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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase III Double-blind, Placebo-controlled Study of AZD7442 for Post- Exposure Prophylaxis of COVID-19 in Adults</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: AZD7442;   Drug: Placebo<br/><b>Sponsors</b>:   AstraZeneca;   QuintilesIMS<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult.</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: AZD7442;   Drug: Placebo<br/><b>Sponsors</b>:   AstraZeneca;   QuintilesIMS<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: FSD201;   Drug: Placebo<br/><b>Sponsor</b>:   FSD Pharma, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hyperimmune Plasma for Patients With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: treated with hyperimmune plasma<br/><b>Sponsor</b>:   ANNA FALANGA<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intravenous Infusion of CAP-1002 in Patients With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: CAP-1002;   Biological: Placebo<br/><b>Sponsor</b>:   Capricor Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Clarithromycin 500mg;   Drug: Azithromycin;   Drug: Placebo<br/><b>Sponsor</b>:   South Valley University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Probiotics in Reducing Symptoms of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: Probiotics (2 strains 10x10^9 UFC);   Dietary Supplement: Placebo (potato starch and magnesium stearate)<br/><b>Sponsors</b>:   Centre de recherche du Centre hospitalier universitaire de Sherbrooke;   Lallemand Health Solutions<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of ZnAg Liquid Solution to Treat COVID-19 Symptomatic Participants</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: CNM-ZnAg;   Drug: Placebo<br/><b>Sponsors</b>:   Clene Nanomedicine;   ICL Pharma;   Azidus Brazil<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Two Hyperimmune Equine Anti Sars-CoV-2 in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: Administration of Equine immunoglobulin anti SARS-CoV-2<br/><b>Sponsors</b>:   Caja Costarricense de Seguro Social;   Universidad de Costa Rica;   Ministry of Health Costa Rica<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mesenchymal Stem Cells in Patients Diagnosed With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: MSC;   Drug: Control<br/><b>Sponsors</b>:   Hospital Reg. Lic. Adolfo Lopez Mateos;   Instituto de Terapia Celular: ITC<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVI-VAC;   Other: Placebo<br/><b>Sponsor</b>:   Codagenix, Inc<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Diagnostic Performance Evaluation of a Novel SARS-CoV-2 (COVID-19) Antigen Detection Test</strong> - <b>Conditions</b>:   Covid19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Diagnostic Test: RT-qPCR test;   Diagnostic Test: COVID-VIRO® test<br/><b>Sponsor</b>:   Centre Hospitalier Régional dOrléans<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>plasmApuane CoV-2 : Efficacy and Safety of Immune Covid-19 Plasma in Covid-19 Pneumonia in Non ITU Patients</strong> - <b>Condition</b>:   Covid-19 Pneumonia<br/><b>Intervention</b>:   Biological: immune plasma<br/><b>Sponsor</b>:   Azienda USL Toscana Nord Ovest<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the Efficacy of Xylitol Nasal Spray Against SARS-CoV-2</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Nasal Spray<br/><b>Sponsors</b>:   Larkin Community Hospital;   Ferrer Medical Innovations;   Xlear<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Use Acetyl L-Carnitine in Patients With Covid-19 Pneumonia</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Dietary Supplement: Acetyl L-Carnitine<br/><b>Sponsor</b>:   Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target</strong> - Rapid accumulation of viral proteins in host cells render viruses highly dependent on cellular chaperones including heat shock protein 90 (Hsp90). Three highly pathogenic human coronaviruses, including MERS-CoV, SARS-CoV and SARS-CoV-2, have emerged in the past 2 decades. However, there is no approved antiviral agent against these coronaviruses. We inspected the role of Hsp90 for coronavirus propagation. First, an Hsp90 inhibitor, 17-AAG, significantly suppressed MERS-CoV propagation in cell…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management</strong> - At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as M(Pro) inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)</strong> - OBJECTIVES: The aim of this study was to use Ligand-based pharmacophore modelling approach for four established antiviral drugs, namely remdesivir, lopinavir, ritonavir and hydroxychloroquine for COVID-19 inhibitors as training sets. In this study Twenty vanillin derivatives together with monolaurin and tetrodotoxin were used as test sets to evaluate as potential SARS-CoV-2 inhibitors. The Structure-based pharmacophore modelling approach was also performed using 5RE6, 5REX and 5RFZ in order to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Camostat Mesylate against SARS-CoV-2 and COVID-19 - Rationale, Dosing and Safety</strong> - The coronavirus responsible for COVID-19, SARS-CoV-2, utilizes a viral membrane spike protein for host cell entry. For the virus to engage in host-membrane-fusion, SARS-CoV-2 utilizes the human transmembrane surface protease, TMPRSS2, to cleave and activate the spike protein. Camostat mesylate, an orally available well-known serine protease inhibitor, is a potent inhibitor of TMPRSS2 and has been hypothesized as a potential antiviral drug against COVID-19. In vitro human cell and animal studies…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Favipiravir and COVID-19: A Simplified Summary</strong> - A recent outbreak of coronavirus disease 2019 (COVID-19) caused by the novel coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started in Wuhan, China, at the end of 2019 and then spread rapidly all over the world. However, there are no specific antiviral therapies for COVID-19, using the agents which approved or in development for other viral infections is one of the potentially quickest ways to find treatment for this new viral infection. Favipiravir is an…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular basis for drug repurposing to study the interface of the S protein in SARS-CoV-2 and human ACE2 through docking, characterization, and molecular dynamics for natural drug candidates</strong> - A novel coronavirus (SARS-CoV-2) identified in Wuhan state of China in 2019 is the causative agent of deadly disease COVID-19. It has spread across the globe (more than 210 countries) within a short period. Coronaviruses pose serious health threats to both humans and animals. A recent publication reported an experimental 3D complex structure of the S protein of SARS-CoV-2 showed that the ectodomain of the SARS-CoV-2 S protein binds to the peptidase domain (PD) of human ACE2 with a dissociation…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational Hot-Spot Analysis of the SARS-CoV-2 Receptor Binding Domain / ACE2 Complex</strong> - Infection and replication of SARS CoV-2 (the virus that causes COVID-19) requires entryto the interior of host cells. In humans, a Protein-Protein Interaction (PPI) between theSARS CoV-2 Receptor-Binding Domain (RBD) and the extracellular peptidase domain ofACE2, on the surface of cells in the lower respiratory tract, is an initial step in the entrypathway. Inhibition of the SARS CoV-2 RBD / ACE2 PPI is currently being evaluated asa target for therapeutic and/or prophylactic intervention….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The other possible mechanism of the benefits of RAAS inhibition in the athogenesis of COVID-19</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure of nonstructural protein 1 from SARS-CoV-2</strong> - The periodic emergence of novel coronaviruses (CoVs) represents an ongoing public health concern with significant health and financial burden worldwide. The most recent occurrence originated in the city of Wuhan, China where a novel coronavirus (SARS-CoV-2) emerged causing severe respiratory illness and pneumonia. The continual emergence of novel coronaviruses underscores the importance of developing effective vaccines as well as novel therapeutic options that target either viral functions or…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eculizumab as an emergency treatment for adult patients with severe COVID-19 in the intensive care unit: A proof-of-concept study</strong> - BACKGROUND: Complement pathway inhibition may provide benefit for severe acute respiratory illnesses caused by viral infections such as COVID-19. We present results from a nonrandomized proof-of-concept study of complement C5 inhibitor eculizumab for treatment of severe COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Adaptive Evolution of Peptide Inhibitors for Mutating SARS-CoV-2</strong> - The SARS-CoV-2 virus is currently causing a worldwide pandemic with dramatic societal consequences for the humankind. In the past decades, disease outbreaks due to such zoonotic pathogens have appeared with an accelerated rate, which calls for an urgent development of adaptive (smart) therapeutics. Here, a computational strategy is developed to adaptively evolve peptides that could selectively inhibit mutating S protein receptor binding domains (RBDs) of different SARS-CoV-2 viral strains from…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Early Effects of the COVID-19 Pandemic on Physical Activity Locations and Behaviors in Adults Living in the United States</strong> - COVID-19 restrictions and social-distancing may inhibit adults from attaining recommended levels of physical activity. This study examined early impact of COVID-19 pandemic on physical activity in adults during the first two months of restrictions in the U.S. and how physical activity locations were associated with physical activity levels during this period. Adults (N = 268) completed an online survey between April 10-May 25, 2020. Participants reported minutes of vigorous, moderate, and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Biomimetic Human Disease Model of SARS-CoV-2 Induced Lung Injury and Immune Responses on Organ Chip System</strong> - Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The models that can accurately resemble human-relevant responses to viral infection are lacking. Here, we create a biomimetic human disease model on chip that allows to recapitulate lung injury and immune responses induced by SARS-CoV-2 in vitro at organ level. This human alveolar chip reproduced the key features of alveolar-capillary barrier by co-culture of human…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Solar heating to inactivate thermal-sensitive pathogenic microorganisms in vehicles: application to COVID-19</strong> - Disinfection is a common practice to inhibit pathogens, yet success is limited by microbial adaptation and our poor knowledge of viral transmission, notably in the current COVID-19 pandemic. There is a need for alternative disinfection strategies and techniques that are adapted to the actual behavior of humans living in densely populated mega-cities. Here, high public circulation in shared passenger vehicles such as taxis, buses and personal cars represents a major risk of viral transmission due…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 예방을 위한 mRNA기반 항원보강제 혼합물 합성 방법</strong> - 본 발명은 SARS-CoV-2(코로나 바이러스) 예방을 위한 mRNA 항원보강제에 관한 것으로 코로나 바이러스에 대한 백신으로서 상기의 항원에 대한 예방을 목적으로 하고 있다. 아이디어에는 보강제에 해당하는 완전프로인트항원보강제(CFA)와 불완전프로인트항원보강제(IFA), 번역과 안정성의 최적화가 된 mRNA, mRNA 운반체, 양이온성 지질 나노입자(lipid nanoparticles)로 구성되며 기존의 백신에 비해 효율성과 안정성의 측면에서 더 향상된 효과를 가지고 있다.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Methods for treating Arenaviridae and Coronaviridae virus infections</strong> - Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I:</p></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">wherein the position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Atemschutz-Baukastensystem</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Atemschutz-Baukastensystem, das aufweist:</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">eine auf zumindest Mund und Nase einer Person aufsetzbare Maske (1), die einen Eingang (11) und einen Ausgang (12) aufweist, und</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">mindestens einen Schlauch (3, 31, 32),</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">wobei sämtliche Komponenten des Atemschutz-Baukastensystems modular ausgebildet und über Steckverbindungen oder Schraubverbindungen (115, 125, 155, 165, 175, 215, 315, 75, 915) miteinander verbindbar sind, um der Maske (1) Luft über deren Eingang (11) zuzuführen und/oder ausgeatmete Luft vom Ausgang (12) der Maske (1) wegzuführen.</li>
</ul>
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<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vorrichtung zur Übergabe und Dekontamination von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Vorrichtung zur Übergabe von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen nach einer Dekontamination, umfassend eine Einrichtung zur Dekontamination der mit Krankheitserregern kontaminierten Gegenstände oder Erzeugnisse mit mindestens einer UV-Strahlungsquelle (24), eine Durchzugseinrichtung mit Ein- und/oder Ausgabebereichen für die kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse, dadurch gekennzeichnet, dass die Durchzugseinrichtung im Eingang bzw. im Ausgang zum Ein- und/oder Ausgabebereich angeordnete sich paarweise gegenüberliegende Walzen (17) und Räder (4) umfasst, die zum Einzug bzw. zur Ausgabe der kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse vorgesehen sind, wobei die Walzen (17) und die Räder (4) durch im Ein- und/oder Ausgabebereich angeordnete Sensoren (23) und einer elektronische Kontrolleinheit (27) in Bewegung bringbar sind, wobei die Gegenstände oder Erzeugnisse in den Bereich der Einrichtung zur Dekontamination förderbar sind, der zwischen den paarweise angeordneten Walzen (17) und Rädern (4) vorgesehen ist, welcher sich gegenüberliegende Platten (25) aus Quarzglas oder einem UV-transparenten Polymermaterial, wie Graphen oder Kunstglas umfasst, über bzw. unter welchen die UV-Strahlungsquelle (24) angeordnet ist, welche als UVC-LED-Leiste und/oder Modul mit mindestens einer LED-Lampe ausgebildet ist.</p></li>
</ul>
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<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물</strong> - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. [화학식 1] .</p>
<pre><code> JPEG
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135</code></pre></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>新型冠状病毒中和性抗体滴度检测ELISA试剂盒</strong> - 本发明提供一种新型冠状病毒中和性抗体滴度检测ELISA试剂盒其中包括包被有生物素链霉亲和素标记的人ACE2蛋白的酶标板、辣根过氧化酶标记的新型冠状病毒RBD蛋白、新型冠状病毒中和性抗体阳性对照、包被液、洗涤液、稀释液、封闭液、显色液和终止液等。该试剂盒具有成本低操作简单高灵敏度、高特异性、高准确度的特点可用于新型冠状病毒中和抗体的批量、快速检测。</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Zahnbürstenaufsatz, elektrische Versorgungseinheit einer elektrischen Zahnbürste, elektrische Zahnbürste mit einem Zahnbürstenaufsatz, Zahnbürste sowie Testaufsatz für eine elektrische Zahnbürste</strong> -</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wasserpfeife mit Hygienefunktion</strong> -
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Hygiene-Mundstückelement (100), aufweisend einen ersten Endabschnitt (103), welcher ausgebildet ist zur Verbindung mit einem Griff-Mundstückelement (200) einer Wasserpfeife (400) und aufweisend einen zweiten Endabschnitt (104), welcher als mundseitiges, freies Ende ausgebildet ist, wobei das Hygiene-Mundstückelement (100) ein erstes Filterelement (101) aufweist, wobei das erste Filterelement (101) wenigstens ein adsorbierendes Material umfasst und/oder wobei das Hygiene-Mundstückelement (100) ein zweites Filterelement (102) aufweist, wobei das zweite Filterelement (102) Metalloxid und/oder elektrostatisch geladene Fasern umfasst.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>알츠하이머병 혹은 뇌졸중의 뉴로인플라마섬의 치료제로서 디디에스 혹은 그 유도체</strong> - 목표 / 배경 :이 연구는 신경-정신과 증상을 측면과 구별하기 위해 2018 NIA-AA 연구 프레임 워크’에 따라 뉴로인플라마섬 경쟁자로서 4, 4- 디아미노디 페닐설폰(DDS, 디디에스)으로 치료받은 알츠하이머병(AD) 환자를 조사했습니다. 방법 : 서울 연구에서는 AD 진단 기준에 따라 2005 년 1 월부터 2020 년 6 월까지 보관된 소록도 국립병원 EDI 데이터베이스의 AD와 항AD약물(AAD)의 효과를 분석하여 ICD-9와 10 개의 코드를 이용하여 검색 하였습니다. 새로운 바이오마커 (D)를 사용하여 AAD로 인한 AD 증상과 신경정신병적 증상을 관리하여 수치 임상 병기를 분류했습니다. 우리는 서울 연구에서 뉴로인플라마섬 경쟁자로서 뇌경색 및 DDS 관련 사례를 보고합니다. 결과 : DDS는 DDS를 처방했거나 처방하지 않은 사람들과 AD의 비율을 비교할 때 뉴로인플라마섬 경쟁자였습니다. (D)를 도입함으로써, AD의 진행은 NCS 병기 결정을 통해 모니터링 하였습니다. AAD 또는 신경병리 증상을 구별하고 DDS로 치료했습니다. AD는 AAD에 의해 악화될 수 있고 DDS에 의해 경미한 인지 장애로 회복될 수 있습니다. 우리는 서울 연구에서 뇌경색이 발생하기 전과 후에 뉴로인플라마섬 경쟁자로서 DDS가 어떤 역할을 하는지를 임상적으로 확인했습니다. 결론 : DDS는 RBS 분할에 의한 정규/비정규적 우비퀴틴화, NLRP3 inflammasome 형성, Higgins의 캐스케이드 및 철이 풍부한 강자성 나노 입자를 차단하는 역할을 합니다. 바이오마커 (D)를 통하여 DDS로 AD를 예방하고 치료할 수 있습니다. AD에 대한 예방 및 치료 방법으로 뉴로인플라마섬을 치료하는 것을 수치 임상 병기(NCS, Numeric clinical staging)를 통하여 증명하고 있습니다.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A electronic biometric system</strong> - An electronic biometric system, the system comprising:</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">a biometric detection means arranged to:</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">detect at least one biological characteristic of a person</p></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-apple-subreddit">From Apple Subreddit</a></li>
<li><a href="#from-hacker-news">From Hacker News</a></li>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-apple-subreddit">From Apple Subreddit</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>HomePod Mini Review: Big Sound, Tiny Box!</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple Silicon M1 Chip in MacBook Air Outperforms High-End 16-Inch MacBook Pro</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Serif Affinity suite is now native on M1 Apple Silicon!</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Microsoft Releases Office for Mac Beta With Apple Silicon Compatibility</strong></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>macOS Big Sur will release at 10 am PST worldwide</strong></li>
</ul>
<h1 data-aos="fade-right" id="from-hacker-news">From Hacker News</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Guido van Rossum joins Microsoft</strong> - <a href="https://news.ycombinator.com/item?id=25071847">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>macOS Big Sur is here</strong> - <a href="https://news.ycombinator.com/item?id=25072644">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Stripe is now charging 0.5% more for recurring charges</strong> - <a href="https://news.ycombinator.com/item?id=25072783">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of exercise training for five years on all cause mortality</strong> - <a href="https://news.ycombinator.com/item?id=25071676">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AWS releases Glue Databrew, a visual ETL tool</strong> - <a href="https://news.ycombinator.com/item?id=25071443">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Migrating Large Heroku Postgres Instances to AWS Aurora Without Downtime</strong> - <a href="https://news.ycombinator.com/item?id=25071502">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Exploding Whale remastered: 50th anniversary of legendary Oregon event</strong> - <a href="https://news.ycombinator.com/item?id=25070440">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Funkwhale Decentralized, self-hosted music server</strong> - <a href="https://news.ycombinator.com/item?id=25067701">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sweeps (YC W20) Is Hiring a Senior Software Engineer</strong> - <a href="https://news.ycombinator.com/item?id=25071823">Comments</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wayeb: A Complex Event Processing and Forecasting Engine</strong> - <a href="https://news.ycombinator.com/item?id=25070810">Comments</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Georgia Republicans Turn Trumps Baseless Claims of Voter Fraud Into an Electoral Strategy</strong> - In a pair of Senate runoffs, the incumbents, Kelly Loeffler and David Perdue, are clinging tightly to the lame-duck President, hoping his voters will turn out for them in January.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Seven Pillars of Bidens Foreign Policy</strong> - The world wants a mensch to make America great again.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Work of Saving Democracy Must Go On After Trump</strong> - The emergency that roused so many ordinary Americans from their complacency has now ended, but the great uncertainty is what happens next to a country that seems irretrievably divided.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>William Barrs “Radical Break” from Precedent, and the Future of the Justice Department</strong> - Wendy Weiser, who directs the Democracy Program at the Brennan Center for Justice, talks about the Attorney Generals promise of voter-fraud investigations and his track record of politicizing law enforcement to benefit Donald Trump.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>If Theres Something Valuable Under the Soil, Life Aboveground Can Be Hard</strong> - Its been twenty-five years since Ken Saro-Wiwa was hanged for defending the environment.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>de Beek to the rescue for the Netherlands</strong> - Finland beats France; Batshuayi brace for Belgium</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chennai Thursdays races cancelled</strong> - The stewards of Madras Race Club cancelled the second day races scheduled to be held on Thursday (Nov. 12) owing to the rain that made underfoot condi</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pucovski gets Test call up</strong> - Green, Abbott, Swepson and Neser also get the nod</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Champion Lewis Hamilton in pole position to land a bumper deal</strong> - A win in the Turkish Grand Prix this weekend will set up contract negotiations with Mercedes</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Belihu, Gemecu to defend titles</strong> - Elite field for Airtel Delhi half marathon to be run on Nov. 29</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Insertion of Sada Bainama clause will resolve stalemate: experts</strong> - Uncertainty over whether Legislature will be summoned or ordinance will be issued</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CM seeks report on CSP</strong> - Chief Minister Y.S. Jagan Mohan Reddy has directed officials to prepare a comprehensive report on the Contributory Pension Scheme (CPS), including the</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Endowments Department has become redundant: Somu Veerraju</strong> - He calls for complete overhaul of religious institutions</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Suicide pact: Salams mother-in-law given ₹25 lakh</strong> - The State government would support the next of kin of Abdul Salam, the autorickshaw driver who had committed suicide along with his wife and children</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Maharashtra Council polls: MVA faces its first real test</strong> - Coalition partners release names of candidates for December 1 elections</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Europe migrant crisis: Scores die in shipwreck off Libya - UN</strong> - The UN says nations must take decisive action to stem a “mounting loss of life in the Mediterranean”.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Belgian anaesthetist jailed for causing Brits death while drunk</strong> - Helga Wauters is found guilty of manslaughter over the death of British 28-year-old Xynthia Hawke.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>France honours six-year-old WW2 Resistance agent</strong> - Marcel Pinte was a French Resistance messenger, shot dead by accident in 1944.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>China Muslims: Volkswagen says no forced labour at Xinjiang plant</strong> - The car maker defends continued production in a Chinese region mired in allegations of rights abuses.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Viewpoint: Russia and Turkey - unlikely victors of Karabakh conflict</strong> - Alexander Gabuev argues that Russia and Turkey have extended their influence with the end of fighting.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>macOS 11.0 Big Sur: The Ars Technica review</strong> - Yes, you read that right—Mac OS X (or macOS 10?) is no more. - <a href="https://arstechnica.com/?p=1705785">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Todays best tech deals: iPad, Fitbit, Bluetooth speakers, and more</strong> - Dealmaster also has deals on the Apple Watch SE, AirPods Pro, and LG OLED TVs. - <a href="https://arstechnica.com/?p=1722777">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>YouTube and YouTube TV suffered a two-hour global outage last night</strong> - Some related services—such as YouTube TV—were also affected. - <a href="https://arstechnica.com/?p=1722843">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Judge dismisses Apples “theft” claims in Epic Games lawsuit</strong> - “You actually have to have facts,” Judge tells lawyers arguing for punitive damages. - <a href="https://arstechnica.com/?p=1722835">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DNS cache poisoning, the Internet attack from 2008, is back from the dead</strong> - A newly found side channel in a widely used protocol lets attackers spoof domains. - <a href="https://arstechnica.com/?p=1722675">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Greek and an Irishman were sitting in a Starbucks one day comparing their two cultures.</strong> - <!-- SC_OFF --></p>
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Over a double latte, the Greek mentions “We built the Pantheon, you may recall, along with the Temple of Apollo.”
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“Well, it was the Irish that discovered the Summer and Winter Solstices.”
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“But it was the Greeks who gave birth to advanced mathematics.”
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“Granted, but it was the Irish who built the first timepieces.”
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Knowing that hes about to deliver the coup de grace, the son of Athens points out with a note of finality: “Keep in mind that it was the ancient Greeks who invented the notion of sex as a pleasurable activity!”
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“True enough, replied the son of Erin”but it was the Irish who got women involved"
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<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/DillyOwea"> /u/DillyOwea </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jstlr0/a_greek_and_an_irishman_were_sitting_in_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jstlr0/a_greek_and_an_irishman_were_sitting_in_a/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The first Jewish President of the United States is elected</strong> - <!-- SC_OFF --></p>
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The night before the inauguration he calls his mother.
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“Mom, Id love for you to come visit for the inauguration and stay with me for a few days.”
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“Oh I dont know, airfare is so expensive these days.”
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“Mom, Ill fly you out on Air Force One!”
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“Oh, but you know, cab fare is ridiculous.”
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“Mom, the Presidential motorcade will drive you here.”
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“But accommodations, especially during the inau—”
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“MOM!! Ill put you in the Lincoln bedroom itself!!”
</p>
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She reluctantly agrees, hangs up and starts talking to her friend.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Who was that?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“My son.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
<em>gasp</em> “The doctor??”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“No, the other one.”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/DrButtsex_PHD"> /u/DrButtsex_PHD </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jsqne4/the_first_jewish_president_of_the_united_states/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jsqne4/the_first_jewish_president_of_the_united_states/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I angered 2 people by calling them hipsters</strong> - <!-- SC_OFF --></p>
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I found out the term is conjoined twins.
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Randomguy6282"> /u/Randomguy6282 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jsj271/i_angered_2_people_by_calling_them_hipsters/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jsj271/i_angered_2_people_by_calling_them_hipsters/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Greek, a Jew, and an Irishman are accidentally killed by a bus.</strong> - <!-- SC_OFF --></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A Greek, a Jew, and an Irishman are accidentally killed by a bus.<br/> An angel descends and tells them “Actually, theres been a mistake. It wasnt your time to die. We will let you come back to life, but you must promise to renounce your vices.”<br/> To the Irishman, the angel said, “Your vice is drinking too much. You can come back to life as long as you stop drinking. We will tempt and test you to make sure you abstain.” He agrees.<br/> To the Greek, the angel said, “You engage in perverted sexual practices. You can come back to life only if you remain celibate. We will test you to make sure you comply.” He agrees.<br/> To the Jew, the angel said, “Your vice is greed. You can come back to life only if you reform your avaricious ways. But you will be tested.” He agrees.<br/> As the three resurrected men are walking down the street, they pass a bar. The Irishman resists. They pass a second bar. He resists again. They pass a third bar, and the Irishman cant resist any longer - he runs toward the bar and instantly disappears in a puff of smoke.<br/> Frightened, the Greek and the Jew continue walking. The Jew spots a penny on the ground, and is able to resist picking it up. Then it turns into a quarter. Still he resists. Then it turns into a dollar. He wavers, but still resists.<br/> It turns into a five. Nope.<br/> It turns into a ten. Nope.<br/> It turns into a $20 bill.<br/> He bends over to pick it up, and both him and the Greek disappear.
</p>
</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Kalajasavakuy"> /u/Kalajasavakuy </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jsvl1c/a_greek_a_jew_and_an_irishman_are_accidentally/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jsvl1c/a_greek_a_jew_and_an_irishman_are_accidentally/">[comments]</a></span></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bad news: a message in German sent 110 years ago by homing pigeon was just found.</strong> - <!-- SC_OFF --></p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Worse news: it was an acceptance letter to art school.
</p>
</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Jokeminder42"> /u/Jokeminder42 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/jsech7/bad_news_a_message_in_german_sent_110_years_ago/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/jsech7/bad_news_a_message_in_german_sent_110_years_ago/">[comments]</a></span></p></li>
</ul>
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@ -13,9 +13,9 @@ Archive | Daily Reports
<li> <a href="#covid-19">Covid-19</a>
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<ul id="daily-dose-list"><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
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<h2 id="covid-19">Covid-19</h2>
<ul id="covid-19-list"><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
<ul id="covid-19-list"><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
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