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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>TikTok Tourette’s: are we witnessing a rise in neurological conditions driven by adolescent social media use?</strong> -
<div>
Perceptions of Tourette Syndrome (TS) and tic disorders are often driven by social media. During the COVID-19 pandemic, social media consumption greatly increased, particularly in the adolescent population. In parallel with increased social media consumption, there has also been an increase in tic severity and functional tic-like behavior (FTLB). Given that many of the tic videos posted on social media are misleading, perpetuate false beliefs about TS, or reinforce tic-like behaviors, there is increasing concern that these videos are driving the rapid increase in FTLBs. Several studies have reviewed newly presenting cases of FTLB and have found shared characteristics, including that a higher proportion of affected individuals are female, there is a low proportion with a history of childhood or family tics, and symptom onset is typically acute and develops in the teenage years. In addition, the quality of the tics seen in association with FTLB mirror many of the tics seen on popular social media channels, with higher rates of coprophenomena, tic attacks, and involvement of the trunk and extremities than is seen with typical tics. FTLBs are likely a specific subgroup of functional tics largely influenced by the portrayal of and growing popularity of functional tics posted on social media during the COVID-19 pandemic. However, several factors, including increased anxiety, social isolation, and social media use in general during the pandemic are likely also contributing factors to the surge of FTLBs seen recently. In this era of increased social media consumption, it will become increasingly important for clinicians to educate patients about where and how medical information is spread, to ensure the best possible diagnosis, treatment, and outcomes for patients.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/vs3tm/" target="_blank">TikTok Tourette’s: are we witnessing a rise in neurological conditions driven by adolescent social media use?</a>
</div></li>
<li><strong>COVID-19-associated AKI in hospitalized US patients: incidence, temporal trends, geographical distribution, risk factors and mortality</strong> -
<div>
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Background: Acute kidney injury (AKI) is associated with mortality in patients hospitalized with COVID-19, however, its incidence, geographic distribution, and temporal trends since the start of the pandemic are understudied. Methods: Electronic health record data were obtained from 53 health systems in the United States (US) in the National COVID Cohort Collaborative (N3C). We selected hospitalized adults diagnosed with COVID-19 between March 6th, 2020, and January 6th, 2022. AKI was determined with serum creatinine (SCr) and diagnosis codes. Time were divided into 16-weeks (P1-6) periods and geographical regions into Northeast, Midwest, South, and West. Multivariable models were used to analyze the risk factors for AKI or mortality. Results: Out of a total cohort of 306,061, 126,478 (41.0 %) patients had AKI. Among these, 17.9% lacked a diagnosis code but had AKI based on the change in SCr. Similar to patients coded for AKI, these patients had higher mortality compared to those without AKI. The incidence of AKI was highest in P1 (49.3%), reduced in P2 (40.6%), and relatively stable thereafter. Compared to the Midwest, the Northeast, South, and West had higher adjusted AKI incidence in P1, subsequently, the South and West regions continued to have the highest relative incidence. In multivariable models, AKI defined by either SCr or diagnostic code, and the severity of AKI was associated with mortality. Conclusions: Uncoded cases of COVID-19-associated AKI are common and associated with mortality. The incidence and distribution of COVID-19-associated AKI have changed since the first wave of the pandemic in the US.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.02.22279398v1" target="_blank">COVID-19-associated AKI in hospitalized US patients: incidence, temporal trends, geographical distribution, risk factors and mortality</a>
</div></li>
<li><strong>Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)</strong> -
<div>
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Background: The imposition of restrictions on social mixing early in the COVID-19 pandemic was followed by a reduction in asthma exacerbations in multiple settings internationally. Temporal trends in social mixing, incident acute respiratory infections (ARI) and asthma exacerbations following relaxation of COVID-19 restrictions have not yet been described. Methods: We conducted a population-based longitudinal study in 2,312 UK adults with asthma between November 2020 and April 2022. Details of face covering use, social mixing, incident ARI and moderate/severe asthma exacerbations were collected via monthly on-line questionnaires. Temporal changes in these parameters were visualised using Poisson generalised additive models. Multilevel logistic regression was used to test for associations between incident ARI and risk of asthma exacerbations, adjusting for potential confounders. Results: Relaxation of COVID-19 restrictions from April 2021 coincided with reduced face covering use (p&lt;0.001), increased frequency of indoor visits to public places and other households (p&lt;0.001) and rising incidence of COVID-19 (p&lt;0.001), non-COVID-19 ARI (p&lt;0.001) and moderate/severe asthma exacerbations (p=0.007). Incident non-COVID-19 ARI associated independently with increased risk of asthma exacerbation (adjusted odds ratio 5.75, 95% CI 4.75 to 6.97) as did incident COVID-19, both prior to emergence of the omicron variant of SARS-CoV-2 (5.89, 3.45 to 10.04) and subsequently (5.69, 3.89 to 8.31). Conclusions: Relaxation of COVID-19 restrictions coincided with decreased face covering use, increased social mixing and a rebound in ARI and asthma exacerbations. Associations between incident ARI and risk of moderate/severe asthma exacerbation were similar for non-COVID-19 ARI and COVID-19, both before and after emergence of the SARS-CoV-2 omicron variant.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.01.22279473v1" target="_blank">Rebound in asthma exacerbations following relaxation of COVID-19 restrictions: a longitudinal population-based study (COVIDENCE UK)</a>
</div></li>
<li><strong>Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA</strong> -
<div>
Background: Because circulating DNA (cirDNA) are mainly detected as mononucleosome-associated circulating DNA (mono-N cirDNA) in blood apoptosis has until now been considered as the main source of cirDNA. The mechanism of cirDNA release into the circulation, however, is still not fully understood. This work addresses that knowledge gap, working from the postulate that neutrophil extracellular traps (NET) may be a source of cirDNA, and by investigating whether NET may directly produce mono-N cirDNA Methods: We used the synergistic analytical information provided by specifically quantifying DNA by qPCR, and analyzing fragment size analysis by shallow WGS, and capillary electrophoresis to unequivocally study the following: the in vitro kinetics of cell derived genomic high molecular weight (gHMW) DNA degradation in serum; the production of extracellular DNA and NET markers such as neutrophil elastase (NE) and myeloperoxidase (MPO) by ex vivo activated neutrophils; in vitro NET degradation in serum. We also performed an in vivo study in knockout mice, and an in vitro study of gHMW DNA degradation, to elucidate the role of NE and MPO in effecting DNA degradation and fragmentation. We then compared the NET associated markers and fragmentation size profiles of cirDNA in plasma obtained from patients with inflammatory diseases found to be associated with NET formation and high levels of cirDNA (COVID-19, N= 28; systemic lupus erythematosus, N= 10; metastatic colorectal cancer, N= 10; and from healthy individuals, N= 114). Results: Our studies reveal that: gHMW DNA degradation in serum results in the accumulation of mono-N DNA (81.3% of the remaining DNA following 24H incubation in serum corresponded to mono-N DNA); ex vivo NET formation, as demonstrated by a concurrent 5-, 5- and 35-fold increase of NE, MPO, and cell-free DNA (cfDNA) concentration in PMA-activated neutrophil culture supernatant, leads to the release of high molecular weight DNA that degrades down to mono-N in serum; NET mainly in the form of gHMW DNA generate mono-N cirDNA (2% and 41% of the remaining DNA after 2 hours in serum corresponded to 1-10 kbp fragments and mono-N, respectively) independent of any cellular process when degraded in serum; NE and MPO may contribute synergistically to NET autocatabolism, resulting in a 25-fold decrease in total DNA concentration and a DNA fragment size profile similar to that observed from cirDNA following 8h incubation with both NE and MPO; the cirDNA size profile of NE KO mice significantly differed from that of the WT, suggesting NE involvement in DNA degradation; and a significant increase in the levels of NE, MPO and cirDNA was detected in plasma samples from lupus, COVID-19 and mCRC, showing a high correlation with these inflammatory diseases, while no correlation of NE and MPO with cirDNA was found in HI. Conclusions: Our work thus describes the mechanisms by which NET and cirDNA are linked, by demonstrating that NET are a major source of mono-N cirDNA independent of apoptosis, and thus establishing a new paradigm of the mechanisms of cirDNA release in normal and pathological conditions, as well as demonstrating a link between immune response and cirDNA.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.01.506266v1" target="_blank">Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA</a>
</div></li>
<li><strong>Novel monoclonal antibodies showing broad neutralizing activity for SARS-CoV-2 variants including Omicrons BA.5 and BA.2.75</strong> -
<div>
We identified novel neutralizing monoclonal antibodies against SARS-CoV-2 variants (including Omicron) from individuals received two doses of mRNA vaccination after they had been infected with wildtype. We named them MO1, MO2 and MO3. MO1 shows high neutralizing activity against authentic variants: D614G, Delta, BA.1, BA.1.1, BA.2, and BA.2.75 and BA.5. Our findings confirm that the wildtype-derived vaccination can induce neutralizing antibodies that recognize the epitopes conserved among the SARS-CoV-2 variants (including BA.5 and BA.2.75). The monoclonal antibodies obtained herein could serve as novel prophylaxis and therapeutics against not only current SARS-CoV-2 viruses but also future variants that may arise.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.02.506305v1" target="_blank">Novel monoclonal antibodies showing broad neutralizing activity for SARS-CoV-2 variants including Omicrons BA.5 and BA.2.75</a>
</div></li>
<li><strong>SARS-CoV-2 nucleocapsid protein inhibits the stress response through RNA-binding domain N2b</strong> -
<div>
The nucleocapsid protein N of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enwraps and condenses the viral genome for packaging but is also an antagonist of the innate antiviral defense. It suppresses the integrated stress response (ISR), purportedly by interacting with stress granule (SG) assembly factors G3BP1 and 2, and inhibits type I interferon responses. To elucidate its mode of action, we systematically deleted and over-expressed distinct regions and domains. We show that N via domain N2b blocks PKR-mediated ISR activation, as measured by suppression of ISR-induced translational arrest and SG formation. N2b mutations that prevent dsRNA binding abrogate these activities also when introduced in the intact N protein. Substitutions reported to block post-translation modifications of N or its interaction with G3BP1/2 did not have a detectable additive effect. In an encephalomyocarditis virus-based infection model, N2b - but not a derivative defective in RNA binding - prevented PKR activation, inhibited {beta}-interferon expression and promoted virus replication. Apparently, SARS-CoV-2 N inhibits innate immunity by sequestering dsRNA to prevent activation of PKR and RIG-I-like receptors. Observations made for the N protein of human coronavirus 229E suggests that this may be a general trait conserved among members of other orthocoronavirus (sub)genera.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.02.506332v1" target="_blank">SARS-CoV-2 nucleocapsid protein inhibits the stress response through RNA-binding domain N2b</a>
</div></li>
<li><strong>White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern</strong> -
<div>
The spillover of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans into white-tailed deer (WTD) and its ability to transmit from deer-to-deer raised concerns about the role of WTD in the epidemiology and ecology of the virus. In the present study, we conducted a comprehensive investigation to assess the prevalence, genetic diversity, and evolution of SARS-CoV-2 in WTD in the State of New York (NY). A total of 5,462 retropharyngeal lymph node (RPLN) samples collected from free-ranging hunter-harvested WTD during the hunting seasons of 2020 (Season 1, September-December 2020, n=2,700) and 2021 (Season 2, September-December 2021, n=2,762) were tested by SARS-CoV-2 real-time RT-PCR. SARS-CoV-2 RNA was detected in 17 samples (0.6%) from Season 1 and in 583 (21.1%) samples from Season 2. Hotspots of infection were identified in multiple confined geographic areas of NY. Sequence analysis of SARS-CoV-2 genomes from 164 samples demonstrated the presence multipls SARS-CoV-2 lineages as well as the co-circulation of three major variants of concern (VOCs) (Alpha, Gamma, and Delta) in WTD. Our analysis suggests the occurrence of multiple spillover events (human-to-deer) of the Alpha and Delta lineages with subsequent deer-to-deer transmission of the viruses. Detection of Alpha and Gamma variants in WTD long after their broad circulation in humans in NY suggests that WTD may serve as a wildlife reservoir for VOCs no longer circulating in humans. Thus, implementation of continuous surveillance programs to monitor SARS-CoV-2 dynamics in WTD are warranted, and measures to minimize virus transmission between humans and animals are urgently needed.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.09.02.506368v1" target="_blank">White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern</a>
</div></li>
<li><strong>COVID-19 disruptions of food systems and nutrition services in Ethiopia: Evidence of the impacts and policy responses</strong> -
<div>
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Background: Since its first case of COVID-19 on March 13, 2020 and Ethiopia has exerted efforts to curb the spread of the Coronavirus disease 2019 (COVID-19) without imposing a nationwide lockdown. Globally, COVID-19 related disruptions and mitigation measures have impacted livelihoods and food systems, nutrition, as well as access and use of health services. Objective: To develop a comprehensive understanding of the impacts of the COVID-19 pandemic on food security and maternal and child nutrition and health services and to synthesize lessons from policy responses to the COVID-19 pandemic in Ethiopia. Methods: We conducted a review of literature and 8 key informant interviews across government agencies, donors, and non-governmental organizations (NGOs), to map the impacts of the COVID-19 pandemic on the food and health systems in Ethiopia. We summarized policy responses and identified recommendations for future actions related to the COVID-19 pandemic and other future emergencies. Results: The impacts of the COVID-19 pandemic were felt across the food system. Disruptions were noted in inputs supply due to travel restrictions and closed borders restricting trade, reduced in-person support by agriculture extension workers, income losses, increases in food prices, and the reduction in food security and consumption of less diverse diets. Maternal and child health services were disrupted due to fear of contacting COVID-19, diversion of resources, and lack of personal protective equipment. Disruptions eased over time due to the expansion of social protection, through the Productive Safety Net Program, and the increased outreach and home service provision by the health extension workers. Conclusion: Ethiopia experienced disruptions to food systems and expanded existing social protection and public health infrastructure and leveraged partnerships with non-state actors. Nevertheless, vulnerabilities and gaps remain and there is a need for a long-term strategy that considers the cyclical nature of COVID-19 cases.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.08.31.22279432v1" target="_blank">COVID-19 disruptions of food systems and nutrition services in Ethiopia: Evidence of the impacts and policy responses</a>
</div></li>
<li><strong>Spatial analysis of COVID-19 booster vaccine uptake in Scotland, and projection of future distributions</strong> -
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Vaccine hesitancy is one of the critical challenges for the implementation of a successful vaccination strategy. Rates of vaccine hesitancy and refusal vary substantially across different socioeconomic groups, and can result in those considered most vulnerable to disease having the lowest levels of uptake. Widespread coverage of COVID-19 vaccination is of particular importance as prevalence remains high, in effort to reduce overall burden from serious disease. Scotland9s COVID-19 vaccination programme has progressed to booster vaccinations, however uptake is falling across successive doses, and there is concern that some vulnerable individuals will not have sustained protection. To this end we analyse uptake in Scotland9s first (starting September 2021) booster dose round, as a benchmark for future rounds. We fit a machine learning model to explain variation in uptake across Scotland at fine population scales. The model is able to estimate a neighbourhood9s booster uptake with high precision using its population structure and relative deprivation alone, without any knowledge of geographic location. This is indicative of a strong relationship between increasing local deprivation and falling uptake, and specifically in those failing to return for a booster, despite getting a first dose. Geographically, this manifests as clusters of lower uptake, coinciding with communities with higher deprivation. With an upcoming booster rollout in Autumn 2022, we use first booster uptake as a baseline, to generate a set of plausible distributions for future uptake, if nationwide uptake were to fall. We make the core assumption that as uptake falls, trends with respect to deprivation will persist. Projected uptake declines more rapidly in clusters of more deprived neighbourhoods. If these projected distributions were to manifest, gaps in immunity would emerge in more deprived communities, which have historically had the highest rates of COVID-19 hospitalisation and mortality.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.08.30.22279415v1" target="_blank">Spatial analysis of COVID-19 booster vaccine uptake in Scotland, and projection of future distributions</a>
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<li><strong>The impact and progression of the COVID-19 pandemic in Bulgaria in its first two years</strong> -
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After initially having low levels of SARS-CoV-2 infections for much of the year, at the end of 2020 Bulgaria experienced a major epidemic surge, which caused the highest recorded excess mortality in Europe and among the highest in the word (Excess Mortality Rate, or EMR ~0.25%). Two more major waves followed in 2021, followed by another one in early 2022. In this study we analyze the temporal and spatial patterns of excess mortality at the national and local levels and across different demographic groups in Bulgaria, and compare those at the European level. The country has continued to exhibit the previous pattern of extremely high excess mortality as measured both by crude mortality metrics (EMR ~1.05% up to the end of March 2022) and by standardized ones – Potential Years of Life Lost (PYLL) and Aged-Standardized Years of life lost Rate (ASYR). Unlike Western Europe, the bulk of excess mortality in Bulgaria, as well as in several other countries in Eastern Europe, occurred in the second year of the pandemic, likely related to the differences in the levels of vaccination coverage between these regions. We also observe even more extreme levels of excess mortality at the regional level and in some subpopulations (e.g. total EMR values for males ~2% and EMR values for males aged 40-64 ~1% in certain areas). We discuss these observations in light of the estimates of infection fatality rate (IFR) and eventual population fatality rate (PFR) made early in the course of the pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.01.22279496v1" target="_blank">The impact and progression of the COVID-19 pandemic in Bulgaria in its first two years</a>
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<li><strong>Cardiac Magnetic Resonance Findings of COVID-19 Vaccine Associated Myocarditis at Intermediate Follow Up: a Comparison to Classic Myocarditis and MIS-C Related Myocarditis</strong> -
<div>
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Objective: To report intermediate cardiac magnetic resonance (CMR) findings of COVID-19 vaccine associated myocarditis (C-VAM) and compare to classic myocarditis (CM) and multisystem inflammatory syndrome in children (MIS-C). Study Design: Retrospective cohort study including children diagnosed with C-VAM from 5/2021 through 12/2021 with early and intermediate CMR. Patients with CM and MIS-C with intermediate CMR were included for comparison. Results: There were 8 patients with C-VAM, 20 with CM, and 61 with MIS-C. Among those with C-VAM, CMR performed at median 3 days (IQR 3, 7) revealed 2/8 patients with left ventricular ejection fraction (LVEF)&lt;55%, 7/7 patients with late gadolinium enhancement (LGE), and 5/8 patients with elevated native T1 values. Borderline T2 values suggestive of myocardial edema were present in 6/8. Follow-up CMRs performed at median 107 days (IQR 97, 177) showed normal ventricular systolic function, T1, and T2 values; 3/7 patients had LGE. At intermediate follow up the C-VAM group had a lower percentage of LVEF&lt;55% compared to CM and MIS-C (0.0 vs 30.0 vs 6.6%, respectively, p=0.018) and an intermediate degree of LGE (42.9 vs 75.0 vs 3.3%, respectively, p&lt;0.001). Pairwise comparisons showed fewer myocardial segments with LGE in the C-VAM group versus CM (4/119 vs 42/340, p=0.004) and more segments with LGE than MIS-C (4/119 vs 2/1020, p=0.0014). Conclusion: Patients with C-VAM had no evidence of active inflammation or ventricular dysfunction on intermediate CMR although a minority had persistent LGE. Intermediate findings in C-VAM may be favorable compared to CM though LGE is more common compared to MIS-C.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.09.01.22279517v1" target="_blank">Cardiac Magnetic Resonance Findings of COVID-19 Vaccine Associated Myocarditis at Intermediate Follow Up: a Comparison to Classic Myocarditis and MIS-C Related Myocarditis</a>
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<li><strong>Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C)</strong> -
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Multisystem Inflammatory Syndrome in Children (MIS-C) is a systemic inflammatory condition that follows SARS-CoV2 infection or exposure in children. Clinical presentations are highly variable and include fever, gastrointestinal (GI) disease, shock, and Kawasaki Disease-like illness (MIS-C/KD). Compared to patients with acute COVID, patients with MIS-C have a distinct immune signature and expansion of TRVB11 expressing T cells. However, the relationship between immunological and clinical phenotypes of MIS-C is unknown. Here, we measured serum biomarkers, TCR repertoire, and SARS-CoV2-specific T cell responses in a cohort of 76 MIS-C patients. Serum biomarkers associated with macrophage and Th1 activation were elevated in patients with shock, consistent with previous reports. Significantly increased SARS-CoV-2-induced IFN-g; IL-2, and TNF-a; production were seen in CD4+ T cells from patients with neurologic involvement and respiratory failure. Diarrhea was associated with a significant reduction in shock-associated serum biomarkers, suggesting a protective effect. TRVB11 usage was highly associated with MIS-C/KD and coronary aneurysms, suggesting a potential biomarker for these manifestations in MIS-C patients. By identifying novel immunologic associations with the different clinical phenotypes of MIS-C, this study provides insights into the clinical heterogeneity of MIS-C. These unique immunophenotypic associations could provide biomarkers to identify patients at risk for severe complications of MIS-C, including shock and MIS-C/KD.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.08.31.22279265v1" target="_blank">Deep immune profiling uncovers novel associations with clinical phenotypes of Multisystem Inflammatory Syndrome in Children (MIS-C)</a>
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<li><strong>Vaccine Effectiveness Against Hospitalization Among Adolescent and Pediatric SARS-CoV-2 Cases in Ontario, Canada</strong> -
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Background: Vaccines against SARS-CoV-2 have been shown to reduce risk of infection, as well as severe disease among those with breakthrough infection, in adults. The latter effect is particularly important as Immune evasion by Omicron variants appears to have made vaccines less effective for prevention of infection. There is currently little available information on the protection conferred by vaccination against severe illness due to SARS-CoV-2 in children. Methods: To minimize confounding by changing vaccination practices and dominant circulating viral variants, we performed an age- and time-matched nested case-control design. Reported SARS-CoV-2 case records in Ontario children and adolescents aged 4 to 17 were linked to vaccination records. We used multivariable logistic regression to estimate the effectiveness of one and two vaccine doses against hospitalization. Results: We identified 130 hospitalized SARS-CoV-2 cases and 1,300 non-hospitalized, age- and time-matched controls, with disease onset between May 28, 2021 and January 9, 2022. One vaccine dose was shown to be 34% effective against hospitalization among SARS-CoV-2 cases (aOR = 0.66 [95% CI: 0.34, 1.21]). In contrast, two doses were 56% (aOR = 0.44 [95% CI: 0.23, 0.83]) effective at preventing hospitalization among SARS-CoV-2 cases. Exploratory instrumental variable analyses, and calculation of E-values, suggested that these effects are unlikely to be explained by unmeasured confounding. Conclusions: Even with immune evasion by SARS-CoV-2 variants, two vaccine doses continue to provide protection against hospitalization among adolescent and pediatric SARS-CoV-2 cases, even when the vaccines do not prevent infection.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.24.22272919v2" target="_blank">Vaccine Effectiveness Against Hospitalization Among Adolescent and Pediatric SARS-CoV-2 Cases in Ontario, Canada</a>
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<li><strong>Evaluation of Secondary Chemistry due to Disinfection of Indoor Air with Germicidal Ultraviolet Lamps</strong> -
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The disinfection of air using Germicidal Ultraviolet light (GUV) is a long-standing technique, which has received intense attention during the COVID-19 pandemic. GUV generally uses UVC lamps as its light source, which are known to initiate photochemistry in air. However, the impact of GUV on indoor air quality and chemistry has not been investigated in detail, to our knowledge. In this study, we model the chemistry initiated by GUV at 254 or 222 nm (“GUV254” or “GUV222”) in a typical room with typical indoor pollutant levels, and for different ventilation levels. GUV254 is irritating for skin and eyes, has an occupational exposure limit, and thus these fixtures typically irradiate a smaller volume near the ceiling, or inside ventilation ducts. In contrast, GUV222 is described by some as harmless to skin or eyes due to rapid absorption in a very thin external layer. Our analysis showed that GUV254 is able to significantly photolyze O3, generating OH radicals, which initiates the oxidation of all indoor volatile organic compounds (VOCs). While secondary organic aerosol (SOA) can be formed as a product of VOC oxidation, most of SOA in our case studies is produced through GUV-independent terpene ozonolysis. GUV254-induced SOA formation is of the order of 0.1-1 μg m-3. GUV222 with the same effective virus removal rate makes a smaller impact on indoor air quality at mid to high ventilation rates, mainly because of the significantly lower UV irradiance needed and substantially less efficient O3 photolysis (for primary OH generation) than at 254 nm, while it has a higher impact than GUV254 when ventilation is poor due to a small but significant photochemical production of O3 at 222 nm.
</p>
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.08.25.22279238v2" target="_blank">Evaluation of Secondary Chemistry due to Disinfection of Indoor Air with Germicidal Ultraviolet Lamps</a>
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<li><strong>Rush hour-and-a-half: traffic is spreading out post-lockdown</strong> -
<div>
Urban roadways are used inefficiently, with capacity scaled to meet peak demands and underutilization at off-peak hours. The COVID-19 pandemic has significantly disrupted the transportation system, and one possible outcome is a spreading of rush hour. We use six years of highway sensor data from the California state highway system to evaluate that possibility, and find that peaks are spreading in the post-lockdown period, the spreading is statistically significant, and has been relatively stable since summer 2021. Spreading of peak travel periods calls into question highway expansion plans based on pre-pandemic travel forecasts.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/6khsj/" target="_blank">Rush hour-and-a-half: traffic is spreading out post-lockdown</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Booster Study of COVID-19 Protein Subunit Recombinant Vaccine</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: SARS-CoV-2 subunit protein recombinant vaccine;   Biological: Active Comparator<br/><b>Sponsors</b>:   PT Bio Farma;   Faculty of Medicine Universitas Padjadjaran;   Faculty of Medicine Universitas Udayana<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Immunogenicity and Safety of a Recombinant Protein COVID-19 Vaccine SCTV01E-1 in Population Aged Above 18 Years</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: SCTV01E-1 on D0;   Biological: SCTV01E-1 on D28;   Biological: SCTV01E-1 on D150;   Biological: SCTV01E on D0;   Biological: SCTV01E on D28;   Biological: SCTV01E on D150;   Biological: SCTV01E-1 on D120;   Biological: SCTV01E on D120<br/><b>Sponsor</b>:   Sinocelltech Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Novel Parameter LIT/N That Predicts Survival in COVID-19 ICU Patients</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Diagnostic Test: the LIT test<br/><b>Sponsors</b>:   Gazi University;   Oxford MediStress<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of ES16001 in Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: ES16001 40 mg;   Drug: ES16001 80 mg;   Drug: ES16001 160 mg;   Drug: Placebo<br/><b>Sponsor</b>:   Genencell Co. Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase 2a Trial to Evaluate Safety and Immunogenicity of COVID-19 Vaccine Strategies in HIV-infected/Uninfected Adults.</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ad26.COV2.S (VAC31518, JNJ-78436735) Vaccine, SARS-CoV-2 rS (CovovaxTM), BNT162b2 (Pfizer)<br/><b>Sponsors</b>:   The Aurum Institute NPC;   Coalition for Epidemic Preparedness Innovations<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID Protection After Transplant - Sanofi GSK (CPAT-SG) Study</strong> - <b>Conditions</b>:   COVID-19;   Kidney Transplant<br/><b>Intervention</b>:   Biological: Sanofi-GSK monovalent (B.1.351) CoV2 preS dTM-AS03 COVID-19 vaccine<br/><b>Sponsors</b>:   National Institute of Allergy and Infectious Diseases (NIAID);   PPD;   Johns Hopkins University;   Sanofi Pasteur, a Sanofi Company<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of COVID-19 Vaccine, AdCLD-CoV19-1</strong> - <b>Conditions</b>:   COVID-19;   Vaccines<br/><b>Intervention</b>:   Biological: AdCLD-CoV19-1<br/><b>Sponsors</b>:   International Vaccine Institute;   Cellid Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Smartphone Intervention for Overdose and COVID-19</strong> - <b>Conditions</b>:   Substance Use Disorders;   Overdose;   COVID-19<br/><b>Intervention</b>:   Device: iThrive WI Intervention<br/><b>Sponsors</b>:   University of Wisconsin, Madison;   National Institute on Drug Abuse (NIDA)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Safety and Immunogenicity of COVID-19 and Influenza Combination Vaccine</strong> - <b>Conditions</b>:   COVID-19;   Influenza<br/><b>Interventions</b>:   Drug: CIC Vaccine;   Drug: qNIV Vaccine;   Drug: SARS-CoV-2 rS Vaccine;   Drug: Influenza Vaccine<br/><b>Sponsor</b>:   Novavax<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Assess Efficacy and Safety of Treamid for Patients With Reduced Exercise Tolerance After COVID-19</strong> - <b>Conditions</b>:   SARS-CoV-2 Infection;   Lung Fibrosis<br/><b>Interventions</b>:   Drug: Treamid;   Drug: Treamid twice a day;   Drug: Treamid once a day;   Drug: Placebo<br/><b>Sponsor</b>:   PHARMENTERPRISES LLC<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Self-proning and Repositioning in COVID-19 Outpatients at Risk of Complicated Illness</strong> - <b>Conditions</b>:   COVID-19;   COVID-19 Pneumonia;   Proning;   Hospitalization;   Death;   Outpatient;   Complication<br/><b>Intervention</b>:   Other: Self-proning<br/><b>Sponsors</b>:   Unity Health Toronto;   Applied Health Research Centre<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Immulina TM Supplements With PASC Patients</strong> - <b>Condition</b>:   Post Acute COVID-19 Syndrome<br/><b>Interventions</b>:   Dietary Supplement: Immulina TM;   Dietary Supplement: Placebo<br/><b>Sponsors</b>:   University of Mississippi Medical Center;   National Institute of General Medical Sciences (NIGMS)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of Clinical Performance and Usability of iStatis COVID-19 Ag Rapid Test at POC</strong> - <b>Conditions</b>:   COVID-19 Virus Infection;   COVID-19;   Coronavirus Disease-19;   COVID-19 Pandemic;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Diagnostic Test: iStatis COVID-19 Ag Rapid Test;   Diagnostic Test: “COVID-19 RT-PCR Test EUA Number: EUA200011, Company: Laboratory Corporation of America (”Labcorp")<br/><b>Sponsor</b>:   bioLytical Laboratories<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Resilience Intervention for Health Professionals COVID-19</strong> - <b>Condition</b>:   Mental Health Wellness 1<br/><b>Intervention</b>:   Other: Mindfulness-based Intervention<br/><b>Sponsor</b>:   Universidad de Monterrey<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Addressing Post-COVID-19 Musculoskeletal Symptoms</strong> - <b>Conditions</b>:   Telemedicine;   Musculoskeletal Disease;   SARS-CoV-2;   Pain;   COVID-19;   Exercise<br/><b>Interventions</b>:   Other: Multicomponent exercise program;   Other: Tele-health primary care rehabilitation program<br/><b>Sponsor</b>:   Universidad Europea de Madrid<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dipeptidylpeptidase (DPP)-4 inhibitor therapy increases circulating levels of anti-inflammatory soluble frizzle receptor protein (sFRP)-5 which is decreased in severe COVID-19 disease</strong> - Obesity and type 2 diabetes (T2D) show an increased risk for a severe COVID-19 disease. Treatment with DPP4 inhibitor (DPP4i) results in reduced mortality and better clinical outcome. Here, we aimed to identify potential mechanisms for the observed DPP4i effect in COVID-19. Comparing T2D subjects with and without DPP4i treatment, we identified a significant increase of the anti-inflammatory adipokine sFRP5 in relation to DPP4 inhibition. sFRP5 is a specific antagonist to Wnt5a, a glycopeptide…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Retro-2 alters Golgi structure</strong> - Retro-2 directly interacts with an ER exit site protein, Sec16A, inhibiting ER exit of a Golgi tSNARE, Syntaxin5, which results in rapid re-distribution of Syntaxin5 to the ER. Recently, it was shown that SARS-CoV-2 infection disrupts the Golgi apparatus within 6-12 h, while its replication was effectively inhibited by Retro-2 in cultured human lung cells. Yet, exactly how Retro-2 may influence ultrastructure of the Golgi apparatus have not been thoroughly investigated. In this study, we…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Pathogenesis of African Trypanosomiasis</strong> - African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts. Therefore, trypanosomes have developed strategies to continuously escape innate and adaptive responses of the immune system, while also preventing premature death of the host. The pathology linked to infection mainly results from inflammation and includes anemia and brain dysfunction in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion</strong> - Hundreds of millions of SARS-CoV-2 mRNA-LNP vaccine doses have already been administered to humans. However, we lack a comprehensive understanding of the immune effects of this platform. The mRNA-LNP-based SARS-CoV-2 vaccine is highly inflammatory, and its synthetic ionizable lipid component responsible for the induction of inflammation has a long in vivo half-life. Since chronic inflammation can lead to immune exhaustion and non-responsiveness, we sought to determine the effects of pre-exposure…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cotton flower metabolites inhibit SARS-CoV-2 main protease</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading globally for over two years, causing serious contagious disease and incalculable damage. The introduction of vaccines has slowed the spread of SARS-CoV-2 to some extent, but there remains a need for specific and effective treatment. The high chemical diversity and safety profiles of natural products make them a potential source of effective anti-SARS-CoV-2 drugs. Cotton plant is one of the most important economic and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection</strong> - Acinetobacter baumannii is an opportunistic pathogen and an emerging global health threat. Within healthcare settings, major presentations of A. baumannii include bloodstream infections and ventilator-associated pneumonia. The increased prevalence of ventilated patients during the COVID-19 pandemic has led to a rise in secondary bacterial pneumonia caused by multidrug resistant (MDR) A. baumannii. Additionally, due to its MDR status and the lack of antimicrobial drugs in the development…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Middle East respiratory syndrome coronavirus ORF4b protein inhibits TLR7- and TLR9-dependent alpha interferon induction</strong> - The Toll-like receptor (TLR)7- and TLR9-dependent signaling cascade is responsible for production of a large amount of alpha interferon by plasmacytoid dendritic cells upon viral infection. Here, we show that Middle East respiratory syndrome coronavirus (MERS-CoV) accessory protein ORF4b has the most potential among the MERS-CoV accessory proteins to inhibit the TLR7/9-signaling-dependent alpha interferon production. ORF4b protein, which has a bipartite nuclear localization signal, was found to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Human ACE2 Peptide-Attached Plasmonic-Magnetic Heterostructure for Magnetic Separation, Surface Enhanced Raman Spectroscopy Identification, and Inhibition of Different Variants of SARS-CoV-2 Infections</strong> - The emergence of Alpha, Beta, Gamma, Delta, and Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for several million deaths up to now. Because of the huge amount of vaccine escape mutations in the spike (S) protein for different variants, the design of material for combating SARS-CoV-2 is very important for our society. Herein, we report on the design of a human angiotensin converting enzyme 2 (ACE2) peptide-conjugated plasmonic-magnetic…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eugenol alleviates transmissible gastroenteritis virus-induced intestinal epithelial injury by regulating NF-κB signaling pathway</strong> - Increasing evidence supports the ability of eugenol to maintain intestinal barrier integrity and anti-inflammatory in vitro and in vivo; however, whether eugenol alleviates virus-mediated intestinal barrier damage and inflammation remains a mystery. Transmissible gastroenteritis virus (TGEV), a coronavirus, is one of the main causative agents of diarrhea in piglets and significantly impacts the global swine industry. Here, we found that eugenol could alleviate TGEV-induced intestinal functional…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System</strong> - Transsynaptic transport is the most accepted proposal to explain the SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows that neurons do not express the SARS-CoV-2 receptor ACE2, which highlights the importance of the blood-brain barrier (BBB) in preventing virus entry to the brain. In this study, we examine the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) and the cytokine profile in cerebrospinal fluids (CSF) from two patients with a brain tumor and COVID-19. To…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Insights into functional connectivity in mammalian signal transduction pathways by pairwise comparison of protein interaction partners of critical signaling hubs</strong> - Growth factors and cytokines activate signal transduction pathways and regulate gene expression in eukaryotes. Intracellular domains of activated receptors recruit several protein kinases as well as transcription factors that serve as platforms or hubs for the assembly of multi-protein complexes. The signaling hubs involved in a related biologic function often share common interaction proteins and target genes. This functional connectivity suggests that a pairwise comparison of protein…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Docking Study of Several Seconder Metabolites from Medicinal Plants as Potential Inhibitors of COVID-19 Main Protease</strong> - CONCLUSION: Our results obtained from docking studies suggest that pycnamine should be examined in vitro to combat 2019-CoV. Moreover, pycnamine might be a promising lead compound for anti-CoV drugs.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong><em>Withania somnifera</em> (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapy</strong> - Coronavirus disease 2019 (COVID-19) pandemic has killed huge populations throughout the world and acts as a high-risk factor for elderly and young immune-suppressed patients. There is a critical need to build up secure, reliable, and efficient drugs against to the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Bioactive compounds of Ashwagandha [Withania somnifera (L.) Dunal] may implicate as herbal medicine for the management and treatment of patients infected…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesis</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally since December 2019. Several studies reported that SARS-CoV-2 infections may produce false-positive reactions in dengue virus (DENV) serology tests and vice versa. However, it remains unclear whether SARS-CoV-2 and DENV cross-reactive antibodies provide cross-protection against each disease or promote disease severity. In this study, we confirmed that antibodies against the SARS-CoV-2 spike protein and its…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Promising Marine Natural Products for Tackling Viral Outbreaks: A Focus on Possible Targets and Structure-Activity Relationship</strong> - Recently, people worldwide have experienced several outbreaks caused by viruses that have attracted much interest globally, such as HIV, Zika, Ebola, and the one being faced, SARSCoV-2 viruses. Unfortunately, the availability of drugs giving satisfying outcomes in curing those diseases is limited. Therefore, it is necessary to dig deeper to provide compounds that can tackle the causative viruses. Meanwhile, the efforts to explore marine natural products have been gaining great interest as the…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Rise and Fall of Vibes-Based Literacy</strong> - Is a controversial curriculum, entrenched in New York City’s public schools for two decades, finally coming undone? - <a href="https://www.newyorker.com/news/annals-of-education/the-rise-and-fall-of-vibes-based-literacy">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mikhail Gorbachev, the Fundamentally Soviet Man</strong> - The last leader of the U.S.S.R. attempted to modernize and reform his country, even as he failed to imagine it as anything but an empire. - <a href="https://www.newyorker.com/news/postscript/mikhail-gorbachev-the-fundamentally-soviet-man">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biden’s Student-Debt Plan Could Chip Away at the Racial Wealth Gap</strong> - Loan forgiveness and other measures don’t solve the problem of rising tuition costs, but they could help some Black families start to catch up. - <a href="https://www.newyorker.com/news/daily-comment/bidens-student-debt-plan-could-chip-away-at-the-racial-wealth-gap">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Healthy Jobs Report Leaves Republicans Scrambling and Biden Smiling</strong> - After creating 1.1 million jobs since May, the economy has now recovered all the jobs lost to the pandemic. - <a href="https://www.newyorker.com/news/our-columnists/a-healthy-jobs-report-leaves-republicans-scrambling-and-biden-smiling">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dave Grohl and Aimee Mann—Live</strong> - The Foo Fighters front man tells stories from a life of rock and roll. And Mann, a singer-songwriter, discusses her latest album, “Queens of the Summer Hotel.” - <a href="https://www.newyorker.com/podcast/the-new-yorker-radio-hour/dave-grohl-and-aimee-mann-live">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The race to find 2,100 missing species before they go extinct</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/L0sUMyfFJKHfX5crQQ3edgQsE8Q=/0x0:5000x3750/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71320243/20220701mebVOXwater_328.0.jpg"/>
<figcaption>
The widemouth blindcat, a type of catfish, has been missing since the 1980s. If it’s not extinct, it can be found more than 1,000 feet below Earth in the Edwards Aquifer in south-central Texas. | Matthew Busch for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Many animals aren’t endangered or extinct — they’re missing. Species detectives are trying to track them down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4v6QPW">
As a species<strong> </strong>becomes rarer in the environment, it progresses through a series of conservation<strong> </strong>categories — from “vulnerable” to “endangered” to “critically endangered” to “extinct.” You can look up most animals in <a href="https://www.iucnredlist.org/">a database</a> and see which category they fall into. The <a href="https://www.vox.com/science-and-health/22798384/vaquita-extinction-fishing-conservation-mexico">vaquita porpoise</a>, for example, is classified as <a href="https://www.iucnredlist.org/species/17028/214541137">critically endangered</a>, meaning that it’s at risk of extinction. These categories help officials decide which species need protection, and where.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bS6UjS">
But there’s another hugely important category for species that’s often overlooked. It’s simply called “lost.” Scientists use the term to describe plants, animals, and fungi that they haven’t seen for at least 10 years, or by <a href="https://zslpublications.onlinelibrary.wiley.com/doi/full/10.1111/acv.12788">some definitions</a>, 50 years. In many cases, these animals are threatened with extinction — or even already extinct — but no one really knows because they’re missing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EU6BCV">
Scientists are racing to find these lost species, motivated by the idea that they can’t protect what they don’t know exists. And in this week’s episode of <a href="https://www.vox.com/unexplainable"><em>Unexplainable</em></a>, Vox’s podcast that explores big unanswered questions, producer <a href="https://www.vox.com/authors/mandy-nguyen">Mandy Nguyen</a> and I join an expedition that’s hunting for one of them. We search for an eyeless salamander that lives in an aquifer, deep below San Antonio, Texas, which is arguably<strong> </strong>one of the least accessible ecosystems on Earth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AMRLru">
The species hasn’t been seen for more than 70 years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6O2em7">
</p>
<div id="poYtAc">
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cMD9Mp">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Au9XKt">
But the salamander we were after is just one of more than 2,100 lost species, according to the nonprofit group Re:wild, which keeps <a href="https://www.rewild.org/lost-species">a running list</a>. Finding them could be the only thing that prevents them from going extinct — from disappearing for good.
</p>
<h3 id="WVSyko">
Meet some of these “missing” species
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NqyWak">
Lost species are, on the whole, a strange and not-so-charismatic bunch. In some cases, that’s actually why they’re missing — no one has put in the time or effort to find these animals because they don’t attract a lot of attention.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E5cLPG">
The <a href="https://www.vox.com/down-to-earth/23205853/lost-species-extinction-salamander">missing salamander</a> we went searching for in Texas is a prime example. Last seen in 1951, the Blanco blind salamander not only lacks eyes, it’s also colorless, appearing ghostly white, and in order to conserve energy, it rarely moves. It also lives deep underground in the Edwards Aquifer, an underground structure of caves and porous rock that’s full of water (and home to another lost species, the widemouth blindcat, pictured at the top of this story).
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/7658LoH32yt_5I-II_TiSBoJVy0=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23988333/20220701mebVOXwater_52.jpg"/> <cite>Matthew Busch for Vox</cite>
<figcaption>
The only known specimen of the Blanco blind salamander, a lost species that’s been missing for 71 years.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DSHBub">
Still, researchers are desperate to find it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5ByIPy">
Like other salamanders, the species is an indicator of water quality. It’s sensitive to pollution, so where you find the salamander, you can assume the water is relatively clean. This is important because it lives in an aquifer that supplies drinking water to <a href="https://www.nature.org/en-us/about-us/where-we-work/united-states/texas/stories-in-texas/edwards-aquifer-protection/">nearly 2 million people</a> in south-central Texas. Finding the amphibian, or proving it is extinct, would reveal a lot about that critical water source, as I wrote in the feature story below.
</p>
<aside id="kfGQp0">
<div>
</div>
</aside>
<div class="c-float-right">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/jTtVP9vWwAtSuMol0tuxwIFUe00=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23988400/Buller_Kokako.jpeg"/> <cite>J. G. Keulemans, in W.L. Buller’s <em>A History of the Birds of New Zealand</em></cite>
<figcaption>
An illustration of a South Island Kōkako (above) and North Island Kōkako. The South Island Kōkako has been missing for 15 years, and there’s a reward for finding one.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qOt8vF">
Some lost species have been missing for even longer than the salamander. A trapdoor spider native to Europe, for example, hasn’t been seen, definitively, since the early 1900s. An adorable mammal called the Wondiwoi Tree Kangaroo, meanwhile, has been missing since 1928, when it was collected from a forest in Indonesia by the famous evolutionary biologist <a href="https://en.wikipedia.org/wiki/Ernst_Mayr">Ernst Mayr</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BL1JTd">
There are also plants and mushrooms on Re:wild’s <a href="https://www.rewild.org/lost-species/top-25-most-wanted-lost-species">lost species list</a>. Native to the mountains of southern Chile, the big puma fungus hasn’t been seen since 1988, and a type of holly tree endemic to Brazil has been missing for 184 years. (You can find more lost species <a href="https://www.rewild.org/lost-species/top-25-most-wanted-lost-species">here</a>.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jXaZoO">
Like the salamander, many lost species are now the subject of search expeditions, such as Miss Waldron’s Red Colobus Monkey, and some organizations are even <a href="https://www.southislandkokako.org/the-search">offering rewards for finding them</a>.
</p>
<h3 id="RfBZAT">
Who cares about lost species, anyway?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="acvHN0">
The herpetologist Andy Gluesenkamp, who works at the San Antonio Zoo, has spent roughly two decades looking for the Blanco blind salamander, an animal that most people have never heard of, let alone will ever see.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pvxyow">
“It’s my white whale,” he said of the salamander.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1eEu2q">
So what makes researchers like him so keen on finding lost animals?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hfb1dj">
These expeditions contribute to a much bigger scientific mission of understanding what does and does not exist in Earth’s many ecosystems. Documenting life anywhere creates the foundation from which researchers can ask biology’s biggest questions, such as how different animals evolve and why some environments have more diversity than others.
</p>
<div>
<div class="c-image-grid">
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/IEdAN2hu8VIEKgOwHd1jAZUGePk=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23988550/Blog_Feature_Image_globalwildlife_86857900A.jpg"/> <cite>Carlos Vasquez Almazan</cite>
<figcaption>
Jackson’s climbing salamander, once a lost species, was found in 2017 in Guatemala.
</figcaption>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/Whw07zql0O36vppcH_QltPAl1-M=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23988544/Scarlet_Harlequin_Frog_Enrique_La_Marcaa.jpg"/> <cite>Enrique La Marca</cite>
<figcaption>
Native to Venezuela, the Scarlet Harlequin Toad, another lost species, has been missing for 32 years.
</figcaption>
</figure>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8jpyNd">
Right now, we know close to nothing about the Blanco blind salamander, for example, such as where it lives and what it contributes to the aquifer. The only specimen on Earth is in a warehouse in Austin, Texas — and it’s not in great shape. Finding and studying this species in the wild could help answer all kinds of questions about this unique ecosystem and life in extreme environments.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uE0ZDK">
Finding lost species can also help save them from extinction. “We can’t conserve something that we don’t know is there,” said Barney Long, senior director of conservation strategies at Re:wild.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4P6sFB">
And there are already examples of this, which I highlighted in <a href="https://www.vox.com/down-to-earth/23205853/lost-species-extinction-salamander">August:</a>
</p>
<blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9U1D4p">
In 2017, after a park ranger in Guatemala spotted a <a href="https://www.rewild.org/press/found-remarkable-salamander-rediscovery-heralds-early-success-for-worldwide-quest-to-find-and-protect-lost-species">lost species of salamander</a> on the edge of a reserve, Re:wild and other environmental groups helped expand the park’s boundaries to protect the species (which is critically endangered). Two years later, researchers rediscovered a rare <a href="https://www.rewild.org/press/found-chevrotain-miniature-fanged-deer-rediscovered-tiptoeing-through-vietnams-coastal-forests">rabbit-size deer</a> in Vietnam, and have since developed a program to conserve it, including removing hunting snares in the forest.
</p>
</blockquote>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/Sgs9jaEw1aNeLH78yc44bVau10A=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23988548/Blog_Feature_Image_ncs015__ct015__2018_06_21__12_36_23_1___Silver_backed_chevrotaina.jpg"/> <cite>Re:wild/Southern Institute of Ecology/Leibniz Institute for Zoo and Wildlife Research/NCNP</cite>
<figcaption>
A rabbit-size deer called the silver-backed chevrotain, once lost, was <a class="ql-link" href="https://www.rewild.org/lost-species/silver-backed-chevrotain" target="_blank">found</a> in 2019.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wCL8yp">
Lucky for scientists, there are more tools than ever to find missing species. They can use traces of DNA — the <a href="https://www.vox.com/down-to-earth/23205853/lost-species-extinction-salamander">main approach to finding the Blanco blind salamander</a> — or motion-sensing cameras. Ordinary citizens can also get involved, for instance by uploading sightings of animals on a hike to an app like <a href="https://www.inaturalist.org/">iNaturalist</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sQibMq">
“There are so many more technologies out there that are helping us rediscover animals,” Long told me last fall. “Historically, it would have taken months of trudging around wilderness areas to try and find them.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PGHpxi">
If nothing else, finding lost species is about injecting a bit of hope into the movement to conserve wildlife. Normally, <a href="https://www.vox.com/down-to-earth/22700280/extinct-animals-birds-biodiversity-loss">we hear about species that have gone extinct</a>. But not all rare species are extinct; they might just be missing.
</p></li>
<li><strong>Delia Owens wrote the thriller Where the Crawdads Sing. Was she also involved in a murder?</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/f_KsQ8pzm2kgHjmEy2geRZf5w-Q=/97x0:3297x2400/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71320173/option_2.0.jpg"/>
<figcaption>
Cover of <em>Where the Crawdads Sing</em>; Mark and Delia Owens in the North Luangwa National Park in Zambia in 1990. | Penguin Random House; William Campbell/Corbis via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A conservationist, a murder, and a bestselling book.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Okr3Je">
If you’ve visited a bookstore in the past few years, chances are you’ve seen <em>Where the Crawdads Sing</em>’s hazy orange hardcover grace a display shelf or two. The bestselling novel about a murder in a North Carolina marsh by Delia Owens, a former conservationist, has been praised as “<a href="https://www.nytimes.com/2018/08/17/books/review/where-the-crawdads-sing-delia-owens.html">painfully beautiful</a>” by critics. Actress, producer, and Southerner Reese Witherspoon chose the book for her book club. Her production company, Hello Sunshine, adapted it into a 2022 film starring Daisy Edgar-Jones, with Taylor Swift on the soundtrack.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2FZgqF">
But Owens’s career started long before her novel became a huge success. Delia Owens and her ex-husband, Mark Owens, were prominent conservationists, and in the 1990s they lived in Zambia, making it their life’s work to prevent poaching. But in 1995, their methods went a step too far when a suspected poacher was shot and killed. At the time, an ABC News crew was filming a documentary about the Owenses, but they didn’t film the shooter — only the bullets being fired into the man’s body. The couple left Zambia soon afterward and went back home to the United States. They are still wanted for questioning by the Zambian government.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RT2faC">
Fast-forward a couple of decades later, and Delia Owens is now the author of the bestselling book <em>Where the Crawdads Sing</em>. But as journalist and editor-in-chief of the Atlantic Jeff Goldberg tells <a href="https://www.vox.com/today-explained"><em>Today Explained’</em>s</a> Noel King, the book draws on her past life in conservation — and for the past 14 years, he has <a href="https://www.newyorker.com/magazine/2010/04/05/the-hunted">tried to get to the bottom</a> of what happened on that fateful day in 1995.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ncKW4P">
“It just doesn’t seem right that it happened,” Goldberg says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2babTU">
What is Delia Owens’s story, and what does it have in common with her novel that’s sold over 15 million copies? A partial transcript of <a href="https://podcasts.apple.com/us/podcast/it-aint-over-til-the-crawdads-sing/id1346207297?i=1000578072557">their conversation</a>, edited for length and clarity, is below.
</p>
<div id="GUgwzO">
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q93bc8">
</p>
<hr class="p-entry-hr" id="ULahLS"/>
<h4 id="3AQZnt">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V2RdQ9">
Jeff, <a href="https://www.newyorker.com/magazine/2010/04/05/the-hunted">your reporting</a> found that Delia’s husband Mark and his son, Chris, were present the night of the murder. Tell me about how this American couple ended up in Zambia.
</p>
<h4 id="xyV065">
Jeff Goldberg
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JL8VXL">
They had, early in life, decided that they were going to go save the animals in Africa. They were naturalists. They moved first to Botswana, and were very young conservationists, and they wrote a book out of their experience, called <a href="https://www.amazon.com/Cry-Kalahari-Mark-James-Owens/dp/0395647800"><em>The Cry of the Kalahari</em></a><em>, </em>which became quite popular. They went to Zambia. They found this park north of Luangwa — it has great wildlife and these very, very remote parks — and in this particular park north of Luangwa, there was a poaching problem with elephants and rhinos. And they set themselves up there.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VKYpZz">
Over time, Mark got more and more militant in his efforts to fight poaching and would fly nighttime missions. He kept talking about Vietnam. He had never served in Vietnam, but he kept, in books and other talks, talking about it as if it were Vietnam. They were throwing cherry bombs and other things out of planes at night, burning the tents of poaching groups. And as things got darker and darker, [Mark and Delia Owens] started claiming to other people in the region that they were killing poachers, that the scouts under Mark Owens’s command were killing poachers. Delia refers to this in a couple of their books, and she expresses ambivalence about it. But she was part of this operation. She co-ran this operation with Mark Owens. And eventually I think what happened, to put it bluntly, is they became so enamored with it all that they thought, “you know what, we need a lot of publicity for this.” That’s when they invited ABC News in.
</p>
<h4 id="WlVhYM">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Mad4nI">
And that’s how we get to the night when someone kills an alleged poacher, while an ABC News camera is running. Tell me about that night.
</p>
<h4 id="gTFZBt">
Jeff Goldberg
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VgtmR9">
On the night in question, Mark Owens flew an ABC cameraman, a producer, and his son Chris Owens, who was then helping him in this operation, out to an unknown location. We don’t know where it was exactly in the park, but it was on the outskirts of the park, near what they said was an abandoned poacher camp. And at a certain point in the night, an unidentified person came into the camp and was shot.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R2ye32">
This person who is shot — and we can’t really tell — is a Black person, but we don’t know anything about this man’s identity other than that. He’s allegedly a poacher coming into this camp and is on the ground. We can visibly see that he’s moving. So he’s wounded, he’s not dead. Then there are three more shots from off camera.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aWVjc5">
The camera doesn’t pivot to show us who the shooter is. We don’t see who is firing, but the bullets are fired into this body.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nCjQXf">
And that’s the last we see of this. My investigation, 13, 14 years ago, learned that the shots from off camera were fired by Chris Owens. The person who told me that was the ABC cameraman. Chris Everson is a South African cameraman and very prominent journalist. Chris Owens disappeared from the camp, witnesses told me after that, and was sent out to America. He’s never been back to Zambia. Nobody calls the authorities.
</p>
<h4 id="fRxqsh">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Qe62zu">
Can I ask you about the moment you realize this woman whose trail you’ve been on for many years has written a book that is in Reese Witherspoon’s book club. What the hell was that like?
</p>
<h4 id="H5ioTm">
Jeff Goldberg
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VZMb8I">
It started with one or two emails from people who remembered my <a href="https://www.newyorker.com/magazine/2010/04/05/the-hunted">New Yorker piece from 2010</a> who said, “Hey, I don’t know if you know this, but Delia Owens is on the New York Times Best Seller list.” And so it piqued my curiosity. I went out and got the book and — this is the strange part — the book is kind of Edgar Allan Poe-ish in a certain way. There are all these hints and allusions to earlier dark events in Zambia. I mean, spoiler alert, to the extent that there’s anybody in America who doesn’t know what this book is about, the book is about a strange, awkward, loner, naturalist Southern girl who commits a described-as-righteous murder in what would in the African context be known as the bush, and what in the American context would be known as the wilderness or the swamps or whatever.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EasU5h">
And I’m reading it and I’m going, “Oh, my goodness<em>.”</em> And by the way, it makes references to people that they knew in Zambia. I mean, the name of the jailhouse cat is Sunday Justice, which is the name of their cook and aide in their camp in North Luangwa. A guy I met. And I come across that, I’m like, “Oh my goodness<em>.”</em> Not to make this self-referential, but I thought she was trolling me from a distance kind of way. I was like, “Why are you planting all these clues? Why are you doing this?”
</p>
<h4 id="7dtTYy">
Noel King
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YegSST">
At the end of the day, Jeff, what would you like to happen here? What do you think justice would look like? Is justice what you want? Or do you just want to keep chasing the Owenses around the world?
</p>
<h4 id="13fviR">
Jeff Goldberg
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="putSVJ">
No, I don’t. I had done my thing 12 years ago, wrote my piece, put it out in the world. Thank you very much, on to the next thing. You know, I’ll tell you what bothers me. What bothers me is the idea that somebody was murdered in a remote part of Zambia, a remote part of Africa, and no one cares.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Bc0hG">
I would like to know who the person was. It was a male. Probably had a family, disappeared into the bush. If the body was dumped in a lagoon, it means it was eaten by crocodiles. It doesn’t seem right, is my point. It just doesn’t seem right that this happened. And I include ABC News in the category of people who have done wrong things here because they were just out looking for some violence, right? And they know what happened.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1MuOLZ">
And Chris Everson, the ABC News cameraman, his conscience obviously was bothering him when I called him in South Africa. He told me what happened. He didn’t say “no comment.” He didn’t say, “I have no idea what you’re talking about.” He didn’t lie. He told me the truth. He said, “This is a terrible thing that happened. And I saw it.” And it was almost like he was waiting for years for somebody to call him, and I just think it’s wrong. And I know that some combination of Mark, Chris, and Delia Owens know exactly what happened to this person and they know where the body was taken. And that just doesn’t seem right.
</p></li>
<li><strong>You’re being tracked through your email. Here’s how to stop it.</strong> -
<figure>
<img alt="Cartoon image of a hacker sitting at a laptop across from an unsuspecting victim, also at a laptop." src="https://cdn.vox-cdn.com/thumbor/L9HUo1t9IZUMJVsnTf9BCY-pgCg=/0x0:6667x5000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71320137/GettyImages_1302958644.0.jpg"/>
<figcaption>
Denis Novikov/Getty Images/iStockphoto
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It’s time to turn off those secret email read receipts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LlD6VR">
I subscribe to a lot of newsletters. I read most of them, too. But their authors wouldn’t know it because I’ve disabled the trackers that detect and tell the senders when subscribers open their emails. It’s nothing personal; I just don’t want anyone knowing what I read, when, how many times I read it, the device I read it on, and even where I was when I read it. How about you?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VA92J9">
Oh, you didn’t know it was possible for email senders to know all of that about you just because you clicked open? It <a href="https://www.eff.org/deeplinks/2019/01/stop-tracking-my-emails">very much is</a>, and <a href="https://senglehardt.com/papers/pets18_email_tracking.pdf">it happens a lot</a> — in newsletters and marketing emails especially. But trackers aren’t limited to them. Anyone can sneak a tracker into your email; services that do this are <a href="https://mailtrap.io/blog/free-email-tracking-tools/">plentiful and free</a>. If you’re the kind of person who turns off read receipts on texts and DMs, this is probably not good news to read.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f4lOya">
While it’s creepy to think of your email reading habits being tracked, that’s not the only reason why you should consider taking a few extra steps to protect your email. Your email address has become one of your <a href="https://www.vox.com/recode/22620276/what-to-do-when-you-get-someone-elses-email-security-vulnerabilities-gmail-inbox-invasion">best and most persistent identifiers</a>, and data brokers and marketers will match what you do with it in one place with what you’ve used it for in others. That helps them build an ever-more-comprehensive profile of your online (and offline) life. You might be fine with getting emails from the store you gave your address to, or even that store knowing whether you opened their emails. You might not be so fine with a bunch of other companies you have no relationship with knowing it, too. But that’s exactly what happens.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WJsCas">
There’s also the security factor. Emails get leaked in data breaches <a href="https://haveibeenpwned.com/">all the time</a>, and there’s a lot a determined hacker can do with your email address, especially since email addresses often double as logins. If a company doesn’t have your real email address, that’s one less thing you have to worry about getting out there if (or, really, <a href="https://www.vox.com/the-goods/23031858/data-breach-data-loss-personal-consequences">when</a>) that company gets hacked.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lGn2wN">
The good news is there are ways to better protect your email privacy. A new one just dropped: DuckDuckGo, the <a href="https://www.vox.com/recode/22981115/duckduckgo-free-speech-privacy-oops">privacy-first</a> search engine provider, just opened up its <a href="https://duckduckgo.com/email/">Email Protection</a> service after a year of beta testing. Apple, Firefox, and Proton have similar offerings, each with its own pros and cons.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VARiHk">
Here are a few services and ways to make your email more private and why you should consider using them. These aren’t the only companies offering these services, but they each have a reputation for protecting their users’ privacy. In some cases, that’s their mission statement.
</p>
<h3 id="V0Zs75">
Disguise your email address
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kAccOR">
One of the best ways to protect your email privacy is also one of the most obvious: Don’t give your email address out in the first place. But email addresses are valuable, so companies will do whatever they can to get them. Maybe they’ll require you to give them your email address if you want to order anything, or they’ll dangle a nice juicy discount in front of you in exchange for it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wH7saa">
One solution is to use a service that gives you an alias email address, which redirects messages to the inbox of your choice. That way, you can get all the emails (and coupons) in your real inbox without the senders knowing what your real address is.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XovpKU">
Perhaps the best-known example of this is Apple’s “<a href="https://support.apple.com/en-us/HT210425">Hide My Email</a>” feature. I use this, so I can tell you that it works as promised. I get unlimited aliases and use a different one everywhere. But, as seems to be the case with everything Apple, it works much better within the Apple ecosystem than it does outside of it. If you’re logged into your iCloud account, using an Apple device, going through Apple’s Safari browser, or using <a href="https://support.apple.com/en-us/HT210318">sign in with Apple</a>, then Hide My Email will pop up as an option at email prompts. Creating and entering your fake email address is about as easy as entering your real one.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GEUfUl">
But if you’re using a non-Apple product or service, the process becomes significantly more time-consuming and annoying. Another drawback is that it costs money. You have to have an iCloud+ account, which starts at 99 cents a month and includes other things, like expanded cloud storage. So while Hide My Email is a good feature for some, it’s probably not the best option for all.
</p>
<div class="c-float-right">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/2Tv6txoMN4GSg5SzpKe_URpi7ro=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23989254/IMG_9723.jpg"/>
<figcaption>
DuckDuckGo’s Email Protection makes it easy to create fake email addresses.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SCt84F">
DuckDuckGo’s Email Protection, on the other hand, is free. And it’s available on most web browsers if you install DuckDuckGo’s extension, which you can get through DuckDuckGo’s site or your browser’s extension store (the notable exception being Safari, though DuckDuckGo says that’s in the works). After that, it’ll pop up automatically as an option whenever there’s an email prompt, similar to Hide My Mail. You get as many aliases as you want, set-up is simple, and it’s got a few other features that I’ll get into later.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WnktzW">
There’s also <a href="https://relay.firefox.com">Firefox Relay</a>, which has a free and a paid option. The free one only gives you 5 aliases, while the paid tier has unlimited addresses. It’s 99 cents a month, though Firefox says that price point will only be available for a limited time. Also, the browser extension you’ll need to easily use Relay in email prompts isn’t available on all browsers. Finally, you have to have or create a Firefox account to use it. That’s easy enough to do, but it’s also an extra step you may not want to take when signing up for a service that’s supposed to help you avoid giving away your data while setting up accounts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o993Ra">
Finally, Proton — which is best known for its encrypted email service — <a href="https://proton.me/support/creating-aliases">now offers</a> the ability to create alias email addresses with paid Proton Mail plans, which start at $3.99 a month. The cheapest option only gives you 10 aliases, though, so if you’re planning on using a different email for everything, that won’t be enough.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EXkS3U">
If you don’t want to bother with going through an alias service, you can always just create your own alternate account on whatever email provider you use and put that down for all the things you don’t want to give out your real email address for. It’ll reduce the amount of junk email you get in your real inbox, but if you use that one email address enough times in enough places, it’ll become just as much of an identifier of you as your real email address is.
</p>
<h3 id="AWrxer">
Block those trackers
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qegh7Z">
Whether you’re giving out your real email address or going through an alias, you may not want email senders to know if and when you read their messages. They can <a href="https://www.hubspot.com/sales/email-tracking-guide">learn a lot</a> about you just from that. This tracking happens through tiny little images — a pixel, basically — embedded in the email. When you open the email, it makes a call to the server the image is hosted on, which tells the tracking service that you opened the email, how many times you opened it, when you opened it, some info about the device you used to open it, and possibly even your IP address (many email providers have cut this off; Gmail, for instance, routes image requests through its servers, which masks your IP address).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bCYSCi">
Some of the same companies that offer email aliases also have tracker blocking services. Apple rolled out its tracker blocking feature, Mail Privacy Protection, last year with iOS15. The good news is Mail Privacy Protection is free and easy to enable — either you got a prompt the first time you opened Mail asking if you wanted to turn it on, or it’s a matter of finding it in your settings. The bad news is it only works in Apple’s Mail app.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xYk3it">
Proton’s mail service <a href="https://proton.me/blog/enhanced-tracking-protection">enables tracker protection</a> by default and is available with both its free and paid tiers. It’ll tell you which trackers it blocked and who they’re from, giving you a chance to sort of spy on the companies spying on you. But tracker protection is only available on Proton’s website. Proton says it’s coming to the mobile app soon.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RMLvvP">
DuckDuckGo’s Email Protection service is not tied to any one company or operating system. It detects and filters out trackers before they make their way to your (real) inbox. It also removes trackers from links with the emails, and it’ll let you know if an email contained trackers and who they’re from. Just to give you a sense of how pervasive these trackers are: DuckDuckGo says about 85 percent of the emails that passed through its new service during Email Protection’s beta phase contained trackers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pIezN8">
Firefox Relay’s free and premium tiers also remove trackers. Note that both DuckDuckGo and Firefox’s options only remove trackers from the emails that pass through them; that is, the emails coming through the alias emails you created with their services. They’re not removing trackers from emails that go directly to your real email address.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2YP670">
Finally, you can always go the DIY route by going into your email settings and making sure that you’ve chosen not to automatically download images. In Gmail, for instance, you can do this by going to Settings <strong>&gt; </strong>General <strong>&gt; </strong>Images <strong>&gt; </strong>Ask before displaying external images. The downside of this method is that your emails might look like a sea of broken image icons, since you’re not just blocking trackers, you’re blocking all images hosted externally, even if they’re perfectly harmless.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kNhMUs">
A final note: While these services and techniques will surely protect your privacy to some extent, nothing is foolproof. If there’s any identifying information attached to your alias email address — maybe you set up an account using it and then order something to be delivered to your real physical address using your real name — it won’t be hard for a data broker to match it back to you. While tracker blockers are effective, there’s always a chance that marketers and the tracking services they use will come up with another way to track you through your emails. And then we’ll start the whole process of figuring out how to block those trackers all over again.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Theon excels</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nagada, Angel Heart, Star Romance and Proposed please</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Once You Go Black, The Sovereign Orb, Trevalius, Albinus and Forest Flame impress</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sehajpreet scores six goals</strong> - Special Correspondent</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Shocked by high level of political interference in AIFF elections: Bhutia</strong> - Rajasthan State Association President Manvendra Singh had alleged that Law Minister Kiren Rijiju was at the hotel where the AIFF members stayed and told them to vote against Bhaichung Bhutia in the AIFF president elections</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra Pradesh: Child rights panel to act tough against schools violating RTE Act</strong> - Recognised private and unaided schools are mandated to allot 25% seats to EWS students under the Act, says APSCPCR Chairman</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘Minimally invasive treatment standard option for heart diseases’</strong> - Annual conference of Interventional Cardiology Council begins</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Twitter war erupts between BJP MP Nishikant Dubey, Deoghar DC over entry into airport ATC</strong> - An FIR was registered against nine people, including BJP MPs Nishikant Dubey and Manoj Tiwari, for allegedly forcing Air Traffic Control officials to provide clearance for their chartered flight.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ghulam Nabi Azad to hold first rally after quitting Congress in Jammu</strong> - Ex-Congress leader’s September 3 rally to focus on jobs, land safeguards; he may not seek ‘reversing the clock’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Merchandise exports remain flat at $33 billion in August</strong> - On conservating estimate, exports will cross $750 billion amid global headwinds, said Commerce Secretary</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Russia to keep key gas pipeline to EU closed</strong> - Russia says it has found a leak on Nord Stream 1, but the EU accuses Moscow of using gas as a weapon.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: G7 agrees to impose price cap on Russian oil</strong> - Members of the Group of Seven say the move will hurt Russia’s ability to finance its war on Ukraine.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gibraltar collision: Race to remove fuel from stricken ship</strong> - Salvage teams rush to remove hundreds of tonnes of fuel from the ship amid fears of ecological damage.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UN FAO’s global food prices fall for fifth month in a row</strong> - The UN FAO’s food prices index has fallen to a lower level than before Russia invaded Ukraine.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Earthquake rocks Liechtenstein Parliament… during earthquake debate</strong> - The moment a tremor hits the Liechtenstein Parliament building causing the session to be paused.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Liveblog: All the news from Apple’s “Far Out” event</strong> - Tune in at 1 pm EST on September 7, 2022, to see what’s next from Apple. - <a href="https://arstechnica.com/?p=1877934">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How a giant eagle came to dominate ancient New Zealand</strong> - Evidence suggests eagle was part of a wave of feathered invaders. - <a href="https://arstechnica.com/?p=1877987">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>After careful consideration, NASA ready to launch SLS rocket as is</strong> - “There’s no guarantee we’re going to get off on Saturday.” - <a href="https://arstechnica.com/?p=1877890">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>YouTube algorithm pushed election fraud claims to Trump supporters, report says</strong> - Researchers analyzed real recommendations to hundreds of YouTube users. - <a href="https://arstechnica.com/?p=1878094">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Here come the bendable TVs and monitors that no one asked for</strong> - Flat-to-curved screens have an identity crisis. - <a href="https://arstechnica.com/?p=1877958">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>What do you call a Muslim-friendly joke?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Halol
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/useless_switch"> /u/useless_switch </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/x4pjin/what_do_you_call_a_muslimfriendly_joke/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/x4pjin/what_do_you_call_a_muslimfriendly_joke/">[comments]</a></span></p></li>
<li><strong>My daughter wants a pet spider for her birthday</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I went to the pet store, and the owner said “that’ll be $200 please”, I said “$200? It’ll be cheaper getting one off the web”.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/AutumnalAristocrat"> /u/AutumnalAristocrat </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/x46ljy/my_daughter_wants_a_pet_spider_for_her_birthday/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/x46ljy/my_daughter_wants_a_pet_spider_for_her_birthday/">[comments]</a></span></p></li>
<li><strong>I like my women how I like my COVID</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
19, breathtaking, and easy to spread
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/leathco"> /u/leathco </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/x49arh/i_like_my_women_how_i_like_my_covid/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/x49arh/i_like_my_women_how_i_like_my_covid/">[comments]</a></span></p></li>
<li><strong>Who is the most popular guy at a nudist colony?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The guy who can carry half a dozen donuts and two cups of coffee.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Who’s the mist popular girl? The one that can eat the last donut…
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Kaptain_Karnage"> /u/Kaptain_Karnage </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/x4qbru/who_is_the_most_popular_guy_at_a_nudist_colony/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/x4qbru/who_is_the_most_popular_guy_at_a_nudist_colony/">[comments]</a></span></p></li>
<li><strong>Beautiful redhead</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
This guy is dining alone in a fancy restaurant and there’s a beautiful redhead sitting at the next table. He’s been sneakily checking her out ever since he arrived, but doesn’t have the courage to start talking to her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Suddenly she sneezes, and her glass eye comes flying out of its socket toward the man. His reflexes kick in and he reaches out, plucks it out of the air, and hands it back to her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The redhead is mortified. “Oh my, I am so sorry,” she says as she pops her eye back into place. “Let me buy your dinner to make it up to you.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
So he joins her table and they enjoy a wonderful meal together. Afterwards they go to the theatre followed by drinks at a bar. They talk, they laugh, she shares her deepest dreams and he shares his. She listens.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After paying for everything, she asks him if he would like to come to her place for a nightcap. He says yes and they return to her place.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He ends up staying the night. The next morning, she cooks a gourmet meal with all the trimmings. The guy is amazed at how everything has been so perfect and how incredible this woman is. He can’t believe his luck. “You know,” he said, “you are the perfect woman, are you this nice to every guy you meet?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“No,” she replies, “You just happened to catch my eye.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/mercaptopurine"> /u/mercaptopurine </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/x4gnqk/beautiful_redhead/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/x4gnqk/beautiful_redhead/">[comments]</a></span></p></li>
</ul>
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