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+ + + ++Coronavirus disease 2019 (COVID-19) vaccine shortages have led some experts and countries to consider untested dosing regimens. We studied antibody responses to a single dose of the Pfizer-BioNTech or Moderna vaccines in healthcare workers (HCW) with laboratory-confirmed COVID-19 infection and compared to them to antibody responses of HCW who were IgG negative to SARS-CoV-2 spike protein. HCW with prior COVID-19 showed clear secondary antibody responses to vaccination with IgG spike binding titers rapidly increasing by 7 days and peaking by days 10 and 14 post-vaccination. At all time points tested, HCW with prior COVID-19 infection showed statistically significant higher antibody titers of binding and functional antibody compared to HCW without prior COVID-19 infection (p<.0001for each of the time points tested). In times of vaccine shortage, and until correlates of protection are identified, our findings preliminarily suggest the following strategy as more evidence-based: a) a single dose of vaccine for patients already having had laboratory-confirmed COVID-19; and b) patients who have had laboratory-confirmed COVID-19 can be placed lower on the vaccination priority list. +
++Background: This systematic review and meta-analysis was aimed to evaluate the therapeutic benefits and safety of tocilizumab (TCZ) in treating severe coronavirus disease 2019 (COVID-19) and associated health complications. Methods: The electronic search was performed using PubMed, Scopus, CENTRAL (Cochrane Central Register of Controlled Trials (RCTs), and Google scholar databases to identify the retrospective observational reports. The studies published from 01 January 2020 to 30th September 2020 involving comparison of TCZ group with SOC/control treatment group were included. The studies included in this work involve RT-PCR confirmed cases of COVID-19 (Population), having tocilizumab and corresponding SOC/control as interventions (Intervention), comparison between tocilizumab versus SOC/control (Comparison) for the parameter of interest. Mortality, incidences of ICU admission, need of mechanical ventilation (MV), length of stay in the hospital (LOS), and length of stay in the ICU (LOS-ICU), and the incidences of super-infection, bacteraemia, fugleman, pneumonia, and pulmonary thrombosis were evaluated as the primary outcomes. The comparison will be between TCZ versus standard of care (SOC)/placebo. Results: Based on the inclusion criteria there were 24 retrospective studies involving 5686 subjects were included. The outcomes of the meta-analysis have revealed that the TCZ has reduced the mortality (Mantel-Haenszel (M-H), random effects risk difference (RE-RD) of -0.11 (-0.18 to -0.04), at 95% CI, p = 0.001, I2 = 88%) and increased the incidences of super-infections (M-H, RE-Risk ratio (RR) of 1.49 (1.13 to 1.96) at 95% CI, p=0.004, I2 = 47%). However, there is no significant difference in ICU admissions rate (M-H, RE-RD of -0.06 (-0.23 to 0.12) at 95% CI, p=0.54, I2 = 93%), need of MV (M-H, RE-RD of 0.00 (-0.06 to 0.07) at 95% CI, p=0.96, I2 = 74%), LOS (Inverse variance (IV): -2.86 (-0.91 to 3.38) at 95% CI, p=0.37, I2 = 100%), LOS-ICU (IV: -3.93 (-12.35 to 4.48) at 95% CI, p=0.36, I2 = 100%), and incidences of pulmonary thrombosis (M-H, fixed effect odds ratio (FE-OR) of 1.01 (0.45 to 2.26) at 95% CI, p=0.99, I2 = 0%) compared to SOC/control. Conclusion: This meta-analysis was performed using retrospective clinical reports on the use of tocilizumab in COVID-19 and based on the outcomes of the meta-analysis we can conclude that administration of TCZ would reduce the risk of mortality, and however there is no much difference observed between the TCZ and SOC/control groups in other parameters such as ICU admission rate, need of mechanical ventilation and length of hospital stay (ICU and Non-ICU). On the other hand, TCZ treated subjects possess higher chances of super-infections and pneumonia compared with SOC/control group. However, there is a need for multi-centric randomized trials to determine the potential therapeutic role of TCZ in mitigating COVID-19 and associated health complications. +
++The role of human behavior to thwart transmission of infectious diseases like COVID-19 is evident. Yet, many areas of psychological and behavioral science are limited in the ability to mobilize to address exponential spread or provide easily translatable findings for policymakers. Here we describe how integrating methods from operant and cognitive approaches to behavioral economics can provide robust policy relevant data. Adapting well validated methods from behavioral economic discounting and demand frameworks, we evaluate in four crowdsourced samples (total N = 1,366) behavioral mechanisms underlying engagement in preventive health behaviors. We find that people are more likely to social distance when specified activities are framed as high risk, that describing delay until testing (rather than delay until results) increases testing likelihood, and that framing vaccine safety in a positive valence improves vaccine acceptance. These findings collectively emphasize the flexibility of methods from diverse areas of behavioral science for informing public health crisis management. +
++Background: Preliminary evidence has shown inequities in COVID-19 related cases and deaths in the US. Objective: We explored the emergence of spatial inequities in COVID-19 testing, positivity, confirmed cases, and mortality in New York City, Philadelphia, and Chicago during the first six months of the pandemic. Design: Ecological, observational study at the zip code tabulation area (ZCTA) level from March to September 2020. Setting: Chicago, New York City and Philadelphia. Participants: All populated ZCTAs in the three cities. Measures: Outcomes were ZCTA-level COVID-19 testing, positivity, confirmed cases, and mortality cumulatively through the end of September. Predictors were the CDC social vulnerability index and its four domains, obtained from the 2014-2018 American Community Survey. We examined spatial clusters of COVID-19 outcomes using local Moran9s I and estimated associations using spatial conditional autoregressive negative binomial models. Results: We found spatial clusters of high and low positivity, confirmed cases and mortality, co-located with clusters of low and high social vulnerability. We also found evidence for the existence of spatial inequities in testing, positivity, confirmed cases and mortality for the three cities. Specifically, neighborhoods with higher social vulnerability had lower testing rates, higher positivity ratios, confirmed case rates and mortality rates. Limitations: ZCTAs are imperfect and heterogeneous geographical units of analysis. We rely on surveillance data, which may be incomplete. Conclusion: We found spatial inequities in COVID-19 testing, positivity, confirmed cases, and mortality in three large cities of the US. +
++Background: We aimed at identifying vaccination strategies that minimize loss of life in the Covid-19 pandemic. Covid-19 mainly kills the elderly, but the pandemic is driven by social contacts that are more frequent in the young. Vaccines elicit stronger immune responses per dose in younger persons. As vaccine production is a bottleneck, many countries have adopted a strategy of first vaccinating the elderly and vulnerable, while postponing vaccination of the young. Methods: Based on published age-stratified immunogenicity data of the Moderna mRNA-1273 vaccine, we compared the established 9one dose fits all9 approach with tailored strategies: The known differential immunogenicity of vaccine doses in different age groups is exploited to vaccinate the elderly at full dose, while the young receive a reduced dose, amplifying the number of individuals receiving the vaccine early. A modeling approach at European Union scale with population structure, Covid-19 case and death rates similar to Europe in late January 2021 is used. Results: When the elderly were vaccinated preferentially, the pandemic initially continued essentially unchecked, as it was dominantly driven by social contacts in other age groups. Tailored strategies, including regular dosing in the elderly but reduced dose vaccination in the young, multiplied early vaccination counts, and even with some loss in protection degree for the individual person, the protective effect towards stopping the pandemic and protecting lives was enhanced, even for the elderly. Conclusion: Protecting the vulnerable, minimizing overall deaths and stopping the pandemic is best achieved by an adaptive vaccination strategy using an age-tailored vaccine dose. +
++Objectives: The early stages of the COVID-19 pandemic illustrated that SARS-CoV-2, the virus that causes the disease, has the potential to spread exponentially. Therefore, as long as a substantial proportion of the population remains susceptible to infection, the potential for new epidemic waves persists even in settings with low numbers of active COVID-19 infections, unless sufficient countermeasures are in place. We aim to quantify vulnerability to resurgences in COVID-19 transmission under variations in the levels of testing, tracing, and mask usage. Setting: The Australian state of New South Wales, a setting with prolonged low transmission, high mobility, non-universal mask usage, and a well-functioning test-and-trace system. Participants: None (simulation study) Results: We find that the relative impact of masks is greatest when testing and tracing rates are lower (and vice versa). Scenarios with very high testing rates (90% of people with symptoms, plus 90% of people with a known history of contact with a confirmed case) were estimated to lead to a robustly controlled epidemic, with a median of ~180 infections in total over October 1 - December 31 under high mask uptake scenarios, or 260-1,200 without masks, depending on the efficacy of community contact tracing. However, across comparable levels of mask uptake and contact tracing, the number of infections over this period were projected to be 2-3 times higher if the testing rate was 80% instead of 90%, 8-12 times higher if the testing rate was 65%, or 30-50 times higher with a 50% testing rate. In reality, NSW diagnosed 254 locally-acquired cases over this period, an outcome that had a low probability in the model (4-7%) under the best-case scenarios of extremely high testing (90%), near-perfect community contact tracing (75-100%), and high mask usage (50-75%), but a far higher probability if any of these were at lower levels. Conclusions: Our work suggests that testing, tracing and masks can all be effective means of controlling transmission. A multifaceted strategy that combines all three, alongside continued hygiene and distancing protocols, is likely to be the most robust means of controlling transmission of SARS-CoV-2. +
++Objectives Use of Personal Protective Equipment (PPE) has been central to controlling spread of SARS-CoV2. Here we quantify the environmental impact of PPE distributed for use by the health and social care system in England, and model strategies for mitigating the environmental impact. Methods Life cycle assessment was used to determine environmental impacts of PPE distributed to health and social care in England during the first six months of the COVID-19 pandemic. The base scenario assumed all products were single-use and disposed of via clinical waste. Scenario modelling was used to determine the effect of environmental mitigation strategies; 1) eliminating international travel during supply, 2) eliminating glove use 3) reusing gowns and face shields, 4) maximal recycling. Results The carbon footprint of PPE distributed during the study period totalled 106,478 tonnes CO2e, with greatest contributions from gloves, aprons, face shields, and Type IIR surgical masks. The estimated damage to human health was 239 DALYs (disability adjusted life years), impact on ecosystems was 0.47 species.year (loss of local species per year), and impact on resource depletion was costed at US $ 12.7 (GBP 9.3) million. Scenario modelling indicated UK manufacture would have reduced the carbon footprint by 12%, eliminating gloves by 45%, reusing gowns and gloves by 10%, and maximal recycling by 35%. A combination of strategies may have reduced carbon footprint by 75% compared with the base scenario, and saved an estimated 183 DALYS, 0.34 species.year, and US $ 7.4 (GBP 5.4) million due to resource depletion. Conclusions The environmental impact of PPE is large and could be reduced through domestic manufacture, rationalising glove use, using reusables where possible, and optimising waste management. +
+Phase III Study of AZD7442 for Treatment of COVID-19 in Outpatient Adults - Condition: COVID-19
Interventions: Drug: AZD7442; Drug: Placebo
Sponsor: AstraZeneca
Not yet recruiting
Fluvoxamine Administration in Moderate SARS-CoV-2 (COVID-19) Infected Patients - Condition: Covid19
Interventions: Drug: Placebo; Drug: Fluvoxamine
Sponsor: SigmaDrugs Research Ltd.
Recruiting
TOCILIZUMAB - An Option for Patients With COVID-19 Associated Cytokine Release Syndrome; A Single Center Experience - Condition: Covid19
Intervention: Drug: Tocilizumab
Sponsor: FMH College of Medicine and Dentistry
Completed
APT™ T3X on the COVID-19 Contamination Rate - Condition: COVID-19
Interventions: Drug: Tetracycline hydrochloride 3%; Drug: Placebo
Sponsors: University of Nove de Julho; Santa Casa de Misericórdia de Porto Alegre
Not yet recruiting
COVID-19 Immunologic Antiviral Therapy With Omalizumab - Condition: Covid19
Interventions: Biological: Omalizumab; Other: Placebo
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Not yet recruiting
An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization - Condition: Covid19
Interventions: Drug: Ivermectin Tablets; Drug: Doxycycline Tablets; Drug: Placebo
Sponsor: Max Health, Subsero Health
Recruiting
Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19 - Condition: COVID-19
Interventions: Drug: Doxycycline Tablets; Drug: Rivaroxaban 15Mg Tab; Combination Product: Hydroxychloroquine and Azithromycin
Sponsor: Yaounde Central Hospital
Recruiting
Phase IIb Clinical Trial of Recombinant Novel Coronavirus Pneumonia (COVID-19) Vaccine (Sf9 Cells) - Condition: COVID-19
Interventions: Biological: Recombinant COVID-19 vaccine (Sf9 cells); Biological: Placebo
Sponsors: Jiangsu Province Centers for Disease Control and Prevention; West China Hospital
Not yet recruiting
Famotidine vs Placebo for the Treatment of Non-Hospitalized Adults With COVID-19 - Condition: Covid-19
Interventions: Drug: Famotidine; Drug: Placebo
Sponsors: Northwell Health; Cold Spring Harbor Laboratory
Recruiting
COVID-19 and Pregnancy: Placental and Immunological Impacts - Condition: Covid19
Intervention: Other: Specimens specific for the study
Sponsor: Hopital Foch
Recruiting
Study to Assess Efficacy and Safety of Inhaled Interferon-β Therapy for COVID-19 - Conditions: Severe Acute Respiratory Syndrome Coronavirus 2; COVID-19
Interventions: Drug: SNG001; Drug: Placebo
Sponsor: Synairgen Research Ltd.
Recruiting
Convalescent Plasma in the Treatment of Covid-19 - Condition: Covid19
Interventions: Biological: Convalescent plasma from COVID-19 donors; Biological: Placebo
Sponsors: Helsinki University Central Hospital; Finnish Red Cross
Recruiting
Early Use of Hyperimmune Plasma in COVID-19 - Condition: Covid19
Intervention: Other: hyperimmune plasma
Sponsors: Catherine Klersy; Policlinico San Matteo Pavia Fondazione IRCCS
Recruiting
Efficacy of Nano-Ivermectin Impregnated Masks in Prevention of Covid-19 Among Healthy Contacts and Medical Staff - Condition: Covid-19
Intervention: Other: ivermectin impregnated mask
Sponsor: South Valley University
Recruiting
Restoration of Endothelial Integrity in Patients With COVID-19 (RELIC) - Condition: COVID-19
Intervention: Biological: Thawed plasma
Sponsor: University of Alabama at Birmingham
Not yet recruiting
The SARS-Coronavirus Infection Cycle: A Survey of Viral Membrane Proteins, Their Functional Interactions and Pathogenesis - Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus disease 2019 (COVID-19), a global health crisis. Other epidemic Betacoronaviruses include the 2003 SARS-CoV-1 and the 2009 Middle East Respiratory Syndrome Coronavirus (MERS-CoV), the genomes of which, particularly that of SARS-CoV-1, are similar to that of the 2019 SARS-CoV-2. In this extensive review, we document the most...
Computational Determination of Potential Multiprotein Targeting Natural Compounds for Rational Drug Design Against SARS-COV-2 - SARS-CoV-2 caused the current COVID-19 pandemic and there is an urgent need to explore effective therapeutics that can inhibit enzymes that are imperative in virus reproduction. To this end, we computationally investigated the MPD3 phytochemical database along with the pool of reported natural antiviral compounds with potential to be used as anti-SARS-CoV-2. The docking results demonstrated glycyrrhizin followed by azadirachtanin, mycophenolic acid, kushenol-w and 6-azauridine, as potential...
Immunogenic BNT162b vaccines protect rhesus macaques from SARS-CoV-2 - A safe and effective vaccine against COVID-19 is urgently needed in quantities sufficient to immunise large populations. We report the preclinical development of two BNT162b vaccine candidates, which contain lipid-nanoparticle (LNP) formulated nucleoside-modified mRNA encoding SARS-CoV-2 spike glycoprotein-derived immunogens. BNT162b1 encodes a soluble, secreted, trimerised receptor-binding domain (RBD-foldon). BNT162b2 encodes the full-length transmembrane spike glycoprotein, locked in its...
A drug repurposing screen identifies hepatitis C antivirals as inhibitors of the SARS-CoV2 main protease - Effective SARS-CoV-2 antiviral drugs are desperately needed. The SARS-CoV-2 main protease (Mpro) appears as an attractive target for drug development. We show that the existing pharmacopeia contains many drugs with potential for therapeutic repurposing as selective and potent inhibitors of SARS-CoV-2 Mpro. We screened a collection of ~6,070 drugs with a previous history of use in humans for compounds that inhibit the activity of Mpro in vitro and found ~50 compounds with activity against Mpro....
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models - The outbreak of coronavirus disease 2019 (COVID-19) has resulted in a global pandemic due to the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the time of this manuscript's publication, remdesivir is the only COVID-19 treatment approved by the United States Food and Drug Administration. However, its effectiveness is still under question due to the results of the large Solidarity Trial conducted by the World Health Organization. Herein, we report that the parent...
Ruxolitinib as adjunctive therapy for secondary hemophagocytic lymphohistiocytosis: a case series - CONCLUSIONS: This series demonstrates the effective use of JAK inhibition with ruxolitinib to control pathological immune activation in critically ill patients with secondary HLH and otherwise limited therapeutic options. JAK inhibition is also an area of urgent investigation for the treatment of cytokine storm associated with COVID-19.
Structural basis of SARS-CoV-2 polymerase inhibition by Favipiravir - The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogues, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs by targeting the viral polymerases. However, the underlying mechanisms for the antiviral efficacies of these drugs are far from well understood. Here we reveal that Favipiravir, as a pyrazine derivative, could be incorporated into the viral RNA products...
Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19 - Authors' reply - No abstract
Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19 - No abstract
Efficacy matters: broadening complement inhibition in COVID-19 - No abstract
Efficacy matters: broadening complement inhibition in COVID-19 - Authors' reply - No abstract
Antiviral activity of sulfated polysaccharides from marine algae and its application in combating COVID-19: Mini review - Marine-derived sulfated polysaccharides possess various antiviral activities against a broad range of enveloped and non-enveloped viruses. It has become the potential source of antiviral drugs for pharmaceutical development. In this review, we will discuss the different types of sulfated polysaccharides and their structural classification. Some of the major sulfated polysaccharides with potent antiviral activity, including carrageenan, agar, ulvan, fucoidan, and alginates, are considered in this...
Hypoxia-inducible factor (HIF): The link between obesity and COVID-19 - The COVID-19 death toll has involved to date more than 1 million confirmed deaths. The death rate is even higher in the obese COVID-19 patients, as a result of hypoxia, due to the interplay between adipose tissue hypoxia and obstructive sleep apnea. The discrepancy of manifestations seen in COVID-19 seems to be mediated by a differential immune response rather than a differential viral load. One of the key players of the immune response is HIF. HIF-1β is a stable constitutively expressed protein...
Manipulated bio antimicrobial peptides from probiotic bacteria as proposed drugs for COVID-19 disease - Coronavirus disease 19 (COVID-19) is the latest pandemic resulted from the coronavirus family. Due to the high prevalence of this disease, its high mortality rate, and the lack of effective treatment, the need for affordable and accessible drugs is one of the main challenges in this regard. It has been proved that RdRp, 3CL, Spike, and Nucleocapsid are the most important viral proteins playing vital roles in the processes of proliferation and infection. Therefore, we started studying a wide...
Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach - CONCLUSION: Our study highlights the potential of existing mushroom-derived natural compounds for further investigation and possibly can be used to fight against SARS-CoV-2 infection.
SARS-CoV-2 antibodies - - link
SARS-CoV-2 antibodies - - link
A PHARMACEUTICAL COMPOSITION OF NITAZOXANIDE AND MEFLOQUINE AND METHOD THEREOF - A pharmaceutical composition for treating Covid-19 virus comprising a therapeutically effective amount of a nitazoxanide or its pharmaceutically acceptable salts thereof and an mefloquine or its pharmaceutically acceptable salts thereof is disclosed. The pharmaceutical composition comprises the nitazoxanide in the ratio of 0.05% to 66% w/v and the mefloquine in the ratio of 0.05% to 90% w/v. The composition is found to be effective for the treatment of COVID -19 (SARS-CoV2). The pharmaceutical composition of nitazoxanide and mefloquine has been found to be effective and is unexpectedly well tolerated with a low rate of side-effects, and equally high cure-rates than in comparable treatments. - link
TREATMENT OF COVID-19 WITH REBAMIPIDE - - link
METHOD AND APPARATUS FOR ACQUIRING POWER CONSUMPTION IMPACT BASED ON IMPACT OF COVID-19 EPIDEMIC - - link
A PHARMACEUTICAL COMPOSITION OF ARTESUNATE AND MEFLOQUINE AND METHOD THEREOF - A pharmaceutical composition for treating Covid-19 virus comprising a therapeutically effective amount of an artesunate or its pharmaceutically acceptable salts thereof and a mefloquine or its pharmaceutically acceptable salts thereof is disclosed. The pharmaceutical composition comprises the artesunate in the ratio of 0.25% to 66% w/v and mefloquine in the ratio of 0.25% to 90% w/v. The composition is found to be effective for the treatment of COVID -19 (SARS-CoV2). The pharmaceutical composition of Artesunate and Mefloquine has been found to be effective and is unexpectedly well tolerated with a low rate of side-effects, and equally high cure-rates than in comparable treatments. The present invention also discloses a method to preparing the pharmaceutical composition comprising of Artesunate and Mefloquine. - link
+
Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.
一种医用可佩戴式防护口鼻的微型气幕系统 - 本发明公开了一种医用可佩戴式防护口鼻的微型气幕系统,包括框柱,框柱一侧开凿有气幕送风口和呼吸用送风口,气幕送风口和呼吸用送风口内分别连接有软管一和软管二,框柱内开凿有水平条缝和垂直条缝,水平条缝与垂直条缝均与气幕送风口相连通,框柱靠近水平条缝的一侧贯穿开凿有出风口,出风口内设有滤网,出风口贯穿框柱的一端连接有高效过滤器,滤网与高效过滤器之间连接有吸气泵,框柱靠近出风口的一侧连接有电池和开关。本发明通过提出一种在口腔处应用洁净空气幕阻挡气溶胶传播的可佩戴装置,可以在口腔类相关诊疗过程,保护医生和周围人的健康,避免引起可能引发的呼吸道疾病交叉感染。 - link
COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS - - link
+
Vorrichtung (10) umfassend einen Schutzschirm (12) und einen Filter (14) zum Herausfiltern von Viren (16) aus einem Schall erzeugenden Luftstrom (18), der von einem Musiker (20) beim Musizieren mit einem Musikinstrument oder beim Singen erzeugt wird, wobei der Schutzschirm (12) zur Verringerung des Risikos einer Infektion mit den Viren (16) dafür vorgesehen ist, wenigstens einen Teil der mit dem Luftstrom transportierten Viren (16) aufzufangen, der Schutzschirm (12) eine erste Seite (22) und eine zweite Seite (24) aufweist, die voneinander abgewandt sind, und der Schutzschirm (12) wenigstens einen sich von der ersten (22) bis zu der zweiten Seite (24) erstreckenden Durchlass (26) aufweist, wobei dieser Durchlass (26) zum Durchströmen mit wenigstens einem Teil des beim Musizieren erzeugten Luftstroms (18) vorgesehen ist und der Filter (14) zum Herausfiltern von Viren (16) aus dem Luftstrom (18) in dem Durchlass (26) des Schutzschirms (12) angeordnet ist.
The Three Biggest Lessons of the Coronavirus Economy - Nearly a year into the pandemic, solving the economic crisis means defeating the virus. - link
The Biden Administration’s Landmark Day in the Fight for the Climate - The newly announced actions may well mark the beginning of the end of the fossil-fuel era. - link
The Coronavirus Vaccine Presents a Dilemma for Pregnant Women - Vaccine trials have excluded the pregnant population, even though women of reproductive age make up a majority of frontline workers. - link
A Pennsylvania Mother’s Path to Insurrection - How claims from Rudy Giuliani and Alex Jones spurred a parent of eight to become one of the Capitol riot’s biggest mysteries and a fugitive from the F.B.I. - link
How Black Lives Matter Came to the Academy - The #BlackInTheIvory hashtag helped to surface decades of bias at universities. - link
+Biden is continuing to prioritize immigration during his first weeks in office. +
++President Joe Biden will announce three executive orders on Tuesday that are aimed at reuniting families separated by the Trump administration, improving access to the asylum system, and removing barriers to legal immigration. +
++It’s the second batch of executive actions on immigration that the president will have issued since taking office, signaling his continued commitment to the issue as a key priority. +
++The first seven executive actions that Biden issued concerned a number of former President Donald Trump’s most controversial immigration policies: the travel ban, construction of the southern border wall, and his attempt to end protections for young undocumented immigrants through the Deferred Action for Childhood Arrivals program. In some ways, these early actions represented the low-hanging fruit; Biden could walk back Trump’s policies quickly and with immediate, visible effect. +
++According to a memo shared with reporters, Tuesday’s actions are instead directed at undoing Trump’s complex web of regulations and policy changes and laying out some of Biden’s priorities to reform the immigration system administratively. While immigrant advocates were hoping that he might end pandemic-related restrictions on visas and at the border or a program that has trapped asylum seekers in Mexico, it’s now clear that those policy changes won’t happen immediately. +
++Here’s what Biden is expected to announce: +
++Biden will announce the creation of a task force to reunite separated immigrant families — the first step in making amends for one of the Trump administration’s cruelest immigration policies. +
++A federal judge ordered the Trump administration to stop the separations in 2018 after more than 5,000 families were separated. Attorneys still can’t find the parents of more than 600 children who were identified as part of a court settlement; many of the parents were deported back to their home countries, while others are believed to be in the US. But there may be many more affected children who have yet to be identified. +
++The task force, which will be chaired by the Secretary of Homeland Security (Alejandro Mayorkas, Biden’s nominee, is expected to be confirmed on Tuesday) would aim to identify any remaining separated children, reunite them with their parents and make recommendations as to how to ensure that the federal government does not repeat the policies and practices that led to the separations. +
++A senior administration official said that the task force will examine each case on an individual basis, taking into account the preferences of the parents and the well-being of the children. They might consider offering visas or immigration parole, a kind of temporary permission to enter the US, to affected families, the official said. +
++Lee Gelernt, an American Civil Liberties Union attorney representing separated families, has been calling on the administration to also facilitate congressional hearings investigating the policy, offering the families legal status in the US and setting up a victims fund, among other provisions. +
++“All the families must be immediately reunited in the United States, and then given permanent legal status and restitution for the abuse they suffered under the Trump administration,” he told Vox. +
++There also remains a question at to what should happen to families that have been separated again after being reunited, usually in cases where the parents are deported while the children have pending applications for protection in the US. +
++Biden will issue an executive order implementing a broad, three-part plan to improve access to the asylum system and address the root causes of migration. +
++According to the memo, the administration will address the “instability, violence and economic insecurity” that is driving Central American migrants out of the their home countries. It will work with foreign governments, international organizations and nonprofits to ensure that people can seek asylum and economic opportunities in Central America as an alternative to traveling to the US. And it will develop policies to ensure that migrants arriving on the southern border can seek protections to which they are legally entitled, as well as eliminate or review ones promulgated by the Trump administration that all but shut the door on asylum seekers. +
++Among the policies that the Biden administration will be required to review under the executive order is the Migrant Protection Protocols, also known as the “Remain in Mexico” policy, under which Trump sent tens of thousands of migrants back to Mexico to wait for their court hearings in the US. +
++More than 67,000 migrants are currently enrolled, or were previously subject to the program, a number of whom continue to wait in encampments along the US-Mexico border to be called in for their court dates in the US. Before the pandemic, asylum seekers would often have to wait months for a hearing. But in March, the Trump administration suspended all their hearings indefinitely on account of the Covid-19 pandemic. +
++Biden has started winding down the policy, ceasing to newly enroll migrants in the program as of January 21. But he has so far stopped short of ending it entirely. +
++A senior administration official said that people who are currently enrolled in the program will be offered a new pathway to pursue their petitions for protection once Biden develops broader policies to process asylum seekers. The administration does not have a timeline for implementing those policies yet, but the official said that people subject to MPP will be prioritized, given how long they have been waiting and the conditions in which they have been waiting. +
++The administration will have to consider who among the migrants subject to MPP are the most vulnerable and how they can process them while maintaining safeguards for public health amid the pandemic. +
++Biden will issue an executive order reviewing Trump-era regulations, policies, and guidance that have made it harder for people to legally immigrate to the US, including the controversial “public charge” rule. +
++The complex, 217-page rule imposes a wealth test on immigrants applying to enter the US, extend their visa, or convert their temporary immigration status into a green card. The rule represents one of Trump’s harshest blows to legal immigration yet and has had the effect of deterring immigrants from seeking out much-needed public services amid the pandemic. +
++Though the administration isn’t rescinding that rule just yet, it will, as part of the executive order, rescind a Trump memorandum that required people who were sponsoring their family members for immigration benefits to repay the government if their relatives received public benefits. +
++The executive order also establishes a Task Force on New Americans aimed to facilitate immigrant integration and aims to streamline the naturalization process for the more than 9 million people who are eligible to become US citizens. As part of that, the administration will address the substantial backlog of citizenship applications, assist members of the military stationed abroad with applying for citizenship, and coordinate with state and local governments. +
++
++
++
++Biden and a group of Senate Republicans want two very different Covid-19 relief bills. +
++On Monday, President Joe Biden is getting his first crack at bipartisan negotiations, and met with a group of 10 Senate Republicans on Monday night to see if there is a compromise to be made on the president’s $1.9 trillion Covid-19 relief plan. +
++Biden’s White House has repeatedly said that getting a bipartisan deal done is a top priority. But prolonged negotiations with Republicans, and trying to get to an acceptable middle ground, could complicate both the speed and the boldness of Biden’s first big legislative proposal. +
++There’s a lot of daylight between Biden’s plan and the $618 billion proposal from the Senate Republicans, led by Sen. Susan Collins (R-ME). The GOP proposal is less than half of Biden’s proposed price tag, and pares down or doesn’t include many Democratic priorities. +
++“I am hopeful that we can once again pass a sixth bipartisan Covid relief package,” Collins told reporters following a two-hour meeting at the White House on Monday night. Collins added that while “I wouldn’t say that we came together on a package tonight,” Republicans planned to continue talking with Biden’s team going forward in hopes of reaching an agreement. +
++The fact that there are 10 Republicans behind the plan is significant; with Democrats controlling a Senate split 50-50, these 10 Republican votes could get the proposal past the 60-vote threshold needed to skirt the Senate filibuster in the unlikely situation that the entire Democratic caucus also gets behind it. +
++There are two big questions here. One is whether this group of Republican senators sees their $618 billion figure as the starting point for negotiations with Biden and are willing to go higher, or if it’s where they plan to draw a red line. The other question is whether Biden will bite on what they’re proposing. So far, the White House is indicating the president’s not terribly interested. +
++“There’s obviously a big gap between $600 billion and $1.9 trillion,” White House press secretary Jen Psaki told reporters on Monday. “Clearly, he thinks the package size needs to be closer to what he proposed than smaller.” +
++Biden and Democrats don’t actually need any Republican support to pass his package. They technically can get it through the Senate alone via a process called budget reconciliation. While Biden prepared to meet with the Republicans, House Speaker Nancy Pelosi and Senate Majority Leader Chuck Schumer announced Monday they had filed a joint budget resolution — essentially the first step in the reconciliation process. +
++Biden made bipartisanship one of the hallmarks of his campaign and emphasized it again in his inauguration speech. Republicans argue working with them on a stimulus package would be a good way to prove Biden’s focus on bipartisanship was more than rhetoric. +
++“If they want to get it moving fast, work with us on a bipartisan solution,” Sen. Lisa Murkowski (R-AK), one of the 10 Republicans, told Vox in a recent interview. “And then use your political muscle with reconciliation later on, but at least show evidence of the value of working together.” +
++The White House, however, had repeatedly emphasized that their proposal has broad public support and argued for fast passage of a bold relief bill — which could be delayed by prolonged negotiations. +
++Congressional Democrats believe Republicans are vastly underestimating the amount of money needed to ensure a strong economic recovery — and they point out the GOP has used the reconciliation process before to quickly advance its priorities, including attempting to unravel the Affordable Care Act. +
++The group of 10 Republicans who came up with the $618 billion Covid-19 proposal are led by a few moderates who have seemed eager to negotiate with Biden. But the entire group of senators runs the ideological gamut from moderate to conservative, and includes: +
++It’s important to distinguish this group of Republicans from the bipartisan group of Senate Republicans and Democrats who worked together to propose the framework for a $900 billion Covid-19 relief bill passed back in December. There’s even a newer iteration of that bipartisan group, featuring 16 senators, who have been meeting together to talk about more Covid-19 relief. It’s this 16-senator bipartisan group that has had numerous phone calls with top White House officials, but no face-to-face meetings with Biden himself. +
++Now, some of the Republican members of that group — namely, Collins, Murkowski, Romney, and Cassidy — are forging their own path. And while this new $618 billion Republican counteroffer doesn’t necessarily spell the end of the bipartisan working group in the Senate, it was entirely a GOP-led effort, a Senate Democratic aide told Vox. +
++Psaki told reporters Biden was pleased that there was a Republican group eager to meet with him, but reiterated Biden wouldn’t be making any final decisions about their proposal on Monday. +
++“It’s an exchange of ideas,” Psaki said. “This group sent a letter with some outlines and toplines with their concerns and priorities. What this meeting is not is a forum for the president to make or accept an offer.” +
++The GOP proposal is focused largely on speeding up vaccine distribution, allocating $160 billion to that effort. This largely mirrors Biden’s plan, although the president’s overall vaccine plan is closer to $400 billion, including much more money for school reopenings and building up a health care workforce. +
++Things diverge even more from there. +
++The Republican plan would fund $300 weekly supplemental unemployment insurance through June (Biden’s plan includes $400 weekly unemployment payments through September). The Republican plan has $1,000 stimulus checks, but only for people making a maximum of $50,000 per year as a single person and $100,000 per year as a couple. (Biden’s plan would send $1,400 stimulus checks to everyone making less than $75,000 at an individual level, and $150,000 as a couple — Democrats, who campaigned on this amount, have been adamant it be included in any final bill). +
++A lot of Democrats are wondering whether these Republicans see their $618 billion number as the floor or the ceiling for talks with Biden. Vox reached out to five Republican offices asking whether senators viewed the number as a starting point in negotiations, or if they were going to hold firm to the number. As of press time, no office had responded; in a Friday interview with Vox, however, Murkowski appeared to suggest an openness to going higher. +
++“I want to find a way to be helpful there,” Murkowski told Vox on Friday. “You’ve got a lot of folks that say it’s $1.9 trillion or nothing. Can we agree 80 percent is better than 100 percent? For some, it’s not, and I think that’s some of what we’re seeing right now.” +
++It’s not yet clear how willing Democrats are to take 80 percent in the name of bipartisanship when they could have 100 percent if they push forward alone. But Democratic leaders will still have a chance to weigh in on the matter, the White House said. +
++Biden is meeting with this group of Republican senators at the White House before he has a face-to-face meeting with senior Democratic members of congressional leadership like Pelosi and Schumer, though Psaki noted Biden is in regular communication with those two. +
++“They have been in very close touch with the president directly and members of the senior team,” Psaki told reporters. “There will definitely be Democrats who will be part of conversations here at the White House.” +
++President Biden will either be able to have his $1.9 trillion relief bill passed on a party-line vote, or have bipartisanship. He probably can’t have both. +
++Biden’s White House has repeatedly said he’s open to having a “conversation” about his proposal and is willing to hear “tweaks” and recommendations to improve the bill. What’s less clear is whether the president is willing to lower the scope and ambition of his proposal — especially the $1.9 trillion price tag. +
++“I’m sure they’d be very happy to work with us if we agreed with everything they proposed,” Sen. Mitt Romney told Vox last week. “How willing they are to work with us if we have ideas about taking this apart and having perhaps two pieces of legislation, or perhaps adjusting certain elements, that’s something they would have to respond to.” +
++Already, Biden’s White House has unequivocally said they’re not splitting Biden’s package into multiple pieces. And while Biden may be open to lowering the overall number of his plan, Psaki poured cold water on the idea that he’d lower it all the way to $600 billion — repeatedly saying the president believes there’s more danger in Congress doing too little than too much. +
++There may be room for Biden to meet with Republicans in the middle, but it remains to be seen if both sides are digging in their heels or are ready for some give and take. Republicans have warned that if there’s no room for compromise on Biden’s very first legislative priority, it could spell trouble for negotiations down the line on the president’s upcoming recovery package — which is likely to contain an infrastructure component. +
++“If we move towards reconciliation next week, I wonder what signal that sends to those of us who want to try to advance solutions that might not be 100 percent solutions but are 80 percent solutions,” Murkowski told Vox. +
++Three ways fossil fuel companies try to trick the public. +
++In his first week in office, President Joe Biden committed to an all-of-government approach to tackle climate change, signing executive orders recommitting the US to the Paris climate agreement, pausing new leases for oil and gas companies on federal land, and stating his intention to conserve 30 percent of federal lands by 2030. +
++Yet while Biden’s climate actions have been lauded by many, there are some, often with connections to the fossil fuel industry, who strongly oppose taking stronger action on climate. +
++Many such detractors use common oil-industry talking points in their arguments — talking points that have been developed in collaboration with PR firms and lobbyists to undercut clean energy policies and prolong dependence on fossil fuels. +
++A 2019 report by researchers at George Mason, Harvard University, and the University of Bristol describes how the fossil fuel industry deliberately misled the public by funding climate denial research and campaigns all while knowing for decades that human-induced climate change exists. +
++Aware of the science but afraid of the impacts it might have on their returns, oil executives funded opposition research that “attacked consensus and exaggerated the uncertainties” on the science of climate change for many years with the goal of undermining support for climate action. +
++Their messaging has worked for so long because Big Oil has become really good at stretching the truth. +
++“What’s really important to keep in mind is that part of the reason that oil and gas propaganda is so effective is that there is always a grain of truth to it,” said Genevieve Guenther, the founder of End Climate Silence, an organization that works to promote accurate media coverage of the climate crisis. +
++“I call it ‘sort of true,’ where there’s something about the messaging that’s true, but that grain of truth gets developed into a whole tangle of lies that obscure the real story,” Guenther said. +
++Guenther, originally a professor of Renaissance literature, is also working on a book titled The Language of Climate Change. I spoke with her to get a better understanding of how to recognize — and counter — Big Oil propaganda. +
++As the Biden administration takes important steps to address the climate emergency, the fossil fuel industry and its allies in the media will be ramping up the misinformation campaign to skew public opinion and get in the way of climate policy. Fox News has already started. +
++Which is why it’s more important than ever to be aware of the tools oil and gas companies use to cloud the issue. +
++My conversation with Guenther, edited for length and clarity, is below. +
++I’d like to start with your thoughts on how the Biden administration is handling climate change so far. +
++I think that the Biden administration has come a really long way since the beginning of the [2020] primaries. I think that the Sunrise Movement and Evergreen Action folks, and other activists connected to Alexandria Ocasio-Cortez and Jay Inslee, have done an amazing job, basically schooling Biden on climate. +
++So far, Biden’s the best president on climate that we have had. But I’m not quite ready to do a backflip and wave my pom-poms yet, though, because I know that his major plan, which is to decarbonize the power grid by 2035, will need to be routed in some way through Congress. +
++I am anticipating that’s not going to be easy and expect a massive PR blitz [from the fossil fuel industry], which is going to be timed for the attempt to pass this plan, whether directly or through budget reconciliation. And I worry that the Biden administration, and the climate movement more broadly, might not be ready, +
++So what are the talking points the oil industry uses to try to convince the public in these PR blitzes? +
++People can recognize fossil fuel industry talking points by thinking about what they’re designed to do. In general, fossil fuel talking points are designed to do three things: make people believe that climate action will hurt them, and hurt their pocketbooks in particular; make people think we need fossil fuels; and try to convince us that climate change isn’t such a big deal. +
++How do they make people believe that taking climate action is going to hurt them financially? +
++Right now, they’re really hammering the point that climate action is going to hurt jobs and the economy. So, for instance, Sen. Ted Cruz released a press statement saying that by rejoining the Paris climate accords, Biden is showing that “he’s more interested in the views of the citizens of Paris than in the jobs of the citizens of Pittsburgh.” +
++Yeah, and we also saw Rep. Lauren Boebert make a similar statement saying she works for “the people of Pueblo, not the people of Paris” and that the Paris agreement would put “blue-collar jobs at risk.” +
++Yeah, exactly. So Cruz is arguing that Democrats plan to destroy the jobs they don’t like, including thousands of manufacturing jobs. This is completely false, because building out clean energy infrastructure is going to create millions of manufacturing jobs in this country which can’t be outsourced. +
++And whatever fossil fuel jobs have been lost in the past year happened a) on Trump’s watch, and b) due to market forces that have absolutely nothing to do with any explicit climate policy passed by any administration. +
++So if the claim is untrue, how has the idea that taking action on climate change will cause millions of job losses become so pervasive? +
++There’s a mythology in this country of the coal miner and the oil and gas worker, as the kind of exemplary masculine figure who acts as the backbone of America. +
++Do you think there’s any truth to that? +
++It is true that if we phase out the fossil fuel industry there are going to be people, and indeed whole communities, that will need to find their livelihood in different industries. That is absolutely true. +
++But two things about that: Number one, you can design policies so that those people don’t suffer, and number two, you can put incentives in place so that the new jobs are created in the geographical regions that are already depopulated and suffering economically, because the fossil fuel industry is not actually prosperous enough anymore to sustain a vibrant economy in those regions to begin with. +
++So, you can set up both: policies to ease the transition and policies to incentivize new investment so that the economy ends up more vibrant in these locations than it was before. Nothing is inevitable. The transition can be managed. +
++Okay, so what’s the second talking point oil and gas uses? +
++The second thing oil and gas companies will do is try to make people believe that we need fossil fuels, and that oil and gas companies should stay in business. +
++One I’ve seen a lot lately raises people’s national security fears with the message that we need to extract oil to maintain our “energy independence,” as if domestically produced fossil energy alone were powering America’s homes and businesses. +
++The truth is that, according to the US Energy Information Agency, in 2019 (the latest year for which full data is available) the US imported 9.14 million barrels of petroleum a day — half a million more than we exported. It’s clean, safe energy sources like wind and solar that are sure to be domestically produced, not oil and methane gas. +
++So they act as if US independence will be lost without fossil fuels, while in reality America still depends on other countries to get its oil and gas. Got it. What else? +
++Another talking point designed to make us believe that we need fossil fuels is the message that we cannot halt global warming without “innovation.” This is a tricky one, because you’ll often hear energy researchers talk about the innovations we’ll want to develop in order to enable continued aviation and industrial shipping. +
++But saying that new technologies will help us is different from saying that we need them, which implies that the world cannot stop using fossil fuels now. So politicians in the pockets of the oil and gas producers will proclaim that they support “innovation,” and fossil fuel companies will place ads touting the money they’re spending on research and development— but the money they actually do spend is orders of magnitude smaller than their PR budgets, not to mention their budgets for exploring and developing new fossil fuel reserves. +
++What’s the third big talking point? +
++The third thing Big Oil will try to do is to make people believe that climate change is not such a big deal. Either they call people trying to communicate the dangers of global warming “alarmists,” or they simply don’t talk about the climate crisis at all. +
++In their campaign of silence they’re aided by the vast majority of the broadcast news media, which mostly proceeds as if the crisis didn’t exist and won’t even mention the words “climate change” when they report on floods, fires, and hurricanes in which there are scientifically established links to global warming. +
++It’s weird to think of silence as messaging, but sometimes what you don’t say is as important as what you do. +
++Okay, so we now have the three points the fossil fuel industry often uses: Convince people climate action will hurt their pocketbooks, suggest that we need fossil fuels, and downplay the climate emergency. How do climate scientists, activists, and the media counter that narrative? +
++We’ve got to keep climate change in the foreground of people’s attention. We’ve got to be clear about why we’re making this energy transition — it’s not just because it’s a new way to create jobs, and it’s not just because we like clean air and water. +
++It’s because if we don’t do it, we might actually destroy civilization. +
++We’re not going to change up everything unless we have to, and guess what? We have to. This is what an existential threat means. +
++I worry that the Biden administration isn’t bringing that message to the foreground, because you need that to be part of the understanding of why we’re doing this work. +
++The motivation here is that we’re trying to save our world. We’re trying to save the lives of our children. I think activists do a pretty good job of keeping that messaging in the foreground, but I really wish that politicians would do it too. I think they’re still running scared, and I don’t think they have to be. +
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+Australia’s tour of South Africa postponed due to COVID-19 pandemic - "We look forward to playing the series against CSA at a date to be confirmed in due course," Cricket Australia's interim Chief Executive Nick Hockley said
Olympics will go ahead regardless of COVID-19 situation: Tokyo 2020 president - “We must consider new ways of hosting the Olympics” as a part of that, says Tokyo 2020 President Yoshiro Mori
Rafael Nadal sidelined, team Novak Djokovic wins to open ATP Cup defence - Rafael Nadal issued a statement before his scheduled match against Australia’s Alex De Minaur on Feb. 2 saying he had a stiff lower back and “hopefully I’ll be better for Thursday”
Power to relax provisions of Sports Code will be with government: Ministry circular - The Sports Ministry will have the power to relax provisions of the National Sports Development Code while deciding on grant of recognition to federat
Liverpool fills injury-hit defense with deadline day deals - Ben Davies and Ozan Kabak were identified by the English champion as stop-gap measures for the second half of the season.
Intach alarm over damage to Odisha heritage amid ‘beautification’ drive - Act on preservation of ancient monuments violated, structures damaged around Lingaraj temple
Conserving a glimpse of State’s political history - Nearly 3,000 cartographs in the possession of Archives dept. to be digitised by Keralam Museum
Directive to private temples - Chikkamagaluru Assistant Commissioner H.L. Nagaraj has said all temples, other than those under the Muzrai Department, have to register with the admin
Tamil Nadu Governor's address hopeful of economic recovery - Mr. Purohit's announcement was in line with the recommendations made by a high-level expert committee led by former Reserve Bank of India Governor C. Rangarajan
Gauhati HC to decide fate of 7 Nagaland MLAs on February 8 - The NPF legislators defied party decision to back Congress candidate in 2019 Lok Sabha elections
Navalny: More than 200 held as court considers jailing Putin critic - A Moscow court is deciding whether Putin critic Alexei Navalny will go to jail for years.
Turkey's Erdogan denounces LGBT youth as police arrest students - President Erdogan denounces the LGBT movement as police arrest students demonstrating in Istanbul.
Spain's vaccine delays hamper fight against pandemic - Officials fear the delays mean the impact of vaccines will not be felt till the end of 2021.
Is Russia targeting CIA spies with secret weapons? - Ex-CIA officer Marc Polymeropoulos believes he was targeted while on a visit to Moscow.
Brexit: Animal-based food checks at ports suspended - Arlene Foster denounces "threats" against staff checking on animal and food products at Larne and Belfast.
Flash is dead—but South Africa didn’t get the memo - Adobe: you can't use Flash in 2021. South Africa: watch me! - link
Hackers are exploiting a critical zero-day in devices from SonicWall - "Highly sophisticated threat actors" exploit flaws in coordinated attack on SonicWall. - link
Media frenzy, skepticism engulf virus origin probe—and WHO is over it - It's "time for people who say and think they have information to start providing it.” - link
We’re getting a Wakanda spinoff series from Ryan Coogler on Disney+ - It's part of a 5-year exclusive TV development deal for the Black Panther director. - link
Apple rolls out macOS Big Sur 11.2 with bug fixes and Bluetooth tweaks - macOS update comes a week after updates to iOS, iPadOS, tvOS, and watchOS. - link
+10+10=twenty 11+11=twenty too +
+ submitted by /u/sweetsformysweets
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+I said, "Tell him, he's bloody good. I don't have any kids” +
+ submitted by /u/KeybladeMaster1994
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+They were all sitting on a bench in a mental institution. "Let's have sex with a cat?" asked the zoophile. "Let's have sex with the cat and then torture it," says the sadist. "Let's have sex with the cat, torture it and then kill it," shouted the murderer. "Let's have sex with the cat, torture it, kill it and then have sex with it again," said the necrophile. "Let's have sex with the cat, torture it, kill it, have sex with it again and then burn it," said the pyromaniac. There was silence, and then the masochist said: "Meow." +
+ submitted by /u/SoulSp34r
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+The first says, "My son is so successful, he's VP of his company and just gave his best friend a car. " +
++The second says, " That's nothing, my son is CEO of his company and just gave his best friend a house." +
++The third says, "Well, my son owns 3 highly profitable companies and just gave his best friend a jet." +
++They look expectantly at the last guy who says, "My son is a gay escort who gets showered with love and admiration. He just got a car, a house, and a jet from three of his clients." +
+ submitted by /u/chdfbjffgkk
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+This guy is not your man.
This guy is Mark Zuckerberg.
+
submitted by /u/aquarianfin
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