++To confront the global Covid-19 pandemic and reduce the spread of the virus, we need to better understand if face mask use is effective to contain the outbreak and investigate the potential drivers in favor of mask adoption. It is highly questionable since there is no consensus among the general public despite official recommendations. For the first time, we conduct a panel econometric exercise to assess the dynamic impact of face mask use on both infected cases and fatalities on a global scale. We reveal a negative impact of mask wearing on fatality rates and on the Covid-19 number of infected cases. The delay of action varies from around 7 days to 28 days concerning infected cases but is more longer concerning fatalities. We also document the increasing adoption of mask use over time. We find that population density and pollution levels are significant determinants of heterogeneity regarding mask adoption across countries, while altruism, trust in government and demographics are not. Surprisingly, government effectiveness and income level (GDP) have an unexpected influence. However, strict government policies against Covid-19 have the most significant effect on mask use. Therefore, the most effective way of increasing the level of mask wearing is to enforce strict laws on the wearing of masks. +
++Background: The varied clinical manifestations and outcomes in patients with SARS-CoV-2 infections implicate a role of host-genetics in the predisposition to disease severity. This is supported by evidence that is now emerging, where initial reports identify common risk factors and rare genetic variants associated with high risk for severe/ life-threatening COVID-19. Impressive global efforts have focused on either identifying common genetic factors utilizing short-read sequencing data in Genome-Wide Association Studies (GWAS) or whole-exome and genome studies to interrogate the human genome at the level of detecting single nucleotide variants (SNVs) and short indels. However, these studies lack the sensitivity to accurately detect several classes of variants, especially large structural variants (SVs) including copy number variants (CNVs), which account for a substantial proportion of variation among individuals. Thus, we investigated the host genomes of individuals with severe/life-threatening COVID-19 at the level of large SVs (500bp-Mb level) to identify events that might provide insight into the inter-individual clinical variability in clinical course and outcomes of COVID-19 patients. Methods: Optical genome mapping using Bionano Saphyr system was performed on thirty-seven severely ill COVID-19 patients admitted to intensive care units (ICU). To extract candidate SVs, three distinct analyses were undertaken. First, an unbiased whole-genome analysis of SVs was performed to identify rare/unique genic SVs in these patients that did not appear in population datasets to determine candidate loci as decisive predisposing factors associated with severe COVID-19. Second, common SVs with a population frequency filter was interrogated for possible association with severe COVID-19 based on literature surveys. Third, genome-wide SV enrichment in severely ill patients versus the general population was investigated by calculating odds ratios to identify top-ranked genes/loci. Candidate SVs were confirmed using qPCR and an independent bioinformatics tool (FaNDOM). Results: Our patient-centric investigation identified 11 SVs involving 38 genes implicated in three key host-viral interaction pathways: (1) innate immunity and inflammatory response, (2) airway resistance to pathogens, and (3) viral replication, spread, and RNA editing. These included seven rare/unique SVs (not present in the control dataset), identified in 24.3% (9/37) of patients, impacting up to 31 genes, of which STK26 and DPP4 are the most promising candidates. A duplication partially overlapping STK26 was corroborated with data showing upregulation of this gene in severely ill patients. Further, using a population frequency filter of less than 20% in the Bionano control dataset, four SVs involving seven genes were identified in 56.7% (21/37) of patients. Conclusion: This study is the first to systematically assess and highlight SVs9 potential role in the pathogenesis of COVID-19 severity. The genes implicated here identify novel SVs, especially STK26, and extend previous reports involving innate immunity and type I interferon response in the pathogenesis of COVID-19. Our study also shows that optical genome mapping can be a powerful tool to identify large SVs impacting disease outcomes with split survival and add valuable genomic information to the existing sequencing-based technology databases to understand the inter-individual variability associated with SARS-CoV-2 infections and COVID-19 mortality. +
++Objectives: A proper description of the immune response to SARS-CoV-2 will be critical for the assessment of protection elicited after both infection and vaccination. Uncoupled T and B cell responses have been described in acute and convalescent patients and exposed individuals. We aimed to assess the potential usefulness of whole blood stimulation assays to identify functional cellular immune responses to SARS-CoV-2. Methods: Blood from COVID-19 recovered individuals (5 months after infection) and negative subjects was stimulated for 24 hours with HLA predicted peptide megapools of the Spike and Nucleoprotein, or the mixture of them. After stimulation, cytokines were quantified using a beads-based multiplex assay. Results: Interleukin-2 and IFN-γ were found to be specific biomarkers of SARS-CoV-2 cellular response. Using the Spike and Nucleoprotein mixture, 91.3% of COVID-19 recovered individuals presented an IL-2 stimulation index over the cut-off, while 82.6% showed IFN-γ. All the negative individuals presented an IL-2 response under the cut-off, while 5.3% of these subjects presented positive IFN-γ stimulation indexes. Moreover, IL-2 production correlated with IgG levels for Spike 1, RBD, and Nucleocapsid. Conclusion: We demonstrate the potential of whole blood stimulation assays and the quantification of IL-2 and IFN-γ for the analysis of SARS-CoV-2 functional cellular responses. +
++Congregate settings and high-density workplaces have endured a disproportionate impact from COVID-19. In order to provide further understanding of the transmission patterns of SARS-CoV-2 in these settings, whole genome sequencing (WGS) was performed on samples obtained from 8 selected outbreaks in Minnesota from March −June, 2020. WGS and phylogenetic analysis was conducted on 319 samples, constituting 14.4% of the 2,222 total SARS-CoV-2-positive individuals associated with these outbreaks. Among the sequenced specimens, three LTCFs and both correctional facilities had spread associated with a single genetic sequence. A fourth LTCF had outbreak cases associated with two distinct sequences. In contrast, cases associated with outbreaks in the two meat processing plants represented multiple SARS-CoV-2 sequences. These results suggest that a single introduction of SARS-CoV-2 into a facility can result in a widespread outbreak, and early identification and cohorting of cases, along with continued vigilance with infection prevention and control measures is imperative. +
++Background：Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), mainly transmitted by droplets and close contact, has caused a pandemic worldwide as of November 2020. According to the current case reports and cohort studies, the symptoms of pregnant women infected with SARS-CoV-2 were similar to normal adults and may cause a series of adverse consequences of pregnancy (placental abruption, fetal distress, epilepsy during pregnancy, etc.). However, whether SARS-CoV-2 can be transmitted to the fetus through the placental barrier is still a focus of debate. Methods：In this study, in order to find out whether SARS-CoV-2 infect fetus through placental barrier, we performed qualitative detection of virus structural protein (spike protein and nucleoprotein) and targeted receptor protein (ACE2, CD147 and GRP78) expression on the placental tissue of seven pregnant women diagnosed with COVID-19 through immunohistochemistry. Amniotic fluid, neonatal throat, anal swab and breastmilk samples were collected immediately in the operating room for verification after delivery, which were all tested for SARS-CoV-2 by reverse transcriptionpolymerase chain reaction (RT-PCR). Results: The result showed that CD147 was expressed on the basal side of the chorionic trophoblast cell membrane and ACE2 was expressed on the maternal side, while GRP78 was strongly expressed in the cell membrane and cytoplasm. The RT-PCR results of Amniotic fluid, neonatal throat, anal swab and breastmilk samples were all negative. Conclusions: We believed that despite the detection of viral structural proteins in the placenta, SARS-CoV-2 cannot be transmitted to infants due to the presence of the placental barrier. +
++One of the best ways to contain the spread of COVID-19 is frequent testing of as many people as possible and timely isolation of uninfected personnel from infected personnel. However, the cost of massive testing is affordable in many countries. The existing technologies might not be scalable to offer affordable testing for millions of people. To address this issue, novel testing methods based on Loop-Mediated Isothermal Amplification (LAMP) were proposed that are more sensitive, require less reagents and can work with saliva samples instead of more tedious nasal swabs. As a result, LAMP based protocols can make it possible to drive the cost down to one dollar per test. These LAMP based methods require a centrifuge device, mostly for separation of viral particles from reaction inhibitors in saliva samples. However, centrifuge is neither accessible nor affordable in many resource limited settings, especially during this pandemic situation when normal supply chains are heavily disrupted. To overcome these challenges, we invented a low-cost centrifuge that can be useful for carrying out low-cost LAMP based detection of SARS-Cov2 virus in saliva. The 3D printed centrifuge (Mobilefuge) is portable, robust, stable, safe, easy to build and operate. The Mobilefuge doesn9t require soldering or programming skills and can be built without any specialised equipment, yet practical enough for high throughput use. More importantly, Mobilefuge can be powered from widely available USB ports, including mobile phones and associated power supplies. This allows the Mobilefuge to be used even in off-grid and resource limited settings. We believe that our invention will aid the efforts to contain the spread of COVID-19 by lowering the costs of testing equipment. Apart from the COVID-19 testing, the Mobilefuge can have applications in the field of biomedical research and diagnostics. +
++Importance: A significant proportion of COVID-19 transmission occurs silently during the pre-symptomatic and asymptomatic stages of infection. Children, while being important drivers of silent transmission, are not included in COVID-19 vaccination campaigns given their exclusion from clinical trials thus far. Objective: To investigate the impact of a targeted approach to identifying silent infections among children as a proxy for their vaccination. Design: This study used an age-structured disease transmission model to simulate the synergistic impact of interventions in reducing attack rates over the course of one year. Setting: A synthetic population representative of the demographics of the United States (US). Participants: Six age groups of 0-4, 5-10, 11-18, 19-49, 50-64, 65+ years old, stratified for their population size based on US census data. Exposures: Vaccination of adults, self-isolation of all symptomatic cases within 24 hours of symptom onset, and detection of silent infections. Main Outcomes and Measures: Vaccination of adults was implemented to reach a 40% coverage over the course of one year with a vaccine efficacy of 95% against symptomatic and severe COVID-19. Without vaccination of children, we determined the proportion and speed that would be required for identifying silent infections among this age group to suppress future attack rates below 5%. Results: A targeted approach that identifies 20.6% and 28.6% of silent infections among children within 2 or 3 days post-infection, respectively, would be required to bring attack rates under 5% with vaccination of adults. If silent infections among children remained undetected, achieving the same attack rates would require an unrealistically high vaccination coverage (at least 82%) of this age group, in addition to the base-case 40% vaccination coverage of adults. The results were robust in sensitivity analyses with respect to vaccine efficacy against infection and reduced susceptibility of children to infection. Conclusions and Relevance: In the absence of vaccine availability for children, a targeted approach to rapid identification of silent COVID-19 infections in this age group can significantly mitigate disease burden. Without measures to interrupt transmission chains from silent infections, vaccination of adults is unlikely to contain the outbreaks in the near term. +
++Background: Recently, two "Coronavirus disease 2019" (COVID-19) vaccine products have been authorized in Canada. It is of crucial importance to model an integrated/combined package of non-pharmaceutical (physical/social distancing) and pharmaceutical (immunization) public health control measures. Methods: A modified epidemiological, compartmental SIR model was utilized and fit to the cumulative COVID-19 case data for the province of Ontario, Canada, from September 8, 2020 to December 8, 2020. Different vaccine roll-out strategies were simulated until 75 percent of the population is vaccinated, including a no-vaccination scenario. We compete these vaccination strategies with relaxation of non-pharmaceutical interventions. Non-pharmaceutical interventions were supposed to remain enforced and began to be relaxed on either January 31, March 31, or May 1, 2021. Results: Based on projections from the data and long-term extrapolation of scenarios, relaxing the public health measures implemented by re-opening too early would cause any benefits of vaccination to be lost by increasing case numbers, increasing the effective reproduction number above 1 and thus increasing the risk of localized outbreaks. If relaxation is, instead, delayed and 75 percent of the Ontarian population gets vaccinated by the end of the year, re-opening can occur with very little risk. Interpretation: Relaxing non-pharmaceutical interventions by re-opening and vaccine deployment is a careful balancing act. Our combination of model projections from data and simulation of different strategies and scenarios, can equip local public health decision- and policy-makers with projections concerning the COVID-19 epidemiological trend, helping them in the decision-making process. +
++We propose a deterministic model capturing essential features of contact tracing as part of public health non-pharmaceutical interventions to mitigate an outbreak of an infectious disease. By incorporating a mechanistic formulation of the processes at the individual level, we obtain an integral equation (delayed in calendar time and advanced in time since infection) for the probability that an infected individual is detected and isolated at any point in time. This is then coupled with a renewal equation for the total incidence to form a closed system describing the transmission dynamics involving contact tracing. We define and calculate basic and effective reproduction numbers in terms of pathogen characteristics and contact tracing implementation constraints. When applied to the case of SARS-CoV-2, our results show that only combinations of diagnosis of symptomatic infections and contact tracing that are almost perfect in terms of speed and coverage can attain control, unless additional measures to reduce overall community transmission are in place. Under constraints on the testing or tracing capacity, a temporary interruption of contact tracing may, depending on the overall growth rate and prevalence of the infection, lead to an irreversible loss of control even when the epidemic was previously contained. +
++[Objectives] In this study, a comparative study between primers from Japan9s and US9s disease control centers was conducted. As further investigation, virus sequence alignment with primers9 oligonucleotide was analyzed. [Design or methods] 11,652 samples from Japanese population were tested for SARS-CoV-2 positive using recommended RT-PCR primer-probe sets from Japan National Institute of Infectious Disease (NIID) and US Centers for Disease Control and Prevention (CDC). [Results] Of the 102 positive samples, 17 samples (16.7% of total positives) showed inconsistent results when tested simultaneously for the following primers: JPN-N2, JPN-N1, CDC-N1, and CDC-N2. As a result, CDC recommended primer-probe sets showed relatively higher sensitivity and accuracy. Further virus sequence alignment analysis showed evidences for virus mutation happening at primer9s binding sites. [Conclusions] The inconsistency in the RT-PCR results for JPN-N1, JPN-N2, CDC-N1, and CDC-N2 primer-probe sets could be attributed to differences in virus mutation at primers9 binding site as observed in sequence analysis. The use of JPN-N2 combined with CDC-N2 primer produces the most effective result to reduce false negatives in Japan region. In addition, adding CDC-N1 will also help to detect false negatives. +
+Dendritic Cell Vaccine to Prevent COVID-19 - Condition: COVID-19
Intervention: Biological: AV-COVID-19
Sponsors: Indonesia-MoH; Aivita Biomedical, Inc.; PT AIVITA Biomedika Indonesia; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia; RSUP Dr. Kariadi Semarang, indonesia; Faculty of Medicine University of Diponegoro, Indonesia
Recruiting
A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Adult - Condition: Covid19 Vaccine
Interventions: Biological: MVC-COV1901(S protein with adjuvant); Biological: MVC-COV1901(Saline)
Sponsor: Medigen Vaccine Biologics Corp.
Recruiting
Effect of Tenofovir/Emtricitabine in Patients Recently Infected With SARS-COV2 (Covid-19) Discharged Home - Condition: Covid19
Intervention: Drug: tenofovir disoproxil and emtricitabine
Sponsor: University Hospital, Caen
Recruiting
The Safety and Efficacy of Pyronaridine-artesunate (Pyramax® or Artecom®)in COVID-19 Patients - Condition: Covid19
Interventions: Drug: Artecom® (pyronaridine-artesunate); Drug: Placebo
Sponsor: Shin Poong Pharmaceutical Co. Ltd.
Not yet recruiting
Safety and Immunogenicity of Two Different Strengths of the Inactivated COVID-19 Vaccine ERUCOV-VAC - Condition: COVID-19 Vaccine
Interventions: Biological: ERUCOV-VAC; Other: Placebo Vaccine
Sponsors: Health Institutes of Turkey; TC Erciyes University
Recruiting
Efficacy of Ramdicivir and Baricitinib for the Treatment of Severe COVID 19 Patients - Conditions: Covid19; Covid-19 ARDS
Interventions: Drug: Remdesivir; Drug: Baricitinib; Drug: Tocilizumab
Sponsors: M Abdur Rahim Medical College and Hospital; First affiliated Hospital Xi'an Jiaoting University
Recruiting
The Effect of Deep Breathing Exercise on Dyspnea, Anxiety and Quality of Life in Patients Treated for COVID-19 - Condition: COVID-19
Intervention: Behavioral: Deep Breathing Exercise with Triflo
Sponsor: Ankara University
Not yet recruiting
Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19. - Condition: COVID-19
Interventions: Biological: AZD1222; Biological: rAd26-S
Sponsors: R-Pharm; AstraZeneca
Not yet recruiting
Surgical Face Mask Effects in Patients With COVID-19 - Condition: Covid19
Intervention: Other: Sit-To-Stand test
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Not yet recruiting
Efficacy of Favipiravir in Treatment of Mild & Moderate COVID-19 Infection in Nepal - Condition: Covid19
Interventions: Drug: Favipiravir; Drug: Placebo; Drug: Remdesivir
Sponsor: Nepal Health Research Council
Recruiting
Dendritic Cell Vaccine, AV-COVID-19, to Prevent COVID-19 Infection - Condition: COVID-19
Interventions: Biological: AV-COVID-19; Other: GM-CSF
Sponsors: Aivita Biomedical, Inc.; PT AIVITA Biomedika Indonesia; Indonesia Ministry of Health; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
Recruiting
A Real World Study of Bamlanivimab in Participants With Mild-to-moderate Coronavirus Disease 2019 (COVID-19) - Condition: COVID-19
Intervention: Drug: Bamlanivimab
Sponsors: Eli Lilly and Company; AbCellera Biologics Inc.
Not yet recruiting
Feasibility of Remote Evaluation and Monitoring of Acoustic Pathophysiological Signals With External Sensor Technology in Covid-19 - Condition: Covid19
Intervention: Device: Senti V1.0 Device
Sponsors: Senti Tech Ltd; Liverpool University Hospitals NHS Foundation Trust
Not yet recruiting
RescuE pLAsma eXchange in Severe COVID-19 - Conditions: Therapeutic Plasma Exchange; Covid19
Intervention: Other: Therapeutic plasma exchange
Sponsor: Heidelberg University
Recruiting
Can RIC Prevent Deterioration to Critical Care in Covid19 - Conditions: Covid19; Ischemia
Interventions: Procedure: Cuff application with inflation; Other: Sham inflation
Sponsor: Derek Yellon
Recruiting
COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice - Vaccines against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are urgently needed. We developed two COVID-19 vaccines based on modified vaccinia virus Ankara (MVA) vectors expressing the entire SARS-CoV-2 spike (S) protein (MVA-CoV2-S); their immunogenicity was evaluated in mice using DNA/MVA or MVA/MVA prime/boost immunizations. Both vaccines induced robust, broad and polyfunctional S-specific CD4+ (mainly Th1) and CD8+ T-cell responses, with a T effector memory phenotype. DNA/MVA...
'BhAVI-23'-A spice-herb based dietary infusion possessing in-vitro anti-viral potential - CONCLUSION: This 'BhAVI-23' infusion displayed prominent in-vitro anti-viral and anti-diabetic potential in different model systems. These attributes have relevance as diabetic patients are more prone to COVID-19 morbidity. 'BhAVI-23' opens the avenue for its potential inclusion as a supportive health care system upon due regulatory approval during the current pandemic.
Higher expression of monocyte chemotactic protein 1 in mild COVID-19 patients might be correlated with inhibition of Type I IFN signaling - CONCLUSION: Higher expression of MCP-1 in mild COVID-19 patients might be correlated with inhibition of IFN signaling. The finding adds to our understanding of the immunopathological mechanisms of severe acute respiratory syndrome coronavirus 2 infection and provides potential therapeutic targets and strategies.
Identification of potential SARS-CoV-2 M(pro) inhibitors integrating molecular docking and water thermodynamics - The COVID-19 pandemic is an ongoing global health emergency caused by a newly discovered coronavirus SARS-CoV-2. The entire scientific community across the globe is working diligently to tackle this unprecedented challenge. In silico studies have played a crucial role in the current situation by expediting the process of identification of novel potential chemotypes targeting the viral receptors. In this study, we have made efforts to identify molecules that can potentially inhibit the SARS-CoV-2...
Combination therapy of IFNbeta1 with lopinavir-ritonavir, increases oxygenation, survival and discharging of sever COVID-19 infected inpatients - Interferon Beta-1a (IFN-β1-a), an immunomodulatory mediator with antiviral effects, has shown in vivo and in vitro activities especially on coronavirus including SARS-CoV-2. COVID-19 defined as the disease caused by infection with SARS-CoV-2. The virus has been illustrated inhibits the production of IFN-β1-a from inflammatory cells. We conducted a retrospective study of all adult confirmed COVID-19 hospitalized patients who received combination of three doses of 12 million international units of...
Active vitamin D supplementation and COVID-19 infections: review - SARS-CoV-2, causing the lethal disease COVid-19, is a public health emergency in the 2020 global pandemic. The outbreak and fast spreading of SARS-CoV-2 have a high morbidity and mortality specifically in elder patients with chronic diseases such as diabetes mellitus, arterial hypertension, chronic kidney disease, and organ transplanted patients with immunosuppressive therapy. Preliminary results support different treatments such as chloroquine and convalescent plasma infusion in severe cases,...
A SARS-CoV-2 antiviral therapy score card - The COVID-19 pandemic has unleashed an unprecedented effort to identify efficacious treatments for persons infected with SARS-CoV-2. As of September 2020, more than 750 completed, ongoing, or planned clinical trials of drugs intended to inhibit SARS-CoV-2 replication have been registered on the ClinicalTrials.gov or WHO International Clinical Trials Platform websites. Most of the treatments studied in these trials are repurposed licensed or investigational drugs targeting viral proteins or...
Exploration of natural compounds with anti-SARS-CoV-2 activity via inhibition of SARS-CoV-2 Mpro - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a dreaded pandemic in lack of specific therapeutic agent. SARS-CoV-2 Mpro, an essential factor in viral pathogenesis, is recognized as a prospective therapeutic target in drug discovery against SARS-CoV-2. To tackle this pandemic, Food and Drug Administration-approved drugs are being screened against SARS-CoV-2 Mpro via in silico and in vitro methods to detect the best conceivable drug...
Kinins and Chymase: The Forgotten Components of the Renin angiotensin system and their implications in COVID-19 Disease - The unique clinical features of COVID-19 disease present a formidable challenge in the understanding of its pathogenesis. Within a very short time, our knowledge regarding basic physiologic pathways that participate in SARS CoV-2 invasion and subsequent organ damage have been dramatically expanded. In particular, we now better understand the complexity of the renin-angiotensin-aldosterone system (RAAS) and the important role of angiotensin converting enzyme (ACE)-2 in viral binding. Furthermore,...
Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients - COVID-19 caused by SARS-CoV-2, is an international concern. This infection requires urgent efforts to develop new antiviral compounds. To date, no specific drug in controlling this disease has been identified. Developing the new treatment is usually time consuming, therefore using the repurposing broad-spectrum antiviral drugs could be an effective strategy to respond immediately. In this review, a number of broad-spectrum antivirals with potential efficacy to inhibit the virus replication via...
Chloroquine and hydroxychloroquine provoke arrhythmias at concentrations higher than those clinically used to treat COVID-19. A simulation study - The risk of fatal arrhythmias is the major concern for using chloroquine (CQ) or hydroxychloroquine (HCQ) to treat coronavirus disease 2019 (COVID-19), but the reported number of life-threatening arrhythmic events or deaths is relatively small. The objective of this study was to assess the arrhythmogenic risk of these two drugs using a multi-scale heart simulation, which allows testing even at high concentrations, including those that cause fatal arrhythmias. We measured the inhibitory action of...
Compassionate use of Ruxolitinib in patients with SarsCov-2 infection not on mechanical ventilation. Short-term effects on inflammation and ventilation - Ruxolitinib is an anti-inflammatory drug that inhibits the Janus kinase-signal transducer (JAK-STAT) pathway on the surface of immune cells. The potential targeting of this pathway using JAK inhibitors is a promising approach in patients affected by COVID-19 disease. Ruxolitinib was provided as a compassionate use in patients consecutively admitted to our institution for Sars-CoV-2 infection. Inclusion criteria were oxygen saturation ≤ 92%, signs of interstitial pneumoniae, and no need of...
Beneficial Effects of Intermediate Dosage of Anticoagulation Treatment on the Prognosis of Hospitalized COVID-19 Patients: The ETHRA Study - CONCLUSION: Anticoagulation treatment (particularly intermediate dosage) appears to have positive impact on COVID-19 inpatients' prognosis by inhibiting both coagulation and inflammatory cascades.
Computational analysis of dynamic allostery and control in the SARS-CoV-2 main protease - The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has no publicly available vaccine or antiviral drugs at the time of writing. An attractive coronavirus drug target is the main protease (M^(pro), also known as 3CL^(pro)) because of its vital role in the viral cycle. A significant body of work has been focused on finding inhibitors which bind and block the active site of the main protease, but little has been done to address potential non-competitive inhibition, targeting regions...
Surface interactions and viability of coronaviruses - The recently emerged coronavirus pandemic (COVID-19) has become a worldwide threat affecting millions of people, causing respiratory system related problems that can end up with extremely serious consequences. As the infection rate rises significantly and this is followed by a dramatic increase in mortality, the whole world is struggling to accommodate change and is trying to adapt to new conditions. While a significant amount of effort is focused on developing a vaccine in order to make a...
Covid 19 - Chewing Gum - - link
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
抑制病毒受体ACE2的COVID-19防治药物及其应用 - 本发明提供了一种抑制病毒受体ACE2的COVID‑19防治药物及其应用。具体地说，本发明提供了中药鹅不食草在制备调节ACE2表达量的药物中的应用。本发明还提供了中药鹅不食草单独或与其它药物组合在制备COVID‑19防治药物中的应用。本发明发现鹅不食草能够使正常肺上皮细胞中ACE2的表达降低，从而降低新型冠状病毒(SARS‑CoV‑2)感染的风险，发挥预防SARS‑CoV‑2感染及治疗COVID‑19的作用。中药鹅不食草成本低，毒副作用小，疗效显著，为COVID‑19的治疗提供了新策略。 - link
"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link
제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - link
Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link
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Mundschutz bestehend aus einem Abdeckteil für den Mund- und gegebenenfalls den Nasenbereich des Gesichts und einem Bandteil mit mindestens einem Halteband, welches mit den Seiten des Abdeckteil verbunden ist und zur Befestigung des Mundschutzes dient, wobei das Halteband am seitlichen Ende des Abdeckteils fixiert ist und eine Schlaufe bildet, dadurch gekennzeichnet, dass an der Schlaufe des Haltebands ein Clip befestigt ist.
Trump and the G.O.P. Lost Georgia. Black Voters Won It - A final push from the President in Dalton, and the tale told by turnout. - link
Mob Rule in the Capitol - Five years after the Trump era began, a physical assault on America’s basic symbols of democracy feels both shocking and inevitable. - link
The World Shook as America Raged - Allies were shocked by the insurrection in the world’s most powerful democracy, while ISIS and Al Qaeda celebrated the chaos at the Capitol. - link
Democrats Take the Senate, and a Mob Storms the Capitol - One of the most tumultuous days in recent American history began with the Reverend Raphael Warnock winning his Senate race in Georgia, and ended with Joe Biden officially becoming President-elect. - link
How Social Media Made the Trump Insurrection a Reality - Facebook banned the President from its platform on Thursday, but the move was too little, too late. - link
++These officials are leaving the Trump administration after Wednesday’s storming of the Capitol. +
++Following the storming of the US Capitol by a pro-Trump mob on Wednesday, several top White House officials have resigned, with others reportedly considering whether or not to step down. +
++The extraordinary events, which left four people dead, led to reports that some senior administration officials were discussing the use of the 25th Amendment to remove President Donald Trump from power or resigning themselves. +
++By Thursday morning, it appeared some of the senior officials who were rumored to be considering resigning, such as National Security Adviser Robert O’Brien, will instead serve out the last two weeks of Trump’s term. O’Brien was reportedly persuaded by some of his colleagues to remain in his post. +
++While there is still a lot of uncertainty about how widespread any resignations will be, the White House has seen several staff members step down already: +
++“As someone who worked in the halls of Congress I was deeply disturbed by what I saw today,” Matthews said in a statement. “I’ll be stepping down from my role, effective immediately. Our nation needs a peaceful transfer of power.” +
++The president’s incitement of the riot also drew a rebuke from Congress, where the House and Senate reconvened to affirm President-elect Joe Biden’s victory over Trump in the 2020 election, and Democrats began openly discussing impeachment and the 25th Amendment. Sen. Mitt Romney (R-UT) said on the Senate floor: “What happened today was an insurrection incited by the president of the United States.” +
++Early Thursday morning, two months after Election Day and the day after blood had been spilled at the US Capitol, Trump appeared to commit to an orderly transition to the Biden administration. +
++“Even though I totally disagree with the outcome of the election, and the facts bear me out, nevertheless there will be an orderly transition on January 20th,” the president said in a statement. +
+
++He still won’t concede the election, even with his back against the wall. +
++President Donald Trump acknowledged that a new administration will soon be inaugurated in an apparent attempt to quell bipartisan demands for his removal from office following Wednesday’s violent insurrection at the US Capitol — but stopped short of conceding that he had lost the November election. +
++“Now, Congress has certified the results and a new administration will be inaugurated on January 20,” Trump said in a video address from the White House on Thursday. “My focus now turns to ensuring a smooth, orderly and seamless transition of power. This moment calls for healing and reconciliation.” +
++He did not mention President-elect Joe Biden directly. But his language was just vague enough that Republicans could interpret his speech as a concession, giving them reason to resist growing calls to impeach the president or invoke the 25th Amendment to remove him from office just days before Biden is inaugurated on January 20. +
++But hinting at some kind of political future, he also said that he wanted his supporters to know that “our incredible journey is only just beginning.” +
++ +— Donald J. Trump (@realDonaldTrump) January 8, 2021 ++
+A majority of Democrats in the House and a growing number of Republicans, including Rep. Adam Kinzinger of Illinois, have sought Trump’s removal from office after he incited his supporters to storm the Capitol on Wednesday, resulting in the deaths of at least four people and significant property damage. However, Vice President Mike Pence, whose support would be needed to invoke the 25th Amendment, reportedly opposes doing so, and some Republicans have said they would prefer to just wait out the last days of the Trump presidency. +
++Apparently recognizing his precarious political position, Trump — who has reportedly been mulling pardoning himself in the final days of his presidency — sought to distance himself from Wednesday’s events and downplay his attempts to undermine the election results. +
++He condemned the “violence, lawlessness and mayhem” that occurred at the Capitol and falsely claimed that he had immediately deployed the National Guard to secure the building. (Despite being quick to deploy the National Guard in the face of last year’s Black Lives Matter protests, CNN reported that he had initially resisted doing so, requiring that Pence intervene.) +
++“To those who engage in the acts of violence and destruction: You do not represent our country, and to those who broke the law, you will pay,” Trump said. +
++Though Trump did not repeat his baseless claims of widespread voter fraud on Thursday, he echoed Republican talking points about election security, which the party has invoked as justification for making it harder for people to vote. +
++“My only goal was to ensure the integrity of the vote,” he said. “In so doing, I was fighting to defend American democracy. I continue to strongly believe that we must reform our election laws to verify the identity and eligibility of all voters and to ensure faith and confidence in all future elections.” +
+
++The software firm has taken down President Trump’s online stores. +
++While Facebook and other social networks suspended President Donald Trump from their platforms in the wake of his support for a mob that stormed the US Capitol on Wednesday, another tech firm took a different tack on Thursday. Shopify shut down his online merch stores. +
++Shopify, the Canada-based tech company that makes popular software tools to help merchants run online stores, shuttered the Trump Organization’s TrumpStore.com on Thursday morning, as well as the e-commerce portion of the president’s election website. +
++“Shopify does not tolerate actions that incite violence,” a Shopify spokesperson said in a statement. “Based on recent events, we have determined that the actions by President Donald J. Trump violate our Acceptable Use Policy, which prohibits promotion or support of organizations, platforms or people that threaten or condone violence to further a cause. As a result, we have terminated stores affiliated with President Trump.” +
++The spokesperson did not immediately respond to requests for information about any other “affiliated” online stores that were taken down as a result. +
++Shopify’s decision targeting Trump followed those of several other large internet companies in the wake of the president’s call for supporters to rally against Joe Biden’s election victory, which devolved into an insurrection on Capitol Hill. Facebook, Twitter, Instagram, and YouTube all took steps to restrict Trump’s ability to use their platforms in the last 24 hours, with Mark Zuckerberg writing on Thursday that Facebook and Instagram had suspended the president’s accounts until at least Inauguration Day. +
++“We believe the risks of allowing the President to continue to use our service during this period are simply too great,” Zuckerberg wrote. “Therefore, we are extending the block we have placed on his Facebook and Instagram accounts indefinitely and for at least the next two weeks until the peaceful transition of power is complete.” +
++++I asked these guys if civil war was what they wanted. “Yes” they replied pic.twitter.com/BLopvJP6Ik +
+— Tess Owen (@misstessowen) January 6, 2021 +
+It’s unclear whether other e-commerce providers, such as Amazon, Etsy, or eBay, will remove any Trump merchandise or Trump-affiliated sellers from their online marketplaces. On Thursday afternoon, shirts adorned with the phrase “MAGA Civil War,” which was seen on apparel worn by some rioters in DC on Wednesday, were available for sale on eBay. By Thursday evening, one of the shirts still appeared in eBay’s search results, but the listing had been deactivated. +
++“At eBay, we have a strict policy against hate and discrimination to ensure our platform remains a safe, trusted and inclusive environment for our global community of buyers and sellers,” a spokesperson told Recode. “While we are not removing politically affiliated merchandise from the site, we will remove any merchandise glorifying the violence incited on Capitol Hill.” +
++Update, January 7, 8:10 pm ET: This story was updated to include a statement and update from eBay. +
+BCCI decides to part ways with IMG - The BCCI has decided to part ways with International Management Group (IMG), which has held the events rights of the IPL since its inception, a top
I can rewind and play this Smith run-out, my best ever: Ravindra Jadeja - Ravindra Jadeja bowled brilliantly and returned with the figures of 4 for 62.
Aus vs Ind third Test | Being faster on feet, putting concerted pressure on Ashwin worked, says Steve Smith - Smith also said that he did not change his technique against the fast bowlers but was “just being faster on his feet particularly against the spin”.
Senior IOC member says he's not sure Tokyo Games will happen - A senior member of the International Olympic Committee has said he “can't be certain” the postponed Tokyo Olympics will open in just over six months
Aus vs Ind 4th Test: New three-day lockdown in Brisbane City puts final match under fresh cloud - The lockdown announcement came less than 24 hours after BCCI formally wrote to CA on relaxation of Brisbane hard quarantine.
Two-day music festival from today - Vocalists Pt. Venkatesh Kumar and Arati Anklikar will be paying musical tribute during the two-day music festival organised as part of the 66th death
Maratha quota issue | Maharashtra Minister Ashok Chavan seeks bigger Bench - Mr. Chavan, who heads a sub-committee of the State Cabinet on the issue, said the landmark Indira Sawhney case of 1993 was heard by a nine-member Bench.
Act against squatters on govt. housing: NHRC to Odisha - State owed ₹4 cr from retired employees, ex-MLAs refusing to vacate quarters
First case of infection of U.K. strain of coronavirus found in Madhya Pradesh - The patient, who is asymptomatic, has been placed in home isolation, Indore district collector Manish Singh said.
Watch | 2020: Indian bird-watchers' paradise - A video on the bird watching highlights of the year 2020
Covid: WHO urges tougher measures to curb 'alarming' variant - An official says 22 European countries have cases of the variant and tougher measures are needed.
Brexit: Firms warn of problems as new EU trade rules kick in - Firms warn of more red tape, higher costs and delays a week after new Brexit export rules took effect.
Covid-19: Travellers to UK will need to show negative test result - International travellers will have to take a Covid test up to 72 hours before departing.
Climate change: 2020 in a dead heat for world's warmest year - Satellite data shows that 2020 and 2016 are essentially tied as the hottest years since records began.
US backs down from tariffs over French tech giant taxes - The decision comes less than three weeks before US President Donald Trump is due to leave office.
Hackers can clone Google Titan 2FA keys using a side channel in NXP chips - Yubico and Feitian keys that use the same chip are likely susceptible, too. - link
Rocket Report: NASA ready to hot fire SLS, Roscosmos sues itself? - "We are obliged to file a lawsuit in connection with the satellite's failure." - link
Bummed about new Google Photos storage limits? Amazon Photos says “hi” - This surprisingly good photo service has flown mostly under the radar since 2014. - link
“Baby-making machines”: Chinese tweet on Uygurs not against Twitter rules - Twitter bans "the dehumanization of a group of people" based on ethnicity. - link
Anthony Mackie plays an android supersoldier in Outside the Wire trailer - Mikael Håfström directs this latest Netflix foray into action feature films. - link
+One does not simply walk into Mordor +
+ submitted by /u/mertcanhekim
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+Now when I talk I have this weird axe scent. +
+ submitted by /u/Bangbusta
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+Donald Trump's tie. +
+ submitted by /u/Jokeminder42
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+Good, he said. Take these drinks to table nine. +
+ submitted by /u/Bjarki56
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+(not my joke, the credit should go to u/modesty_blaise0 on twitter) +
+ submitted by /u/InvictusVictorious
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