease. In this study, we detect highly correlated key variables of severe COVID-19 using transcriptomic discriminant analysis and multi-omics integration methods. Conclusions: This approach highlights the power of data integration from a small cohort of patients offering a better biological understanding of the molecular mechanisms driving COVID-19 severity and an opportunity to improve prediction of disease trajectories and targeted therapeutics.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.14.557558v1" target="_blank">MixOmics Integration of Biological Datasets Identifies Highly Correlated Key Variables of COVID-19 severity.</a>
</div></li>
<li><strong>Cooperativity and induced oligomerisation control the interaction of SARS- CoV-2 with its cellular receptor and patient-derived antibodies</strong> -
<div>
Viral entry is mediated by oligomeric proteins on the virus and cell surfaces. The association is therefore open to multivalent interactions between these proteins, yet such recognition is typically rationalised as affinity between monomeric equivalents. As a result, assessment of the thermodynamic mechanisms that control viral entry has been limited. Here, we use mass photometry to overcome the analytical challenges consequent to multivalency. Examining the interaction between the spike protein of SARS-CoV-2 and the ACE2 receptor, we find that ACE2 induces oligomerisation of spike in a variant- dependent fashion. We also demonstrate that patient-derived antibodies use induced-oligomerisation as a primary inhibition mechanism or to enhance the effects of receptor-site blocking. Our results reveal that naive affinity measurements are poor predictors of potency, and introduce a novel antibody-based inhibition mechanism for oligomeric targets.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.14.557399v1" target="_blank">Cooperativity and induced oligomerisation control the interaction of SARS- CoV-2 with its cellular receptor and patient-derived antibodies</a>
</div></li>
<li><strong>The SARS-CoV-2 nucleoprotein associates with anionic lipid membranes</strong> -
<div>
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a lipid-enveloped virus that acquires its lipid bilayer from the host cell it infects. SARS-CoV-2 can spread from cell to cell or from patient to patient by undergoing assembly and budding to form new virions. The assembly and budding of SARS-CoV-2 is mediated by several structural proteins known as envelope (E), membrane (M), nucleoprotein (N) and spike (S), which can form virus-like particles (VLPs) when co-expressed in mammalian cells. Assembly and budding of SARS-CoV-2 from the host ER-Golgi intermediate compartment is a critical step in the virus acquiring its lipid bilayer. To date, little information is available on how SARS-CoV-2 assembles and forms new viral particles from host membranes. In this study, we find the N protein can strongly associate with anionic lipids including phosphoinositides and phosphatidylserine. Moreover, lipid binding is shown to occur in the N protein C-terminal domain, which is supported by extensive in silico analysis. Anionic lipid binding occurs for both the free and N oligomeric forms suggesting N can associate with membranes in the nucleocapsid form. Herein we present a lipid-dependent model based on in vitro, cellular and in silico data for the recruitment of N to M assembly sites in the lifecycle of SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.15.557899v1" target="_blank">The SARS-CoV-2 nucleoprotein associates with anionic lipid membranes</a>
</div></li>
<li><strong>Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster</strong> -
<div>
As the SARS-CoV-2 virus continues to evolve, novel XBB sub-lineages such as XBB.1.5, XBB.1.16, EG.5, HK.3 (FLip), and XBB.2.3, as well as the most recent BA.2.86, have been identified and aroused global concern. Understanding the efficacy of current vaccines and the immune system's response to these emerging variants is critical for global public health. In this study, we evaluated the neutralization activities of sera from participants who received COVID-19 inactivated vaccines, or a booster vaccination of the recently approved tetravalent protein vaccine in China (SCTV01E), or had contracted a breakthrough infection with BA.5/BF.7/XBB virus. Comparative analysis of their neutralization profiles against a broad panel of 30 SARS-CoV-2 sub-lineage viruses revealed that strains such as BQ.1.1, CH.1.1, and all the XBB sub-lineages exhibited heightened resistance to neutralization than previous variants, however, despite the extra mutations carried by emerging XBB sub-lineages and BA.2.86, they did not demonstrate significantly increased resistance to neutralization compared to XBB.1.5. Encouragingly, the SCTV01E booster vaccination consistently induced robust and considerably higher neutralizing titers against all these variants than breakthrough infection did. Cellular immunity assays also showed that the SCTV01E booster vaccination elicited a higher frequency of virus-specific memory B cells but not IFN-{gamma} secreting T cells. Our findings underline the importance of developing novel multivalent vaccines to more effectively combat future viral variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.14.557682v1" target="_blank">Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster</a>
</div></li>
<li><strong>Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics</strong> -
<div>
We integrate evolutionary predictions based on the neutral theory of molecular evolution with protein dynamics to generate mechanistic insight into the molecular adaptations of the SARS-COV-2 Spike (S) protein. With this approach, we first identified Candidate Adaptive Polymorphisms (CAPs) of the SARS-CoV-2 Spike protein and assessed the impact of these CAPs through dynamics analysis. Not only have we found that CAPs frequently overlap with well-known functional sites, but also, using several different dynamics-based metrics, we reveal the critical allosteric interplay between SARS-CoV-2 CAPs and the S protein binding sites with the human ACE2 (hACE2) protein. CAPs interact far differently with the hACE2 binding site residues in the open conformation of S protein compared to the closed form. In particular, the CAP sites control the dynamics binding residues in the open state, suggesting an allosteric control of hACE2 binding. We also explored the characteristic mutations of different SARS-CoV-2 strains to find dynamic hallmarks and potential effects of future mutations. Our analyses reveal that Delta strain-specific variants have non-additive (i.e., epistatic) interactions with CAP sites, whereas the less pathogenic Omicron strains have mostly compensatory variants. Finally, our dynamics-based analysis suggests that the novel mutations observed in the Omicron strain epistatically interact with the CAP sites to help escape antibody binding.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.14.557827v1" target="_blank">Some mechanistic underpinnings of molecular adaptations of SARS-COV-2 spike protein by integrating candidate adaptive polymorphisms with protein dynamics</a>
</div></li>
<li><strong>Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Abstract: Background Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that alox genes, involved in eicosanoid synthesis, were up-regulated in high WHO score patients, especially in goblet cells. Herein, we aimed to further understand the roles played by eicosanoids during severe SARS-CoV-2 infection. Methods and findings We performed a total fatty acid panel on plasma and bulk RNA-seq analysis on peripheral blood mononuclear cells (PBMCs) collected from 10 infected and 10 uninfected patients. Univariate comparison of lipid metabolites revealed that lipid metabolites were increased in SARS-CoV-2 patients including the lipid mediators Arachidonic Acid (AA) and Eicosapentaenoic Acid (EPA). AA, EPA and the fatty acids Docosahexaenoic acid (DHA) and Docosapentaenoic acid (DPA), were positively correlated to WHO disease severity score. Transcriptomic analysis demonstrated that COVID-19 patients can be segregated based on WHO scores. Ontology, KEGG and Reactome analysis identified pathways enriched for genes related to innate immunity, interactions between lymphoid and nonlymphoid cells, interleukin signaling and, cell cycling pathways. Conclusions Our study offers an association between nasopharynx mucosa eicosanoid genes expression, specific serum inflammatory lipids and, subsequent DNA damage pathways activation in PBMCs to severity of COVID-19 infection.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.09.14.23295549v1" target="_blank">Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection</a>
</div></li>
<li><strong>Diagnostic testing and the evolution of detection avoidance by pathogens</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Diagnostic testing is a key tool in the fight against many infectious diseases. The emergence of pathogen variants that are able to avoid detection by diagnostic testing therefore represents a key challenge for public health. In recent years, variants for multiple pathogens have emerged which escape diagnostic testing, including mutations in Plasmodium falciparum (malaria), Chlamydia trachomatis (chlamydia) and SARS-CoV-2 (COVID-19). However, little is currently known about when and the extent to which diagnostic test escape will evolve. Here we use a mathematical model to explore how the frequency of diagnostic testing, combined with variation in compliance and efficacy of quarantining, together drive the evolution of detection avoidance. We derive key thresholds under which a testing regime will (i) select for diagnostic test avoidance, or (ii) drive the pathogen extinct. Crucially, we show that imperfect compliance with diagnostic testing regimes can have marked effects on selection for detection avoidance, and consequently, for disease control. Yet somewhat counterintuitively, we find that an intermediate level of testing can select for the highest level of detection avoidance. Our results, combined with evidence from various pathogens, demonstrate that the evolution of diagnostic testing avoidance should be carefully considered when designing diagnostic testing regimes.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.09.14.23295480v1" target="_blank">Diagnostic testing and the evolution of detection avoidance by pathogens</a>
</div></li>
<li><strong>Assessing the impact of the Gamma variant on COVID-19 Patient admissions in a Southern Brazilian tertiary hospital - A comparison of dual pandemic phases</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Since the first case of COVID-19, Brazil has undergone infection waves with distinct characteristics. The description of new variants has alerted the emergence of more contagious or virulent viruses. The variant of concern Gamma emerged in Brazil and caused an epidemic wave, but its spread outside the country was limited. We report the clinical epidemiological profile of hospitalized patients with COVID-19 by comparing two periods. A retrospective cohort study was performed. The primary outcome was to assess individuals with COVID-19 admitted in wards and intensive care units at CHC-UFPR between March 2020 and July 2021, correlating demographic, clinical-epidemiologic, and survival data with the most prevalent viral variant found in each period. We used Kaplan?Meier analysis to estimate the probability of survival and receiver operating characteristic curves to evaluate laboratory tests to find a cutoff point for poor outcomes. Data from 2,887 individuals were analyzed, 1,495 and 1,392 from the first and second periods, respectively. Hospitalization predominated among males in both periods, and the median age was significantly lower in the second one. The frequency of comorbidities was similar. Various demographic factors, clinical assessments, and laboratory tests were examined in relation to greater severity. When comparing the two studied periods, we observed predominance of the Wild virus during the first wave and the Gamma variant during the second, with no significant difference in outcomes. The findings suggest that despite the association of many factors with increased severity, the temporal variation between the two periods did not result in a notable divergence in the measured outcomes. The COVID-19 pandemic has lasted for a long time, with periods marked by peaks of cases, often caused by the emergence of viral variants, resulting in higher infection rates and rapid dissemination but, for variant Gamma, no apparent greater virulence.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.09.13.23295114v1" target="_blank">Assessing the impact of the Gamma variant on COVID-19 Patient admissions in a Southern Brazilian tertiary hospital - A comparison of dual pandemic phases</a>
</div></li>
<li><strong>Associations with LGBTQ+ mental health disparities during the COVID-19 pandemic</strong> -
<div>
The COVID-19 pandemic has created tremendous, and unequal, burdens on mental and physical health throughout the United States. Prior work suggests that LGBTQ+ individuals have experienced disproportionate harms during the COVID-19 pandemic, but potential mechanisms underlying these disparities remain unclear. In a large (N=893) sample of US LGBTQ+ adults, we examined four theoretically derived risk factors as potential contributors to depression, anxiety, and suicidal ideation during the summer of 2020. Stressors and disruptions due to the COVID-19 pandemic were common, with over 25% of participants experiencing changes in their living situation, 40% reporting interruptions in health care access, and high levels of stress due to social isolation, financial concerns, and increased mental health symptoms. We found that social disconnection, disruptions in health care, financial strain, and efforts to avoid disclosing one’s sexual orientation or gender identity at home were each associated with poorer mental health, with the largest effects evident for identity disclosure avoidance. Transgender and non-binary adults reported poorer mental health overall, but gender identity did not moderate the effects of other tested risk factors. Results highlight the importance of considering LGBTQ+ mental health in the context of minority stressors, in addition to more general social determinants of health.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/3famu/" target="_blank">Associations with LGBTQ+ mental health disparities during the COVID-19 pandemic</a>
</div></li>
<li><strong>Outbreak of severe community-acquired bacterial infections from Streptococcus pyogenes, Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae among children in North Rhine-Westphalia (Germany), October to December 2022</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: In late 2022, a surge of severe bacterial infections caused by S. pyogenes was reported in several European countries, including Germany. This study assessed disease burden and severity of hospitalizations for community-acquired bacterial infections with S. pyogenes, S. pneumoniae, N. meningitidis, and H. influenzae among children in North Rhine-Westphalia (NRW), Germany, during the last quarter of 2022 compared to long-term incidences. Methods: Hospital cases due to bacterial infections between October and December 2022 were collected from 59/62 (95 %) children9s hospitals in NRW and combined with surveillance data (2016 - 2023) from the national reference laboratories for streptococci, N. meningitidis, and H. influenzae. Total cases in NRW and incidence rates from January 2016 to March 2023 were estimated by capture-recapture analyses. Expected annual deaths from the studied pathogens were calculated from national death cause statistics. Results: Between October and December 2022, 153 cases with high overall disease severity were reported with pneumonia being most common (59 %, n = 91). Incidence rates of bacterial infections declined at the beginning of the COVID-19 pandemic. In late 2022 and early 2023 a massive surge to levels unprecedented since 2016 was observed, mainly driven by S. pyogenes and S. pneumoniae. Observed deaths during the study period exceeded the expected number for the entire year in NRW by far (7 vs. 0.9). Discussion: The unprecedented peak of bacterial infections in late 2022 and early 2023 was caused by various mechanisms intertwined that require close surveillance and improved precautionary measures for future outbreaks.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.09.14.23295531v1" target="_blank">Outbreak of severe community-acquired bacterial infections from Streptococcus pyogenes, Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae among children in North Rhine-Westphalia (Germany), October to December 2022</a>
</div></li>
<li><strong>Regulation of interferon signaling by transposon exonization</strong> -
<div>
Innate immune signaling is essential for clearing pathogens and damaged cells, and must be tightly regulated to avoid excessive inflammation or autoimmunity. Here, we found that the alternative splicing of exons derived from transposable elements is a key mechanism controlling immune signaling in human cells. By analyzing long-read transcriptome datasets, we identified numerous transposon exonization events predicted to generate functional protein variants of immune genes, including the type I interferon receptor IFNAR2. We demonstrated that the transposon-derived isoform of IFNAR2 is more highly expressed than the canonical isoform in almost all tissues, and functions as a decoy receptor that potently inhibits interferon signaling including in cells infected with SARS-CoV-2. Our findings uncover a primate-specific axis controlling interferon signaling and show how a transposon exonization event can be co-opted for immune regulation.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.11.557241v1" target="_blank">Regulation of interferon signaling by transposon exonization</a>
</div></li>
<li><strong>Worldwide case of COVID-19 cabin fever as a motivator for conservation and sustainable action</strong> -
<div>
Exposure to nature is increasingly regarded as a key part of human health, and the recognition that urban environments must provide access to green spaces for the wellbeing of citizens. The beginning of the COVID-19 pandemic in 2020 led to many governments issuing stay-at-home orders and closing parks, limiting the options of accessible green spaces for people seeking to safely socialise and cope with stress. Here, we gain a global perspective on the speed people returned to nature (visiting parks and beaches) in comparison to necessities (accessing groceries and pharmaceuticals) and luxury activities (retail purchases and recreation) following COVID-19 lockdowns using Google Mobility data. Globally, we found that people returned to nature 30 days after returning to shop for essentials and 105 days to return to luxuries. Central Asia, Europe, and North America returned to nature before necessities. The rapidity with which people chose to spend time in nature indicates the value of these spaces to people and the need to increase access to them. However, the large-scale return to nature also highlighted the need to promote messages on how to minimise our impacts in these spaces. One strong way to motivate conservation and sustainability action is to ensure that people have access to nature and green spaces, which can foster pro-environmental behaviour.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/2ghu3/" target="_blank">Worldwide case of COVID-19 cabin fever as a motivator for conservation and sustainable action</a>
</div></li>
<li><strong>Predictors of COVID-19 Vaccine Acceptability Among Refugees and Other Migrant Populations: A Systematic Scoping Review</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objective. This study aimed to map the existing literature to identify predictors of COVID-19 vaccine acceptability among refugees, immigrants, and other migrant populations. Methods. A systematic search of Medline, Embase, APA PsycInfo and Cumulative Index of Nursing and Allied Health Literature (CINAHL) was conducted up to 31 January 2023 to identify the relevant English peer-reviewed observational studies. Two independent reviewers screened, selected studies, and extracted data. Results. We identified 34 cross-sectional studies, primarily conducted in high income countries (76%). Lower vaccine acceptance was associated with mistrust in the host countries9 government and healthcare system, concerns about the safety and effectiveness of COVID-19 vaccines, limited knowledge of COVID-19 infection and vaccines, lower COVID-19 risk perception, and lower integration level in the host country. Female gender, younger age, lower education level, and being single were associated with lower vaccine acceptance in most studies. Additionally, sources of information about COVID-19 and vaccines and previous history of COVID-19 infection, also influence vaccine acceptance. Vaccine acceptability towards COVID-19 booster doses and various vaccine brands were not adequately studied. Conclusions. Vaccine hesitancy and lack of trust in COVID-19 vaccines became significant public health concerns within migrant populations. These findings may help in providing information for current and future vaccine outreach strategies among migrant populations.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.09.15.23295608v1" target="_blank">Predictors of COVID-19 Vaccine Acceptability Among Refugees and Other Migrant Populations: A Systematic Scoping Review</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Assess the Safety, Tolerability and Preliminary Efficacy of HH-120 for the Treatment of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: HH-120;   Drug: placebo<br/><b>Sponsor</b>:   Huahui Health<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Investigate the Prevention of COVID-19 withVYD222 in Adults With Immune Compromise and in Participants Aged 12 Years or Older Who Are at Risk of Exposure to SARS-CoV-2</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2<br/><b>Interventions</b>:   Drug: VYD222;   Drug: Normal saline<br/><b>Sponsor</b>:   Invivyd, Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Additional Recombinant COVID-19 Humoral and Cell-Mediated Immunogenicity in Immunosuppressed Populations</strong> - <b>Conditions</b>:   Immunosuppression;   COVID-19<br/><b>Intervention</b>:   Biological: NVX-CoV2372<br/><b>Sponsors</b>:   University of Wisconsin, Madison;   Novavax<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reducing COVID-19 Vaccine Hesitancy Among Hispanic Parents</strong> - <b>Conditions</b>:   Vaccine-Preventable Diseases;   COVID-19 Pandemic;   Health-Related Behavior;   Health Knowledge, Attitudes, Practice;   Narration<br/><b>Interventions</b>:   Behavioral: Baseline surveys;   Behavioral: Digital Storytelling Intervention;   Behavioral: Information Control Intervention<br/><b>Sponsors</b>:   Arizona State University;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of Safety and Immunogenicity of a SARS-CoV-2(Severe Acute Respiratory Syndrome Coronavirus 2) Booster Vaccine (LEM-mR203)</strong> - <b>Conditions</b>:   COVID-19 Infection;   COVID-19 Vaccine Adverse Reaction<br/><b>Interventions</b>:   Biological: LEM-mR203;   Biological: Placebo<br/><b>Sponsor</b>:   Lemonex<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase I Safety Study of B/HPIV3/S-6P Vaccine Via Nasal Spray in Adults</strong> - <b>Condition</b>:   SARS-CoV-2 Infection<br/><b>Intervention</b>:   Biological: B/HPIV3/S-6P<br/><b>Sponsors</b>:   National Institute of Allergy and Infectious Diseases (NIAID);   Johns Hopkins Bloomberg School of Public Health;   National Institutes of Health (NIH)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Determine the Tolerability of Intranasal LMN-301</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: LMN-301<br/><b>Sponsor</b>:   Lumen Bioscience, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety of Simultaneous mRNA COVID-19 Vaccine With Other Childhood Vaccines in Young Children</strong> - <b>Conditions</b>:   Fever After Vaccination;   Fever;   Seizures Fever<br/><b>Interventions</b>:   Biological: Pfizer-BioNTech COVID-19 Vaccine;   Biological: Routine Childhood Vaccinations<br/><b>Sponsors</b>:   Duke University;   Kaiser Permanente;   Columbia University;   Children’s Hospital Medical Center, Cincinnati;   Centers for Disease Control and Prevention<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effect of Cognitive Behavioral Therapy on Post-Traumatic Stress Symptoms in Nursing Students</strong> - <b>Condition</b>:   Trauma and Stressor Related Disorders<br/><b>Intervention</b>:   Other: Cognitive Behavioral Therapy Group<br/><b>Sponsor</b>:   Necmettin Erbakan University<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Long COVID Immune Profiling</strong> - <b>Conditions</b>:   Long COVID;   POTS - Postural Orthostatic Tachycardia Syndrome;   Autonomic Dysfunction<br/><b>Interventions</b>:   Diagnostic Test: IL-6;   Diagnostic Test: cytokines (IL-17, and IFN-ɣ);   Behavioral: Compass 31<br/><b>Sponsors</b>:   Vanderbilt University Medical Center;   American Heart Association<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces</strong> - Since its emergence, the COVID-19 threat has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular dynamics simulations to examine the modulation of the fundamental interactions between the receptor binding domain (RBD) of the spike glycoprotein and the host cell receptor (human angiotensin-converting enzyme 2: hACE2) arising from Omicron variant…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Occurrence, formation, and proteins perturbation of disinfection byproducts in indoor air resulting from chlorine disinfection</strong> - Increased amounts of chlorine disinfectant have been sprayed to inactivate viruses in the environment since the COVID-19 pandemic, and the health risk from chemicals, especially disinfection byproducts (DBPs), has unintentionally increased. In this study, we characterized the occurrence of haloacetic acids (HAAs) and trihalomethanes (THMs) in indoor air and evaluated their formation potential from typical indoor ingredients. Subsequently, the adverse effect of chloroacetic acid on A549 cells was…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In silico evidences of Mpro inhibition by a series of organochalcogen-AZT derivatives and their safety in Caenorhabditis elegans</strong> - CONCLUSIONS: We have found that compounds S116l (a Tellurium AZT-derivative) and S116h (a Selenium-AZT derivative) presented more promising effects both in silico and in vivo, being strong candidates for further in vivo studies.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation</strong> - SARS-CoV-2 causes the severe respiratory disease COVID-19. Remdesivir (RDV) was the first fast-tracked FDA approved treatment drug for COVID-19. RDV acts as an antiviral ribonucleoside (adenosine) analogue that becomes active once it accumulates intracellularly. It then diffuses into the host cell and terminates viral RNA transcription. Previous studies have shown that certain nucleoside analogues unintentionally inhibit mitochondrial RNA or DNA polymerases or cause mutational changes to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Outcomes of a social media campaign to promote COVID-19 vaccination in Nigeria</strong> - The COVID-19 pandemic has been an historic challenge to public health and behavior change programs. In low -and middle-income countries (LMICs) such as Nigeria, there have been challenges in promoting vaccination. Vaccine hesitancy and social norms related to vaccination may be important factors in promoting or inhibiting not only COVID vaccination, but other routine vaccinations as well. The aim of this study was to conduct a national-level quasi-experimental evaluation of a social media based…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phytoconstituents as potential therapeutic agents against COVID-19: a computational study on inhibition of SARS-CoV-2 main protease</strong> - The Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) has become a global health crisis, and the urgent need for effective treatments is evident. One potential target for COVID-19 therapeutics is the main protease (Mpro) of SARS‑CoV‑2, an essential enzyme for viral replication. Natural compounds have been explored as a source of potential inhibitors for Mpro due to their safety and availability. In this study, we employed a…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Extracellular Vesicles and Endocannabinoid Signaling in Patients with COVID-19</strong> - Introduction: Endocannabinoids in COVID-19 have immunomodulatory and anti-inflammatory properties but the functional role and the regulation of endocannabinoid signaling in this pandemic disorder is controversial. To exercise their biologic function, endocannabinoids need to travel across the intercellular space and within the blood stream to reach their target cells. How the lipophilic endocannabinoids are transported in the vascular system and how these hydrophobic compounds cross cell…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase</strong> - Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main target for antiviral therapeutics due to its essential role in viral replication and transcription. Thus, nucleoside analogs structurally resemble the natural RdRp substrate and hold great potential as inhibitors. Until now, extensive experimental investigations have been performed to explore nucleoside analogs to inhibit the RdRp, and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2</strong> - Ebselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer’s, ebselen has demonstrated promising results. This review’s primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molnupiravir: an antiviral drug against COVID-19</strong> - SARS-CoV-2, the virus responsible for COVID-19, has caused numerous deaths worldwide and poses significant challenges. Researchers have recently studied a new antiviral drug called molnupiravir for treating COVID-19. This review examines the causes and immunopathogenesis of COVID-19, as well as the role of molnupiravir in its treatment. Molnupiravir is a prodrug of β-D-N4-hydroxyctytidine (NHC) and has demonstrated activity against various viruses, including MERS-CoV, SARS-CoV, SARS-CoV-2, and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Overreactive macrophages in SARS-CoV-2 infection: The effects of ACEI</strong> - Among various factors influencing the course of SARS-CoV-2 infection in humans, macrophage overactivation is considered the main cause of the cytokine storm that leads to severe complications of COVID-19. Moreover, the increased expression of angiotensin converting enzyme 2 (ACE2), an obligatory entry receptor of the coronavirus, caused by treatment with ACE inhibitors (ACEI) lowered overall confidence in the safety of these drugs. However, analysis of the course of coronavirus infection in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Omics data analysis reveals common molecular basis of small cell lung cancer and COVID-19</strong> - The impact of COVID-19 infection on individuals with small cell lung cancer (SCLC) poses a serious threat. Unfortunately, the molecular basis of this severe comorbidity has yet to be elucidated. The present study addresses this gap utilizing publicly available omics data of COVID-19 and SCLC to explore the key molecules and associated pathways involved in the convergence of these diseases. Findings revealed 402 genes, that exhibited differential expression patterns in SCLC patients and also play…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Whole genome CRISPR screening strategy to identify genes contributing to SARS-CoV-2 spike and VSV-G mediated entry</strong> - Understanding the cellular host factors that promote and inhibit viral entry is important for identifying viral countermeasures. CRISPR whole-genome screens can be used to rapidly discover host factors that contribute to or impair viral entry. However, when using live viruses and cellular lethality for selection, these screens can identify an overwhelming number of genes without specificity for the stage of the viral infection cycle. New screening methods are needed to identify host machinery…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>On a path toward a broad-spectrum anti-viral: inhibition of HIV-1 and coronavirus replication by SR kinase inhibitor harmine</strong> - RNA processing plays a key role in gene expression, allowing for increased protein diversity and functional complexity. Consequently, modulating RNA processing can impact gene function. Given HIV-1’s reliance on host RNA processing machinery for viral protein production/replication, modulators of this process could serve as novel anti-virals to complement and/or enhance existing therapies. In this study, screening of several serine-arginine-rich (SR) kinase inhibitors for their impact on HIV-1…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Association between levels of IgG antibodies from vaccines and Omicron symptomatic infection among children and adolescents in China</strong> - CONCLUSION: The risk of developing a symptomatic infection can be predicted independently by tertiles of IgG antibodies to wild-type SARS-CoV-2 antigens. High IgG levels can inhibit viral replication, vastly reduce the risk of symptomatic infections and promote a virus-negative conversion, especially when IgG quantitative detection was ≥3.44 S/CO, a potential threshold for protection and booster strategy in the future. More data and research are needed in the future to validate the predictive…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hasan Minhaj’s “Emotional Truths”</strong> - In his standup specials, the former “Patriot Act” host often recounts harrowing experiences he’s faced as an Asian American and Muslim American. Does it matter that much of it never happened to him? - <a href="https://www.newyorker.com/news/annals-of-communications/hasan-minhajs-emotional-truths">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Rage of the Toddler Caucus on Capitol Hill</strong> - Not even a Biden impeachment can soothe them out of a government shutdown. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/the-rage-of-the-toddler-caucus-on-capitol-hill">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A.I. and the Next Generation of Drone Warfare</strong> - The Pentagon’s Replicator initiative envisions swarms of low-cost autonomous machines that could remake the American arsenal. - <a href="https://www.newyorker.com/news/news-desk/ai-and-the-next-generation-of-drone-warfare">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Futility of the Never Trump Billionaires</strong> - Benjamin Wallace-Wells writes about the difficulties facing Republican Party factions that hope to put forth a nominee who can stand as a strong alternative to Donald Trump. - <a href="https://www.newyorker.com/news/daily-comment/the-futility-of-the-never-trump-billionaires">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lessons in Conquering Child Poverty</strong> - In the past few years, we’ve found out how to greatly reduce economic deprivation among the young, and how to greatly increase it. - <a href="https://www.newyorker.com/news/our-columnists/lessons-in-conquering-child-poverty">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The terrible paradox of air pollution and climate change</strong> -
<figure>
<img alt="A cartoon drawing of a sweaty person in a hardhat trying to vacuum up clouds from in front of a blazing sun. Exhausted flowers are in the foreground." src="https://cdn.vox-cdn.com/thumbor/Au_wMgWwdNn2M_T21OP-1mb1Avo=/0x0:1440x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72520941/AirPollution_MinHeo.0.png"/>
<figcaption>
Min Heo for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Some types of air pollution slow global warming — but at the cost of millions of deaths a year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CHAaMR">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QnBjmD">
“The smoke is very thick, like a dark mushroom in the sky,” <a href="https://books.google.com/books?id=FQkgAAAAIBAJ&amp;pg=PA18&amp;dq=mount+pinatubo&amp;article_id=5345,2519000&amp;hl=en&amp;sa=X&amp;ved=2ahUKEwiZ3LXizYmAAxWXEFkFHTCPCfgQ6AF6BAgIEAI#v=onepage&amp;q=mount%20pinatubo&amp;f=false">said</a> reporter Gus Abelgas in a 1991 television broadcast on the ongoing volcanic eruption of Mount Pinatubo in the Philippines. “It’s just like what we saw in Hiroshima.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IFRYuJ">
After <a href="https://pubs.usgs.gov/fs/1997/fs114-97/">500 years of dormancy</a>, Mount Pinatubo’s June explosion represented <a href="https://appliedsciences.nasa.gov/our-impact/story/remembering-mt-pinatubo#:~:text=By%20far%20the%20largest%20eruption,ash%20hundreds%20of%20miles%20across.">one of the largest volcanic events</a> of the 20th century. The eruption forced approximately 30,000 indigenous Aeta people to evacuate the nearby area and <a href="https://www.latimes.com/archives/la-xpm-1991-08-11-tm-798-story.html">killed</a> over 200 people. (An additional 426 people died in the three months following the explosion due to poor conditions in the evacuation zones.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E1pYGc">
The eruption also sent a sulfuric gas cloud into the atmosphere <a href="https://volcanoes.usgs.gov/volcanic_ash/pinatubo_1991.html">28 miles</a> high — or five Mount Everests <a href="https://www.livescience.com/tallest-mountain-on-earth#:~:text=Researchers%20have%20measured%20Mount%20Everest,miles%20(8.8%20kilometers)%20tall.">stacked</a> on top of each other. While <a href="https://archive.seattletimes.com/archive/?date=19910721&amp;slug=1295627">almost a foot</a> of muddy ash covered the surrounding area, the sulfuric gas <a href="https://earthobservatory.nasa.gov/images/1510/global-effects-of-mount-pinatubo">mixed</a> with water vapor in the air, creating a layer of a reflective acidic compound that cooled the Earth for two years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LIapTn">
Yes, that’s right: A hot volcanic eruption made the planet cooler.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uJCc3Y">
Sulfur dioxide is one of many aerosol particles that reflects the sun’s light and can act to make temperatures globally cooler than they would be otherwise. Mount Pinatubo’s eruption temporarily <a href="https://www.usgs.gov/observatories/hvo/news/volcano-watch-pinatubo-effect-can-geoengineering-mimic-volcanic-processes#:~:text=This%20aspect%20of%20Pinatubo's%201991,Fahrenheit)%20over%20the%20ensuing%20year.">dropped</a> global temps by about 0.9 degrees Fahrenheit. That doesn’t sound like a huge jump, but if you were to warm the planet by an additional 0.9 degrees Fahrenheit today, that could <a href="https://www.ipcc.ch/sr15/#:~:text=Robust%201%20global%20differences%20in,global%20warming%20(high%20confidence).">trigger</a> increased flooding and fire events, sweeping heat waves, super storms, and even famines.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GHkte2">
Collectively, volcanoes around the globe <a href="https://www.mtu.edu/news/2017/03/volcano-breath-measuring-sulfur-dioxide-space.html">emit 20 to 25 million tons</a> of the cooling aerosol sulfur dioxide annually, but in 1991, Mount Pinatubo alone <a href="https://www.nasa.gov/feature/goddard/2019/2018-s-biggest-volcanic-eruption-of-sulfur-dioxide">released</a> 15 million tons of the compound. And while extreme, Mount Pinatubo’s cooling effect is not an anomaly — nor are volcanoes the only sources.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YW6cZL">
Air-polluting sources — such as <a href="https://www.usgs.gov/programs/VHP/volcanoes-can-affect-climate">volcanic eruptions</a>, <a href="https://www.snexplores.org/article/wildfires-australia-siberia-california-cool-climate-aerosols#:~:text=They%20can%20cool%20the%20atmosphere,to%20compensate%20for%20global%20warming.">wildfires</a>, and <a href="https://climate.nasa.gov/explore/ask-nasa-climate/3271/aerosols-small-particles-with-big-climate-effects/#:~:text=Aerosol%20air%20pollution%20has%20made,1.5%C2%B0C)%20of%20warming.">industrial factories</a> — all emit particles that reflect light and cool the planet. To be absolutely clear: This is not at all to say that <a href="https://www.vox.com/air-quality">air pollution</a> is a good thing. Air pollution, after all, contributes to <a href="https://www.who.int/news/item/02-05-2018-9-out-of-10-people-worldwide-breathe-polluted-air-but-more-countries-are-taking-action">7 million premature deaths</a> per year globally. Improving air quality should be a top goal across the planet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ks1hnn">
“Many of those same human activities [that contribute to <a href="https://www.vox.com/climate">climate change</a>] can increase air pollution in the form of particles, and those particles are both detrimental to health and counteract, to some extent, the warming that comes from greenhouse gasses,” said Jason West, a professor in environmental sciences and engineering at the University of North Carolina at Chapel Hill.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JIBbko">
But in the absence of cooling aerosols, we might have nearly <a href="https://climate.nasa.gov/explore/ask-nasa-climate/3271/aerosols-small-particles-with-big-climate-effects/#:~:text=Aerosol%20air%20pollution%20has%20made,1.5%C2%B0C)%20of%20warming.">1 degree Fahrenheit </a>more warming, experts say. Given the world is on track to record its <a href="https://www.vox.com/climate/2023/7/5/23784587/hottest-day-heat-wave-recorded-temperature-climate-change">hottest summer</a> on record, this is bad news. While the positive effects of temperature-cooling pollution do not outweigh air pollution sources’ greenhouse gas emissions or the overall cost of these pollutants to human <a href="https://www.vox.com/science/2023/6/7/23752310/wildfire-air-quality-smoke-asthma-copd-lung-heart-disease">health</a>, they have acted to somewhat slow the rate of warming. As we reduce air pollution — which we must do — we need to be prepared for the short-term consequences of even faster global warming.
</p>
<h3 id="Bd816q">
The relationship between climate change and air pollution
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mRzhgO">
Greenhouse gas emissions — such as carbon dioxide, methane, and nitrous oxide — <a href="https://www.vox.com/2014/10/22/18093062/what-is-global-warming">warm</a> the planet by <a href="https://climate.mit.edu/ask-mit/how-do-greenhouse-gases-trap-heat-atmosphere">absorbing light</a> and therefore trapping heat. Electricity production (which has <a href="https://www.eia.gov/energyexplained/electricity/electricity-in-the-us-generation-capacity-and-sales.php">soared</a> over the last few decades) and vehicles are some of the <a href="https://www.epa.gov/ghgemissions/sources-greenhouse-gas-emissions#:~:text=Carbon%20dioxide%20(CO2)%20makes,natural%20gas%2C%20to%20produce%20electricity.">largest producers</a> of these gasses.
</p>
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Some aerosol particles — such as sulfate aerosols, particulate matter, and sea salt — prevent warming. Heat dances off bright-colored particles and is absorbed by darker particles (like <a href="https://climate.nasa.gov/explore/ask-nasa-climate/3271/aerosols-small-particles-with-big-climate-effects/">soot</a> and <a href="https://archive.ipcc.ch/publications_and_data/ar4/wg1/en/ch2s2-4-4-3.html#:~:text=Black%20carbon%20(BC)%20is%20a,BC%20is%20of%20anthropogenic%20origin.">black carbon</a>). Bright, reflective aerosol particles affect Earth’s temperature by <a href="https://earthobservatory.nasa.gov/features/Aerosols/page3.php">scattering</a> sunlight in the upper part of the atmosphere, the <a href="https://climate.nasa.gov/news/556/particles-in-upper-atmosphere-slow-down-global-warming/">stratosphere</a>. They also create and <a href="https://www.ox.ac.uk/news/2022-11-17-expert-comment-air-pollution-cools-climate-more-expected-making-cutting-carbon#:~:text=Collectively%2C%20these%20particles%20are%20called,%2C%20and%20potentially%20longer%2Dlasting.">brighten</a> clouds (which then also reflect light away from the Earth’s surface) by <a href="https://www.energy.gov/science/doe-explainsclouds-and-aerosols#:~:text=As%20air%20rises%20in%20the,the%20temperature%20of%20the%20air.">attracting water vapor</a> that attaches and sometimes freezes on the particles. The conglomeration of water vapor prompts the formation and thickening of clouds.
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Natural sources, such as volcanoes, sea spray, and desert storms, can <a href="https://www.nature.com/scitable/knowledge/library/aerosols-and-their-relation-to-global-climate-102215345/">shoot these particles</a> into the atmosphere. Human-made sources, like the <a href="https://pubs.acs.org/doi/10.1021/acs.est.1c05823#:~:text=With%20considering%20the%20fractionation%20effects,and%20oil%20combustion%20(1.7%25).">burning of coal</a>, also emit aerosols. Vehicles and power plants emit sulfate and nitrate particles.
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While greenhouse gas emissions can persist in the atmosphere for decades or even <a href="https://blogs.edf.org/climate411/2008/02/26/ghg_lifetimes/">centuries</a>, cooling aerosol particles live in the atmosphere for only <a href="https://www.gfdl.noaa.gov/aerosols-and-climate/">days or weeks</a> due to their composition and climate conditions. <a href="https://scied.ucar.edu/learning-zone/air-quality/aerosols#:~:text=Aerosols%20come%20in%20different%20sizes&amp;text=Larger%20particles%20tend%20to%20settle,the%20Earth's%20surface%20through%20precipitation.">Particle size</a> and <a href="https://www.epa.gov/climatechange-science/basics-climate-change">temperature</a> influence these emissions’ atmospheric lifespan. As Mount Pinatubo demonstrated, the effect of cooling aerosol particles is <a href="https://www.ox.ac.uk/news/2022-11-17-expert-comment-air-pollution-cools-climate-more-expected-making-cutting-carbon">temporary</a> (in the case of this massive volcanic eruption, the aerosol effect was felt for approximately two years) but they can be very strong. After the far larger eruption of Mount Tambora, 1816 became known as “<a href="https://www.nps.gov/articles/000/1816-the-year-without-summer.htm#:~:text=1816%2C%20also%20known%20as%20the,ground%20and%20the%20ocean's%20surface.">the year without a summer</a>,” as temperatures dropped by as much as 7 degrees Fahrenheit around the world, crops failed, and <a href="https://www.google.com/search?q=deaths+year+without+a+summer&amp;oq=deaths+year+without+a+summer&amp;aqs=chrome..69i57j33i22i29i30.3429j0j7&amp;sourceid=chrome&amp;ie=UTF-8#ip=1">tens of thousands of people died from hunger</a>.
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In 2018, researchers from the Center for International Climate and Environmental Research, <a href="https://www.vox.com/space">NASA</a>, the University of Leeds, the University of Oxford, and Climate Analytics <a href="https://agupubs.onlinelibrary.wiley.com/doi/full/10.1002/2017GL076079">found</a> that ending the emission of greenhouse gasses will also end human-caused aerosol emissions. The absence of these aerosols will result in global heating and increased rain, especially in locations where aerosol emissions were once regularly emitted. The world must prepare for a temporary spike in warmth in order to address the even more dangerous long-term effects of climate change and air pollution.
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If human-caused air pollution disappeared this instant, the world would experience the negative warming consequences of past greenhouse emissions for decades to come, with virtually no lingering cooling effect from the previously emitted particles, said West.
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“Let’s say we emitted greenhouse gases, CO2, and [aerosol cooling] particles at the same rate forever. Eventually, the greenhouse gases are going to win because they’re going to continue to accumulate,” he said. “Whereas the particle concentration would stay the same because it’s short-lived.” Ultimately, aerosol particles have masked some of greenhouse gasses’ effects, but they won’t do so forever.
</p>
<h3 id="xjv6fo">
Why we need cleaner air
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Despite evidence that keeping cooling aerosol particles from polluting sources would prevent some level of global warming, doing so is not an option. One, because they share a source with greenhouse gasses, and two, because they are unequivocally detrimental to human health.
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<a href="https://www.vox.com/climate/23769186/bad-air-quality-index-wildfires-pollution">Air Quality Index</a> (AQI) levels are used to <a href="https://www.vox.com/climate/23769186/bad-air-quality-index-wildfires-pollution">measure the level of air pollution</a> and range between 0 to 500. Even at relatively moderate levels (101-150 AQI), air pollution causes eye and throat irritation. But, as the intensity and length of exposure increase, so do the consequences.
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PM2.5, a type of fine-particle pollutant, is one of the <a href="https://www.vox.com/future-perfect/23757949/air-pollution-history-progress-clean-air-act-environmental-protection-agency-wildfires-smoke-smog">most harmful</a> air pollutants to human health currently regulated by the Environmental Protection Agency, and exposure to high levels can <a href="https://www.vox.com/future-perfect/2023/6/7/23752290/air-quality-levels-wildfire-smoke-clear-canada-ny-causes-aqi-health-symptoms">cause</a> heart attacks, strokes, and severe respiratory problems, and even initiate the onset of chronic conditions such as bronchitis and asthma. The effects are particularly dangerous for those suffering from <a href="https://www.vox.com/science/2023/6/7/23752310/wildfire-air-quality-smoke-asthma-copd-lung-heart-disease">preexisting lung and heart conditions</a> like obstructive pulmonary disease.
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“All the things we know that cigarette smoking can cause, like cardiovascular disease and lung cancer, likewise, fine particles do that,” said Patrick Kinney, a professor of urban health for Boston University’s School of Public Health. “Of course, we don’t breathe as much [fine particles] as a cigarette smoker does … but it’s the same kind of effect.”
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Infants and children are <a href="https://www.who.int/news-room/spotlight/how-air-pollution-is-destroying-our-health/10-things-to-know-about-air-pollution">particularly susceptible</a> to developing cancers and cognitive impairments due to air pollution. Low- and middle-income countries, primarily in Asia and Africa, account for more than <a href="https://www.who.int/news/item/02-05-2018-9-out-of-10-people-worldwide-breathe-polluted-air-but-more-countries-are-taking-action">90 percent of these deaths</a>.
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“When we look over the planet, aerosols can have a different influence,” said West. “We expect aerosols to have a bigger effect in the Northern Hemisphere — where most of the pollution sources are — compared to the Southern Hemisphere, which is relatively more pristine. It’s covered by ocean and there’s much less population.” Two-thirds of the African continent and most of Asia lie in the <a href="https://education.nationalgeographic.org/resource/hemisphere/">Northern Hemisphere</a>.
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<a href="https://www.adb.org/sites/default/files/publication/780921/air-quality-asia.pdf">Vehicle exhaust and coal combustion</a> contribute to particularly severe air pollution in densely populated areas within Asia. <a href="https://www.vox.com/china">China</a> and <a href="https://www.vox.com/india">India</a>, the <a href="https://worldpopulationreview.com/countries">two most populous countries</a> in the world, emit over <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375877/">half of the world’s PM2.5 emissions</a>, and in both countries, air pollution <a href="https://www.bbc.com/news/world-asia-india-61489488">contributes</a> to the deaths of more than 2 million people a year.
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“We need to switch away from <a href="https://www.vox.com/fossil-fuels">fossil fuels</a> toward <a href="https://www.vox.com/renewable-energy">renewables</a>,” said West, “which has benefits for both air pollution and for the climate.”
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What will happen to global temperatures?
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If humans keep burning fossil fuels, air pollution will worsen, and so will climate change. Consequently, a warmer planet will make our <a href="https://scied.ucar.edu/learning-zone/air-quality/air-quality-and-climate-change#:~:text=Because%20of%20climate%20warming%2C%20the,more%20often%20in%20hot%20temperatures.">air quality worse</a>. Hot weather <a href="https://scied.ucar.edu/learning-zone/air-quality/how-weather-affects-air-quality">creates</a> the perfect conditions for the reactions that produce ozone (a greenhouse gas). And heat waves can <a href="https://scied.ucar.edu/learning-zone/air-quality/how-weather-affects-air-quality">cause</a> droughts. During a drought, forest fires, which produce particle pollution, are more common. “Air pollution affects climate change and climate change affects air pollution,” said Kinney.
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But air pollution is not the only — or most important — byproduct of climate change, he added. Global warming will bring a host of other problems, including extreme <a href="https://www.vox.com/22538401/texas-heat-wave-weather-definition-record-temperature-climate-change">heat waves</a>, <a href="https://www.vox.com/21452781/zogg-fire-glass-wildfire-california-climate-change-hurricanes-attribution-2020-debate">hurricanes, wildfires</a>, and the <a href="https://www.vox.com/energy-and-environment/2020/7/7/21311027/covid-19-climate-change-global-warming-shifting-baselines">proliferation of infectious diseases</a>.
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“This is not new. We’ve had storms always and we’ve had heat waves always,” said Kinney. “But what climate change is doing is making those extremes more extreme, and pushing the sort of upper tail of the extreme distribution for temperature and also for storm intensity.”
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Across the world, <a href="https://www.vox.com/natural-disaster">natural disasters</a>, including extreme winter storms, wildfires, and flooding, are <a href="https://www.vox.com/climate/2023/7/13/23792409/floods-vermont-new-york-natural-disaster-insurance-global-climate-risk-change">wreaking havoc</a> on communities that previously never faced such events. “It’s worse than a new normal. I call it a new abnormal,” Michael Mann, a climate scientist at the University of Pennsylvania, <a href="https://www.vox.com/climate/2023/7/11/23791452/vermont-flooding-climate-change">previously told Vox</a>.
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Preventing further climate change is, therefore, the greatest concern, and given greenhouse gases and aerosol cooling particles often stem from the same sources, it’s very difficult to isolate the emissions.
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“There are some particles that are warming, such as black carbon particles. They have a warming influence, as well as being bad for health,” said West. “So if we can target black carbon-related emissions, then we could have a benefit for both problems — for both air pollution and health, and for climate. But … many sources are sources of both black carbon and cooling aerosols.”
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Even if the warming and cooling pollutants had different sources, the health outcomes from aerosol particles — heart attacks, strokes, chronic diseases — mean keeping them around isn’t a viable option.
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Thus, scientists and researchers are now looking for ways to mimic the cooling aerosol effect without the same negative impact through a practice known as <a href="https://geoengineering.environment.harvard.edu/geoengineering">geoengineering</a>. This field encompasses methods meant to offset the impacts of climate change by influencing the environment.
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One geoengineering method involves injecting salt particles into the air to <a href="https://research.noaa.gov/2021/10/13/this-solar-geoengineering-idea-has-a-goldilocks-problem/">brighten and increase cloud coverage</a> over the ocean. Despite research <a href="https://www.washington.edu/news/2012/01/25/injecting-sulfate-particles-into-stratosphere-wont-fully-offset-climate-change/">dating back to 2012</a> showing that salt particles cannot slow climate change at a meaningful rate, researchers continue to <a href="https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2019GL085838#:~:text=In%20light%20of%20global%20warming,sunlight%20away%20from%20the%20Earth.">explore</a> the idea.
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A number of other ideas have been proposed and tested, including <a href="https://www.usatoday.com/story/tech/science/2018/01/22/creating-clouds-stop-global-warming-could-wreak-havoc/1054026001/">producing artificial clouds</a> and placing <a href="https://www.independent.co.uk/tech/climate-change-solar-radiation-mirrors-geoengineering-b2291183.html">mirrors</a> in space. Producing clouds would entail <a href="https://www.usatoday.com/story/tech/science/2018/01/22/creating-clouds-stop-global-warming-could-wreak-havoc/1054026001/">shooting sulfur dioxide</a> (the same stuff Mount Pinatubo spat out) into the atmosphere, but initial studies of the practice showed that starting and then stopping the method could lead to dire unknown effects. The consequences of space mirrors seem less deadly but are also less understood, and embarking on such a program would <a href="https://www.independent.co.uk/tech/climate-change-solar-radiation-mirrors-geoengineering-b2291183.html">cost</a> trillions of dollars. All of these approaches are also politically contentious.
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While none of these methods is ready for wide-scale use, interest in geoengineering is rising. In late June, the <a href="https://www.vox.com/joe-biden">Biden administration</a> <a href="https://www.whitehouse.gov/wp-content/uploads/2023/06/Congressionally-Mandated-Report-on-Solar-Radiation-Modification.pdf">released a report</a> indicating the White House is open to geoengineering research aimed at cooling the planet, specifically the “scientific and societal implications of solar radiation modification.” No concrete plans or policies in this field have yet been made, indicating a level of necessary caution given concerns about geoengineering’s little-understood ramifications.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k1bvgf">
Altering the delicate balance of the Earth’s climate system through intentional intervention carries inherent risks, including <a href="https://www.pbs.org/newshour/science/geoengineering-to-combat-global-warming-may-harm-major-crops">crop</a> and <a href="https://www.carbonbrief.org/geoengineering-carries-large-risks-for-natural-world-studies-show/#:~:text=And%20the%20introduction%20of%20solar,the%20sharp%20change%20in%20conditions.">wildlife</a> die-offs and <a href="https://www.nature.com/articles/srep13055">unintended shifts</a> in weather patterns. Some methods could create massive <a href="https://www.theguardian.com/environment/2014/jan/08/geoengineering-drought-tropics-climate-change-volcano">droughts</a> in some parts of the world, or even <a href="https://www.pnas.org/doi/10.1073/pnas.1615572113#:~:text=Injecting%20sulfate%20aerosol%20into%20the,increase%20water%20vapor%20concentration%20causing">deplete the ozone layer</a> further.
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Another concern is “<a href="https://www.brookings.edu/articles/preparing-the-united-states-for-security-and-governance-in-a-geoengineering-future/">termination shock</a>.” If geoengineering technology went into effect and was then abruptly ended (by choice or by unpredictable events like terrorist attacks or natural disasters) then the resulting warming would be even more significant and catastrophic than current projections.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HI8Dcm">
Additionally, given that one country’s decision to engage in a geoengineering method could have global repercussions, scientists and policymakers <a href="https://www.brookings.edu/articles/preparing-the-united-states-for-security-and-governance-in-a-geoengineering-future/">continue to debate</a> the political repercussions and oversight of this technology.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rzrgnt">
And before any of these ideas can come to fruition, scientists and researchers must develop a better understanding of the true impact of the aerosol cooling effect.
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“We know that aerosol particles that come from human emissions have the potential to have a cooling effect on climate,” said Casey Wall, a postdoctoral researcher studying climate science at the University of Oslo. “And we know it can offset some of the warming effects from human greenhouse gas emissions. But the really big debate right now in the climate research community is just how much that aerosol cooling effect offsets the warming from greenhouse gases.”
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Air pollution’s relationship with and on climate change is complex, but at the end of the day, cleaner air will lead to a healthier planet. “Air pollution as we commonly talk about it is a bad thing overall, even though it has this effect of cooling the climate,” said Wall. “The effects on human health overall outweigh that.”
</p></li>
<li><strong>Should you be friends with your kids?</strong> -
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<img alt="An illustration of a silhouette of a child holding the hand of a silhouette of an adult. Both the child and the adult stand on a pink block. The blocks are separated by a small gap, and their clasped hands are held over the gap." src="https://cdn.vox-cdn.com/thumbor/O2HmxX2pBgf2TEA7gHYnZ46DTPw=/158x0:4835x3508/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72657109/GettyImages_1483667121.0.jpg"/>
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Getty Images/Westend61
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Parents can have a great relationship with their kids without being their friend.
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When it comes to raising children, there is no shortage of platitudes: “Parenting doesn’t come with an instruction manual,” “It’s a lifetime job,” “Children are always listening.” One question that endures in modern <a href="https://www.vox.com/parenting">parenting</a> culture is one about the relationship between parent and child — should you be friends with your kid?
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Part of the issue is the vagueness of the question: What does friendship with a child actually look like? Does being friends with your kids mean simply having fun together, or does it signify a relationship of equals? The <a href="https://www.apa.org/topics/friendship">American Psychological Association defines friendship</a> as “a voluntary relationship between two or more people that is relatively long-lasting and in which those involved tend to be concerned with meeting the others’ needs and interests as well as satisfying their own desires.” Parenting, however, isn’t voluntary, and a child shouldn’t be interested in meeting their parents’ needs.
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As parenting style has shifted away from “children should be seen and not heard” toward a family dynamic where children’s voices and opinions are valued, a tension remains regarding the balance between parental authority and childhood inclusivity. “There’s been a lot of movement in terms of what role do children play in the family dynamic,” says <a href="https://manhattanpsychologygroup.com/our-team/staff/francyne-zeltser-psyd/">Francyne Zeltser</a>, the director of <a href="https://www.vox.com/mental-health">mental health</a> and testing services Manhattan Psychology Group. “With children having more of a voice and having an opinion, how does that change the parent-child dynamic?”
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While experts stress the importance of a warm and supportive relationship with children, parents must maintain authority over their kids, which is directly at odds with the ideals of friendship. At its core, friendship is elective and equal. Once you’re a parent, there’s no opting out, making friendship not exactly appropriate for parents and their kids. So, should parents be friends with their little ones? In short: No. But you can still maintain aspects of friendship while remaining in the driver’s seat with little ones.
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<h3 id="RgxVDc">
Think about your parenting style
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There are <a href="https://www.cnbc.com/2021/06/29/child-psychologist-explains-4-types-of-parenting-and-how-to-tell-which-is-right-for-you.html">four styles of parenting</a> in the child <a href="https://www.vox.com/psychology">psychology</a> field that inform the relationship parents have with their kids: authoritarian, authoritative, permissive, and uninvolved. On opposite ends of the spectrum are uninvolved parents — absent and withdrawn — and authoritarian — demanding, strict, “my way or the highway.” In the middle are permissive parents, who are very loving but don’t enforce rules, and authoritative parents who set expectations and hold their children accountable, but explain their reasoning.
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“A parent that was ‘friends’ with their child would likely have more of a permissive parenting style,” Zeltser says, “where they would more likely go to great lengths to ensure that their child is happy, they would probably avoid conflict whenever possible. They might accommodate their child’s requests even if they’re not necessarily in agreement with their child’s requests to avoid disappointing their child. Those types of themes align much more with friendship than with a parent.”
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An authoritative parenting style, Zeltser says, is one that includes compromise and shared decision-making — the hallmarks of friendship — but with the adult holding the power to enforce rules. When children are younger and need more guidance and routine, there will be fewer negotiables; parents have the final say on bedtime, eating vegetables, or when it’s time to come home from a friend’s house. But it’s important to explain to kids why you’re making these decisions, Zeltser says.
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When parents are too lenient, they risk never teaching their children to hold themselves accountable and that there are consequences to their actions, says <a href="https://www.gottman.com/presenter/carrie-cole/">Carrie Cole</a>, the research director for the Gottman Institute and a certified Gottman therapist.
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<h3 id="oqIujV">
Being authoritative doesn’t mean unloving
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BmCGJN">
Acting as a friend to kids undermines a parent’s authority, says <a href="https://parentandteen.com/author/ginsburg/">Kenneth Ginsburg</a>, the founding director of the Center for Parent and Teen Communication, because a child may have a fear of disappointing you. Because friendship is conditional, companions may reject one another and end the relationship for any reason at all. For this reason, children may avoid coming to their parents for help because they don’t want to be rejected for doing something they perceive as wrong or bad. “The reality is that during adolescence, friendships can readily change and we worry so much as adolescents about not fitting in, or disappointing or losing our friends,” says Ginsburg, also the author of <a href="https://www.barnesandnoble.com/w/congrats-youre-having-a-teen-kenneth-r-ginsburg-md-msed-faap/1140374076"><em>Congrats — You’re Having a Teen! Strengthen Your Family and Raise a Good Person</em></a><em>.</em> “When we place our parents in that category, then we’re not going to use them in the way we really need to. Instead, we understand that parents are in a whole different category than friends. It’s guaranteed that they will stand by you.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MzIsjM">
Being accessible to your kids doesn’t mean dressing like them or only having fun together, Ginsburg says; it’s showing up for them when they’re having a disagreement with a friend or when they’re feeling <a href="https://www.vox.com/even-better/23844294/parents-help-kids-school-homework-bullying-mental-health">overwhelmed with school</a> and still loving them. Parenthood, rather than friendship, means never pushing them away or withholding love.
</p>
<h3 id="gJoPiw">
Set clear rules and expectations with children — but keep them involved
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LdLvMn">
Another crucial difference between friendship and parenting is, in friendship, both parties agree on a set of unspoken rules. Parents, on the other hand, should call all the shots with their kids, experts say. However, this doesn’t mean you can’t value your child’s opinions and wishes when it comes to those rules and expectations, says <a href="https://www.clarku.edu/faculty/profiles/wendy-grolnick/?id=223">Wendy Grolnick</a>, a professor of psychology at Clark University. “We call it autonomy support with structure,” she says. “Having structure, having some rules, some expectations, some guidelines. … [Parents] having some authority, but also supporting kids feeling like they have a say, like they’re active, they’re respected, their opinions count and get taken into account for real as you problem-solve together.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mMDDnd">
In <a href="https://www.sciencedirect.com/science/article/abs/pii/S0361476X21000989">studies</a>, Grolnick found that when parents were very strict and regimented with their kids when it came to homework and study time, chores, and other personal responsibilities at home, kids were more resistant to following their parents’ orders. However, in relation to safety — telling parents where you’ll be during unsupervised time, respecting curfew — kids were more accepting of concrete rules. “Kids are much more tolerant about parents setting the rules in areas that they see as areas of safety and morality,” Grolnick says, “versus things that they think are in their personal purview.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E4GyoL">
Instead of telling kids they can’t play video games until their homework is done, Grolnick suggests asking your child, “Let’s talk about what makes sense in terms of when homework should be done” and then give them choices. If you’d ideally like their homework to be completed before dinner time, ask your child when they’d prefer to do it: right when they get home from school or after they have a snack? “You listen to their opinion, you joint problem-solve, then you give them some choices about those rules and expectations,” Grolnick says. Parents should have the final say on some topics — for example, that homework is completed, or to treat others with respect — but all children, regardless of age, deserve some level of autonomy, Grolnick says, with the goal to make their choices age-appropriate.
</p>
<h3 id="rnfnJn">
Remember, parents need boundaries with their kids, too
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IlJv0R">
In an effort to relate with their children, some parents may fail to <a href="https://www.vox.com/even-better/23310442/vox-conversations-boundaries-nedra-glover-tawwab-even-better">set boundaries</a> or reinforce rules out of fear of upsetting their child, Cole says. But moments of disappointment can be learning opportunities for a kid. If a younger child is upset when you tell them it’s time to leave the park, help them identify those emotions. Cole suggests saying something like, “Yes, it makes sense that you would be disappointed that we have to go home now.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Uimuxv">
“Then we need to help them come up with some way to problem-solve,” Cole says. What is something your child is looking forward to when they get home? Or perhaps you can make a plan to go back to the park after school in a few days.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DPF5UH">
Setting and sticking to boundaries can be made easier by explaining why you’re making certain decisions, Zeltser says. There needs to be a clear reason beyond “because I’m the grown-up and I said so.” For example, if your child is frustrated when you ask them to clean up their toys, explain why, says <a href="https://www.bgsu.edu/arts-and-sciences/center-for-family-demographic-research/about-cfdr/research-affiliates/kei-nomaguchi.html">Kei Nomaguchi</a>, a professor of sociology at Bowling Green State University.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GoiNJl">
Be upfront with your children about your plans for the day so there are no surprises: Try saying, “We’re going to the park for two hours and then we’re going home for lunch.” That way, if you run into your kid’s friend in the park whose parents ask if your family would be interested in joining them for a meal, your child isn’t disappointed when you mention you already had alternative plans — or your kid is pleasantly surprised if you change your mind. “Now all of a sudden, the child’s reality exceeds their expectation,” Zeltser says. “They were thinking they were going to have to go home, now they could stay and spend more time with their friends. Now they’re elated.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YnwC4m">
Sometimes, when parents are divorced or separated, they’ll do whatever it takes to be liked by their children, Ginsburg says, and become more lax with rules or denigrate the other parent. “The message that kid is hearing is, oh my gosh, if I displeased this person, they might reject me too,” he says. Keep your children separate from the adult relationships, and the emotions that come with adult problems (regardless if divorce is involved) and don’t tell them anything you wouldn’t want them repeating to friends.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1bP64S">
Parents may also have the impulse to overshare with their children and to let them in on everything that’s going on. This may give the child a false impression that they sometimes need to take care of their parents, emotionally, Cole says. Even with teenagers, there needs to be a strong separation between the adult’s personal and parenting roles. For example, parents should not discuss their dating or sex life with their kids, no matter the child’s age, even if there is heartbreak involved. “The child should not be taking care of the parents in that way,” Cole says. Seek out the counsel of a trusted adult friend or mental health professional instead.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o8wroV">
All told, boundaries help kids maintain a routine, which is what they need, Nomaguchi says. “Too much freedom for kids is not really great for the family routine, and also family relationships, that seems to be what studies tend to show,” she says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KxDDqH">
As children age into adults themselves, you won’t need to have as much authority over your kids and their routines, and so you can adopt a relationship that veers closer toward friendship. However, when children are living at home, parents should stay in charge of the big-picture choices, but allow decisions to be largely collaborative. This helps kids feel like they have an ally in their parents, but — crucially — not a friend.
</p></li>
<li><strong>America’s most iconic coral reef is dying. Only one thing will save it.</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/rQpTTTTs0EtRqUUXt5ZUIlFTHFQ=/402x0:2962x1920/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72657052/adler_7028_1920x1080.0.jpg"/>
<figcaption>
Bleached elkhorn coral at Pickles Reef in the Florida Keys. | Jennifer Adler
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
An extreme heat wave has pushed Florida’s reef to the brink — and burned up years worth of progress.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MvHjs3">
PICKLES REEF, FLORIDA — As soon as our boat reached the reef, the problem appeared. Looking down<strong> </strong>through the clear, turquoise water, I saw a handful of stark white patches on the seafloor, some 20 feet below.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Hf2pB8">
I strapped on a tank, leapt into the ocean, and sank down near one of them. It was a large cluster of elkhorn coral, a threatened species that looks a bit like studded moose antlers sprouting from the reef. Normally, elkhorn is a vibrant, golden brown. Here it was bone white, a sunken skeleton.
</p>
<div class="c-wide-block">
<div class="c-image-grid">
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/hyKlNHS5z3N8k4vNvenn0THtvOg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925187/adler_6840__1_.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
A grouping of elkhorn coral at Pickles Reef that recently bleached due to extreme ocean temperatures.
</figcaption>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/K5gDe7-zR-ZkfNMAwEjIIjWV4vg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925205/adler_6877.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
Roxane Boonstra, the dive training administrator with an organization called the Coral Restoration Foundation, dives over a group of bleached elkhorn coral at Pickles.
</figcaption>
</figure>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KL3HAO">
As I cruised along Pickles Reef, which isn’t far from Key Largo, more species of corals came into view. Some looked like tree branches; others resembled spindly fingers that moved with the current. All of them were white. It was as if the reef had been dusted with a fresh coat of snow — beautiful, but haunting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7hxuzC">
In the world of coral biology, white is a bad color. It indicates that the corals, which comprise a colony of marine animals called polyps, have lost a kind of algae that lives within their bodies. Those algae give the corals most of their food and their brilliant color in exchange for nutrients and a place to absorb sunlight. White, or “bleached,” corals aren’t dead; they are starving to death.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nT5Kym">
The bleached corals I saw that afternoon at Pickles are a small part of a massive, ongoing tragedy: Across the Florida Keys and throughout much of the Caribbean, coral reefs have bleached and many of them are dying. Some of these starving corals are literally centuries old. Others were planted recently to revive the reefs, and their bleaching represents a devastating setback for coral restoration.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iVubFx">
The culprit is extreme heat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="npv5aZ">
In the last three months, a marine heat wave has been cooking the Caribbean, breaking down the relationship between coral and those symbiotic algae. Some shallow buoys in South Florida registered temperatures in excess of <a href="https://www.nytimes.com/2023/07/26/climate/florida-100-degree-water.html">100 degrees in July</a> — about as warm as a hot tub. And for weeks on end, reefs in the Florida Keys, the largest coral reef in the continental US, were soaking in 90-plus degree water. That’s well beyond the threshold for bleaching in this region.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/JLKqnCuLtWUkisZsgnpt6w0WEfQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925539/ezgif_1_8e10698c50.gif"/> <cite><a class="ql-link" href="https://coralreefwatch.noaa.gov/product/5km/index_5km_baa-max-7d.php" target="_blank">Coral Reef Watch/NOAA</a></cite>
<figcaption>
An animation showing the potential extent of bleaching in the last three months due to ocean warming. Yellow and orange colors indicate that bleaching is possible. Lighter red suggests significant bleaching is likely. Darker red indicates the likelihood of severe bleaching and coral death.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DVl3km">
“I’ve never seen anything like this in this area, period,” said <a href="https://www.aoml.noaa.gov/people/ian-enochs/">Ian Enochs</a>, a coral biologist at the National Oceanic and Atmospheric Administration, who’s been monitoring Florida’s reefs for more than a decade.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NeC7nb">
This mass bleaching event has made an already bad situation worse. Well before summer, the area of healthy reefs in the Florida Keys had already declined by <a href="http://www.climate.gov/news-features/features/mission-iconic-reefs-noaa-aims-restore-florida-keys-climate-resilient-corals#:~:text=Since%20the%20late%201970s%2C%20healthy,self%2Dsustaining%20levels%20by%202040.">90 percent</a>, due to past heat waves, diseases, ocean acidification, and other threats. The majority of Florida’s reefs that remain, meanwhile, are <a href="https://www.aoml.noaa.gov/study-finds-seventy-percent-of-floridas-coral-reefs-are-eroding/">eroding</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KVoMZr">
And the consequences of these declines are severe. Coral reefs function like seawalls, <a href="https://www.vox.com/down-to-earth/23046997/hurricane-ian-coral-reefs-climate-change-hurricanes">helping limit life-threatening storm surge during hurricanes</a>; they’re the engine of the region’s tourism economy; and they provide a home to as much as a quarter of all marine life including fish that people eat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BvGrkS">
The long-term outlook for coral reefs brings more bad news. As our cars and factories continue to blanket the Earth with carbon dioxide, heat waves will <a href="https://www.ipcc.ch/srocc/chapter/chapter-6/">become more common and intense</a>. Top climate scientists have <a href="https://www.vox.com/down-to-earth/2022/3/1/22954531/climate-change-ipcc-wildlife-extinction">warned</a> that warming could wipe out 70 to 90 percent of the tropical coral reefs worldwide. This is not just a problem in Florida. It’s a problem everywhere.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L8weGD">
This raises a difficult question: Does Florida’s reef — and coral reefs in similar dire situations around the world — have a future on our planet?
</p>
<div>
<div id="CSDIlB">
<div>
</div>
</div>
</div>
<hr class="p-entry-hr" id="WUBdXZ"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SNqRf3">
<strong>That afternoon in September</strong> wasn’t the first time I visited Pickles. I dived here in April of 2022 for a very different kind of story — one of hope.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dMWsMw">
At the time, underwater photojournalist <a href="https://www.jenniferadlerphotography.com/">Jenny Adler</a> and I <a href="https://www.vox.com/recode/23016412/coral-reef-restoration-climate-change">were documenting</a> local efforts to restore Florida’s ailing coral reefs. Restoration is akin to tree planting: Groups like the <a href="https://www.coralrestoration.org/">Coral Restoration Foundation</a> grow fragments of coral on structures in the open ocean, which they then “plant” on degraded reefs with an underwater adhesive. The effect is similar to planting saplings in a degraded forest — it gives the reef new life.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wJQsL4">
Diving in Pickles that spring, we saw large colonies of staghorn and elkhorn corals that CRF had planted a few years earlier. These older corals, which are both threatened species, had grown from small fragments into colorful, meter-wide structures. They were healthy and helped form a reef, shown below, like those that appear in postcards.
</p>
<div class="c-wide-block">
<div class="c-image-grid">
<div class="c-image-grid__item">
<figure class="e-image">
<img alt="Elkhorn corals (Acropora palmata) that were planted about 3 years ago." src="https://cdn.vox-cdn.com/thumbor/FeIzlKHOQZAHfot4lb15kh3Qc2M=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925209/adler_0298__1_.jpg"/>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/BOR4Lova_oCg7oMP6UYvBhGYr24=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925211/adler_0338__1_.jpg"/>
</figure>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pbYQWS">
Coral restoration was working, I thought. People were hopeful. Florida’s reefs were starting to grow back. It was a rare conservation victory.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7sTHbM">
Then came July.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bEeD16">
Here’s how the same location looks today. (The green tint on the corals below is algae that grows on colonies when they die. This is different from the good algae within healthy coral tissue).
</p>
<div class="c-wide-block">
<div class="c-image-grid">
<div class="c-image-grid__item">
<figure class="e-image">
<img alt="Similar elkhorn corals, but bleached white." src="https://cdn.vox-cdn.com/thumbor/wvvWC-5nKcJvgAgfGpxJ6pOV5pQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925234/adler_7252__1_.jpg"/>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt="Elkhorn corals planted about 3 years ago in the Florida Keys are now white and dying." src="https://cdn.vox-cdn.com/thumbor/vkkEgou5oYHdbnquczALEOV3cq0=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925238/adler_7347__1_.jpg"/>
</figure>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QlTd3K">
“It’s heartbreaking,” said Roxane Boonstra, the dive training administrator at CRF who took us diving at Pickles earlier this month. “I’ve been working in the coral field for what feels like my whole life and I’ve never seen bleaching on this scale.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cQNBYc">
In the last decade, CRF has planted more than 43,000 pieces of coral on Pickles. Since July, many of them have bleached or died, including nearly all the coral we saw.
</p>
<div id="wwlWVA">
<div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="drMHbh">
While Florida’s coral reefs have bleached several times before, this event is nonetheless<strong> </strong>historic. “We’re looking at a heat stress event that is in excess of two times greater than anything that’s ever been experienced in Florida on record,” Derek Manzello, a coral reef ecologist at NOAA, told me in August. Temperatures in South Florida were not only the <a href="https://www.noaa.gov/news/ongoing-marine-heat-waves-in-us-waters-explained">warmest on record</a>, but the heat started earlier and lasted longer than it did during past bleaching events, Manzello said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="36iB0o">
And it’s not only coral colonies in Florida that are suffering. Several other countries in the Caribbean and Latin America have also reported bleaching this summer including Mexico, Belize, and Puerto Rico. Many local communities in these regions are <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164699">highly dependent</a> on coral reefs for food or for work. “We’re talking about thousands upon thousands of miles of coral reefs undergoing severe bleaching heat stress,” Manzello <a href="https://research.noaa.gov/2023/08/15/media-resources-deeper-dive-into-coral-bleaching-event/">told reporters</a> in mid-August.
</p>
<div class="p-fullbleed-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/7k7TSMn_iNUrDpBZsQT1-TwI1IU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925243/adler_4996__1_.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
Bleached soft corals cover large portions of the seafloor at a reef called Eastern Dry Rocks in the south Florida Keys.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zCdAr5">
Some reefs in the Keys are much worse off than others, especially those that are shallow. On a warm weekday morning, we boated out to a reef off the coast of Key West called Eastern Dry Rocks. It’s one of seven sites that are part of <a href="https://marinesanctuary.org/mission-iconic-reefs/">Mission: Iconic Reefs</a>, a multimillion-dollar effort involving NOAA, CRF, and other groups to resurrect reefs in this region.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6unWTb">
After a smooth 20-minute ride, we suited up and dropped down to the bottom, 15 feet below. Bailey Thomasson, who leads restoration here for CRF, toured us around, showing us coral after coral that her team had planted. Some were small, about the size of a hand; others stretched a couple of feet above the reef.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="trbUNX">
They were nearly all dead and coated in algae or bone white and bleached. It was as if a white plague had spread across the reef.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/RmrHHiTMee1pTizEHkU7Lro0eM8=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24926989/Benji_Coral.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r60Kg6">
I did see a handful of neon green and blue corals, which popped against the monochrome reef. This was a good sign, I thought. But back on the boat, Thomasson explained that they, too, were bleached. Some corals produce bright pigments that function as sunscreen to protect themselves (and possibly to also attract those important algae partners that they lost). What I saw wasn’t a healthy color — it was a sign of dire stress.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fRH0cm">
Seeing all this bleaching is not only gut-wrenching, but it also points to an obvious challenge with restoration: Organizations are putting corals into an ocean that’s killing them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T6ECFi">
This challenge is not lost on researchers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GCEGKR">
“Restoration as we currently do it is not working in Florida,” Enochs of NOAA told me. “The fact that we are putting out corals that are ultimately just going to die is, in my opinion, irresponsible.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YYUwUg">
This doesn’t make restoration pointless, several scientists told me. It just underscores the need to do it a bit differently.
</p>
<hr class="p-entry-hr" id="DhmWnM"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="p2CBRk">
<strong>Our dives weren’t all bleak.</strong> A large patch of staghorn coral at Pickles looked healthy. It was an orangey beige and its tentacles were poking out (coral polyps are a bit like sea anemones with stinging tentacles around a mouth). Elkhorn corals in CRF’s coral nursery, where the group raises corals to plant, were colorful and healthy, too, resembling pieces of fried chicken dangling from PVC and fiberglass structures.
</p>
<div class="c-wide-block">
<div class="c-image-grid">
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/LUE-ncT-sGoZlN6RhgndlqlyFDg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925271/adler_7679.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
Boonstra examines a “tree” of healthy elkhorn coral at CRF’s Tavernier nursery, the world’s largest coral nursery in the ocean.
</figcaption>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/ZO2VWyA0NF46xqipgGqhSwOm-SE=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925436/adler_7984__1_.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
Beth Vessels, who does communications for CRF, diving through the “trees” at Tavernier.
</figcaption>
</figure>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ryhha1">
This is key: Some coral colonies tolerate heat better than others.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HueRAX">
Why? Research has shown that thermal tolerance among corals is, to an extent, <a href="https://www.science.org/doi/10.1126/sciadv.abg6070?cookieSet=1">genetically based</a>, and resistance to other threats like disease may be rooted in their DNA, as well. And it’s this fact that underlies the future of coral restoration. Scientists essentially want to plant corals on the reef with underlying genetics that give them a leg up.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xDFlXs">
One way they do this is by helping corals breed and produce coral babies. It’s a numbers game: The more genetically distinct babies you have, the more likely it will be that some of them are tolerant to extreme heat, disease, or other threats.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sUPgWL">
This approach is important in a place like Florida, where the reef is so damaged that corals have trouble breeding on their own. Corals breed by spawning: Once a year, a set number of days after a full moon, colonies puff out bundles of sperm and eggs (or just sperm <em>or</em> eggs, or in some cases, larvae). In order for the eggs of one individual to be fertilized, they have to encounter the sperm of another. But there are so few healthy corals in Florida that their spawn often don’t meet.
</p>
<div class="c-float-right">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/PhaNgYmU_wRPoPAIqoPhI3vQXBU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925319/adler_2461__1_.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
Celia Leto, a staff biologist at Mote Marine Laboratory and Aquarium, peers into a tank of elkhorn coral to see if any of them are spawning. She uses a red light because it doesn’t disturb the corals.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QAgcSx">
That’s where self-described “coral baby doctor” Hanna Koch comes in. A scientist at the Mote Marine Laboratory and Aquarium, Koch, who’s both serious and prone to laughter, coaxes coral parents into spawning in giant tanks on land. She and Celia Leto, a staff biologist, use that spawn to produce genetically diverse coral babies — nearly invisible to the naked eye — which Mote will eventually plant on local reefs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U0IOZl">
The idea here is that some of those babies will survive extreme heat or other stresses and give rise to the next generation. “We are restoring our reef with corals that have the best possible chances of surviving and coping with continued environmental stress,” Koch told me.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TNDI4v">
This approach produces a diverse crop of babies with varied traits. But scientists can also breed corals for a single trait, such as heat tolerance, in the same way that a farmer might breed fruits to make them sweeter. This method is known as selective breeding.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yuCfxX">
Breeding two corals that can survive extreme heat tends to produce babies that also have built-in heat tolerance. What’s more, scientists can breed algae symbionts — the organisms that live inside healthy corals — to be more heat tolerant, as well. “It’s like bartending,” Kate Quigley, a coral ecologist, said of selective breeding corals. “You’re just mixing things in different proportions.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uIw1bi">
A researcher at Australia’s Minderoo Foundation, Quigley <a href="https://www.nature.com/articles/s41467-022-28956-8">has shown</a> that it’s possible to selectively breed some corals and their algae to withstand slightly higher temperatures over a few weeks, potentially increasing the survival of corals <a href="https://www.nature.com/articles/d41586-021-01753-x#:~:text=Breeding%20the%20host%20coral%20for,it%20is%20no%20silver%20bullet.">by 26-fold</a> when oceans warm up. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378819/">Other research</a> has shown that even if just one parent has a higher heat tolerance it will produce more thermally tolerant babies.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/KKvwvOXPlZvb3otZW7XiZJLST90=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925358/adler_2482__1_.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
Baby corals under a microscope at Mote. Some species fluoresce under UV light.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UKWdGL">
Selective breeding may sound great, but it has some major limitations. For one, the process is slow and hard to scale up; corals take years to grow and reach a size where they can spawn. Plus, you can only tweak a coral’s traits by so much. “There is a hard ceiling to the biology,” Quigley said. Researchers may be able to stretch the coral’s heat tolerance by a few degrees, but it almost certainly won’t be enough for them to cope with future heat waves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wAE6u7">
That brings us to the biggest problem of all: Even the most advanced restoration efforts are only temporary solutions. They’re just <a href="https://www.nature.com/articles/s41598-022-26930-4">buying time</a>. The only true solution, roughly a dozen experts told me, is for countries and companies to quickly ramp down their carbon emissions. Even then, aggressive restoration will still be needed to help reefs hold on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="874QOV">
“People will criticize restoration, asking why we are throwing millions of dollars at this effort that’s going to fail,” Boonstra of CRF said. “Well, it’s only going to fail if you think that this is all that’s needed. All we’re trying to do is keep things alive until other people take the big hard steps that are necessary.”
</p>
<hr class="p-entry-hr" id="1JqepL"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uATWrd">
<strong>By the time Jenny and I arrived</strong> in Florida, the water had cooled down from the summer peaks by several degrees. It was in the mid-80s — near the upper limit of what corals can tolerate. Yet it’s still hot. And even if the water does cool down, as it should as the year progresses, recovering corals can still be prone to disease and struggle to reproduce.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w70OpG">
So where does that leave the Florida Keys? Is it doomed?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YG9yeb">
It will be months before researchers do a full assessment of this summer’s bleaching. Some deeper reefs, and those farther north, are better off and may have avoided bleaching, scientists say. But in the short term, it’s not looking great.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6SEYK1">
Over the long term, as heat waves intensify, it’s unlikely that coral will disappear altogether. Some species are hardier, such as a type of soft coral called sea fans; they’re important to wildlife but don’t build reefs in the same way as hard corals. Ultimately, it’s just a question of what future reefs will look like — degraded, and providing little value to humans and marine animals, or full of life and beauty, as they once were.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="H9y5MH">
“I think it’s likely that reefs are going to persist in the future,” said Liam Lachs, a doctoral researcher at Newcastle University who has studied heat tolerance in corals. “The question is, what’s the composition of the reefs? Do they still provide the services that they had historically provided?”
</p>
<div class="c-float-right">
<div id="FZFg75">
<div>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sdlSu6">
For now, even in its bleached and dying state, parts of the reef are still holding on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oRFyFO">
Around 9:30 pm on a clear night, Jenny and I were gearing up to dive on Looe Key, another spot with substantial bleaching. This was a critical moment: We were here to see if any wild corals on the reef would spawn, perhaps leading to a new generation of corals with new genetic diversity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="haPDx4">
It felt like a long shot. Corals only spawn once a year for a few minutes, typically in the middle of the night, and they’re unlikely to reproduce if they’re bleached or otherwise stressed out. To see spawning here would be “miraculous,” said Koch, who was with us that night, “given the scope and scale of degradation and devastation.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Yjge0F">
At night underwater, sea critters that are typically hiding during the day come out. A 4-foot stingray cruised the seafloor under the beam of my flashlight. Lobster antennae poked out of dark crevices. A small moray eel, its mouth wide open, waited for a hapless fish to swim by. Dozens of henchmen-like barracudas lurked above me.
</p>
<div class="c-float-left c-float-hang">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/Oj-zBLLc9tPapXIQ6Jg-5Lp-i_8=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925362/adler_6305__1_.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
Hanna Koch and Celia Leto of Mote Marine Laboratory stare at a colony of lobe star coral under the beams of red and white flashlights.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P2J9fZ">
Hovering in pairs next to healthy corals, we waited, our bodies rising and falling with every breath. When our air ran low, we popped up to the surface, switched out our tanks, and swam back down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u5Xd4m">
Now it was around 10:30 and we were on our third dive of the night. The water around us sparkled with bioluminescent critters. Then I saw a light flashing frantically a few meters away. I swam over to find Koch and Leto staring closely at a large mound of a knobby brown coral. They pointed ecstatically.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jU1PLr">
With all of us in a circle around the coral, the show began. Section by section, the colony — a species known as lobe star coral — began to expel little pink balls, like an upside down salt shaker. They hovered above the coral for a second before getting swept away by the current.
</p>
<div class="p-fullbleed-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/KMyX2hZ2-8_LZiZ1PfoWNJwcT4Y=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24925370/adler_6604__1_.jpg"/> <cite>Jennifer Adler</cite>
<figcaption>
A mound of lobe star coral spawns after 11 pm at Looe Key reef on September 6.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7kowRR">
In each of those balls were several eggs and millions of sperm. If all goes well, they’ll drift around the ocean until they cross paths with the sperm and eggs of another coral that also spawned that night. Together, they’ll produce coral larvae that will swim to the ocean floor and start a colony of their own, creating the next generation of coral in the Florida Keys — assuming it’s not too hot for them to thrive.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PPjNT3">
<em>Jennifer Adler contributed reporting.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CSQT4B">
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ashwa Morocco claims the Chief Minister’s Cup</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Snowfall, Magileto and Scaramanga impress</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Highly-rated Rudrankksh Patil keen to add Asian Games medal to his tally</strong> - Ranked fifth in the world, Rudrankksh in 2002 became only the second Indian to win a World Championship gold in the 10m Air Rifle after Bindra in 2006 and has been in constant touch with the latter</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical India thrashes Sri Lanka by 10 wickets to lift Asia Cup title for eighth time</strong> - Mohammed Siraj bowled splendidly to trouble the Sri Lankan top order batsmen and took 6 for 21</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bopanna ends Davis Cup career on a high, India wins 3-1 against Morocco</strong> - An emotional Bopanna rested his India-shirt on the court, marking the end of his Davis Cup career in which he played 33 ties, winning a total of 23 matches including 13 in doubles.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>24 NCC girl cadets to participate in All India Thal Sainik camp in New Delhi</strong> - The girls have been hand-picked from 30,000 cadets who underwent a training-cum-selection process at the NCC Tirupati group headquarters over 10 weeks</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Finance Minister Nirmala Sitharaman celebrates artisans’ contribution to India’s economy</strong> - In an address, Ms. Sitharaman underlined the invaluable role of artisans and craftsmen in shaping India’s self-sufficiency and prosperity.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBI arrests seven, including Bridge &amp; Roof Company official, on graft charge</strong> - The case alleges a conspiracy to get the tender of Eklavya Model Residential School, Odisha.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prime Minister not giving appointment to all-party delegation, says CM Siddaramaiah</strong> - “I want to take an all-party delegation to the Prime Minister and discuss crucial issues,” Mr. Siddaramaiah said.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Food delivery partners’ double whammy: Decreasing income levels, rising petrol costs | Data</strong> - While the real monthly income of food delivery workers fell from ₹13,500 a month in 2019 to ₹12,000 in 2022, fuel costs as a share of their income increased from 28.7% to 37.5% in the same period</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine’s Crimea attacks seen as key to counter-offensive against Russia</strong> - This week’s attacks against Russian targets are part of increased efforts to cut supply lines.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>First grain ships arrive in Ukraine using new route</strong> - Officials say the vessels will deliver 200,000 tonnes of wheat to world markets.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lampedusa: Ursula von der Leyen and Giorgia Meloni visit island after migrant boat fears</strong> - More than 8,000 migrants have arrived on the Italian island over the past three days.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Turin: Girl, 5, killed after Italian military jet crash</strong> - Video footage appears to show the pilot ejecting from the plane as it starts to fall from the sky.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Luis Rubiales given Spanish restraining order over World Cup kiss</strong> - Prosecutors asked the court to bar Spain’s ex-football president from approaching player Jenni Hermoso.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NASA clears the air: No evidence that UFOs are aliens</strong> - NASA attempts to make conversations about aerial phenomena more scientific. - <a href="https://arstechnica.com/?p=1968866">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Toddler poisoned after eating deadly plant mislabeled as diet supplement</strong> - Nine out of 10 Tejocote Root products tested were actually deadly yellow oleander. - <a href="https://arstechnica.com/?p=1968912">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Funky AI-generated spiraling medieval village captivates social media</strong> - “This was the point where AI-generated art passed the Turing Test for me.” - <a href="https://arstechnica.com/?p=1968790">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“Most notorious” illegal shadow library sued by textbook publishers [Updated]</strong> - Previous efforts to unmask the people behind Libgen have failed. - <a href="https://arstechnica.com/?p=1968849">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Musk’s X revokes paid blue check from United Auto Workers after strike called</strong> - After a report called out Musk’s union-busting, UAW’s blue check got reinstated. - <a href="https://arstechnica.com/?p=1968789">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A guy stuck his head into a barbershop and asked, “How long before I can get a haircut?” The barber looked around the shop full of customers and said, “About 2 hours.” The guy left.</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A week later, the same guy stuck his head in the shop and asked, “How long before I can get a haircut?” The barber looked around the shop and said, “About an hour and a half.” The guy left.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The barber turned to his friend and said, “Hey, Bob, do me a favor, follow him and see where he goes. He keeps asking how long he has to wait for a haircut, but he never comes back.” A little while later, Bob returned to the shop, laughing hysterically. The barber asked, “So, where does he go when he leaves?” Bob looked up, wiped the tears from his eyes and said, “Your house!”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/16kh0qo/a_guy_stuck_his_head_into_a_barbershop_and_asked/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/16kh0qo/a_guy_stuck_his_head_into_a_barbershop_and_asked/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A 60 year millionaires is getting married. His friends are jealous and one of them ask how he landed such a hot 23 year old blonde beauty…</strong> - <!-- SC_OFF --></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Simple”, grins the millionaire.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
" I faked my age".
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
His friends are really amazed and ask him what age he told her…
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
he replies: " I said i was 87"
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MarcoDanielRebelo"> /u/MarcoDanielRebelo </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/16k8aao/a_60_year_millionaires_is_getting_married_his/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/16k8aao/a_60_year_millionaires_is_getting_married_his/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A preacher was making his rounds to his parishioners on a bicycle when he came upon little Johnny trying to sell a lawn mower.</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“How much do you want for the mower?” asked the preacher.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I just want enough money to go out and buy me a bicycle,” said little Johnny.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After a moment of consideration, the preacher asked, “Will you take my bike in trade for it?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Little Johnny said, “Mister, you’ve got yourself a deal.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The preacher took the mower and tried to start it. He pulled and pulled on the rope until he was dripping with sweat but the mower refuses to start.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The preacher called little Johnny over and said, “I can’t get this mower to start.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Little Johnny said, “That’s because you have to cuss at it to get it started.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The preacher said, “I’m a man of the church and I can’t cuss. It’s been so long since I’ve been saved that I don’t even remember how to cuss.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Little Johnny looked at him happily and said, “Just keep pulling on that rope. It’ll come back to ya.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Gil-Gandel"> /u/Gil-Gandel </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/16kcejf/a_preacher_was_making_his_rounds_to_his/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/16kcejf/a_preacher_was_making_his_rounds_to_his/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An old man calls his son and says, “Listen, your mother and I are getting divorced. Forty-five years of misery is enough.”</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Dad, what are you talking about?” the son screams.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“We can’t stand the sight of each other any longer,” he says. “I’m sick of her face, and I’m sick of talking about this, so call your sister and tell her,” and he hangs up.
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Now, the son is worried. He calls his sister. She says, “Like hell they’re getting divorced!” She calls their father immediately. “You’re not getting divorced! Don’t do another thing. The two of us are flying home tomorrow to talk about this. Until then, don’t call a lawyer, don’t file a paper. DO YOU HEAR ME?” She hangs up the phone.
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The old man turns to his wife and says, "Okay, they’re both coming for Christmas and paying their own airfares.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/IdeaCafe"> /u/IdeaCafe </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/16jzbhm/an_old_man_calls_his_son_and_says_listen_your/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/16jzbhm/an_old_man_calls_his_son_and_says_listen_your/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I just found out there’s an actual clinical name for when you can’t sleep at night and just eat instead</strong> - <!-- SC_OFF --></p>
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It’s called insomnomnomnomia
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/mutilatedxlips"> /u/mutilatedxlips </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/16kwqhc/i_just_found_out_theres_an_actual_clinical_name/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/16kwqhc/i_just_found_out_theres_an_actual_clinical_name/">[comments]</a></span></p></li>
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