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<title>13 June, 2023</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Assessment of the relationship between Google Trend search data on clinical symptoms and cases reported during the first wave of the COVID-19 outbreak in India.</strong> -
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Infodemiology and infoveillance approaches have been extensively used in recent years to support traditional epidemiology and disease surveillance. Hence, the present study aimed to explore the association between Google Trends (GTs) search of clinical symptoms and cases reported during the first wave of COVID-19. The GT data from January 30, 2020, to September 30, 2020, and daily COVID-19 cases in India and a few selected states were collected from the Ministry of Health and Family Welfare, Government of India. Correlation analysis was performed between the GT index values and the number of confirmed cases. Followed by, the COVID-19 cases were predicted using Bayesian regression and classical linear regression models. A strong association was observed between the search index of clinical symptoms and reported COVID-19 cases (cold: R=0.41, headache: R=0.46, fever: R=0.66, loss of taste: R=0.78, loss of smell R=0.86) across India. Similarly, lagged correlations were also observed (loss of smell, loss of taste, loss of taste and loss of smell, fever and headache show 3, 9, 1, 9, and 13 days lag periods respectively). Besides this, the Bayesian regression model was outperformed (MAE: 0.331164, RMSE: 0.411087) for predicting the COVID-19 cases in India and regionally than the frequentist linear regression (MAE: 0.33134, RMSE: 0.411316). The study helps health authorities better prepare and planning of health care facility timely to avoid adverse impacts.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.08.23291183v1" target="_blank">Assessment of the relationship between Google Trend search data on clinical symptoms and cases reported during the first wave of the COVID-19 outbreak in India.</a>
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<li><strong>Neurodivergence as a risk factor for Post-Covid-19 Syndrome</strong> -
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Neurodivergent (ND) individuals (e.g., Autistic people) are more likely to experience health problems that are characterised by central sensitisation9. Recent research suggests that a so-called Long-COVID syndrome might also be explained by a heightened response to internal physiological stimuli, much like in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Using a standardised assessment tool, we examined whether traits associated with Autism would predict long-term COVID-19 symptoms in 267 Healthcare Workers (HCW).. Higher autistic traits predicted COVID-19 symptoms that lasting more than 12 weeks regardless of formal autism diagnosis. A personality measure also showed that negative affect was associated with experiencing COVID-19 symptoms for 4-12 weeks, though the direction of causality in this case is uncertain. Limitations of the present study are 1) the retrospective nature of COVID-19 symptom reporting; 2) likely self-selection bias given the high number of HCWs who reported long-term COVID-19 symptoms; and 3) the gender-bias towards females in our sample.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.08.23291154v1" target="_blank">Neurodivergence as a risk factor for Post-Covid-19 Syndrome</a>
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<li><strong>Comparison of incidence and prognosis of myocardial injury in patients with COVID-19-related respiratory failure and other pulmonary infections: a contemporary cohort study</strong> -
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Background: Myocardial injury (MI) is frequent in critically ill patients with COVID-19, but its pathogenesis remains unclear. We hypothesized that MI is not solely due to viral infection by SARS-CoV-2, but rather due to the common pathophysiological mechanisms associated with severe pulmonary infections and respiratory failure. Methods: Contemporary and comparative cohort study designed to compare the incidence of MI in patients with acute respiratory failure caused by COVID-19 to that of patients with other pulmonary infections. In addition, we aim to investigate whether MI is a distinct risk factor for in-hospital mortality in patients with COVID-19-related respiratory failure compared to those with non-COVID-19 infections. Results: The study included 1444 patients with COVID-19 [55.5% men; age 58 (46;68) years] and 182 patients with other pulmonary infections [46.9% men; age 62 (44;73) years]. The incidence of MI at ICU admission was lower in COVID-19 patients (36.4%) compared to non-COVID-19 patients (56%), and this difference persisted after adjusting for age, sex, coronary artery disease, heart failure, SOFA score, lactate, and C-reactive protein [RR 0.84 (95% CI, 0.71-0.99)]. MI at ICU admission was associated with a 59% increase in mortality [RR 1.59 (1.36-1.86); P&lt;0.001], and there was no significant difference in the mortality between patients with COVID-19 and those with other pulmonary infections (P=0.271). Conclusion: Myocardial injury is less frequent in patients with critical COVID-19 pneumonia and respiratory failure compared to those with other types of pneumonia. The occurrence of MI is a significant risk factor for in-hospital mortality, regardless of the etiology of the pulmonary infection.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.09.23291222v1" target="_blank">Comparison of incidence and prognosis of myocardial injury in patients with COVID-19-related respiratory failure and other pulmonary infections: a contemporary cohort study</a>
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<li><strong>Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease</strong> -
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One in ten SARS-CoV-2 infections result in prolonged symptoms termed “long COVID”, yet disease phenotypes and mechanisms are poorly understood. We studied the blood proteome of 719 adults, grouped by long COVID symptoms. Elevated markers of monocytic inflammation and complement activation were associated with increased likelihood of all symptoms. Elevated IL1R2, MATN2 and COLEC12 associated with cardiorespiratory symptoms, fatigue, and anxiety/depression, while elevated MATN2 and DPP10 associated with gastrointestinal (GI) symptoms, and elevated C1QA was associated with cognitive impairment (the proteome of those with cognitive impairment and GI symptoms being most distinct). Markers of neuroinflammation distinguished cognitive impairment whilst elevated SCG3, indicative of brain-gut axis disturbance, distinguished those with GI symptoms. Women had a higher incidence of long COVID and higher inflammatory markers. Symptoms did not associate with respiratory inflammation or persistent virus in sputum. Thus, persistent inflammation is evident in long COVID, distinct profiles being associated with specific symptoms.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.07.23291077v1" target="_blank">Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease</a>
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<li><strong>Start Smart, Then Focus: Antimicrobial Stewardship Practice at One NHS Foundation Trust in England Before and During the COVID-19 Pandemic</strong> -
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Background Antimicrobial Resistance (AMR), a major global public health threat causing 1.2 million deaths, calls for immediate action. Antimicrobial stewardship (AMS) promotes judicious antibiotic use, but the COVID-19 pandemic increased AMR by 15%. Our study evaluated AMS implementation and inappropriate antibiotic prescribing before-the-pandemic (PD) and during-the-pandemic (DP). Methods This retrospective study examined medical records of adult patients (age 25 and above) admitted to an NHS Foundation Trust in England for respiratory tract infections (RTIs) or pneumonia in 2019 and 2020. Our objective was to evaluate antibiotic prescribing practices BP and DP in 2019 and 2020. Primary outcomes included evaluating the prevalence of inappropriate antibiotic prescribing and assessing the implementation of AMS using Public Health England9s 9Start Smart, Then Focus9 (SSTF) toolkit. Reliable data extraction was ensured by two independent reviewers using a validated data extraction tool. Results A total of 640 patient records (320 from 2019 and 320 from 2020) were analysed. The mean age of enrolled adults was 74.3 years in 2019 and 76.2 years in 2020. COVID pneumonia showed a significantly higher odds ratio (OR) of 20.24 (95% CI 5.82 to 128.19, p-value&lt;0.001). Inappropriate antibiotic prescribing, as per local guidelines, increased from 36% in 2019 to 64% in 2020 for the second course of antibiotics DP. Differences were observed in AMS interventions, with an OR of 3.36 (95% CI 1.30-9.25, p=0.015) for 9Continue Antibiotics9 and an OR of 2.77 (95% CI 1.37-5.70, p=0.005) for 9De-escalation9. Conclusion The COVID-19 pandemic significantly impacted antibiotic prescribing, increasing inappropriate use and posing risks of antimicrobial resistance. Factors influencing prescribing practices must be considered, and proactive measures, including updating the SSTF toolkit and developing an AMS roadmap, are needed to address the challenges of AMR in the context of evolving infectious diseases.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.09.23291146v1" target="_blank">Start Smart, Then Focus: Antimicrobial Stewardship Practice at One NHS Foundation Trust in England Before and During the COVID-19 Pandemic</a>
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<li><strong>SARS-CoV-2 Nonstructural Proteins 3 and 4 tune the Unfolded Protein Response</strong> -
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Coronaviruses (CoV), including SARS-CoV-2, modulate host proteostasis through activation of stress-responsive signaling pathways such as the Unfolded Protein Response (UPR), which remedies misfolded protein accumulation by attenuating translation and increasing protein folding capacity. While CoV nonstructural proteins (nsps) are essential for infection, little is known about the role of nsps in modulating the UPR. We characterized the impact of SARS-CoV-2 nsp4, a key driver of replication, on the UPR using quantitative proteomics to sensitively detect pathway-wide upregulation of effector proteins. We find nsp4 preferentially activates the ATF6 and PERK branches of the UPR. Previously, we found an N-terminal truncation of nsp3 (nsp3.1) can suppress pharmacological ATF6 activation. To determine how nsp3.1 and nsp4 tune the UPR, their co-expression demonstrated that nsp3.1 suppresses nsp4-mediated PERK, but not ATF6 activation. Re-analysis of SARS-CoV-2 infection proteomics data revealed time-dependent activation of PERK targets early in infection, which subsequently fades. This temporal regulation suggests a role for nsp3 and nsp4 in tuning the PERK pathway to attenuate host translation beneficial for viral replication while avoiding later apoptotic signaling caused by chronic activation. This work furthers our understanding of CoV-host proteostasis interactions and highlights the power of proteomic methods for systems-level analysis of the UPR.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.04.22.537917v2" target="_blank">SARS-CoV-2 Nonstructural Proteins 3 and 4 tune the Unfolded Protein Response</a>
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<li><strong>Low Dose Naltrexone use for the management of post acute sequelae of COVID 19</strong> -
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Post-Acute Sequelae of SARS-CoV-2 (PASC), also known as Long COVID, is globally estimated to have affected up to 40-50% of individuals who were infected with SARS-CoV-2. The causes of PASC are being investigated, and there are no established therapies. One of the leading hypotheses for the cause of PASC is the persistent activation of innate immune cells with increased systemic inflammation. Naltrexone is a medication with anti-inflammatory and immunomodulatory properties that has been used in other conditions that overlap with PASC. In this study we performed retrospective review of a clinical cohort of 59 patients at a single academic center who received low-dose naltrexone (LDN) off-label as a potential therapeutic intervention for PASC. The use of LDN was associated with improved clinical symptoms (fatigue, brain fog, post exertional malaise/PEM, unrefreshing sleep, sleep pattern, and headache), fewer number of symptoms, and better functional status. This observational finding warrants further testing in rigorous, randomized, placebo-controlled clinical trials.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.08.23291102v1" target="_blank">Low Dose Naltrexone use for the management of post acute sequelae of COVID 19</a>
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<li><strong>Global seasonal activities of respiratory syncytial virus before the COVID-19 pandemic: a systematic review</strong> -
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Background: Varied seasonal patterns of respiratory syncytial virus (RSV) have been reported worldwide. We aimed to review the patterns of RSV activity globally before the COVID-19 pandemic and to explore factors potentially associated with RSV seasonality. Methods: We conducted a systematic review on articles identified in PubMed reporting RSV seasonality based on data collected before 1 January 2020. Information on the timing of the start, peak, and end of an RSV season, study location, study period, and details in study methods were extracted. RSV seasonal patterns were examined by geographic location, calendar month, analytic method and meteorological factors including temperature and absolute humidity. Correlation and regression analyses were conducted to explore the relationship between RSV seasonality and study methods and characteristics of study locations. Results: RSV seasons were reported in 209 articles published in 1973-2023 for 317 locations in 77 countries. Variations were identified in types of data, data collection and analytical methods across the studies. Regular RSV seasons were similarly reported in countries in temperate regions, with highly variable seasons identified in subtropical and tropical countries. Durations of RSV seasons were relatively longer in subtropical and tropical regions than from temperate regions. Longer durations of RSV seasons were associated with a higher daily average mean temperature and daily average mean absolute humidity. Conclusions: The global seasonal patterns of RSV provided important information for optimizing interventions against RSV infection. Heterogeneity in study methods highlighted the importance of developing and applying standardized approaches in RSV surveillance and data reporting.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.12.23291266v1" target="_blank">Global seasonal activities of respiratory syncytial virus before the COVID-19 pandemic: a systematic review</a>
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<li><strong>Lifespan of COVID-19 living guideline recommendations: a survival analysis</strong> -
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Background NICE has maintained a portfolio of COVID-19 living guidelines since March 2020. Recommendations within these living guidelines are subject to continuous surveillance and updates in response to triggers. However, the lifespan of individual living guideline recommendations and features that may impact on whether a recommendation becomes out of date sooner, is unknown. Objectives This study aimed to describe the length of time NICE COVID-19 living guideline recommendations have remained valid. Methods All guidelines within the NICE COVID-19 portfolio were included to determine the lifespan of living guideline recommendations. Data were collected on all recommendations that had been developed, undergone surveillance or updated between 1 March 2020 and 31 August 2022. Information on initial publication date, decision to update, and update publication date was extracted. Updates were labelled as major changes in evidence synthesis or minor changes without a substantial change in evidence base. Any recommendation that had not been updated or withdrawn was censored. Survival analysis (Kaplan-Meier Curve) was carried out to determine the lifespan of recommendations. Results Overall, 26 COVID-19 living guidelines and 1182 recommendations were included in the analysis. Living recommendations had median survival time of 739 days (IQR: 332, 781). Based on recommendation type, intervention recommendations had a shorter survival time (354 days, IQR 312, 775) compared to diagnosis (368 days, IQR: 328, 795), patient experience (733 days, IQR: 345, 795) and service delivery (739 days, IQR: 643, 781). Within intervention type, pharmacological recommendations had shortest survival time versus non-pharmacological recommendations [335 days (IQR: 161, 775) vs 775 days (IQR: 354, 775)]. Updates were published an average of 29.12 days following a surveillance decision. Conclusion Within living guidelines, some recommendations need to be updated sooner than others. This study outlines the value of a flexible responsive approach to surveillance within the living mode according to pace of change and expectation of update triggers.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.08.23291123v1" target="_blank">Lifespan of COVID-19 living guideline recommendations: a survival analysis</a>
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<li><strong>SARS-CoV-2 Spread Under the Controlled-Distancing Model of Rio Grande do Sul, Brazil</strong> -
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In early 2020, the government of Rio Grande do Sul established a public-health assessment-response framework to halt the spread of SARS-CoV-2, called 9controlled-distancing model9 (CDM). This framework subdivided the state in 21 regions where it evaluated a composite index of disease transmission and health-service capacity. Updated on a weekly basis, the index placed regions on a color-coded scale of flags, which guided adoption of non-pharmaceutical interventions. We aim to evaluate the extent to which the CDM accurately assessed transmission and the effectiveness of its responses throughout 2020. We estimated the weekly effective reproduction number (<i>R<sub>t</sub></i>) of SARS-CoV-2, for each region, using a renewal-equation-based statistical model of notified COVID-19 deaths. Using <i>R<sub>t</sub></i> estimates, we explored whether flag colors assigned by the CDM either reflected or affected SARS-CoV-2 dissemination. Flag assignments did reflect variations in <i>R<sub>t</sub></i>, to a limited extent, but we found no evidence that they affected <i>R<sub>t</sub></i> in the short term. Medium-term effects were apparent in only four regions after eight or more weeks of red-flag assignment. Analysis of Google movement metrics showed no evidence that people moved differently under different flags. The dissociation between flag colors and the propagation of SARS-CoV-2 does not support the claim that non-pharmaceutical interventions are ineffective. Our results show, however, that decisions made under the CDM framework were ineffective both for influencing the movement of people and for halting the spread of the virus.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.09.23291044v1" target="_blank">SARS-CoV-2 Spread Under the Controlled-Distancing Model of Rio Grande do Sul, Brazil</a>
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<li><strong>Characteristics and outcomes of patients with COVID-19 at high risk of disease progression receiving sotrovimab, oral antivirals or no treatment in Scotland</strong> -
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Introduction: Severe acute respiratory syndrome coronavirus 2 is constantly evolving. The clinical benefit of coronavirus disease 2019 (COVID-19) treatments against new circulating variants remains unclear. We sought to describe the real-world use of, and clinical outcomes associated with, early COVID-19 treatments among non-hospitalised patients with COVID-19 at highest risk of developing severe disease in Scotland. Methods: Retrospective cohort study of non-hospitalised patients diagnosed with COVID-19 from 1 December 2021 to 25 October 2022, using administrative health data managed by Public Health Scotland and National Records of Scotland. Patients included in the study were aged ≥18 years, met at least one of the National Health Service highest-risk conditions criteria for early COVID-19 treatment, and had received outpatient treatment with sotrovimab, nirmatrelvir/ritonavir or molnupiravir, or no early COVID-19 treatment. Index date was defined as the earliest of either COVID-19-positive diagnosis or early COVID-19 treatment during the study period. Baseline patient characteristics and acute clinical outcomes in the 28 days following the index date were reported. To protect patient confidentiality, values of ≤5 were suppressed. Results: A total of 2548 patients were included (492: sotrovimab, 276: nirmatrelvir/ritonavir, 71: molnupiravir, and 1709 eligible highest-risk untreated). Patients aged ≥75 years accounted for 6.9% (n=34/492) of the sotrovimab-treated group, 21.0% (n=58/276) of those treated with nirmatrelvir/ritonavir, 16.9% (n=12/71) of those treated with molnupiravir and 13.2% (n=225/1709) of untreated patients. Advanced renal disease was reported for 6.7% (n=33/492) of sotrovimab-treated and 4.7% (n=81/1709) of untreated patients, and five or fewer patients in the nirmatrelvir/ritonavir and molnupiravir cohorts. A high proportion of treated patients did not have a highest-risk condition reported in the database (71.7% for sotrovimab [n=353/492], 85.1% for nirmatrelvir/ritonavir [n=235/276], 85.9% for molnupiravir [n=61/71]). Five or fewer patients in each treated cohort experienced COVID-19-related hospitalisations during the 28-day acute period. For untreated patients, the percentage of COVID-19-related hospitalisations was 3.0% (n=48/1622). All-cause hospitalisations were experienced by 5.3% (n=25/476) of sotrovimab-treated patients, 6.9% (n=12/175) of nirmatrelvir/ritonavir-treated patients and 13.3% (n=216/1622) of untreated patients. Five or fewer patients in the molnupiravir cohort experienced all-cause hospitalisation. There were no deaths within 28 days of index for patients in the treated cohorts. Mortality was 4.3% (n=70/1622) in untreated patients (18.6% [n=13/70] had COVID-19 as the primary cause). In our analyses of outcomes for sotrovimab-treated and untreated patients during BA.1, BA.2 and BA.5 predominance, COVID-19-related hospitalisation rates were consistent, with n≤5 for sotrovimab-treated patients in each period. Conclusions: Our findings indicate that sotrovimab was often used amongst patients who were aged &lt;75 years old and had advanced renal disease. Among patients who received early COVID-19 treatment, proportions of all-cause hospitalisation and death within 28 days of treatment were low.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.09.23291195v1" target="_blank">Characteristics and outcomes of patients with COVID-19 at high risk of disease progression receiving sotrovimab, oral antivirals or no treatment in Scotland</a>
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<li><strong>SARS-CoV-2 seroprevalence in pregnant women during the first three COVID-19 waves in The Gambia</strong> -
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Objectives SARS-CoV-2 transmission in Sub-Saharan Africa has probably been underestimated. Population-based seroprevalence studies are needed to determine the extent of transmission in the continent. Methods Blood samples from a cohort of Gambian pregnant women were tested for SARS-CoV-2 total IgM/IgG before (Pre-pandemic1: October-December 2019 and Pre-pandemic2: February-June 2020) and during the pandemic (Post-wave1: October-December 2020, Post-wave2: May-June 2021; and Post-wave3: October-December 2021). Samples positive for total SARS-CoV-2 IgM/IgG were tested for protein-specific antibodies. Results SARS-CoV-2 total IgM/IgG seroprevalence was 0.9% 95%CI (0.2, 4.9) in Pre-pandemic1; 4.1% (1.4, 11.4) in Pre-pandemic2; 31.1% (25.2, 37.7) in Post-wave1; 62.5% (55.8, 68.8) in Post-wave2 and 90.0% (85.1, 93.5) in Post-wave3. S-protein IgG and NCP-protein IgG seroprevalence also increased at each Post-wave period. Although S-protein IgG and NCP-protein IgG seroprevalence was similar at Post-wave1, S-protein IgG seroprevalence was higher at Post-wave2 and Post-wave3, [prevalence difference (PD) 13.5 (0.1, 26.8) and prevalence ratio (PR) 1.5 (1.0, 2.3) in Post-wave2; and 22.9 (9.2, 36.6) and 1.4 (1.1, 1.8) in Post-wave3 respectively, p&lt;0.001]. Conclusion SARS-CoV-2 transmission in The Gambia during the first three COVID-19 waves was high, differing significantly from official numbers of COVID-19 cases reported. Our findings are important for policy makers in managing the near-endemic COVID-19.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.09.23291201v1" target="_blank">SARS-CoV-2 seroprevalence in pregnant women during the first three COVID-19 waves in The Gambia</a>
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<li><strong>User adherence and perceptions of a Volunteer-Led Telemonitoring and Teleorientation Service for COVID-19 community management in Peru: The COVIDA project</strong> -
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Background: During the pandemic in Peru, the COVIDA project proposed an innovative way to provide telemonitoring and teleorientation to COVID-19 pandemics led by health student volunteers. However, it has not been described how this interaction is perceived from the user9s perspective. The aim of this study is to describe the adherence and perceptions of users about COVIDA. Methods: A mixed-method study was conducted to evaluate the adherence and perceptions of COVIDA users. This telehealth intervention implemented in Peru from August to December 2020 involved daily phone-calls by volunteer students to monitor registered users for 14 days or until a warning sign was identified. The volunteers also provided teleorientation to address the users9 needs and concerns. Quantitative analysis described the characteristics of users and assessed the factors related to adherence to the service. Qualitative analysis trough semi-structured interviews evaluated the user9s perceptions about the service. Results: Of the 778 users enrolled in COVIDA, 397 (54.7%) were female and had a mean age of 41 years (SD: 15.3). During the monitoring, 380 users (44.4%) developed symptoms, and 471 (55.5%) showed warning signs for COVID-19. The overall median of adherence was 93% (p25:36%, p75:100%). Among those users who did not develop warning symptoms, a high level of adherence (&gt;66%) was seen predominantly in users that developed symptoms and those with a positive COVID-19 test (p&lt;0.05). Users referred that the information provided by volunteers was clear and valuable and, their accompaniment provided them with emotional support. Communications via phone calls were developed fluently without interruptions. Conclusions: COVIDA represented an affordable, well-accepted, and perceived alternative model for telemonitoring, teleorientation and emotional support from student volunteers to users with diseases such as COVID-19 in a context of overwhelmed demand for healthcare services.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.08.23291037v1" target="_blank">User adherence and perceptions of a Volunteer-Led Telemonitoring and Teleorientation Service for COVID-19 community management in Peru: The COVIDA project</a>
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<li><strong>Poor immunogenicity upon SARS-CoV-2 mRNA vaccinations in autoimmune SLE patients is associated with pronounced EF-mediated responses and anti-BAFF/Belimumab treatment.</strong> -
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Novel mRNA vaccines have resulted in a reduced number of SARS-CoV-2 infections and hospitalizations. Yet, there is a paucity of studies regarding their effectiveness on immunocompromised autoimmune subjects. In this study, we enrolled subjects naive to SARS- CoV-2 infections from two cohorts of healthy donors (HD, n=56) and systemic lupus erythematosus (SLE, n=69). Serological assessments of their circulating antibodies revealed a significant reduction of potency and breadth of neutralization in the SLE group, only partially rescued by a 3rd booster dose. Immunological memory responses in the SLE cohort were characterized by a reduced magnitude of spike-reactive B and T cell responses that were strongly associated with poor seroconversion. Vaccinated SLE subjects were defined by a distinct expansion and persistence of a DN2 spike-reactive memory B cell pool and a contraction of spike-specific memory cTfh cells, contrasting with the sustained germinal center (GC)-driven activity mediated by mRNA vaccination in the healthy population. Among the SLE-associated factors that dampened the vaccine responses, treatment with the monoclonal antibody anti-BAFF/Belimumab (a lupus FDA- approved B cell targeting agent) profoundly affected the vaccine responsiveness by restricting the de novo B cell responses and promoting stronger extra-follicular (EF)-mediated responses that were associated with poor immunogenicity and impaired immunological memory. In summary, this study interrogates antigen-specific responses and characterized the immune cell landscape associated with mRNA vaccination in SLE. The identification of factors associated with reduced vaccine efficacy illustrates the impact of SLE B cell biology on mRNA vaccine responses and provides guidance for the management of boosters and recall vaccinations in SLE patients according to their disease endotype and modality of treatment.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.08.23291159v1" target="_blank">Poor immunogenicity upon SARS-CoV-2 mRNA vaccinations in autoimmune SLE patients is associated with pronounced EF-mediated responses and anti-BAFF/Belimumab treatment.</a>
</div></li>
<li><strong>Naked-eye Detection of LAMP-Produced Nucleic Acids in Saliva using Chitosan-capped AuNPs in a Single-Tube Assay</strong> -
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Loop-mediated isothermal amplification (LAMP) is a low-technology molecular assay highly adaptable to point-of-care (POC) applications. However, achieving sensitive naked-eye detection of the amplified target in a crude sample is challenging. Herein, we report a simple, yet highly efficient and sensitive methodology for the colorimetric visualization of a single target copy in saliva, using chitosan-capped gold nanoparticles (Chit-AuNPs) synthesized via a green-chemistry approach. The presence or absence of free Chit in the Chit-AuNPs solution was shown to affect LAMP colorimetric detection oppositely: the observed stabilization in the negative samples and aggregation in the positive samples in the presence of free Chit was reversed in the case of neat Chit-AuNPs. The mechanism of the two assays was investigated and attributed to electrostatic and depletion effects exerted between the Chit-AuNPs, free Chit and the solution components. The developed contamination-free, one-tube assay successfully amplified and detected down to 1-5 cfu of Salmonella and 10 copies of SARS-CoV-2 per reaction (25 uL) in the presence of 20% saliva, making the method suitable for POC applications. Compared to the commonly used pH sensitive dyes, Chit-AuNPs are shown to have an enhanced sensitivity toward the naked-eye colorimetric observation owing to the direct detection of DNA amplicons. Thus, this is a simple, highly sensitive, fast and versatile naked-eye detection methodology that could be coupled to any LAMP or RT-LAMP assay, avoiding the need of using complicated sample pretreatments and/or AuNPs long and laborious functionalization processes.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.06.09.23291198v1" target="_blank">Naked-eye Detection of LAMP-Produced Nucleic Acids in Saliva using Chitosan-capped AuNPs in a Single-Tube Assay</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Extracorporeal Photopheresis as a Possible Therapeutic Approach to Adults With Severe and Critical COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Procedure: Extracorporeal photopheresis<br/><b>Sponsor</b>:   Del-Pest Central Hospital - National Institute of Hematology and Infectious Diseases<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Clinical Trial on Booster Immunization of Two COVID-19 Vaccines Constructed From Different Technical Routes</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Prototype and Omicron BA.4/5 Bivalent Recombinant COVID-19 Vaccine(Adenovirus Type 5 Vector) For Inhalation;   Biological: Bivalent COVID-19 mRNA Vaccine;   Biological: Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) For Inhalation<br/><b>Sponsors</b>:   Zhongnan Hospital;   Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Community-engaged Optimization of COVID-19 Rapid Evaluation And TEsting Experiences</strong> - <b>Conditions</b>:   COVID-19;   COVID-19 Pandemic<br/><b>Interventions</b>:   Behavioral: COVID-19 walk-up, on-site testing strategy;   Behavioral: Community Health Worker (CHW) leading testing navigation and general preventive care reminders;   Behavioral: No-cost self-testing kit vending machines<br/><b>Sponsors</b>:   University of California, San Diego;   San Ysidro Health Center<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety Study of COVID19 Vaccine on the Market</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Recombinant new coronavirus vaccine (CHO cell)<br/><b>Sponsors</b>:   Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.;   Hunan Provincial Center for Disease Control and Prevention;   Guizhou Center for Disease Control and Prevention;   Hainan Center for Disease Control &amp; Prevention<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACTIV-6: COVID-19 Study of Repurposed Medications - Arm F (Montelukast)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Placebo;   Drug: Montelukast<br/><b>Sponsors</b>:   Susanna Naggie, MD;   National Center for Advancing Translational Sciences (NCATS);   Vanderbilt University Medical Center<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACTIV-6: COVID-19 Study of Repurposed Medications - Arm B (Fluvoxamine)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Fluvoxamine;   Other: Placebo<br/><b>Sponsors</b>:   Susanna Naggie, MD;   National Center for Advancing Translational Sciences (NCATS);   Vanderbilt University Medical Center<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACTIV-6: COVID-19 Study of Repurposed Medications - Arm D (Ivermectin 600)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Ivermectin;   Other: Placebo<br/><b>Sponsors</b>:   Susanna Naggie, MD;   National Center for Advancing Translational Sciences (NCATS);   Vanderbilt University Medical Center<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Fluvoxamine;   Other: Placebo<br/><b>Sponsors</b>:   Susanna Naggie, MD;   National Center for Advancing Translational Sciences (NCATS);   Vanderbilt University Medical Center<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of Home Use COVID-19 Frequent Antigen Testing and Data Reporting</strong> - <b>Condition</b>:   COVID-19 Respiratory Infection<br/><b>Intervention</b>:   Diagnostic Test: SARS CoV-2 antigen tests<br/><b>Sponsors</b>:   IDX20 Inc;   National Institute on Minority Health and Health Disparities (NIMHD)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19</strong> - <b>Conditions</b>:   SARS-CoV Infection;   COVID-19<br/><b>Interventions</b>:   Drug: Mitoquinone/mitoquinol mesylate;   Other: Placebo<br/><b>Sponsor</b>:   University of Texas Southwestern Medical Center<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pycnogenol® in Post-COVID-19 Condition</strong> - <b>Conditions</b>:   Post COVID-19 Condition;   Long COVID<br/><b>Interventions</b>:   Drug: Pycnogenol®;   Drug: Placebo<br/><b>Sponsor</b>:   University of Zurich<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Bailing Capsule on Pulmonary Fibrosis After COVID-19</strong> - <b>Conditions</b>:   Pulmonary Fibrosis;   COVID-19 Pneumonia<br/><b>Intervention</b>:   Drug: Bailing capsule<br/><b>Sponsor</b>:   Second Affiliated Hospital, School of Medicine, Zhejiang University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating Emetine for Viral Outbreaks (EVOLVE)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Emetine Hydrochloride;   Drug: Placebo<br/><b>Sponsors</b>:   Johns Hopkins University;   Nepal Health Research Council;   Bharatpur Hospital Chitwan;   Stony Brook University;   Rutgers University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>To Evaluate the Immunogenicity and Safety of Sequential Booster Immunization of Recombinant Novel Coronavirus Vaccine (CHO Cells) for SARS-CoV-2</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Recombinant Novel Coronavirus vaccine (CHO Cells)<br/><b>Sponsor</b>:   Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883.</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: PF-07817883<br/><b>Sponsor</b>:   Pfizer<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antibody responses to mRNA versus non-mRNA COVID vaccines among the Mongolian population</strong> - CONCLUSIONS: The BNT162b2 vaccine showed the highest level of antibody against SARS-CoV-2, followed by the BBIBP-CorV, Gam-COVID-Vac, and ChAdOx1 n-CoV-19 vaccines. The level of antibodies was increased in people infected with SARS-CoV-2 after vaccination, as compared to uninfected but vaccinated individuals.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibiting C5 in patients with severe COVID-19-the incorrect target? - Authors’ reply</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibiting C5 in patients with severe COVID-19-the incorrect target?</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacological properties and derivatives of saikosaponins-a review of recent studies</strong> - CONCLUSIONS: An increasing amount of data have indicated diverse SS pharmacological properties, indicating crucial clues for future studies and the production of novel saikosaponin-based anti-inflammatory, efficacious anticancer, and anti-novel-coronavirus agents with improved efficacy and reduced toxicity.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Applications of advances in mRNA-based platforms as therapeutics and diagnostics in reproductive technologies</strong> - The recent COVID-19 pandemic led to many drastic changes in not only society, law, economics, but also in science and medicine, marking for the first time when drug regulatory authorities cleared for use mRNA-based vaccines in the fight against this outbreak. However, while indeed representing a novel application of such technology in the context of vaccination medicine, introducing RNA into cells to produce resultant molecules (proteins, antibodies, etc.) is not a novel principle. It has been…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biotransformation and brain distribution of the anti-COVID-19 drug molnupiravir and herb-drug pharmacokinetic interactions between the herbal extract Scutellaria formula-NRICM101</strong> - The aim of this study was to explore the effects of herbal drug pharmacokinetic interactions on the biotransformation of molnupiravir and its metabolite β-D-N4-hydroxycytidine (NHC) in the blood and brain. To investigate the biotransformation mechanism, a carboxylesterase inhibitor, bis(4-nitrophenyl)phosphate (BNPP), was administered. Not only molnupiravir but also the herbal medicine Scutellaria formula-NRICM101 is potentially affected by coadministration with molnupiravir. However, the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium</strong> - Repurposing existing drugs to inhibit SARS-CoV-2 infection in airway epithelial cells (AECs) is a quick way to find novel treatments for COVID-19. Computational screening has found dicoumarol (DCM), a natural anticoagulant, to be a potential SARS-CoV-2 inhibitor, but its inhibitory effects and possible working mechanisms remain unknown. Using air-liquid interface culture of primary human AECs, we demonstrated that DCM has potent antiviral activity against the infection of multiple Omicron…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Binding properties of selective inhibitors of P323L mutated RdRp of SARS-CoV-2: a combined molecular screening, docking and dynamics simulation study</strong> - Since 2019 the SARS-CoV-2 and its variants caused COVID-19, such incidents brought the world in pandemic situation. This happened due to furious mutations in SARS-CoV-2, in which some variants had high transmissibility and infective, this led the virus emerged as virulent and worsened the COVID-19 situation. Among the variants, P323L is one of the important mutants of RdRp in SARS-CoV-2. To inhibit the erroneous function of this mutated RdRp, we have screened 943 molecules against the P323L…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of Flavonoids from <em>Scutellaria barbata</em> D. Don as Inhibitors of HIV-1 and Cathepsin L Proteases and Their Structure-Activity Relationships</strong> - Scutellaria barbata D. Don (SB, Chinese: Ban Zhi Lian), a well-known medicinal plant used in traditional Chinese medicine, is rich in flavonoids. It possesses antitumor, anti-inflammatory, and antiviral activities. In this study, we evaluated the inhibitory activities of SB extracts and its active components against HIV-1 protease (HIV-1 PR) and SARS-CoV2 viral cathepsin L protease (Cat L PR). UPLC/HRMS was used to identify and quantify the major active flavonoids in different SB extracts, and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Docking-Based Evidence for the Potential of ImmunoDefender: A Novel Formulated Essential Oil Blend Incorporating Synergistic Antiviral Bioactive Compounds as Promising Mpro Inhibitors against SARS-CoV-2</strong> - Essential oils (Eos) have demonstrated antiviral activity, but their toxicity can hinder their use as therapeutic agents. Recently, some essential oil components have been used within safe levels of acceptable daily intake limits without causing toxicity. The “ImmunoDefender,” a novel antiviral compound made from a well-known mixture of essential oils, is considered highly effective in treating SARS-CoV-2 infections. The components and doses were chosen based on existing information about their…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Luteolin Isolated from <em>Juncus acutus</em> L., a Potential Remedy for Human Coronavirus 229E</strong> - The COVID-19 pandemic, caused by SARS-CoV-2, addressed the lack of specific antiviral drugs against coronaviruses. In this study, bioguided fractionation performed on both ethyl acetate and aqueous sub-extracts of Juncus acutus stems led to identifying luteolin as a highly active antiviral molecule against human coronavirus HCoV-229E. The apolar sub-extract (CH(2)Cl(2)) containing phenanthrene derivatives did not show antiviral activity against this coronavirus. Infection tests on Huh-7 cells,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pro- and Anti-Inflammatory Prostaglandins and Cytokines in Humans: <em>A Mini Review</em></strong> - Inflammation has been described for two millennia, but cellular aspects and the paradigm involving different mediators have been identified in the recent century. Two main groups of molecules, the prostaglandins (PG) and the cytokines, have been discovered and play a major role in inflammatory processes. The activation of prostaglandins PGE2, PGD2 and PGI2 results in prominent symptoms during cardiovascular and rheumatoid diseases. The balance between pro- and anti-inflammatory compounds is…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Free Light Chains <em>κ</em> and <em>λ</em> as New Biomarkers of Selected Diseases</strong> - Diagnostic and prognostic markers are necessary to help in patient diagnosis and the prediction of future clinical events or disease progression. As promising biomarkers of selected diseases, the free light chains (FLCs) κ and λ were considered. Measurements of FLCs are currently used in routine diagnostics of, for example, multiple myeloma, and the usefulness of FLCs as biomarkers of monoclonal gammopathies is well understood. Therefore, this review focuses on the studies concerning FLCs as new…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eupatin, a Flavonoid, Inhibits Coronavirus 3CL Protease and Replication</strong> - The coronavirus disease 2019 (COVID-19) pandemic has caused more than six million deaths worldwide since 2019. Although vaccines are available, novel variants of coronavirus are expected to appear continuously, and there is a need for a more effective remedy for coronavirus disease. In this report, we isolated eupatin from Inula japonica flowers and showed that it inhibits the coronavirus 3 chymotrypsin-like (3CL) protease as well as viral replication. We showed that eupatin treatment inhibits…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of low-intensity pulsed ultrasound for the treatment of viral pneumonia: study protocol for a randomized controlled trial</strong> - BACKGROUND: Viral pneumonia has always been a problem faced by clinicians because of its insidious onset, strong infectivity, and lack of effective drugs. Patients with advanced age or underlying diseases may experience more severe symptoms and are prone to severe ventilation dysfunction. Reducing pulmonary inflammation and improving clinical symptoms is the focus of current treatment. Low-intensity pulsed ultrasound (LIPUS) can mitigate inflammation and inhibit edema formation. We aimed to…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Will the Judge in Trump’s Case Recuse Herself—or Be Forced To?</strong> - Federal law requires a judge to step away from a case in which her impartiality “might reasonably be questioned.” - <a href="https://www.newyorker.com/news/q-and-a/will-the-judge-in-trumps-case-recuse-herself-or-be-forced-to">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Most Belligerent Flack on Capitol Hill</strong> - Nick Dyer, the deputy chief of staff to Marjorie Taylor Greene, has built a career as a political aide out of what one observer calls “pure, non-strategic contempt.” - <a href="https://www.newyorker.com/news/letter-from-the-south/the-most-belligerent-flack-on-capitol-hill">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What We Can Learn from London’s Smoke-Filled Skies</strong> - Hazardous health conditions in Dickensian England led to meaningful governmental reform. - <a href="https://www.newyorker.com/news/daily-comment/what-we-can-learn-from-londons-smoke-filled-skies">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Israel’s Government Is Attacking Its Public-Broadcasting System</strong> - Benjamin Netanyahu’s coalition is going after élite institutions, and that’s not good for democracy. - <a href="https://www.newyorker.com/news/daily-comment/why-israels-government-is-attacking-its-public-broadcasting-system">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What Was Nate Silver’s Data Revolution?</strong> - Silver, a former professional poker player, was in the business of measuring probabilities. Many readers mistook him for an oracle. - <a href="https://www.newyorker.com/news/our-columnists/what-was-nate-silvers-data-revolution">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Why another indictment isn’t hurting Trump in the 2024 primary</strong> -
<figure>
<img alt="A hand waving a “Trump 2024” flag." src="https://cdn.vox-cdn.com/thumbor/HJ0sI8IYvAyLYihwO4tNuHJyLgc=/667x0:6000x4000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72365382/1497710911.0.jpg"/>
<figcaption>
Supporters of former President Donald Trump gather near his Mar-a-Lago home after he was indicted on a new set of charges related to the mishandling of classified documents on June 11, 2023, in Palm Beach, Florida. | Scott Olson/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
How many times does Trump have to be indicted before Republican voters notice?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1LRnlY">
After his first indictment, former <a href="https://www.vox.com/donald-trump">President Donald Trump</a> increased his lead in the polls over his 2024 Republican rivals. Now, in the wake of his <a href="https://www.vox.com/politics/2023/6/9/23755468/trump-jail-criminal-indictment-explained-espionage-cannon">second indictment</a>, it’s begun to appear that even federal charges won’t hurt his campaign.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xZHeuY">
Many GOP strategists say that most Republican primary voters already drew their battlelines on Trump long ago, meaning this indictment (for allegedly refusing to return classified documents to federal authorities after he left the White House) doesn’t change anything. That tracks with a <a href="https://www.cbsnews.com/news/cbs-news-poll-most-see-security-risk-after-trump-indictment/">CBS News poll</a> conducted June 9 and 10 — right after news of the indictment broke — that found 76 percent of likely Republican primary voters thought that the indictment was politically motivated and 61 percent said it didn’t change their views on Trump.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WcAbt2">
“At least in terms of the primary, this certainly is not likely to impact President Trump’s chances of getting the nomination,” said Matt Terrill, former chief of staff to Florida Republican Sen. Marco Rubio when he ran for president.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PLaKu2">
But other strategists say that sentiments could change as the severity of the indictment and what it means for Trump’s electability sink in, especially among those in the party that GOP pollster Whit Ayres calls the “Maybe Trump” voters: people who like the former president, but also want someone who can win.
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“Will the Trump pushback that this is all a partisan witch hunt be persuasive to them?” he asked. “Or will the devastating facts laid out in the indictment persuade at least some of them that Trump is carrying way too much baggage to win a general election in 2024?”
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For now, he said, it’s too early to tell.
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<h3 id="s0FQrc">
This indictment feels different, but Trump supporters might not care
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EnUqqH">
It might be harder to pass off the <a href="https://www.vox.com/2023/6/9/23755679/indictment-unsealed-trump-charges-explained-classified-documents">damning details of this indictment</a> as simply motivated by politics than it was for Trump and his supporters to dismiss his April indictment. That case concerned hush money payments to the adult film star Stormy Daniels during his 2016 campaign, and hinged on what <a href="https://www.vox.com/politics/2023/4/4/23648390/trump-indictment-supreme-court-stormy-daniels-manhattan-alvin-bragg">my colleague Ian Millhiser</a> described as a “dubious legal theory.” This time, even some prominent Republican figures, including Trump’s <a href="https://twitter.com/FoxNewsSunday/status/1667899493549764608?s=20">former US Attorney General Bill Barr</a>, have argued that the case should be taken seriously.
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“If I were designing a legal case that would be easy for Republicans to dismiss as a partisan witch hunt, I would design exactly the case that [Manhattan District Attorney] Alvin Bragg brought,” Ayres said. On the other hand, he added, Trump’s latest indictment is “a devastating critique of the handling of highly sensitive classified information that most people would admit would get any other human being alive today charged with multiple felonies.”
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The problem is, Trump’s supporters might not be willing to hear that — especially when that messaging is coming from people like Barr, who they haven’t perceived as being on their side for years.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qbapLk">
“Many [Republican] voters have a growing distrust of the Justice Department or the government,” Terrill said. “A lot of these voters … look at President Trump as an individual who’s the biggest truth-teller that they’ve seen in Washington.”
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Many in Trump’s camp also are unconcerned with the merits of the case, making them difficult to sway. They’re arguing that Trump is subject to a double standard compared to other officials who’ve mishandled sensitive documents, including former Vice President <a href="https://www.vox.com/mike-pence">Mike Pence</a>, 2016 Democratic presidential nominee <a href="https://www.vox.com/hillary-clinton">Hillary Clinton</a>, and <a href="https://www.vox.com/joe-biden">President Joe Biden</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1nke7p">
In recent months, classified documents were found in Biden’s personal Washington office and at his Delaware home, as well as at Pence’s home in Indiana. Clinton used a private, unsecured email server while serving as secretary of state that stored discussions of classified information (but not classified documents themselves). The difference, which hasn’t been acknowledged by Trump’s backers, is that Biden and Pence promptly turned over those documents; Clinton faced no charges, and there is no evidence that Biden, Pence, or Clinton willfully <a href="https://www.washingtonpost.com/national-security/2023/06/11/clinton-biden-classified-documents-trump-indictment/">sought to obstruct justice</a>.
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“It’s almost like they’re putting their heads in the sand to avoid the obvious distinctions between this case and the Pence, Biden, and Clinton cases,” Ayres said. “They can’t defend what he did. No one is defending what he did.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r6GprK">
But even if Republican voters think the allegations against Trump are true, they might not believe them to be a dealbreaker in a matchup against Biden.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uGXyUi">
“I run into Trump supporters who think these investigations would not stop him from beating Biden,” GOP pollster Robert Cahaly said. “Biden is so unpopular. Biden also has personal baggage related to investigations and the <a href="https://www.vox.com/economy">economy</a>. He’s still beatable.”
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<h3 id="ptqpOg">
Trump’s GOP rivals mostly aren’t acting like anything has changed
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BIqiAZ">
For the most part, Trump’s GOP rivals don’t seem to think that the indictment has given them an opening in a race where Trump has been the clear frontrunner for months. Those who weren’t already running an explicitly anti-Trump platform haven’t revised their strategy of largely refraining from criticizing the former president.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yQzJN6">
<a href="https://www.vox.com/ron-desantis">Florida Gov. Ron DeSantis</a>, South Carolina Sen. Tim Scott, and right-wing activist Vivek Ramaswamy all railed against what they described as a <a href="https://www.cbsnews.com/news/republican-responses-to-trump-indictment/">biased criminal justice system</a> for delivering the indictment but didn’t comment on the specific allegations against Trump. Even former Vice President Mike Pence, who has been forthcoming about cutting ties with Trump over his handling of the January 6, 2021, insurrection, <a href="https://www.cbsnews.com/news/republican-responses-to-trump-indictment/">said</a> he was “deeply troubled to see this indictment move forward.”
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The exception is Trump’s former US ambassador to the UN, Nikki Haley, who <a href="https://twitter.com/katesullivandc/status/1668346965384646656?s=46&amp;t=fTBbgr0idAmuCqR9cje80A">said</a> on Fox News Monday that if the allegations against Trump are true, he was “incredibly reckless with our <a href="https://www.vox.com/defense-and-security">national security</a>.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JgO71F">
The question is whether more candidates and Republican voters will join her in the weeks and months ahead as the case, which may not be decided until after the <a href="https://www.vox.com/2024-presidential-election">2024 election</a>, proceeds. With <a href="https://www.vox.com/2024-presidential-election/2023/6/9/23754364/christie-pence-burgum-president-2024-election">so many Republicans</a> trying to break through in a crowded field, more candidates may try to seize on the argument that this indictment makes Trump less electable.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZLYVQ1">
Those attacks may ultimately prove ineffective, however, given the strength of Trump’s support, Terrill said. “There are many Republican voters and many donors who believe that President Trump is the nominee that they want, and believe that he can win the general election,” he said.
</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Blue states’ “shield laws” for abortion and trans health care, explained</strong> -
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<img alt="Protester holding a sign that says “rise up 4 women in Tennessee” beside another with a sign that reads “rise up 4 women in Texas.”" src="https://cdn.vox-cdn.com/thumbor/IBYZJFagIJaQ1Pgit9kl-MZSAa0=/334x0:5667x4000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72365324/1446116736.0.jpg"/>
<figcaption>
Abortion rights activists protest at the federal building plaza in Chicago, Illinois, in December 2022. Illinois is one of five states that has passed “shield laws” meant to protect abortion and gender-affirming care. | Scott Olson/Getty Images
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
State legislatures are trying to legally protect patients’ ability to receive care in their state.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CMKlPD">
<em>This story was originally published by </em><a href="https://19thnews.org/2023/06/abortion-trans-health-care-shield-laws/"><em>The 19th</em></a><em>. </em><a href="https://19thnews.org/newsletters"><em>Sign up for their daily newsletter</em></a><em>.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cLLhYp">
Blue states are crafting a new kind of legislation to respond to a dramatic wave of restrictions on <a href="https://19thnews.org/2023/05/abortion-bans-unpopular-republicans-passing-them-anyway/">abortion access</a> and gender-affirming care across the country. Democrats are invoking the fall of <a href="https://www.vox.com/2022/5/3/23055125/roe-v-wade-abortion-rights-supreme-court-dobbs-v-jackson"><em>Roe v. Wade</em></a> as a reason to protect both areas of <a href="https://www.vox.com/health-care">health care</a> simultaneously — while aiming to create safe havens for those fleeing surrounding Republican-controlled states.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uaCeOI">
Lawmakers in five states — Illinois, New Mexico, Colorado, Washington, and Vermont, which has a Republican governor although Democrats control the state legislature — plus the District of Columbia have enacted such “shield” laws so far this year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nBv1jZ">
Connecticut and Massachusetts were the first states to pass this type of shield bill into law last year, according to the Movement Advancement Project, which tracks <a href="https://www.vox.com/lgbtq">LGBTQ</a>+ policy. The laws vary in scope and are still evolving as more states, like <a href="https://apnews.com/article/abortion-gender-affirming-care-oregon-legislature-da96e44656687d8e35ce0ffac2f809c1">Oregon</a> and <a href="https://www.billtrack50.com/billdetail/1500820/">California</a>, introduce their own bills to explicitly combine protections for gender-affirming care and abortion.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cVRvv1">
However, the unifying theme is that they aim to legally protect patients’ ability to receive care in their state — and to protect both providers and patients from being punished. Advocates say that these kinds of protections are crucial as bans on gender-affirming care and abortion evolve in scope and <a href="https://www.thedailybeast.com/health-insurance-for-transgender-care-at-risk-in-tennessee-florida-wyoming-kentucky-and-arkansas">threaten</a> interstate access to care.
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Several states have gone so far as to sign laws protecting patients and doctors <a href="https://www.nmlegis.gov/Sessions/23%20Regular/final/SB0013.pdf">from being arrested</a> if they receive or provide care, to shield them from <a href="https://ilga.gov/legislation/102/HB/10200HB4664enr.htm">aggressive litigation</a>, or to <a href="https://lawfilesext.leg.wa.gov/biennium/2023-24/Pdf/Bills/Session%20Laws/House/1469-S.SL.pdf?q=20230606101858">prevent courts</a> from issuing surveillance orders for investigations into gender-affirming care or abortion procedures.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w7va5Q">
The new push reflects a growing recognition of the fundamental connections between abortion rights and transgender rights by Democratic lawmakers, advocates say, in terms of bodily autonomy and letting doctors make decisions with patients. The bills are a response to the mounting legislative attacks and rhetorical vitriol Republicans are directing toward transgender rights <a href="https://19thnews.org/2023/04/montana-censure-lawmakers-zooey-zephyr-transgender/">in statehouses</a> and <a href="https://www.usatoday.com/story/news/politics/2023/04/20/gop-anti-trans-messaging-2024/11650452002/">on the campaign trail</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TZw5Z4">
“These fights are linked by a really simple belief that each of us are the rightful authors of our own life stories,” said Arli Christian, a campaign strategist focused on LGBTQ+ rights at the American Civil Liberties Union (ACLU). “Each of us has the freedom to determine our path in life, each of us has the right to make decisions about our medical care and our bodies without government interference.”
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Connecticut was the <a href="https://slate.com/news-and-politics/2022/04/connecticuts-abortion-protection-blueprint.html">first state to pass a law</a> protecting from prosecution patients traveling to the state or from civil liability based on laws in their home states, and also shielding Connecticut providers. It did so in April 2022, before the draft leak of the <a href="https://www.vox.com/scotus">Supreme Court</a>’s decision overturning <em>Roe v. Wade</em>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wKlGnA">
“​​We started to put together a suite of protections to essentially make Connecticut a safe haven for safe, legal reproductive health care, including abortion,” said Democratic state Rep. Matt Blumenthal, a co-chair of the legislature’s Reproductive Rights Caucus who drafted and co-sponsored the bill. “And because of the onslaught of laws against gender-affirming care, we included that as well.”
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Connecticut lawmakers also <a href="https://ctnewsjunkie.com/2023/05/19/house-takes-step-to-tighten-protections-for-abortion-providers/">recently passed additional protections</a> shielding providers from <a href="https://19thnews.org/2023/05/caitlin-bernard-indiana-medical-license/">disciplinary sanctions or other penalties</a> for providing abortion or gender-affirming care to patients coming from states where the procedures are illegal.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hvdqz6">
“We were very proud that Connecticut was a leader, and that other states saw us as a model,” Blumenthal said. “We’re a little state, but we punch above our weight.”
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Polly Crozier, director of family advocacy at GLBTQ Legal Advocates &amp; Defenders (GLAD), who has worked with advocates and legislators to advance shield laws, said that Massachusetts’ law to protect gender-affirming care and reproductive health is what first transformed the conversation on how to simultaneously safeguard against restrictive bills.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LU9c8H">
Those safeguards include protections for doctors who provide telehealth to a patient in a state where gender-affirming care or abortion is illegal, plus provisions to protect doctors from being extradited if they provide health care to a patient who traveled from a state with bans in place, Crozier said.
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As more anti-trans bills are signed into law, states are realizing that they need to act to protect health care within their borders, Crozier said — or they risk the destabilizing effects of whole areas of medicine being criminalized.
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<h3 id="DJMhV9">
Blue states shield those who travel for care
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r9eKDq">
Advocates for abortion access and gender-affirming care say these protections are critical, both for residents of the blue states and those in red states who want to travel for care. The types of care are often linked: The closures of clinics that provide abortion often also impacted access to gender-affirming care, especially after the Supreme Court struck down federal abortion protections. In many places, Planned Parenthood’s clinics are the<a href="https://www.npr.org/2022/08/14/1115875421/gender-affirming-care-abortion-clinics"> largest or the sole providers</a> of gender-affirming care.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LbdP9J">
Kimberly Inez McGuire, executive director of URGE, which advocates for reproductive justice with a focus on young people, said the new, increasingly complex legal and political terrain requires viewing health care access “as an ecosystem issue not necessarily confined by state borders.”
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“No one should have to leave the place they love or the people they love in order to be treated like human beings,” she said. “We’re in a time, frankly, of harm reduction, where we can do a lot right to create access in as many places as we can and to protect access.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bGZfvg">
Attempts to ban abortion have a longer history in state legislatures than those to restrict gender-affirming care, and Republican legislators are often borrowing tactics from one and applying them to the other. For example, <a href="https://legiscan.com/MS/text/HB1125/id/2715321">Mississippi’s</a> ban on gender-affirming care prohibits anyone from aiding and abetting patients from receiving gender-affirming care — language similar to <a href="https://19thnews.org/2021/09/texas-new-abortion-law-what-you-need-know/">abortion restrictions passed in Texas</a> before the fall of <em>Roe</em>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oc4oSB">
The evolution of bans on transgender health care means that shield laws that combine protections for abortion and gender-affirming care provide important protections,<strong> </strong>said Logan Casey, senior policy researcher and adviser for the Movement Advancement Project.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gt9p4S">
“We’re seeing language in the gender-affirming health care bans that are explicitly taking language from reproductive health care bans about aiding and abetting,” Casey said, meaning patients traveling <a href="https://apnews.com/article/abortion-trafficking-state-legislature-border-5fc92621bcdb0d7f018d95dd15d6f98c">across state lines</a>, and possibly their friends and family, could be endangered.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sQCOGc">
New bans on abortion and gender-affirming care for youth have placed both forms of care further out of reach, requiring patients in many states to travel farther — if patients have the ability and means to travel at all — and caused physicians in some states to <a href="https://19thnews.org/2023/03/montana-anti-trans-bill-defining-sex/">take their practice elsewhere</a>, depleting health care resources for everyone.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oxa1Xm">
Although advocates are grateful for states creating safe harbors, gender-affirming care is not a procedure, like an abortion, and is individualized — meaning that traveling to get care in a shield law state can be even more difficult, especially for transgender youth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rBkY2A">
Alex Petrovnia, founder and executive director of the Trans Formations Project, a volunteer-run nonprofit that tracks anti-trans bills and has begun to track these kinds of laws more closely, feels hopeful that more people are recognizing the severity of the crisis facing transgender people in the United States. However, having protections in some states is not good enough, he said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="btxdi2">
“If only certain states are protected, and those are states that are more likely to be whiter, wealthier states, we’re abandoning many of the most vulnerable if we say that that’s good enough,” Petrovnia said. “Many trans people do not have the resources or the ability to just up and move.”
</p>
<h3 id="U9B5GH">
Pushback in Oregon
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qHPZVQ">
But the move to tie abortion rights to gender-affirming care has spurred Republicans in Oregon to <a href="https://www.nytimes.com/2023/06/04/us/oregon-legislature-republican-walkout.html">stage an ongoing, now weeks-long walkout</a> that has thrown the statehouse into chaos and ground the legislative process to a halt.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="37BOQA">
In the wake of the Supreme Court overturning <em>Roe v. Wade</em>, Democratic lawmakers and advocates in Oregon, a major hub for abortion rights and LGBTQ+ activism, <a href="https://www.kgw.com/article/news/local/the-story/oregon-hb-2002-abortion-gender-affirming-care-bill-walkout/283-35498207-efda-4657-96ec-c956487ae902">put forth a bill</a> that would make it easier for minors under 15 to obtain an abortion and require insurance companies to cover gender-affirming treatments. The <a href="https://olis.oregonlegislature.gov/liz/2023R1/Downloads/MeasureDocument/HB2002/B-Engrossed">proposed bill</a> would prevent the state from participating in interstate investigations into reproductive and gender-affirming health care and forbid state medical boards from suspending physicians’ licenses if they have been disciplined for providing reproductive or gender-affirming care in states where care is banned.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JYxzHX">
Cassandra Purdy, political director at Planned Parenthood Advocates Oregon, said the bill came out of a recognition that the same movements and same states banning abortion are also attacking access to gender-affirming care and that many health care centers and clinicians provide both services.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hQyxFH">
“We really see this as absolutely necessary to do together,” she said. “One, because our whole movement suffers when one group is harmed, but also because this is a very intentional move to attack both these things.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dnriMS">
The state House passed the bill, but Republican state senators, who argue the measure infringes on parental rights, boycotted.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8FuTpA">
Blair Stenvick, communications manager at LGBTQ+ rights advocacy group Basic Rights Oregon, said Republicans in the state are “emboldened” both by the overturn of <em>Roe v. Wade</em> and the success of Republicans in other states in restricting gender-affirming care for youth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YjX6pE">
“I think any bill we tried to pass around these issues, no matter how strong or minor it was, they would have demonized it and made this fuss over it,” Stenvick said. “There are definitely a lot of issues that they are stalling, but I think our bill is the one that they are targeting the most.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KM8BrH">
The walkout, <a href="https://www.kgw.com/article/news/verify/yes-longest-legislative-walkout-oregon-history/283-0ecaf331-92e1-4ad4-bc6d-98c7d18244d7">currently the longest in Oregon’s history</a>, shows no signs of abating. The state’s legislative session is constitutionally mandated to end June 25.
</p>
<h3 id="h-red-state-law-also-combines-abortion-gender-affirming-care">
Red state law also combines abortion, gender-affirming care
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zbV8gR">
Many red states with abortion bans already on their books when <em>Roe</em> fell then turned to passing bans on gender-affirming care in 2023 legislative sessions. But Nebraska, by combining both issues into one bill, provides a new kind of example of how states can apply arguments against abortion rights into other policy areas, said Alison Gash, professor of political science at the University of Oregon.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qkJHxr">
After a six-week abortion ban failed to pass, Republicans added a 12-week ban into a measure restricting gender-affirming care for trans youth. The ACLU and other groups <a href="https://19thnews.org/2023/05/nebraska-aclu-lawsuit-abortion-transgender-care/">are suing to block the law</a>, arguing that the state legislature used “unprecedented” tactics to pass an abortion ban and that combining two unrelated issues violates the state constitution. Republican lawmakers in Nebraska <a href="https://governor.nebraska.gov/press/governor-pillen-signs-lb574-law-abortion-ban-takes-effect-immediately">argue</a> that restricting abortion and gender-affirming care are linked and that by restricting both, they are “protecting children.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cr7h2Y">
Nebraska is the first state to take such an action, Casey said. “That was a tactical move made by the bill’s proponents to try to get the bill to pass,” he added.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WUb5Wa">
Blumenthal of Connecticut said the aggressive anti-abortion and anti-trans legislation in Republican-controlled states raised the urgency for blue state lawmakers.
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“I think states should not be afraid to act forcefully and quickly to defend their residents,” he said. “We faced initial resistance and hesitation from people who thought that maybe we don’t need to move too far too fast. But ultimately, we’ve been proven right over and over again.”
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<li><strong>Aileen Cannon, the Trump judge assigned to oversee his trial, explained</strong> -
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Trump appointee Judge Aileen Cannon. | United States District Court for the Southern District of Florida
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If Cannon remains the judge on this case, it is unlikely that special counsel Jack Smith will convict Trump — no matter how strong the evidence may be.
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Not long after special counsel Jack Smith filed a <a href="https://www.vox.com/2023/6/9/23755679/indictment-unsealed-trump-charges-explained-classified-documents">damning indictment against former</a> <a href="https://www.vox.com/donald-trump">President Donald Trump</a> — accusing Trump of deliberately withholding classified federal documents that he had no right to possess in the first place — Smith received what could be the worst possible news about his chances of securing a conviction.
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The case is <a href="https://www.nytimes.com/2023/06/10/us/politics/judge-aileen-cannon-trump-documents.html">assigned to Judge Aileen Cannon</a>, a Trump appointee to the federal district court in southern Florida. Cannon, a fairly young judge who was <a href="https://www.senate.gov/legislative/LIS/roll_call_votes/vote1162/vote_116_2_00228.htm">confirmed to the bench after Trump lost reelection</a> but before <a href="https://www.vox.com/joe-biden">President Joe Biden</a> took office, has come onto the national stage so far only once: for her <a href="https://www.vox.com/policy-and-politics/2022/9/22/23366712/donald-trump-special-master-aileen-cannon-11th-circuit-supreme-court-mar-a-lago-classified">extraordinary efforts to sabotage the Justice Department’s investigation</a> into Trump’s possession of classified documents.
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A panel of three appellate judges, two also appointed by Trump, eventually <a href="https://s3.documentcloud.org/documents/22671411/11th-circuit-says-doj-can-resume-criminal-probe-into-trumps-mar-a-lago.pdf">stepped in and neutralized this sabotage</a> — in an opinion that <a href="https://www.vox.com/policy-and-politics/2022/9/22/23366712/donald-trump-special-master-aileen-cannon-11th-circuit-supreme-court-mar-a-lago-classified">identified about a dozen errors in her decisions</a>. Eventually, a second panel of the United States Court of Appeals for the 11th Circuit ruled that <a href="https://fingfx.thomsonreuters.com/gfx/legaldocs/znvnbeggmvl/trump-ca11-2022-12-01.pdf">she never had jurisdiction to interfere with the DOJ’s investigation in the first place</a>.
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That latter opinion — which was handed down by a panel that included two Trump appointees and Chief Judge William Pryor, a <a href="https://www.vox.com/policy-and-politics/23457938/supreme-court-federalist-society-whine-first-amendment">prominent figure in the conservative Federalist Society</a> — labeled Cannon’s decisions favoring Trump “a <a href="https://fingfx.thomsonreuters.com/gfx/legaldocs/znvnbeggmvl/trump-ca11-2022-12-01.pdf">radical reordering of our caselaw</a> limiting the federal courts’ involvement in criminal investigations” and warned that Cannon’s approach “would violate bedrock separation-of-powers limitations.”
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There’s no guarantee that Cannon takes the same cavalierly partisan approach to Trump’s criminal trial as she did to the FBI’s investigation. But it’s enough of a concern that her assignment to the trial, which <a href="https://www.nytimes.com/2023/06/10/us/politics/judge-aileen-cannon-trump-documents.html">her court says was made randomly</a> using the ordinary process where judges are assigned to preside over criminal trials, <a href="https://www.salon.com/2023/06/12/experts-sound-alarm-over-biased-aileen-cannon-amid-ploy-to-block-damning-evidence/">immediately</a> <a href="https://slate.com/news-and-politics/2023/06/aileen-cannon-federal-prosecution-donald-trump.html">sparked</a> alarm <a href="https://twitter.com/glennkirschner2/status/1668048473554313217">among</a> a <a href="https://twitter.com/mrbromwich/status/1667664614564167682">wide range</a> of ideologically diverse lawyers.
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Consider, for example, a warning offered by Orin Kerr, a center-right law professor at University of California Berkeley and one of the nation’s preeminent experts on Fourth Amendment law, who said Friday that Cannon’s past behavior suggests she may do “whatever she can to protect Trump.”
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The Trump indictment allegations are bananas. With that said, if Judge Cannon is presiding, I’m not sure how much the facts will matter. Based on her decisions in the litigation over the warrant, Cannon may do whatever she can to protect Trump. And there’s a lot she can do.
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— Orin Kerr (<span class="citation" data-cites="OrinKerr">@OrinKerr</span>) <a href="https://twitter.com/OrinKerr/status/1667287824062722049?ref_src=twsrc%5Etfw">June 9, 2023</a>
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And make no mistake, if Cannon wants to, she could most likely place such a huge thumb on the scales of justice that it will be impossible for Smith to convince a jury to convict Trump no matter how strong his case may be. As <a href="https://slate.com/news-and-politics/2023/06/aileen-cannon-federal-prosecution-donald-trump.html">Slate’s Mark Joseph Stern writes</a>:
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Cannon can try to rig voir dire [the jury selection process] to help the defense stack the jury with Trump supporters. She can exclude evidence and testimony that’s especially damning to Trump. She can disqualify witnesses who are favorable to the prosecution. She can sustain the defense’s frivolous objections and overrule the prosecution’s meritorious ones. She can direct a verdict of acquittal to render the jury superfluous. She can declare a mistrial prematurely for any number of reasons, including lengthy juror deliberations, and stretch out various deadlines to run out the clock.
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All of this said, there is some case law suggesting that, in truly outlandish cases, the 11th Circuit may step in and replace a trial judge. In one 2006 case, for example, that appeals court removed a judge who <a href="https://casetext.com/case/us-v-martin-284">twice botched the sentencing phase of a criminal trial</a>. As the court wrote, “in light of the two reversals in this case and three other appeals in which we have reversed the same judge for extraordinary downward departures that were without a valid basis in the record,” replacing the judge was warranted. But judges are typically very reluctant to order one of their colleagues off of a case, and the legal standard governing involuntary disqualification of a judge is quite high.
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So Cannon is likely to stay where she is. Here’s what that means for Trump’s potential trial.
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<h3 id="DphRpE">
Cannon’s previous rulings in Trump’s favor suggest that she is in the tank for the former president
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Before we dive into the details of why Cannon may be unfit to hear Trump’s case, it’s important to note two factors that do not justify her removal. She is both a Republican and a Trump appointee, but these factors alone do not mandate recusal. And, indeed, there is a long history of federal judges <a href="https://supreme.justia.com/cases/federal/us/520/681/">ruling against the presidents who appointed them</a>, including in cases that <a href="https://www.law.cornell.edu/supremecourt/text/418/683">directly endangered the president himself</a>.
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So the fact that Cannon owes her job to Trump is not enough to stop her from presiding over his trial. In order to remove a judge, the 11th Circuit concluded in <a href="https://casetext.com/case/us-v-torkington"><em>United States v. Torkington</em></a> (1989), an appeals court must ask if the judge’s behavior on the bench suggests that they “would have difficulty putting [their] previous views and findings aside.” And even in such a case, the 11th Circuit is often reluctant to remove a judge.
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That said, Cannon’s previous conduct in Trump’s case was egregious, and the 11th Circuit twice concluded that she committed multiple legal errors.
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Cannon first got involved in this case after the FBI executed a search warrant in August 2022 at Mar-a-Lago, Trump’s Florida residence, and recovered <a href="https://www.vox.com/policy-and-politics/2022/9/15/23355813/trump-judge-aileen-cannon-special-master-order-justice-department">more than 100 documents with classified markings</a> — including one document that, according to the Washington Post, described “a foreign government’s military defenses, <a href="https://www.washingtonpost.com/national-security/2022/09/06/trump-nuclear-documents/">including its nuclear capabilities</a>.”
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Trump sued, claiming that this investigation must be put on pause, and asking Cannon to appoint a “special master,” a court-appointed official who is sometimes tasked with conducting complicated factual inquiries for the court. Trump wanted the special master to comb through the documents seized by the FBI to determine which of the seized documents should be returned to Trump.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2Xs5Ii">
Cannon agreed to appoint such a special master. More significantly, she also prohibited the Justice Department “<a href="https://www.vox.com/policy-and-politics/2022/9/6/23339017/trump-fbi-mar-a-lago-aileen-cannon-judge-special-master-supreme-court-executive-privilege">from further review and use of any of the materials seized from Plaintiff’s residence</a> … for criminal investigative purposes” until the special master completed his review. That decision didn’t simply put this criminal investigation of Trump on ice, it also <a href="https://www.vox.com/policy-and-politics/2022/9/8/23343477/trump-mar-a-lago-fbi-documents-national-security-fbi-justice-department-doj">sabotaged a parallel intelligence investigation</a> that the FBI conducted to determine if and how Trump’s retention of these classified documents harmed <a href="https://www.vox.com/defense-and-security">national security</a>.
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Eventually, the Justice Department brought the case to the 11th Circuit, which unanimously allowed the FBI to continue its investigations into the classified documents while the special master reviewed the remaining seized materials.
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Of course, the Constitution’s <a href="https://www.law.cornell.edu/constitution/fourth_amendment">Fourth Amendment</a> does protect criminal defendants such as Trump from unreasonable searches of their property. No search warrants may be issued unless law enforcement can <a href="https://www.vox.com/policy-and-politics/2022/9/15/23355813/trump-judge-aileen-cannon-special-master-order-justice-department">show that they have “probable cause” to justify a search</a>, meaning that they have good reason to believe their search will uncover evidence of a crime. Law enforcement must present a sworn statement to a neutral magistrate which explains why they believe they have probable cause, and this magistrate must sign off on the warrant before a criminal suspect’s residence may be searched. The FBI complied with all of these obligations in Trump’s case.
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Outside of these obligations, however, the 11th Circuit’s precedents rarely permit a court to interfere with an ongoing criminal investigation, and then only when the government has “<a href="https://s3.documentcloud.org/documents/22671411/11th-circuit-says-doj-can-resume-criminal-probe-into-trumps-mar-a-lago.pdf">displayed a callous disregard</a>” for a suspect’s constitutional rights. Yet Cannon conceded in one of her rulings that “<a href="https://fingfx.thomsonreuters.com/gfx/legaldocs/znvnbeggmvl/trump-ca11-2022-12-01.pdf">there has not been a compelling showing of callous disregard for [Trump’s] constitutional rights</a>.” But she ordered the DOJ to halt its investigation into Trump anyway.
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That alone, according to the 11th Circuit, “is <a href="https://s3.documentcloud.org/documents/22671411/11th-circuit-says-doj-can-resume-criminal-probe-into-trumps-mar-a-lago.pdf">reason enough to conclude that the district court abused its discretion</a> in exercising equitable jurisdiction here.”
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The 11th Circuit pointed to <a href="https://www.vox.com/policy-and-politics/2022/9/22/23366712/donald-trump-special-master-aileen-cannon-11th-circuit-supreme-court-mar-a-lago-classified">so many additional errors in Cannon’s decisions favoring Trump</a> that it would be tedious to list them here. But there is one more problem in Cannon’s decisions worth highlighting. A major thrust of her decisions is that Trump was <a href="https://www.vox.com/policy-and-politics/2022/9/6/23339017/trump-fbi-mar-a-lago-aileen-cannon-judge-special-master-supreme-court-executive-privilege">entitled to more protection than any other criminal suspect</a> because he is a former president. This status, she claimed, placed “the stigma associated with” the FBI’s seizure of some of his property “in a league of its own.”
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The 11th Circuit had no patience for this argument, holding in a <a href="https://fingfx.thomsonreuters.com/gfx/legaldocs/znvnbeggmvl/trump-ca11-2022-12-01.pdf">December 2022 order</a> that Cannon never had jurisdiction to hear Trump’s challenge to the search warrant, that the same law applies “no matter who the government is investigating.” This principle, according to the appeals court, flows from a 1794 <a href="https://www.vox.com/scotus">Supreme Court</a> decision holding that “our law applies ‘<a href="https://fingfx.thomsonreuters.com/gfx/legaldocs/znvnbeggmvl/trump-ca11-2022-12-01.pdf">to all, without regard to numbers, wealth, or rank</a>.’”
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If another judge had committed similar errors, then perhaps those errors could be attributed to inexperience. Cannon is fairly young — she was still in her late 30s when Trump appointed her in late 2020 — and she’d been a judge for less than two years when she handed down her decisions favoring Trump.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MusnyO">
But whatever else can be said about Cannon, she was hardly unfamiliar with Fourth Amendment principles governing search warrants when she departed so grievously from them. Cannon <a href="https://www.axios.com/2023/06/09/trump-indictment-aileen-cannon-us-district-judge">spent seven years as a federal prosecutor before becoming a judge</a>, a job that would have required her to develop an intimate familiarity with the rules governing search warrants and seizures by law enforcement.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ifZe6U">
And yet, despite spending years developing expertise in this area of law, she still botched the <em>Trump</em> case so badly that two conservative panels of the 11th Circuit deemed her work unacceptable. That suggests that her errors may have been intentional, and not merely the product of ignorance.
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<h3 id="ShLXkU">
How much power does Cannon have to protect Trump?
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In the likely event that Cannon does not recuse herself from this case, and is not ordered to remove herself by a higher Court, she will have significant power to shape how fast this case proceeds, what evidence is presented to the jury, and who sits on that jury. These rulings often involve subtle decisions that are difficult to challenge on appeal, and that may not even have much impact on the case individually — even if the collective impact of a long series of decisions against the prosecution could destroy their case.
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And even if Smith’s legal team does eventually convince an appeals court to reverse any of Cannon’s decisions, appellate courts are normally <a href="https://slate.com/news-and-politics/2023/06/aileen-cannon-federal-prosecution-donald-trump.html">reluctant to hear “interlocutory” appeals</a> — challenges to a trial judge’s decision that are heard before that judge is finished with the case. Many of Cannon’s errors could not even be reviewed until after Trump’s trial is over.
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To give a sense of just how much Cannon could skew this trial in Trump’s favor if she wanted to, consider how jurors are screened in federal court.
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Before any jurors are seated, they will be questioned by counsel on both sides of the case, and potentially by the judge, in a process known as “<a href="https://www.law.cornell.edu/wex/voir_dire">voir dire</a>.” One of the most important purposes of this process is to screen out jurors who may be biased or otherwise unable to evaluate the allegations against a defendant impartially.
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As a general rule, a potential juror might be removed from a jury pool for two reasons. Both the prosecution and the defense have a <a href="https://www.vox.com/22648651/arizona-jury-race-batson-kentucky-peremptory-strikes-challenges-thurgood-marshall">limited number of “peremptory” strikes</a>, which can be used to remove a juror for virtually any reason. Additionally, if a juror’s statements during voir dire suggest that they may not be impartial, either side’s lawyers may ask the judge to remove a juror “for cause.”
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In a normal case, for example, the defense might ask for a juror to be removed for cause if the <s>j</s>uror demonstrates prejudice toward people who share the defendant’s racial or religious background. The prosecution might ask for a juror to be removed for cause if that juror testifies that they’ve had so many negative interactions with the police that they are inclined not to trust any testimony by a police officer.
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But the Trump prosecution is obviously not a normal case, and the judge presiding over it will need to make delicate decisions about which potential jurors can be impartial about one of the most famous and polarizing individuals on the planet. Suppose that a potential juror testifies that they voted for Trump twice and once attended a Trump rally, but that they believe they can still be impartial. Should this juror be removed for cause? What about a Biden voter who donated to the incumbent president’s campaign? Or a juror who testifies that they are a regular <a href="https://www.vox.com/media">Fox News</a> fan? Or a juror who marched in a protest against Trump’s immigration <a href="https://www.vox.com/policy">policies</a>?
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Trial judges normally have a great deal of discretion to decide which jurors may be included and which jurors must be excluded. So, if Cannon presides, there’s a real risk that she might try to stack the jury with sympathetic jurors. Smith’s legal team could still use their peremptory strikes to remove MAGA jurors, but they will have a limited number of those strikes.
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And Cannon would not even need to stack the entire jury to sabotage Smith’s case against Trump, if she was so inclined. The Supreme Court held in <a href="https://www.supremecourt.gov/opinions/19pdf/18-5924_n6io.pdf"><em>Ramos v. Louisiana</em></a> (2020) that the Constitution “requires a unanimous verdict to convict a defendant of a serious offense.” So Cannon would only need to seat one MAGA juror to ensure that, at the very least, even the strongest possible case against Trump will end in a hung jury and a mistrial.
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Voir dire, moreover, is just one small part of a trial. During the rest of the trial, the presiding judge will rule on which evidence can be introduced and which evidence must be excluded, what questions lawyers may ask witnesses and which questions are forbidden, and which witnesses are even allowed to testify.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uYhA1x">
And, even if Trump is convicted despite potentially biased rulings from Cannon, she will have the first crack at sentencing Trump — and the Supreme Court held in <a href="https://supreme.justia.com/cases/federal/us/552/38/"><em>Gall v. United States</em></a> (2007) that appeals courts must review a trial judge’s sentencing decisions “under a deferential abuse-of-discretion standard.” That means any lawyer challenging a trial judge’s sentencing decision faces a difficult battle.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s58hdU">
All of this should come with the caveat that, perhaps, Cannon learned her lesson after she was smacked down twice by an appeals court, and maybe she will be more careful about adhering to the law during Trump’s trial. But her conduct in the litigation over the Mar-a-Lago search warrant should not fill anyone with hope that she will suddenly decide to be unbiased and impartial.
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<h3 id="qLqlF1">
Can Cannon be removed from this case?
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wAiOt3">
There is a chance that Cannon could be removed from the case if Smith seeks to disqualify her, or if the 11th Circuit decides on its own to remove her on appeal. As that court said in the <em>Torkington</em> case, such disqualification “is appropriate where the trial judge has engaged in conduct that <a href="https://casetext.com/case/us-v-torkington#p1447">gives rise to the appearance of impropriety or a lack of impartiality</a> in the mind of a reasonable member of the public.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wx8wTc">
That said, the 11th Circuit has typically required a judge to repeatedly engage in behavior that casts doubt on their impartiality before removing that judge. In <em>Torkington</em>, for example, the trial judge “stated at various times that he felt the taxpayer had little interest in this type of suit, that this prosecution was ‘silly,’ and that it was a waste of the taxpayers’ money.” He also suggested that the prosecution might arise from a <a href="https://casetext.com/case/us-v-torkington#p1447">“vendetta” against the defendant</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xrWJRR">
Similarly, in <a href="https://casetext.com/case/us-v-martin-284"><em>United States v. Martin</em></a> (2006), another case where the 11th Circuit disqualified a trial judge from continuing to hear a criminal case, the appeals court did so only after it had twice reversed the trial judge’s sentencing decisions — and only after the same judge had been reversed in three other cases for handing down lenient sentences that the appeals court deemed “extraordinary.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w6UPNS">
There is no doubt Smith’s team could write a well-reasoned brief, relying on cases like <em>Torkington</em> and <em>Martin,</em> that would make a strong case for disqualifying Cannon. And if the right 11th Circuit panel is assigned to hear a request to remove Cannon, that panel might agree she must be recused.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3fFnTK">
But the 11th Circuit is also a conservative court — seven of its 12 active judges were appointed by Republicans and six were appointed by Trump. And the standard for disqualifying a judge is very high. Realistically, it is difficult to know how the appeals court would rule on a request to disqualify Cannon. A competent judge could write a decision supporting either outcome.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GGGEZy">
All of this said, I would hope that any judge asked to review whether Cannon should preside over this case would pay particular attention to one line in <em>Torkington</em>, where the court said that removing a trial judge from a case is sometimes necessary because “<a href="https://casetext.com/case/us-v-torkington#p1447">the judicial system has the obligation of preserving public confidence in the impartial and fair administration of justice</a>.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="go9ff8">
The trial of Donald Trump, a longtime celebrity and former president, is likely to be one of the most closely watched legal proceedings in American history. Every decision the trial judge makes will be scrutinized by a small army of attorneys, many of whom will be nationally prominent experts such as Kerr. Numerous media outlets (including the one you are reading right now) also employ lawyers with considerable expertise in federal courts, who will shine a light on every error committed by the judge in Trump’s case.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CLDpSj">
The 11th Circuit, in other words, needs to ask itself whether it can trust Aileen Cannon to speak for the federal judiciary in one of the most closely watched tests of its legitimacy that the third branch of government will ever face.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rohit Sharma likely to lead in Caribbean but not certain to remain Test captain after Windies tour</strong> - Rohit Sharma will lead Indian in the two-Test series in the West Indies and then perhaps sit with BCCI and decide on his future in traditional format.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Daily Quiz | On NBA champions</strong> - With the Denver Nuggets and Miami Heat slugging it out for the NBA title (the Nuggets led 3-1 as this quiz went to press), here’s a quiz on NBA champions</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Part-time Uber driver Berry Henson travels world to get to U.S. Open</strong> - Henson — he goes by his college nickname “Hensonator” — figures the way he has battled long odds just to get here should serve him well</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indonesia Open badminton championship | Sindhu, Prannoy make prequarters; Treesa-Gayatri bow out</strong> - Sindhu now faces an even tougher battle as she is next up against third seed Tai Tzu Ying.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>G.S Randhawa steps down as AFI selection panel chairman</strong> - The former Asian Games champion cited old age as his reason to step down from the post</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Admission process for degree colleges in Andhra Pradesh to start from June 19</strong> - Special category verification will be done from June 21 to 23 and students can exercise web options from June 26 to 30, says APSCHE Secretary Y. Nazeer Ahammed</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Monson case comes back to haunt Opposition and ruling front</strong> - The two-year-old case, pretty much erased from the public domain, burst onto cable news chyrons and across social media after the Crime Branch named Kerala Pradesh Congress Committee (KPCC) president K. Sudhakaran, MP, and two ranking police officers as suspects in the alleged fraud.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Here are the big stories from Karnataka today</strong> - Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by Nalme Nachiyar.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Four farmers handcuffed while being taking to court</strong> - The farmers had been protesting against government move to acquire their lands for the proposed Regional Ring Road</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>You cannot hide behind advisories: K.C. Venugopal slams Aviation Minister Jyotiraditya Scindia over high airfares</strong> - Mr. Venugopal said in a tweet that this entire “flight price fiasco” is unravelling the “criminal extent” to which the Ministry of Civil Aviation “neglected” passenger welfare and the aviation sector</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>French HR murders: Man on trial for killing three female job managers</strong> - The suspect is accused of targeting HR managers he held responsible for wrecking his career.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Silvio Berlusconi’s big footprint in Europe</strong> - The three-time prime minister leaves an indelible stamp on his country and on the European continent as a whole.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Channel migrants: More than 600 people cross in one day</strong> - The Home Office says 616 people crossed the Channel on Sunday - the highest daily number this year.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>France shooting suspect under investigation for murder</strong> - Eleven-year-old Solaine Thornton was shot dead while playing on a swing in her garden on Saturday.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tenant urges others to follow after deposit win</strong> - A tribunal rules Adéla Koubová should get her deposit back because her Edinburgh flat was not a holiday let.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>API pricing protests caused Reddit to crash for 3 hours</strong> - Thousands of subreddits going dark broke Reddit’s website, mobile app. - <a href="https://arstechnica.com/?p=1947293">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nature bans AI-generated art from its 153-year-old science journal</strong> - “The process of publishing … is underpinned by a shared commitment to integrity.” - <a href="https://arstechnica.com/?p=1947220">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“Clearly predatory”: Western Digital sparks panic, anger for age-shaming HDDs</strong> - Drives automatically get a “warning” flag if powered on for 3 years. - <a href="https://arstechnica.com/?p=1947132">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google’s ad tech dominance spurs more antitrust charges, report says</strong> - Google’s ad revenue amounted to nearly $225 billion in 2022. - <a href="https://arstechnica.com/?p=1947247">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FTC files to block Microsoft’s $69B Activision Blizzard acquisition [Updated]</strong> - The injunction could disrupt the deal as its mid-July deadline approaches. - <a href="https://arstechnica.com/?p=1947211">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reddit is killing third-party applications (and itself). Read more in the comments.</strong> - submitted by <a href="https://www.reddit.com/user/JokeSentinel"> /u/JokeSentinel </a> <br/> <span><a href="https://i.redd.it/jzi76q55il5b1.png">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/147p78o/reddit_is_killing_thirdparty_applications_and/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>When you go to church in the morning you say, “Amen.”</strong> - <!-- SC_OFF --></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
When you go to church in the afternoon you say, “Pmen.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/vedicsun"> /u/vedicsun </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/146sgvx/when_you_go_to_church_in_the_morning_you_say_amen/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/146sgvx/when_you_go_to_church_in_the_morning_you_say_amen/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Did you hear about Apple’s new VR headset?</strong> - <!-- SC_OFF --></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
They’re called the iGlasses
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/sheeeeeez"> /u/sheeeeeez </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/1470v9z/did_you_hear_about_apples_new_vr_headset/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/1470v9z/did_you_hear_about_apples_new_vr_headset/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Doctors say 3 out of 5 people suffer from chronic diarrhea.</strong> - <!-- SC_OFF --></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
2 out of 5 are sick fucks and enjoy it..
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Response-Cheap"> /u/Response-Cheap </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/146ezun/doctors_say_3_out_of_5_people_suffer_from_chronic/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/146ezun/doctors_say_3_out_of_5_people_suffer_from_chronic/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>If women want a guy who is taller than them…</strong> - <!-- SC_OFF --></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
why do they care if he has hair on top of his head?
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/2Agile2Furious"> /u/2Agile2Furious </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/146hxfi/if_women_want_a_guy_who_is_taller_than_them/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/146hxfi/if_women_want_a_guy_who_is_taller_than_them/">[comments]</a></span></p></li>
</ul>
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