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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li>**Spike-Induced Disturbances (SPAS*): An Analysis of Common Suspected Adverse Experiences Associated With Covid-19 Vaccines** -
<div>
This review/analysis gives a first impression of numerous adverse events related to Covid-19 vaccination, which have received little attention to date, are often unexplained, but are nevertheless very distressing. Frequently observed organ-related ADRs after Covid-19 vaccination were such of the nervous system, musculoskeletal system, gastrointestinal tract, and skin. The involvement of almost all organs in the side effect spectrum of Covid-19 vaccines demonstrates their systemic efficacy. As shown by the ADRs occurrence even after numerous days to weeks, the duration of spike production obviously lasts longer than claimed. The key role is played by the interaction between the spike subunit S1 and the membrane-bound enzyme ACE2, the receptor for SARS-CoV. Downregulation of ACE2 by spikes and following activation of RAAS can lead to numerous clinically relevant disorders, such as vasoconstriction, tissue ischemia, induction of proliferative processes, increased oxidative stress, inflammation, or coagulation disorders, as previously shown for cardiovascular reactions. It is proposed to use the collective term “SPAS” (in German: Spike ausgelöste Störungen) - spike induced disturbances for side effects based on this mode of action. The common mode of action and only slightly different frequencies of adverse events and fatal outcomes do not indicate any principal differences in adverse event profiles of the individual spike-based Covid-19 vaccines. A class-specific side effect profile can be assumed. Knowledge and awareness of the comprehensive adverse event profile of the novel Covid-19 vaccines and their potential dangerousness may improve vaccine safety.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/q94bn/" target="_blank">Spike-Induced Disturbances (SPAS*): An Analysis of Common Suspected Adverse Experiences Associated With Covid-19 Vaccines</a>
</div></li>
<li><strong>A cellular assay for spike/ACE2 fusion: quantification of fusion-inhibitory antibodies after COVID-19 and vaccination</strong> -
<div>
Not all antibodies against SARS-CoV-2 inhibit viral entry and hence infection. Neutralizing antibodies are more likely to reflect real immunity, however certain of these tests investigate protein/protein interaction rather than the fusion event. Viral and pseudoviral entry assays detect functionally active antibodies, however they are cumbersome and burdened by biosafety and standardization issues. We have developed a Spike/ACE2-dependant cell-to-cell fusion assay, based on a split luciferase. Hela cells stably transduced with Spike and a large fragment of luciferase were co-cultured with Hela cells transduced with ACE2 and the complementary small fragment of luciferase. Within 24h, cell fusion occured allowing the measurement of luminescence. Light emission was abolished in the absence of Spike and reduced in the presence of an inhibitor of Spike-processing proteases. Serum samples from COVID-19-negative, non-vaccinated individuals, or sera from patients at the moment of first symptoms did not lead to a significant reduction of fusion. In contrast, sera from COVID-19-positive patients as well as sera from vaccinated individuals reduced the fusion. In conclusion, we report a new method measuring fusion-inhibitory antibodies in serum, combining the advantage of a functional full Spike/ACE2 interaction with a high degree of standardization, easily allowing automation in a standard bio-safety environment.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.09.495433v1" target="_blank">A cellular assay for spike/ACE2 fusion: quantification of fusion-inhibitory antibodies after COVID-19 and vaccination</a>
</div></li>
<li><strong>Tracking infectious entry routes of SARS-CoV-2</strong> -
<div>
SARS-CoV-2 cell entry starts with membrane attachment and ends with spike-protein (S) catalyzed membrane fusion depending on two cleavage steps, one usually by furin in producing cells and the second by TMPRSS2 on target cells. Endosomal cathepsins can carry out both. Using real-time 3D single virion tracking, we show fusion and genome penetration requires virion exposure to an acidic milieu of pH 6.2-6.8, even when furin and TMPRSS2 cleavages have occurred. We detect the sequential steps of S1-fragment dissociation, fusion, and content release from the cell surface in TMPRRS2 overexpressing cells only when exposed to acidic pH. We define a key role of an acidic environment for successful infection, found in endosomal compartments and at the surface of TMPRSS2 expressing cells in the acidic milieu of the nasal cavity.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.09.495472v1" target="_blank">Tracking infectious entry routes of SARS-CoV-2</a>
</div></li>
<li><strong>Binding and unbinding pathways of peptide substrate on SARS-CoV-2 3CL protease</strong> -
<div>
Based on many crystal structures of ligand complexes, much study has been devoted to understanding the molecular recognition of SARS-CoV-2 3C-like protease (3CLpro), a potent drug target for COVID-19. In this research, to extend this present static view, we examined the kinetic process of binding/unbinding of an eight-residue substrate peptide to/from 3CLpro by evaluating the path ensemble with the weighted ensemble simulation. The path ensemble showed the mechanism of how a highly flexible peptide folded into the bound form. At the early stage, the dominant motion was the diffusion on the protein surface showing a broad distribution, whose centre was led into the cleft of the Chymotrypsin fold. We observed a definite sequential formation of the hydrogen bonds at the later stage occurring in the cleft, initiated between Glu166 (3CLpro) and P3_Val (peptide), followed by binding to the oxyanion hole and completed by the sequence-specific recognition at P1_Gln.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.08.495396v1" target="_blank">Binding and unbinding pathways of peptide substrate on SARS-CoV-2 3CL protease</a>
</div></li>
<li><strong>SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.</strong> -
<div>
Secretory immunoglobulin A (IgA) plays a crucial role in the mucosal immunity for preventing the invasion of the exogenous antigens, however, little has been understood about the neutralizing activity of serum IgA. Here, to examine the role of IgA antibodies against COVID-19 illnesses, we determined the neutralizing activity of serum/plasma IgG and IgA purified from previously SARS-CoV-2-infected and COVID-19 mRNA-vaccine-receiving individuals. We found that serum/plasma IgA possesses substantial but rather modest neutralizing activity against SARS-CoV-2 compared to IgG with no significant correlation with the disease severity. Neutralizing IgA and IgG antibodies achieved the greatest activity at approximately 25 and 35 days after symptom onset, respectively. However, neutralizing IgA activity quickly diminished and went down below the detection limit approximately 70 days after onset, while substantial IgG activity was observed till 200 days after onset. The total neutralizing activity in sera/plasmas of those with COVID-19 largely correlated with that in purified-IgG and purified-IgA and levels of anti-SARS-CoV-2-S1-binding IgG and anti-SARS-CoV-2-S1-binding IgA. In individuals who were previously infected with SARS-CoV-2 but had no detectable neutralizing IgA activity, a single dose of BNT162b2 or mRNA-1273 elicited potent serum/plasma neutralizing IgA activity but the second dose did not further strengthen the neutralization antibody response. The present data show that the systemic immune stimulation with natural infection and COVID-19 mRNA-vaccines elicit both SARS-CoV-2-specific neutralizing IgG and IgA response in serum, but the IgA response is modest and diminishes faster compared to IgG response.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.09.495422v1" target="_blank">SARS-CoV-2-neutralizing humoral IgA response occurs earlier but modest and diminishes faster compared to IgG response.</a>
</div></li>
<li><strong>ARF6 is an important host factor for SARS-CoV-2 infection in vitro</strong> -
<div>
SARS-CoV-2 is a newly emerged beta-coronavirus that enter cells via two routes, direct fusion at the plasma membrane or endocytosis followed by fusion with the late endosome/lysosome. While the viral receptor, ACE2, multiple entry factors, and the mechanism of fusion of the virus at the plasma membrane have been extensively investigated, viral entry via the endocytic pathway is less understood. By using a human hepatocarcinoma cell line, Huh-7, which is resistant to the antiviral action of the TMPRSS2 inhibitor camostat, we discovered that SARS-CoV-2 entry is not dependent on dynasore but dependent on cholesterol. ADP-ribosylation factor 6 (ARF6) has been described as a host factor for SARS-CoV2 replication and it is involved in the entry and infection of several pathogenic viruses. By CRISPR-Cas9 genetic deletion, we found that ARF6 is important for SARS-CoV-2 uptake and infection in Huh-7. In addition, the ARF6 inhibitor NAV-2729, and the ARF6 agonist AA147, showed a dose-responsive inhibition or enhancement of viral infection, respectively. Importantly, ARF6 inhibition reduced SARS-CoV-2 viral loads also in more physiologic models of infection: Calu-3 and kidney organoids, suggesting a role also in post-entry steps. Together, these experiments points to a ARF6 as a putative target to develop antiviral strategies against SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.09.495482v1" target="_blank">ARF6 is an important host factor for SARS-CoV-2 infection in vitro</a>
</div></li>
<li><strong>The Pandemic as a Portal: Reimagining Psychological Science as Truly Open and Inclusive</strong> -
<div>
Psychological science is at an inflection point: The COVID-19 pandemic has already begun to exacerbate inequalities that stem from our historically closed and exclusive culture. Meanwhile, reform efforts to change the future of our science are too narrow in focus to fully succeed. In this paper, we call on psychological scientists—focusing specifically on those who use quantitative methods in the United States as one context for such conversations—to begin reimagining our discipline as fundamentally open and inclusive. First, we discuss who our discipline was designed to serve and how this history produced the inequitable reward and support systems we see today. Second, we highlight how current institutional responses to address worsening inequalities are inadequate, as well as how our disciplinary perspective may both help and hinder our ability to craft effective solutions. Third, we take a hard look in the mirror at the disconnect between what we ostensibly value as a field and what we actually practice. Fourth and finally, we lead readers through a roadmap for reimagining psychological science in whatever roles and spaces they occupy, from an informal discussion group in a department to a formal strategic planning retreat at a scientific society.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/gdzue/" target="_blank">The Pandemic as a Portal: Reimagining Psychological Science as Truly Open and Inclusive</a>
</div></li>
<li><strong>Out-of-hospital Cardiac Arrest Before and During the COVID-19 Pandemic in the South Bronx</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Out-of-hospital cardiac arrest (OHCA) is a major health challenge; the impact of the COVID-19 pandemic on OHCA in the South Bronx is unknown. The aim of this study was to determine differences between return of spontaneous circulation(ROSC), witnessed arrest, bystander CPR and survival to discharge, prior to and during the COVID-19 pandemic to improve ROSC and survival. Methods: Single-center retrospective study of non-traumatic OHCA adult patients admitted to Lincoln Medical Center between 8/2019 to 6/2021, 3/2020 being the first established date of the COVID-19 pandemic in New York City. International Classification of Diseases (ICD) coding was used to identify cardiac arrests and collect information. Statistical analysis was performed using IBM-SPSS. Results: ROSC time pre COVID-19 was 26 minutes, during the COVID-19 pandemic it was 25 minutes 54 seconds. A significant difference in witnessed arrests in the pre COVID-19 period compared to the COVID-19 period (86% vs 55% p = 0.03). Bystander CPR occurred 36% of the time in the pre COVID-19 period contrasting to 19% during. Prior to the COVID-19 pandemic the overall survival to discharge in OHCA ROSC cases was 28.5% comparing to 29% during the pandemic. ROSC was 18 minutes among survivors during the pandemic, compared to 21 minutes in survivors prior to COVID (p = 0.2). Conclusion: There was a non-significant difference in ROSC, bystander CPR and survival to discharge in non-traumatic OHCA prior to and during the COVID-19 pandemic in the South Bronx. There was a significant difference in witnessed vs unwitnessed OHCA prior to and during the COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.08.22276169v1" target="_blank">Out-of-hospital Cardiac Arrest Before and During the COVID-19 Pandemic in the South Bronx</a>
</div></li>
<li><strong>Environmental circulation of adenovirus 40/41 and SARS-CoV-2 in the context of the emergence of acute hepatitis of unknown origin</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The recent surge of hepatitis of unknown origin in children is hypothesized to be caused by adenovirus 41 and/or SARS-CoV-2 infections. A relatively high proportion of patients testing positive for these viruses concomitantly with the development of acute hepatitis supports this hypothesis. To formally incriminate these viral infections as causative agents of hepatitis, both a plausible physiopathological pathway and supporting epidemiological dynamics in the community need demonstration. In this study, we measured the level of circulation of adenovirus 40/41 and SARS-CoV-2 in the general population of the city of Leuven in Belgium using wastewater monitoring between December 2020 and May 2022 and indoor air sampling in day care centers between November 2021 and May 2022. We also retrospectively analyzed medical records of 12.672 children attending a tertiary hospital draining the same region between January 2019 and April 2022. Our results demonstrate a recent but modest increase in hepatitis of unknown origin concomitant with a surge of circulating adenovirus 41 and SARS-CoV-2 in the general population, including in children under 5.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.08.22276091v1" target="_blank">Environmental circulation of adenovirus 40/41 and SARS-CoV-2 in the context of the emergence of acute hepatitis of unknown origin</a>
</div></li>
<li><strong>Validity of self-testing at home with rapid SARS-CoV-2 antibody detection by lateral flow immunoassay</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody lateral flow immunoassays (LFIA) can be carried out in the home and have been used as an affordable and practical approach to large-scale antibody prevalence studies. However, assay performance differs from that of high-throughput laboratory-based assays which can be highly sensitive. We explore LFIA performance under field conditions compared to laboratory-based ELISA and assess the potential of LFIAs to identify people who lack functional antibodies following infection or vaccination. Methods: Field evaluation of a self-administered LFIA test (Fortress, NI) among 3758 participants from the REal-time Assessment of Community Transmission-2 (REACT-2) study in England selected based on vaccination history and previous LFIA result to ensure a range of antibody titres. In July 2021, participants performed, at home, a self-administered LFIA on finger-prick blood, reported and submitted a photograph of the result, and provided a self-collected capillary blood sample (Tasso-SST) for serological assessment of IgG antibodies to the spike protein using the Roche Elecsys Anti-SARS-CoV-2 assay. We compared the self-administered and reported LFIA result to the quantitative Roche assay and checked the reading of the LFIA result with an automated image analysis (ALFA). In a subsample of 250 participants, we compared the results to live virus neutralisation. Results: Almost all participants (3593/3758, 95.6%) had been vaccinated or reported prior infection, with most having received one (862, 22.9%) or two (2430, 64.7%) COVID-19 vaccine doses. Overall, 2777/3758 (73.9%) were positive on self-reported LFIA, 2811/3457 (81.3%) positive by LFIA when ALFA-reported, and 3622/3758 (96.4%) positive on Roche anti-S (using the manufacturer reference standard threshold for positivity of 0.8 U ml-1). Live virus neutralisation was detected in 169 of 250 randomly selected samples (67.6%); 133/169 were positive with self-reported LFIA (sensitivity 78.7%; 95% CI 71.8, 84.6), 142/155 (91.6%; 86.1, 95.5) with ALFA, and 169 (100%; 97.8, 100.0) with Roche anti-S. There were 81 samples with no detectable virus neutralisation; 47/81 were negative with self-reported LFIA (specificity 58.0%; 95% CI 46.5, 68.9), 34/75 (45.3%; 33.8, 57.3) with ALFA, and 0/81 (0%; 0.0, 4.5) with Roche anti-S. All 250 samples remained positive with Roche anti-S when the threshold was increased to 1000U ml-1. Conclusions: Self-administered LFIA can provide insights into population patterns of infection and vaccine response, and sensitivity can be improved with automated reading of the result. The LFIA is less sensitive than a quantitative antibody test, but the positivity in LFIA correlates better than the quantitative ELISA with virus neutralisation.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.08.22276154v1" target="_blank">Validity of self-testing at home with rapid SARS-CoV-2 antibody detection by lateral flow immunoassay</a>
</div></li>
<li><strong>Seroprevalence of SARS-CoV-2 and risk factors in Bantul Regency, Yogyakarta, Indonesia</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
COVID-19 case counts in Indonesia inevitably underestimate the true cumulative incidence of infection due to limited barriers to testing accessibility and asymptomatic infections. Therefore, community-based serological data are essential for understanding the true prevalence of infections. This study aims to estimate the seroprevalence of SARS-CoV-2 infection and factors related to the seropositivity in Bantul Regency, Yogyakarta, Indonesia. A cross-sectional study involving 425 individuals in 40 clusters was conducted between March and April 2021. Participants were interviewed using an e-questionnaire developed in the Kobo toolbox to collect information on socio-demographic, COVID-19 suggestive symptoms, history of COVID-19 diagnosis and COVID-19 vaccination status. A venous blood sample was collected from each participant and tested for immunoglobulin G (Ig-G) SARS-CoV-2 antibody titers using the enzyme-linked immunosorbent assay (ELISA). Seroprevalence was 31.1% in the Bantul Regency: 34.2% in semi-urban and 29.9% in urban villages. However, there is no significant proportion difference between both areas. A significant difference was reported in the age group. Participants in the 55-64 age group demonstrated the highest seroprevalence (43.7%; p=0.00), with a higher risk compared to the other age group (aOR= 3.79; 95% CI, 1.46-9.85, p&lt;0.05). Seroprevalence in the unvaccinated participants was 29.9%. Family clusters accounted for 10.6% of the total seropositive cases. No significant difference was observed between individual preventive actions and their mobility with seropositivity status. This study observed a discrepancy with COVID-19 confirmed cumulative incidence data reported in the same period (11 out of 1000 population), indicating silent transmission may have occurred within the community. Higher seroprevalence in semi-urban areas rather than urban areas suggests a gap in health services access. Surveillance improvement through testing, tracing, and treatment, particularly in areas with lower access to health services, are necessary, along with more robust implementations of health protocols.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.07.22276128v1" target="_blank">Seroprevalence of SARS-CoV-2 and risk factors in Bantul Regency, Yogyakarta, Indonesia</a>
</div></li>
<li><strong>Estimating the within-person change in dental service access measures during the COVID-19 Pandemic</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: American adults delay dental care more than any other healthcare service. Unfortunately, the COVID-19 pandemic may have stalled efforts to address dental service delays. Early evidence has suggested substantial declines in dental service visits in the early phase of the pandemic, however our study is among the first to measure within-person changes from 2019 to 2020 and conduct subgroup analyses to examine if changing dental patterns were mediated by exposure to the pandemic, risk of adverse COVID-19 outcomes, or dental insurance. Methods: We analyzed a National Health Interview Survey panel of individuals initially surveyed in 2019, with subsequent follow up in 2020. The outcomes included dental service access measures and the interval of a most recent dental visit. By constructing a probability weighted linear regression model with fixed-effects, we estimated the average within-person change from 2019 to 2020. Robust standard errors were clustered within each respondent. Results: Overall, adults in 2020 were 4.6%-points less likely to visit the dentist compared to 2019 (p &lt; 0.001). Significantly higher declines were found in Northeast/West regions compared to Midwest/South. We find no evidence that declining dental services in 2020 were associated with more chronic diseases, older age, or lack of dental insurance coverage. Adults did not report more financial or non-financial access barriers to dental care in 2020 compared to 2019. Conclusions: The long-term effects of the COVID-19 pandemic on delayed dental care warrants continued monitoring as policymakers aim to mitigate the pandemic9s negative consequences on oral health equity.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.08.22276174v1" target="_blank">Estimating the within-person change in dental service access measures during the COVID-19 Pandemic</a>
</div></li>
<li><strong>Effects of Covid-19 Pandemic on Online Shopping Behavior in Iran</strong> -
<div>
Purpose - the main purpose of this study is to investigate the impact of Covid-19 pandemic on online shopping behavior in Iran. Design/methodology/approach - 484 customers of Digi Kala were selected by simple random sampling. The present study is applied objectively. The present study is a descriptive research in terms of how to collect data and it is a field research in terms of data collection. Structural equation modeling and SPSS 23 and SMARTPLS3 software were used to analyze the data. Findings - our results indicated that Covid-19 pandemic had a positive and significant effect on online shopping behavior in Iran. The level of health and economic fears during Covid-19 pandemic had a positive and significant effect on online shopping behavior in Iran. According to the moderating role of generational differences, Covid-19 pandemic and the level of health fears during the pandemic had a positive and significant effect on online shopping behavior in Iran. Nevertheless, the level of economic fears during Covid-19 pandemic had no significant effect on online shopping behavior in Iran according to the moderating role of generational differences. Originality/value - this work provides a guidance for the researchers and academicians in the field of marketing. Correspondingly, retailers and marketers should train themselves to survive during the global pandemics, and learn innovative approaches to supply the needs according to the changes in customers shopping behavior.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/f9wng/" target="_blank">Effects of Covid-19 Pandemic on Online Shopping Behavior in Iran</a>
</div></li>
<li><strong>Efficient reconciliation of genomic datasets of high similarity</strong> -
<div>
We apply Invertible Bloom Lookup Tables (IBLTs) to comparison of k-mer sets originated from large DNA sequence datasets. We show that for similar datasets, IBLTs provide a more space-efficient and, at the same time, more accurate method for estimating Jaccard similarity of underlying k-mer sets, compared to MinHash which is a go-to sketching technique for efficient pairwise similarity estimation. This is achieved by combining IBLTs with k-mer sampling based on syncmers, which constitute a context-independent alternative to minimizers and provide an unbiased estimator of Jaccard similarity. A key property of our method is that involved data structures take space proportional to the difference of k-mer sets and are independent of the size of sets themselves. As another application, we show how our ideas can be applied in order to efficiently compute (an approximation of) k-mers that differ between two datasets, still using a space only proportional to their number. We experimentally illustrate our results on both simulated and real data (SARS-CoV-2 and Streptococcus Pneumoniae genomes).
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.07.495186v1" target="_blank">Efficient reconciliation of genomic datasets of high similarity</a>
</div></li>
<li><strong>Microbial Risk Score for Capturing Microbial Characteristics, Integrating Multi-omics Data, and Predicting Disease Risk</strong> -
<div>
Background: With the rapid accumulation of microbiome-wide association studies, a great amount of microbiome data are available to study the microbiome’s role in human disease and advance the microbiome’s potential use for disease prediction. However, the unique features of microbiome data hinder its utility for disease prediction. Methods: Motivated from the polygenic risk score framework, we propose a microbial risk score (MRS) framework to aggregate the complicated microbial profile into a summarized risk score that can be used to measure and predict disease susceptibility. Specifically, the MRS algorithm involves two steps: 1) identifying a sub-community consisting of the signature microbial taxa associated with disease, and 2) integrating the identified microbial taxa into a continuous score. The first step is carried out using the existing sophisticated microbial association tests and pruning and thresholding method in the discovery samples. The second step constructs a community-based MRS by calculating alpha diversity on the identified sub-community in the validation samples. Moreover, we propose a multi-omics data integration method by jointly modeling the proposed MRS and other risk scores constructed from other omics data in disease prediction. Results: Through three comprehensive real data analyses using the NYU Langone Health COVID-19 cohort, the gut microbiome health index (GMHI) multi-study cohort, and a large type 1 diabetes cohort separately, we exhibit and evaluate the utility of the proposed MRS framework for disease prediction and multi-omics data integration. In addition, the disease-specific MRSs for colorectal adenoma, colorectal cancer, Crohn’s disease, and rheumatoid arthritis based on the relative abundances of 5, 6, 12, and 6 microbial taxa respectively are created and validated using the GMHI multi-study cohort. Especially, Crohn’s disease MRS achieves AUCs of 0.88 ([0.85-0.91]) and 0.86 ([0.78-0.95]) in the discovery and validation cohorts, respectively. Conclusions: The proposed MRS framework sheds light on the utility of the microbiome data for disease prediction and multi-omics integration, and provides great potential in understanding the microbiome’s role in disease diagnosis and prognosis.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.07.495127v1" target="_blank">Microbial Risk Score for Capturing Microbial Characteristics, Integrating Multi-omics Data, and Predicting Disease Risk</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase I Clinical Trial of GEN2-Recombinant COVID-19 Vaccine (CHO Cells) in Healthy People Aged 18 and Above</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Biological: Experimental Vaccine 1;   Biological: Experimental Vaccine 2;   Biological: Experimental Vaccine 3;   Biological: placebo<br/><b>Sponsors</b>:   National Vaccine and Serum Institute, China;   Lanzhou Institute of Biological Products Co., Ltd;   Beijing Institute of Biological Products Co Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Algorithm Treatment at Home</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Recommended treatment schedule;   Drug: Usual care<br/><b>Sponsor</b>:   Mario Negri Institute for Pharmacological Research<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eucalyptus Oil as Adjuvant Therapy for Coronavirus Disease 19 (COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Eucalyptus Oil;   Drug: Standard COVID medication<br/><b>Sponsors</b>:   Hasanuddin University;   Ministry of Agriculture, Republic of Indonesia<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19</strong> - <b>Condition</b>:   Asymptomatic COVID-19<br/><b>Interventions</b>:   Drug: Cepharanthine;   Drug: Placebo<br/><b>Sponsors</b>:   Shanghai Jiao Tong University School of Medicine;   YUNNAN BAIYAO GROUP CO.,LTD<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Epidemiological Monitoring of COVID-19 Patients Hospitalized on Reunion Island</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: telephone interview 24 months after hospitalization for Covid-19<br/><b>Sponsor</b>:   Centre Hospitalier Universitaire de la Réunion<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Real-time Quaking-Induced Conversion (RT-QuIC)<br/><b>Sponsor</b>:   Medical University Innsbruck<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Randomized, Single-blinded, Multicenter Trial Comparing the Immune Response to a 2nd Booster Dose of COVID-19 mRNA Vaccine (Pfizer-BioNTech) or Sanofi /GSK B.1.351 Adjuvanted Vaccine in Adults</strong> - <b>Condition</b>:   COVID-19 Vaccines<br/><b>Interventions</b>:   Biological: 2nd booster with Comirnaty® (Pfizer-BioNTech);   Biological: CoV2 preS dTM adjuvanted vaccine (B.1.351), Sanofi/GSK<br/><b>Sponsors</b>:   Assistance Publique - Hôpitaux de Paris;   IREIVAC/COVIREIVAC Network<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety of a Third Dose of COVID-19 Vaccine(Vero Cell), Inactivated in the Elderly</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: COVID-19 Vaccine (Vero cell), Inactivated<br/><b>Sponsor</b>:   Sinovac Life Sciences Co., Ltd.<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy, Safety and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)(Recov)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant two-component COVID-19 vaccine (CHO cell);   Biological: Placebo<br/><b>Sponsor</b>:   Jiangsu Rec-Biotechnology Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety Study of Booster Vaccine With the COVID-19 Vaccine (Vero Cell), Inactivated, Omicron Strain</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: COVID-19 Vaccine (Vero Cell), Inactivated, Omicron Strain<br/><b>Sponsor</b>:   Sinovac Biotech (Hong Kong) Limited<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 1a Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: RQ3013;   Biological: Comirnaty<br/><b>Sponsors</b>:   Walvax Biotechnology Co., Ltd.;   Shanghai RNACure Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 1b Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: RQ3013;   Biological: Comirnaty<br/><b>Sponsors</b>:   Walvax Biotechnology Co., Ltd.;   Shanghai RNACure Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Plerixafor in Acute Respiratory Distress Syndrome Related to COVID-19 (Phase IIb)</strong> - <b>Conditions</b>:   COVID-19 Acute Respiratory Distress Syndrome;   COVID-19<br/><b>Interventions</b>:   Drug: Plerixafor 20 MG/ML [Mozobil];   Other: Placebo<br/><b>Sponsor</b>:   4Living Biotech<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Telerehabilitative Aerobic and Relaxation Exercises Patients With Type 2 Diabetes With and Without COVID-19</strong> - <b>Conditions</b>:   COVID-19;   Type 2 Diabetes Mellitus<br/><b>Intervention</b>:   Other: Aerobic and Relaxation Exercises<br/><b>Sponsor</b>:   Bozyaka Training and Research Hospital<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Long Haul COVID Rehabilitation &amp; Recovery Research Program</strong> - <b>Condition</b>:   Long Haul COVID or Post Acute Sequella of COVID - PASC (U09.9)<br/><b>Intervention</b>:   Other: Virtual vs On Site Pulmonary Rehabilitation<br/><b>Sponsor</b>:   Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus Disease 2019 Vaccine Booster Effects Are Seen in Human Milk Antibody Response</strong> - Infants remain at high risk for severe coronavirus disease 2019 (COVID-19). Human milk contains high levels of protective SARS CoV-2 specific antibodies post-infection and primary vaccine series, but levels decline over time. We hypothesized that the COVID-19 booster vaccine augment antibody production and the protection afforded to human milk-fed infants. We prospectively enrolled pregnant or lactating mothers planning to receive COVID-19 vaccination. We measured human milk IgG, IgA, and IgM…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Modeling and Simulation Analysis of Antimicrobial Photodynamic Therapy Potential for Control of COVID-19</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter the host cells by binding the viral surface spike glycoprotein (SG) to angiotensin-converting enzyme 2. Since antiviral photodynamic therapy (aPDT) has been described as a new method for inhibiting viral infections, it is important to evaluate whether it can be used as a photoactivated disinfectant to control COVID-19. In this in silico study, SARS-CoV-2-SG was selected as a novel target for curcumin as a photosensitizer…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein</strong> - Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. Therapy for ITP relies on competing and inhibiting the autoantibody binding and destruction (intravenous immunoglobulin and anti-D immunoglobulin and spleen tyrosine kinase (Syk) inhibitor fostamatinib), augmenting platelet production…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Development and Validation of an HPLC-UV Method for the Quantification of 4’-Hydroxydiclofenac Using Salicylic Acid: Future Applications for Measurement of In Vitro Drug-Drug Interaction in Rat Liver Microsomes</strong> - Salicylic acid is a key compound in nonsteroidal anti-inflammatory drugs that has been recently used for preventing the risk of hospitalization and death among COVID-19 patients and in preventing colorectal cancer (CRC) by suppressing two key proteins. Understanding drug-drug interaction pathways prevent the occurrence of adverse drug reactions in clinical trials. Drug-drug interactions can result in the variation of the pharmacodynamics and pharmacokinetic of the drug. Inhibition of the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Isolation and Characterization of Werneria Chromene and Dihydroxyacidissimol from <em>Burkillanthus</em>&amp;amp;nbsp;<em>malaccensis</em> (Ridl.) Swingle</strong> - The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthusmalaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthusmalaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bark, wood, pericarps, and endocarps were tested against bacteria by broth microdilution assay and their antibiotic-potentiating activities….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production</strong> - Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This infectious disease has emerged in 2019. The COVID-19-associated pandemic has considerably affected the way of life and the economy in the world. It is consequently crucial to find solutions allowing remedying or alleviating the effects of this infectious disease. Natural products have been in perpetual application from immemorial time given that they are…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Third and Fourth mRNA-Based Booster Vaccinations on SARS-CoV-2 Neutralizing Antibody Titer Formation, Risk Factors for Non-Response, and Outcome after SARS-CoV-2 Omicron Breakthrough Infections in Patients on Chronic Hemodialysis: A Prospective Multicenter Cohort Study</strong> - CONCLUSIONS: Third and fourth mRNA-based booster vaccinations resulted in higher and longer lasting SARS-CoV-2 antibody levels as compared to after two dosages. The presence of immunosuppressive medication and repeat vaccinations are major potentially modifiable measures to increase antibody levels in non-or low-responders. Breakthrough infections with SARS-CoV-2 Omicron were associated with prolonged viral shedding but clinically mild disease courses.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of Respiratory Syncytial Virus Infection by Small Non-Coding RNA Fragments</strong> - Respiratory syncytial virus (RSV) causes acute lower respiratory tract infection in infants, immunocompromised individuals and the elderly. As the only current specific treatment options for RSV are monoclonal antibodies, there is a need for efficacious antiviral treatments against RSV to be developed. We have previously shown that a group of synthetic non-coding single-stranded DNA oligonucleotides with lengths of 25-40 nucleotides can inhibit RSV infection in vitro and in vivo. Based on this,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Improvement in Quality of Life through Self-Management of Mild Symptoms during the COVID-19 Pandemic: A Prospective Cohort Study</strong> - The COVID-19 pandemic has inhibited people’s help-seeking behaviors (HSBs). In particular, older people in rural communities experienced limited access to medical care, which negatively affected their quality of life (QOL). Within HSB, self-management of mild symptoms may mitigate the difficulties experienced by older people in rural communities. However, few studies have examined the relationship between self-management and QOL. Therefore, we conducted a prospective cohort study to clarify this…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 Neutralizing Antibodies Kinetics Postvaccination in Cancer Patients under Treatment with Immune Checkpoint Inhibition</strong> - Considering that COVID-19 could adversely affect cancer patients, several countries have prioritized this highly susceptible population for vaccination. Thus, rapidly generating evidence on the efficacy of SARS-CoV-2 vaccination in the subset of patients with cancer under active therapy is of paramount importance. From this perspective, we launched the present prospective observational study to comprehensively address the longitudinal dynamics of immunogenicity of both messenger RNA (mRNA) and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein</strong> - CONCLUSION: This study is the first to prove that rACE2 plays a protective role against SARS-CoV-2 spike RBD protein-aggravated LPS-induced ALI in an animal model and illustrate the mechanism by which the ACE2-AngII-AT(1)R-NOX1/2 axis might contribute to SARS-CoV-2-induced ALI.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In Vivo Visualization and Quantification of Neutrophil Elastase in Lungs of COVID-19 Patients - A First-In-Human Positron Emission Tomography Study with <sup>11</sup>C-GW457427</strong> - COVID-19 can cause life-threatening lung-inflammation that is suggested to be mediated by neutrophils, whose effector mechanisms in COVID-19 is inexplicit. The aim of the present work is to evaluate a novel PET tracer for neutrophil elastase in COVID-19 patients and healthy controls. METHODS: In this open-label, First-In-Man study, four patients with hypoxia due to COVID-19 and two healthy controls were investigated with positron emission tomography (PET) using the new selective and specific…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Polypyridyl ruthenium complexes as bifunctional TAR RNA binders and HIV-1 reverse transcriptase inhibitors</strong> - Inhibitors of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase are central to anti-HIV therapy. Most of their targets are enzymes, while very few could bind to viral RNA. Here we designed four new polypyridyl Ru(II) complexes, which could bind HIV-1 TAR RNA tightly and selectively by molecular recognition of hydrogen bonds, further stabilize the Ru(II)-RNA bound system by electrostatic attraction, and efficiently inhibit the Moloney murine leukemia virus (M-MuLV) and HIV-1…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The interaction between anti-PF4 antibodies and anticoagulants in vaccine-induced thrombotic thrombocytopenia</strong> - Life-threatening thrombotic events at unusual sites have been reported after vector-based vaccinations against severe acute respiratory syndrome coronavirus 2. This phenomenon is now termed vaccine-induced immune thrombotic thrombocytopenia (VITT). The pathophysiology of VITT is similar to that of heparin-induced thrombocytopenia (HIT) and is associated with platelet-activating antibodies (Abs) against platelet factor 4 (PF4). Therefore, current guidelines suggest nonheparin anticoagulants to…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Investigating the Link between Alpha-1 Antitrypsin and Human Neutrophil Elastase in Bronchoalveolar Lavage Fluid of COVID-19 Patients</strong> - Neutrophils play a pathogenic role in COVID-19 by releasing Neutrophils Extracellular Traps (NETs) or human neutrophil elastase (HNE). Given that HNE is inhibited by α1-antitrypsin (AAT), we aimed to assess the content of HNE, α1-antitrypsin (AAT) and HNE-AAT complexes (the AAT/HNE balance) in 33 bronchoalveolar lavage fluid (BALf) samples from COVID-19 patients. These samples were submitted for Gel-Electrophoresis, Western Blot and ELISA, and proteins (bound to AAT or HNE) were identified by…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Without Mark Meadows, January 6th Might Never Have Happened</strong> - Trump’s fourth and final White House chief of staff served as the “matador” for the former President’s election lies. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/mark-meadows-was-trumps-matador-for-his-fake-election-lies">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can Researchers Show That Threat Assessment Stops Mass Shootings?</strong> - Threat assessment aims to prevent attacks like the Uvalde school shooting. Studies suggest that it’s effective in other ways. - <a href="https://www.newyorker.com/news/annals-of-inquiry/can-researchers-show-that-threat-assessment-stops-mass-shootings">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why San Francisco Fired Chesa Boudin</strong> - Does the district attorney’s recall reveal the limitations of progressive criminal-justice reform? - <a href="https://www.newyorker.com/news/the-political-scene/why-san-francisco-fired-chesa-boudin">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dishonor, Trump’s and His Party’s, Is the Real January 6th Takeaway</strong> - Liz Cheney, defying the G.O.P., offered a searing indictment of the former President at Thursday’s hearing. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/dishonor-trumps-and-his-partys-is-the-real-january-6th-takeaway">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Are Crossover Efforts to Defeat Extreme Republicans Gaining Ground?</strong> - Utah Democrats are taking extraordinary action, and other groups are pursuing new strategies to safeguard democratic norms. - <a href="https://www.newyorker.com/news/daily-comment/are-crossover-efforts-to-defeat-extreme-republicans-gaining-ground">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>What happens if you clone Jurassic Park</strong> -
<figure>
<img alt="The snout of a large dinosaur is visible above the windows of a flipped-over car containing Laura Dern and DeWanda Wise." src="https://cdn.vox-cdn.com/thumbor/hl1eEftr5h6AQ2Pd67M87377wew=/667x0:6000x4000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70962829/2512_D092_00556_0570RV2_COMP.0.jpeg"/>
<figcaption>
Kayla Watts (DeWanda Wise) and Dr. Ellie Sattler (Laura Dern) try to hide from a Giganotosaurus in <em>Jurassic World Dominion</em>. | John Wilson/Universal Pictures and Amblin Entertainment
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Jurassic World Dominion is the latest nostalgic reboot that will make a billion dollars, no matter what critics say.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="H35The">
It’s hard to know exactly when I first felt the space-time continuum warp under me during <em>Jurassic World Dominion</em>, but I’m sure it happened under the streets of Malta. The island nation has become a hot spot for the trafficking of dinosaurs — a big problem in this cinematic universe. Thanks to the missteps of a few overambitious scientists, all kinds of ancient reptiles have taken over the planet. But that’s not why Owen Grady (Chris Pratt) and Clare Dearing (Bryce Dallas Howard) have found themselves in a gritty Mediterranean sewer. The heroes are there to rescue their daughter: a young human clone.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vPEzFo">
Written out, all of that sounds fairly original and even compelling. But on the screen, it amounts to an uncanny collision of tropes pulled from the summer blockbuster franchises of the past few decades. A walk through the underground dinosaur market may as well be a visit to <a href="https://www.youtube.com/watch?v=IK_iw5Yps2M">an outer world in a <em>Star Wars</em> movie</a>, and then there’s a parkour-laden chase through sunburnt streets that feels distinctly similar to a certain chase scene <a href="https://www.youtube.com/watch?v=89aTFgtsXX0">in the James Bond film <em>Quantum of Solace</em></a>. This is followed by Chris Pratt somehow driving a motorcycle onto a moving plane in a stunt that I’m pretty sure I saw Tom Cruise do <a href="https://www.youtube.com/watch?v=elpUGB9Ap1Y">in one of the <em>Mission: Impossible </em>sequels</a>. Meanwhile, kind of in the background, the stars of <em>Jurassic Park</em> are busy reliving the plot of the original movie.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qErDTn">
Speaking of the stars, even if you haven’t seen the past few movies in the Jurassic universe, <em>Dominion</em> is worth a look if only to see Laura Dern, Sam Neill, and Jeff Goldblum all on the same screen for the first time since the 1994 film. That’s the one directed by Steven Spielberg featuring a legendary soundtrack by John Williams, all based on Michael Crichton’s eponymous novel. <em>Jurassic Park</em> offered a look at a world in which we could use technology to create clones of extinct species for theme park purposes. The concept seemed absurd at the time, but with the arrival of the final movie in the second Jurassic trilogy, <a href="https://www.bbc.com/future/article/20220322-why-dont-we-hear-about-cloning-anymore">people are cloning their pets</a>, and <a href="https://www.nytimes.com/2021/09/13/science/colossal-woolly-mammoth-DNA.html">bringing back the woolly mammoth</a> seems like it may be within reach.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RRfjh7">
So why not clone <em>Jurassic Park</em>? That’s not exactly what <em>Jurassic World Dominion</em> sets out to do. Rather, <a href="https://www.vox.com/culture/22890147/scream-5-matrix-4-legacyquel">like <em>The Matrix Resurrections</em> and <em>Scream</em> before it</a>, the movie creates a new chapter in a decades-old franchise by splicing together a new plot with a reimagined version of the original. This means finding a way to insert the old dinosaur enthusiasts (Dern, Neill, and Goldblum) into a story that revolves around the contemporary versions of their old characters (Howard, Pratt, and … well there’s no substitute for Jeff Goldblum in any world). Fans love this sort of thing, and it’s uniquely appropriate for this universe. After all, Michael Crichton had never written a sequel until the <em>Jurassic Park</em> movie was such a hit that fans demanded a sequel, and <a href="https://www.michaelcrichton.com/the-lost-world/">they got one</a>. That dynamic is not so different from what we’re seeing with movies nowadays.
</p>
<figure class="e-image">
<img alt="The actors in the movie Jurassic Park Dominion look in awe at something above them." src="https://cdn.vox-cdn.com/thumbor/L8hs0IZnuslrSqkwu5kLXI3W_GI=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23618175/2512_D091_00175R.jpeg"/> <cite>John Wilson/Universal Pictures and Amblin Entertainment</cite>
<figcaption>
<em>Jurassic Park Dominion</em> brings together the actors from the original<em> Jurassic Park</em>, the actors from the sequels, and some new faces.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ViWbSt">
Welcome to the age of nostalgic reboots. The summer blockbuster as we once knew it — typically an action-packed, star-studded, roller-coaster ride on screen — has been replaced by a recycled version of all the action-packed, star-studded, roller-coaster rides from years past. In the case of <em>Jurassic World Dominion</em>, it’s not only intellectual property from 30 years ago but also a little dose of all the money-making ideas that have hit the big screen since then. The only thing that’s more likely than nostalgic reboots to get a big budget and huge distribution deals is superhero movies, because studios also already know the template and audiences know what they’re going to get if they spend $12 on a ticket. Good luck finding an indie drama at your local theater. <em>Jurassic Park Dominion</em> and <em>Top Gun: Maverick</em> are probably playing on all eight screens.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4B26M0">
Reboots, though, can be fun. <em>Jurassic World Dominion</em> is a blast, especially if you want to remember how incredible the original was. The new film offers up parallel plotlines that eventually intersect. One picks up right where <em>Jurassic Park: Fallen Kingdom</em> left off and focuses on Grady and Dearing, whose adopted daughter Maisie Lockwood (Isabella Sermon) is abducted by dinosaur poachers early in the movie. The other follows Ellie Sattler (Laura Dern) as she rescues captured dinosaurs, only to discover that a breed of giant, prehistoric locusts is multiplying and eating the world’s food supply. But, Sattler learns, the locusts aren’t eating the crops planted with seeds made by a company named Biosys, so she goes to visit fellow paleontologist Alan Grant (Sam Neill) and talks him into taking a trip to Biosys headquarters, where their old friend Ian Malcolm (Jeff Goldblum) is working as a philosopher in residence.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KORslj">
Did I mention that dinosaurs have taken over the planet? This surprised me, too. I did remember some dinosaurs escaping into the wild at the end of <em>Fallen Kingdom</em>, but what we see in <em>Dominion</em> is truly astounding. The movie opens with a news segment from Now This about how dinosaurs are wreaking havoc all over our built environment. There are pterosaurs nesting on top of the World Trade Center! (Now This and Vox share a parent company, Vox Media.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gob2PE">
So unlike all previous <em>Jurassic Park</em> movies, there is no island from which the main characters will ultimately need to escape. After all, there are now dinosaurs all over the world, there’s no point in trying to outrun them. The place where the two plotlines intersect, Biosys HQ, is a different sort of island. It’s where the company is doing all of its experiments on the dinosaurs, which are all contained in this massive compound somewhere in northern Italy’s Dolomite mountains.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/7ljOS2v4bPBND8N19JqGppwZdyg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23618428/2512_D075_00653R_CROP.jpeg"/> <cite>John Wilson/Universal Pictures and Amblin Entertainment</cite>
<figcaption>
Alan Grant (Sam Neill) learns to train raptors just like his <em>Jurassic World</em> counterpart Owen Grady (Chris Pratt). And Maisie Lockwood (Isabella Sermon) is a clone, just like the raptors.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wb2wKu">
If the name Biosys sounds familiar, by the way, congratulations: you’re a <em>Jurassic Park</em> superfan. Biosys is the company responsible for the inciting incident in the 1994 film, the one that involved Dennis Nedry (Wayne Knight) attempting to steal the embryos of 15 dinosaur species so that Biosys could breed its own. The main villain in <em>Jurassic Park Dominion</em> is Lewis Dodgson (Campbell Scott), the character who very briefly appeared in the original movie (played by Cameron Thor that time) — he was on screen just long enough to give Nedry a can of Barbasol that had been modified to store dinosaur embryos. Dodgson’s chief scientist, you’ll learn, is Dr. Henry Wu (B.D. Wong), the same guy who developed the DNA-splicing technique that made it possible to bring dinosaurs back to life back in the 1994 film. Don’t worry, these details will come in handy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="93SD7i">
Once everybody’s at the Biosys compound, things heat up. The legacy cast goes about its mission to save the world from the giant locusts, while Grady and Dearing from the <em>Jurassic World</em> crew try to find their adopted clone daughter. We even get to meet a couple of new characters: reformed poacher Kayla Watts (DeWanda Wise) and Biosys handler Ramsay Cole (Mamoudou Athie), who bring some diversity to what has historically been an almost all-white cast. The last hour of the film is otherwise dedicated to bringing down big bad Dodgson, who bears a striking resemblance to Tim Cook, and packing in references to the classic <em>Jurassic Park</em>. It’s got it all: Malcolm <a href="https://www.youtube.com/watch?v=v5Co3A3fLBo">distracting a T. rex with a torch</a>, an escape from <a href="https://www.youtube.com/watch?v=8QCPRn55K0I">an upside-down SUV with a T. rex on top</a>, more than one <a href="https://www.youtube.com/watch?v=FtCslvCjZEY">battle between a T. rex and a dinosaur</a> that’s supposed to be bigger and meaner than the T. rex. Everyone knows, though, this is <em>Jurassic Park</em>: The T. rex will win, and she will roar at the lightning-filled sky.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FLIN5y">
All of this points to the central theme the Jurassic Park universe has always explored: the tension between man, technology, and nature. And while earlier installments lean heavily on a message about humans’ habit of tinkering with biodiversity, director Colin Trevorrow clearly wants you to think that <em>Dominion</em> is a climate change story. The prehistoric locust plague started with Dr. Wu manipulating the insect’s DNA, setting off a chain reaction that threatens to leave the planet barren, and at one point, the locusts literally rain down fire from above. If Drs. Sattler, Grant, and Malcolm don’t intervene, the world might burn, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eKNOC3">
But when you’re sitting in the audience, you’re probably not going to be thinking about climate change or biodiversity much at all. You’ll be too busy thinking about how much you love <em>Jurassic Park</em>. But you might not be able to reconcile your love of the original with the struggle to make the new trilogy, which was never quite as powerful as the original. Steven Spielberg has an executive producer credit on <em>Dominion</em>, but the most we really see of his work are references to other Spielberg movies.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/UfaQkzvUgeee8PI-HR_KHRX4ZcA=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23618431/2512_D053_00386R.jpeg"/> <cite>John Wilson/Universal Pictures and Amblin Entertainment</cite>
<figcaption>
Ian Malcom (Jeff Goldblum) looks svelte as ever, and the film’s villain, Lewis Dodgson (Campbell Scott), bears a slight resemblance to Apple CEO Tim Cook.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I5HQ5C">
You could almost separate <em>Jurassic Park Dominion</em>’s two competing storylines into their own movies, but neither plot is all that interesting. The primary one, starring Chris Pratt and Bryce Dallas Howard, is derivative and inevitably sort of dull, as it amounts to a couple of parents trying to find a lost child. The nostalgic one, starring the original Jurassic Park cast, feels like a cheap but extremely familiar trick: take an old fan favorite, mix up some details, hire the same actors, and make it into a new movie that lots of people will buy tickets to go see. It’s the same thing you’ll see in <em>Top Gun: Maverick</em>, and we saw a version of it last year in <em>Spider-Man: No Way Home</em>. The formula works. The <em>Top Gun</em> reboot <a href="https://www.reuters.com/lifestyle/box-office-top-gun-maverick-scores-86-million-massive-second-weekend-2022-06-05/">made over $250 million in its first two weekends</a>. The <em>Spider-Man</em> that features all of the old cinematic Spider-Mans <a href="https://variety.com/2022/film/news/spider-man-no-way-home-avatar-box-office-record-1235180474/">made nearly $2 billion at the box office</a>. Industry insiders are already saying <em>Jurassic Park Dominion</em> <a href="https://www.thewrap.com/jurassic-world-dominion-box-office-preview/">will be the next billion-dollar hit</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="scJIui">
There’s nothing wrong with a good nostalgic reboot. Reboots and remakes have been around as long as movies themselves. Heck, there have been at least four versions of <em>A Star Is Born</em> made over the course of a century! What’s a bit worrisome, however, is that if the only movies Hollywood wants to make are reboots of dependably successful franchises — and superhero movies, of course — that’s a lot of talent and money that’s not going into making entirely new features for theaters. As my colleague Peter Kafka <a href="https://www.vox.com/recode/2022/4/13/23022908/movies-theaters-future-peter-kafka">recently argued</a>, the future of movies looks pretty bleak in a world where studios only want guaranteed success at the box office and everything else gets relegated to streaming services.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GkmRJl">
Industry trends aside, <em>Jurassic World Dominion</em> is an awe-inspiring mess of a movie. It’s full of plot holes masquerading as scientific miracles. It feels like a pastiche of Steven Spielberg’s biggest hits — seriously, there are several scenes that may as well be in the next <em>Indiana Jones</em> sequel — and it’s hilarious. It’s 150-minutes of dinosaurs, both CGI and animatronic, that will thrill the kids. It’s loud.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vJmanM">
I’ll probably see it again next weekend. I’ve already seen <em>Top Gun: Maverick</em>, and there’s not much else playing.
</p></li>
<li><strong>“Miracles sometimes happen”: The Senate hasn’t given up on gun control — yet</strong> -
<figure>
<img alt="A white man in a blue suit stands amid a crowd of people with signs, with the US Capitol in the background." src="https://cdn.vox-cdn.com/thumbor/6Y-kUFLrntq3b5dO-S3W4dy_olQ=/549x0:4937x3291/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70962737/1241180269.0.jpg"/>
<figcaption>
Sen. Chris Murphy (D-CT) prepares to speak during the Moms Demand Action Gun Violence Rally on June 8, 2022, in Washington, DC. | Nathan Howard/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Where things stand on Senate gun control talks so far.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nFS531">
<a href="https://www.vox.com/2022/5/27/23143626/congress-gun-control-red-flag-laws-background-checks">A bipartisan group of senators</a> hoped to unveil a gun control deal on Friday, in the wake of a string of mass shootings, <a href="https://www.vox.com/policy-and-politics/23140441/uvalde-shooting-robb-elementary-school-texas">including those in Uvalde, Texas</a>, and <a href="https://www.vox.com/policy-and-politics/2022/5/17/23104692/buffalo-shooting-red-flag-gun-new-york">Buffalo, New York.</a> They don’t have one yet, but negotiators are still cautiously optimistic about getting an agreement in the coming days.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9a7ea7">
“It’ll be a miracle if we get a framework agreement, never mind a final bill,” Sen. Chris Murphy (D-CT) told reporters on Thursday. “But miracles sometimes happen!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v2nVDD">
Initially, lawmakers had hoped to reach an agreement by the end of this week, but as with many things in Congress, that deadline has slipped. Despite this delay, those leading the talks — including Murphy and Sen. John Cornyn (R-TX) — remained bullish on a possible agreement.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yjGpQA">
“This is a town where it’s fashionable to be pessimistic, so for my colleagues to be optimistic suggests there’s really cause for optimism,” Sen. Todd Young (R-IN), the former head of the Republican Senatorial Campaign Committee, told Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tvTqlM">
Any bipartisan deal — even an incremental one — would be significant given how enduring the logjam on gun control has been.<strong> </strong><a href="https://www.washingtonpost.com/nation/2022/06/02/mass-shootings-in-2022/">While mass shootings have increased in the US</a> in recent years, Congress has been unable to find any meaningful compromise on the issue for more than a decade. A deal would show the public that Congress can actually make progress on gun control, and, more importantly, any compromise could open the door to more ambitious policies down the line.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FojV6J">
“Success often begets success,” Sen. Tim Kaine (D-VA) told Vox. “It’s been a long time since we’ve done something meaningful on guns, a very long time, so if we’re able to do something solid, I think that could create conditions like ‘Hmm, Congress can act on guns.’”
</p>
<h3 id="F6RrY0">
What’s on the table
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6GaWug">
There are four main areas that the talks have focused on so far, according to a congressional aide. As Cornyn has repeatedly explained, whatever policy that emerges is <a href="https://www.nytimes.com/2022/06/06/us/politics/gun-control-cornyn-senate-republicans.html">likely to be “incremental” in nature</a>, though it would still be the most progress lawmakers have made on guns in years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bed5Ix">
Below are the four issues that lawmakers are currently discussing:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uXCyLl">
<strong>1.</strong> <strong>Red flag laws: </strong>A major component of any agreement is likely to be grants that incentivize states to either pass red flag laws or improve their implementation of them — an effort that builds on past negotiations between <a href="https://www.politico.com/story/2019/08/05/graham-red-flag-bill-gun-violence-1448198">Sens. Richard Blumenthal (D-CT) and Lindsey Graham (R-SC)</a>. Currently, <a href="https://www.vox.com/policy-and-politics/23158755/florida-red-flag-law">19 states and Washington, DC</a>, already have red flag laws, also known as extreme risk protection orders, which enable law enforcement to bar an individual from possessing firearms if they pose a risk to themselves or others.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8wCphc">
Whatever bill the Senate passes would be aimed at encouraging more states to pass these laws, and at helping states with existing ones impose them more effectively. As was evident in a recent mass shooting in Buffalo, the efficacy of a red flag law is <a href="https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2021/10/05/red-flag-laws-are-saving-lives-they-could-save-more">highly dependent on implementation</a>, as well as on law enforcement and the broader public being aware of how to properly utilize them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9nKcfx">
<strong>2. Enhancements to background checks: </strong>At this point, legislation that would impose universal background checks, much like <a href="https://www.politifact.com/article/2013/apr/30/summary-manchin-toomey-gun-proposal/">the bill introduced</a> by Sens. Joe Manchin and Pat Toomey in 2012, is not in contention due to Republican opposition. Instead, lawmakers are trying to see if more information can be required as part of background checks for 18- to 21-year-olds.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ad1Ma1">
For example, in the case of an 18-year-old attempting to buy a gun, senators are looking at whether additional information from their juvenile records, which are presently left out, could be included as part of a background check.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KeLPFp">
<strong>3. Mental health resources: </strong>There’s also talk about increasing funding for mental health programs, which could include measures that help states bolster their efforts. One bipartisan bill previously introduced <a href="https://www.blunt.senate.gov/news/press-releases/blunt-stabenow-announce-new-bill-to-expand-community-mental-health-and-addiction-services-nationwide">by Sens. Roy Blunt (R-MO) and Debbie Stabenow (D-MI)</a> could be a model — it would fund behavioral health clinics that help provide mental health and addiction services.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="y9yPeW">
<strong>4. School safety:</strong> And finally, there are discussions about policies to improve school safety and security, though lawmakers declined to share additional details about what this could include. Previously, <a href="https://www.congress.gov/bill/117th-congress/senate-bill/45?q=%7B%22search%22%3A%5B%22Education%22%5D%7D&amp;s=3&amp;r=6#:~:text=Introduced%20in%20Senate%20(01%2F26%2F2021)&amp;text=This%20bill%20allows%20local%20education,strengthen%20security%20on%20school%20premises.">Sen. Ted Cruz (R-TX)</a> has introduced legislation that would allow schools to use grant money for campus design and stronger security measures.
</p>
<h3 id="FEzmso">
Why it still matters even though it’s incremental
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oknI6S">
Anything the Senate passes is likely to be far less ambitious than what Democrats had hoped for and what experts say is needed to more significantly curb gun violence.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SMKCNV">
Earlier this week, <a href="https://www.vox.com/2022/6/2/23151914/house-democrats-gun-control-package">the House passed a sweeping package of proposals</a> including a ban on high-capacity magazines, a bill to raise the age limit for buying semiautomatic weapons from 18 to 21, and legislation that would require safer storage of guns in homes with minors. Policies like these could reduce gun violence by making it tougher to fire many rounds of ammunition at one time, and making it harder for younger people to obtain guns.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rPc4d0">
The House bills are widely expected to get blocked in the Senate, where any deal is poised to be quite limited.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rqPWiU">
Still, negotiators say it’s important to get something done in order to begin addressing public demands for more gun control, and show that it’s possible for Congress to make inroads on the issue. “We can help to build the muscle that we will use again by starting now,” Blumenthal told Vox.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NCx9p2">
<a href="https://www.cbsnews.com/news/chris-murphy-face-the-nation-transcript-2022-05-29/">Murphy has said</a>, too, that this could be an opportunity to demonstrate to Republican lawmakers that any backlash they may face for supporting gun control would actually be far less than what many fear. Because of how vocal a minority of Republican voters have been on the issue, many GOP lawmakers have been reluctant to take any action on gun control due to concerns about the electoral blowback and potential primary challenges they could face.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bksaSD">
As of now, there still isn’t a concrete agreement, but lawmakers were broadly hopeful going into the weekend on Thursday. Whatever emerges from these talks, they hope, will be a step forward in the wake of devastating recent tragedies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UUnSJF">
“Everybody wants to get this done this work period,” Murphy told reporters, noting that senators aimed to finalize a deal before leaving for their next recess.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PDhTwa">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5nkT2Y">
</p></li>
<li><strong>Why the return to the office isn’t working</strong> -
<figure>
<img alt="Aerial view of an large empty parking lot outside Capital One office building in Melville, New York, on March 2, 2022" src="https://cdn.vox-cdn.com/thumbor/kCu1c_DGrdBbpx8jzyJFeQmbE5k=/284x0:2083x1349/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70962658/1384841201.0.jpg"/>
<figcaption>
As companies call workers back to the office, many wonder what they’re doing there. | J. Conrad Williams, Jr./Newsday RM via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I don’t gain anything besides a commute.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oDuS8D">
Andres is back to the office three days a week, and like many knowledge workers, he’s not happy about it. He says that while he and the other executive assistants at his Boston law firm have been forced back, the attorneys haven’t been following the rules. That’s partly because the rules don’t quite make sense, and people in all types of jobs are only coming in because they have to, not because there’s a good reason to go in.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jJarPp">
“People have adapted to remote work, and truthfully, the firm has done a tremendous job at adapting in the pandemic,” said Andres, who would prefer going in two days, as long as others were actually there. “But I think it’s more the returning to work that they’re struggling on.” He, like a number of other office workers, spoke with Recode anonymously to avoid getting in trouble with his employer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wlBM40">
Andres enjoys working from home and thinks he does a good job of it — and it allows him to escape a long commute that has only gotten 45 minutes longer thanks to construction projects on his route.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bvxOjQ">
The majority of Americans don’t work from home, but among those who do, there’s a battle going on about where they’ll work in the future. And it’s not just people who enjoy remote work who are upset about the return to the office.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dtcAs1">
Those who want to be remote are upset because they enjoyed working from home and don’t understand why, after two years of doing good work there, they have to return to the office. People who couldn’t wait to go back are not finding the same situation they enjoyed before the pandemic, with empty offices and fewer amenities. Those who said they prefer hybrid — <a href="https://www.us.jll.com/content/dam/jll-com/documents/pdf/research/global/jll-workforce-preferences-barometer-mar-2022.pdf">60 percent of office workers</a> — are not always getting the interactions with colleagues they’d hoped for.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8Y1Q3A">
The reasons the return to the office isn’t working out are numerous. Bosses and employees have different understandings of what the office is for, and after more than two years of working remotely, everyone has developed their own varied expectations about how best to spend their time. As more and more knowledge workers return to the office, their experience at work — their ability to focus, their stress levels, their level of satisfaction at work — has <a href="https://futureforum.com/wp-content/uploads/2022/04/Future-Forum-Pulse-Report-April-2022.pdf">deteriorated</a>. That’s a liability for their employers, as the rates of job openings and quits are near record highs for professional and business services, according to <a href="https://www.bls.gov/jlt/data.htm">Bureau of Labor Statistics</a> data.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lRkI76">
There are, however, ways to make the return to the office better, but those will require some deep soul-searching about why employers want employees in the office and when they should let it go.
</p>
<h3 id="ldLurF">
The current situation
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0zHfSk">
For now, many employees are just noticing the hassle of the office, even if they’re going in way less than they did pre-pandemic. This is what’s known as the hybrid model, and even though people like the remote work aspect of it, for many it’s still unclear what the office part of it is for.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Lr0eav">
“If I go into the office and there are people but none of them are on my team, I don’t gain anything besides a commute,” Mathew, who works at a large payroll company in New Jersey, said. “Instead of sitting at my own desk, I’m sitting at a desk in Roseland.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lwNz13">
Mathew’s company is asking people to come in three days a week, but he says people are mostly showing up two.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yyl6CB">
Further complicating things is that, while the main reason hybrid workers cite for wanting to go into the office is to see colleagues, they also don’t want to be told when to go in, according to Nicholas Bloom, a Stanford professor who, along with other academics, has been conducting a large, ongoing study of remote workers called <a href="https://wfhresearch.com/">WFH Research</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2ijHfE">
Employees say that management has yet to really penalize people for failing to follow office guidance, likely out of fear of alienating a workforce in a climate where it’s so hard to hire and retain employees. Many others moved <a href="https://www.vox.com/recode/22714777/remote-work-from-home-city-suburbs-housing-traffic">farther from the office</a> during the pandemic, making the commute harder. The result is circular: People go into the office to see other people but then don’t actually see those people so they stop going into the office as much.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZymxuI">
With <a href="https://www.us.jll.com/en/trends-and-insights/research/workforce-preferences-barometer">70 percent</a> of office workers globally now back in the office at least one day a week, the excitement many people felt a few months ago is wearing off. For many, that novelty is turning into an existential question: Why are we ever here?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HWMLH5">
“It was sort of like the first day of school when you’re back from summer vacation and it’s nice to see people and catch up with them,” Brian Lomax, who works at the Department of Transportation in Washington, DC and who is expected to come in two days a week, said. “But now it’s, ‘Oh, hey, good to see you,’ and then you go on about your day,” an experience he says is the same as working from home and reaching out to people via Microsoft Teams.
</p>
<div class="c-float-right">
<aside id="pUrKcy">
<q>There’s actually been an uptick in virtual meetings, despite the return to office</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="akkZ5z">
Most of the people we spoke to use software like Teams, Slack, and Zoom to communicate even while they’re in the office, making the experience similar to home. If one person in a meeting is on a video call from home — say, because they’re immunocompromised, or they have child care duties, or it just happens to be the day they work from home that week — everyone is. There’s actually been an uptick in virtual meetings, despite the return to the office, according to Calendly. In April, 64 percent of meetings set up through the appointment scheduling software included videoconferencing or phone details, compared with 48 percent a year earlier.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ECfEyG">
One issue is that hybrid means different things from company to company and even team to team. Typically, it seems employers are asking workers to come in a set number of days per week, usually two or three. Some employers are specifying which days; some are doing it by teams; some are leaving it up to individual workers. Almost half of office visits are just once a week — and over a third of these visits are for less than six hours, according to data from workplace occupancy analytics company <a href="https://www.bloomberg.com/news/articles/2022-05-24/nearly-half-of-office-visits-this-year-are-for-once-a-week?sref=qYiz2hd0#xj4y7vzkg">Basking.io as reported by Bloomberg</a>. The middle of the week tends to be much busier than Mondays and Fridays, when there are empty cubicles as far as the eye can see.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VNydLv">
There’s also a disconnect between why employees think they’re being called in. Employees cite their company’s sunk real estate investments, their bosses’ need for control, and their middle managers’ raison d’etre. Employers, meanwhile, think going into the office is good for <a href="https://cps.northeastern.edu/wp-content/uploads/2022/01/NUReport_CFHETS_EmployersPostCovid_12-22-2021.pdf">creativity, innovation</a>, and culture building. Nearly 80 percent of employees think they’ve been just as or <a href="https://www.vox.com/recode/23129752/work-from-home-productivity">more productive</a> than they were before the pandemic, while less than half of leaders think so, according to <a href="https://www.microsoft.com/en-us/worklab/work-trend-index/great-expectations-making-hybrid-work-work">Microsoft’s Work Trends Index</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LEpIie">
Employers and employees generally tend to agree that a good reason to go into the office is to see colleagues face to face and onboard new employees. Data from Time Is Ltd. found that employees that started during the pandemic are collaborating with less than 70 percent of colleagues and clients as their tenured peers would have been at this point. Slack’s <a href="https://futureforum.com/pulse-survey/">Future Forum survey</a> found that while executives were more likely to say people should come into the office full time, they are less likely to do so themselves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="93PPdX">
The nature of individuals’ jobs also determines how much, if at all, they think they should be in the office. Melissa, a government policy analyst in DC, is supposed to go in twice a week but has only been going in once because she says her work involves collaborating with others but not usually at the same time. She might write a draft, send it to others to read, and then they’ll make comments and perhaps, at some point, they all get together to talk about it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BLAJOj">
“I see a lot of these ads for these teamwork apps — they always show these pictures of people sitting at a conference table and they have paper and all sorts of things on the wall and they’re really collaborating on product development or something,” Melissa said. “And I’m like, that’s not what we’re doing.” Still, she thinks that from managers’ perspectives, in-person is the gold standard, regardless of the actualities of the job.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dIZC5I">
“It feels like they just want people in the office,” she said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RRq128">
It also depends on the pace of work. A financing services employee at Wells Fargo in Iowa said he works more efficiently at the office but that since his job consists of working on deals that come in sporadically throughout the day, that efficiency means he ends up wasting a lot of time playing on his phone or pacing around the office in between.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zdqAII">
“What makes this so frustrating is that my wife will send me a photo of her and my 10-month-old son going out for a walk,” he said. “If I had a break at home, I’d go on a walk with them.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IFbqFP">
Employers are certainly feeling the frustration from their employees and have been walking back how much they’re asking employees to be in the office. Last summer, office workers reported that their employers would allow them to work from home 1.6 days a week; now that’s gone up to 2.3 days, according to WFH Research.
</p>
<div id="PLkzxr">
<div id="datawrapper-ivZiU">
</div></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tNzpoP">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZZAnKT">
Companies are rolling back return-to-office, or RTO, plans at <a href="https://www.bloomberg.com/news/articles/2022-05-11/wall-street-silicon-valley-return-to-office-plans-unravel-in-hot-job-market?sref=qYiz2hd0">law firms</a>, <a href="https://www.thezebra.com/resources/news/omicron-insurance-companies-remote-work/">insurance agencies</a>, and <a href="https://www.flexjobs.com/blog/post/companies-switching-remote-work-long-term/">everywhere in between</a>. Even finance companies like JPMorgan Chase, whose CEO has been especially vocal about asking people to return to their offices, <a href="https://www.nytimes.com/2022/04/04/business/wall-street-remote-work.html">have loosened up</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JQAUjv">
Tech companies have long been at the forefront when it comes to allowing hybrid or remote work, and now even more tech companies, including Airbnb, <a href="https://thinkremote.com/cisco-employees-work-from-home-policy/">Cisco</a>, and Twitter, are joining the club. Even <a href="https://www.vox.com/recode/22690190/apple-remote-work-from-home-employee-cher-scarlett-janneke-parrish">Apple</a>, which has been much stricter than its peers in coaxing employees back to the office, has <a href="https://www.wsj.com/articles/apple-pauses-plans-to-go-from-two-days-to-three-days-a-week-in-the-office-11652829935">paused</a> its plan to increase days in the office to three a week, after <a href="https://www.engadget.com/apple-criticized-by-employees-over-working-from-home-policy-in-open-letter-123027735.html?guccounter=1&amp;guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&amp;guce_referrer_sig=AQAAAKma4CwkPbkBTlBWIOid607ZNAyEjnU4g2ci8p8L3OA7gNmbmibb4ondaxUhEhWOKWSumQkk8z0fd3ncwvbLfMhZdwTIYEFa_weBIvf6mOrQgoDx-JHLbbYBLu-aRBaKEv2juR5OVb4pKYlyd3rjxkhDYfEXDmm6vNnMFEe5TciZ">employee pushback</a> and the <a href="https://twitter.com/ZoeSchiffer/status/1523017143939309568">resignation</a> of a prominent machine learning engineer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bIiJ5z">
It seems like, for now, office workers have the upper hand. Many don’t expect to be penalized by management for not working from the office when they’re supposed to, partly because they don’t think management believes in the rules themselves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QbnDgU">
“Our retention is better than expected and our employee engagement is better than expected, so I don’t think [our executives are] seeing any downside,” said Rob Carr, who works at an insurance company in Columbus, Ohio, where people are expected to be in three days a week but, as far as he’s seen, rarely go. “Honestly, if they were, I think they’d be cracking down, and they’re not.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wJArb6">
Carr himself goes into the office every day, but only because he and his wife downsized houses and moved a short bike ride from his office. Otherwise Carr, who is on the autism spectrum and says he doesn’t do well with in-person interactions, would be completely happy working from home as he is from his empty office.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Wv8WrK">
“Hats off to Apple for innovation,” Carr said, “but they are, certainly from a Silicon Valley perspective, an old company.”
</p>
<h3 id="KGRg92">
What to do about the broken return to the office
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A1Wy8e">
Solving the office conundrum is not easy, and in all likelihood it will be impossible to make everyone happy. But it’s important to remember that going to the office <a href="https://www.nytimes.com/2022/03/10/business/remote-work-office-life.html">never really worked for everyone</a>, it was just what everyone did. Now, two years after the pandemic sent office workers to their living rooms, their employers may have a chance to make more people happy than before.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k7A6Xr">
“The problem right now is you’ve set something that’s unrealistic and doesn’t work, and when employees try it out and it doesn’t work, they give up,” Bloom, the Stanford professor, said. “If employees refuse to come in, it means the system isn’t working.”
</p>
<div class="c-float-right">
<aside id="lPeIgW">
<q>“If employees refuse to come in, it means the system isn’t working”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="foFPnB">
To fix that, employers should explore not only why they want people in the office, but whether bringing people into the office is achieving those goals. If the main reason to bring people back is to collaborate with colleagues, for example, they need to set terms that ensure that happens. That could mean making people who should be working together come in on the same days — a problem around which a whole <a href="https://www.remote.tools/category/best-appointment-scheduling-software">cottage industry of remote scheduling software</a> has cropped up.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i5jCZ8">
That said, Bloom believes there’s no golden rule on how often it’s necessary to go in to get the benefits of the office. Importantly, when workers do come in, they shouldn’t be bogged down with anything they could be doing at home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SuIlUo">
“First, figure out how many days a week or a month constructively would it be good to have people face to face, and that depends on how much time you spend on activities that are best in person,” he said, referring to things like onboarding, training, and socializing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7g5vuL">
Employers need to be realistic about how much in-person work really needs to happen. Rather than making people come in a few times a week at random, where colleagues pass like ships in the night, they could all come in on the same day of the week or even once a month or quarter. And on those days, the perks of coming in have to be more than <a href="https://www.nytimes.com/2022/04/12/technology/rto-return-office-technology.html">tacos and T-shirts</a>, too. While fun, <a href="https://www.vox.com/the-goods/23054032/office-snacks-work-benefits">free food and swag</a> aren’t actually good reasons to go to the office.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L16ejb">
How much someone needs to come into the office might also vary by team or job type.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7Zsyzk">
“For me, coming in to do teaching and to go to research seminars, that might be twice a week,” Bloom said. “But for other people, like coders, it may just be a big coding meeting and a few trainings once a month. For people in marketing and advertising, mad men, that’s very much around meetings, discussions, problem-solving — that may be two or three days.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OrpmK0">
Another thing to consider, especially for those who truly like the office, is how they can get that experience with fewer of the downsides.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eCwvuy">
Currently, even employees who still like their offices a lot aren’t necessarily using them. Real estate services company JLL <a href="https://www.us.jll.com/en/trends-and-insights/research/workforce-preferences-barometer">found</a> that a third of office workers are using so-called “third places” like cafes and coworking spaces to work, even when they have offices they can go to.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6rMSoE">
Matt Burkhard, who leads a team of 30 at Flatiron Health, is one of those workers. He says he works better at an office than at home, where he has two young children. And while Burkhard enjoys going into his office and goes there once or twice per week, though he won’t be required to do so until later this summer, the trip to Manhattan isn’t always feasible, especially if he has to do child care for part of the day. So he’s been going to Daybase, a coworking space near his home, three or four times per week.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4SX4AZ">
“I’m just a lot more focused when everyone is in the same place working,” Burkhard said, noting that he hasn’t asked his company to pay for the $50 a month membership fee.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vHUPPh">
For many office workers, the current state of affairs just isn’t working out. So they’re doing what they can to make their experience of work better, whether that means renting coworking space or not showing up for arbitrary in-office days. They don’t necessarily hate the office. What they hate is not having a good reason to be there.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sri Lanka fined 40% of match fee for slow-over rate in second T20 against Australia</strong> - Australia lead the three-match series 2-0</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Forseti, Lake Tahoe, Shabelle, Inmywebelieve and Triple Wish excel</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amazon pulls out of high-stakes bidding battle for IPL telecast rights</strong> - Amazon’s decision comes just two days ahead of the bidding for IPL television and digital broadcast rights</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NADA to collect dope samples from all medal winners at athletics Nationals</strong> - Random samples will not be selected for testing</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lewis Hamilton made honorary citizen of Brazil, Pele congratulates him</strong> - “Today I was granted honorary citizenship to one of my favourite places in the world,” said Formula One driver Lewis Hamilton on being made a citizen of Brazil</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watch | Why does Assam flood every year?</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Telangana people wilting under high taxation and fares: Bandi</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘Dear Friend’ movie review: Tovino Thomas’ millenial drama wastes a promising build-up</strong> - Filmmaker Vineeth Kumar's second outing has an interesting premise, but what the film serves in the end — after all the painful work of building the suspense — is quite disappointing</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra Pradesh: YSRCP government has unleashed anarchy in State, alleges Naidu</strong> - ‘Its rule so far is marked by political murders, farmers’ suicide, unemployment, and atrocities on girls and women’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Storage in Cauvery basin dams above 50% of gross capacity</strong> - This is mainly due to the pre-monsoon showers coupled with cyclone-induced rains in May</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Putin: West unlikely to reject Russian energy for years</strong> - Russian president says oil and gas profits are increasing thanks to rising energy prices.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Border rapist trial starts in France for 56 attacks</strong> - Dino Scala is accused of a 30-year series of rapes and sexual assaults.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>French elections: Left unites to threaten Macron in parliamentary vote</strong> - A five-party alliance led by Jean-Luc Mélenchon aims to deny the president control of parliament.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>French elections: Who is Mélenchon and what does his NUPES alliance want?</strong> - He leads a left-wing alliance aiming to stop President Macron controlling the next government.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia’s new version of McDonald’s unveils logo</strong> - It comes as the fast food chain is due to reopen 15 of the rebranded restaurants this weekend.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPS Black brings impressive contrast and vivid colors to Dell’s UltraSharp U2723QE</strong> - Great port selection, clean looks, and a more vibrant picture than normal IPS. - <a href="https://arstechnica.com/?p=1856071">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New ultra-stealthy Linux backdoor isn’t your everyday malware discovery</strong> - Symbiote gives remote access to any account. Normal methods don’t detect it. - <a href="https://arstechnica.com/?p=1860089">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>All the games, trailers, and announcements from the 2022 Summer Game Fest</strong> - From <em>Aliens</em> to <em>Cuphead</em> and everything in between. - <a href="https://arstechnica.com/?p=1860076">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Report reveals 15-inch MacBook Air release window, M2 Max core count</strong> - Apple is also planning a new 12-inch MacBook, sources say. - <a href="https://arstechnica.com/?p=1860016">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>US can’t afford fall boosters for all—even after cuts to test and PPE spending</strong> - “These were incredibly painful decisions.” - <a href="https://arstechnica.com/?p=1860055">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>An old farmer got up in the middle of the night to use the toilet.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
As he was heading back to bed, he looked out the window and saw the lights on in his shed. A closer inspection revealed men loading his tools and farm machinery into their truck.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He rushes to the phone and calls 000 (911)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I need the police! There are some guys clearing out my shed!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“OK sir, we have dispatched officers, they should be there in about an hour.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“An hour?! But they’ll be long gone by then!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I’m sorry sir but there are no officers in your area.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The farmer hangs up angrily, waits 10 minutes and then calls 000 again.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Hi, it’s me again. Don’t worry about sending those cops, I’ve just shot the robbers.” and he hangs up.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Less then 10 minutes later, three cop cars and a helicopter arrive and the robbers are arrested. The sergeant goes up to the house and bangs on the door. The farmer opens it in his dressing gown and holding a cup of tea.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“What’s going on here!? You said you shot the robbers!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“You said there were no officers in my area.”
</p>
</div>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Plague001"> /u/Plague001 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v8vyjg/an_old_farmer_got_up_in_the_middle_of_the_night/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v8vyjg/an_old_farmer_got_up_in_the_middle_of_the_night/">[comments]</a></span></p></li>
<li><strong>Four doctors are talking. “The British doctor says, medicine is so advanced in Britain that we cut off a man’s liver, put it in another man, and in 6 weeks, he was looking for a job.”</strong> - <!-- SC_OFF -->
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The German doctor replies: “That’s nothing. In Germany, we took part of a brain, put it in another man, and in 4 weeks he was looking for a job.”
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The Russian doctor replies: “Well, we took half a heart from a man, put it in another’s chest, and in 2 weeks he was looking for a job.”
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The American doctor laughs: “You are all behind us. A few years ago, we took a man with no brain, no heart, and no liver, and made him President. Now, the whole country is looking for a job!”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v8uqks/four_doctors_are_talking_the_british_doctor_says/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v8uqks/four_doctors_are_talking_the_british_doctor_says/">[comments]</a></span></p></li>
<li><strong>As a new adult I realized how bad inflation got when I paid for my first prostitute.</strong> - <!-- SC_OFF -->
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My grandpa used to say it something about how it was only “a penny for your thots”.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Mai_man"> /u/Mai_man </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v8w6f9/as_a_new_adult_i_realized_how_bad_inflation_got/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v8w6f9/as_a_new_adult_i_realized_how_bad_inflation_got/">[comments]</a></span></p></li>
<li><strong>An Irishman is walking on a beach when he stubs his toe on an old metal box</strong> - <!-- SC_OFF -->
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He opens the lid And a Genie pops out and praises him for letting him out after 500 years…
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He offers him a wish… and the Irishman says… every evening after dinner when I pee, I want to pee the finest Irish Whiskey…
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Done says the genie and vanishes in a flash…
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That evening after dinner he puts two glasses on the table and proceeds to fill them with the whiskey….
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He and his wife absolutely swear it’s the best whiskey they’ve ever drunk.
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This continues for the entire week
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On that Friday the wife prepares dinner and after clearing the dishes, sees only one glass on the table…
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She says Hon’ Where’s my glass?
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Tonight - You drink from the bottle!
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Dashover"> /u/Dashover </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v8f22c/an_irishman_is_walking_on_a_beach_when_he_stubs/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v8f22c/an_irishman_is_walking_on_a_beach_when_he_stubs/">[comments]</a></span></p></li>
<li><strong>Prostitute Joke.</strong> - <!-- SC_OFF -->
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Man : How much for a blowjob?
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Prostitute : Ummm $20
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Man : Ohhh Damn, it was $80 for my friend. I guess I am your favourite.
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Prostitute : Cut it out, I charge $10 per inch.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Omkarop_06"> /u/Omkarop_06 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/v8ha6p/prostitute_joke/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/v8ha6p/prostitute_joke/">[comments]</a></span></p></li>
</ul>
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