diff --git a/archive-covid-19/03 June, 2023.html b/archive-covid-19/03 June, 2023.html new file mode 100644 index 0000000..82e90bc --- /dev/null +++ b/archive-covid-19/03 June, 2023.html @@ -0,0 +1,180 @@ + +
+ + + ++The transmission risk of SARS-CoV-2 within hospitals can exceed that in the general community because of more frequent close proximity interactions. However, epidemic risk across wards is still poorly described. We measured CPIs directly using wearable sensors given to all those present in a clinical ward over a 36-hour period, across 15 wards in three hospitals in spring 2020. Data were collected from 2114 participants. These data were combined with a simple transmission model describing the arrival of a single index case to the ward to estimate the risk of an outbreak. Estimated epidemic risk ranged four-fold, from 0.12 secondary infections per day in an adult emergency to 0.49 per day in general paediatrics. The risk presented by an index case in a patient varied twenty-fold across wards. Using simulation, we assessed the potential impact on outbreak risk of targeting the most connected individuals for prevention. We found that targeting those with the highest cumulative contact hours was most impactful (20% reduction for 5% of the population targeted), and on average resources were better spent targeting patients. This study reveals patterns of interactions between individuals in hospital during a pandemic and opens new routes for research into airborne nosocomial risk. +
++Background: Vaccination is an effective strategy to reduce morbidity and mortality from coronavirus disease 2019 (COVID-19). However, the uptake of COVID-19 vaccination has varied across and within countries. Switzerland has had lower levels of COVID-19 vaccination uptake in the general population than many other high-income countries. Understanding the socio-demographic factors associated with vaccination uptake can help to inform future vaccination strategies to increase uptake. Methods: We conducted a longitudinal online survey in the Swiss population, consisting of six survey waves from June to September 2021. Participants provided information on socio-demographic characteristics, history of testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), social contacts, willingness to be vaccinated, and vaccination status. We used a multivariable Poisson regression model to estimate the adjusted rate ratio (aRR) and 95% confidence intervals (CI) of COVID-19 vaccine uptake. Results: We recorded 6,758 observations from 1,884 adults. For the regression analysis, we included 3,513 observations from 1,883 participants. By September 2021, 600 (75%) of 806 study participants had received at least one vaccine dose. Participants who were older, male, and students, had a higher educational level, household income, and number of social contacts, and lived in a household with a medically vulnerable person were more likely to have received at least one vaccine dose. Female participants, those who lived in rural areas and smaller households, and people who perceived COVID-19 measures as being too strict were less likely to be vaccinated. We found no significant association between previous SARS-CoV-2 infections and vaccination uptake. Conclusions: Our results suggest that socio-demographic factors as well as individual behaviours and attitudes played an important role in COVID-19 vaccination uptake in Switzerland. Therefore, appropriate communication with the public is needed to ensure that public health interventions are accepted and implemented by the population. Tailored COVID-19 vaccination strategies in Switzerland that aim to improve uptake should target specific subgroups such as women, people from rural areas or people with lower socio-demographic status. Keywords: Vaccine, COVID-19, contact survey, social contact, socio-demographic characteristics, Switzerland. +
++Background: Social determinants of health are non-medical factors that influence health outcomes (SDOH). There is a wealth of SDOH information available via electronic health records, clinical reports, and social media, usually in free text format, which poses a significant challenge and necessitates the use of natural language processing (NLP) techniques to extract key information. Objective: The objective of this research is to advance the automatic extraction of SDOH from clinical texts. Setting and Data: The case reports of COVID-19 patients from the published literature are curated to create a corpus. A portion of the data is annotated by experts to create gold labels, and active learning is used for corpus re-annotation. Methods: A named entity recognition (NER) framework is developed and tested to extract SDOH along with a few prominent clinical entities (diseases, treatments, diagnosis) from the free texts. Results: The proposed NER implementation achieves an accuracy (F1-score) of 92.98% on our test set and generalizes well on benchmark data. A careful analysis of case examples demonstrates the superiority of the proposed approach in correctly classifying the named entities. Conclusions: NLP can be used to extract key information, such as SDOH from free texts. A more accurate understanding of SDOH is needed to further improve healthcare outcomes. +
++Wastewater, which contains everything from pathogens to pollutants, is a geospatially- and temporally-linked microbial fingerprint of a given population. As a result, it can be leveraged for monitoring multiple dimensions of public health across locales and time. Here, we integrate targeted and bulk RNA sequencing (n=1,419 samples) to track the viral, bacterial, and functional content over geospatially distinct areas within Miami Dade County from 2020-2022. First, we used targeted amplicon sequencing (n=966) to track diverse SARS-CoV-2 variants across space and time, and we found a tight correspondence with clinical caseloads from University students (N = 1,503) and Miami-Dade County hospital patients (N = 3,939 patients), as well as an 8-day earlier detection of the Delta variant in wastewater vs. in patients. Additionally, in 453 metatranscriptomic samples, we demonstrate that different wastewater sampling locations have clinically and public-health-relevant microbiota that vary as a function of the size of the human population they represent. Through assembly, alignment-based, and phylogenetic approaches, we also detect multiple clinically important viruses (e.g., norovirus) and describe geospatial and temporal variation in microbial functional genes that indicate the presence of pollutants. Moreover, we found distinct profiles of antimicrobial resistance (AMR) genes and virulence factors across campus buildings, dorms, and hospitals, with hospital wastewater containing a significant increase in AMR abundance. Overall, this effort lays the groundwork for systematic characterization of wastewater to improve public health decision making and a broad platform to detect emerging pathogens. +
+Extracorporeal Photopheresis as a Possible Therapeutic Approach to Adults With Severe and Critical COVID-19 - Condition: COVID-19
Intervention: Procedure: Extracorporeal photopheresis
Sponsor: Del-Pest Central Hospital - National Institute of Hematology and Infectious Diseases
Recruiting
A Clinical Trial on Booster Immunization of Two COVID-19 Vaccines Constructed From Different Technical Routes - Condition: COVID-19
Interventions: Biological: Prototype and Omicron BA.4/5 Bivalent Recombinant COVID-19 Vaccine(Adenovirus Type 5 Vector) For Inhalation; Biological: Bivalent COVID-19 mRNA Vaccine; Biological: Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) For Inhalation
Sponsors: Zhongnan Hospital; Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China
Recruiting
The Effect of Special Discharge Training in the COVID-19 - Condition: COVID-19 Pneumonia
Intervention: Other: COVID-19 Discharge Education
Sponsor: Kilis 7 Aralik University
Completed
Evaluation of Safety, Tolerability, Reactogenicity, Immunogenicity of Baiya SARS-CoV-2 Vax 2 as a Booster for COVID-19 - Conditions: COVID-19 Vaccine; COVID-19
Interventions: Biological: 50 μg Baiya SARS-CoV-2 Vax 2; Other: Placebo
Sponsor: Baiya Phytopharm Co., Ltd.
Not yet recruiting
Physiotherapy in Mutated COVID-19 Patients - Condition: COVID-19 Pandemic
Intervention: Behavioral: Physiotherapy
Sponsor: Giresun University
Completed
Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19 - Conditions: SARS-CoV Infection; COVID-19
Interventions: Drug: Mitoquinone/mitoquinol mesylate; Other: Placebo
Sponsor: University of Texas Southwestern Medical Center
Not yet recruiting
To Explore the Regulatory Effect of Combined Capsule FMT on the Levels of Inflammatory Factors in Peripheral Blood of Patients With COVID-19 During Treatment. - Conditions: Fecal Microbiota Transplantation; COVID-19 Infection
Intervention: Procedure: Fecal microbiota transplantation
Sponsor: Shanghai 10th People’s Hospital
Completed
Phase 3 Study of Novavax Vaccine(s) as Booster Dose After mRNA Vaccines - Condition: COVID-19
Interventions: Biological: NVX-CoV2373; Biological: SARS-CoV-2 rS antigen/Matrix-M Adjuvant
Sponsor: Novavax
Active, not recruiting
A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883. - Condition: COVID-19
Intervention: Drug: PF-07817883
Sponsor: Pfizer
Not yet recruiting
Dose Exploration Intramuscular/Intravenous Prophylaxis Pharmacokinetic Exposure Response Study - Condition: COVID-19
Interventions: Drug: AZD3152; Other: Placebo
Sponsor: AstraZeneca
Recruiting
Study to Assess Safety, Reactogenicity and Immunogenicity of the repRNA(QTP104) Vaccine Against SARS-CoV-2(COVID-19) - Conditions: COVID-19; SARS-CoV-2
Interventions: Biological: QTP104 1ug; Biological: QTP104 5ug; Biological: QTP104 25ug
Sponsor: Quratis Inc.
Active, not recruiting
Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19) - Conditions: Long COVID; Post-Acute Sequela of COVID-19; Post-Acute COVID-19
Interventions: Drug: AER002; Other: Placebo
Sponsors: Michael Peluso, MD; Aerium Therapeutics
Not yet recruiting
COVID Frequent Antigen Testing - Condition: COVID-19 Respiratory Infection
Intervention: Diagnostic Test: SARS CoV-2 antigen tests
Sponsors: IDX20 Inc; National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting
Effects of Individual Tailored Physical Exercise in Patients With POTS After COVID-19 - a Randomized Controlled Study - Conditions: Postural Orthostatic Tachycardia Syndrome; COVID-19; Post COVID-19 Condition; Post-Acute COVID-19 Syndrome
Intervention: Other: Individual tailored exercise
Sponsors: Karolinska Institutet; Karolinska University Hospital
Enrolling by invitation
Fluvoxamine for Long COVID-19 - Condition: Long COVID
Intervention: Drug: Fluvoxamine
Sponsors: Washington University School of Medicine; Balvi COVID Fund
Recruiting
Isolation of Anti-SARS-CoV-2 Natural Products Extracted from Mentha canadensis and the Semi-synthesis of Antiviral Derivatives - Traditional herbal medicine offers opportunities to discover novel therapeutics against SARS-CoV-2 mutation. The dried aerial part of mint (Mentha canadensis L.) was chosen for bioactivity-guided extraction. Seven constituents were isolated and characterized by nuclear magnetic resonance (NMR) and mass spectrometry (MS). Syringic acid and methyl rosmarinate were evaluated in drug combination treatment. Ten amide derivatives of methyl rosmarinate were synthesized, and the dodecyl (13) and…
Computational design of medicinal compounds to inhibit RBD-hACE2 interaction in the Omicron variant: unveiling a vulnerable target site - The COVID-19 pandemic, caused by SARS-CoV-2, has globally affected both human health and economy. Several variants with a high potential for reinfection and the ability to evade immunity were detected shortly after the initial reported case of COVID-19. A total of 30 mutations in the spike protein (S) have been reported in the SARS-CoV-2 (BA.2) variant in India and South Africa, while half of these mutations are in the receptor-binding domain and have spread rapidly throughout the world. Drug…
In silico screening, ADMET analysis and MD simulations of phytochemicals of Onosma bracteata Wall. as SARS CoV-2 inhibitors - Being attracted with their cardiotonic, antidiabetic, cough relieving activity, treatment of fever, absorbent, anti-asthmatic, etc. activities reported in ancient Ayurvedic literature, phytochemicals of Onosma bracteata wall should be evaluated for their activity against SARS-CoV-2 virus. The main objective of this study is to identify a hit molecule for the inhibition of entry, replication, and protein synthesis of SARS CoV-2 virus into the host. To achieve given objective, computational…
In silico Antivirus Repurposing and its Modification to Organoselenium Compounds as SARS-CoV-2 Spike Inhibitors - <b>Background and Objective:</b> The COVID-19, which has been circulating since late 2019, is caused by SARS-CoV-2. Because of its high infectivity, this virus has spread widely throughout the world. Spike glycoprotein is one of the proteins found in SARS-CoV-2. Spike glycoproteins directly affect infection by forming ACE-2 receptors on host cells. Inhibiting glycoprotein spikes could be one method of treating COVID-19. In this study, the antivirus marketed as a database will be…
PACT inhibits the replication of SARS-CoV-2 through the blockage of GSK-3β-N-nsp3 cascade - The protein activator of protein kinase R (PKR) (PACT) has been shown to play a crucial role in stimulating the host antiviral response through the activation of PKR, retinoic acid-inducible gene I, and melanoma differentiation-associated protein 5. Whether PACT can inhibit viral replication independent of known mechanisms is still unrevealed. In this study, we show that, like many viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks GSK-3β to facilitate its replication….
Evaluation of SARS-CoV-2 isolation in cell culture from nasal/nasopharyngeal swabs or saliva specimens of patients with COVID-19 - It has been revealed that SARS-CoV-2 can be efficiently isolated from clinical specimens such as nasal/nasopharyngeal swabs or saliva in cultured cells. In this study, we examined the efficiency of viral isolation including SARS-CoV-2 mutant strains between nasal/nasopharyngeal swab or saliva specimens. Furthermore, we also examined the comparison of viral isolation rates by sample species using simulated specimens for COVID-19. As a result, it was found that the isolation efficiency of…
A Facile Strategy to Construct Anti-Swelling, Antibacterial and Antifogging Coatings for Protection of Medical Goggles - During the COVID-19 pandemic, traditional medical goggles are not only easy to attach bacteria and viruses in long-term exposure, but also easy to fogged up, which increases the risk of infection and affects productivity. Bacterial adhesion and fog can be significantly inhibited through the hydrogel coatings, owing to their super hydrophilic properties. But on the one hand, hydrophilic hydrogel coatings are easy to absorb water and swell in wet environment, resulting in reduced mechanical…
Secreted ORF8 induces monocytic pro-inflammatory cytokines through NLRP3 pathways in patients with severe COVID-19 - Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe COVID-19 remains unidentified. Herein we demonstrate that the virus-encoded Open Reading Frame 8 (ORF8) protein is abundantly secreted as a glycoprotein in vitro and in symptomatic patients with COVID-19. ORF8 specifically binds to the NOD-like receptor family pyrin domain-containing 3 (NLRP3) in CD14^(+) monocytes to…
Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex - To facilitate selfish replication, viruses halt host gene expression in various ways. The nuclear export of mRNA is one such process targeted by many viruses. SARS-CoV-2, the etiological agent of severe acute respiratory syndrome, also prevents mRNA nuclear export. In this study, Nsp14, a bifunctional viral replicase subunit, was identified as a novel inhibitor of mRNA nuclear export. Nsp14 induces poly(A)+ RNA nuclear accumulation and the dissolution/coalescence of nuclear speckles. Genome-wide…
In Silico Screening of Drugs That Target Different Forms of E Protein for Potential Treatment of COVID-19 - Recently the E protein of SARS-CoV-2 has become a very important target in the potential treatment of COVID-19 since it is known to regulate different stages of the viral cycle. There is biochemical evidence that E protein exists in two forms, as monomer and homopentamer. An in silico screening analysis was carried out employing 5852 ligands (from Zinc databases), and performing an ADMET analysis, remaining a set of 2155 compounds. Furthermore, docking analysis was performed on specific sites…
Combination Therapy for the Treatment of Shingles with an Immunostimulatory Vaccine Virus and Acyclovir - Practically the entire global population is infected by herpesviruses that establish lifelong latency and can be reactivated. Alpha-herpesviruses, herpes simplex viruses 1 and 2 (HSV-1/HSV-2) and varicella zoster virus (VZV), establish latency in sensory neurons and then reactivate to infect epithelial cells in the mucosa or skin, resulting in a vesicular rash. Licensed antivirals inhibit virus replication, but do not affect latency. On reactivation, VZV causes herpes zoster, also known as…
Discovery of Polyphenolic Natural Products as SARS-CoV-2 Mpro Inhibitors for COVID-19 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down polyproteins synthesized from the viral RNA, making it a validated target for the development of SARS-CoV-2 therapeutics. New chemical phenotypes are frequently discovered in natural goods. In the current study, we used a fluorogenic assay to test a…
Neutralizing antibody levels and epidemiological information of patients with breakthrough COVID-19 infection in Toyama, Japan - Breakthrough infection (BI) after coronavirus disease 2019 (COVID-19) vaccination has exploded owing to the emergence of various SARS-CoV-2 variants and has become a major problem at present. In this study, we analyzed the epidemiological information and possession status of neutralizing antibodies in patients with BI using SARS-CoV-2 pseudotyped viruses (SARS-CoV-2pv). Analysis of 44 specimens diagnosed with COVID-19 after two or more vaccinations showed high inhibition of infection by 90% or…
Circulating ACE2 level and zinc/albumin ratio as potential biomarkers for a precision medicine approach to COVID-19 - Highly mutable influenza is successfully countered based on individual susceptibility and similar precision-like medicine approach should be effective against SARS-COV-2. Among predictive markers to bring precision medicine to COVID-19, circulating ACE2 has potential features being upregulated in both severe COVID-19 and predisposing comorbidities. Spike SARS-CoVs were shown to induce ADAM17-mediated shedding of enzymatic active ACE2, thus accounting for its increased activity that has also been…
Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro) - The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a great threat to public health while various vaccines are available worldwide. Main protease (M^(pro)) has been validated as an effective anti-COVID-19 drug target. Using medicinal chemistry and rational drug design strategies, we identified a quinazolin-4-one series of nonpeptidic, noncovalent SARS-CoV-2 M^(pro) inhibitors based on baicalein, 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one. In particular, compound C7 exhibits superior…
The Irrational Exuberance of a Non-Catastrophe - The bipartisan debt deal was a win for both Biden and McCarthy, but it might not have been the breakthrough Washington was waiting for. - link
The Abortion Fight Has Voters Turning to Ballot Initiatives - And Republicans are increasingly attempting to limit that direct-democracy option. - link
A Confession Exposes India’s Secret Hacking Industry - The country has developed a lucrative specialty: cyberattacks for hire. - link
Should We, and Can We, Put the Brakes on Artificial Intelligence? - Sam Altman, who ushered in ChatGPT, and Yoshua Bengio, an early pioneer of A.I., discuss the growing concerns surrounding unfettered, nonhuman intelligence. - link
Ted Koppel on Covering—and Befriending—Henry Kissinger - Did the veteran newscaster give Kissinger a pass on his hundredth birthday? - link
+Google, Adobe, Microsoft, and other tech companies are trying new ways to label content made by AI. +
++On May 22, a fake photo of an explosion at the Pentagon caused chaos online. +
++Within a matter of minutes of being posted, the realistic-looking image spread on Twitter and other social media networks after being retweeted by some popular accounts. Reporters asked government officials all the way up to the White House press office what was going on. +
++The photo was quickly determined to be a hoax, likely generated by AI. But in the short amount of time it circulated, the fake image had a real impact and even briefly moved financial markets. +
++This isn’t an entirely new problem. Online misinformation has existed since the dawn of the internet, and crudely photoshopped images fooled people long before generative AI became mainstream. But recently, tools like ChatGPT, DALL-E, Midjourney, and even new AI feature updates to Photoshop have supercharged the issue by making it easier and cheaper to create hyperrealistic fake images, video, and text, at scale. Experts say we can expect to see more fake images like the Pentagon one, especially when they can cause political disruption. +
++One report by Europol, the European Union’s law enforcement agency, predicted that as much as 90 percent of content on the internet could be created or edited by AI by 2026. Already, spammy news sites seemingly generated entirely by AI are popping up. The anti-misinformation platform NewsGuard started tracking such sites and found nearly three times as many as they did a few weeks prior. +
++“We already saw what happened in 2016 when we had the first election with a flooding of disinformation,” said Joshua Tucker, a professor and co-director of NYU’s Center for Social Media and Politics. “Now we’re going to see the other end of this equation.” +
++So what, if anything, should the tech companies that are rapidly developing AI be doing to prevent their tools from being used to bombard the internet with hyperrealistic misinformation? +
++One novel approach — that some experts say could actually work — is to use metadata, watermarks, and other technical systems to distinguish fake from real. Companies like Google, Adobe, and Microsoft are all supporting some form of labeling of AI in their products. Google, for example, said at its recent I/O conference that, in the coming months, it will attach a written disclosure, similar to a copyright notice, underneath AI-generated results on Google Images. OpenAI’s popular image generation technology DALL-E already adds a colorful stripe watermark to the bottom of all images it creates. +
++“We all have a fundamental right to establish a common objective reality,” said Andy Parsons, senior director of Adobe’s content authenticity initiative group. “And that starts with knowing what something is and, in cases where it makes sense, who made it or where it came from.” +
++In order to reduce confusion between fake and real images, the content authenticity initiative group developed a tool Adobe is now using called content credentials that tracks when images are edited by AI. The company describes it as a nutrition label: information for digital content that stays with the file wherever it’s published or stored. For example, Photoshop’s latest feature, Generative Fill, uses AI to quickly create new content in an existing image, and content credentials can keep track of those changes. +
++AI-labeling tools like Adobe’s are still in their early stages, and by no means should they be considered a silver bullet to the problem of misinformation. It’s technically possible to manipulate a watermark or metadata. Plus, not every AI generation system will want to disclose that it’s made that way. And as we’ve learned with the rise of online conspiracy theories in recent years, people will often ignore facts in favor of believing falsehoods that confirm their personal beliefs. But if implemented well — and especially if these labels are seen as more neutral than traditional social media fact-checking — AI disclosures could be one of our only hopes for navigating the increasingly blurry distinction between fake and real media online. +
++Here is how some of these early AI markup systems could work, what the limitations are, and what users can do to navigate our confusing post-truth internet reality in the meantime. +
++When you look at an image on social media or a search engine today, odds are you don’t know where the photo came from — let alone if it was created by AI. But underneath the hood, there’s often a form of metadata, or information associated with the digital image file, that tells you basic details, like when and where the photo was taken. Some tech companies are now starting to add specific metadata about AI to their products at the moment of creation, and they’re making that information more public in an effort to help users determine the authenticity of what they’re looking at. +
++Google recently said it will start marking up images made by its own new AI systems in the original image files. And when you see an image in Google Search that’s made by Google’s AI systems, it will say something like “AI-generated with Google” underneath the image. Going a step further, the company announced it’s partnering with publishers like Midjourney and stock photography site Shutterstock to let them self-tag their images as AI-generated in Google Search. This way, if you come across a Midjourney image in Google Search, it will say something like “Image self-labeled as AI-generated” +
+ ++Google Search public liaison Danny Sullivan said that this kind of AI labeling is part of a broader effort to give people more context about images they’re seeing. +
++”If we can show you a helpful label, we’re going to want to do that,” said Sullivan, “but we’re also going to want to try to give you background information that we can determine independent of the label.” +
+ ++That’s why Google is also adding an “About this image” feature next to image search results — whether they are AI labeled or not — that you can click and see when the image was first indexed by Google, where it may have first appeared, and where else it’s been seen online. The idea is, if you searched for, say, “Pentagon explosion” and saw a bunch of images in the results, you would be able to see a fact-checked news article debunking the piece. +
++“These tools are really designed to help people understand information literacy more and bake it into the search product itself,” said Sullivan. +
++Other major industry players have also been working on the issue of how to label AI-generated content. In 2021, a group of major companies including Microsoft, Adobe, the BBC, and Intel created a coalition called the C2PA. The group is tasked with helping to create an interoperable open standard for companies to share the provenance, or history of ownership, of a piece of media. C2PA created its first open standard last January, and since then, Adobe and Microsoft have released features using that standard. +
++For example, if you’re a photographer at a news outlet, you can mark when a specific picture was taken, who took it, and have that be digitally signed by your publisher. Later, your editor could make changes to the photo, signing it again with a seal of authenticity that it’s been verified by the C2PA standard. This way, you know that the photo was taken by a person — not generated by AI— and know who has made edits to it and when. The system uses cryptography to preserve the privacy of sensitive information. +
++“Now you can read the entire lineage of the history of a piece of digital content,” said Mounir Ibrahim, EVP of public affairs and impact at Truepic, a visual authenticity app that is a member of C2PA. “The purpose of us is to help content consumers … decipher the difference between synthetic and authentic.” +
++Knowing the history and provenance of an image could potentially help users verify the legitimacy of anything from a headshot on a dating app to a breaking news photo. But for this to work, companies need to adopt the standard. +
++Right now, it’s up to companies to adopt the C2PA standard and label verified content as they wish. The organization is also discussing potentially standardizing the look of the C2PA content credential when it shows up on images, Ibrahim said. In the future, the C2PA credential could be similar to the little padlock icon next to the URL in your browser window that signifies your connection is secure. When you see the proposed C2PA icon, you would know that the image you’re seeing has had its origins verified. +
++So far, two big C2PA members, Adobe and Microsoft, have announced tools that integrate C2PA standards into their products to mark up AI-generated content. Microsoft is labeling all AI-generated content in Bing Image Generator and Microsoft Designer, and Adobe is using C2PA standards in its new AI Firefly product’s content credentials. +
++“The biggest challenge is we need more platforms to adopt this,” said Ibrahim. +
++While the C2PA-style metadata labels work behind the scenes, another approach is for AI systems to add visible watermarks, as OpenAI has done with the rainbow bar at the bottom of DALL-E images. The company says it’s also working on a version of watermarking for its text app, ChatGPT. The challenge with watermarks, though, is that they can be removed. A quick Google search turns up forms of people discussing how to circumvent the imprint. +
++Another imperfect option is technology that can detect AI-generated content after the fact. In January, OpenAI released a tool that lets you cross-check a block of text to determine whether it’s likely written by AI. The problem, though, is that by OpenAI’s own assessment, the tool is not fully reliable. It correctly identified only 26 percent of AI-written texts in OpenAI’s evaluations, although it’s notably more accurate with longer than shorter text. +
++“We don’t want any of our models to be used for misleading purposes anywhere,” said a spokesperson for OpenAI in a statement. “Our usage policies also require automated systems, including conversational AI and chatbots, to disclose to users that they are interacting with our models.” +
++At the end of the day, even if these early AI flagging and identification systems are flawed, they’re a first step. +
++It’s still early days for tech platforms trying to automate the identification of AI-generated content. Until they identify a dependable solution, however, fact-checkers are left manually filling in the gaps, debunking images like the Pope in a puffy jacket or fake audio of politicians. +
++Sam Gregory, executive director of human rights and civic journalism network Witness, who works with fact-checkers largely outside of the US, said that while he thinks technical solutions to AI identification like watermarking are promising, many fact-checkers are worried about the onslaught of misinformation that could come their way with AI in the meantime. Already, many professional fact-checkers are dealing with far more content to check than humanly possible. +
++“Is an individual going to be blamed because they couldn’t identify an AI-generated image? Or is a fact-checker going to be the one to take the strain because they’re overwhelmed by this volume?” said Gregory. The responsibility to address AI misinformation “needs to lie on the people who are designing these tools, building these models, and distributing them,” he added. +
++In many cases, Gregory says, it’s unclear exactly what social media platforms’ rules are about allowing AI-generated content. +
++TikTok has one of the more updated policies around “synthetic media,” or media that is created or manipulated by AI. The policy, which was revised in March 2023, allows synthetic media but requires that, if it shows realistic scenes, the image must be clearly disclosed with a caption, sticker, or otherwise. The company also doesn’t allow synthetic media that contains the likeness of any private figure or anyone under 18. TikTok says it worked with outside partners like the industry nonprofit Partnership on AI for feedback on adhering to a framework for responsible AI practices. +
++“While we are excited by the creative opportunities that AI opens up for creators, we are also firmly committed to developing guardrails, such as policies, for its safe and transparent use,” a TikTok spokesperson said in a statement. “Like most of our industry, we continue to work with experts, monitor the progression of this technology, and evolve our approach.” +
++But many other platforms have policies that might need some updating. Meta, which owns Facebook and Instagram, and YouTube both have general rules against manipulated media that misleads users, but those could be clarified regarding what uses are acceptable or not, according to Gregory. Meta’s fact-checking policies state that manipulated media containing misinformation is eligible for fact-checking by its third-party partners, as it did with the fake Pentagon AI explosion claims. +
++“AI is bigger than any single person, company, or country, and requires cooperation between all relevant stakeholders,” Meta said in a statement. “We are actively monitoring new trends and working to be purposeful and evidence-based in our approach to AI-generated content.” +
++Technological solutions to help people fact-check content themselves, like AI detection systems and watermarks, couldn’t come sooner. +
++But NYU’s Tucker says we need to test these solutions to see whether they’re effective in changing people’s minds when they encounter misleading AI content, and what the disclosures need to look to be impactful. For example, if the disclosures that an image or video is AI-generated are too subtle, people could miss it entirely. And sometimes, labels don’t work as expected. For example, Tucker co-authored a study last year showing that high- or low-quality news credibility labels had limited effects on people’s news consumption habits and failed to change people’s perceptions. +
++Still, there’s hope that if AI disclosures are seen not as politicized fact-checks but as neutral context about the origins of an image, they could be more effective. To know whether these labels are resonating with people and changing their minds will require more research. +
++There is an urgency to figure out these problems as AI-generated content floods the internet. In the past, tech companies had time to debate the hypothetical risks of AI misinformation because mainstream generative AI products weren’t yet out in the wild. But those threats are now very real. +
++These new tools that label AI-generated content, while far from perfect, could help mitigate some of that risk. Let’s hope tech companies move forward with the necessary speed to fix problems that come with AI as quickly as they’re being created. +
+The Supreme Court sided with pigs. Will California? +
++Last month, in a welcome surprise to animal welfare advocates, the US Supreme Court sided with pigs over the pork industry. +
++In a 5-4 decision, the Court upheld Proposition 12, a California law that partially bans the sale of pork from farms that keep pregnant breeding pigs, known as sows, in tiny enclosures called gestation crates. They’re akin to forcing a human to live their entire life in a bathtub. (Other parts of the law, which require eggs and veal to come from cage-free animals, took effect last year and were not a part of the Supreme Court case.) +
++While it was a victory for those who argue against caging intelligent, social animals like pigs for months on end, animal welfare wasn’t the main point for the justices. Rather, the case hinged on the ability of US states to set their own standards for how goods imported from other states are produced. California imports nearly all of its pork from other states, and the National Pork Producers Council, an industry trade group that brought the lawsuit, argued that the state’s heightened standards were imposing an unfair burden on other states, particularly top pork producers like Iowa and Minnesota. The industry estimated it would have to spend $294 million to $348 million to convert enough barns to crate-free. +
+ ++Given the conservative, business-friendly majority on the Court, and the fact that 26 mostly red states and the Biden administration sided with the pork producers, the mother pigs’ odds didn’t look good. Animal welfare advocates I spoke to before the ruling assumed it likely wouldn’t go their way, which could have posed an existential threat to animal welfare laws in other states. (Disclosure: The effort to pass Proposition 12 was led by the Humane Society of the United States, where I worked from 2012 to 2017. I worked briefly on Prop 12 in 2018 while at a different animal welfare organization.) +
++To the surprise of both sides, that didn’t happen. But now that Prop 12 has been upheld, there’s another question: How will America’s strongest farm animal welfare law actually be enforced? +
++The animal welfare movement has poured millions of dollars into banning cages and crates for farmed animals, a strategy that has proven surprisingly successful. Hundreds of food corporations have pledged to source exclusively cage-free eggs and/or pork, and over a dozen states have passed what are called “production” bans, which prohibit in-state meat or egg producers from using cages and crates for one or more farmed animal species. Most of these states aren’t themselves agricultural heavyweights — they import most of their animal products from other states. So as a way of affecting production elsewhere, eight states have passed “sales” bans, like California’s Prop 12, which go much further by banning the sale of eggs, pork, and/or veal from caged animals raised anywhere in the world. +
+ ++All told, California’s Prop 12 should get around 40 million egg-laying hens, tens of thousands of veal calves, and half a million sows out of cages and crates each year. Pigs will go from having around 14 square feet of space to 24 square feet, while hens will go from around 75 square inches to double the space or more. Such laws don’t create humane conditions, as the animals are still in factory farms, but it’s progress nonetheless. +
++However, Prop 12 does have important carveouts for industry. +
++For example, mother pigs can still be confined in crates for five days prior to the expected date of birth, and for several weeks after while they nurse piglets. Importantly, pork that goes into processed or precooked foods, like hot dogs, soups, and frozen pizzas — which accounts for 42 percent of California’s pork consumption — is also exempt. (The law only covers whole, uncooked pork cuts like bacon or ribs.) +
++But for the law to cover the tens of millions of animals it’s supposed to protect each year, it’ll need to be strongly enforced, which is far from a given with animal protection regulations. +
++“These laws are only as good as the enforcement,” said Bryan Pease, a longtime animal lawyer in California. “Unfortunately, the animal rights movement has a bit of a track record of passing great laws, claiming victory, and then just moving on to the next thing without actually ensuring enforcement.” Pease pointed to California animal welfare laws that had been violated and/or weakly enforced, like laws to prohibit the sale of foie gras, fur, and dogs from puppy mills (as well as cats and rabbits). Pease has sued two San Diego restaurants for allegedly selling foie gras and a store in Orange County for allegedly selling fur, and accused a store in Escondido of selling dogs from puppy mills. +
++As of 2019, there was only evidence of enforcement for one of 16 state cage production bans, according to the Washington, DC-based nonprofit Animal Welfare Institute (AWI). That one instance happened to be in Southern California, where an egg farm was charged in 2017 for not providing hens adequate space. +
++But there’s more evidence that cage-free sales bans have been enforced. Between 2015 and 2019, according to records obtained by AWI, California audited 15 noncompliant egg farms, five of which were out of state. Oregon investigated complaints of a noncompliant egg producer and a noncompliant egg wholesaler, both from out of state. Earlier this year, when Arizona’s cage-free egg law took effect, the state issued hold orders on eggs from out-of-state producers 32 times from entering the food supply until they could verify production methods. +
+ ++Scant evidence of enforcement doesn’t mean there’s mass fraud. It just means enforcing animal welfare laws doesn’t appear to be a priority for states — and the production ban laws don’t even contain provisions that give states authority to enforce them, said Dena Jones of AWI. +
++Absent strict enforcement, compliance shouldn’t be assumed: Meat producers have been repeatedly accused of price fixing, water pollution, labor violations, and cruelty to animals. +
++Jon Lovvorn, chief counsel for animal protection litigation at the Humane Society of the United States, said that “the interlocking nature of the contractual relationships in this industry” — contracts between meat and egg producers and restaurant food distributors and grocers — “make compliance [with Prop 12] more likely.” +
++Prop 12 stipulates that grocers and restaurants aren’t liable for selling noncompliant products so long as they had received written certification of compliance from producers. As a result, meat and egg producers are incentivized to follow the law lest they risk not just the chance of monetary penalties and jail time, but also getting sued by the retailers for selling them noncompliant goods. +
++Lovvorn said that while he expects enforcement to be straightforward, it “doesn’t mean there won’t be problems, and it doesn’t mean there won’t be people cheating the system. … I think that’s going to exist in any enforcement system, but I don’t think this is going to be a huge problem.” +
++The industries that have allegedly flouted some of California’s animal welfare laws, like those that prohibit the sale of foie gras, fur, and dogs, are fragmented and informal. The egg and pork industries, by contrast, are highly consolidated, which could lead to higher rates of compliance compared to other animal industries, Pease believes. +
++“As long as you gain compliance from [the major producers], then you’re pretty much looking at full compliance, and that’s good,” he said. Many of the nation’s largest pork producers had publicly stated that they’ll comply with Prop 12 before the Supreme Court’s decision, including Tyson Foods, Smithfield Foods, Seaboard Foods, Hormel, and Clemens Food Group. +
++There’s ample evidence the egg and pork industries are complying with cage-free laws and keeping more of their animals in cage-free barns. In 2015, when the nation’s first cage-free sales law went into effect, just 6 percent of US hens were cage-free; today it’s close to 40 percent. That number will shoot up in 2024 and 2025 as more state laws come into effect and food corporations fulfill their cage-free commitments. A few years ago, the pork industry said over a quarter of its sows were crate-free for around 70 percent of their four-month pregnancies, up from 10 percent in 2011. +
++Despite the minimal evidence of California enforcing its cage-free laws, Jones of AWI said the state is gearing up to ensure compliance with Prop 12: “California appears to have done the most in terms of setting up enforcement programs, so we’ll have to watch down the road.” +
++The California Department of Food and Agriculture (CDFA) will require pork, veal, and egg producers to work with one of its five accredited third-party certifiers, or with the state itself, to conduct annual audits on their farms. But the enforcement rollout has been, and will continue to be for the months ahead, a bit messy. +
++First, let’s look at the sale of eggs and veal. These components of the law went into effect at the start of 2022, but the CDFA didn’t finalize regulations until September 2022. Since the egg and veal components took effect, producers have been allowed to “self-certify” — essentially attesting to grocers and food distributors that they are in compliance, with the understanding that they are subject to inspection. Egg, veal, and pork producers will all be allowed to self-certify until January 1, 2024, when they’ll need to be certified by a third-party auditor or the CDFA. +
++The pork component of Prop 12, which was delayed due to the Supreme Court case, is now slated to fully take effect on July 1, 2023. The six-month gap that allows producers to self-certify could mean some of the pork sold in California is noncompliant. +
++“During the transition period, it may be difficult to determine if whole pork is from breeding sows raised in compliance with Prop 12,” said CDFA spokesperson Jay Van Rein. +
++Despite the uncertainty, pork producers are pushing to convert their facilities and begin the auditing process. “Since the Supreme Court made their ruling, it’s gotten very busy here,” said Matt Jones, vice president of operations at the accredited certifier Validus, speaking about the flurry of interest from producers looking to understand certification. +
++Grocery stores and other food distributors must also certify that eggs, veal, and pork they sell is compliant, which entails demonstrating through an audit trail that the product came from a certified producer. +
++While the political fight over cages has failed in the courts, members of Congress from states that lead in pork production are looking to overturn Prop 12 on Capitol Hill. Rep. Ashley Hinson (R-IA) is expected to soon reintroduce a bill that would prevent state and local governments from setting standards for how agricultural products imported from other states are produced, which she said would “circumvent what Prop 12 does.” The bill is a repeat of past efforts by former Iowa Rep. Steve King to do the same. +
++On the other end of the political spectrum, progressive Rep. Veronica Escobar (D-TX) last year introduced the PIGS Act to ban gestation crates nationwide. +
++However, animal advocates are more likely to find success at the state level, where the vast majority of legal progress for farmed animals has been made. There are legislative efforts underway to ban gestation crates in Oklahoma, home to around 8 percent of US sows, and allocate funds to help pork producers transition to crate-free systems. +
++The Prop 12 decision could also spur food corporations to eliminate gestation crates from their supply chains, as it’ll expand the crate-free pork supply. In the early 2010s, nearly 60 fast food chains and grocers, including McDonald’s and Kroger, pledged to source crate-free pork, but most still haven’t fulfilled their commitments. +
++For decades, there’s been a race to the bottom on animal welfare on America’s farms, where over 200 million animals are stuffed into cages and crates. It’s torture, but it’s perfectly legal torture in most states, and at least for now, it’s still the dominant method of production for pork and eggs. +
++It should be expected that even incremental laws like Prop 12 will be challenged in the courts by industry, as they’re fundamental to our system of cheap meat. When a law survives, as Proposition 12 has, it shouldn’t come as a surprise if some producers violate it, or if enforcement is spotty. These aren’t reasons to ditch politics as a means of social change for the billions of animals factory-farmed in the US annually, but they should put renewed focus on not just passing laws and improving corporate food policies, but also ensuring they work as intended. +
+What happens if everybody walks off the job? +
++The Hollywood writers strike marked its one-month anniversary on Friday, with no signs of slowing down. While other guilds in the industry are still on the job — except when they’re blocked by picket lines — the writers may soon get company on those picket lines. +
++Two other major entertainment guilds, the Directors Guild of America (DGA) and Screen Actors Guild (SAG-AFTRA), also entered the summer with looming contract expiration dates. Both groups’ agreements with AMPTP, the trade association that represents the industry’s film and TV production companies, end on June 30. A lot could happen between now and then, but the situation is looking dicey. +
++All of that means that come July 1, the studios may be facing a double or even triple strike, in effect shutting Hollywood down completely. +
++The DGA rarely strikes — the last time was in 1987 — and its leadership has not called for a strike authorization vote. But its relations with the AMPTP have been trickier than usual. Negotiations began on May 10, with demands that in part mirror the WGA’s concerns. The main sticking point is wage and residual increases that keep in step with rising costs of living. In particular, lower residuals for shows on streaming services, where the lion’s share of entertainment now lives, have wreaked havoc for many people in the industry, drastically reducing compensation and making it increasingly difficult to just pay the bills. +
+ ++In the past, the DGA has sometimes managed to make an agreement with AMPTP ahead of the start of bargaining, effectively setting a pattern for the WGA and SAG-AFTRA to follow in their own demands. Last November, the DGA sent a “pre-negotiation” offer to the AMPTP, seeking resolution ahead of bargaining. The AMPTP reportedly rejected the DGA’s proposal, meaning both parties came to the bargaining table without an arrangement. +
++The situation seemed to intensify due to an unforced error. On May 23, Warner Bros. Discovery launched Max, its newly rebranded streaming platform, which had previously been named HBO Max. Eagle-eyed observers noticed that in listed credits, the platform lumped writers, directors, producers, and so on into one category labeled “creators.” Aside from the queasy implications that the greatest works of cinema and television were just “content,” the choice on the company’s part ran afoul of hard-fought contract regulations regarding credits for artists. +
++It was a weird choice, and one that set blood boiling in Hollywood. The presidents of the WGA and the DGA issued a rare joint statement, with DGA president Lesli Linka Glatter noting that “The devaluation of the individual contributions of artists is a disturbing trend and the DGA will not stand for it. We intend on taking the strongest possible actions, in solidarity with the WGA, to ensure every artist receives the individual credit they deserve.” +
++By the end of the day, Warner Bros. Discovery announced that it would modify how credits were listed on the platform in compliance with its preexisting contract agreement with the unions. Yet the strong language indicated that the DGA was ready to play hardball. +
++Meanwhile, members of SAG-AFTRA have been vocally supportive of the WGA. This is no shock, since on top of the same issue of residuals and wages, the union — which includes, in addition to film and TV actors, people who work in radio, singers, voice actors, influencers, models, and other media professionals — is concerned about the existential threat posed by AI and other technologies. Even before the WGA’s strike began, SAG-AFTRA issued statements regarding how the use of AI could eliminate or greatly reduce work for its members. +
++Members of SAG-AFTRA have shown up on picket lines to support the writers, and the star power posed by some of its most prominent members helps bring attention to the WGA’s strike. It’s also an effort to remind the studios that when their own negotiations begin, they’re ready for a fight. Underlining that implicit statement, the leadership of SAG-AFTRA unanimously agreed to ask its membership for a strike authorization vote, which concludes this coming Monday, June 5. That’s a move designed to signal solidarity to the AMPTP ahead of negotiations. +
+ ++It’s clear that all of Hollywood’s unions — not just the three with expiring contracts — are working together to show solidarity. Both IATSE, which represents Hollywood’s “below-the-line” workers (everyone from grips to craft services to first aid to electricians), and the Teamsters (who drive trucks, wrangle animals, manage locations, and a lot more) are authorized by their leadership to refuse to cross picket lines, and have made that choice throughout the writers strike. DGA and SAG members have frequently refused as well. +
++The DGA’s negotiations are set to end on June 7, the same day SAG-AFTRA’s negotiations begin. Knowing this, on May 31, the leaders of the Teamsters, IATSE, WGA, and SAG-AFTRA issued a joint statement supporting the DGA in their negotiations, declaring that “as eyes around the world again turn towards the negotiation table, we send a clear message to the AMPTP: Our solidarity is not to be underestimated.” +
++When writers go on strike, some of the industry can still operate, provided their workers are willing to cross picket lines. (Due to available personnel, the WGA also can’t picket every production, and thus chooses strategically.) But if the DGA or SAG-AFTRA walks off the job — or both — then productions will shut down across the board. Hollywood would grind to a halt. +
++Here’s what’s most significant about all of this: All three unions have never gone on strike at the same time, in the history of Hollywood. The fact that this scenario is possible, even likely, emphasizes how extraordinary this moment is in the entertainment business. Technology has always been a major driver in labor negotiations. But the major companies’ use of streaming services, and their demonstrated interest in cutting out humans through the use of tech, poses an existential threat to everyone who makes the TV, movies, and other scripted entertainment that brings in billions of dollars every year. The question, at this juncture, is whether there’s a future for Hollywood at all — or whether entertainment will be swallowed whole by the tech industry. For Hollywood’s artists and craftspeople, that’s a fate worth fighting against. +
++
++
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Room no. 13 -
++One night a guy goes to get a room in a hotel. “Hello, I want a single room for the night please.” “Fine, sir, here’s one of our best rooms. Room 13,” says the concierge and hands him the key. +
++The guy goes upstairs, takes a shower and gets straight into bed. At about 2 0’clock in the morning, two gorgeous naked women come in and slide under the covers. When he realizes what is going on, he starts screwing both of them. He can’t believe what’s happening. Next morning, still surprised by last night’s events, he goes downstairs to settle the bill. “How was your room sir?” asks the receptionist. “Excellent, I will come back again. What do I owe you?” asks the man. +
++“Well. actually, sir, we are doing a promotional offer. Not only do you not have to pay but we give you $10 as a welcome gesture,” says the receptionist. “What?” says the guy, very surprised indeed. “That’s amazing.” He takes the ten-dollar bill and wanders off, debating whether his buddies will believe him or not. Needless to say, after a few days he’s told all his friends and neighbors about room 13 and the amazing night of passion. The next week one of his buddies goes to check out the room. “Room 13 please.” “Certainly, sir, here’s your key.” After he gets in bed, at the same time, 2 o’clock, two girls this time, extremely horny, get in bed and screw his brains out. The next morning, not only does he not have to pay, but he too gets $10. After a month, everyone knows this hotel and especially room 13. Everyone that stays in room 13 gets the same treatment: a good screw and a ten bucks. +
++After a few weeks, the story reaches the President. The President decides to check the story out for himself. He visits the hotel and asks for room 13. He gets the keys and goes upstairs. After a couple of drinks he gets in bed waiting patiently for the naked girls to appear. Indeed at about 2 0’clock in the morning two naked ladies come to bed. They are as horny and wild as all the stories the President has heard. The President gets his pecker out and screws the both of them all night long. This is the night of his life. Next morning he goes to reception and when he asks how much the bill is, the receptionist says, “Nothing to pay, sir. Actually, we are doing an introductory offer. Here’s $50 as a welcome gesture.” Curious, the President asks the receptionist, “Well, that’s strange. Everyone else who comes here gets $10. Why do I get $50?” “Well, sir,” says the receptionist. “This is the first time we’ve filmed a porn movie with a President in it!” +
+ submitted by /u/castle_03
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A Termite walks into a bar -
++And says is the bar tender here +
+ submitted by /u/Golden211
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When my girlfriend got pregnant everything changed -
++My address, my phone number.. +
+ submitted by /u/TreeBearOne
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A woman said to her husband: “I just dreamt that you gave me a necklace of pearls. What do you think it means?” -
++The man smiled and said: “You’ll know tonight.” That evening, the man came home with a small package which he gave to his wife. She embraced him, and then slowly and unwrapped the package. It contained a book entitled, The Meaning of Dreams. +
+ submitted by /u/mr_m_r
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A senior citizen drove his brand new Corvette convertible out of the dealership. -
++Taking off down the road, he floored it to 80 mph, enjoying the wind blowing through what little gray hair he had left. Amazing, he thought as he flew down I-94, pushing the pedal even more. +
++Looking in his rear view mirror, he saw a state trooper behind him, lights flashing and siren blaring. He floored it to 100 mph, then 110, then 120. Suddenly he thought, What am I doing? I’m too old for this, and pulled over to await the trooper’s arrival. Pulling in behind him, the trooper walked up to the Corvette, looked at his watch, and said, “Sir, my shift ends in 30 minutes. Today is Friday. If you can give me a reason for speeding that I’ve never heard before, I’ll let you go.” +
++The old gentleman paused. Then he said, “Years ago, my wife ran off with a state trooper. I thought you were bringing her back.” +
++“Have a good day, sir,” replied the trooper. +
+ submitted by /u/RagsTheRecounter
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