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+ + + ++Introduction There is an urgent need for more efficient models of differentiated antiretroviral therapy (ART) delivery for people living with HIV (PLHIV), with the World Health Organization calling for evidence to guide whether annual ART prescriptions and consultations (12M scripts) should be recommended in global guidelines. We assessed the association between 12M scripts (allowed temporarily during the COVID-19 pandemic) versus standard 6-month prescriptions and clinical review (6M scripts) and clinical outcomes. Methods We performed a retrospective cohort study using routine, de-identified data from 59 public clinics in KwaZulu-Natal, South Africa. We included PLHIV aged >18 years with a recent suppressed viral load (VL) who had been referred for community ART delivery with 6M or 12M scripts. We used modified Poisson regression to compare 12-month retention-in-care (not >90 days late for any visit) and viral suppression (<50 copies/mL) between prescription groups. Results Among 27,148 PLHIV referred for community ART between Jun-Dec 2020, 42.6% received 6M scripts and 57.4% 12M scripts. The median age was 39 years (interquartile range [IQR] 33-46) and 69.4% were women. Age, gender, prior community ART use and time on ART were similar in the two groups. However, more of the 12M script group had a dolutegravir-based regimen (60.0% versus 46.3%). The median (IQR) number of clinic visits in the 12 months of follow-up was 1(1-1) in the 12M group and 2(2-3) in the 6M group. Retention at 12 months was 94.6% (95% confidence interval [CI] 94.2%-94.9%) among those receiving 12M scripts and 91.8% (95% CI 91.3%-92.3%) among those with 6M scripts. 17.1% and 16.9% of clients in the 12M and 6M groups were missing follow-up VL data, respectively. Among those with VLs, 91.0% (95% CI 90.5%-91.5%) in the 12M group and 89.7% (95% CI 89.0%-90.3%) in the 6M group were suppressed. After adjusting for age, gender, ART regimen, time on ART, prior community ART use and calendar month, retention (adjusted risk ratio [aRR]: 1.03, 95% CI 1.01-1.05) and suppression (aRR: 1.01, 95% CI 1.00-1.02) were similar in the prescription groups. Conclusions Wider use of 12M scripts could reduce clinic visits without impacting short-term clinical outcomes. +
++This paper presents results from the Smart Healthy Campus 2.0 study/smartphone app, developed and used to collect mental health-related lifestyle data from 86 Canadian undergraduates January – August 2021. This was a longitudinal repeat measures study conducted over 40 weeks. A 9-item mental health questionnaire was accessible once daily in the app. Two variants of this mental health questionnaire existed; the first was a weekly variant, available each Monday or until a participant responded during the week. The second was a daily variant available after the weekly variant. Mixed models were fit for responses to the two variants and 12 phone digital measures (e.g. GPS, step counts). A second round of models was fit based on backward elimination to determine associations between the 12 digital measures and the variants. 6518 digital measure samples and 1722 questionnaire responses were collected. The daily questionnaire had positive associations with floors walked, installed apps, and campus proximity, while having negative associations with uptime, and daily calendar events. Daily depression had a positive association with uptime. Daily resilience appeared to have a slight positive association with campus proximity. The weekly questionnaire variant had positive associations with device idling and installed apps, and negative associations with floors walked, calendar events, and campus proximity. Physical activity, weekly, had a negative association with uptime, and a positive association with calendar events and device idling. SHC 2.0, via phone digital measures, identified indicators of lifestyle that appeared to be associated with measures of mental health in undergraduates during COVID-19. +
++This cohort study aimed to evaluate the protection against symptomatic SARS-CoV-2 infection conferred by the Pfizer-BioNTech Original/BA.4-5 bivalent vaccine compared to mRNA Original (ancestral) monovalent vaccines. Individuals of ≥60 years old who received a booster dose between 03/10/2022 and 06/11/2022, when both the bivalent and monovalent vaccines were used in France, were included. Individuals who received a booster dose with (1) a monovalent Original mRNA vaccine (Pfizer- BioNTech or Moderna) or (2) the bivalent Pfizer-BioNTech Original/BA.4-5 vaccine were matched. The outcome of interest was a positive SARS-CoV-2 RT-PCR or antigenic test associated to self-reported symptoms, at least seven days after receiving the booster dose. Data were analysed with a Cox Proportional-Hazards model adjusted for the presence of previous infection, age, sex, and the presence of medium risk comorbidities. A total of 136,852 individuals were included and followed for a median period of 77 days. The bivalent vaccine conferred an additional protection of 8% [95% CI: 0% - 16%, p=0.045] against symptomatic SARS-CoV-2 infection compared to the monovalent vaccines. +
++Image analysis software is used in the review process to detect research misconduct (1), but not for positive motives (e.g., for missing findings). Also, scientists analyze ″raw images″ (e.g., MRI), but there are no methods for published ″charts.″ So, we conceived an analysis method. We applied our idea to two cardiovascular data related to thrombosis (traveler′s or travel-related thrombosis and COVID-19) because there are still controversial discussions that might be due to some overlooked information. We found overlooked an approximately 28 days cycle of thrombosis onset over several weeks after travel in a figure (Cannegieter et al., PLoS Med. 2006, in the top 25% of all research scored by Altmetric) (2). Also, we found an eighteen-day cycle of thrombosis onset in another chart (Kelman et al., BMJ. 2003, in the top 5% of research) (3). In COVID-19, we found overlooked subgroup patterns in a scatterplot of Troponin T and NT-proBNP (Guo et al. JAMA Cardiol. 2020, top 5% research) (4), which has already appeared in the cardiomyopathy study in 2016 (Budnik et al., Int J Cardiol. 2016) (5). The above cyclic patterns suggested that travel-related oral contraceptive initiation (e.g., honeymoon and OC initiation) or hormone replacement therapy caused thrombosis. Also, the in-flight environment can likely not explain the cyclic patterns. In conclusion, women′s life-stage-related events, which are also related to travel, may be the underlying cause. In COVID-19, biomarker data should require a re-analysis. Our findings in the well-known figures suggest that our tips can be an essential review technique. +
++Background: In general, COVID-19 vaccines are safe and effective, but minor adverse effects are common. Objective: To estimate the prevalence of adverse effects after the first COVID-19 booster dose, and to identify possible risk factors. Material and methods: We conducted a cross-sectional study with a convenience sample in Greece during November 2022. We measured several adverse effects after the booster dose, such as pain at the injection site, swelling at the injection site, fatigue, muscle pain, headaches, fever, chills, nausea, etc. We considered gender, age, chronic disease, self-assessment of health status, COVID-19 diagnosis, and self-assessment of COVID-19 course as possible predictors of adverse effects. Results: In our sample, 96% developed at least one adverse effect. Half of the participants (50.2%) developed one to five adverse effects, 35.9% developed six to ten adverse effects, and 9.5% developed 11 to 16 adverse effects. Mean number of adverse effects was 5.5. The most frequent adverse effects were pain at the injection site (84.3%), fatigue (70.8%), muscle pain (61%), swelling at the injection site (55.2%), headache (49.8%), fever (42.9%), and chills (41%). Females developed more adverse effects than males (p<0.001). Also, we found a positive relationship between severity of COVID-19 symptoms and adverse effects of COVID-19 vaccines (p=0.005). Moreover, younger age was associated with increased adverse effects (p<0.001). Conclusions: Almost all participants in our study developed minor adverse effects after the booster dose. Female gender, worse clinical course of COVID-19, and decreased age were associated with increased adverse effects. +
++To improve COVID-19 therapy, it is essential to understand the mechanisms driving critical illness. The complement system is an essential part of innate host defense that can also contribute to injury. All complement pathways have been implicated in COVID-19 pathogenesis, however the upstream drivers and downstream consequences on tissue injury remain ill-defined. Here, we demonstrate that complement activation is mediated by the alternative pathway and we provide a comprehensive atlas of the alterations in complement around the time of respiratory deterioration. Proteome and single-cell sequencing mapping across cell types and tissues reveals a division of labor between lung epithelial, stromal and myeloid cells in the production of complement, in addition to liver-derived factors. Upstream, IL-6 drives complement responses, linking complement dysregulation to approved COVID-19 therapies. In an exploratory proteomic study, C5 inhibition improves epithelial damage and markers of disease severity. Collectively, these results identify complement dysregulation as a key druggable feature of COVID-19. +
++Background: COVID-19 waves caused by specific SARS-CoV-2 variants have occurred globally at different times. We focused on Omicron variants to understand the genomic diversity and phylogenetic relatedness of SARS-CoV-2 strains in various regions of Pakistan. Methods: We studied 276,525 COVID-19 cases and 1,041 genomes sequenced from December 2021 to August 2022. Sequences were analyzed and visualized using phylogenetic trees. Results: The highest case numbers and deaths were recorded in Sindh and Punjab, the most populous provinces in Pakistan. Omicron variants comprised 95% of all genomes, with BA.2 (34.2%) and BA.5 (44.6%) predominating. The first Omicron wave was associated with the sequential identification of BA.1 in Sindh, then Islamabad Capital Territory, Punjab, Khyber Pakhtunkhwa (KP), Azad Jammu Kashmir (AJK), Gilgit-Baltistan (GB) and Balochistan. Phylogenetic analysis revealed Sindh to be the source of BA.1 and BA.2 introductions into Punjab and Balochistan during early 2022. BA.4 was first introduced in AJK and BA.5 in Punjab. Most recent common ancestor (MRCA) analysis revealed relatedness between the earliest BA.1 genome from Sindh with Balochistan, AJK, Punjab and ICT, and that of first BA.1 from Punjab with strains from KPK and GB. Conclusions: Phylogenetic analysis provides insights into the introduction and transmission dynamics of the Omicron variant in Pakistan, identifying Sindh as a hotspot for viral dissemination. Such data linked with public health efforts can help limit surges of new infections. +
++Background: Cardiac rehabilitation (CR) is an important tool for improving fitness and quality of life in those with heart disease (HD). Few pediatric centers use CR to care for these patients, and virtual CR is rarely used. Additionally, it is unclear how the COVID-19 era has changed CR outcomes. Objectives: This study assessed fitness improvements in young HD patients participating in both facility-based and virtual CR during the COVID-19 pandemic. Methods: This retrospective single-center cohort study included new patients who completed CR from March 2020 through July 2022. CR outcomes included physical, performance, and psychosocial measures. Comparison between serial testing was performed with a paired t-test with P<0.05 was considered significant. Data are reported as mean±standard deviation. Results: There were 47 patients (19±7.3 years-old; 49% male) who completed CR. Improvements were seen in peak oxygen consumption (VO2, 62.3±16.1 v 71±18.2% of predicted, p=0.0007), 6-minute walk (6MW) distance (401±163.8 v 480.7±119.2 meters, p=<0.0001), sit to stand (16.2±4.9 v 22.1±6.6 repetitions; p=<0.0001), Patient Health Questionnaire-9 (PHQ-9) (5.9±4.3 v 4.4± 4.2; p=0.002), and Physical Component Score (39.9±10.1 v 44.9± 8.8; p=0.002). Facility-based CR enrollees were less likely to complete CR than virtual patients (60%, 33/55 v 80%, 12/15; p=0.005). Increases in peak VO2 (60±15.3 v 70.2±17.8 % of predicted; p=0.002) were seen among those that completed facility-based CR; this was not observed in the virtual group. Both groups demonstrated improvement in 6MW distance, sit-to-stand repetitions, and sit-and-reach distance. Conclusions: Completion of a CR program resulted in fitness improvements during the COVID-19 era regardless of location. +
+Clinical Performance Evaluation of the CareSuperb™ COVID-19 Antigen Home Test - Condition: COVID-19
Intervention: Device: CareSuperb COVID-19 Antigen Home Test Kit
Sponsor: AccessBio, Inc.
Recruiting
Evaluation of Safety & Efficacy of MIR 19 ® Inhalation Solution in Patients With Mild COVID-19 - Condition: COVID-19
Interventions: Drug: MIR 19 ®; Combination Product: Standard therapy
Sponsor: National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
Completed
LACTYFERRIN™ Forte and ZINC Defense™ and Standard of Care (SOC) vs SOC in the Treatment of Non-hospitalized Patients With COVID-19 - Condition: COVID-19
Interventions: Drug: Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™; Drug: Placebo
Sponsors: Jose David Suarez, MD; Sesderma S.L.; Westchester General Hospital Inc. DBA Keralty Hospital Miami; MGM Technology Corp
Not yet recruiting
MP0420 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) - Condition: COVID-19
Interventions: Drug: MP0420; Drug: Placebo; Biological: Remdesivir
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); International Network for Strategic Initiatives in Global HIV Trials (INSIGHT); University of Copenhagen; Medical Research Council; Kirby Institute; Washington D.C. Veterans Affairs Medical Center; AIDS Clinical Trials Group; National Heart, Lung, and Blood Institute (NHLBI); US Department of Veterans Affairs; Prevention and Early Treatment of Acute Lung Injury (PETAL); Cardiothoracic Surgical Trials Network (CTSN); Molecular Partners AG; University of Minnesota
Active, not recruiting
AZD7442 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) - Condition: COVID-19
Interventions: Biological: AZD7442; Biological: Placebo; Biological: Remdesivir
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); International Network for Strategic Initiatives in Global HIV Trials (INSIGHT); University of Copenhagen; Medical Research Council; Kirby Institute; Washington D.C. Veterans Affairs Medical Center; AIDS Clinical Trials Group; National Heart, Lung, and Blood Institute (NHLBI); US Department of Veterans Affairs; Prevention and Early Treatment of Acute Lung Injury (PETAL); Cardiothoracic Surgical Trials Network (CTSN); AstraZeneca; University of Minnesota
Active, not recruiting
VIR-7831 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) - Condition: COVID-19
Interventions: Biological: VIR-7831; Biological: Placebo; Biological: Remdesivir
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); International Network for Strategic Initiatives in Global HIV Trials (INSIGHT); University of Copenhagen; Medical Research Council; Kirby Institute; Washington D.C. Veterans Affairs Medical Center; AIDS Clinical Trials Group; National Heart, Lung, and Blood Institute (NHLBI); US Department of Veterans Affairs; Prevention and Early Treatment of Acute Lung Injury (PETAL); Cardiothoracic Surgical Trials Network (CTSN); Vir Biotechnology, Inc.; GlaxoSmithKline; University of Minnesota
Completed
PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) - Condition: COVID-19
Interventions: Drug: PF-07304814; Drug: Placebo; Biological: Remdesivir
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); International Network for Strategic Initiatives in Global HIV Trials (INSIGHT); University of Copenhagen; Medical Research Council; Kirby Institute; Washington D.C. Veterans Affairs Medical Center; AIDS Clinical Trials Group; National Heart, Lung, and Blood Institute (NHLBI); US Department of Veterans Affairs; Prevention and Early Treatment of Acute Lung Injury (PETAL); Cardiothoracic Surgical Trials Network (CTSN); Pfizer; University of Minnesota
Suspended
BRII-196/BRII-198 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) - Condition: COVID-19
Interventions: Biological: BRII-196; Biological: BRII-198; Biological: Placebo; Biological: Remdesivir
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); International Network for Strategic Initiatives in Global HIV Trials (INSIGHT); University of Copenhagen; Medical Research Council; Kirby Institute; Washington D.C. Veterans Affairs Medical Center; AIDS Clinical Trials Group; National Heart, Lung, and Blood Institute (NHLBI); US Department of Veterans Affairs; Prevention and Early Treatment of Acute Lung Injury (PETAL); Cardiothoracic Surgical Trials Network (CTSN); Brii Biosciences Limited; University of Minnesota
Completed
LY3819253 (LY-CoV555) for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) - Condition: COVID-19
Interventions: Biological: LY3819253; Biological: Placebo; Biological: Remdesivir
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); International Network for Strategic Initiatives in Global HIV Trials (INSIGHT); University of Copenhagen; Medical Research Council; Kirby Institute; Washington D.C. Veterans Affairs Medical Center; AIDS Clinical Trials Group; National Heart, Lung, and Blood Institute (NHLBI); US Department of Veterans Affairs; Prevention and Early Treatment of Acute Lung Injury (PETAL); Cardiothoracic Surgical Trials Network (CTSN); Eli Lilly and Company; University of Minnesota
Completed
Use of E-health Based Exercise Intervention After COVID-19 - Condition: COVID-19
Intervention: Behavioral: Exercise training using an e-health tool
Sponsors: Norwegian University of Science and Technology; University of Oslo
Recruiting
RCT for Yinqiaosan-Maxingganshitang in the Treatment of COVID-19 - Condition: COVID-19
Interventions: Drug: Chinese Herb; Diagnostic Test: Placebo
Sponsor: Chinese University of Hong Kong
Not yet recruiting
A Phase II Clinical Trial of Recombinant Variant COVID-19 Vaccine (Sf9 Cell) (WSK-V102) - Condition: COVID-19
Interventions: Biological: Recombinant variant COVID-19 vaccine (Sf9 cell); Biological: Recombinant COVID-19 vaccine (CHO cell); Biological: Recombinant COVID-19 vaccine (Sf9 cell)
Sponsor: WestVac Biopharma Co., Ltd.
Not yet recruiting
Short-term Effects of Transdermal Estradiol on Female COVID-19 Patients - Conditions: COVID-19; Hormone Replacement Therapy
Interventions: Drug: Climara 0.1Mg/24Hr Transdermal System; Other: Hydrogel patch
Sponsors: Istanbul University - Cerrahpasa (IUC); Turkish Menopause and Osteoporosis Society; Karakoy Rotary Club; Rebul Pharmacy
Completed
Effect of Kinesio Tape Versus Diaphragmatic Breathing Exercise In Post COVID-19 - Condition: Post COVID-19 Condition
Interventions: Other: Pursed lip breathing; Other: Cognitive Behavior Therapy; Other: Diaphragmatic breathing exercise; Other: Kinesio tape
Sponsor: Cairo University
Not yet recruiting
Effect of a Health Pathway for People With Persistent Symptoms Covid-19 - Condition: COVID-19
Interventions: Other: usual care and follow-up by a nurse; Other: Personalized Multifactorial Intervention (IMP)
Sponsor: Centre Hospitalier Universitaire de Saint Etienne
Not yet recruiting
Antiviral activity of curcumin and its analogs selected by an artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells - Curcumin has been reported to exert its anti-SARS-CoV-2 activity by inhibiting the binding of spike receptor-binding domain (RBD) to angiotensin-converting enzyme-2 (ACE2). To identify more potent compounds, we evaluated the antiviral activities of curcumin and its analogs in SARS-CoV-2-infected cells. An artificial intelligence-supported activity prediction system was used to select the compounds, and 116 of the 334 curcumin analogs were proposed to have spike RBD-ACE2 binding inhibitory…
Molecular modeling and simulations of some antiviral drugs, benzylisoquinoline alkaloid, and coumarin molecules to investigate the effects on Mpro main viral protease inhibition - CONCLUSION: In this study, we identify potent molecules that exhibit interactions with catalytical dyad HIS41 and CYS145 amino acids and unravel Coumarin-EM04 exhibited ΔG(bind) higher than Remdesivir against Mpro and thus may serve better antiviral agent against SARS-CoV-2.
Chemical Profiling and Biological Properties of Essential Oils of Lavandula stoechas L. Collected from Three Moroccan Sites: In Vitro and In Silico Investigations - The aim of this study was the determination of the chemical compounds of Lavandula stoechas essential oil from Aknol (LSEO(A)), Khenifra (LSEO(K)), and Beni Mellal (LSEO(B)), and the in vitro investigation of their antibacterial, anticandidal, and antioxidant effects, and in silico anti-SARS-CoV-2 activity. The chemical profile of LSEO was determined using GC-MS-MS analysis, the results of which showed a qualitative and quantitative variation in the chemical composition of volatile compounds…
Recent Developments in Polyphenol Applications on Human Health: A Review with Current Knowledge - Polyphenol has been used in treatment for some health disorders due to their diverse health promoting properties. These compounds can reduce the impacts of oxidation on the human body, prevent the organs and cell structure against deterioration and protect their functional integrity. The health promoting abilities are attributed to their high bioactivity imparting them high antioxidative, antihypertensive, immunomodulatory, antimicrobial, and antiviral activity, as well as anticancer properties….
An Enhanced Dissolving Cyclosporin-A Inhalable Powder Efficiently Reduces SARS-CoV-2 Infection In Vitro - This work illustrates the development of a dry inhalation powder of cyclosporine-A for the prevention of rejection after lung transplantation and for the treatment of COVID-19. The influence of excipients on the spray-dried powder’s critical quality attributes was explored. The best-performing powder in terms of dissolution time and respirability was obtained starting from a concentration of ethanol of 45% (v/v) in the feedstock solution and 20% (w/w) of mannitol. This powder showed a faster…
Phenylpyrazolone-1,2,3-triazole Hybrids as Potent Antiviral Agents with Promising SARS-CoV-2 Main Protease Inhibition Potential - COVID-19 infection is now considered one of the leading causes of human death. As an attempt towards the discovery of novel medications for the COVID-19 pandemic, nineteen novel compounds containing 1,2,3-triazole side chains linked to phenylpyrazolone scaffold and terminal lipophilic aryl parts with prominent substituent functionalities were designed and synthesized via a click reaction based on our previous work. The novel compounds were assessed using an in vitro effect on the growth of…
Cardamonin as a p38 MAPK Signaling Pathway Activator Inhibits Human Coronavirus OC43 Infection in Human Lung Cells - A natural chalcone, cardamonin (2’,4’-dihydroxy-6’-methoxychalcone; CDN) was isolated from the seeds of Alpinia katsumadai Hayata, which has been traditionally used to treat stomach aches. CDN has been reported to possess various pharmacological properties, including anticancer and anti-inflammatory effects. This study evaluated the antiviral activity of CDN against human coronavirus HCoV-OC43 and determined the mode of action in HCoV-OC43-infected human lung cell lines (MRC-5 and A549 cells)….
A Comprehensive Review of Natural Flavonoids with Anti-SARS-CoV-2 Activity - The COVID-19 pandemic caused by SARS-CoV-2 has majorly impacted public health and economies worldwide. Although several effective vaccines and drugs are now used to prevent and treat COVID-19, natural products, especially flavonoids, showed great therapeutic potential early in the pandemic and thus attracted particular attention. Quercetin, baicalein, baicalin, EGCG (epigallocatechin gallate), and luteolin are among the most studied flavonoids in this field. Flavonoids can directly or indirectly…
Unveiling the Inhibitory Potentials of Peptidomimetic Azanitriles and Pyridyl Esters towards SARS-CoV-2 Main Protease: A Molecular Modelling Investigation - The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19, which was declared a global pandemic in March 2020 by the World Health Organization (WHO). Since SARS-CoV-2 main protease plays an essential role in the virus’s life cycle, the design of small drug molecules with lower molecular weight has been a promising development targeting its inhibition. Herein, we evaluated the novel peptidomimetic azatripeptide and azatetrapeptide nitriles against SARS-CoV-2…
Identification of a Synthetic Polyhydroxyphenolic Resveratrol Analogue, 3,3’,4,4’,5,5’-Hexahydroxy-trans-Stilbene with Anti-SARS-CoV-2 Activity - The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has been causing the COVID-19 pandemic since December 2019, with over 600 million infected persons worldwide and over six million deaths. We investigated the anti-viral effects of polyphenolic green tea ingredients and the synthetic resveratrol analogue 3,3’,4,4’,5,5’-hexahydroxy-trans-stilbene (HHS), a compound with antioxidant, antitumor and anti-HIV properties. In the TCID(50) assay, four out of nine green tea constituents…
Identification of Z-Tyr-Ala-CHN2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2 - The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is partly under control by vaccination. However, highly potent and safe antiviral drugs for SARS-CoV-2 are still needed to avoid development of severe COVID-19. We report the discovery of a small molecule, Z-Tyr-Ala-CHN(2), which was identified in a cell-based antiviral screen. The molecule exerts sub-micromolar antiviral activity against SARS-CoV-2, SARS-CoV-1, and human coronavirus 229E….
Green Tea Consumption and the COVID-19 Omicron Pandemic Era: Pharmacology and Epidemiology - In spite of the development of numerous vaccines for the prevention of COVID-19 and the approval of several drugs for its treatment, there is still a great need for effective and inexpensive therapies against this disease. Previously, we showed that green tea and tea catechins interfere with coronavirus replication as well as coronavirus 3CL protease activity, and also showed lower COVID-19 morbidity and mortality in countries with higher green tea consumption. However, it is not clear whether…
The Role of Folic Acid in SARS-CoV-2 Infection: An Intriguing Linkage under Investigation - CONCLUSIONS: Future randomized controlled trial studies, including the FA pharmacological group, are needed to better understand the role of FA as a potential protective or mortality risk indicator in COVID-19 patients.
Prediction and Verification of Curcumin as a Potential Drug for Inhibition of PDCoV Replication in LLC-PK1 Cells - Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus (CoV) that causes lethal watery diarrhea in neonatal pigs and poses economic and public health burdens. Currently, there are no effective antiviral agents against PDCoV. Curcumin is the active ingredient extracted from the rhizome of turmeric, which has a potential pharmacological value because it exhibits antiviral properties against several viruses. Here, we described the antiviral effect of curcumin against…
Direct Application of 3-Maleimido-PROXYL for Proving Hypoalbuminemia in Cases of SARS-CoV-2 Infection: The Potential Diagnostic Method of Determining Albumin Instability and Oxidized Protein Level in Severe COVID-19 - Oxidative stress and the albumin oxidized form can lead to hypoalbuminemia, which is a predisposing factor for reduced treatment effectiveness and an increased mortality rate in severe COVID-19 patients. The aim of the study is to evaluate the application of free radical 3-Maleimido-PROXYL and SDSL-EPR spectroscopy in the in vitro determination of ox/red HSA in serum samples from patients with SARS-CoV-2 infection. Venous blood was collected from patients intubated (pO(2) < 90%) with a positive…
A High-Stakes Election in the Midwest’s “Democracy Desert” - The race for control of Wisconsin’s Supreme Court could change the course of the entire country. - link
Has Benjamin Netanyahu’s Assault on Israeli Democracy Been Stopped? - In the face of mass protests, the Prime Minister has backed down from his plan to overhaul the judiciary—for now. - link
The Horrifying Epidemic of Teen-Age Fentanyl Deaths in a Texas County - Students have overdosed during class, in bathrooms, and in an elementary-school parking lot. - link
Revisiting the Brock Turner Case - In the midst of the #MeToo movement, California voters recalled a judge for being lenient on sexual assault. As a new documentary argues, that recall campaign had unintended results. - link
If Alvin Bragg Indicts Donald Trump, What Will the Case Look Like? - The trial could hinge on the “catch and kill” practices at the National Enquirer. - link
+The underrated way energy efficiency has made life better, and climate progress possible. +
++Consumer tech news tends to focus on the latest gadget like a new smartphone camera, but the boring old refrigerator ought to get its share of credit — when we weren’t looking, the fridge got really good. +
++Since the 1970s, the standard fridge has grown in size, but uses a quarter of the energy of those older models. And you’re getting more for less money, since the manufacturer price of the fridge has halved (adjusting for inflation) in those 50 years. Walk into a Home Depot or Lowes for a replacement, and you can trust that whatever you come out with could be bigger than what you had before, work better than expected, and still not raise your energy bill. +
++It’s not just the refrigerator that’s transformed. Clothes washers and dishwashers have also become more powerful while using less energy and water. LED lights use 75 percent less energy and last 25 times longer than incandescent. And when US energy-related carbon emissions peaked in 2007, one overlooked factor for that peak was better efficiency. +
++All this progress is thanks, in part, to former President Jimmy Carter, who entered hospice at age 98 in late February. While in office, he pioneered many of these gains in US efficiency. +
++From 1977 to 1980, Carter proposed and signed a series of laws that raised the floor for efficiency in the home. One of the most pivotal included creating the Department of Energy, and setting up the appliance standards program that exists today. They cover 65 categories that make up 90 percent of home energy usage, including washing, drying, lighting, refrigeration, heating, cooling, and cooking. +
++Overall, Carter was “the first president to pass a law on energy efficiency standards that had teeth,” says Jay Hakes, a former administrator of the Energy Information Administration and former director of the Jimmy Carter Presidential Library. +
+ ++“The impacts were extraordinary,” Jeff Genzer, an attorney with Duncan, Weinberg, Genzer & Pembroke who has served as counsel to the National Association of State Energy Officials since 1986. “Even though he was in office for only four years, what the advent of appliance standards produced in terms of [lower] energy costs for all consumers in the United States has to be in the hundreds of billions of dollars.” +
++The changes Carter made did more than just make products more efficient. They catalyzed a change in our perception of efficiency — which is still evolving today. The idea of efficiency gradually no longer meant coping with less, but about doing even more with less. Efficiency became a desired feature of the system, a way of improving people’s lives, while giving them more control of the energy system. We don’t get much of a say in which power plant we use, but we do have a say in our appliances. +
++How Americans thought of energy efficiency in the 1970s is, perhaps, best explained by a particular cardigan sweater. +
++In early 1977, the US was still reeling from an oil embargo, in which allied Arab nations blocked oil exports to the US in retaliation for its support for Israel in the 1973 war. The event coincided with gas prices quadrupling that caused a period of stagflation. +
++Carter in response tried to tap into what was left of a post-World War II ethos of political unity and sacrifice for the greater good, explained Hakes. He delivered a series of national speeches framing energy conservation as an unfortunate but necessary sacrifice. Wearing a cardigan in one, he asked Americans to put on their own sweater and lower their thermostats to save energy. He called it “energy conservation.” +
++“Carter, because of that cardigan sweater, made a lot of people think they were going to be freezing in the dark, but that’s not the case at all,” executive director of the American Council for an Energy-Efficient Economy (ACEEE) Steven Nadel said. +
++The unpleasantry of efficiency became a common theme in his speeches. In April 1977 he acknowledged his coming energy proposals would be unpopular because they “will cause you to put up with inconveniences and to make sacrifices.” Some of the proposals included new speed limits for cars (which are more efficient at lower speeds) and an oil profits windfall tax. +
++The parlance of the time was to talk about energy conservation, which was the language Carter used most in his speeches. A sign of its bad reputation was how politicians slowly phased out using the term “conservation” in favor of today’s preferred vocabulary — efficiency. +
++It turns out that the policies that had the most lasting impact were not unpleasant at all. Mandatory standards raised the floor for efficiency, while the extra-efficient technologies get a voluntary Energy Star recognition. +
++Appliance standards require very little sacrifice, even though they took years to finally take hold. The 1978 National Energy Conservation Policy Act enacted Carter’s vision by directing the Department of Energy to set new minimum floors for appliances that were economically and technologically feasible. Ronald Reagan reversed the eight major rules from Carter before they could take effect. But, ultimately, Reagan faced an appeals court reversal forcing him to issue his own standards, which led to a congressional amendment in 1987. The court order found Reagan’s inaction illegal because of the earlier Carter law enacted, explained Nadel. +
++The estimates of how much consumers have saved as a result vary, but are massive by any metric. In 2015, the Department of Energy estimated that it saved households $63 billion in utility bills for that year. Over the decades, though, the benefits have probably accrued to $1 trillion. +
++Carter may be better remembered today for installing solar panels on the White House than his efficiency programs. But his impacts were more pervasive, if hidden from view. “One of the things that the energy efficiency advocates bemoan is the fact that you can see a solar panel, a windmill, and a hydropower facility; you really can’t see energy efficiency,” Genzer said. +
++To be fair, Carter didn’t only frame conservation as sacrifice. He also talked of opportunity. “In fact, it is the most painless and immediate way of rebuilding our nation’s strength,” he said in a landmark 1979 speech. “Every gallon of oil each one of us saves is a new form of production. It gives us more freedom, more confidence, that much more control over our own lives.” +
++This rhetoric, unfortunately, was ahead of its time. Eventually, the US had new technology came along that made it easier to give consumers more options and control, but it was a limiting factor of the time. +
++Clean energy technology was too expensive and difficult to produce to be an easy substitute for fossil fuels. Fuel-switching, or being able to swap a coal plant for gas or renewables, wasn’t a real possibility. So cutting down costs did have to involve some level of using less. +
++The difference today is that the technology has caught up. Electric alternatives to fuel-burning products are relatively easy and low-cost. That includes induction stoves and electric heat pumps and water heaters. These aren’t just more efficient than the gas stove and gas-burning furnace and boiler, but a lot of consumers prefer them because of performance (induction stovetops do not get hot, and heat pump more evenly heats the home compared to gas). +
++Fossil fuel appliances have approached their limit to how efficient they’ll become. The very best furnaces out there are 95 percent efficient, whether they run on gas, oil, or propane, meaning that about 5 percent of the fuel is wasted energy. Heat pumps, in ideal conditions, blow that away, delivering two or three times the heating energy compared to what’s needed to run it. “The heat pump mainly takes the heat out of the air and just needs a little bit of energy to operate those compressors and equipment,” Nadel explained. “And that’s why it’s so much more efficient.” +
++The better technology gives Biden the chance to sell his own climate program as an opportunity that will improve quality of life, while Carter framed his programs as one of sacrifice. In a speech last fall talking about the Inflation Reduction Act and its investments in efficiency upgrades, Biden promised you’re “going to save a lot of money going forward because your utility bills will be lower. And that’s good for your wallet, but it’s also good for the environment because you’re using less energy.” +
++Efficiency now is all about the opportunism. It’s also more critical than ever to meeting climate change goals. As more buildings and cars switch from fossil fuels to electric power, efficiency will be equally important to make sure the grid is actually meeting the strain from rising demand. +
++Since the 1970s we’ve seen an important shift in energy efficiency. First, it was associated with “conservation” or the idea of sacrifice, then morphed into the benefits of saving on one’s energy bill and better technology. We’re shifting into a new era of energy efficiency today, one that is even more ambitious than the iterative progress over refrigerators (which still have room to improve by phasing out planet-warming hydrofluorocarbons). Now, it’s all about remaking buildings. +
++One main area households still have room to improve in energy conservation is their water heating. These are usually a household’s biggest utility expense, and new DOE standards would raise the bar for the lowest-performing appliances. All together, ACEEE counts standards for 47 appliances that are due for upgrades, including for water heating. These would save consumers and businesses a collective $41 billion by 2035. ACEEE estimated these updates also reduce carbon emissions at the equivalent of 13 to 25 coal plants by 2050. +
++The Inflation Reduction Act also changes the field, because it’s the largest federal investment in recent history to improve energy efficiency. The main crux of the law provides incentives and tax breaks to households, businesses, and manufacturers to insulate and weatherize buildings, as well as install technologies like the heat pump. +
++The IRA also starts to address another important, overlooked aspect of efficiency: the building itself. Buildings, not just the products that fill them, can make or break how much energy a household uses. “If you have leaks in your home or if you have really inefficient windows, no matter how efficient your appliances are, you’re still going to be using and wasting a lot of energy,” said Jamal Lewis, director of Policy Partnerships and Equitable Electrification at the advocacy group Rewiring America. +
++Biden’s overall tone is about what we have to gain from efficiency, not lose. And the IRA makes a big bet on efficiency as a politically popular, win-win proposition. “Look, we’re talking about real money here, to save, people,” said Biden. “And it’s just going to start kicking in now.” +
++Biden, like Carter, is using efficiency to help address similar economic challenges and an energy crunch stemming from events beyond US borders. The question is whether the public sees it the same way. The president can raise the bar and set an example. Ultimately, the challenge is not just learning to do more with less, but convincing people that this is a trait worth having in their next furnace, dryer, computer, or stove. +
+Building a longtermism that works for the people of tomorrow — and the people of today. +
++What do you call someone who’s not a longtermist? It might sound like the first half of a joke, but it’s a question that at first glance would seem to lack a satisfactory answer. +
++The proponents of longtermism — an offshoot of effective altruism (EA) — make their case based on three premises: future people matter, there could be a lot of them, and we can make their lives better or worse. This framing is all-encompassing, covering a lot of future, and it sets up what appears to be a dichotomy: if longtermism doesn’t appeal to you, then you must be for present-day people and causes instead. That would make you a “neartermist,” right? (Or more pejoratively, a “short-termist” — unable or unwilling to look beyond the moment — but no one wants to be labeled that.) +
++Within EA, neartermism would describe those who work on causes like disease or poverty in the developing world or ending factory farming, rather than working on efforts to ensure unborn people exist and flourish, such as reducing existential risk, or speeding up technological progress. Outside EA, neartermism would mean showing concern for the big, salient problems of 2023: climate impacts, social inequality, and all the other aching injustices in the world. Not to mention problems in one’s local community, like homelessness or pollution. +
++EA openly embraces the idea that some causes ought to be prioritized, based on factors like importance, neglectedness, and tractability. Building on those foundations, EA longtermists propose that positively influencing the long-term future is a key moral priority of our time — and in its strongest form, it becomes the key moral priority. This apparently zero-sum framing — present needs versus future needs — may go some way to explain why longtermism has attracted so much controversy in recent months (aside from EA’s other more recent scandals: financial, racial, sexual). In the eyes of critics, longtermist philosophy would seem to prioritize the aggregate well-being of 100 trillion-plus hypothetical people in the future over the actual living, breathing 8 billion people alive today. +
++Longtermists counter that the weaker versions of the philosophy are far less demanding, and that a lot of their efforts and spending — on say, reducing existential risk — are good for today and the future. If the world ends, the very real people of the present would be the first to suffer. But taken to an extreme, some critics fear the population ethics underpinning longtermism could lead to a form of mathematical blackmail, a bullet-biting justification for present-day neglect. Worse, that it could lead to real harm through fanatical acts to reduce tiny probabilities of danger sometime in the deep future. In EA parlance, this would be “taking the train all the way to crazy town.” +
++But does caring about the long-term fate of humanity and the planet need to come at the expense of the present? Is choosing one or the other inevitable? I do not believe so. +
++Over the past few years, I’ve been writing a book called The Long View. It’s about the benefits of extending one’s mind into longer-term timescales; not the days, weeks, or months we usually dwell in, but decades, centuries, millennia. Along the way, I’ve crossed paths with various “long-minded” individuals and organizations. I’ve met longtermists, but also those whose timeview is rooted in other values and habits: artists, scientists, anthropologists, historians, writers, Indigenous thinkers and more. (Disclosure: Open Philanthropy provided two career-development grants that supported The Long View, paid directly to the book’s research assistant and international publicist.) +
++Often these long-minded approaches speak different languages, with different priorities and values: some are transcendental and rooted in faith; others are secular and empirical. Some span timescales of centuries; others run to millions of years, many times longer than humans have existed. Some focus purely on humanity; others encompass the natural world too. +
++Encountering all these different perspectives has shown me that taking the long view can and should be plural and democratic. And crucially, they demonstrate that extending one’s circle of concern to tomorrow’s generations needn’t mean prioritizing the future above all. If anything, I’ve discovered that taking a longer view can often lend greater meaning to life in the present: offering perspective and hope amid crisis and difficulty, and a source of energy, autonomy, and guidance when it’s needed. +
++Over the course of writing the book, I’ve learned that I’m not a longtermist. But nor am I a neartermist either. So what are the alternatives? +
++I began to think in earnest about longer-term time just under a decade ago, following a reflection about my daughter’s future. Not long after Grace was born in 2013, I realized something that I had never considered: there are millions of citizens of the 22nd century already living among us. They’re not time-travelers, of course. They are our children. +
++My daughter, to my astonishment, stands a pretty good chance of reaching 2100. She’ll be 86, just a few years more than the average life expectancy for a woman born in the UK. Her children, if she has them, could conceivably reach 2150 if future medicine allows. And, if the average lifespan rises and humanity doesn’t destroy itself, perhaps her grandchildren or great-grandchildren could end up seeing New Year’s Day of the 23rd century. +
++The apparently distant future, I realized, is far nearer and dearer to my own life than I thought. So I better do what I can to ensure it goes well. +
++This reflection about the long-term reach of my potential family ties, and my own ethical responsibilities, led me to the words of the 18th-century writer and politician Edmund Burke. In 1790, he wrote that: +
++++Society is indeed a contract … a partnership not only between those who are living, but between those who are living, those who are dead, and those who are to be born. +
+
+This is an ethical view, centuries before effective altruism was even a notion, that acknowledges that future people matter: a sense of justice, equality, and beneficence toward tomorrow’s generations, built on the awareness of what our forebears did for us. You wouldn’t, however, call it longtermist. +
++Rather than a god-like population-ethics view — adding up the aggregate well-being of people across time within some utilitarian calculation, with the aim of engineering the most good — Burke’s framing emphasizes a partnership, situated in relationships, kin, society, and the connections that link one generation to the next. +
++This sentiment, that we hold a duty to posterity rooted in our generational ties, has come up time after time ever since. For example, in 1866, the British politician John Stuart Mill gave a rousing speech to Parliament about the world we inherit and the world we must leave behind: “It is lent to us, not given: and it is our duty to pass it on, not merely undiminished, but with interest.” In the 20th century, the economist John Maynard Keynes wrote about “economic possibilities for our grandchildren,” hoping for a world of abundant prosperity and leisure time for, well… us (shame that didn’t quite work out). And later, in 1992, the vaccine pioneer Jonas Salk framed our cross-generational obligations with a simple question: “Are we being good ancestors?” +
++A couple of years ago, the writer and researcher Leopold Aschenbrenner — who co-wrote parts of William MacAskill’s longtermist book What We Owe The Future — proposed that longtermism could do more to embrace this approach. “Most of all, I hope that more will take seriously the long arc of time,” he wrote. “Our civilization is an intergenerational enterprise.” He suggested this cross-generational view of ethics might be called “Burkean longtermism.” But if anything, I would argue that longtermism is a modern variant of this long-held if oft-ignored moral principle — not the other way round. +
++Burke himself was not the first to identify the values of stewardship and benevolence toward future generations. Such thinking has emerged within societies and cultures for millennia; perhaps most famously as the Seventh Generation principle, which is thought to go back to the centuries-old Great Law of the Iroquois Confederacy. It’s usually taken to mean making decisions that benefit the next seven generations, but for some Native American scholars, it could also be interpreted as respecting the span of seven generations from your great-grandfather to great-grandchild. +
++Another often-mentioned example is the Maori proverb Ka mua, ka muri, which translates as “walking backward into the future,” emphasizing how the learnings of past generations can provide a guide to what’s ahead. Respect your ancestors, goes the wisdom, and they can help you in return. +
++But there are other non-Western ethical frameworks that deserve to be more widely known. The researcher Cecil Abungu and his team have been collecting examples of long-term thinking in Africa, including Kenya, Nigeria, Ghana, South Africa, and Uganda. He wanted to dispel a myth in 20th-century Western philosophical literature that traditional African communities lacked a conception of the future. “Very many communities did have words to describe the long, long, long-term future, even without knowing that something would definitely happen,” he told me recently. “And lots of communities have proverbs essentially saying that you have to take into account those who will come after you tomorrow.” +
++The project is ongoing, but so far Abungu has identified various examples of spiritual and ethical codes oriented to the future, evidence of the deliberate preservation of artifacts for tomorrow’s generations, as well as principles of land and resource stewardship. +
++One particularly intriguing case study came from the history of the Meru people of Kenya. Every year, he explains, the young men in the group were encouraged to raid the cattle of a neighboring community. It was half-necessary, half-pastime, he said, and while it admittedly involved theft, it was underpinned by an ethical principle oriented toward future people: the men understood that, even as they raided, they should leave some cattle behind. Why? So that the following generation could go raiding too, earning the same status. “It’s not a matter of survival, but more of a matter of flourishing, and living well,” Abungu said. +
++In other words, it was the belief that future people also deserve an opportunity to win praise from their peers and loved ones. +
++Researching my book, I’ve encountered various other communities, campaigners, and nascent movements who strongly believe that future people matter, but wouldn’t describe themselves as either longtermist or neartermist. I’d suggest a better term would simply be “long-minded.” Again, these approaches have roots that go back decades, and they sit outside the world of analytic philosophy. +
++The ocean explorer Jacques Cousteau, for instance, campaigned back in the 1990s for a Bill of Rights for future generations, writing that future people “have a right to an uncontaminated and undamaged Earth and to its enjoyment as the ground of human history, of culture, and of the social bonds that make each generation and individual a member of one human family.” Citizens in the present day, he said, therefore have “a duty as trustee for future generations to prevent irreversible and irreparable harm to life on Earth and to human freedom and dignity.” One supporter, Pierre Chastan, was so inspired that he fashioned a boat out of wood in France, and sailed it to the UN in New York to deliver a barrel of petitions — wearing a Cousteau-style red beanie hat for the trip. +
++Such politically flavored intergenerational justice efforts manifest today as reports like the UN’s 2021 Our Common Agenda, the appointment of a second future generations commissioner in Wales last December, and recent discussion of a future generations bill in the UK House of Lords. Meanwhile, political scientists like Simon Caney at the University of Warwick in the UK have been exploring political reforms and policy proposals, on both a national and global level, that would foster greater rights for future people. +
++Then there are the symbolic long-minded approaches that have emerged in the world of art. One example is the growing community of people around the Scottish artist Katie Paterson’s Future Library in Oslo, Norway. In a forest north of the city, a grove of trees is growing — now about 4 feet tall — that will be used to print a special series of books written for future generations. +
++Every year, an author is invited to write a story that won’t be published until the year 2114. They are kept in a small space in Oslo’s central library called the Silent Room, which was designed to echo the rings of a tree. The first author was Margaret Atwood, who wrote a story called Scribbler Moon. And this May, the Vietnamese American writer and poet Ocean Vuong and German writer and book designer Judith Schalansky will hand over their manuscripts. +
++To do this, the authors are invited to visit the forest for an annual ceremony. When I attended the 2022 handover event, with Zimbabwean author Tsitsi Dangarembga and the Norwegian writer Karl Ove Knausgaard, it was amid 200 to 300 Oslo citizens: people walking their dogs, parents carrying children on their shoulders. They were all participating in a ritual act that encouraged reflection on legacy, art, and what we leave behind. +
++On the surface, there would seem to be a present versus future trade-off with the Future Library: after all, no one can read the books unless they live until 2114, and almost certainly, that won’t include any adult in attendance. But nobody I encountered in the Future Library community — writers, artists, local politicians, and members of the public — seemed to see this as a sacrifice. Rather, the project itself lends a sense of meaning. The act of spending that Sunday morning thinking beyond the salient distractions of the present, and doing so together, provided its own benefits. +
++What might strict longtermists make of all this? Are such approaches and timeviews compatible with the longtermism project, allowing for the pluralism and worldview diversification that some EA leaders have called for, or are they entirely separate? I’m a writer, not a philosopher or an EA, so that’d be for others to weigh in. +
++However, I would be intrigued to see more exploration of what happens when longtermism meets virtue ethics. The long-held moral principle of the duty to posterity is underpinned by what you might call “temporal virtues” — of benevolence, conscientiousness, temperance, and humility for the sake of future people. How these virtues fit (or not) with longtermism is something I’m not qualified to analyze, but I hope someone in that community, or an adjacent one, does. +
++What I can speak to, however, is how the long view has shaped my own personal perspective on the world. Through writing my book, I realized something counterintuitive: that taking the long view allows one to become more present-minded, able to see with far clearer sight what truly matters, what needs to change, what is dangerous and harmful — and what is worth enjoying and appreciating. Reaching for a longer view has provided a source of guidance and solace during some of the best and worst moments in my life: bringing a daughter into the world, and eight years later, losing a baby son. +
++The long view has also provided me with a clarity of purpose in the present, through the call to leave a better world behind for the following generation. Some might interpret that this means building a grand legacy, planning a utopia, or seeking to steer the trajectory of tomorrow. However, I believe any long-minded approach ought to be tempered by humility, democracy, and pluralism. The future, after all, belongs to everyone, and we can’t predict the needs and values of tomorrow’s generations any more than someone living a century ago could imagine all of ours today. +
++Instead, the greatest legacy we can seek to leave behind is choice. If we can ensure that people tomorrow have the ability and autonomy to decide their own path within a sustainable world, then that is enough. For me, that is what long-mindedness means — and it needn’t involve making a choice between whether you care for the near term or the long term. +
++Richard Fisher is the author of The Long View (Wildfire, March 30, 2023). He is an honorary research associate at University College London, and a writer for the website BBC Future. +
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+The debate around which weapons to send to Ukraine, explained. +
++In January, all of Washington seemed rapt with the question of whether the US and Europe would send tanks to Ukraine. +
++Should they? Would they? Why weren’t they? Was it too risky? But also, what was taking so long? Later that month, the US decided to send advanced Abrams tanks and Germany agreed to send Leopards, which cleared the way for other European allies to send military vehicles. +
++A similar dynamic had unfolded around HIMARS missile defense systems that the US sent to Ukraine last year, and it mirrored the protracted debates over lethal aid long before that. Now, it’s playing out again, already, over F-16 fighter jets. +
++I have felt uneasy about these weapons debates. It’s not just the memes of Leopards and Javelin missiles, or the intimacy between the US arms industry and Ukraine. The debate around each new weapon has overshadowed the larger debate about the Ukraine war. +
++The constant shift, that once the Abrams decision was announced Washington moved on to talking about the next advanced system, irked me. Shouldn’t experts, Congress, and the public argue over what the US’s clearly defined interests are in Ukraine and how to achieve them — and how to make sure the war doesn’t drag on and lead to unintended consequences — rather than cheerleading weapons transfers? It seemed to me that the US was going to be debating which weapons systems the US would send to Ukraine every month. +
++But I’ve come to see the fact that there have been debates about each weapons system, with experts openly engaging in these questions in panels and policy papers, to be a good thing. It’s not the only conversation that we should be having, but it serves as a proxy for a serious inquiry into what the US is doing in Ukraine. And, crucially, each tranche of weapons that the US has sent to Ukraine tells us a lot about the Biden administration’s approach to the war at any given time. +
++US President Joe Biden has committed $47 billion of military assistance to Ukraine, and the conversation is ongoing. More debate about arms may lead to more caution and deliberation. +
++In early 2022, or even prior, most experts would tell you that they never would have imagined that the US would send Abrams tanks to Ukraine. Ditto the HIMARS missile defense system. And even the sheer volume of weapons sent to Ukraine exceeds all other US security assistance. +
+ ++But the Biden administration, through an incrementalist approach, has so far charted a careful path. Its support for Ukraine has managed the escalation ladder to avoid nuclear conflict with Russia while keeping European allies largely united in support of Ukraine, ultimately trending toward just an incredible amount of advanced arms for the country. The public debates that have preceded these escalations aren’t just glimpses of that deliberate cautiousness — they’re integral to managing these risks. +
++The primary US interest in this conflict is averting nuclear use and avoiding a direct war between NATO and Russia. Yes, there are other goals: defending sovereignty and international law, as well as signaling to other competitors like China. But avoiding all-out war is an imperative and necessary precondition for that. The decisions to send Ukraine certain classes of weapons speak to this goal, and each decision tells us a lot about how the Biden administration sees the state of the war. +
++Take the recent decision to send tanks. +
++Ukrainian President Volodymyr Zelenskyy had been appealing for tanks since the first months of Russian invasion. Initially, the idea seemed far-fetched and was thought to have dangerous knock-on effects, possibly leading Russian President Vladimir Putin to escalate the war. The US also had concerns that the Ukrainian armed forces wouldn’t be able to use the equipment effectively and that it would take at least a year to deliver them. Throughout the fall, Zelenskyy renewed calls for them in the US media and during his Washington visit pleaded for them directly to the White House. +
++By January, Chancellor Olaf Scholz had reportedly said behind closed doors that Germany would send Ukraine its easier-to-operate Leopard tanks — only if the US would send Abrams. +
++But the US Defense Department’s policy leader, Colin Kahl, said that Abrams’ complex jet engine made it a no-go. “I just don’t think we’re there yet,” he said upon returning from a visit to Kyiv. The Pentagon also suggested that the tanks wouldn’t make a huge difference for Ukraine on the battlefield. +
++After a rather public discussion about whether the US would send tanks over, the Biden administration changed its position, which led the way to Germany sending Leopard tanks. There was excitement in some quarters of Washington. The head of the usually dispassionate Brookings Institution’s Europe program, Constanze Stelzenmüller, called it “tanksgiving” and tweeted that she would wear leopard print to celebrate. +
++On March 21, the Pentagon announced a sped-up timeline for their delivery. +
++Some of this is about symbolism and the image of the US sending its most advanced systems to Ukraine. And some of it is very particularly about how it would shape Ukraine’s defense and prospective counter-offensive likely to unfold in the coming weeks. +
++Staunch backers of Ukraine resented that it was even a discussion at all. Former military leaders and national security leaders have been pushing for a ramp-up of sending or producing more weapons, like long-range missiles, ASAP. The ideas vary, but generally argue that Ukraine needs the weapons to defeat Russia now to avoid a damaging protracted conflict. And that by taking an incremental approach or not providing the country with weapons like the F-16s urgently, Russia may gain an advantage. +
++The success of the Biden administration’s relative cautiousness has led some more hawkish experts to invert the chain of events, and argue that the lack of Russian nuclear escalation signals that the US can send anything it wants to Ukraine without risking inadvertent expansion of the conflict. +
++But Russia still may escalate, says Miranda Priebe, a political scientist at the Rand Corporation. “It’s the wrong lesson to take from what has happened so far that there are no limits,” she told me. “Nuclear escalation isn’t the only thing I worry about. Russia still has a lot of cards to play.” Those may include increased strikes on civilians and Ukrainian infrastructure, or massive cyber attacks. +
++The US also needs to think about the sustainability of its involvement. Jeremy Shapiro, research director at the European Council on Foreign Relations, says the Biden administration is making good decisions about what to send at each phase of the war. But there are still dangers of a quagmire. +
++“They’re creating a situation for themselves where they’re inexorably getting drawn in more and more, and that’s why they’re in a place right now that they didn’t want to be 12 months ago,” he says, “which is supplying weapons which are frighteningly escalatory and even more importantly, facing a weapons-supply future that will be extremely difficult to satisfy, and will drain them of the capacity to promote other priorities, such as Asia-Pacific.” +
++As yet, the Biden administration’s calibrated approach has worked, and it’s forced them to explain to the public what these weapons do and why they matter. +
++“What I would like the US debate about weapons systems to be is focused on what we’re trying to achieve in the war,” Shapiro, who served in the Obama State Department, told me. “We have to define our own interests, which will be distinct although overlapping with the Ukrainians, and then we have to tailor the weapons systems to what our goals are.” +
++An enduring question is whether the Biden administration is fully in control of the sliding-scale dynamic, because as soon as there’s a big-deal announcement that the US will send a new advanced weapons system, immediately the debate shifts to the next one, and the next one. +
++When the White House convened one of its regular private Zoom calls with policy experts from outside of government on January 25, many participants applauded the administration for its tank moves. These background briefings for think-tankers have been described as cheerleading sessions. +
++But, a familiar voice said that the tanks were not enough, according to three attendees who asked to remain anonymous. Alexander Vindman, the retired lieutenant colonel who served as a Trump White House official and was a star of former president’s first impeachment trial, has been a vocal proponent of arming Ukraine to the max. On the January White House call, he asked about what more the US could do for Ukraine. +
++“They wanted a pat on the back. And, you know, I gave them that,” Vindman told me. But he calls the Biden administration’s caution “reactive” and “non-strategic,” explaining that getting Ukraine air defense systems and fighter jets quickly would hasten Russia’s defeat and thus the war’s end. +
++“It’s not that it’s been deliberative, it’s been plodding,” he said. “We’re going to eventually provide these long-range systems, it’s a matter of when. Ukraine is going to get jets, too. It’s a matter of when.” +
++It’s true that much of Ukraine’s battlefield success is dependent on Western military assistance. But there are a lot of other debates and strategic concerns that need to be as prominent as the weapons question. +
++“I think we too quickly jump to: Should we give them ATACMS, F-16s? What’s the next move?” Charles Kupchan, a former adviser to then-Vice President Biden, recently told the Council on Foreign Relations. “And I think one of the key challenges we face moving forward is keeping American interest in sync with the nature of our commitment.” +
++Maybe the weapons questions can get us there. +
++A year into this conflict, with Republican members of Congress, former President Donald Trump, and Florida Governor Ron DeSantis questioning the Biden administration’s policy, it may lead to a more serious conversation about the issues at stake. Republicans are forcing Biden to more clearly articulate the importance of Ukraine to the United States. +
++It’s not yet clear whether the US or Ukraine would accept a situation in which Ukraine regains much of the territory it had lost since Russia’s invasion started on February 24, 2022, but not the peninsula in the country’s south, Crimea, which Russia has occupied since 2014. “The main issue here to debate, which I think the weapons question deflects from, is what we are satisfied with in terms of Ukraine regaining territory,” says Stephen Wertheim of the Carnegie Endowment for International Peace. +
++At the same time, there’s a drumbeat for Ukraine to get some form of Western security guarantees that might ultimately include membership in NATO. That deserves as much consideration as the weapons debate. +
++As we look back two decades later at the feverish support for the US invasion of Iraq and its current devastating impact on the Middle East, the perils of groupthink are on display. We must make space for dissenters. And we may be entering a moment where weapons provisions become so normalized that the US ends up invariably playing a role in ratcheting tensions up further and further without the sort of cautious deliberation that the Biden administration has expressed so far. +
++Through specific weapons, the Biden administration is showing an increasing commitment to Ukraine. Still, attendees on the White House call in January told me that the White House pushed back against Ukraine’s biggest boosters. It goes to show how US and Ukrainian interests are not identical. There does not seem to be consideration, for example, of giving nuclear weapons to Ukraine. +
++For now, the sometimes tiresome debates around weapons serve as a proxy for a bigger conversation, one that may ultimately serve to inform Americans about the risks and realities of war. +
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Power demand peaks as temperature rises in State -
Here are the big stories from Tamil Nadu today - Welcome to the Tamil Nadu Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Lalitha Ranjani.
Spectator killed in bull race near Jolarpet - The bull charged towards the crowd and attacked 17-year-old Vikram, a school drop-out
Why can’t Modi be disqualified, asks Abhishek Banerjee - “I may not support Gandhi’s comment but I condemn the way he was disqualified from the Lok Sabha.”
Italy moves to ban lab-grown meat to protect food heritage - Prime Minister Giorgia Meloni says the proposed ban aims to protect farmers and consumers.
Amsterdam launches stay away ad campaign targeting young British men - The Dutch city targets UK men aged 18-35 in an ad campaign aimed at changing its reputation.
Swiss court case ties human rights to climate change - Thousands of women say the country’s climate change policy damages their right to life and health.
King Charles’s first state visit: What to expect from Germany trip - Improving relations with Europe is the priority, as the King’s first state visit heads for Germany.
New cars sold in EU must be zero-emission from 2035 - The deal was delayed for weeks after Germany called for an exemption for cars running on e-fuels.
With Amazon Alexa’s future in peril, Fire TVs offer a glimmer of hope - Fire TV devices encourage the kind of Alexa interactions that actually make money. - link
Ransomware crooks are exploiting IBM file-exchange bug with a 9.8 severity - If you haven’t patched your Aspera Faspex server, now would be an excellent time. - link
Apple Pay Later turns Apple into a full-on money lender - Financial product launches nearly a year after it was first announced. - link
Healthy adults don’t need annual COVID boosters, WHO advisors say - The advice clashes with FDA’s suggestion to treat COVID boosters like flu shots. - link
Huawei’s foldable is thinner, lighter, and has more battery than Samsung - Huawei can’t use 5G, Gorilla Glass, or the Google apps, but it’s managing. - link
What’s the opposite of “Debbie Downer”? -
++Beth-amphetamine +
++Edit: Geez, tough crowd. +
+ submitted by /u/Spiritual_Bet_7604
[link] [comments]
A chicken farmer went to a local bar, sat next to a woman and ordered a glass of champagne. -
++The woman perked up and said, “How about that? I just ordered a glass of champagne, too!” +
++“What a coincidence,” the farmer said. “This is a special day for me; I am celebrating.” +
++“This is a special day for me too, I am also celebrating,” said the woman. +
++“What a coincidence!” said the farmer. As they clinked glasses, he added, “What are you celebrating?” +
++“My husband and I have been trying to have a child, and today my gynecologist told me that I am pregnant!” +
++“What a coincidence!” said the man. “I’m a chicken farmer, and for years all of my hens were infertile, but today they are all laying fertilized eggs.” +
++“That’s great!” said the woman, “How did your chickens become fertile?” +
++“I used a different rooster,” he replied. +
++The woman smiled, clinked his glass and said, “What a coincidence!” +
+ submitted by /u/orgasmic2021
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Did you know that too much sex can cause memory loss? -
++I read that in a medical journal on page 64, at 2:34pm on Friday 15th of August, 2021. +
+ submitted by /u/Motasim09
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I wish this was a joke -
++So I’m a primary care physician and last week we did away with mandatory masking. +
++Today one of my young female front office girls approached me and said “People are so much nicer to me when I tell them they don’t have to mask anymore!” +
++I said “Thats great!” +
++She said “yeah, it’s like when I tell a guy he doesn’t need to use a condom!” +
++I’m speechless. +
+ submitted by /u/LookingOutForU
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Why is there no pregnant Barbie doll? -
++Because Ken came in another box. +
+ submitted by /u/travels_the_world
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