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+ + + ++Background: With a rapidly changing evidence base, high-quality clinical management guidelines (CMGs) are key tools for aiding clinical decision making and increasing access to best available evidence-based care. A rapid review of COVID-19 CMGs found that most lacked methodological rigour, overlooked many at-risk populations, and had variations in treatment recommendations. Furthermore, social science literature highlights the complexity of implementing guidelines in local contexts where they were not developed and the resulting potential to compound health inequities. The aim of this study was to evaluate access to, inclusivity of, and implementation of Covid-19 CMGs in different settings. Methods: A cross-sectional survey of clinicians worldwide from 15 June to 20 July 2020, to explore access to and implementation of Covid-19 CMGs and treatment and supportive care recommendations provided. Data on accessibility, inclusivity, and implementation of CMGs. were analyzed by geographic location. Results: Seventy-six clinicians, from 27 countries responded, 82% from high-income countries, 17% from low-middle income countries. Most respondents reported access to Covid-19 CMG and confidence in implementation of these. However, many respondents, particularly from LMICs reported barriers to implementation, including limited access to treatments and equipment. Only 20% of respondents reported having access to CMGs covering care for children, 25% for pregnant women and 50% for older adults (>65 years). Themes emerging were for CMGs to include recommendations for different at-risk populations, and settings, include supportive care guidance, be readily updated as evidence emerges, and CMG implementation supported by training, and access to treatments recommended. Conclusion: Our findings highlight important gaps in Covid-19 CMG development and implementation challenges during a pandemic, particularly affecting different at-risk populations and lower resourced settings. The findings highlight a need for a new, harmonized evidence-based, that is inclusive and adaptable for different context, incorporating implementation support, to improve access in evidence-based care recommendations during an emergency. +
++Background: Patients with end-stage kidney disease receiving in-center hemodialysis are at high risk of exposed to, and dying from, SARS-CoV-2. As impairments in both humoral and cellular immunity are common in this population, their response to vaccination against SARS-CoV-2 is uncertain. Methods: We have followed in-center hemodialysis patients in the Réseau Rénal Québécois since March 2020 with serial PCRs for COVID-19 and clinical outcomes. Plasma samples were taken from 58 patients from one center before, and 4 weeks after, vaccination with one dose of the BNT162b2 mRNA vaccine. Anti-RBD (region binding domain of the SARS-CoV-2 Spike protein) IgG levels were measured using ELISA and compared to levels in 32 health care worker (HCW) controls, as well as levels in convalescent plasma taken from 12 hemodialysis patients 4-12 weeks after COVID-19 infection. Patients were stratified based on evidence of previous infection with COVID-19 (positive PCR or antiRBD detectable at baseline). Results: Compared with health-care workers, hemodialysis patients without prior COVID-19 exhibited significantly lower anti-RBD IgG levels 4 weeks after vaccination (p=0.0007). Anti-RBD IgG was non-detectable in 1/16 (6%) of HCWs, and 25/46 (54%) of dialysis patients (p=0.0008). In dialysis patients previously infected with COVID-19, mean anti-RBD levels were significantly lower than their HCW controls (p=0.0031), but not signficantly different than those in convalescent plasma of recently infected dialysis patients (p=NS). No patients reported any symptoms 7 days after vaccination on a standardized questionnaire. Conclusion: The BNT162b2 vaccine was well-tolerated in hemodialysis patients, but failed to elicit a humoral immune response in >50% patients by 4 weeks. Whether these patients develop antibodies or T-cell responses after prolonged observation requires further study. Until then, we recommend that rigorous infection prevention and control measures in the dialysis unit and outside of it be continued to prevent SARS-CoV-2 infection in this susceptible population. +
++A challenge to controlling the SARS-CoV-2 pandemic is the ability of the virus to adapt to its new human hosts, with novel and more transmissible strains of the virus being continually identified. Yet there are no generally accepted methods to consistently estimate the relative magnitude of the change in transmissiblity of newly emerging variants. In this paper we consider three methods for examining and quantifying positive selection of new and emerging strains of SARS-CoV-2 over an existing wild-type strain. We consider replication at the level of countries and allow for the action of other processes that can change variants9 frequencies, specifically migration and drift. We apply these methods to the D614G spike mutation and the variant designated B.1.1.7, in every country where there is sufficient sequence data. For each of D614G and B.1.1.7, we find evidence for strong selection (greater than 25% increased contagiousness) in more than half of countries analyzed. Our results also shows that the selective advantages of these strains are highly heterogeneous at the country level, suggesting the need for a truly global perspective on the molecular epidemiology of SARS-CoV-2. +
++Background. Effective simple, home-treatment algorithms implemented on the basis of a pathophysiologic and pharmacologic rationale to accelerate recovery and prevent hospitalization of patients with early coronavirus disease 2019 (COVID-19) would have major implications for patients and health care providers. Methods. This academic, matched-cohort study compared outcomes of 90 consecutive consenting patients with mild COVID-19 treated at home by their family physicians from October 2020 to January 2021 according to the proposed recommendation algorithm with those of 90 age-, sex-, and comorbidities- matched patients who received other therapeutic regimens. Primary outcome was time to resolution of major symptoms. Secondary outcomes included prevention of hospitalization. Analyses were by intention-to-treat. Findings. All patients achieved complete remission. The median [IQR] time to resolution of major symptoms was 18 [14-23] days in the recommended schedule cohort and 14 [7-30] days in the matched control cohort (p=0.033). Minor symptoms persisted in a lower percentage of patients in the recommended than in the control cohort (23.3% versus 73.3%, respectively, p<0.0001) and for a shorter period (p=0.0107). Two patients in the recommended cohort were hospitalized compared to 13 (14.4%) controls (Log-rank test, p=0.0038). Prevention algorithm abated the days and cumulative costs of hospitalization by >90% (from 481 to 44 days and from 296 to 28 thousand Euros, respectively. 1.2 patients had to be treated to save one hospitalization event. Interpretation. Implementation of an early, home-treatment algorithm failed to accelerate recovery from major symptoms of COVID-19, but almost blunted the risk of hospitalization and related treatment costs. +
++Background: The test-trace-isolate-quarantine (TTIQ) strategy is used to break chains of transmission during a disease outbreak and is one of the key pillars of the non-pharmaceutical interventions to suppress the ongoing SARS-CoV-2 pandemic. Here we quantify how the probability of detecting and isolating a case, the fraction of contacts identified and quarantined, and the delays that are inherent to these processes impact the reduction of disease transmission by TTIQ. Methods: We develop an analytical model of disease transmission that is based on empirical distributions of the timing of SARS-CoV-2 transmission. The isolation of confirmed cases and quarantine of their contacts is implemented by truncating their respective infectious periods. Using this model we quantify how the parameters describing the coverage of the TTIQ intervention and the inherent delays impact the level of disease transmission. We provide an online application to assess the efficacy of TTIQ as a function of these parameters. Findings: Increasing the coverage of testing and isolating index cases has the largest effect on transmission reduction, followed by reducing the delay between symptom onset and index case isolation. The impacts of these two changes are substantially greater than the effect of increasing the fraction of contacts which are traced and subsequently quarantined or reducing the delay to quarantine. We find that, on average, increasing testing and isolation coverage and reducing the delay to isolation have four-fold and three-fold greater impacts, respectively, on transmission reduction compared to increasing contact tracing coverage. Increasing the duration of lookback in which contacts are identifiable has limited impact on TTIQ efficacy. Interpretation: To be a successful intervention strategy, TTIQ requires intensive testing. The majority of transmission is prevented by isolating symptomatic individuals, and doing so in a short amount of time. Despite the lesser impact, adding contact tracing and quarantine to testing and isolation increases the parameter space in which an epidemic is controllable, and is necessary to control epidemics with a high reproductive number. Our results show how TTIQ can be improved and optimised. +
++Identification of host genetic factors that predispose individuals to severe COVID-19 is important, not only for understanding the disease and guiding the development of treatments, but also for risk prediction when combined to form a polygenic risk score (PRS). Using population controls, Pairo-Castineira et al. identified 12 SNPs (a panel of 8 SNPs and a panel of 6 SNPs, with two SNPs in both panels) associated with severe COVID-19. Using controls with asymptomatic or mild COVID-19, we were able to replicate the association with severe COVID-19 for only three of their SNPs and found marginal evidence for an association for one other. When combined as an 8-SNP PRS and a 6-SNP PRS, we found no evidence of association with severe COVID-19. The difference in our results and the results of Pairo-Castineira et al. might be the choice of controls: population controls vs controls with asymptomatic or mild COVID-19. +
++Objective To study the airflow, transmission and clearance of aerosols in the clinical spaces of a hospital ward that had been used to care for patients with COVID-19, and to examine the impact of portable air cleaners on aerosol clearance. Design Observational study Setting A single ward of a tertiary public hospital in Melbourne Australia Intervention Glycerine-based aerosol was used as a surrogate for respiratory aerosols. The transmission of aerosols from a single patient room into corridors and a nurses station in the ward was measured. The rate of clearance of aerosols was measured over time from the patient room, nurses station and ward corridors with and without air cleaners (also called portable HEPA filters). Results Aerosols rapidly travelled from the single patient room into other parts of the ward. Air cleaners were effective in increasing the clearance of aerosols from the air in clinical spaces and reducing their spread to other areas. Conclusion Air cleaners may be useful in clinical spaces to help reduce the risk of healthcare acquired acquisition of respiratory viruses that are transmitted via aerosols. +
++The recognition and representation of BAME community as 9high risk9 of Covid-19 in the UK presents both a health and an identity threat to this ethnic group. This study employed thematic analysis to explore response to these threats as related by a sample of thirteen middle class members of the South Asian community. This work advances both health and identity psychological theory by recognising the affinity between expressions of health efficacy and identity. Our findings identify South Asian intragroup stigmatisation and commonalities that have implications for the promotion of health behaviour and health communications for minority groups. +
+Pilot Trial of XFBD, a TCM, in Persons With COVID-19 - Condition: Â Covid19
Interventions:  Drug: Xuanfei Baidu Granules;  Other: Placebo
Sponsor:  Darcy Spicer
Recruiting
SERUR: COVID-19 Serological Survey of Staff From the University Reims-Champagne Ardennes - Condition: Â Covid19
Intervention:  Diagnostic Test: Anti-SARS-CoV2 Serology
Sponsor:  Université de Reims Champagne-Ardenne
Completed
Study to Evaluate the Viral Load Reduction of a Single Dose of Plitidepsin in Adult Patients With COVID-19 - Condition: Â COVID-19
Interventions:  Drug: Plitidepsin;  Drug: Symptomatic Treatment
Sponsors:  PharmaMar;  Apices Soluciones S.L.
Not yet recruiting
ANTIcoagulation in Severe COVID-19 Patients - Condition:  Severe COVID-19 Pneumonia
Interventions:  Drug: Tinzaparin, Low dose prophylactic anticoagulation;  Drug: Tinzaparin, High dose prophylactic anticoagulation;  Drug: Tinzaparin,Therapeutic anticoagulation
Sponsor:  Assistance Publique - HÎpitaux de Paris
Not yet recruiting
Neuromodulation in COVID-19 Patients - Condition: Â COVID-19
Interventions:  Device: Transcranial direct-current stimulation;  Device: Sham Transcranial direct-current stimulation
Sponsors:  DâOr Institute for Research and Education;  Rio de Janeiro State Research Supporting Foundation (FAPERJ);  Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico;  Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior.
Not yet recruiting
A Study to Evaluate MVC-COV1901 Vaccine Against COVID-19 in Elderly Adults - Condition: Â Covid19Â Vaccine
Interventions: Â Biological:Â MVC-COV1901Â (High-Dose); Â Biological:Â MVC-COV1901(Mid-Dose)
Sponsor:  Medigen Vaccine Biologics Corp.
Not yet recruiting
Immunogenicity and Safety of Recombinant COVID-19 Vaccine (CHO Cells) - Condition: Â COVID-19
Interventions: Â Biological: a middle-dose recombinant COVID-19 vaccine (CHO Cell) (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose recombinant COVID-19 vaccine (CHO Cell) (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a middle-dose recombinant COVID-19 vaccine (CHO Cell) (60-85 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose recombinant COVID-19 vaccine (CHO Cell) (60-85 years) at the schedule of day 0, 28, 56; Â Biological: a middle-dose placebo (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose placebo (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a middle-dose placebo (60-85 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose placebo (60-85 years) at the schedule of day 0, 28, 56
Sponsors:  Jiangsu Province Centers for Disease Control and Prevention;  Academy of Military Medical SciencesïŒAcademy of Military SciencesïŒPLA ZHONGYIANKE Biotech Co, Ltd. LIAONINGMAOKANGYUAN Biotech Co, Ltd
Recruiting
STOP-COVID19: Superiority Trial Of Protease Inhibition in COVID-19 - Condition: Â Covid19
Interventions: Â Drug:Â Brensocatib; Â Drug:Â Placebo
Sponsors:  University of Dundee;  NHS Tayside;  Insmed Incorporated
Completed
Post COVID-19 Syndrome and the Gut-lung Axis - Condition: Â Covid19
Interventions:  Dietary Supplement: Omni-Biotic Pro Vi 5;  Dietary Supplement: Placebo
Sponsors:  Medical University of Graz;  CBmed Ges.m.b.H.
Not yet recruiting
Respiratory Tele Monitoring COVID 19 (TMR COVID-19) - Condition: Â Covid19
Interventions:  Device: Radius PPG Tetherless Pulse Oximetry (Masimo);  Device: usual monitoring
Sponsor:  Assistance Publique Hopitaux De Marseille
Recruiting
Monitoring of COVID-19 Seroprevalence Among GHdC Staff Members - Condition: Â Covid19
Intervention: Â Diagnostic Test: Serology to determine SARS-CoV-2 infection
Sponsor:  Grand HÎpital de Charleroi
Recruiting
Favipiravir in High-risk COVID-19 Patients - Condition: Â Covid19
Intervention: Â Drug:Â Favipiravir
Sponsor:  Penang Hospital, Malaysia
Recruiting
Efficacy of Psidii Guavaâs Extract For COVID-19 - Condition: Â Covid19
Interventions:  Drug: Extract Psidii guava;  Combination Product: Standard therapy for Covid-19 patient
Sponsor:  Faculty of Medicine Baiturrahmah University
Completed
Essential Amino Acid Supplementation in Older Adult COVID-19 Patients - Condition: Â Covid19
Interventions:  Drug: Essential amino acids;  Dietary Supplement: Maltodextrin
Sponsor:  University of Arkansas
Not yet recruiting
Tele-rehabilitation Program After Hospitalization for COVID-19 - Condition: Â COVID-19Â Pneumonia
Interventions: Â Other:Â TR; Â Other:Â TSu
Sponsors:  Istituti Clinici Scientifici Maugeri SpA;  Istituto Auxologico Italiano
Recruiting
Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by Grazoprevir - Outcomes of various clinical studies for the coronavirus disease 2019 (COVID-19) treatment indicated that the drug acts via inhibition of multiple pathways (targets) is likely to be more successful and promising. Keeping this hypothesis intact, the present study describes for the first-time, Grazoprevir, an FDA approved anti-viral drug primarily approved for Hepatitis C Virus (HCV), mediated multiple pathway control via synergistic inhibition of viral entry targeting host cellâŠ
Activation of STING signaling pathway effectively blocks human coronavirus infection - The COVID-19 pandemic poses a serious global health threat. The rapid global spread of SARS-CoV-2 highlights an urgent need to develop effective therapeutics for blocking SARS-CoV-2 infection and spread. Stimulator of Interferon Genes (STING) is a chief element in host antiviral defense pathways. In this study, we examined the impact of the STING signaling pathway on coronavirus infection using the HCoV-OC43 model. We found that HCoV-OC43 infection did not stimulate the STING signaling pathway,âŠ
Antiviral Drug Ivermectin at Nanomolar Concentrations Inhibits Glycine-Induced Chloride Current in Rat Hippocampal Neurons - Ivermectin (IVM) belongs to the class of macrocyclic lactones, which is used as an antiparasitic agent. At present, the researchers focus on possibility to use IVM in treatment of certain forms of cancer and viral diseases such as COVID-19. The mechanisms of IVM action are not clear. It is assumed that IVM affects chloride channels and increases cytoplasmic concentration of chloride. This study examines the effect of IVM on chloride currents induced by glycine (I(Gly)). Experiments were carriedâŠ
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells - Host-cell cysteine proteases play an essential role in the processing of the viral spike protein of SARS coronaviruses. K777, an irreversible, covalent inactivator of cysteine proteases that has recently completed phase 1 clinical trials, reduced SARS-CoV-2 viral infectivity in several host cells: Vero E6 (EC(50)< 74 nM), HeLa/ACE2 (4 nM), Caco-2 (EC(90) = 4.3 ÎŒM), and A549/ACE2 (<80 nM). Infectivity of Calu-3 cells depended on the cell line assayed. If Calu-3/2B4 was used, EC(50) was 7 nM, butâŠ
Novel Compounds Targeting Neuropilin Receptor 1 with Potential To Interfere with SARS-CoV-2 Virus Entry - Neuropilin-1 (NRP-1) is a multifunctional transmembrane receptor for ligands that affect developmental axonal growth and angiogenesis. In addition to a role in cancer, NRP-1 is a reported entry point for several viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19). The furin cleavage product of SARS-CoV-2 Spike protein takes advantage of the vascular endothelial growth factor A (VEGF-A) binding site on NRP-1âŠ
Multiple Sites on SARS-CoV-2 Spike Protein are Susceptible to Proteolysis by Cathepsins B, K, L, S, and V - SARS-CoV-2 is the coronavirus responsible for the COVID-19 pandemic. Proteases are central to the infection process of SARS-CoV-2. Cleavage of the spike protein on the virusâs capsid causes the conformational change that leads to membrane fusion and viral entry into the target cell. Since inhibition of one protease, even the dominant protease like TMPRSS2, may not be sufficient to block SARS-CoV-2 entry into cells, other proteases that may play an activating role and hydrolyze the spike proteinâŠ
Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors - Transmembrane protease serine-2 (TMPRSS2) is a cell-surface protein expressed by epithelial cells of specific tissues including those in the aerodigestive tract. It helps the entry of novel coronavirus (n-CoV) or Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the host cell. Successful inhibition of the TMPRSS2 can be one of the crucial strategies to stop the SARS-CoV-2 infection. In the present study, a set of bioactive molecules from Morus alba Linn. were screened against theâŠ
New Decade, Old Debate: Blocking the Cytokine Pathways in Infection-Induced Cytokine Cascade - CONCLUSIONS: As ongoing clinical trials determine the efficacy and safety of anticytokine therapy in patients with coronavirus disease 2019, clinicians should uphold caution when incorporating it into treatment protocols, while maintaining focus on established evidence-based practices and the mantra of âless is more.â
An in silico analysis of effective siRNAs against COVID-19 by targeting the leader sequence of SARS-CoV-2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a retrovirus having genome size of around 30 kb. Its genome contains a highly conserved leader sequence at its 5â end, which is added to all subgenomic mRNAs at their 5â terminus by a discontinuous transcription mechanism and regulates their translation. Targeting the leader sequence by RNA interference can be an effective approach to inhibit the viral replication. In the present study an in-silico prediction of highly effectiveâŠ
Drug Repurposing of Itraconazole and Estradiol Benzoate against COVID-19 by Blocking SARS-CoV-2 Spike Protein-Mediated Membrane Fusion - SARS-CoV-2 caused the emerging epidemic of coronavirus disease in 2019 (COVID-19). To date, there are more than 82.9 million confirmed cases worldwide, there is no clinically effective drug against SARS-CoV-2 infection. The conserved properties of the membrane fusion domain of the spike (S) protein across SARS-CoV-2 make it a promising target to develop pan-CoV therapeutics. Herein, two clinically approved drugs, Itraconazole (ITZ) and Estradiol benzoate (EB), are found to inhibit viral entry byâŠ
Sulfoglycodendrimer Therapeutics for HIV-1 and SARS-CoV-2 - Hexavalent sulfoglycodendrimers (SGDs) are synthesized as mimics of host cell heparan sulfate proteoglycans (HSPGs) to inhibit the early stages in viral binding/entry of HIV-1 and SARS-CoV-2. Using an HIV neutralization assay, the most promising of the seven candidates are found to have sub-micromolar anti-HIV activities. Molecular dynamics simulations are separately implemented to investigate how/where the SGDs interacted with both pathogens. The simulations revealed that the SGDs: 1) developâŠ
Recent Advances on Nanomaterials to COVID-19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS-CoV-2 Inhibition/Inactivation - The current pandemic of coronavirus disease 2019 (COVID-19) is recognized as a public health emergency of worldwide concern. Nanomaterials can be effectively used to detect, capture/inactivate or inhibit coronavirus cell entry/replication in the human host cell, preventing infection. Their potential for nanovaccines, immunoengineering, diagnosis, repurposing medication, and disinfectant surfaces targeting the novel coronavirus (SARS-CoV-2) is highlighted. In this systematic review the aim is toâŠ
Effect of coronavirus lockdowns on the ambient seismic noise levels in Gujarat, northwest India - The Covid-19 pandemic created havoc and forced lockdowns in almost all the countries worldwide, to inhibit social spreading. In India as well, as a precautionary measure, complete and partial lockdowns were announced in phases during March 25 to May 31, 2020. The restricted human activities led to a drastic reduction in seismic background noise in the high frequency range of 1-20 Hz, representative of cultural noise. In this study, we analyse the effect of anthropogenic activity on the EarthâŠ
Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged virus that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2 spike protein, like SARS-CoV-1, uses the angiotensin converting enzyme 2 (ACE2) as a cellular receptor to initiate infection. Compounds that interfere with the SARS-CoV-2 spike protein receptor binding domain protein (RBD)-ACE2 receptor interaction may function as entry inhibitors. Here, we used a dual strategy of molecular docking andâŠ
Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with increased disease severity and poor clinical outcomes in diabetic patients compared with their nondiabetic counterparts. Diabetes/hyperglycemia-triggered endothelial dysfunction and hyperactive inflammatory and immune responses are correlated to twofold to threefold higher intensive care hospitalizations and more than twice the mortality among diabetic coronavirus disease 2019 (COVID-19) patients. WhileâŠ
5-(4-TERT-BUTOXY PHENYL)-3-(4N-OCTYLOXYPHENYL)-4,5-DIHYDROISOXAZOLE MOLECULE (C-I): A PROMISING DRUG FOR SARS-COV-2 (TARGET I) AND BLOOD CANCER (TARGET II) - The present invention relates to a method ofmolecular docking of crystalline compound (C-I) with SARS-COV 2 proteins and its repurposing with proteins of blood cancer, comprising the steps of ; employing an algorithmto carry molecular docking calculations of the crystalized compound (C-I); studying the compound computationally to understand the effect of binding groups with the atoms of the amino acids on at least four target proteins of SARS-COV 2; downloading the structure of the proteins; removing water molecules, co enzymes and inhibitors attached to the enzymes; drawing the structure using Chem Sketch software; converting the mol file into a PDB file; using crystalized compound (C-I) for comparative and drug repurposing with two other mutated proteins; docking compound into the groove of the proteins; saving format of docked molecules retrieved; and filtering and docking the best docked results. - link
USING CLINICAL ONTOLOGIES TO BUILD KNOWLEDGE BASED CLINICAL DECISION SUPPORT SYSTEM FOR NOVEL CORONAVIRUS (COVID-19) WITH THE ADOPTION OF TELECONFERENCING FOR THE PRIMARY HEALTH CENTRES/SATELLITE CLINICS OF ROYAL OMAN POLICE IN SULTANATE OF OMAN - - link
Peptides and their use in diagnosis of SARS-CoV-2 infection - - link
A PROCESS FOR SUCCESSFUL MANAGEMENT OF COVID 19 POSITIVE PATIENTS - - link
IN SILICO SCREENING OF ANTIMYCOBACTERIAL NATURAL COMPOUNDS WITH THE POTENTIAL TO DIRECTLY INHIBIT SARS COV 2 - IN SILICO SCREENING OF ANTIMYCOBACTERIAL NATURAL COMPOUNDS WITH THE POTENTIAL TO DIRECTLY INHIBIT SARS COV 2Insilico screening of antimycobacterial natural compounds with the potential to directly inhibit SARS COV2 relates to the composition for treating SARS-COV-2 comprising the composition is about 0.1 â 99% and other pharmaceutically acceptable excipients. The composition also treats treating SARS, Ebola, Hepatitis-B and HepatitisâC comprising the composition is about 0.1 â 99% and other pharmaceutically acceptable excipients. - link
Sars-CoV-2 vaccine antigens - - link
SARS-COV-2 BINDING PROTEINS - - link
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Ein BildschirmgerÀt mit verbesserter Wirkung bei der Befestigung von UV-Entkeimungslampen, umfassend: ein BildschirmgerÀt, das einen Umfang hat; eine UV-Entkeimungslampe, die sich am Umfang des BildschirmgerÀts befindet; eine Stromquelle, die elektrisch mit der UV-Entkeimungslampe verbunden ist; eine Steuerschaltung, die elektrisch mit der UV-Entkeimungslampe verbunden ist; und eine Befestigungsvorrichtung, durch die die UV-Entkeimungslampe am Umfang des BildschirmgerÀts befestigbar ist, wobei die Befestigungsvorrichtung einen Sitzkörper, eine erste Klemmplatte und eine zweite Klemmplatte aufweist, wobei der Sitzkörper mit der UV-Entkeimungslampe versehen ist, wobei die erste Klemmplatte und die zweite Klemmplatte beabstandet am Sitzkörper gleitbar angeordnet sind, wodurch ein Klemmabstand zwischen der ersten Klemmplatte und der zweiten Klemmplatte besteht, wobei ein elastisches Element zwischen der zweiten Klemmplatte und dem Sitzkörper angeordnet ist, um die zweite Klemmplatte dazu zu zwingen, sich der ersten Klemmplatte zu nÀhern.
+
Schublade mit antiepidemischer Wirkung, mit einem Schrank (1); mindestens einer Schublade (2), die in dem Schrank (1) angeordnet ist, wobei jede Schublade (2) einen Schubladenraum (25) aufweist; einer UV-Sterilisationsvorrichtung (3), die an der Schublade (2) angeordnet ist; einer Stromquelle (4), die elektrisch mit der UV-Sterilisationsvorrichtung (3) verbunden ist; einer Steuerschaltung (5), die elektrisch mit der Stromquelle (4) und der UV-Sterilisationsvorrichtung (3) verbunden ist; und einem Sensor (6), der elektrisch mit der Steuerschaltung (5) verbunden ist.
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LĂŒftungssystem fĂŒr einen mit öffnbaren Fenstern (16) ausgestatteten GebĂ€uderaum, gekennzeichnet dadurch, dass es ein GehĂ€use (18) und einen Ventilator (20) aufweist, wobei durch das GehĂ€use eine vom Ventilator erzeugte Luftströmung strömen kann, wobei das GehĂ€use dafĂŒr eine Einströmöffnung (24) fĂŒr Luft und eine Ausströmöffnung (22) fĂŒr Luft enthĂ€lt, wobei eine der beiden Ăffnungen der Form eines Ăffnungsspalts (26) zwischen einem FensterflĂŒgel (12) und einem Blendrahmen (14) des Fensters (16) angepasst ist.
Recovering from the Emotional Challenges of the Pandemic - A psychologist considers the possible effects of a global experience of long-term stress. - link
Clubhouse Feels Like a Party - But is it a good one? - link
The Movement to Exclude Trans Girls from Sports - The opposition is cast as one between cis-girl athletes on the one hand and a vast liberal conspiracy on the other. - link
Bidenâs New Deal and the Future of Human Capital - The President introduced the first part of his economic program, involving airports and bridges. The second, which invests in âhuman infrastructure,â could define his Administration. - link
What Alexey Navalny Is Experiencing in Prison - As the Russian opposition leaderâs health appears to deteriorate, plans are under way for more mass protests demanding his release. - link
+Working remotely can be a boon or a bust for your taxes, depending on where you live. +
++The pandemic has accelerated the move to remote work and with it the possibility that those employees can live anywhere they please. That could mean a higher standard of living and a lower income tax rate for the growing number of remote workers. But in some instances it could mean having to pay taxes for a place where they now neither live nor work â or even being taxed on the same income twice. +
++It can be a very complicated situation, and the internet abounds with people trying to figure out whatâs going on. Reddit, specifically, is full of questions about where remote workers should file their taxes this year: If you quarantined with family for a couple months in a different state than where you work but didnât update your tax withholdings, do you have to file two state tax returns? If you worked remotely in a state without income tax but your job is in a state that has income tax, do you have to pay it? What do you do if youâre being taxed by a state you havenât set foot in? +
++The answers, unsatisfyingly, depend on a number of factors, including which states and how long you were there, according to tax experts we spoke with. Ahead of tax season, hereâs what to look out for when filing your taxes on remote work. +
++Generally, your income tax is based on where youâre physically located when earning the income. So, if your jobâs office is in state A, but because of the pandemic youâre living and working full time in state B, youâd pay income and all other taxes to state B. If state B has lower income taxes than state A, that would be a boon for remote workers who moved. It could also be a reason for more people to pull up stakes now that theyâre less tethered to the office. +
++Taxes are, of course, more complicated than that, especially if your job happens to be based in one of seven convenience of the employer, or âconvenience rule,â states â Arkansas, Connecticut, Delaware, Nebraska, New York, Pennsylvania and, since the pandemic, Massachusetts â while youâre living and working elsewhere. +
++The convenience rule can obligate employees to pay income tax to states they might now never step foot in, since it taxes income based on the location of the employerâs office. Typically, when this happens, the state where the person lives would award a tax credit to offset taxes in the state where that person works. But in some cases, when the worker is totally living and working in a state, that state might rightfully want to tax that income and not offset taxes for the non-living, non-working state, leading to cases of double taxation, according to tax policy nonprofit Tax Foundation. +
++To avoid this, itâs important to notify your job where youâre living so it can withhold tax from the correct state. Itâs also important to consult a tax professional, since the tax situation â as well as what it takes to be a resident of that particular state â varies drastically by state and is far from intuitive. +
++If your job is in California but youâre living full-time and working remotely in Texas, for example, you wouldnât have to pay taxes on your wages, since Texas doesnât have income tax. If your job is in New York, a convenience rule state, but you lived and worked in Texas, you would have to pay New York income tax. If your job is in New York but you lived and worked in Virginia, itâs possible youâd have to pay income tax in both states. Even when states provide a credit, workers will have to shoulder that double tax burden until their tax returns come. +
++So the convenience rule can feel very inequitable. +
++âIf youâre not doing anything to avail yourself of that statesâ government services or resources, not only does it seem unfair but it creates conflicts with every other stateâs income tax code,â Jared Walczak, vice president of state projects at Tax Foundation, told Recode. +
++As with many things that happened during the pandemic, decisions about remote work often happened swiftly and without much planning. As a result, the majority of Americans who worked remotely during the pandemic werenât aware of the possible tax consequences of working remotely and werenât aware they had to change state tax withholding to match where they were actually living, according to a Harris Poll on behalf of the American Institute of CPAs (AICPA). Nearly half didnât know each state has different laws related to remote work. +
++Itâs also not clear how many people are moving to different states to work remotely, since thereâs a lag in IRS data. But moving data from United Van Lines last year suggests people are increasingly moving from states with high taxes to states with lower or no income taxes. A McKinsey Global Institute analysis of 800 jobs found that the ability to work remotely is highly concentrated in a handful of high-skill occupations and industries, including finance, management, professional services, and information technology. +
++Catherine Stanton, vice-chair of the AICPAâs state and local tax committee, says sheâs fielded an increasing number of questions about out-of-state remote situations from clients, both employees and employers. +
++âI think itâs happening a lot, for sure,â Stanton said. And depending on where your job is and where you live, it can be financially beneficial. âI think itâs a great strategy,â she added, âbut you have to make sure youâre not working for those employers that have convenience of the employer rules and then maybe you pressure those employers to set up an office somewhere else.â +
++If you work at a larger company, for example, they can assign you to an office outside of convenience rule states so you can avoid being taxed by a state you arenât in, Stanton said. The Tax Foundationâs Walczak said that by looking for short-term tax windfalls, convenience rule states might lose long-term tax gains by driving businesses elsewhere. +
++One should also note that states without income tax often make up for it with higher sales, property, and other taxes. There are trade-offs between what those states buy with that tax (think schools and roads). +
++For now, some governments are trying to alleviate the situation. A number of states have allowed people currently telecommuting to be taxed in the state where their job is located. New Hampshire, where many people who work for firms in Massachusetts currently live and work, filed suit in the Supreme Court over Massachusetts continuing to collect income tax on people working remotely in New Hampshire, which doesnât collect income tax. A number of other states, including New Jersey, Connecticut, and Iowa, have filed amicus briefs in the case. Thereâs also bipartisan interest at the federal level to stop the practice, including proposed legislation called the Multi-State Worker Tax Fairness Act of 2020 that would tax remote workers by residence only. +
++For now, though, remote employees â and tax professionals â are going to have to navigate labyrinthine state tax laws one by one. +
+Sure, there are some similarities. But Bidenâs foreign policy is very, very different from Trumpâs. +
++Thereâs a growing argument, coming mostly from the left, that President Joe Bidenâs foreign policy is essentially the same as former President Donald Trumpâs. +
++It goes something like this: Two months into his administration, Biden is pursuing many of the same objectives as his predecessor. Sure, the tone has changed â namely, talk of rebuilding alliances and defending democracy and human rights â but much of the substance remains the same. +
++For example, Biden has taken an adversarial stance toward China and Russia; sold billions in weapons to a dictator in Egypt; kept the economic sanctions Trump imposed on Iran and the International Criminal Court (ICC) in place; declined to sanction Saudi Crown Prince Mohammed bin Salman for his role in ordering the killing of Washington Post columnist Jamal Khashoggi; and is unlikely to drastically slash the Pentagon budget. +
++In effect, they argue that US foreign policy right now is Trumpâs with Bidenesque characteristics. +
++That critique is coming from a small but vocal chorus of analysts, activists, and noted commentators like Noam Chomsky. Stephen Miles, executive director of the progressive foreign policy group Win Without War, recently told Politico that âThereâs this fear of being attacked on the right of not being tough enough on China or Iran or other issues.â The problem, he adds, is âthere doesnât seem to be as much concern about the overwhelming majority of the Democratic Party.â +
++Itâs a provocative case, but itâs not very convincing. While there are some similarities between the two presidents, Biden and Trump have extremely different foreign policies. Any claims that theyâre the same are incomplete at best. +
++In December, I wrote a story about how Biden wanted the US to pursue a traditional, post-World War II foreign policy to defend the âliberal international orderâ â essentially the diplomatic and economic rules and norms that run the world. As Biden formed a team to do just that, progressives I interviewed couldnât mask their displeasure. +
++âAmericans are looking for a complete, fundamental shift in US foreign policy,â Yasmine Taeb, a senior fellow at the progressive Center for International Policy whoâs leading the leftâs critique of Bidenâs team, told me at the time. âI hope they recognize that the vast majority of the American people have rejected establishment foreign policy and the trajectory that weâve been on for decades.â +
+ ++Now, Taeb and others are essentially saying, âI told you so.â They argue that two months into Bidenâs presidency, itâs clear that âcomplete, fundamental shift in US foreign policyâ hasnât happened yet. What Americans have gotten instead is a Biden foreign policy that echoes Trumpâs more than progressive critics like. +
++Take Biden selling $200 million in missiles to Egypt, a country led by a dictator who has routinely violated human rights, jailing thousands of political dissidents and killing hundreds more. Bidenâs detractors compare that to Trumpâs decision to sell $8 billion worth of weapons to Saudi Arabia, even after Crown Prince Mohammed bin Salman ordered the 2018 murder of US resident Jamal Khashoggi. +
++They also point out that Bidenâs team hasnât lifted sanctions the Trump administration placed on the ICC. Trump took that action because the ICC was considering opening two investigations: one into alleged war crimes committed by US troops during the Afghanistan war, and one into alleged war crimes committed by Israelis and Palestinians during the 2014 Gaza War; the court was also considering making a determination on whether Israeli settlements in the West Bank constitute a war crime. +
++Two months in, Bidenâs team has kept those sanctions in place. Itâs not exactly clear why; when asked by reporters, the administration usually declines to comment. But Axios and the Guardian last month noted that Jerusalem is lobbying allies, including the US, to keep the financial pressure on the court in hopes that it will drop the case. +
++That rationale â that the Biden administration is keeping Trumpâs sanctions on partly at Israelâs behest â tracks with comments some US officials have made. +
++âWe have serious concerns about the ICCâs attempts to exercise its jurisdiction over Israeli personnel,â State Department spokesperson Ned Price said in a February statement. âThe United States has always taken the position that the courtâs jurisdiction should be reserved for countries that consent to it, or that are referred by the UN Security Council.â +
++For these and the other reasons cited above, critics say Bidenâs foreign policy represents more continuity than change from the Trump years. That seems fair on the surface, but the truth is Bidenâs foreign policy is nothing like Trumpâs. Not even close. +
++Consider either what Biden has done or has said he wants to do on foreign policy: +
++Thereâs more, but itâs already notable that Biden and Trump just donât see the world the same way. +
+ ++Whatâs more, Bidenâs different tone â defending democracy and supporting human rights, among other things â is in itself a substantive policy change from the Trump years. +
++âI made it clear that no American president [should] ever back down from speaking out of whatâs happening to the Uyghurs, whatâs happening in Hong Kong, whatâs happening in-country,â Biden said during a press conference last week about his conversations with Chinese President Xi Jinping. +
++âThe moment a president walks away from that, as the last one did, is the moment we begin to lose our legitimacy around the world,â he continued. âItâs who we are.â +
++Biden has followed through on his rhetoric by sanctioning Chinese officials for human rights abuses against the Uyghurs in Xinjiang and for cracking down on Hong Kongâs democracy. +
++But donât take it from me or Biden. Trump administration officials also note the wide gap between the current presidentâs positions and the old oneâs. +
++Indeed, the list above didnât just come from my head. It came from conversations with Trump-era staff who said US foreign policy would be âa bit different,â according to one, if the Republican had won a second term. +
++Among other things, they said the US wouldnât have extended New START for five years, rejoined the WHO, lifted the terrorist label on the Houthis, or pushed for a return to the UN Human Rights Council. +
++And already former Trump administration officials, like then-Deputy Assistant Secretary of Defense Elbridge Colby, are blasting Biden for pursuing a foreign policy built around defending democracy and human rights instead of pure national interests. +
++âThe central theme of President Bidenâs foreign policy is a global, muscular liberalism,â he wrote in the Washington Post last week. âBut it is not a sensible policy today,â he wrote, partly because the US is no longer the unquestioned global power. +
++While he didnât specifically mention Trump in the piece, he argued the more economic-focused course Trump took â âmaking sure we can determine our future free of external coercion and being able to trade and invest overseas on terms that promote a broad-based national prosperityâ â would be better. +
++So no, Bidenâs foreign policy isnât nearly the same as Trumpâs. But the meme persists, it seems, mostly because Biden has yet to return the US to the Iran nuclear deal. +
++Those who argue Biden is pursuing a Trump-like foreign policy have one overriding complaint: that Biden hasnât lifted Trump-imposed sanctions on Iran as a way to return swiftly to the nuclear pact â a decision praised by Jared Kushner, Trumpâs senior adviser and son in law. +
++But Bidenâs team says the situation isnât as simple as progressives and Iran doves make it out to be. Tehran is in violation of the agreement, namely by enriching uranium at levels beyond caps outlined in the deal. Until the US can verify Iran has come back into compliance, thereâs no reason to remove the economic leverage America has. +
+ ++Indeed, Bidenâs team feels they inherited a bad situation. After Trump withdrew the US from the pact in 2018, Iran decided to violate the deal as a way to pressure the US back into the accord. Dropping the sanctions now, some in the new administration would say, rewards Tehran for no longer abiding by the nuclear dealâs terms. +
++Hence the delay. The US would âhave to evaluate whether they were actually making good if they say they are coming back into compliance with their obligations, and then we would take it from there,â Secretary of State Tony Blinken said in his January confirmation hearing. +
++But even here thereâs a yawning gap between how Trump and Biden handle the issue. The Trump administration wanted Iran to change nearly every aspect of its foreign policy before winning sanctions relief. Biden just wants Iran to abide by the nuclear pact again, and has even proposed partial sanctions removal for partial compliance. +
++Ryan Tully, who served as a top official on Trumpâs National Security Council, confirmed his team wouldâve pursued a different course. âWe wouldnât give sanctions relief to get to the negotiating table with Iran,â he told me. +
++The US may not be back in the nuclear deal, then, but itâs at least trying to get there. âBiden is offering Tehran a way out that doesnât involve either its capitulation or collapse,â said Henry Rome, an expert on US policy toward Iran at the Eurasia Group consulting firm. âItâs a very different ballgame.â +
++âA very different ballgameâ goes not only for Bidenâs Iran policy, but his entire foreign policy. There are clearly some similarities between the last two administrations â itâs been only two months, after all â but overall, they are vastly different. +
+The network will soon feature multiple shows hosted by former Trump administration officials. +
++Fox News fancies itself, at least outside of its Hannity-style programming, as a journalistic outlet. But its recent string of hires tells a different story. +
++Despite the Trump administrationâs legacy of unrelenting dishonesty and Trumpâs recent turn against Fox, the network has hired several former Trump officials of late, basically becoming a jobs program for any former Trump aide who desires gainful employment â and ensuring that Trumpâs brand of politics will have a regular, prominent place on national television. +
++On Tuesday, the network announced that former Trump administration press secretary Kayleigh McEnany will be co-hosting the weekday afternoon Outnumbered talk show starting April 6. That announcement came just a few weeks after Fox News first hired McEnany as a contributor. As press secretary, McEnany is perhaps best remembered for castigating reporters and providing misleading spin â such as making a mockery of the Hatch Act by working for the White House and Trump campaign at the same time, and insisting that Trumpâs loss to Joe Biden was tainted by fraud when she couldnât produce a single example of an illegal ballot being cast. +
+++McEnany canât cite a single specific example of an âillegal voteâ being cast pic.twitter.com/H6ul298p1K +
+â Aaron Rupar (@atrupar) November 9, 2020 +
+In a statement announcing her promotion, Fox News CEO Suzanne Scott whitewashed McEnanyâs past, and instead said her âunique background in politics and law coupled with her experiences confronting womenâs health challenges and life as a new mom will add robust insight to Outnumbered.â +
++News of McEnanyâs promotion came just a day after Lara Trump, a former senior Trump campaign official and the daughter-in-law of Donald Trump, announced during a Fox & Friends appearance that sheâs been hired as a contributor, while basically acknowledging that Fox News served as an unofficial arm of the Trump campaign. +
++âI sort of feel like Iâve been an unofficial member of the team for so long,â she said. âYou guys know it was kinda a joke, over the past five years I would come there so often that the security guards were like, âMaybe we should just give you a key.ââ +
++++Fox hired Lara Trump
+â Lis Power (@LisPower1) March 29, 2021 +
Ainsley: Letâs bring in Lara Trump, fmr senior advisor for the Trump campaign, and we have a big announcement, she is a new Fox News contributor. Welcome to the family, Lara.
Lara: I sort of feel like Iâve been an unofficial member of the team for so long pic.twitter.com/doofIJomDO +
+In addition to bringing aboard McEnany and Lara Trump, the network gave former Trump administration economic adviser Larry Kudlow his own show on Fox Business. And while he hasnât been hired by Fox, former Trump adviser Stephen Miller â known for helping to develop Trumpâs nativist immigration policy â has become a fixture as a guest on Sean Hannityâs and Laura Ingrahamâs shows. +
++Thereâs an irony to this hiring spree, given how angry Trump was at Fox News in the weeks following the election for what he took to be the networkâs disloyalty. +
++During the campaign, Trump took umbrage because Fox wouldnât rig polls for him and sometimes booked Democrats for interviews, but things boiled over after the network foiled his plan to prematurely declare victory on election night with its early call of Arizona for Biden. +
++Trump eventually pivoted from bashing Fox to explicitly promoting its Trumpier competitors, Newsmax and OAN. +
++â.@FoxNews daytime is not watchable. In a class with CNN & MSDNC. Check out @OANN, @newsmax and others that are picking up the slack,â he tweeted on December 6. âEven a boring football game, kneeling and all, is better!â +
++Trumpâs promotion of Newsmax and OAN initially appeared to have an impact. Fox Newsâs ratings slumped relative to MSNBC and CNN during the period between November 3 and the January inauguration. Newsmax, meanwhile, competed with Fox News from the other side of the ideological spectrum, even scoring its first ever ratings win in December. +
++But the January 6 insurrection marked a turning point of sorts. Trumpâs subsequent banishment from Twitter and Facebook brought an end to his days of live-tweeting cable news, and Fox Newsâs ratings stabilized (albeit at a lower level from a year earlier) after he left office and the relevance of the MAGA propaganda programming on offer from Newsmax and OAN waned. +
++In general, Trumpâs departure from the White House has hurt ratings across the cable news networks, as the relative order of the Biden administration makes for less compelling viewing than the chaos of the Trump days. +
++But now that heâs been deplatformed, Trump needs Fox News more than ever. +
++Instead of promoting Newsmax or denigrating Fox in the tweet-like statements heâs been releasing through his ex-presidential office â statements that are largely ignored by the mainstream press â Trump has steered clear of media criticism. And in recent weeks, heâs kept himself in the public eye by calling in to Fox News for softball interviews with hosts Harris Faulkner, Laura Ingraham, and Jeanine Pirro where heâs able to lie with impunity. +
++++Trump pushes the big lie live on Fox News, gets no pushback from Harris Faulkner pic.twitter.com/WOLjsy8WXG +
+â Aaron Rupar (@atrupar) March 22, 2021 +
+While thereâs ample precedent for former White House officials making the leap into news media when their tenure in government is through â George Stephanopoulos went from the Clinton White House to ABC News, for example, and Dana Perino went from the George W. Bush White House to Fox News â the volume of former Trump officials Fox News has hired is notable, particularly because Fox News staffing itself with Trump family members and former staffers will keep Trumpism relevant. +
++Lara Trump, for example, is still teasing a possible 2022 US Senate run in North Carolina even though she was just hired as a commentator for Fox. And Kayleigh McEnanyâs installation as a daytime host means that the political news of the day will be filtered through a MAGA lens. +
++Donald Trump, meanwhile, can self-promote by calling in to friendly hosts who will let him opine about Bidenâs purported failures on national TV, even if he can no longer post tweets. +
++It wonât be good journalism, but thatâs rarely the point with Fox. What it will do is help Trump maintain control over the Republican Party heading into the 2022 midterms â and beyond. +
++
+IPL 2021 | Hazelwood pulls out for the sake of international season - The pace bowler aims to be in his best mental and physical form ahead of the long international calendar.
Auckland to host 2023 womenâs World Cup opener, final in Sydney - Melbourne, Brisbane, Adelaide and Perth will also host games in Australia, with New Zealandâs Dunedin, Hamilton and Wellington completing the nine host cities for the global showpiece.
Rajasthan Royals team preview | Cellar dwellers last year, new-look RR eye the penthouse - After finishing bottom in 2020, Rajasthan has ambitions of climbing to the top with a new captain and director of cricket, and IPLâs most expensive player ever
âYou need to perform no matter the price tag,â says Chris Morris - Morris says he and Stokes would be an interesting duo to come up against
ITF womenâs tennis | Riya Bhatia bows out - Qualifier Riya Bhatia was beaten 6-2, 6-4 by Anastasia Zakharova of Russia in the pre-quarterfinals of the $25,000 ITF womenâs tennis tournament here
India committed to cooperation under BIMSTEC framework: Jaishankar - India remains committed to further building the momentum of regional cooperation under the framework of BIMSTEC and make it a stronger, vibrant and
Tamil Nadu Assembly polls | DMK has no concern for women, says Amit Shah - Union Home Minister says former Chief Minister MGRâs welfare policies had earned him a reputation across the country.
LDF, UDF supporting jihadis: Yogi - âState yet to pass a legislation against âlove jihadâ despite HC directiveâ
Punjab CM backs commission agents on DBT issue - âArhtiyas are the backbone of the successful procurement system in the Stateâ
In Thoothukudi district, swipe a card to get potable water - An initiative of IIT-Madras and IOCL, it has helped villagers in two panchayats
Covid: Europeâs vaccine rollout âunacceptably slowâ - WHO - The WHO says the situation in the wider Europe region is more worrying than it has been in several months.
Venice bans cruise ships from historic centre - Critics argue the ships erode the cityâs foundations and cause flooding and pollution.
Dutch government to let 3,500 fans watch Eurovision Song Contest - The song contestâs Dutch venue would be half full and fans would need a negative Covid test.
Putin critic Navalny on hunger strike over Russian prison treatment - Russiaâs leading opposition figure demands access to a doctor of his choice to treat serious back pain.
Italian officer âcaught selling secrets to Russiaâ - Military police say they detained a navy officer as he exchanged documents with a Russian official.
North Korean hackers return, target infosec researchers in new operation - Google outs the new op two months after shutting down a previous campaign. - link
Physicists give antimatter the chills - If anythingâs odd about antimatter, we need to slow it down enough to see it. - link
Factory mix-up spoils 15 million doses of J&J COVID vaccine - The error at a manufacturing facility will delay future shipments of the vaccine. - link
Trial started for vaccine against one of the scariest coronavirus variants - The vaccine is being developed âout of an abundance of caution,â Fauci says. - link
HoloLens for 120,000 Army personnel: Microsoft inks $21.9 billion deal - Was originally pegged at $480 million in 2018, follows scrutiny over other DOD deals. - link
+He should have his cabinet together by the end of the week. +
+ submitted by /u/4x4Xtrm
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+A stormtrooper +
+ submitted by /u/KarateKid84Fan
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+As soon as he gets it home, the rooster fucks all the farmerâs 150 hens. The farmer is impressed. At lunch, the rooster screws all 150 hens again. +
++The next day, the rooster fucks the ducks and the geese. Sadly, later that day, the farmer finds the rooster laying on the ground half-dead with vultures circling overhead. The farmer says, âyou deserve it, you horny bastard.â +
++The rooster opens one eye and says âShhhh, theyâre about to land!â +
+ submitted by /u/Bigringcycling
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+They couldnât smell what the rock was cooking. +
+ submitted by /u/potato_fish12
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+There Once Was A Poet Named Bates, +
++His poems werenât always first rate, +
++His first lines werenât bad, but the problem he had, +
++Was that he always tried to put too many syllables into the last line. +
+ submitted by /u/b_ootay_ful
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