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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Evaluation of long-term sequelae by cardiopulmonary exercise testing 12 months after hospitalization for critical COVID-19</strong> -
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Background: Cardiopulmonary exercise testing (CPET) is an important clinical tool that provides a global assessment of the respiratory, circulatory and metabolic responses to exercise which are not adequately reflected through the measurement of individual organ system function at rest. In the context of critical COVID-19, CPET is an ideal approach for assessing long term sequalae. Methods: In this prospective single-center study, we performed CPET in 60 patients, 12 months after a critical COVID-19 infection that required intensive care unit (ICU) treatment. Lung function at rest and chest computed tomography (CT) scan were also performed. Results: Twelve months after severe COVID-19 pneumonia, the majority of the patients had a peak O2 uptake (VO2) considered within normal limits. However, length of ICU stay remained an independent predictor of VO2. Surprisingly, more than half of the patients with a normal peak predicted VO2 showed ventilatory inefficiency during exercise (high VE/VCO2 ratio and high VE/VCO2 slope) with increased physiological dead space (VD/Vt) and low end-tidal CO2 partial pressure (PETCO2) values. This impairment was even more pronounced in patients with persistent dyspnea. Notably, peak VD/Vt values were positively correlated with peak D-Dimer plasma concentrations from blood samples collected during ICU stay. Conclusions: Even if reduced exercise capacity was rare 12 months after critical COVID-19, more than half of the patients with normal exercise capacity showed ventilatory inefficiency.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.12.22279779v1" target="_blank">Evaluation of long-term sequelae by cardiopulmonary exercise testing 12 months after hospitalization for critical COVID-19</a>
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<li><strong>A Cross-Sectional Study of Quantitative CT Measurements Associated with the Diffusion Capacity of the Lung in Recovered COVID-19 Patients with Clear Chest CTs</strong> -
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Impairment of the diffusion capacity of the lung for carbon monoxide (DLco) is commonly reported in convalescent and recovered COVID-19 patients, although the cause is not fully understood especially in patients with no radiological sequelae. In a group of 47 patients at 7 - 51 weeks post infection with either none or minimal scarring or atelectasis on chest CT scans (total &lt; 0.1% of lung volume), dispersions in DLco-adj % and total lung capacity (TLC) % of predicted were observed, with median(quartiles) of 87(78, 99)% and 84(78, 92)%, respectively. Thirteen(27.1%) patients had DLco-adj% &lt; 80%. Although the DLco-adj% did not significantly correlate with the severity of the illness in the acute phase, time since the onset of symptoms, the volume of residual lesions on CT, age or sex, DLco-adj/alveolar volume (Kco-adj) % predicted was correlated with the measurements of small blood vessel volume fraction (diameter &lt;= 5mm) and parenchyma density on CT. Multivariate analysis revealed that these two CT metrics significantly contributed to the variance in DLco-adj% independent of TLC%. Comparing to between-subject variability of DLco-adj in healthy individuals, patients in this cohort with DLco-adj% &lt; 80% were likely abnormal with a degree of disease not visually detectable on CT. However, it is not clear whether the associated variance of parenchyma density and small-vessel volume fraction were a consequence of the COVID-19 disease or a pre-existing background variance.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.13.22279543v1" target="_blank">A Cross-Sectional Study of Quantitative CT Measurements Associated with the Diffusion Capacity of the Lung in Recovered COVID-19 Patients with Clear Chest CTs</a>
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<li><strong>What is the effectiveness of financial support schemes for individuals requested to self-isolate following a positive Covid test or positive contact: A rapid review</strong> -
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Testing for COVID-19 has been deployed globally as a tool to interrupt transmission through isolating positive contacts from the broader population. Financial support systems have been deployed to increase the isolation compliance, there is uncertainty as to the effectiveness of these measures. Three reviews were identified, as well as four primary studies that were published after the review search dates. Six studies showed that financial support for isolation was associated with a higher compliance to isolate. Two epidemiological modelling studies found that increased levels of social isolation were associated with a reduction in COVID-19 transmission. The findings from a DCE demonstrated a positive relationship with longer isolation duration and higher financial requirements. An economic model showed that support programmes have the potential to be a cost-effective intervention. A retrospective observational study offered evidence supporting the viability of delivering medically assisted isolation hotels for people unable to isolate at home. Further to the COVID-19 literature, two household surveys found that financial support and improved social restriction information was associated with compliance with H1N1 isolation Policy and practice implications: There is limited evidence to suggest that financial support for isolation can increase compliance, lower social engagement, and reduce infection levels. There is insufficient evidence to inform the optimal scale of financial support required There was no evidence related to effectiveness of financial support for disadvantaged populations who are required to isolate or any insight to the impact of financial support on equality The overall certainty in the evidence is relatively low. Most studies relied on participant reported data on preference or behaviour, and where observational data were used there were issues with data quality and unobserved cofounders.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.15.22279969v1" target="_blank">What is the effectiveness of financial support schemes for individuals requested to self-isolate following a positive Covid test or positive contact: A rapid review</a>
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<li><strong>O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Contribute to the Mutational Trajectory in Variants of Concern</strong> -
<div>
The emergence of a polybasic cleavage motif for the protease furin in the SARS-CoV-2 spike protein has been established as a major factor for enhanced viral transmission in humans. The peptide region N-terminal to that motif is extensively mutated in major variants of concern including alpha, delta and omicron. Besides furin, spike proteins from these variants appear to rely on other proteases for maturation including TMPRSS2 that may share the same cleavage motif. Glycans found near the cleavage motif have raised questions about proteolytic processing and the consequences of variant-borne mutations. Here, with a suite of chemical tools, we establish O-linked glycosylation as a major determinant of SARS-CoV-2 spike cleavage by the host proteases furin and TMPRSS2 and a likely driving force for the emergence of common mutations in variants such as omicron, delta and alpha. We provide direct evidence that the glycosyltransferase GalNAc-T1 primes glycosylation at Thr678 in the living cell. A novel strategy for rapid bioorthogonal modification of Thr678-containing glycopeptides reveals that introduction of a negative charge completely abrogates furin activity. In a panel of synthetic glycopeptides containing elaborated O-glycans, we find that sialic acid moieties reduce furin cleavage rate by up to 65%. Similarly, O-glycosylation had a general negative impact on spike cleavage by TMPRSS2, with core 1 (Gal{beta}1-3GalNAc-) O-glycan-containing glycopeptides having the largest effect. With a chemistry-centered approach, we thus firmly establish O-glycosylation as a major determinant of spike maturation. We propose that a disruption of O-GalNAc glycosylation is a substantial driving force for the evolution of variants of concern.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.15.508093v1" target="_blank">O-Linked Sialoglycans Modulate the Proteolysis of SARS-CoV-2 Spike and Contribute to the Mutational Trajectory in Variants of Concern</a>
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<li><strong>A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2</strong> -
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The ongoing pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA recognition and druggability of the nucleocapsid N-protein of SARS-CoV-2, a highly abundant protein crucial for the viral life cycle. We use a synergistic method that combines NMR spectroscopy and protein-RNA cross-linking coupled to mass spectrometry to quickly determine the RNA binding of two RNA recognition domains of the N-protein. Finally, we explore the druggability of these domains by performing an NMR fragment screening. This workflow identified small molecule chemotypes that bind to RNA binding interfaces and that have promising properties for further drug development.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.15.507991v1" target="_blank">A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2</a>
</div></li>
<li><strong>Fast bioluminescent nucleic acid detection using one-pot isothermal amplification and dCas9-based split luciferase complementation</strong> -
<div>
Nucleic acid detection methods based on isothermal amplification techniques show great potential for point-of-care diagnostic applications. However, most current methods rely on fluorescent or lateral flow assay readout, requiring external excitation or post-amplification reaction transfer. Here, we developed a bioluminescent nucleic acid sensor (LUNAS) platform in which target dsDNA is sequence-specifically detected by a pair of dCas9-based probes mediating split NanoLuc luciferase complementation. Whereas LUNAS itself features a detection limit of ~1 pM for dsDNA targets, the LUNAS platform is easily integrated with recombinase polymerase amplification (RPA), providing attomolar sensitivity in a single-pot assay. We designed a one-pot RT-RPA-LUNAS assay for detecting SARS-CoV-2 RNA without the need for RNA isolation and demonstrated the diagnostic performance for COVID-19 patient nasopharyngeal swab samples using a digital camera to record the ratiometric signal. Detection of SARS-CoV-2 from samples with viral RNA loads of ~200 cp/microL was achieved within ~20 minutes, showing that RPA-LUNAS is attractive for point-of-care diagnostic applications.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.12.507659v1" target="_blank">Fast bioluminescent nucleic acid detection using one-pot isothermal amplification and dCas9-based split luciferase complementation</a>
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<li><strong>Cognitive status and rehabilitation outcomes of patients in acute rehabilitation post Covid-19</strong> -
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Objective: This study aims to 1) characterize cognitive functioning in patients admitted for inpatient rehabilitation due to Covid-19 diagnosis and 2) examine how cognitive status at admission is associated with rehabilitation outcomes. Design: Retrospective chart review. Setting: An inpatient rehabilitation center located in Chicago, Illinois. Participants: 80 participants in acute rehabilitation due to Covid-19 disease/ Intervention: Not applicable. Main Outcome Measures: Cognitive functioning as measured by the Montreal Cognitive Assessment (MoCA) and rehabilitation outcomes as measured by Functional Index Measure (FIM) and Section GG items for self-care and mobility (GG-SC and GG-M respectively). Results: On average, our sample presented with mild cognitive impairment as assessed by the (MoCA). The most significant deficits were demonstrated in executive function, attention, language, and delayed free recall measures. Higher levels of overall cognitive function were associated with higher cognitive measures of rehabilitation outcomes. Weaker associations were observed with outcome measures of self-care and motor functioning. Conclusion: Cognitive impairments are common in patients in acute rehabilitation due to Covid-19 and cognitive performance may help predict rehabilitation outcomes.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.10.22279806v1" target="_blank">Cognitive status and rehabilitation outcomes of patients in acute rehabilitation post Covid-19</a>
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<li><strong>Antigen concentration, viral load, and test performance for SARS-CoV-2 in multiple specimen types</strong> -
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The relationship between N-antigen concentration and viral load within a specimen and across different specimens is essential for interpretation of rapid diagnostic tests (RDT) clinical performance in different use cases. A prospective study was conducted in Porto Velho, Brazil, to investigate RDT performance in different specimen types as a function of the correlation between antigen concentration and viral load. The study included 214 close contacts with recent exposures to confirmed cases, aged 12 years and older and with various levels of vaccination. Antigen concentration was measured in nasopharyngeal swab (NPS), anterior nares swab (ANS), and saliva specimens. Reverse transcriptase (RT)PCR was conducted on the NPS and saliva specimens, and two RDTs were conducted on ANS and one on saliva. Antigen concentration correlated with viral load when measured in the same specimen type but not across specimen types. Antigen levels were higher in symptomatic cases compared to asymptomatic/oligosymptomatic cases and lower in saliva compared to NPS and ANS samples. Discordant results between the RDTs conducted on ANS and the RT-PCR on NPS were resolved by antigen concentration values. The analytical limit-of-detection of RDTs can be used to predict the performance of the tests in populations for which the antigen concentration is known. The antigen dynamics across different sample types observed in SARS-CoV-2 disease progression support use of RDTs in nasal samples. Given lower antigen concentrations in saliva, tests using saliva is expected to require improved analytical sensitivity to achieve clinical sensitivity similar to testing of nasal samples.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.12.22279810v1" target="_blank">Antigen concentration, viral load, and test performance for SARS-CoV-2 in multiple specimen types</a>
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<li><strong>COVID-19 induced birth sex ratio changes in England and Wales</strong> -
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Background The sex ratio at birth (male live births divided by total live births) may be a sentinel health indicator. Stressful events reduce this ratio 3-5 months later by increasing male fetal loss. This ratio can also change 9 months after major population events that are linked to an increase or decrease in the frequency of sexual intercourse at the population level, with the ratio either rising or falling respectively after the event. We postulated that stress caused by the COVID-19 pandemic may have affected the ratio in England and Wales. Methods Publicly available, monthly live birth data for England and Wales was obtained from the Office for National Statistics up to December 2020. The sex ratio at birth for 2020 (global COVID-19 onset) was predicted using data from 2012-2019. Observed and predicted values were compared. Results Three months after COVID-19 was declared pandemic (March 2020), there was a significant fall in the sex ratio at birth to 0.5100 in June 2020 which was below the 95% prediction interval of 0.5102-0.5179. Nine months after the pandemic declaration, (December 2020), there was a significant rise to 0.5171 (95% prediction interval 0.5085-0.5162). However, December 2020 had the lowest number of live births of any month from 2012 to 2020. Conclusions Given that June 2020 falls within the crucial window when population stressors are known to affect the sex ratio at birth, these findings imply that the start of the COVID-19 pandemic caused population stress with notable effects on those who were already pregnant by causing a disproportionate loss of male fetuses. The finding of a higher sex ratio at birth in December 2020, i.e., 9 months after COVID-19 was declared a pandemic, suggests that lockdown restrictions initially spurred more sexual activity in a subset of the population in March 2020.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.09.22279763v1" target="_blank">COVID-19 induced birth sex ratio changes in England and Wales</a>
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<li><strong>Detecting changes in population trends in infection surveillance using community SARS-CoV-2 prevalence as an exemplar</strong> -
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Background: Monitoring infection trends is vital to informing public health strategy. Detecting and quantifying changes in growth rates can inform policymakers9 rationale for implementing or continuing interventions aimed at reducing impact. Substantial changes in SARS-CoV-2 prevalence with emergence of variants provides opportunity to investigate different methods to do this. Methods: We included PCR results from all participants in the UK9s COVID-19 Infection Survey between 1 August 2020-30 June 2022. Change-points for growth rates were identified using iterative sequential regression (ISR) and second derivatives of generalised additive models (GAMs). Consistency between methods and timeliness of detection were compared. Findings: Of 8,799,079 visits, 147,278 (1.7%) were PCR-positive. Over the time period, change-points associated with emergence of major variants were estimated to occur a median 4 days earlier (IQR 0-8) in GAMs versus ISR, with only 2/48 change-points identified by only one method. Estimating recent change-points using successive data periods, four change-points (4/96) identified by GAMs were not found when adding later data or by ISR; 77% (74/96) of change-points identified by successive GAMs were identified by ISR. Change-points were detected 3-5 weeks after they occurred in both methods but could be detected earlier within specific subgroups. Interpretation: Change-points in growth rates of SARS-CoV-2 can be detected in near real-time using ISR and second derivatives of GAMs. To increase certainty about changes in epidemic trajectories both methods could be run in parallel. Running either method in near real-time on different infection surveillance data streams could provide timely warnings of changing underlying epidemiology. Funding: UK Health Security Agency, Department of Health and Social Care (UK), Welsh Government, Department of Health (on behalf of the Northern Ireland Government), Scottish Government, National Institute for Health Research.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.14.22279931v1" target="_blank">Detecting changes in population trends in infection surveillance using community SARS-CoV-2 prevalence as an exemplar</a>
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<li><strong>Real-time intelligent classification of COVID-19 and thrombosis via massive image-based analysis of platelet aggregates</strong> -
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Microvascular thrombosis is a typical symptom of COVID-19 and shows similarities to thrombosis. Using a microfluidic imaging flow cytometer, we measured the blood of 181 COVID-19 samples and 101 non-COVID-19 thrombosis samples, resulting in a total of 6.3 million bright-field images. We trained a convolutional neural network to distinguish single platelets, platelet aggregates, and white blood cells and performed classical image analysis for each subpopulation individually. Based on derived single-cell features for each population, we trained machine learning models for classification between COVID-19 and non-COVID-19 thrombosis, resulting in a patient testing accuracy of 75%. This result indicates that platelet formation differs between COVID-19 and non-COVID-19 thrombosis. All analysis steps were optimized for efficiency and implemented in an easy-to-use plugin for the image viewer napari, allowing the entire analysis to be performed within seconds on mid-range computers, which could be used for real-time diagnosis.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.13.22279890v1" target="_blank">Real-time intelligent classification of COVID-19 and thrombosis via massive image-based analysis of platelet aggregates</a>
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<li><strong>Real-world Use of Nirmatrelvir-Ritonavir in COVID-19 Outpatients During the Emergence of Omicron Variants BA.2/BA2.12.1</strong> -
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Background: Ritonavir-boosted Nirmatrelvir (NMV-r), a protease inhibitor with in vitro activity against SARS-CoV-2, has been shown to reduce risk of progression to severe COVID-19 among high-risk individuals during the Delta-variant phase. We sought to determine the effectiveness of NMV-r against Omicron lineage variants BA.2/BA2.12.1, and assess for evidence of a clinical rebound effect. Methods: We conducted a retrospective observational cohort study of non-hospitalized adult patients with SARS-CoV-2 infection from March 26th, 2022 to June 23rd, 2022, using records from a statewide health system linked to vaccine and mortality data. Propensity score matching was performed on NMV-r treated outpatients with outpatients not treated with antiviral therapy. The primary outcome was 28-day all-cause hospitalization; secondary outcomes were COVID-19-related hospitalization, 28-day all-cause mortality, and 28-day ED visits. Logistic regression was used to determine NMV-r treatment effectiveness; subgroup analyses were performed to assess for heterogeneity in treatment effect. Results: Of 14,953 SARS-CoV-2 infected outpatients, 3,614 NMV-r treated patients were matched to 4,835 untreated outpatients. NMV-r was associated with significantly lower odds of 28-day all-cause hospitalization as compared to no antiviral treatment [31 (0.9%) vs. 64 (1.3%), adjusted odds ratio (aOR): 0.48 (95% CI 0.31-0.75)]. NMV-r was also associated with lower odds of COVID-19 related hospitalization [aOR (95% CI): 0.42 (0.25-0.68)] and 28-day all-cause mortality [aOR (95% CI): 0.05 (0.00-0.38)]. Using ED visits within 28 days as a surrogate for rebound symptoms, we observed no clinically evident rebound effect with NMV-r treatment [140 (3.9%) vs 205 (4.2%), aOR: 0.81 (95% CI 0.65-1.02), p = 0.075]. Conclusion: Real-world evidence during an Omicron BA.2/BA2.12.1 predominant period demonstrated an association of NMV-r treatment with reduced 28-day hospitalization and all-cause mortality, and without an increase in rebound symptoms as assessed by ED visits within 28 days after treatment.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.12.22279866v1" target="_blank">Real-world Use of Nirmatrelvir-Ritonavir in COVID-19 Outpatients During the Emergence of Omicron Variants BA.2/BA2.12.1</a>
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<li><strong>Angiotensin 1-7 in severe COVID-19 patients: a phase 1 clinical trial</strong> -
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Background: The coronavirus-related disease (COVID-19) is mainly characterized by a respiratory involvement, with few available therapeutics for critically cases. The renin-angiotensin system (RAS) has a relevant role in the pathogenesis of COVID-19, as the virus enter host9s cells via the angiotensin-converting enzyme 2 (ACE2) and RAS disequilibrium promote inflammation and fibrosis. Exogenous angiotensin-(1-7) might modulate RAS in COVID-19 patients; however, no data on its safety are available in this setting. Methods: This investigator-initiated, open label, phase I clinical trial was conducted to test the safety of intravenous administration of Angiotensin-(1-7) in severe COVID-19 patients admitted in two intensive care units (ICU) in Belo Horizonte, Brazil. In addition to standard of care, intravenous administration of Angiotensin-(1-7) was started at 5 mcg/Kg<em>day and increased to 10 mcg/Kg</em>day after 24 hours and continued for a maximum of 7 days or until ICU discharge. The rate of serious adverse events (SAEs) served as the primary outcome of the study. Results: Between August and December 2020, 28 patients were included (mean age of 55.8 + or -12.0 years). All but one patient underwent dose escalation after 24 hours and 8 (28.5%) received the treatment until day 7. No significant differences in mean blood pressure and heart rate were observed before and after the initiation of the drug. During the period of intervention, 5/28 (17.8%) patients required vasopressors, 4 at low dose norepinephrine (i.e. &lt;0.05 mcg/kg<em>min), while one patient required higher doses because of septic shock. One patient presented with sinus bradycardia, which was considered possibly related to the study drug and resolved after discontinuation. Six patients (21.4%) died before ICU discharge. Conclusions: Intravenous infusion of Angiotensin-(1-7) up to 10 mcg/Kg</em>day was safe in severe COVID-19 patients and could represent a potential therapeutic strategy in this setting.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.15.22279897v1" target="_blank">Angiotensin 1-7 in severe COVID-19 patients: a phase 1 clinical trial</a>
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<li><strong>Humoral and Cellular Immunogenicity and Safety of 3 Doses of CoronaVac and BNT162b2 in Young Children and Adolescents with Kidney Diseases</strong> -
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Background: Patients with kidney diseases are at risk of severe complications from COVID-19, yet little is known about the effectiveness of COVID-19 vaccines in children and adolescents with kidney diseases. Methods: We investigated the immunogenicity and safety of an accelerated, 3-dose primary series of COVID-19 vaccines among 64 pediatric chronic kidney disease patients (mean age 12.2; 32 male) with or without immunosuppression, dialysis, or kidney transplant. CoronaVac was given to those aged &lt;5 years, 0.1ml BNT162b2 to those aged 5-11 years, and 0.3ml BNT162b2 to those aged 11-18 years. Results: Antibody responses including S-RBD IgG (90.9-100% seropositive) and surrogate virus neutralization (geometric mean sVNT% level, 78.6-94.0%) were significantly elicited by 3 doses of any vaccine. T cell responses were also elicited. Weaker neutralization responses were observed among kidney transplant recipients and non-dialysis children receiving rituximab for glomerular diseases. Neutralization was reduced against Omicron BA.1 compared to wild-type (post-dose 3 sVNT% level; 84% vs 27.2%; p&lt;0.0001). However, T cell response against Omicron BA.1 was preserved, which likely confer protection against severe COVID-19. Hybrid immunity was observed after vaccination in infected patients, as evidenced by higher Omicron BA.1 neutralization response among infected patients receiving 2 doses than those uninfected. Generally mild or moderate adverse reactions following vaccines were reported. Conclusions: Our findings support that an accelerated 3-dose primary series with CoronaVac and BNT162b2 is safe and immunogenic in young children and adolescents with kidney diseases.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.14.22279916v1" target="_blank">Humoral and Cellular Immunogenicity and Safety of 3 Doses of CoronaVac and BNT162b2 in Young Children and Adolescents with Kidney Diseases</a>
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<li><strong>The impact of COVID-19 on population cancer screening programs in Australia: modelled evaluations for breast, bowel and cervical cancer</strong> -
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<b>Background</b>&lt;br /&gt;Australia introduced COVID-19 infection prevention and control measures in early 2020. To help prepare health services the Australian Government Department of Health commissioned a modelled evaluation of the impact of disruptions to population breast, bowel and cervical cancer screening programs on cancer outcomes and cancer services.&lt;br /&gt;&lt;br /&gt;<b>Methods</b>&lt;br /&gt;We used the <i>Policy1</i> modelling platforms to estimate outcomes for potential disruptions to cancer screening participation, covering periods of 3, 6, 9 and 12 months. We estimated missed screens, clinical outcomes (cancer incidence, tumour staging), and various diagnostic service impacts.&lt;br /&gt;&lt;br /&gt;<b>Results</b>&lt;br /&gt;We estimated that a 12-month screening disruption would reduce breast cancer diagnoses (9.3% population-level reduction over 2020-2021) and colorectal cancer (up to 12·1% reduction over 2020-21), and increase cervical cancer diagnoses (up to 3·6% over 2020-2022), with upstaging expected for these cancer types.&lt;br /&gt;&lt;br /&gt;<b>Conclusions</b>&lt;br /&gt;Findings illustrate that maintaining screening participation is critical to sustaining a reduced cancer burden. We provide program-specific insights into which outcomes are expected to change, when changes are likely to become apparent, and likely downstream impacts. This evaluation provided evidence to guide decision-making for screening programs, and emphasises the ongoing benefits of maintaining screening in the face of potential future disruptions.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.11.22279831v1" target="_blank">The impact of COVID-19 on population cancer screening programs in Australia: modelled evaluations for breast, bowel and cervical cancer</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Association Between Smell Training and Quality of Life in Patients With Impaired Sense of Smell Following COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Other: Olfactory training with essential oils;   Other: Olfactory training with fragrance-free oils<br/><b>Sponsor</b>:   Ditte Gertz Mogensen<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Effects of an Investigational COVID-19 Vaccine as a Booster in Healthy People</strong> - <b>Conditions</b>:   SARS-CoV-2 Infection;   COVID-19<br/><b>Interventions</b>:   Biological: BNT162b5 Bivalent or BNT162b2 Bivalent 30 µg;   Biological: BNT162b4 5 µg;   Biological: BNT162b4 10 µg;   Biological: BNT162b4 15 µg<br/><b>Sponsors</b>:   BioNTech SE;   Pfizer<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trial of 2nd Booster Dose of COVID-19 Vaccine</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Invitation to get a 2nd booster dose of COVID-19 vaccine<br/><b>Sponsor</b>:   Norwegian Institute of Public Health<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SCALE-UP Utah II: Community-Academic Partnership to Address COVID-19 Text Message Study</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Text-Messaging (TM);   Behavioral: Patient Navigation (PN)<br/><b>Sponsors</b>:   University of Utah;   Utah Department of Health;   Association for Utah Community Health;   National Institutes of Health (NIH);   National Institute on Minority Health and Health Disparities (NIMHD)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SCALE-UP Utah II: Community-Academic Partnership to Address COVID-19 Conversational Agent Study</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Text-Messaging (TM);   Behavioral: Conversational Agent (CA);   Behavioral: Patient Navigation (PN)<br/><b>Sponsors</b>:   University of Utah;   Utah Department of Health;   Association for Utah Community Health;   National Institutes of Health (NIH);   National Institute on Minority Health and Health Disparities (NIMHD)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating the Safety and Efficacy of AD17002 Intranasal Spray in Treating Participants With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AD17002 + Formulation buffer;   Biological: Placebo<br/><b>Sponsors</b>:   Advagene Biopharma Co. Ltd.;   Gadjah Mada University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Community-Based Health Education Programs for the Early Detection of, and Vaccination Against, COVID-19 and the Adoption of Self-Protective Measures of Hong Kong Residents</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Community-based Health Education based on core intervention package;   Behavioral: Health Information Sharing Group<br/><b>Sponsors</b>:   The Hong Kong Polytechnic University;   Food and Health Bureau, Hong Kong<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Simvastatin Nasal Rinses for the Treatment of COVID-19 Mediated Dysomsia</strong> - <b>Conditions</b>:   Olfactory Disorder;   COVID-19<br/><b>Intervention</b>:   Drug: Simvastatin<br/><b>Sponsors</b>:   Washington University School of Medicine;   Duke University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Multidisciplinary Day-hospital Versus Waiting List Management of Post-COVID-19 Persistent Symptoms (ECHAP-COVID)</strong> - <b>Condition</b>:   Post COVID-19 Condition<br/><b>Intervention</b>:   Behavioral: Personalized multidisciplinary day-hospital intervention<br/><b>Sponsor</b>:   Assistance Publique - Hôpitaux de Paris<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety Evaluation of Paxlovid for COVID-19: a Real-world Case-control Study</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: standard-of-care plus Paxlovid;   Drug: standard-of-care<br/><b>Sponsor</b>:   Ruijin Hospital<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Booster Study of PTX-COVID19-B in Adults Aged 18 Years and Older</strong> - <b>Condition</b>:   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: PTX-COVID19-B;   Biological: Comirnaty®<br/><b>Sponsor</b>:   Everest Medicines (Singapore) Pte. Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Booster Superiority Study of PTX-COVID19-B Compared to Vaxzevria® in Adults Aged 18 Years and Older</strong> - <b>Condition</b>:   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: PTX-COVID19-B;   Biological: Vaxzevria®<br/><b>Sponsor</b>:   Everest Medicines (Singapore) Pte. Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cardiopulmonary Rehabilitation in Post-acute COVID-19 Syndrome</strong> - <b>Condition</b>:   Post Acute COVID-19 Syndrome<br/><b>Interventions</b>:   Other: Cardiopulmonary rehabilitation;   Other: Health education<br/><b>Sponsor</b>:   Taipei Medical University Shuang Ho Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Engaging Church Health Ministries to Decrease Coronavirus Disease-19 Vaccine Hesitancy in Underserved Populations</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Behavioral: Active Intervention Group<br/><b>Sponsor</b>:   Pennington Biomedical Research Center<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19</strong> - <b>Conditions</b>:   Long COVID;   COVID-19<br/><b>Intervention</b>:   Behavioral: Cardiac Rehabilitation<br/><b>Sponsor</b>:   University of California, San Francisco<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern</strong> - Urtica dioica agglutinin (UDA) is a carbohydrate-binding small monomeric protein isolated from stinging nettle rhizomes. It inhibits replication of a broad range of viruses, including coronaviruses, in multiple cell types, with appealing selectivity. In this work, we investigated the potential of UDA as a broad-spectrum antiviral agent against SARS-CoV-2. UDA potently blocks transduction of pseudotyped SARS-CoV-2 in A549.ACE2^(+)-TMPRSS2 cells, with IC(50) values ranging from 0.32 to 1.22 µM….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 and the potential of Janus family kinase (JAK) pathway inhibition: A novel treatment strategy</strong> - Recent evidence proposed that the severity of the coronavirus disease 2019 (COVID-19) in patients is a consequence of cytokine storm, characterized by increased IL-1β, IL-6, IL-18, TNF-α, and IFN-γ. Hence, managing the cytokine storm by drugs has been suggested for the treatment of patients with severe COVID-19. Several of the proinflammatory cytokines involved in the pathogenesis of COVID-19 infection recruit a distinct intracellular signaling pathway mediated by JAKs. Consequently, JAK…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong><em>In vitro</em> Screening of Herbal Medicinal Products for Their Supportive Curing Potential in the Context of SARS-CoV-2</strong> - COVID-19 herbal medicinal products may have the potential for symptom relief in nonsevere or moderate disease cases. In this in vitro study we screened the five herbal medicinal products Sinupret extract (SINx), Bronchipret thyme-ivy (BRO-TE), Bronchipret thyme-primula (BRO TP), Imupret (IMU), and Tonsipret (TOP) with regard to their potential to (i) interfere with the binding of the human angiotensin-converting enzyme 2 (ACE2) receptor with the SARS-CoV-2 spike S1 protein, (ii) modulate the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode</strong> - The major challenge to controlling the COVID pandemic is the rapid mutation rate of the SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the neutralizing antibodies to date. Thus, it is essential to develop neutralizing antibodies with broad-spectrum activity targeting multiple SARS-CoV-2 variants. Here, we report a synthetic nanobody (named C5G2) obtained by phage display and subsequent antibody engineering. C5G2 has a single-digit nanomolar binding affinity to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Complement C5a inhibition: a new form of COVID-19 treatment for mechanically ventilated patients?</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity</strong> - The continuous spread of SARS-CoV-2 calls for more direct-acting antiviral agents to combat the highly infectious variants. The main protease (M^(pro)) is an promising target for anti-SARS-CoV-2 drug design. Here, we report the discovery of potent non-covalent non-peptide M^(pro) inhibitors featuring a 1,2,4-trisubstituted piperazine scaffold. We systematically modified the non-covalent hit MCULE-5948770040 by structure-based rational design combined with multi-site binding and privileged…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Severe refractory warm autoimmune haemolytic anaemia after the SARS-CoV-2 Pfizer-BioNTech vaccine (BNT162b2 mRNA) managed with emergency splenectomy and complement inhibition with eculizumab</strong> - A male in his teens with a history of liver transplant for biliary atresia (aged 2 years) and autoimmune haemolytic anaemia (AIHA, aged 6 years) presented with jaundice, dark urine, fatigue and chest discomfort that began 48 hours after the first dose of SARS-CoV-2 Pfizer-BioNTech vaccine (BNT162b2 mRNA). Investigations revealed a warm AIHA picture. Over 4 weeks the patient developed life-threatening anaemia culminating in haemoglobin of 35 g/L (after transfusion), lactate dehydrogenase of 1293…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Therapeutic properties and molecular docking study of some phenolic compounds as anti-human lung cancer potential: A biochemical approach</strong> - Chloroxine (5,7-dichloro-8-hydroxyquinoline) is a molecule utilized in some shampoos for the therapy of seborrheic dermatitis of the scalp and dandruff. In this study, we investigated the inhibition effects of 5,7-dichloro-8-hydroxyquinoline and methyl 3,4,5-trihydroxybenzoate compounds on the 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA Reductase) and urease enzymes. We have obtained results for the HMG-CoA Reductase and urease enzymes at the micromolar level. In our study, inhibition result…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong><em>In silico</em> studies of M<sup>pro</sup> and PL<sup>pro</sup> from SARS-CoV-2 and a new class of cephalosporin drugs containing 1,2,4-thiadiazole</strong> - The SARS-CoV-2 proteases M^(pro) and PL^(pro) are important targets for the development of antivirals against COVID-19. The functional group 1,2,4-thiadiazole has been indicated to inhibit cysteinyl proteases, such as papain and cathepsins. Of note, the 1,2,4-thiadiazole moiety is found in a new class of cephalosporin FDA-approved antibiotics: ceftaroline fosamil, ceftobiprole, and ceftobiprole medocaril. Here we investigated the interaction of these new antibiotics and their main metabolites…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Remdesivir analog as SARS-CoV-2 polymerase inhibitor: virtual screening of a database generated by scaffold replacement</strong> - By the end of 2019, a novel strain of the corona viral family named SARS-CoV-2 emerged in Wuhan, China and started to spread worldwide causing one of the most dangerous lethal pandemics. Researchers utilized various reported inhibitors and drug databases for virtual screening analysis against this novel strain. Later on, they succeeded to fish and repurpose remdesivir, an antiviral nucleotide analogue that inhibits RNA polymerase of the Ebola virus, as a promising candidate against SARS-CoV-2….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial</strong> - BACKGROUND: COVID-19 pneumonia is associated with the development of acute respiratory distress syndrome (ARDS) displaying some typical histological features. These include diffuse alveolar damage with extensive pulmonary coagulation activation. This results in fibrin deposition in the microvasculature, leading to the formation of hyaline membranes in the air sacs. Well-conducted clinical trials have found that nebulised heparin limits pulmonary fibrin deposition, attenuates progression of ARDS,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture</strong> - Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro, HCQ effectively inhibits viral entry, but its use in the clinic has been hampered by conflicting results. A better understanding of HCQ’s mechanism of actions in vitro is needed. Recently, anesthetics were shown to disrupt ordered clusters of monosialotetrahexosylganglioside1 (GM1) lipid. These same lipid clusters recruit…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring experiences with telehealth-delivered allied healthcare services for people with permanent and significant disabilities funded through a national insurance scheme: a qualitative study examining challenges and suggestions to improve services</strong> - CONCLUSIONS: Some people with permanent and significant disabilities who accessed allied healthcare via telehealth during the pandemic experienced challenges, particularly children. These unique barriers to telehealth need customised solutions so that people with disabilities are not left behind when telehealth services become more mainstream. Increasing experience with telehealth, setting expectations before consultations, supplying resources for therapy and assessing the suitability of clients…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Disinfection effect of hexadecyl pyridinium chloride on SARS-CoV-2 in vitro</strong> - The novel coronavirus (COVID-19 or 2019-nCoV) is a respiratory virus that can exist in the mouth and saliva of patients and spreads through aerosol dispersion. Therefore, stomatological hospitals and departments have become high-infection-risk environments. Accordingly, oral disinfectants that can effectively inactivate the virus have become a highly active area of research. Hexadecyl pyridinium chloride, povidone-iodine, and other common oral disinfectants are the natural primary choices for…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host</strong> - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections generate approximately one million virions per day, and the majority of available antivirals are ineffective against it due to the virus’s inherent genetic mutability. This necessitates the investigation of concurrent inhibition of multiple SARS-CoV-2 targets. We show that fortunellin (acacetin 7-O-neohesperidoside), a phytochemical, is a promising candidate for preventing and treating coronavirus disease (COVID-19) by…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>China and the Lore of American Manufacturing</strong> - In Ohio’s Senate race, both candidates are employing anti-Asian rhetoric and neglecting to hold corporations to account. - <a href="https://www.newyorker.com/news/dispatch/china-and-the-lore-of-american-manufacturing">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Hopeful Should Democrats Be About the Midterms?</strong> - The fight for abortion rights, recent legislative gains, and “candidate quality” have improved the Party’s chances in many polls, but a renewed sense of optimism might be misplaced. - <a href="https://www.newyorker.com/news/the-political-scene/how-hopeful-should-democrats-be-about-the-midterms">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Inflation Picture Isn’t as Negative as Republicans and the Markets Are Saying</strong> - Prices are gradually declining over all, and the Fed chief, Jerome Powell, should resist calls for more drastic interest-rate increases. - <a href="https://www.newyorker.com/news/our-columnists/the-inflation-picture-isnt-as-negative-as-republicans-and-the-markets-are-saying">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Charles III and Climate Change in the U.K.</strong> - Not only is the new king supposed to stop pushing for green political policies; he faces a new Prime Minister who plans to reverse them. - <a href="https://www.newyorker.com/news/daily-comment/charles-iii-and-climate-change-in-the-uk">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Second Trump Term Would Be a Scary Rerun of the First</strong> - Remember those “Jurassic Park” velociraptors learning how to open the door? - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/a-second-trump-term-would-be-a-scary-rerun-of-the-first">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Are weather apps lying? The truth is in the dew point.</strong> -
<figure>
<img alt="A dark-haired man in a light purple shirt and light blue pants walks away from the camera on a city street, in bright sunlight. His shirt has a soaked patch where sweat is spreading across his back." src="https://cdn.vox-cdn.com/thumbor/HV2UxEzOshW5J3Z7p24A71pxFdo=/0x0:4567x3425/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71375577/1233729033.0.jpg"/>
<figcaption>
This man is sweaty. I empathize with his pain. | Michael Nagle/Xinhua via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Not all 75°F days are created equal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fKDtEM">
When a 72-degree day feels like a swampy armpit, I start to realize that everything I’ve ever thought I understood about weather, mainly temperature, is a lie. Sweating through my shirt, wiping my brow, and staring in disbelief at my weather app wondering, “How could this be the 72°F I know and love?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bshADE">
Thankfully, I’ve found a better number to tell me how it’s going to feel outside — and it’s not the relative humidity, which is also a sham. It’s the dew point.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PhxJ8Q">
The lower it is — ideally in the 50s to 60s — the less sticky it will feel. The higher it is (70s) the closer it will be to my personal hell. (The relative humidity, a sometimes popular metric, measures the dew point against the temperature, making it particularly unhelpful on very, very hot days, when the temperature may be much higher than a relatively low, but still uncomfortable, dew point.)
</p>
<div class="c-float-right">
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<div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="skrWmr">
In an effort to better explain why the dew point is the superior way to tell the weather and what it exactly means, I spoke with John Homenuk on a recent rainy, uncomfortably sweaty afternoon. Homenuk, who studied meteorology at Kean University, is a dew point enthusiast and the reason I found out about dew point forecasts in the first place. He’s the force behind the <a href="https://twitter.com/nymetrowx">New York Metro Weather</a><strong> </strong>Twitter account.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WQbS0y">
New York Metro Weather has a 58,000-plus following that looks to it to answer a really simple question: Is the weather in New York City today going to be good or bad? Homenuk gives his followers a vibe rating out of 10 (sunny, humidity-free days score the highest) and sprinkles in a brief explanation of why it will or won’t be a pleasant day in New York.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D7lgGP">
As Homenuk confirmed to me, not all 72°F days are created equal — and the dew point might be the best explanation why.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IiI0ZP">
<strong>It’s a pleasure to speak with you. In your words, the vibes in New York are awful today.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TxOx5j">
Yeah. We kind of need it though. We’ve been in such a bad drought. Sometimes I have to try really hard to keep what we need in terms of weather away from what the actual vibe is — today is definitely two out of five.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fx6Q5T">
<strong>I think what makes it stink is that it’s very sticky outside. It feels like I’m in a low-temperature sauna.</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SYwwNI">
Right! Like a cooler rainy day is pretty nice.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ek5fre">
<strong>Yeah, and I wanted to ask you about what makes it </strong><em><strong>feel</strong></em><strong> cooler.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2UDc9l">
<strong>I’m recently — in large part because of your Twitter feed — a dew point convert. The dew point is high today and it feels disgusting. And I know that the weather feels better when the dew point is lower.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XX9B1i">
<strong>But I don’t get why, or what it is. What is the dew point, and why does it feel so good when it’s low?</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YGoVPb">
Well, first of all, dew point is just a great measure of how it’s going to feel outside. I think temperature is just as important with humidity, but relative humidity, like the relative humidity that’s on our weather apps, is just a total crock. Because it’s not — it’s literally relative to the temperature, so it’s not helpful.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1L7pLc">
<strong>Okay, say more.</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9q9D4C">
Relative humidity doesn’t help me fully understand what it’s going to feel like outside. Whereas the dew point, in a very basic sense: It’s the amount of moisture in the atmosphere.
</p>
<figure class="e-image">
<img alt="A close-up photo of Rafael Nadal shows the tennis player’s face in profile, looking down at the court. He wears a purple T-shirt and a bright pink headband, and his dark hair is soaked with sweat that drips down from all over his face, a large droplet falling from his chin." src="https://cdn.vox-cdn.com/thumbor/jxm69xHfd-_hmlficbr9oWs1Zqs=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24021841/1419502192.jpg"/> <cite>Eduardo Munoz Alvarez/VIEWpress</cite>
<figcaption>
This is a picture of Rafael Nadal from the US Open a couple of weeks ago. Look how much he is sweating! I have no idea why the US Open is played during the hottest and steamiest part of August.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I4DUDd">
The higher the dew point is, the greater the amount of moisture in the air. And so when the dew point is higher, the air is holding more moisture content and it feels more uncomfortable. When the dew point is lower, obviously, there’s less moisture in the air, and it feels more comfortable to be outside in general. The other threshold is when the dew point gets too low, when it’s too dry, and that’s when you have chapped lips instantly, and it’s winter time.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Px7TsY">
<strong>That’s when you have to turn on the humidifier.</strong>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KBziVI">
Exactly. But there’s definitely a “Goldilocks zone” where the dew point is, like, 55°. 50° to 60° is generally pretty, pretty perfect. It just feels pretty great out there.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l5437h">
I always like to think about this: If the dew point is 75° but your temperature is 100°, your relative humidity is going to be low, because relative humidity is calculating the relationship between the temperature and the dew point. But you and I both know, because we know dew point, it’s going to be hot as heck out there.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tAQzU0">
<strong>Based on what you’re saying to me, and based on my very elementary knowledge of the dew point, my calculation is that that sounds extremely disgusting.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l4rrsT">
Okay, so I did the calculation. If you have a temperature of 100° and a dew point of 75°, that would give you a relative humidity of around 45 percent. So if I checked nothing but the relative humidity, I’d be like, “Oh, it’s 45 percent.” If I go outside, I will just be hit by this wall of death and sweat.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1RQr1R">
<strong>“45 percent relative humidity” in my chicken weather brain would sound like a dry heat. I don’t mind a dry heat — Arizona is fine! </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ODfCKj">
And we’d be so wrong. I use the dew point alone, because it’s a standalone measure of how much moisture is in the atmosphere. When the dew point is at 75°, everyone knows that it’s going to feel terrible. And so that’s the real value of the dew point.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IoWb9k">
<strong>It’s like a language to alert everyone that it’s going to be horrific outside.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fnY585">
<strong>I’m of a firm belief that not all 72° temperatures are created equal. The 72° in fall feels a lot different than the 72° in spring and the 72° in summer. My hunch is that this has to do with the dew point. </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8TM6Aq">
Well, I think it’s also a lot of perception. We perceive things differently. When you come out of winter, into spring, and you get the first kind of hot day, I really feel that 70° is gonna feel a lot different than the 70° will in August. That’s a whole other discussion.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sGNKSs">
But forget the month. If you have a temperature of 75° and your dew point is 40°, it’s going to feel nice outside. The dew point is low, the temperature is 75°. And it’s a beautiful day. If it’s 75° outside with the dew point at 72°, you’re going to feel like you’re in a sauna because the dew point is so high.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uLHs0p">
<strong>Let’s say we only look at the dew point to plan our day: What information might we be missing, and are we cool with missing that?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T94iSj">
I like to say that the dew point is only one piece of the puzzle. For one thing, the dew point can change dramatically throughout the day. It can be a miserable 75°F in the morning, only to drop into the comfortable 50s thanks to an afternoon cold front. But more importantly, the dew point is just one piece of information in a larger picture. There are so many different intricacies to the weather that decide how it feels outside: Temperature, dew point, wind, clouds, precipitation. While dew point is important, it’s also important to look at it in the proper context.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f5IeDB">
<strong>I want to zoom out a little bit and ask you about your vibe calculation. What factors into a good weather vibe and what factors into a bad weather vibe? It’s subjective, but is it relative?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="poQACt">
To me, what I try to hold strong to is the idea of what a perfect weather day is, and to me those days are, you know, upper 60s to the 70s temperatures, low dew points, a nice wind and lots of sun, and we don’t want clouds or rain — those bring the numbers down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hxVo4r">
You don’t want too much wind, where it’s uncomfortable and annoying to be outside. And obviously you don’t want it to be too hot, too cold, or too humid.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Nz3qgi">
I feel like there’s this Goldilocks zone of 70s temperatures and 50s dew points, which is kind of like the perfect day. But you’re right. There’s definitely some days in winter and summer that kind of become a judgment call.
</p>
<figure class="e-image">
<img alt="A long view shows a wide stretch of light sand California beach on a sunny day with small, faraway beachgoers along the edge, curving around a calm blue Pacific Ocean bay filled with small boats just offshore. In the background, mountains rise into an intensely blue sky." src="https://cdn.vox-cdn.com/thumbor/AGij6hmPI2dJLnru8Fxb7gNbS-E=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/24021850/1242973906.jpg"/> <cite>Tayfun Coskun/Anadolu Agency via Getty Images</cite>
<figcaption>
This is Santa Barbara, California. This is where some of the most perfect weather exists. Nancy Meyers wouldn’t set a movie (<em>It’s Complicated</em>) here if it wasn’t perfect.
</figcaption>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2yBYtY">
But I try my very best to remain as unbiased as possible and stick to the original idea, which is that there is a perfect weather day in New York. Those are the only ones that I can give a perfect rating. And then there’s a worst-case weather day in New York, which is our only ever 0 out of 10, which was last year during the floods in September — the <a href="https://www.vox.com/2021/9/2/22652426/hurricane-ida-disaster-recovery-climate-change-policy">remnants of Hurricane Ida</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ha9Zj9">
There’s definitely a formula for what the perfect day is. There’s some differences individually too. And it changes by the season a little bit.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LsypGR">
<strong>You mentioned that you try to be balanced and unbiased. And I think we got that earlier when you said, “Oh, yeah, we need the rain.” Rain obviously has bad vibes and lower numbers, but if we need it, do you make a note of it?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4sBn2Q">
The weather vibe is separate from the need, you know? Because if we start rating weather based on all these outside influences, then the rating is not the true rating anymore.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="irUvyn">
<strong>Yeah, I get it. If we got that weird 80° day in the middle of winter, I’m sure that will score good vibes — but you’re probably thinking of climate change and how this is actually kind of concerning.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="85cybg">
I mean, I’ve gotten that from people. There were a couple of days last year where it was warm out during the winter. It was in February, and someone replied, “You know, just me enjoying the end of the world in my sunglasses.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pdnyXp">
But if you’re rating the weather and you start adjusting the rating based on outside influences like that, you’re getting into a really complicated zone where you have to think about climate change or drought.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iFvs9n">
<strong>Basically your rating isn’t a treatise on climate change. It’s just about whether there are good vibes or bad vibes outside today.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SSjviT">
Exactly. It’s like, am I gonna have a good time? Or am I gonna have a bad time out there? That’s pretty much it. I always say to people that the way that I try to look at it is: When I step outside, how am I going to feel? Am I going to be miserable?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7eEpEz">
When you go out to get a coffee, or you go to work, or when you get on the subway, what are you going to feel? What’s the vibe of the day? I try to keep it simple in that sense.
</p></li>
<li><strong>How to hold your elected officials accountable</strong> -
<figure>
<img alt="A cartoon drawing of a man and a woman standing side by side speaking into megaphones." src="https://cdn.vox-cdn.com/thumbor/z674B22l4_l_qpricVZfj1L6wSE=/153x0:2588x1826/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71375339/GettyImages_1337210532.0.jpg"/>
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Denis Novikov/Getty Images
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A crash course in political engagement.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FQ1yxB">
In 2016, Michigan’s congressional districts were <a href="https://www.bridgemi.com/michigan-government/gerrymandering-michigan-among-nations-worst-new-test-claims">among the most gerrymandered in the country</a>, heavily favoring Republicans despite Democrats winning equal or more votes in local races. Frustrated, a group of Michigan voters with no political experience connected via Facebook to create a grassroots anti-gerrymandering campaign called <a href="https://votersnotpoliticians.com/">Voters Not Politicians</a>, collecting over 400,000 signatures in support of <a href="https://www.michiganradio.org/politics-government/2017-12-18/grassroots-group-one-step-closer-to-overhauling-redistricting-in-michigan">a ballot measure to redistrict the state</a>. In November 2018, 61 percent of voters cast their ballot to support the creation of an independent citizens redistricting commission. “In Michigan, now we have the benefit of more competitive districts because we ended gerrymandering,” says <a href="https://votersnotpoliticians.com/about/team/nancy-wang/">Nancy Wang</a>, the executive director of Voters Not Politicians.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TCfquM">
In the case of Voters Not Politicians, their strategy was to demand a fairer system and to hold the powers that be to task for changing that system. Average citizens identified a problem and worked together to institute a change — and you can, too. While the political landscape <a href="https://www.vox.com/policy-and-politics/2021/12/9/22824509/summit-for-democracy-biden-america">can look dire</a>, constituents shouldn’t feel powerless. “You actually have a lot of power,” Wang says. “Especially now, it’s people banding together. That’s how we change the system so it works for voters again.” A crucial aspect of our fragile democracy is to make our voices heard, both in times when the public is focused on core issues and when lawmakers are under less scrutiny.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8Bm6Nq">
From issues impacting the country on a national level, like <a href="https://www.vox.com/2022/8/24/23319967/student-loan-payments-debt-forgiveness-biden">student loan forgiveness</a> or <a href="https://www.vox.com/policy-and-politics/2022/8/22/23306142/kaine-collins-codify-roe-abortion-congress">reproductive rights</a>, to local concerns, like <a href="https://www.vox.com/22671552/bike-infrastructure-funding">bike safety</a> and <a href="https://www.vox.com/23178172/public-school-funding-inequality-lawsuit-pennsylvania">school funding</a>, individuals have plenty of tools available to hold their lawmakers accountable on promises they’ve made to their constituents.
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<h3 id="PSOMQG">
Find causes you’re passionate about
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WXD0Va">
<a href="https://www.vox.com/climate-change">Climate change</a>, <a href="https://www.vox.com/lgbtq">LGBTQ rights</a>, <a href="https://www.vox.com/gun-violence-shootings">gun violence</a>: It’s easy to doomscroll and fall into a pit of despair thinking about the sheer amount of progress that hasn’t been made. Instead of spreading yourself thin across multiple causes — or worse, doing nothing because you don’t know where to start — put your efforts into a cause close to your heart. Have your kids been affected by cuts to school funding? Are you a cyclist who’s frustrated by a lack of bike lanes in your town? Does the news of abortion bans light a fire within you? Look to your emotions and probe your passions to find an issue you’ll want to spend time and resources supporting, ideally over an extended period.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S4QzAq">
“You have to find a personal tie to any issue that you’re deciding to champion so that you can really connect with people who are also impacted by that issue,” says Philadelphia-based public health activist <a href="https://www.alexandramhunt.com/">Alexandra Hunt</a>. “If there isn’t that personal tie, the activism that you might get involved with can feel a little empty to both yourself and to others involved.”
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<h3 id="lz5fhN">
Who to talk to
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="726Nxd">
While national issues get a fair amount of media attention, your efforts will make the most impact on a local level. For example, abortion and reproductive rights have been a topic of national conversation since <em>Roe</em> was overturned in June, but laws banning abortion are passed on a state level. Every law or political agenda item can be <a href="https://www.vice.com/en/article/wx849w/how-to-find-and-bug-the-correct-local-politician-to-actually-get-stuff-done">traced back to someone or some group</a>. Concerned about local funding for police departments? The mayor and town council work together to set and pass the budget. If you’re passionate about housing and construction in your town, you’ll want to get in touch with the town <a href="https://en.wikipedia.org/wiki/Planning_and_zoning_commission">planning and zoning</a> committee or board. Want stricter gun laws passed in your state? Your state legislator is the person to contact.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KsK1Rm">
Online tools like <a href="https://openstates.org/find_your_legislator/">Find Your Legislator</a> allow you to enter your address and will then display your legislators on the state and federal levels. Your town and state websites will have lists of representatives, the mayor, council and board members, and other elected officials.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WHOnen">
Research these legislators’ voting histories. In order to hold lawmakers accountable, you should be prepared to reference their past actions and statements. If a state senator ran on protecting abortion access and then votes for bills restricting or banning abortion, that’s information you’ll want to know. “We have receipts, we have proof,” says <a href="https://now.org/staff/christian-f-nunes/">Christian F. Nunes</a>, the president of the <a href="https://now.org/">National Organization for Women</a>. “And we’re able to hold people accountable by their words that they have said and the promises that they have made. If they’re not living up to what they’ve promised … we have the right to call them on what they have or have not done.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EIxbKK">
Especially as <a href="https://www.vox.com/midterm-elections-2022">midterm elections approach</a> and candidates up and down the ballot make attempts to appeal to voters, declaring their legislative intentions should they win their races, citizens can use these campaign promises as benchmarks for their legislators’ willingness to follow through. Campaign websites are great documents to reference when comparing lawmakers’ promises versus their actions, Nunes says.
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For more context, read your local newspaper, including the editorial and op-ed pages, and follow coverage of your community, Wang says, to stay abreast of who’s championing what topic.
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<h3 id="uP33Ty">
Getting on their radar
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tsvm4W">
Securing time with a lawmaker doesn’t have to be mystifying. Their job is to connect with the people they represent. First, start with city council, county commission, school board, zoning, or other local legislative meetings, like town halls. If there is a public comment portion of the meeting, you’ll have a chance to speak up then.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gmhLqL">
Remember, elected officials are regular people outside of their roles and you should feel comfortable talking with them the same way you would communicate with a friend, Wang says. Keep the lines open and you’re likely to forge an ongoing conversation. “When something comes up that concerns you, or when they do something you approve or disapprove of, give the office a call, send an email, tag them in a post, slide in their DMs,” she says. Once you’re in regular contact with the lawmaker and their office, they may give you more direct means of communication with the elected official, like their personal phone number. “Then you can just continue to share your thoughts and concerns with them,” Hunt says.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4ebzpR">
If you’d like to request a meeting, find your state or federal lawmaker’s website and send an email or fill out the contact form specifying that you’re a constituent, what you’d like to talk about, <a href="https://www.aclu.org/meeting-your-elected-representatives">a bill number, if possible, and dates you can meet.</a> For <a href="https://www.senate.gov/senators/senators-contact.htm">US senators</a> and <a href="https://www.house.gov/representatives">representatives</a>, make sure you’re reaching out to their local office and not their Washington, DC, office. You can follow up with a call to their offices to speak with a staffer to schedule a meeting if you haven’t heard back in a few days. Be aware that you may not get face time with the lawmaker, but with a member of their staff instead — that’s fine and shouldn’t impact the nature of your message. “Make sure you build a relationship with everyone involved and don’t mistreat anyone because the elected didn’t show,” Hunt says.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gRzARc">
Once you’ve secured a meeting, make sure you arrive early, keep your talking points succinct and impactful (more on this below), and make sure you’ve done your research into the issue at hand. Avoid arguments and name-calling, even if you disagree with what the elected official is saying. Be <a href="https://www.thoughtco.com/meeting-with-your-members-of-congress-3322076">concrete in your ask</a> — confirmation they will vote for additional arts funding in the budget, that they will address unsafe intersections where multiple accidents have occurred — and find out when you can follow up with them to hear their plan for moving forward.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dKOdRz">
After, send a thank-you note that reiterates your message and includes any supplemental materials like facts and statistics the elected official may have asked for.
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<h3 id="1CFSdh">
Sharing your message
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5jXuzr">
So you’ve found your cause, the lawmaker responsible for making change (or not fulfilling their end of the bargain), and you have time on the calendar. Now to craft your message. Hunt suggests focusing on personal stories — either your own or someone else’s (with their permission) — of how you’ve been affected by recent laws or lack thereof. You can share how it feels to be a pregnant person in a state with an abortion ban, or how student loan debt is preventing you from building your savings.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BSKiSo">
Utilize your research into this lawmaker during these personal appeals, Hunt says. You can say, “I know you’re really passionate about ending gun violence because it impacted your family,” or, “I know you don’t often discuss voting rights but I’d love to tell you how this affects my life.” “Tying into what’s important to them and why they have to champion [this issue] leads to that bond of understanding between two people,” Hunt says.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jEQWPt">
Don’t forget the power in positive messages, too, Wang says. When a local politician follows through on campaign promises or introduces legislation after speaking with members of the community, reach out to voice your support and to share how these changes would affect your life. Your representative can use those positive stories when arguing for how their proposed legislation would impact constituents.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JocESt">
You can share these stories via email, by a phone call to your rep’s office, on social media, or in person at council or legislative meetings by scheduling an appointment during their office hours, or while they’re attending community events.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ajv6PI">
If you’re a member of an organization, the organization can provide training or talking points on how to converse with lawmakers. However, try thinking of the conversation as just that: a conversation. These legislators were elected to serve the people, and that’s you. You have every right to make your concerns heard. “They are also considered employees of yours, when you think about it,” says <a href="https://www.equal-ground.com/jasmine-burney-clark">Jasmine Burney-Clark</a>, founder and consulting director of <a href="https://www.equal-ground.com/">Equal Ground</a>, a Black-led, nonpartisan, nonprofit organization working to build Black political power in Florida. “Don’t fear asking an employee about their work performance. They owe you that.”
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<h3 id="hex3qz">
Making a habit of communicating with your legislators
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0YM2ki">
Ideally, you’ll want to make regular check-ins with lawmakers, and not only when they’ve dropped the ball or after a major news event. Continue to show up to meetings, town halls, or coffee chats if local elected officials hold them. “Connecting with them outside of their office in the community will help keep you in the front of their mind for when you need a meeting or a call,” Nunes says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RBDwp9">
Introduce yourself to local leaders at community events, Hunt says, and give them a brief overview of the issue you’re passionate about so you can become a familiar face amid their constituency. “If you’re a housing activist, make sure you tell them that as you’re shaking their hand and tell them your intentions,” Hunt says. “And then the lawmaker or their staff can take your information or provide you with information on how best to get in touch to get a response.” She recommends saying something like, “Hi, [elected official name], so nice to meet you. I’m [your name] and I’m pretty involved in what’s going on with [public health, housing, voting rights]. What’s a good way to reach out to your office to set up a meeting and discuss this?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1Genz2">
If you’re a part of a grassroots or activist group, invite legislators to your regular meetings to give them an opportunity to work with you, and follow your lawmakers on social media to stay connected on their activity, Nunes says. Replying to a tweet or a Facebook post or sending a DM are low-stakes ways to vocalize your opinion.
</p>
<h3 id="URL4oy">
When you’re not being heard
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HuDFMu">
Despite all your best efforts, you may feel like your concerns are being overlooked. This is when having those receipts comes in handy, Nunes says. You can make an appeal on Twitter, at a public hearing or a council meeting, sharing how you’ve made plenty of attempts to discuss the matter with your representative and they’ve made promises they haven’t fulfilled. You can say something like, “You promised you were going to [introduce street sweeping/protect access to abortion/increase funding for parks], but I see you doing something else instead. Can you explain this?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GwJ6c9">
The more people who voice these concerns, the more powerful the message will be. Encourage others in your community or activist group to speak out at meetings and to write emails highlighting contradictions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mK9GZp">
If all else fails, vote them out. Find and support (financially, vocally, or by volunteering for their campaign) a candidate who will be receptive to constituents’ needs and who has similar views on the issues of importance to you.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JABSXZ">
“We need to start tapping more into our strength as voters,” Nunes says, “and not tolerating people just because they think they have more power.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3gyBc2">
<a href="http://www.vox.com/even-better"><em>Even Better</em></a><em> is here to offer deeply sourced, actionable advice for helping you live a better life. Do you have a question on money and work; friends, family, and community; or personal growth and health? Send us your question by filling out this </em><a href="https://docs.google.com/forms/d/e/1FAIpQLSfiStGSlsWDBmglim7Dh1Y9Hy386rkeKGpfwF6BCjmgnZdqfQ/viewform"><em>form</em></a><em>. We might turn it into a story.</em>
</p></li>
<li><strong>Three takeaways from that Trump judge’s latest order in the Mar-a-Lago case</strong> -
<figure>
<img alt="Former President Trump Holds Campaign Rally In Pennsylvania To Support Local Candidates" src="https://cdn.vox-cdn.com/thumbor/lt3hai3BKZqWOp2rjW7T3JP0TeE=/255x0:4326x3053/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71374419/1420629540.0.jpg"/>
<figcaption>
Former president Donald Trump speaks to supporters at a rally to support local candidates on September 03, 2022 in Wilkes-Barre, Pennsylvania. | Photo by Spencer Platt/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Trump Judge Aileen Cannon’s latest order shows a disregard for established law.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xwdEP9">
Judge Aileen Cannon, the Trump-appointed judge recently known for <a href="https://www.vox.com/policy-and-politics/2022/9/6/23339017/trump-fbi-mar-a-lago-aileen-cannon-judge-special-master-supreme-court-executive-privilege">twisting the law in knots</a> in ways that undermine one of the Justice Department’s criminal investigations into former President Donald Trump, has <a href="https://storage.courtlistener.com/recap/gov.uscourts.flsd.618763/gov.uscourts.flsd.618763.89.0_1.pdf">issued a new order</a> that, well, twists the law into knots.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zTTJAi">
Last month, the FBI <a href="https://www.vox.com/policy-and-politics/2022/8/9/23297734/donald-trump-mar-a-lago-fbi-raid">executed a search warrant at Mar-a-Lago</a>, Trump’s Florida residence, and seized several boxes of documents. They include <a href="https://www.vox.com/policy-and-politics/2022/9/8/23343477/trump-mar-a-lago-fbi-documents-national-security-fbi-justice-department-doj">103 documents with classified markings</a>, some of them indicating that the information contained in those papers are classified at the highest levels. According to the Washington Post, these papers include “a document describing a foreign government’s military defenses, <a href="https://www.washingtonpost.com/national-security/2022/09/06/trump-nuclear-documents/">including its nuclear capabilities</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9Lpbiw">
Trump’s legal team has been waging a campaign in Cannon’s court to hinder the DOJ’s ability to look into those documents. Cannon on Thursday gave Trump another win in that campaign, although her latest order does slightly narrow one of Trump’s earlier victories in her courtroom.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HFgxpk">
The Constitution provides several safeguards against unreasonable searches and seizures by law enforcement. The FBI must have probable cause to justify a search of a private residence, and it must obtain a warrant issued by a neutral magistrate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RiX8fu">
Although DOJ complied with these constitutional requirements, Cannon issued an order earlier this month arguing that Trump is entitled to special protections that are rarely afforded to any criminal suspect, in large part because of Trump’s “<a href="https://www.vox.com/policy-and-politics/2022/9/6/23339017/trump-fbi-mar-a-lago-aileen-cannon-judge-special-master-supreme-court-executive-privilege">former position as President of the United States</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kvBHl2">
Specifically, Cannon ordered the Justice Department to halt its criminal investigation into Trump until a court-appointed official known as a “special master” reviews the seized documents.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AbdN7f">
Although Cannon’s original order permitted DOJ to continue a parallel national security investigation assessing how Trump’s possession of these documents may have damaged national security, DOJ informed Cannon in a motion filed last week that <a href="https://www.vox.com/policy-and-politics/2022/9/8/23343477/trump-mar-a-lago-fbi-documents-national-security-fbi-justice-department-doj">these two investigations “cannot be readily separated,”</a> in large part because they are being conducted by the same personnel.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qQEt5c">
In last week’s motion, DOJ asked Cannon to allow its criminal investigation to continue with respect to the 103 classified documents. On Thursday, Cannon formally denied that request, and appointed Raymond Dearie, a senior federal judge, as that special master to review all of the documents seized from Trump for indications that they may be protected by attorney-client or executive privilege. Cannon also instructs Dearie to begin his review with the classified documents.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fHugMn">
DOJ has already indicated that it will seek relief from a federal appeals court, possibly as soon as tonight. The case is called <em>Trump v. United States</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q2XzMU">
But there are several things worth digging into with Cannon’s order first.
</p>
<h3 id="Kh5F1S">
Cannon’s new order suggests that Trump could somehow own classified government documents
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ykh70H">
Cannon’s original order rests on the proposition that Trump has made a plausible case that he has a “<a href="https://storage.courtlistener.com/recap/gov.uscourts.flsd.618763/gov.uscourts.flsd.618763.64.0.pdf">right to possess at least some of the seized property</a>.” But, as the Justice Department noted in last week’s motion, Trump “does not and <a href="https://storage.courtlistener.com/recap/gov.uscourts.flsd.618763/gov.uscourts.flsd.618763.69.0_2.pdf">could not assert that he owns or has any possessory interest in classified records</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OqKNWV">
Classified documents by definition belong to the federal government and not to a private individual — indeed, the whole point of classifying a document is to prevent that document from coming into the possession of anyone that the government does not want to see it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3j5TK4">
Moreover, the FBI says that some of the relevant documents are marked as “<a href="https://www.vox.com/policy-and-politics/23306941/donald-trump-crimes-criminal-investigation-mar-a-lago-fbi-january-6-election-georgia-new-york">classified/TS/SCI</a>,” a designation that refers to “sensitive compartmented information” — information that is typically stored in specialized facilities to prevent the information from getting out.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fGrQ6a">
In her recent order, Cannon essentially says that <a href="https://storage.courtlistener.com/recap/gov.uscourts.flsd.618763/gov.uscourts.flsd.618763.89.0_1.pdf">the FBI cannot be trusted</a> when it claims that these documents are classified. “The Court does not find it appropriate to accept the Government’s conclusions,” Cannon writes, that “all of the approximately 100 documents isolated by the Government (and “papers physically attached to them”) are classified government records.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tQy7bb">
Such skepticism of a law enforcement’s agency’s assertions might be <a href="https://deathpenaltyinfo.org/news/new-york-judge-finds-prosecutor-lied-to-convict-three-men-wrongfully-imprisoned-in-1990s-death-penalty-case">welcome in another context</a>. But, again, the Constitution lays out the requirements that the FBI must comply with in order to seize documents and use them in a criminal investigation — probable cause plus a warrant — and the FBI complied with these constitutional obligations.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EaSY71">
If Trump believes that some of these documents were unlawfully seized from him, he can <a href="https://www.vox.com/policy-and-politics/2022/9/6/23339017/trump-fbi-mar-a-lago-aileen-cannon-judge-special-master-supreme-court-executive-privilege">raise that argument at his criminal trial</a>, if he is ever indicted, and seek to have the documents excluded from that trial. He could do, in other words, what every other criminal defendant is permitted to do.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QQseHG">
But Cannon is giving him additional protections that virtually no criminal suspect enjoys, based largely on the fact that he used to be president.
</p>
<h3 id="bAdCq4">
Cannon gives the Justice Department a little more leeway, but probably not enough that they can safely make use of it
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7DhRVG">
Recall that Cannon’s original order said that the FBI could continue its national security investigation into how Trump’s possession of these documents may have damaged the nation’s intelligence interests, but that it must pause its criminal investigation. In response to DOJ’s argument that these two investigations are difficult to disentangle, Cannon essentially replies that “difficult” does not mean “impossible.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="euFjWB">
One of the government’s filings, she notes, “states that it would be ‘exceedingly difficult’ to bifurcate the personnel involved in the described processes.” But “exceedingly difficult,” she claims, is not the same thing as “inextricably intertwined.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3RumDK">
That said, Cannon’s <a href="https://storage.courtlistener.com/recap/gov.uscourts.flsd.618763/gov.uscourts.flsd.618763.89.0_1.pdf">latest order</a> does contain some language suggesting that DOJ can continue some parts of its criminal investigation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1l7Bm8">
Though Cannon forbids the Justice Department from “presenting the seized materials to a grand jury and using the content of the documents to conduct witness interviews as part of a criminal investigation” — a restriction that effectively precludes DOJ from indicting Trump until Cannon’s order is lifted — she does write that “to the extent that the Security Assessments truly are, in fact, inextricable from criminal investigative use of the seized materials,” then the criminal investigation may continue.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BfOcMF">
In practice, however, it is far from clear that the Justice Department can take advantage of this concession by Cannon. Cannon’s new order contains only limited descriptions of what DOJ can and cannot do. And it is possible that the FBI will be unwilling to make its own judgment calls so long as it knows that a seemingly hostile judge may hold them in contempt if she disagrees with the FBI’s judgment.
</p>
<h3 id="KzBk8I">
Cannon seems to have no idea how classified documents work
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JYD5Zw">
One other line in Cannon’s opinion is worth noting. In its motion from last week, the Justice Department argued that “the Court’s order would irreparably harm the government and the public by unnecessarily requiring the government to share highly classified materials with a special master.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5DlxaP">
As the Supreme Court held in <a href="https://supreme.justia.com/cases/federal/us/484/518/"><em>Department of the Navy v. Egan</em></a> (1988), “For ‘reasons . . . too obvious to call for enlarged discussion,’” determinations about who should be allowed to see classified documents “must be committed to the broad discretion of the agency responsible, and this must include broad discretion to determine who may have access to it.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="udpMtS">
But Cannon’s order effectively brings the special master, who does not have a “need to know” the information in the classified documents that is grounded in national security concerns, inside the community of individuals who are allowed to see specific highly classified documents. That places her order at odds with <em>Egan</em>, and with ordinary practices governing the nation’s most highly guarded secrets.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RraOVj">
In any event, the most important upshot of Cannon’s order is that DOJ is now free to seek relief from a higher court. It is likely that they will do so as fast as their lawyers can draft the appropriate motion.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>To create Hardik Pandya's back-up, selectors include Raj Angad Bawa in India A squad</strong> - Sanju Samson will be leading the India A side in the three-match ODI series against New Zealand A starting September 22</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Annar nets four goals</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Erling Haaland is Premier League Player of the Month in August</strong> - In his first five games for Manchester City, Erling Haaland has scored nine goals. Only former Liverpool striker Luis Suarez has scored more goals (10) in a single month in the Premier League</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mark Boucher named head coach of Mumbai Indians</strong> - South Africa head coach Mark Boucher will replace former Sri Lanka skipper Mahela Jayawardene as head coach of Mumbai Indians for the next IPL season</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Two entries for shooting Worlds defy norms</strong> - Special Correspondent</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>REC, PFC resume release of loans</strong> - Major power, irrigation project works in TS set to pick up pace</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>BJP flays removal of book on PM from Calicut university’s library</strong> - Surendran says party will organise book fests across Kerala in protest</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra Pradesh: Enforcement Directorate officials raid Ongole MP’s premises</strong> - The searches are a part of the probe into ‘Delhi liquor scam’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PM Modi meets Turkish President Erdogan; discuss ways to deepen bilateral cooperation in diverse sectors</strong> - The Turkish President, a close ally of Pakistan, had repeatedly referred to the Kashmir issue in his address at the UN General Assembly sessions.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Roads in Kerala under running contract to be inspected from September 20, says Minister for Public Works P. A. Mohamed Riyas</strong> - Minister calls for innovative, sustainable construction methods</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Hundreds of graves found in liberated Izyum city - officials</strong> - More than 400 bodies are thought to be on a site in the city which Russia occupied, officials say.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Putin-Xi talks: Russian leader reveals China’s ‘concern’ over Ukraine</strong> - But he also thanked President Xi for his “balanced position” on Russia’s invasion.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia’s Wagner boss: It’s prisoners fighting in Ukraine, or your children</strong> - The head of the Russian mercenary group defends sending convicts to the Ukraine front line.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Italy: Floods and rain kill at least ten overnight - officials</strong> - Rescuers are searching for four others missing after torrential rainfall hit the Marche region overnight.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Italy elections: ‘It’ll break my heart if energy costs shut my historic shop’</strong> - Italian businesses fear politicians are failing to address the cost of living crisis ahead of elections.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In a bid to expand its Moon business, Intuitive Machines will go public</strong> - “This really gives the financial resources to take the next steps.” - <a href="https://arstechnica.com/?p=1881707">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trojanized versions of PuTTY utility being used to spread backdoor</strong> - Threat actor has connections to hackers backed by North Korean government. - <a href="https://arstechnica.com/?p=1882005">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>HBO drops official trailer for Avenue 5’s second and final season</strong> - “I say we sit here and wait for death…. some combination of sitting and death.” - <a href="https://arstechnica.com/?p=1881746">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dangerously wrong oxygen readings in dark-skinned patients spur FDA scrutiny</strong> - The meeting follows years of mounting data on inaccuracies and potential harms. - <a href="https://arstechnica.com/?p=1881985">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Halo Infinite’s canceled split-screen campaign can be uncanceled by exploit</strong> - In-depth analysis has us wondering what is going on with <em>Halo</em>’s stewardship. - <a href="https://arstechnica.com/?p=1881804">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A couple are having sex in the cemetery. The woman has back problems and goes to the doctor.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The doctor asks, “Miss, how old are you?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I’m 27 years old. Why?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“No reason; it’s just that it says on your ass that you died in 1929.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/LadeeAlana"> /u/LadeeAlana </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/xfm86a/a_couple_are_having_sex_in_the_cemetery_the_woman/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/xfm86a/a_couple_are_having_sex_in_the_cemetery_the_woman/">[comments]</a></span></p></li>
<li><strong>Wife asks her husband to fix the fridge. He replies “What am I, a repairman?” So she got their neighbor to fix it. She tells her husb “It’s fixed. Our neighbor said he would fix it if I either slept with him or baked him a pie.”</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Husband laughs and asks “So what kind of pie did you bake him?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Wife replies “What am I, a baker?”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/yaykarin"> /u/yaykarin </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/xfavvv/wife_asks_her_husband_to_fix_the_fridge_he/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/xfavvv/wife_asks_her_husband_to_fix_the_fridge_he/">[comments]</a></span></p></li>
<li><strong>a bear walks into a bar and says, “give me a whiskey and… cola”</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“why the big pause?” Asks the bartender.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The bear shrugged. “I’m not sure; I was born with them.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/yomommafool"> /u/yomommafool </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/xeyyym/a_bear_walks_into_a_bar_and_says_give_me_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/xeyyym/a_bear_walks_into_a_bar_and_says_give_me_a/">[comments]</a></span></p></li>
<li><strong>If someone calls you fat, just ignore them.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
You are bigger than that!
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/DietCakes"> /u/DietCakes </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/xfggkl/if_someone_calls_you_fat_just_ignore_them/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/xfggkl/if_someone_calls_you_fat_just_ignore_them/">[comments]</a></span></p></li>
<li><strong>Why do koi fish travel in groups of four?</strong> - <!-- SC_OFF -->
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To protect the group from predators. When attacked, kois A, B, and C will go in one direction. The fourth one is the D koi.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/ZaBaronDV"> /u/ZaBaronDV </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/xf44t2/why_do_koi_fish_travel_in_groups_of_four/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/xf44t2/why_do_koi_fish_travel_in_groups_of_four/">[comments]</a></span></p></li>
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