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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Psychological distance towards COVID-19: Geographical and hypothetical distance predict attitudes and mediate knowledge</strong> -
<div>
While different antecedents have been examined to explain peoples’ reactions towards COVID-19, there is only scarce understanding about the role of the subjective closeness and distance to the pandemic. Within the current study, we applied the concept of psychological distance to understand the distance towards COVID-19 and investigated its (1) connection with preventive attitudes and proactive behaviors, (2) context-specific antecedents, and its (3) mediating effect of knowledge on attitudes. Using an online sample from a German quantitative cross-sectional study (N = 395, M = 32.2 years, SD = 13.9 years, 64.3% female) in July 2020, a time with a general low incidence of people infected with Sars-CoV2, we measured relevant socio-psychological constructs addressing COVID-19 and included further information from external sources. Based on a path model, we found geographical distance as a significant predictor of cognitive attitudes towards COVID-19. Furthermore, hypothetical distance (i.e., feeling to be likely affected by COVID-19) predicted not only participants’ affective, cognitive, and behavioral attitudes, but also the installation of a corona warning-app. While several variables affected the different dimensions of psychological distance, hypothetical and geographical distance mediated the effect of knowledge on attitudes. These results underline the role of geographical and hypothetical distance for health-related behaviors and education. For example, people will only comply with preventive measures if they feel geographically concerned by the disease, which is particularly challenging for fast-spreading global diseases such as COVID-19. Therefore, there is a need to clearly communicate the personal risks of diseases and address peoples’ hypothetical distance.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/3n5pt/" target="_blank">Psychological distance towards COVID-19: Geographical and hypothetical distance predict attitudes and mediate knowledge</a>
</div></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vaccine-induced humoral and cellular immunity against SARS-CoV-2 at 6 months post BNT162b2 vaccination</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
To evaluate vaccine-induced humoral and cell-mediated immunity at 6 months post BNT162b2 vaccination, immunoglobulin G against SARS-CoV-2 spike protein (SP IgG), 50% neutralizing antibody (NT50), and spot-forming cell (SFC) counts were evaluated by interferon-γ releasing ELISpot assay of 98 healthy subjects (median age, 43 years). The geometric mean titers of SP IgG and NT50 decreased from 95.2 (95% confidence interval (CI) 79.8-113.4) to 5.7 (95% CI 4.9-6.7) and from 680.4 (588.0-787.2) to 130.4 (95% CI 104.2-163.1), respectively, at 3 weeks and 6 months after the vaccination. SP IgG titer was negatively correlated with age and alcohol consumption. Spot-forming cell counts at 6 months did not correlate with age, gender, and other parameters of the patients. SP IgG, NT50, and SFC titers were elevated in the breakthrough infected subjects. Although the levels of vaccine-induced antibodies dramatically declined at 6 months after vaccination, a certain degree of cellular immunity was observed irrespective of the age.
</p>
</div></li>
</ul>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.30.21265693v1" target="_blank">Vaccine-induced humoral and cellular immunity against SARS-CoV-2 at 6 months post BNT162b2 vaccination</a>
</div>
<ul>
<li><strong>Vaccination and partisanship during Covid-19 in England</strong> -
<div>
An emerging literature documents the presence of large partisan differences in the views and behaviours of different voters towards the Covid-19 pandemic. How does this affect vaccination rates? We address this question in the case of England using a cross-sectional regression analysis of constituency level vaccination data in October 2021 matched with the latest General Election results in England. Our results show that partisanship is crucial to account for differences across English constituencies. We find a positive and robust association between the share of Conservative voters and vaccination rates in different constituencies. This effect holds when controlling for differences in house prices and wages, population composition, the health and deprivation of the constituency and past austerity, and when rerunning the analysis on vaccination rates for different age groups. Our results contrast with studies of beliefs about Covid-19 and compliance with national lockdowns in England, where Conservative voter appear more sceptic, but also with the US where Republican States and individuals tend to vaccinate less.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/wf6ns/" target="_blank">Vaccination and partisanship during Covid-19 in England</a>
</div></li>
<li><strong>Parents perceptions and intention to vaccinate their children against COVID-19: Results from a cross-sectional national survey in India</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background Despite the success of adult vaccination against COVID-19, providing vaccines to children remains a challenge for policymakers globally. As parents are primary decision-makers for their children, we aimed to assess parents perceptions and intentions regarding COVID-19 vaccination in India. Methods A cross-sectional web-based study was designed, parents or caregivers (N=770) were recruited through snowball sampling using Google form. Cross- tabulation was performed by parents intention to vaccinate their children against COVID-19 virus with sociodemographic characteristics and their risk perception towards COVID-19, trust in the healthcare system, and their history of vaccine hesitancy behavior. Multivariable logistic regression analysis was performed to compute the predictors of child vaccination intention among Indian parents. Results Seven hundred seventy parents across the country have completed the survey. Of the 770 participants, 258 (33.5%) have shown intent to vaccinate their children. The stated likelihood of child vaccination was greater among parents who had a bachelors degree or higher education (aOR: 1.98, 95% CI: 1.15-3.51); as well as among parents who intended to vaccinate themselves (aOR: 2.35, 95% CI: 1.30-4.67). Parental concerns centered around vaccine safety and side effects. Conclusion Indian parents reported high knowledge of the COVID-19 virus and were aware of the development of a novel vaccine. However, about one-third of parents intended to vaccinate their children, and about half of them were not sure whether to vaccinate their children or not against the COVID-19 virus. The study highlighted the need for health promotion strategies that promote vaccine uptake among parents.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.30.21265449v1" target="_blank">Parents perceptions and intention to vaccinate their children against COVID-19: Results from a cross-sectional national survey in India</a>
</div></li>
<li><strong>Measuring College Student Attitudes Toward COVID-19 Vaccinations</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
This survey explores attitudes of 1,197 currently enrolled college students regarding their comfort taking a COVID-19 vaccine. Results suggest most college students are willing to take a COVID-19 vaccine if their institution requires it to return to campus in subsequent semesters. However, certain students of Color, students with disabilities, and adult students may be less willing to take a COVID-19 vaccine if it were required before or during an on-campus semester. Finally, many college students do not understand that COVID-19 vaccines will be free, possibly affecting student willingness to vaccinate and their perceptions of safely and affordably returning to campus. Implications for postsecondary policy and leadership are addressed.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.30.21265699v1" target="_blank">Measuring College Student Attitudes Toward COVID-19 Vaccinations</a>
</div></li>
<li><strong>Assessment of the fatality rate and transmissibility taking account of undetected cases during an unprecedented COVID-19 surge in Taiwan</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background During the COVID-19 outbreak in Taiwan between May 11 and June 20, 2021, the observed fatality rate (FR) was 5.3%, higher than the global average at 2.1%. The high number of reported deaths suggests that hospital capacity was insufficient. However, many unexplained deaths were subsequently identified as cases, indicating that there were a few undetected cases, hence resulting in a higher estimate of FR. Knowing the number of total infected cases can allow an accurate estimation of the fatality rate (FR) and effective reproduction number (R<sub>t</sub>). Methods After adjusting for reporting delays, we estimated the number of undetected cases using reported deaths that were and were not previously detected. The daily FR and R<sub>t</sub> were calculated using the number of total cases (i.e. including undetected cases). A logistic regression model was developed to predict the detection ratio among deaths using selected predictors from daily testing and tracing data. Results The estimated true daily case number at the peak of the outbreak on May 22 was 897, which was 24.3% higher than the reported number, but the difference became less than 4% on June 9 and afterward. After taking account of undetected cases, our estimated mean FR (4.7%) was still high but the daily rate showed a large decrease from 6.5% on May 19 to 2.8% on June 6. R<sub>t</sub> reached a maximum value of 6.4 on May 11, compared to 6.0 estimated using the reported case number. The decreasing proportion of undetected cases was associated with the increases in the ratio of the number of tests conducted to reported cases, and the proportion of cases that are contact-traced before symptom onset. Conclusions Increasing testing capacity and tracing efficiency can lead to a reduction of hidden cases and hence improvement in epidemiological parameter estimation.
</p>
</div>
<div class="article- link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.29.21265691v1" target="_blank">Assessment of the fatality rate and transmissibility taking account of undetected cases during an unprecedented COVID-19 surge in Taiwan</a>
</div></li>
<li><strong>Label-Free SARS-CoV-2 Detection on Flexible Substrates</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
One of the most important strategies for mitigation and managing pandemics is widespread, rapid and inexpensive testing and isolation of infected patients. In this study, we demonstrate large area, label-free, and rapid testing sensor platforms fabricated on both rigid and flexible substrates for fast and accurate detection of SARS-CoV-2. SERS enhancing metal insulator metal (MIM) nanostructures are modeled using finite element simulations and then fabricated using nanoimprint lithography (NIL) and transfer printing. The SERS signal of various viral samples, including spiked saliva, was analyzed using machine learning classifiers. We observe that our approach can obtain the test results typically within 25 minutes with a detection accuracy of at least 83% for the viral samples. We envision that this approach which features large area nanopatterning, fabrication in both rigid and flexible formats for wearables, SERS spectroscopy and machine learning can enable new types of rapid, label-free biosensors for screening pathogens and managing current and future pandemics.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.29.21265683v1" target="_blank">Label-Free SARS-CoV-2 Detection on Flexible Substrates</a>
</div></li>
<li><strong>Multi-ethnic Investigation of Risk and Immune Determinants of COVID-19 Outcomes</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives: To compare risk factors for COVID-19 mortality among hospitalized Hispanic, Non-Hispanic Black, and White patients. Design: Retrospecitve cohort study Setting: Five hosptials within a single academic health system Participants: 3,086 adult patients with self-reported race/ethnicity information presenting to the emergency department and hospitalized with COVID-19 up to April 13, 2020. Main outcome measures: In-hospital mortality Results: While older age (multivariable OR 1.06, 95% CI 1.05-1.07) and baseline hypoxia (multivariable OR 2.71, 95% CI 2.17-3.36) were associated with increased mortality overall and across all races/ethnicities, Non-Hispanic Black (median age 67, IQR 58-76) and Hispanic (median age 63, IQR 50-74) patients were younger and had different comorbidity profiles compared to Non-Hispanic White patients (median age 73, IQR 62-84; p&lt;0.05 for both comparisons). Among inflammatory markers associated with COVID-19 mortality, there was a significant interaction between the Non-Hispanic Black population and interleukin-1-beta (interaction p-value 0.04). Conclusions: This analysis of a multi-ethnic cohort highlights the need for inclusion and consideration of diverse popualtions in ongoing COVID-19 trials targeting inflammatory cytokines.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.29.21265687v1" target="_blank">Multi-ethnic Investigation of Risk and Immune Determinants of COVID-19 Outcomes</a>
</div></li>
<li><strong>Contributions of occupation characteristics and educational attainment to racial/ethnic inequities in COVID-19 mortality</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Racial/ethnic inequities in COVID-19 mortality are hypothesized to be driven by education and occupation, but limited empirical evidence has assessed these mechanisms. Objective: To quantify the extent to which educational attainment and occupation explain racial/ethnic inequities in COVID-19 mortality. Design: Observational cohort. Setting: California. Participants: Californians aged 18-65 years. Measurements: We linked all COVID-19-confirmed deaths in California through February 12, 2021 (N=14,783), to population estimates within strata defined by race/ethnicity, sex, age, USA nativity, region of residence, education, and occupation. We characterized occupations using measures related to COVID-19 exposure including essential sector, telework-ability, and wages. Using sex- stratified regressions, we predicted COVID-19 mortality by race/ethnicity if all races/ethnicities had the same education and occupation distribution as White people and if all people held the safest educational/occupational positions. Results: COVID-19 mortality per 100,000 ranged from 15 for White and Asian females to 139 for Latinx males. Accounting for differences in age, nativity, and region, if all races/ethnicities had the education and occupation distribution of Whites, COVID-19 mortality would be reduced for Latinx males (-22%) and females (-23%), and Black males (-1%) and females (-8%), but increased for Asian males (+22%) and females (+23%). Additionally, if all individuals had the COVID-19 mortality associated with the safest educational and occupational position (Bachelor9s degree, non-essential, telework, highest wage quintile), there would have been 57% fewer COVID-19 deaths. Conclusion: Educational and occupational disadvantage are important risk factors for COVID-19 mortality across all racial/ethnic groups, especially Latinx individuals. Eliminating avoidable excess risk associated with low-education, essential, on- site, and low-wage jobs may reduce COVID-19 mortality and inequities, but is unlikely to be sufficient to achieve equity.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.29.21265628v1" target="_blank">Contributions of occupation characteristics and educational attainment to racial/ethnic inequities in COVID-19 mortality</a>
</div></li>
<li><strong>An Objective Search for Unrecognized Bias in Validated COVID-19 Prediction Models</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The growing recognition of algorithmic bias has spurred discussions about fairness in artificial intelligence (AI) / machine learning (ML) algorithms. The increasing translation of predictive models into clinical practice brings an increased risk of direct harm from algorithmic bias; however, bias remains incompletely measured in many medical AI applications. Using data from over 56 thousand Mass General Brigham (MGB) patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we evaluate unrecognized bias in four AI models developed during the early months of the pandemic in Boston, Massachusetts that predict risks of hospital admission, ICU admission, mechanical ventilation, and death after a SARS-CoV-2 infection purely based on their pre-infection longitudinal medical records. We discuss that while a model can be biased against certain protected groups (i.e., perform worse) in certain tasks, it can be at the same time biased towards another protected group (i.e., perform better). As such, current bias evaluation studies may lack a full depiction of the variable effects of a model on its subpopulations. If the goal is to make a change in a positive way, the underlying roots of bias need to be fully explored in medical AI. Only a holistic evaluation, a diligent search for unrecognized bias, can provide enough information for an unbiased judgment of AI bias that can invigorate follow-up investigations on identifying the underlying roots of bias and ultimately make a change.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.28.21265629v1" target="_blank">An Objective Search for Unrecognized Bias in Validated COVID-19 Prediction Models</a>
</div></li>
<li><strong>COVID-19 Vaccine Failure in Chronic Lymphocytic Leukemia and Monoclonal B-Lymphocytosis; Humoral and Cellular Immunity</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Chronic lymphocytic leukemia (CLL) is associated with immunocompromise and high risk of severe COVID-19 disease and mortality. Monoclonal B-Lymphocytosis (MBL) patients also have immune impairment. We evaluated humoral and cellular immune responses in 181 patients with CLL (160) and MBL (21) to correlate failed seroconversion (&lt;50AU/mL SARS-CoV-2 II IgG assay, antibody to spike protein, Abbott Diagnostics) following each of 2 vaccine doses with clinical and laboratory parameters. Following first and second doses, 79.2% then 45% of CLL, and 50% then 9.5% of MBL respectively remained seronegative, indicating 2 vaccine doses are crucial. There was significant association between post-dose 2 antibody level with pre-vaccination reduced IgM (p&lt;0.0001), IgG2 (p&lt;0.035), IgG3 (p&lt;0.046), and CLL therapy within 12 months (p&lt;0.001) in univariate analysis. By multivariate analysis, reduced IgM (p&lt;0.0002) and active therapy (p&lt;0.0002) retained significance. There was no significant correlation with age, gender, CLL duration, IgG, IgA or lymphocyte subsets. Anti-spike protein levels varied widely and were lower in CLL, than MBL, and both lower than normal donors. Neutralization activity showed anti-spike levels &lt;1000AU/mL were usually negative for both an early viral clade and the contemporary Delta variant. There were 72.9% of CLL and 53.3% of MBL who failed to reach anti-spike levels &gt;1000AU/mL. In a representative subset of 32 CLL patients, 80% had normal T-cell responses by IFNγ and IL-2 FluoroSpot assay. Failed seroconversion occurred in 36.6%% of treatment-naive patients, 52.9% treatment-naive with reduced IgM, 78.1% on therapy, and 85.7% on ibrutinib. Vaccination failure is very common in CLL, including early-stage disease.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.28.21265549v1" target="_blank">COVID-19 Vaccine Failure in Chronic Lymphocytic Leukemia and Monoclonal B-Lymphocytosis; Humoral and Cellular Immunity</a>
</div></li>
<li><strong>Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 Vaccines in Hong Kong</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background. Few head-to-head evaluations of immune responses to difference vaccines have been reported. Methods. Surrogate virus neutralization test (sVNT) antibody levels of adults receiving either 2 doses of BNT162b2 (n=366) or CoronaVac (n=360) vaccines in Hong Kong were determined. An age-matched subgroup (BNT162b2 (n=49) vs CoronaVac (n=49)) were tested for plaque reduction neutralizing (PRNT) and spike binding antibody and T cell reactivity in peripheral blood mononuclear cells (PBMC). Findings. One month after the second dose of vaccine, BNT162b2 elicited significantly higher PRNT50, PRNT90, sVNT, spike receptor binding, spike N terminal domain binding, spike S2 domain binding, spike FcR binding and antibody avidity levels than CoronaVac. The geometric mean PRNT50 titres in those vaccinated with BNT162b2 and CoronaVac vaccines were 251.6 and 69.45 while PRNT90 titres were 98.91 and 16.57, respectively. All of those vaccinated with BNT162b2 and 45 (91.8%) of 49 vaccinated with CoronaVac achieved the 50% protection threshold for PRNT90. Allowing for an expected seven-fold waning of antibody titres over six months for those receiving CoronaVac, only 16.3% would meet the 50% protection threshold versus 79.6% of BNT162b2 vaccinees. Age was negatively correlated with PRNT90 antibody titres. Both vaccines induced SARS-CoV-2 specific CD4+ and CD8+ T cell responses at 1-month post-vaccination but CoronaVac elicited significantly higher structural protein-specific CD4+ and CD8+ T cell responses. Conclusion. Vaccination with BNT162b2 induces stronger humoral responses than CoronaVac. CoronaVac induce higher CD4+ and CD8+ T cell responses to the structural protein than BNT162b2.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.28.21265635v1" target="_blank">Comparison of the immunogenicity of BNT162b2 and CoronaVac COVID-19 Vaccines in Hong Kong</a>
</div></li>
<li><strong>Vaccination of COVID-19 Convalescent Plasma Donors Increases Binding and Neutralizing Antibodies Against SARS-CoV-2 Variants</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: COVID-19 convalescent plasma (CCP) was widely used as passive immunotherapy during the first waves of SARS-CoV-2 infection in the US. However, based on observational studies and randomized controlled trials, beneficial effects of CCP were limited, and its use was virtually discontinued early in 2021, in concurrence with increased vaccination rates and availability of monoclonal antibody (mAb) therapeutics. However, as new variants of the SARS-CoV-2 spread, interest in CCP derived from vaccine-boosted CCP donors is resurging. The effect of vaccination of previously infected CCP donors on antibodies against rapidly spreading variants of concern (VOC) is still under investigation. Study Design/Methods: In this study, paired samples from 11 CCP donors collected before and after vaccination were tested to measure binding antibodies levels and neutralization activity against the ancestral and SARS-CoV-2 variants (Wuhan-Hu-1, B.1.1.7, B.1.351, P.1, D614G, B.1.617.2, B.1.427) on the Ortho Vitros Spike Total Ig and IgG assays, the MSD V-PLEX SARS-CoV-2 Panel 6 arrays for IgG binding and ACE2 inhibition, and variant-specific Spike Reporter Viral Particle Neutralization (RVPN) assays. Results/Findings: Binding and neutralizing antibodies were significantly boosted by vaccination, with several logs higher neutralization for all the variants tested post-vaccination compared to the pre-vaccination samples, with no difference found among the individual variants. Discussion: Vaccination of previously infected individuals boosts antibodies including neutralizing activity against all SARS-CoV-2 VOC, including the current spreading delta (B.1.617.2) variant. Animal model and human studies to assess clinical efficacy of vaccine boosted CCP are warranted, especially since 15-20% of current donations in the US are from previously infected vaccine-boosted donors.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.28.21265622v1" target="_blank">Vaccination of COVID-19 Convalescent Plasma Donors Increases Binding and Neutralizing Antibodies Against SARS-CoV-2 Variants</a>
</div></li>
<li><strong>Factors associated with acceptance of a digital contact tracing application for COVID-19 in the Japanese working-age population</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objective: This study aimed to determine factors associated with acceptance of a Digital Contact Tracing (DCT) app for Coronavirus Disease 2019 (COVID-19) in the Japanese working-age population. Methods: A cross-sectional study was performed for 27,036 full-time workers registered with an internet survey company during December 2020 in Japan. Results: The rate of downloading the DCT app was 25.1%. The DCT app was more likely to be accepted by people with married status, university graduation or above, higher income, and occupations involving desk work. Fear of COVID-19 transmission, wearing a mask, using hand disinfection, willingness to be vaccinated against COVID-19, and presence of an acquaintance infected with COVID-19 were also associated with a greater likelihood of adopting the app. Conclusions: The present findings have important implications for widespread adoption of DCT apps in working-age populations in Japan and elsewhere.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.28.21265601v1" target="_blank">Factors associated with acceptance of a digital contact tracing application for COVID-19 in the Japanese working-age population</a>
</div></li>
<li><strong>Validation of a Novel IoT and AI based Point-of-Care Testing Laboratory: Analytical Accuracy and Clinical Agreement</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Point-of-care testing (POCT) offers several advantages over traditional laboratory testing. Offering less invasive testing with a faster turnaround time is not enough if not associated with an acceptable level of accuracy. Here, we show the analytical validation behind the multi-analyte POCT immunochromatography analyser, Hilab Flow (HiF). Analyses from 4,518 clinical samples were compared to College of American Pathologists accredited laboratories for ten quantitative and thirteen qualitative exams. Compatibility between methods was evaluated in terms of association/correlation and clinical agreement. Strong correlation/ concordance was observed between quantitative (CHOL, HDL-c, TG, HbA1c, Glycemia, 25-Hydroxy Vitamin D, TSH, Uric Acid, Creatinine, Urea) and qualitative methods (COVID-19 IgG/ IgM, Beta-hCG, Syphilis, Anti-HBsAg, Zika IgG/ IgM, Influenza A/B, HIV, HCV, HBsAg, Dengue NS1, COVID-19 Ag, Dengue IgG/ IgM, PSA). Approval criteria was obtaining a kappa agreement &gt; 0.8 or a Pearson correlation &gt; 0.9 depending on the exam. Overall percentage agreement was greater than 95% for all exams, indicating a good clinical agreement to gold-standard laboratory-based tests. Results indicate all exams are suitable for POCT and present a reliable performance. Data support the analyser is a useful tool to aid decision-making at the clinical setting, with potential to contribute with healthcare solutions in diagnostic medicine worldwide.
</p>
</div>
<div class="article-link article- html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.10.29.21264864v1" target="_blank">Validation of a Novel IoT and AI based Point-of-Care Testing Laboratory: Analytical Accuracy and Clinical Agreement</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Study of Pharmacokinetics, Safety, Tolerability, and Efficacy of Intravenous Anti-Spike(s) SARS-CoV-2 Monoclonal Antibodies (Casirivimab+Imdevimab) for the Treatment of Pediatric Patients Hospitalized Due to COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: casirivimab+imdevimab<br/><b>Sponsor</b>:  <br/>
Regeneron Pharmaceuticals<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety of Heterologous and Homologous Boosting With ChAdOx1-S and CoronaVac or a Formulation of SCB-2019 (COVID-19)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: ChAdOx1-S COVID-19 Vaccine(Fiocruz/Oxford- AstraZeneca);   Biological: CoronaVac (Sinovac Biotech);   Biological: Adjuvanted Recombinant SARS-CoV-2 TrimericS- protein Subunit Vaccine (SCB-2019 - Clover)<br/><b>Sponsors</b>:   D’Or Institute for Research and Education;   Bill and Melinda Gates Foundation;   Instituto Fernandes Figueira<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tocilizumab Versus Baricitinib in Patients With Severe COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Tocilizumab;   Drug: Baricitinib<br/><b>Sponsor</b>:   University Hospital of Patras<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Efficacy and Safety of Pyramax in Mild to Moderate COVID-19 Patients (Phase3)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Pyramax;   Drug: Placebo<br/><b>Sponsor</b>:  <br/>
Shin Poong Pharmaceutical Co. Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>JINZHEN for Treatment of Mild to Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: JINZHEN Granules for Oral Solution;   Drug: Placebo<br/><b>Sponsor</b>:   Lianyungang Kanion Group, Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effectiveness of Using Interactive Consulting System to Enhance Decision Aids of COVID-19 Vaccination</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Device: Chatbot<br/><b>Sponsor</b>:   Sun Yat- sen University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Apixaban in COVID-19 Coagulopathy Patients With Respiratory Severity Under Critical Care</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Apixaban<br/><b>Sponsors</b>:  <br/>
Scotmann Pharmaceuticals;   Rawalpindi Medical College<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Validation of Breath Analyser Tests for Diagnosis of COVID-19.</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Diagnostic Test: Breath Sample analysis<br/><b>Sponsor</b>:   Tera Group<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy, Safety, and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant two-component COVID-19 vaccine (CHO cell);   Biological: Placebo<br/><b>Sponsor</b>:   Jiangsu Rec-Biotechnology Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cardiovascular Assessment in Patient Recovered From COVID-19 and Recovery of Autonomic Nervous System in Association With the Severity of the Disease</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Non invasive cardiovascular monitoring with CNAP device of arterial pressure, ECG and respiratory activity<br/><b>Sponsor</b>:   IRCCS Policlinico S. Donato<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of KOVIR (TD0068) in the Combination Regimen With Background Treatment in COVID-19 Patients (KOVIR)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: KOVIR (TD0068) oral capsule;   Dietary Supplement: Placebo oral capsule<br/><b>Sponsors</b>:   Sunstar Joint Stock Company;   Vietstar Biomedical Research<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV2 Infection<br/><b>Interventions</b>:   Biological: Ad5-triCoV/Mac;   Biological: ChAd-triCoV/Mac<br/><b>Sponsors</b>:   McMaster University;   Canadian Institutes of Health Research (CIHR)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of PBM on Functional Capacity and Fatigability in Post Covid-19 Elderly</strong> - <b>Condition</b>:   Post Covid-19 Elderly<br/><b>Interventions</b>:   Radiation: photobiomodulation;   Other: placebo intervention by photobiomodulation device<br/><b>Sponsor</b>:   Cairo University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) Booster Study</strong> - <b>Condition</b>:   COVID-19 Pandemic<br/><b>Interventions</b>:   Biological: Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01);   Biological: Blank Preparation of Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01)<br/><b>Sponsor</b>:   Livzon Pharmaceutical Group Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Home-based Brain Stimulation Treatment for Post-acute Sequelae of COVID-19 (PASC)</strong> - <b>Condition</b>:   Post-Acute Sequelae of COVID-19<br/><b>Interventions</b>:   Device: Active tDCS;   Device: Sham tDCS<br/><b>Sponsor</b>:   Massachusetts General Hospital<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential of turmeric-derived compounds against RNA-dependent RNA polymerase of SARS-CoV-2: An in-silico approach</strong> - The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. Currently, there are no particular antivirals available to battle with COVID-19. The RNA-dependent RNA polymerase (RdRp) has emerged as a novel drug target due to its essential role in virus replication. In this study, turmeric-derived compounds were chosen and subjected to in-silico analysis to evaluate their binding affinity against the RdRp-RNA complex of SARS-CoV-2. Our in-silico…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dysregulation of RNA interference components in COVID-19 patients</strong> - OBJECTIVE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the novel coronavirus causing severe respiratory illness (COVID-19). This virus was initially identified in Wuhan city, a populated area of the Hubei province in China, and still remains one of the major global health challenges. RNA interference (RNAi) is a mechanism of post-transcriptional gene silencing that plays a crucial role in innate viral defense mechanisms by inhibiting the virus replication as well as…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis</strong> - The incidence and severity of sepsis is higher among individuals of African versus European ancestry. We found that genetic risk variants (RVs) in the trypanolytic factor apolipoprotein L1 (APOL1), present only in individuals of African ancestry, were associated with increased sepsis incidence and severity. Serum APOL1 levels correlated with sepsis and COVID-19 severity, and single-cell sequencing in human kidneys revealed high expression of APOL1 in endothelial cells. Analysis of mice with…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Specific delivering of RNAi using Spike’s aptamer-functionalized lipid nanoparticles for targeting SARS-CoV-2: A strong anti-Covid drug in a clinical case study</strong> - Coronavirus (SARS-CoV-2) as a global pandemic has attracted the attention of many scientific centers to find the right treatment. We expressed and purified the recombinant receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein, and specific RBD aptamers were designed using SELEX method. RNAi targeting nucleocapsid phosphoprotein was synthesized and human lung cells were inoculated with aptamer-functionalized lipid nanoparticles (LNPs) containing RNAi. The results demonstrated that RBD…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Snake venom phospholipase A(2)s exhibit strong virucidal activity against SARS-CoV-2 and inhibit the viral spike glycoprotein interaction with ACE2</strong> - The COVID-19 pandemic caused by SARS-CoV-2 requires new treatments both to alleviate the symptoms and to prevent the spread of this disease. Previous studies demonstrated good antiviral and virucidal activity of phospholipase A(2)s (PLA(2)s) from snake venoms against viruses from different families but there was no data for coronaviruses. Here we show that PLA(2)s from snake venoms protect Vero E6 cells against SARS-CoV-2 cytopathic effects. PLA(2)s showed low cytotoxicity to Vero E6 cells with…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Racial/Ethnic Disparities in State-Level COVID-19 Vaccination Rates and Their Association with Structural Racism</strong> - CONCLUSIONS: There are marked racial disparities in COVID-19 vaccination throughout the USA, and structural racism is strongly associated with the magnitude of these disparities. Efforts to reduce these disparities must address not only individual behavior but must also confront the structural barriers that are inhibiting equitable vaccine distribution.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virtual Screening on Marine Natural Products for Discovering TMPRSS2 Inhibitors</strong> - Although SARS-CoV-2 entry to cells strictly depends on angiotensin-converting enzyme 2 (ACE2), the virus also needs transmembrane serine protease 2 (TMPRSS2) for its spike protein priming. It has been shown that the entrance of SARS- CoV-2 through ACE2 can be blocked by cellular TMPRSS2 blockers. The main aim of this study was to find potential inhibitor(s) of TMPRSS2 through virtual screening against a homology model of TMPRSS2 using the library of marine natural products (MNPs). The homology…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Acting Proactively to Manage Job Insecurity: How Worrying About the Future of One’s Job May Obstruct Future-Focused Thinking and Behavior</strong> - An increasing number of people experience insecurity about the future of their job, making it more important than ever to manage this insecurity. While previous research suggests that proactive coping is a promising way to alleviate job insecurity, we suggest that, paradoxically, it may be particularly difficult to act proactively when feeling emotionally distressed about the future of one’s job. Drawing on the principle of resource scarcity and the Conservation of Resources theory, we propose…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Co-infection of SARS-CoV-2 and influenza virus causes more severe and prolonged pneumonia in hamsters</strong> - Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently a serious public health concern worldwide. Notably, co-infection with other pathogens may worsen the severity of COVID-19 symptoms and increase fatality. Here, we show that co-infection with influenza A virus (IAV) causes more severe body weight loss and more severe and prolonged pneumonia in SARS-CoV-2-infected hamsters. Each virus can efficiently spread in the lungs without…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Characterizing the BCR repertoire during lymphocyte reduction and recovery mediated by cyclophosphamide and granulocyte-macrophage colony-stimulating factor</strong> - Leukopenia is a common manifestation of many diseases, including global outbreak SAS-CoV-2 infection. Granulocyte- macrophage colony-stimulating factor (GM -CSF) has been proved to be effective in promoting lymphocyte regeneration, but adverse immunological effects have also emerged. This study aim to investigate the effect of GM -CSF on BCR heavy chain CDR3 repertoire while promoting lymphocyte regeneration. Cyclophosphamide (CTX) and GM -CSF were used to inhibit and stimulate bone marrow…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19: A review of newly formed viral clades, pathophysiology, therapeutic strategies and current vaccination tasks</strong> - Today, the world population is facing an existential threat by an invisible enemy known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) or COVID-19. It is highly contagious and has infected a larger fraction of human population across the globe on various routes of transmission. The detailed knowledge of the SARS-CoV-2 structure and clinical aspects offers an important insight into the evolution of infection, disease progression and helps in executing the different therapies…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: potential role for Glyoxalase</strong> - An increase in opioid-overdose deaths was evident before the COVID-19 pandemic, and has escalated since its onset. Fentanyl, a highly potent synthetic opioid, is the primary driver of these recent trends. The current study used two inbred mouse strains, C57BL/6J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Heart-rate-variability (HRV), predicts outcomes in COVID-19</strong> - CONCLUSION: Higher HRV predicts greater chances of survival, especially in patients aged 70 years and older with COVID-19, independent of major prognostic factors. Low HRV predicts ICU indication and admission in the first week after hospitalization.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Quercetin and its derivates as antiviral potentials: A comprehensive review</strong> - Quercetin, widely distributed in fruits and vegetables, is a flavonoid known for its antioxidant, antiviral, antimicrobial, and antiinflammatory properties. Several studies highlight the potential use of quercetin as an antiviral, due to its ability to inhibit the initial stages of virus infection, to be able to interact with proteases important for viral replication, and to reduce inflammation caused by infection. Quercetin could also be useful in combination with other drugs to potentially…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia</strong> - In addition to respiratory complications produced by SARS-CoV-2, accumulating evidence suggests that some neurological symptoms are associated with the disease caused by this coronavirus. In this study, we investigated the effects of the SARS-CoV-2 spike protein S1 stimulation on neuroinflammation in BV-2 microglia. Analyses of culture supernatants revealed an increase in the production of TNF-α, IL-6, IL-1β and iNOS/NO. S1 also increased protein levels of phospho-p65 and phospho-IκBα, as well…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti-SARS-CoV-2 antibodies and uses thereof I</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU339290405">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti-SARS-CoV-2 antibodies and uses thereof II</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU339290406">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>휴대용 자화 육각수물 발생기</strong> - 본인의 발명은, 사람의 신체에서 육각수물 생성에는 한계가 있으며, 동맥혈관, 정맥혈관 내부 혈액은 수분이 약 90% 이며, 건강한 성인이면, 육각수 물은 약 62% 이며, COVID-19 환자, 사고의 부상, 17만개의 질병, 질환으로 조직세포가 손상되면 자기 신체수복을 위해서 육각수 물을 평소보다 많이 흡수 하면서 동반 산소부족 상태가 되며, 육각수물 보충 없이 산소 호흡기를 사용하면 심각한 후유증이 발병 할 수 있다.</p></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">육각수물 부족 상태를 해결하기 위해서, 객관적인 과학적으로 네오디뮴(원자번호 = 60) 3.000 가우스의 자기장을 이용하여서 육각수 물을 62% ~ 80% 이상, 상시 유지 시켜주는 제조 방법이며, 휴대용으로 항시 착용 가능하다. 결론은 COVID-19, 질병, 질환의 근본적인 원인은, 육각수물 부족 상태가 되면 동반 산소 부족 상태가 되면서, 염증 -&gt; 통증 -&gt; 극심한 통증 -&gt; 석회화, 섬유화, 암 까지 발병 한다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR338655754">link</a></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>휴대용 자화 육각수물 발생기</strong> - 본인의 발명은, 사람의 신체에서 육각수 생성에는 한계가 있으며, 동맥혈관, 정맥혈관 내부 혈액은 수분이 90% 이며, 육각수물은 약 62% 이며, COVID-19, 사고 부상, 질병, 질환으로 조직세포가 손상되면 자기 신체수복을 위해서 육각수물을 평소보다 많이 흡수하면서 산소부족 상태가 되며, 육각수 보충 없이 산소호흡기를 사용하면 심각한 후유증이 발병 할 수 있다 육각수물 부족 상태를 해결하기 위해서, 객관적인 과학적으로 네오디뮴(원자번호 = 60) 3.000 가우스의 자기장을 이용하여서 육각수물을 62% ~ 80% 상시 유지 시켜주는 제조 방법이며, 휴대용으로 항시 착용 가능하다. 결론은 COVID-19, 질병, 질환의 근본적인 원인은, 육각수물 부족 상태가 되면 동반 산소 부족 상태가 되면서, 염증 -&gt; 통증 -&gt; 극심한 통증 -&gt; 석회화, 섬유화, 암 까지 발병 한다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR338650904">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>用于检测新冠病毒的配对抗体及其应用</strong> - 本发明涉及一种用于检测新冠病毒的配对抗体及其应用，其包括第一检测抗体和第二检测抗体；第一检测抗体具有如SEQ ID NO:1~3所示的轻链互补决定区，以及如SEQ ID NO:4~6所示的重链互补决定区，第二检测抗体具有如SEQ ID NO:7~9所示的轻链互补决定区，以及如SEQ ID NO:10~12所示的重链互补决定区。本发明筛选得到具有上述互补决定区序列的配对抗体，其识别N蛋白的不同表位，且由于两种抗体识别的是N蛋白非核酸结合区域，不会受核酸负电荷干扰，对核酸抗原表现出了兼容性，具有较好的稳定性，同时上述配对抗体具有较高的亲和力，病毒N蛋白检测灵敏度高。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN339127990">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>抗KL-6双特异性抗体及基因、重组载体、药物、试剂盒</strong> - 本发明公开了抗KL‑6双特异性抗体或其变体、或其功能性片段，所述抗KL‑6双特异性抗体或其变体、或其功能性片段包括抗PTS域和抗SEA域，所述抗PTS域的重链可变区的CDR1、CDR2和CDR3分别具有SEQ ID NO.1~3所示的氨基酸序列。本发明还提供了基因、重组载体、药物、试剂盒。本发明的抗KL‑6双特异性抗体或其变体、或其功能性片段用于与KL‑6蛋白特异性结合，基因、重组载体用于抗KL‑6双特异性抗体的制备，药物用于治疗KL‑6蛋白引起的相关疾病，试剂盒用于KL‑6蛋白的定量检测。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN338723529">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>基于决策树模型与逻辑回归模型组合的感染筛查方法</strong> - 本发明公开了一种基于决策树模型与逻辑回归模型组合的感染筛查方法，其检测操作方便，可提高感染筛查准确性，该方法基于生命体征监护仪实现，生命体征监护仪与远程数据服务平台通信连接，远程数据服务平台依据临床数据进行感染筛查，该方法包括：通过生命体征监护仪检测获取用户临床数据，将临床数据随机划分为训练集、测试集，将训练集均分为两份：训练集A、训练集B，基于训练集A构建决策树模型，同时，对训练集A进行特征选择，将关键特征向量作为已构建的决策树模型的输入，获取新构造特征向量，基于组合特征向量，构造逻辑回归模型，基于决策树模型和逻辑回归模型组合，对测试集进行预测分类，获取分类结果。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN339127711">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>病毒中和抗体与非中和抗体联合检测方法、检测卡及应用</strong> - 一种病毒中和抗体与非中和抗体联合检测方法、检测卡及其应用，通过病毒受体结合蛋白夹心法原理检测中和抗体，其为通过提前设置病毒受体结合蛋白和能阻断中和抗体与其结合的作为配体的蛋白所形成的复合物，将靶向受体蛋白的非中和抗体提前捕获，保证后续通过夹心法检测中和抗体的特异性。解决了现有技术中中和抗体检测灵敏度低、特异性差以及不能区分中和抗体与非中和抗体的问题，提供了一种简便、快速、灵敏度高、特异性高的病毒中和抗体与非中和抗体联合检测方法、检测卡及其应用。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN338613501">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>扩增△500-532的SARS-CoV-2 Nsp1基因的引物对及其检测方法</strong> - 本发明公开了一种扩增Δ500‑532的SARS‑CoV‑2 Nsp1基因的引物对及其检测方法。引物对的具体序列如SEQ ID NO.1和SEQ ID NO.2所示，其检测方法为：采用引物对对SARS‑CoV‑2 Nsp1基因进行PCR，对PCR产物进行变性退火后，加入T7EI内切酶孵育，再进行PCR扩增，并判断是否存在Δ500‑532的SARS‑CoV‑2 Nsp1基因。本发明可简便快捷的区分出SARS‑CoV‑2 Nsp1基因突变型和野生型。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN339334235">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>多肽及其在新型冠状病毒检测中的应用</strong> - 本发明涉及生物医学领域，具体而言，涉及一种多肽及其在新型冠状病毒检测中的应用。所述多肽包括如下部分：S——Linker——N——avi‑tag。通过经过优化的刚性linker序列把S蛋白和N蛋白串联起来，使得这两个蛋白即具备相对独立的空间构象，又增加了许多优势表位，很大程度上提高了灵敏度和信号值；此外，融合蛋白引入Avi‑tag，使得重组蛋白可以通过固定的位点被固相化，降低包被过程所带来的空间位阻的影响。由此，该多肽能够达到很高的灵敏度和特异性，并且不易发生漏检。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN339334229">link</a></p></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Virginia Governor’s Race Will Be the Latest Verdict in the Culture Wars</strong> - In the contest between Glenn Youngkin and Terry McAuliffe, the candidates are less important than the grassroots battles that have defined state politics. - <a href="https://www.newyorker.com/news/annals-of-inquiry/the-virginia-governors-race-will-be-the-latest-verdict-in-%20the-culture-wars">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Another Buffalo Is Possible</strong> - This summer, India Walton looked likely to become the first Black woman to lead Buffalo, and the first socialist mayor of any major American city in decades. Then the sitting Democratic mayor launched a campaign to defeat her. - <a href="https://www.newyorker.com/news/the-political-scene/another-buffalo-is-possible">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biden Can’t Quite Close the Deal—with His Own Party</strong> - “Everybody’s on board,” the President said. But they weren’t, at least not yet. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/biden-cant-quite-close-the-deal-with-his-own-%20party">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Would New York City Employees Rather Lose a Paycheck than Get Vaccinated?</strong> - Thousands of municipal workers have protested the mayor’s mandate, but the measure has largely worked. - <a href="https://www.newyorker.com/news/our-local-correspondents/would-new-york-city-employees-rather-lose-a-paycheck-%20than-get-vaccinated">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What Biden Can’t Do on Student Debt—and What He Won’t Do</strong> - Activists argue that the President could cancel student debt with the stroke of a pen, fulfilling a campaign promise. Newly uncovered documents suggest that Biden has been “reviewing” the issue for months. - <a href="https://www.newyorker.com/news/news-desk/what-biden-cant-do-on-student-debt-and-what-he-wont-do">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The criminal complaint against Andrew Cuomo, briefly explained</strong> -
<figure>
<img alt="Andrew Cuomo gestures while speaking at a press briefing in August 2021." src="https://cdn.vox-
cdn.com/thumbor/GMUxJoK4Og5W3bciGVmW8TYbY3k=/292x0:2959x2000/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70068427/1234420097.0.jpg"/>
<figcaption>
Andrew Cuomo, who resigned governor of New York in August, speaks at a press briefing about Covid-19 earlier that month. | Lev Radin/Pacific Press/LightRocket via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The former New York governor was charged with forcible touching, a misdemeanor.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9ztDkw">
More than two months after his <a href="https://voxmedia.stories.usechorus.com/compose/33c0111a-6f95-49b7-b5fe-f75b992c45d9">abrupt fall from power</a>, former New York Gov. Andrew Cuomo is now <a href="https://www.scribd.com/document/535745908/Cuomo-Criminal-
Complaint">facing a criminal complaint</a> alleging he groped a former executive assistant in late 2020.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ftRYKJ">
Cuomo, who resigned from office in August amid a slew of misconduct allegations, was <a href="https://www.nytimes.com/2021/10/28/nyregion/cuomo-forcible-touching-complaint.html?partner=slack&amp;smid=sl-
share">charged on Thursday</a> by the Albany County Sheriff’s Office with forcible touching, a misdemeanor charge that carries a penalty of up to a year in jail.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Bca3vk">
Former Cuomo aide Brittany Commisso has accused Cuomo of groping her while she was working with him at the Executive Mansion in Albany, and she <a href="https://www.wamc.org/wamc-news/2021-08-06/on-wamc-soares-confirms-police-report-has-been-filed-in-cuomo-groping-
case">filed police report</a> in August, shortly after the release of a damning <a href="https://int.nyt.com/data/documenttools/investigation-sexual-harassment-cuomo/6e0c4e9f078d7e2a/full.pdf">report</a> by New York Attorney General Letitia James investigating misconduct claims against Cuomo.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="biOvyy">
The report found that Cuomo <a href="https://www.cnn.com/2021/08/03/politics/cuomo-ag-report-fallout-key-
points/index.html">sexually harassed 11 women</a>, including Commisso — but Commisso’s allegations are the first to result in criminal charges.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HnFaSq">
According to <a href="https://www.nytimes.com/2021/10/28/nyregion/cuomo-
forcible-touching-complaint.html?partner=slack&amp;smid=sl-share">the New York Times</a>, the forcible touching charge brought against Cuomo is often used in circumstances where it’s difficult to prove that the assailant was acting purely for their own sexual gratification. The <a href="https://www.scribd.com/document/535745908/Cuomo-Criminal-
Complaint">charging documents</a> allege that Cuomo groped Commisso “for the purposes of degrading and gratifying his sexual desires.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jg8aIy">
Cuomo is set to appear in Albany City Court on November 17 to be <a href="https://www.cnn.com/2021/10/29/politics/andrew-cuomo-case-albany-county-sheriff-da/index.html">arraigned</a>.
</p></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HxxD1W">
The misdemeanor charge comes after <a href="https://int.nyt.com/data/documenttools/investigation-sexual-
harassment-cuomo/6e0c4e9f078d7e2a/full.pdf">an independent report</a> commissioned by James’s office was released in August, detailing multiple allegations of sexual harassment by Cuomo and a hostile work environment in which dissent was not tolerated and speaking up about alleged abuse could result in retaliation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TJee9v">
Cuomo <a href="https://www.andrewcuomo.com/sites/default/files/files/documents/2021.10.20ResponsetoCommisso_0.pdf">has denied the allegations against him</a> and offered a number of justifications, including that what he considered friendly actions were simply <a href="https://www.nbcnews.com/politics/politics-news/why-cuomo-s-dinosaur-defense-rang-
hollow-n1276514">out of step with the political moment</a>. His attorney, Rita Glavin, <a href="https://apnews.com/article/crime-new-york-andrew-cuomo-albany-d5eaff22837a7189e685965bebb228b6">said in a statement on Friday</a> that Cuomo never assaulted anyone and claimed that the Albany County sheriff, Craig Apple, had acted with political intent.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="086b5W">
<a href="https://www.timesunion.com/state/article/Criminal-summons-
Cuomo-16572344.php?IPID=Times-Union-HP-CP-Latest-News">Confusion</a> over the timing of the complaint gave Glavin some fuel; according to Apple, his office filed the complaint on Thursday morning, not expecting that it would result in a summons being issued the same day.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WQkiUb">
As a result, the complaint became public on Thursday before Apple could notify Albany County District Attorney David Soares, who didn’t know about the complaint until it was leaked to <a href="https://www.nysfocus.com/2021/10/28/charges-filed-against-andrew-cuomo-for-criminal-touching/">New York Focus</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YHQQdQ">
Soares said in a <a href="https://www.nysfocus.com/2021/10/28/charges-filed-against-
andrew-cuomo-for-criminal-touching/">statement</a> that he was “surprised to learn today that a criminal complaint was filed in Albany City Court by the Albany County Sheriff’s Office against Andrew Cuomo.” Soares’s office has been pursuing its own investigation into the sexual harassment allegations against Cuomo.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="astwi7">
According to the <a href="https://www.timesunion.com/state/article/Criminal-summons-Cuomo-16572344.php?IPID=Times-Union-HP-CP-Latest-
News">Albany Times-Union</a>, a summons wasn’t expected until next week, after the sheriff’s office had conferred with Soares and Commisso about moving forward with the case. Commisso’s attorney, Brian Premo, said that she too “was surprised by the turn of events but she has been and will remain a resolute cooperating victim in pursuit of blind justice.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qh6XQ5">
Apple told the <a href="https://www.wsj.com/articles/andrew-cuomos-criminal-summons-
released-faster-than-expected-sheriff-says-11635542298">Wall Street Journal</a> that his office routinely files such paperwork without consulting with prosecutors first, and a spokesperson for the New York state court system, Lucian Chalfen, defended Albany City Court Judge Holly Trexler, saying she “handled the filing of the misdemeanor complaint properly.”
</p>
<h3 id="Nt0QTy">
Cuomo has repeatedly been accused of harassment and misconduct
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8ZvA9D">
In addition to allegations against Cuomo by Commisso and 10 other women, <a href="https://int.nyt.com/data/documenttools/investigation-sexual-harassment-cuomo/6e0c4e9f078d7e2a/full.pdf">the August report</a> painted an alarming picture of pervasive sexual harassment and retaliation by Cuomo and his aides.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7r4gm8">
It detailed accusations ranging from Cuomo asking for help finding a girlfriend and saying that he, in his early 60s, would date a woman as young as 22, to unwanted physical contact, like the kind Commisso described when she <a href="https://www.politico.com/states/new-york/city-hall/story/2021/10/28/misdemeanor-complaint-filed-against-cuomo-
over-forcible-touching-1392121">came forward publicly</a> in August.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zXidNX">
The report was effectively the final straw for an already-embattled Cuomo, who was by August facing <a href="https://www.nytimes.com/2021/04/19/nyregion/andrew-cuomo-book-investigation.html">multiple</a> <a href="https://nymag.com/intelligencer/article/cuomo-investigations-possible-impeachment.html">distinct scandals</a>, including allegations that his administration had <a href="https://www.nytimes.com/2021/03/04/nyregion/cuomo-nursing-
home-deaths.html">deliberately covered up</a> the number of nursing home residents who died of Covid-19 during the pandemic. <a href="https://www.wsj.com/articles/majority-of-new-yorkers-say-gov-andrew-cuomo-shouldnt-run-
again-11625131801">His public support plummeted</a>, and top aide <a href="https://www.cnn.com/2021/08/08/politics/new-
york-governor-cuomo-aide-melissa-derosa-resigns/index.html">Melissa DeRosa</a> resigned after the attorney general’s report showed that she had participated in retaliation against at least one accuser.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FvMMvw">
Sexual harassment allegations against Cuomo began surfacing last year after former aide <a href="https://www.vox.com/22174452/andrew-cuomo-lindsey-boylan-sexual-harassment">Lindsay Boylan</a> accused Cuomo of sexually harassing her “for years” and of retaliating against her by <a href="https://abcnews.go.com/US/cuomo-accuser-
lindsey-boylan-file-lawsuit-embattled-governor/story?id=79288632">releasing confidential personnel</a> files; <a href="https://www.vox.com/2021/3/7/22318003/more-women-accuse-new-york-gov-andrew-cuomo-sexual-harassment">additional accusations</a> earlier this year added momentum to <a href="https://www.vox.com/2021/3/13/22328860/andrew-cuomo-resign-
democrats">calls for Cuomo to resign</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kCO7Kp">
Ultimately, Cuomo, facing an <a href="https://www.nytimes.com/2021/08/09/nyregion/andrew-cuomo.html">accelerating impeachment push</a> backed by state Assembly Speaker Carl Heastie and the chamber’s Democratic majority, announced he was <a href="https://apnews.com/article/andrew-cuomo-resigns-17161f546bb83c32a337036ecf8d2a34">stepping down</a> just one week after the attorney general’s report was released on August 3.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vP9IGf">
Despite Cuomo’s resignation, Heastie said in August that the Assembly would <a href="https://www.nytimes.com/article/cuomo-impeachment.html">continue investigating</a> both the sexual harassment accusations and allegations that the Cuomo administration had deliberately lied about the number of nursing home deaths in the early days of the Covid-19 pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EipRaX">
Thursday’s criminal complaint is just the latest development in Cuomo’s rapid downfall, and it underscores that the allegations that ended his governorship could still become actionable claims, with real legal teeth.
</p>
<h3 id="7gozGY">
Cuomo still claims he’s the victim of a political witch hunt
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3JYuVA">
As with previous sexual misconduct allegations, Cuomo’s attorney, Glavin, has argued that the allegations in Thursday’s criminal complaint are false and politically motivated.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vk0J1v">
“Governor Cuomo has never assaulted anyone, and Sheriff Apple’s motives here are patently improper. Sheriff Apple didn’t even tell the district attorney what he was doing,” <a href="https://twitter.com/ZachReports/status/1453844757835288576?s=20">Glavin said in a statement</a>. “This is not professional law enforcement; this is politics.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8VOYa0">
Specifically, Cuomo’s team has <a href="https://twitter.com/andrewcuomo/status/1454126827572797443?s=20">seized on the initial confusion</a> surrounding the charging announcement, which coincided closely with the announcement of James’s gubernatorial campaign, as evidence of political maneuvering on her part and an “<a href="https://twitter.com/andrewcuomo/status/1454519659680698374?s=20">abuse of power</a>” by Apple in his “rouge [sic] investigation.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fiWL0A">
James <a href="https://apnews.com/article/donald-trump-new-york-andrew-cuomo-kathy-
hochul-15e1fc7cc5ef518503ca561d2fd8034f">announced her gubernatorial campaign</a> on Friday, just one day after the criminal complaint against Cuomo was filed. She will challenge sitting New York Gov. Kathy Hochul, the former lieutenant governor who took over from Cuomo following his resignation, in the Democratic primary, and <a href="https://www.nytimes.com/2021/10/28/nyregion/jumaane-williams-public-advocate-governor.html">other candidates</a> may jump into the Democratic race as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B1QRYO">
James and Cuomo had <a href="https://www.wsj.com/articles/who-is-letitia-james-former-andrew-cuomo-ally-could-help-take-him-
down-11628102625">previously been allies</a>; he endorsed her during her successful 2018 run for attorney general. More recently, however, <a href="https://www.politico.com/states/new-york/albany/story/2021/10/29/she-took-on-cuomo-trump-
and-the-nra-now-tish-james-wants-to-be-governor-1392133">Cuomo and his team</a> have begun to spin James’s probe into the sexual harassment allegations against Cuomo as an abuse of power in pursuit of the governor’s mansion.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8MFWT8">
Cuomo has <a href="https://twitter.com/andrewcuomo/status/1454519659680698374">tweeted repeatedly</a> in the days since the complaint was made public, with statements by Glavin and Cuomo spokesman Rich Azzopardi both claiming there is no evidence to support the criminal charges.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4JhFds">
But <a href="https://www.nytimes.com/2021/08/04/nyregion/andrew-cuomo.html">multiple district attorney’s offices</a> in New York, as well as <a href="https://www.politico.com/states/new-york/albany/story/2021/10/29/albany-sheriff-promises-
overwhelming-amount-of-evidence-against-cuomo-1392135">state Assembly,</a> have been collecting evidence against Cuomo, and Apple has repeatedly said that the mistimed filing of the complaint doesn’t have any bearing on the seriousness of the charges or the strength of the case. Apple <a href="https://thehill.com/homenews/state-watch/579224-sheriff-says-he-
did-not-coordinate-with-da-before-filing-cuomo-complaint">also revealed</a> that he and his team had conducted witness interviews and reviewed copious documents related to the case.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X9GFcw">
“The case is a solid case, our victim is cooperative, and we’re moving forward,” <a href="https://www.politico.com/states/new-
york/albany/story/2021/10/29/albany-sheriff-promises-overwhelming-amount-of-evidence-against-cuomo-1392135">Apple said</a>.
</p>
<ul>
<li><strong>Money Talks: The couple who used lessons from 2008 to navigate 2020</strong> -
<figure>
<img alt="A photo collage of headlines about the recession, including “Student debt at an all-time high”
and “No easy fix for economy.”" src="https://cdn.vox-
cdn.com/thumbor/a1sliuNyzKpycRxbzjKkxB21xVg=/421x0:2965x1908/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70066832/debt.0.jpg"/>
<figcaption>
Getty Images / Christina Animashaun for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Bennie and Krystal Covington have found themselves in a far different place financially than the crash that defined their earlier lives together.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sJ9kah">
<em>Welcome to </em><a href="https://www.vox.com/personal-finance/2019/8/20/20813748/money-debt-personal-finance"><em>Money Talks</em></a><em>, a series in which we interview people about their relationship with money, their relationship with each other, and how those relationships inform one another.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6gR9mP">
<a href="https://www.benniecovington.com/">Bennie Covington</a> and <a href="https://www.krystalcovington.com/">Krystal Covington</a> live in Denver, Colorado with their toddler son. Bennie is 38 years old and works as an HR leader; Krystal is 36 and runs her own public relations business.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nrEDhi">
Between their two jobs and their recently purchased rental property, Bennie and Krystal have a combined annual income in the low six figures — and their savvy financial decisions during the past 18 months not only allowed them to earn back the money they lost during the beginning of the pandemic, but also helped them prepare for whatever the future might bring.
</p>
<hr class="p-entry-hr" id="KuxFna"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b5M9nI">
<strong>Krystal: </strong>At the beginning of 2020, my son was just about to turn 1 year old. I was getting my energy back, my business was going really well, I was really excited for the possibilities — and 60 percent of my income at the time was running live events. My last event was on March 11, 2020. The day after that, they started shutting everything down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DzQrrV">
<strong>Bennie:</strong> I’m a C-level executive, and we were in the midst of our best quarter as a company. Record quarter. We went from there to having sub-record quarters for the next 18 months. It was an amazing roller coaster.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="emBNka">
<strong>Krystal:</strong> I had to shut down, basically.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q6XZDt">
<strong>Bennie:</strong> She had an events-based business, so that changed the whole dynamic. My business involves a lot of traveling to a lot of court systems and municipalities. So we understood that we were about to hit a revenue wall with our organization.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XOnq4W">
Krystal and I were walking around the neighborhood, enjoying our newfound free time, and I said, “It would be interesting to know where we are at the end of this. Are we better off, or are we worse off?” We remembered 2008 very well, and some people came out in a better position — but a lot of people came out in a not-better position.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1aSjZa">
In 2008, we were just starting out. We had nothing but hopes, dreams, and student loan debt. We’re much more established now, so we were able to not only absorb some of the hits but also be opportunistic. During the pandemic, we bought our first rental property. A dip in the market, for us, represented an opportunity to buy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ASMbXu">
<strong>Krystal:</strong> We decided to be more strategic [than in 2008]. We wanted to create some hedging for ourselves, to hedge against what could happen in the future, and also take advantage of the fact that we were seeing a lot of people flocking to new homes. That’s why we decided a rental home would be a good investment.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i7fCth">
Now we have the second income from the rental, and the property has gained in perceived value — I know that stuff isn’t real, it’s just on paper, but it’s still value.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6JZzDZ">
<strong>Bennie:</strong> We did the same thing with stocks. In 2008, when we saw the market dip, I remembered thinking that buying would be the smart move — unless the world was about to end, in which case we’d have bigger problems. This time around, we went in and we kind of went shopping for companies we thought would remain healthy during the pandemic. We took savings and purchased equities and also bought the rental property.
</p>
<div class="c-float-right">
<aside id="5PiemM">
<q>“I remembered thinking that buying would be the smart move — unless the world was about to end, in which case we’d have bigger problems”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L75iry">
<strong>Krystal:</strong> We have a mortgage on the rental property. The savings went to stocks and the down payment.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wKnz09">
<strong>Bennie:</strong> I also still had my job — I took a 20 percent pay cut, but it was still good income. The pay cut ended up translating into about $25,000. The rental property yields about $440 a month, so it pays for the mortgage and helps to cover the salary gap. Whatever we lost, we gained in equity and income.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hduoSL">
<strong>Krystal:</strong> With my business, I got an <a href="https://www.vox.com/2020/4/3/21196191/cares-
act-apply-small-business-loans-grants-ppp-eidl">SBA loan</a> that helped me buy some time to figure things out. I found a different business model strategy to try — I went from event planning to marketing services — and figured out different ways to utilize other people’s labor. So far it’s been working okay, but I’m going to continue tweaking and evolving!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hWhfhK">
All of this has been an ongoing, unique learning cycle — but I was also able to replace my income, and I actually make more now.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1FSw1a">
<strong>Bennie:</strong> It’s incredible when you think about it. When you go back to 2008, we weren’t in the position to take advantage of anything. Now we can, and it’s mindboggling — the world is completely different, depending on where you are.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uZNyv1">
<strong>Krystal:</strong> In 2008, we were in debt.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3oUo0y">
<strong>Bennie:</strong> In 2008, we were at the mercy of the market. Whatever it wanted to give to us, we didn’t really have a lot of negotiating power. A lot of dreams deferred — and that maybe actually led us to getting to this point, because we never really lost that. I don’t like the concept of “work harder,” but we certainly thought “we need to do better.” We need a plan to absorb these shocks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9VgyuF">
But the juxtaposition of these two realities — the way things changed for us in 12, 13 years — it’s been very interesting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E2wfgd">
<strong>Krystal:</strong> In 2008, I don’t think we understood the concept of ownership. Between that, and the period when my husband lost his job and our savings<em> </em>saved us —
</p></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="59zwT9">
<strong>Bennie:</strong> We weren’t investing in the market then, it was just in savings accounts —
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x9Eyxo">
<strong>Krystal:</strong> We started living on very little and saving one income. That’s what allowed us to move to Colorado and buy our first condo. We saw the market was about to get to the point where people couldn’t even buy a house, so —
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="17w9dn">
<strong>Bennie:</strong> We sold it and bought another house!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DFs3ig">
<strong>Krystal:</strong> We realized ownership was extremely valuable, especially in a market that was growing. Then, in this situation, we realized the people who were doing really well were the people who had ownership. It made sense that people who own property, people who have income sources that aren’t tied to employers, are doing okay.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J5S2xm">
<strong>Bennie:</strong> We’re in this position right now because of the time between 2008 and 2020. We recognized that we weren’t in the position to absorb dips, so we decided to become proactive. When the pandemic came out of nowhere — and these things always do — we were in a position to look for opportunities. But we wouldn’t have been if we hadn’t spent the period between 2008 and 2020 getting ready.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Hi8JUW">
<strong>Krystal:</strong> We also used that time to educate ourselves. We watch all of the things about <a href="https://www.vox.com/the-highlight/2020/3/18/21182018/financial-independence-retire-early-fire-early-retirement-mr-
money-mustache-pete-adeney">FIRE</a>, we read all of the stories, we share with each other, “Oh, these people make about as much as we make and this is what they do with their money, that’s interesting,” and we talk through it. We read books together, we try to listen to the same books on Audible, because hearing the information and talking through it — “What do you see in this philosophy?” — helps us understand that there are different pathways.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tYOP9y">
We also both worked in the financial industry for a few years. I was in communications and he was in training/development. Being adjacent to all of that helped us too — being around all of these people who had a lot of money and were talking about it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="p5f0U2">
<strong>Bennie:</strong> In 2008 there was a narrative and there was data. We followed the data. How did people end up financially stronger at the end of the recession? We weren’t looking at the 1 percent, we were looking at the upper-middle class. Nobody was talking about them, but I was intrigued — what happened there? What allowed them to do that? That was what was in my head when 2020 happened.
</p>
<ul>
<li><strong>Why progressives still aren’t voting for the infrastructure bill</strong> -
<figure>
<img alt="Representative Pramila Jayapal stands outside speaking to reporters." src="https://cdn.vox-
cdn.com/thumbor/BnZ2YEaGTMaw11u3EERxqKoU02c=/0x0:5333x4000/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70066696/1236033004.0.jpg"/>
<figcaption>
Rep. Pramila Jayapal, the head of the Congressional Progressive Caucus, said members would vote down an infrastructure bill if it came to the floor on Thursday. | Sarah Silbiger/Bloomberg via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It’s the only leverage they have to guarantee that the social spending bill moves forward.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="a9GN0h">
Moderate Sens. Joe Manchin (D-WV) and Kyrsten Sinema (D-AZ) have demanded major cuts to Democrats’ Build Back Better bill, a large climate and social spending package that’s been in the works for months. Progressives fear further cuts — and some worry the bill might be abandoned altogether — if Manchin and Sinema can’t be compelled to accept the $1.75 trillion spending proposal currently on offer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KazKqO">
Their strategy to pin the senators down was on display Thursday, when the Congressional Progressive Caucus refused to move forward on a bipartisan infrastructure bill without a simultaneous vote on Democrats’ larger social spending bill. Because House Democrats have a narrow three-person margin, any major defections can sink legislation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QdkgCv">
Progressive members have for weeks demanded that the votes on the two bills be held together. They worry that Manchin and Sinema — who back the infrastructure package — could completely abandon the budget bill should infrastructure advance on its own, given their longstanding opposition to the size of the measure and to several of the policies it contains.
</p>
<div id="JXdAa2">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
The best way to guarantee that Kyrsten Sinema and Joe Manchin support the President’s framework is for the Build Back Better Act to pass in the Senate first.<br/><br/>The people — not just some, but ALL of our people — must win.
</p>
— Cori Bush (<span class="citation" data-cites="CoriBush">@CoriBush</span>) <a href="https://twitter.com/CoriBush/status/1453893447669145623?ref_src=twsrc%5Etfw">October 29, 2021</a>
</blockquote></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gnZ5BV">
To ensure the two senators support the spending package, progressives are using the bipartisan bill as leverage: In order to pass one, Democrats need to get on board with passing the other as well. Tying the two votes together is also a way to prevent moderate lawmakers from whittling down the spending bill even further. The sooner moderates agree to the latest spending proposal numbers, the sooner they’ll get their vote on infrastructure.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W0n6bp">
“Congress needs to finish the job and bring both bills to a vote together,” the Congressional Progressive Caucus wrote in a statement explaining their stance. “There is too much at stake for working families and our communities to settle for something that can be later misunderstood, amended, or abandoned altogether.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VNAGrw">
Progressive pressure on Thursday secured an infrastructure vote delay, which marked a win for them. It also followed a loss: The latest version of the spending bill, which progressives have announced they’d accept, includes some serious cuts. The plan, released by the White House Thursday, doesn’t include many of their key priorities, including paid family leave and Medicare’s ability to negotiate prescription drug prices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JHN3NX">
Despite this, they appear to have now decided to take what they can. They want Manchin and Sinema to do the same and hope to use what leverage they have into making sure they do so.
</p>
<h3 id="76mSeL">
What progressives hope to gain in the next week
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="75OgqY">
Progressives called for the infrastructure vote delay for two reasons: They wanted specifics about the text of the social spending legislation, and they wanted direct assurances from Manchin and Sinema that they’d vote to pass the social spending bill.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uQPCbF">
A core issue at play is a lack of trust: Because of how many cuts Manchin and Sinema have already demanded to key Democratic priorities (including reducing prescription drug prices, increases to the corporate tax rate, and eliminating the Clean Energy Performance Program), progressives are wary of their support for the Biden framework. Additionally, neither senator has publicly said they support the framework. That has progressives concerned since Democrats have approved a budget resolution framework before only to have the legislation itself stall.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="knCT4n">
“I don’t owe them my trust, and they don’t owe me theirs,” <a href="https://twitter.com/MSNBC/status/1454070795563683844">Rep. Cori Bush (D-MO) said in an MSNBC interview</a>. “Let us see the vote. … That’s how we know where you stand.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wTs9rJ">
Progressives’ concerns weren’t assuaged after the release of President Joe Biden’s $1.75 trillion framework for the legislation. While the CPC publicly endorsed the measure in principle, both Manchin and Sinema issued positive statements about negotiations without any concrete commitments.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="APo1iS">
“As we work through the text of the legislation, I would hope all of us will continue to deal in good faith and do what is right for the future of the American people,” <a href="https://twitter.com/Sen_JoeManchin/status/1453858737039581184">Manchin said in a statement</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2VtIft">
“I look forward to getting this done, expanding economic opportunities and helping everyday families get ahead,” <a href="https://twitter.com/SenatorSinema/status/1453749851246714885">Sinema said in a separate statement. </a>
</p>
<div id="obYgv9">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
I’ve lost count of how many interactions with reporters that Sen. Manchin has had today. His unwillingness to just come out and say he supports a WH framework - that was negotiated more directly with him than probably any other lawmaker - seems notable.
</p>
— Garrett Haake (<span class="citation" data-cites="GarrettHaake">@GarrettHaake</span>) <a href="https://twitter.com/GarrettHaake/status/1453820158598856713?ref_src=twsrc%5Etfw">October 28, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jNbdRR">
Progressives want a guarantee that all Democratic senators are actually on board with this bill, and that Manchin or Sinema won’t blow up the framework. They’ve already seen this process play out once: Democrats in both the House and the Senate passed a $3.5 trillion budget resolution, but both moderates balked at moving forward with that price tag and many of its components.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DTCoVZ">
“We need to have certainty, either through legislative text, through … agreements … that we can trust,” Rep. Alexandria Ocasio-Cortez (D-NY) told reporters Thursday.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S8G0Qa">
The caucus’s demand for legislative text has led to results. In an effort to convince progressives to consider a vote on the bipartisan infrastructure bill, the House Rules Committee released <a href="https://www.eenews.net/articles/democrats-release-text-of-budget-reconciliation-package/">1,700 pages</a> of tentative text on Thursday. That text didn’t wind up being enough for a vote because, as with the framework, Manchin and Sinema have yet to agree to it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PaZZpz">
Jayapal noted Thursday that progressives would support adding policies back into the legislation that were stripped out of Biden’s framework, like paid family leave and Medicare expansion provisions. She said, however, that progressive support for the framework was not contingent on these additions and that they stood behind the endorsement they’ve made.
</p>
<h3 id="9JeAjf">
Progressives won and lost this week
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ku5ekv">
Thursday marked the second time progressives successfully blocked a vote on infrastructure over concerns about the spending bill. This time, they faced increased pressure from congressional leaders to reverse their position, in order to send Biden off to his coming G20 climate meetings with a legislative win to tout.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jxhzRL">
But the caucus held firm.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MGodnt">
Originally, progressives had identified five broad areas where they wanted investments: the care economy, affordable housing, climate jobs, a pathway to citizenship for DACA recipients, and reductions to prescription drug prices. The original $3.5 trillion version of the spending bill included many of these issues, but because of Manchin’s and Sinema’s concerns, multiple areas were significantly cut back or dropped entirely.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EC6oTr">
Biden’s new $1.75 trillion framework ultimately invests heavily in early childhood education and climate but does not include a major provision to help reduce prescription drug prices, a pathway to citizenship for DACA recipients, or paid family leave.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fzHKAo">
And areas that survived cuts still saw dramatic reductions in spending. For example, Democrats’ original budget measure contained $450 billion for long-term home care and $332 billion for affordable housing. Biden’s framework, meanwhile, includes $150 billion for the former and $150 billion for the latter.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CX1tty">
Sinema has opposed enabling Medicare to negotiate prescription drug prices, likely killing it. A pathway to citizenship for DACA recipients also isn’t expected to make it into the legislation because of the rules governing the budget reconciliation process and the Senate parliamentarian’s existing ruling advising against its inclusion. And paid family leave has run into opposition from Manchin, who’s worried that the policy would be too burdensome for businesses.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RDqgkM">
Biden’s framework still has about $100 billion allocated for immigration reform, though it’s unclear whether it will make it past this procedural hurdle. Democrats’ latest pitch to the parliamentarian will focus on issues like the legal visa backlog and a shield from deportation for some unauthorized immigrants, the <a href="https://www.nytimes.com/2021/10/28/us/politics/biden-immigration.html">New York Times reports</a>. Lawmakers are also still finagling some of the details for the bill, leaving the door open for the possible return of some policies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pKPn4p">
Progressives back the framework even with the existing omissions. In its current state, it includes several of their demands on child care subsidies, funding for clean energy tax credits, and a Civilian Climate Corps. Additionally, they argue that the talks on the bill wouldn’t have even happened without the pressure they’ve put on Democratic leadership and moderate lawmakers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OLfKPr">
“The reality is that while talks around the infrastructure bill lasted months in the Senate, there has only been serious discussion around the specifics of the larger Build Back Better Act in recent weeks, thanks to the Progressive Caucus holding the line and putting both parts of the agenda back on the table,” the CPC said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fRmWlo">
Although they are standing their ground on legislation timing, they appear willing to accept the policy concessions that have already been made. “We wanted a $3.5 trillion package, but we understand the reality of the situation,” said Jayapal.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>T20 World Cup | Afghanistan post 160-5 against Namibia</strong> - Playing the last match of his international career, former skipper Asghar Afghan made a 23-ball 31</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>T20 World Cup | England eye semifinal spot, Sri Lanka look for survival</strong> - Pre-tournament favourites England have played as per the expectations in their first three games, steamrolling their opponents, including arch-rivals Australia on the night of October 30</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>10 sportspersons from PSUs recommended for National Sports awards</strong> - Hockey coach Sandeep Sangwan has been recommended for Dronacharya Award</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>T20 World Cup | Guptill fit for India game</strong> - Guptill was hit on his left foot during his side’s defeat against Pakistan</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sumit, Nishant in AIBA men’s World boxing championships pre-quarterfinals</strong> - Gonzales too good for Sachin</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kerala State Electricity Board can meet power requirements for SilverLine project, says KSEB chairman</strong> - After the KSEB disclosed power requirement estimations for the ₹63,941-crore project following talks with the K-Rail, B. Ashok said the Kerala State power utility deems the project a business opportunity</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>11 killed, four injured in road accident in Uttarakhand’s Chakrata</strong> - The accident took place on the Bulhad-Baila road in Chakrata</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haryana bans firecrackers in 14 National Capital Region districts</strong> - The directive will also apply to all cities and towns in the State where the average of ambient air quality during November (as per available data of last year) is in “poor” and above categories</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>30 fall ill after consuming spurious toddy, recovered</strong> - Excise officials seize chemical substance used for adulterating toddy</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Maharashtra Minister’s allegations against NCB official Wankhede baseless: Athawale</strong> - Sameer Wankhede is an Ambedkarite, his father’s name is not Dawood: RPI (A) chief</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Up to France to end fishing row, says UK government</strong> - Boris Johnson tells Emmanuel Macron to “de-escalate the rhetoric” around the post-Brexit issues.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Greta Thunberg: It’s never too late to do as much as we can</strong> - Activist Greta Thunberg is still hopeful the world can achieve “massive changes” to combat climate change.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>G20: World leaders agree to historic corporate tax deal</strong> - Leaders at the G20 in Rome endorse a proposal that sets a minimum tax rate of 15% on big businesses.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Man dies during bull-running event in Spanish city of Onda</strong> - Authorities said the man suffered a head wound and had an artery punctured in his thigh by the bull.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>La Palma volcano survivors shaken but determined to rebuild</strong> - A vast lava flow reshapes a Canary Islands landscape, but does not crush the locals’ hopes.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>This is the world’s oldest image of a ghost</strong> - The Babylonian tablet may have come from an ancient exorcist’s library. - <a href="https://arstechnica.com/?p=1809040">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lidar reveals hundreds of long-lost Maya and Olmec ceremonial centers</strong> - The sites suggest cultural links between the two Mesoamerican civilizations. - <a href="https://arstechnica.com/?p=1808992">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Spiders are much smarter than you think</strong> - Researchers are discovering surprising capabilities among a group of itsy-bitsy arachnids. - <a href="https://arstechnica.com/?p=1808930">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fossil fuels doomed in New York as regulator blocks new gas power plants</strong> - New fossil fuel power plants are “inconsistent” with state climate law. - <a href="https://arstechnica.com/?p=1808996">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Microsoft reclaims title of most valuable public company after Apple falls</strong> - iPhone maker cedes top spot to its tech rival after weak earnings. - <a href="https://arstechnica.com/?p=1809064">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
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<li><strong>What do you get when you mix holy water with laxatives?</strong> - <!-- SC_OFF -->
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A religious movement.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Mr_Charms_505"> /u/Mr_Charms_505 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/qjf904/what_do_you_get_when_you_mix_holy_water_with/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/qjf904/what_do_you_get_when_you_mix_holy_water_with/">[comments]</a></span></p></li>
<li><strong>A teenage girl comes home from school and asks her mother, “Is it true what my friend just told me?”</strong> - <!-- SC_OFF -->
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“What’s that?” asks her mother. “That babies come out of the same place where boys put their penises?” said her daughter. “Yes it is dear” replies her mother, pleased that the subject had finally come up and that she wouldn’t have to explain it to her daughter. “But then, when I have a baby,” responded the teenager, “won’t it knock my teeth out?”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/thenez68"> /u/thenez68 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/qjfbmr/a_teenage_girl_comes_home_from_school_and_asks/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/qjfbmr/a_teenage_girl_comes_home_from_school_and_asks/">[comments]</a></span></p></li>
<li><strong>An infinite number of mathematicians enter a bar</strong> - <!-- SC_OFF -->
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The first orders a pint of beer. The second half a pint, the third a quarter ad infinitum. The bartender just pours two pints and says “figure it out yourselves.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Bootlebat"> /u/Bootlebat </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/qjgwpk/an_infinite_number_of_mathematicians_enter_a_bar/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/qjgwpk/an_infinite_number_of_mathematicians_enter_a_bar/">[comments]</a></span></p></li>
<li><strong>A girl introduces her new boyfriend to her parents.</strong> - <!-- SC_OFF -->
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This is a German joke, but I think I found a way to translate it:
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A girl wants to introduce her new boyfriend to her parents. He knocks on the door and the parents together open the door and introduce themselves: “Hi, my name is Sarah and this is my husband Michael, nice to meet you!”. The girls boyfriend shakes their hands and says: “Nice to meet you too. My name is Tobias and I am here to fuck your daughter.”. The father stares at him shocked and says angrily: “Excuse me?? To what?!” “It’s Tobias, but you can call me Tobi if you like”, he responds and walks in.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/fckcgs"> /u/fckcgs </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/qj1e15/a_girl_introduces_her_new_boyfriend_to_her_parents/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/qj1e15/a_girl_introduces_her_new_boyfriend_to_her_parents/">[comments]</a></span></p></li>
<li><strong>Best Costume (nsfw)</strong> - <!-- SC_OFF -->
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A woman at a costume party sees a man wearing a glass jar over his pecker.
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She asks him what he is dressed as.
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He says, “a firefighter. Break the glass, pull the knob, and I’ll come as fast as I can.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Flapjack_Ace"> /u/Flapjack_Ace </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/qja6la/best_costume_nsfw/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/qja6la/best_costume_nsfw/">[comments]</a></span></p></li>
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