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+ + + ++We developed a COVID-19 transmission model used as part of RAND9s web-based COVID-19 decision support tool that compares the effects of nonpharmaceutical public health interventions (NPIs) on health and economic outcomes. An interdisciplinary approach informed the selection and use of multiple NPIs, combining quantitative modeling of the health/economic impacts of interventions with qualitative assessments of other important considerations (e.g., cost, ease of implementation, equity). This paper provides further details of our model, describes extensions, presents sensitivity analyses, and analyzes strategies that periodically switch between a base NPI level and a higher NPI level. We find that a periodic strategy, if implemented with perfect compliance, could have produced similar health outcomes as static strategies but might have produced better outcomes when considering other measures of social welfare. Our findings suggest that there are opportunities to shape the tradeoffs between economic and health outcomes by carefully evaluating a more comprehensive range of reopening policies. +
++How do we forecast an emerging pandemic in real time in a purely data-driven manner? How to leverage rich heterogeneous data based on various signals such as mobility, testing, and/or disease exposure for forecasting? How to handle noisy data and generate uncertainties in the forecast? In this paper, we present DeepCOVID, an operational deep learning framework designed for real-time COVID-19 forecasting. DeepCOVID works well with sparse data and can handle noisy heterogeneous data signals by propagating the uncertainty from the data in a principled manner resulting in meaningful uncertainties in the forecast. The deployed framework also consists of modules for both real-time and retrospective exploratory analysis to enable interpretation of the forecasts. Results from real-time predictions (featured on the CDC website and FiveThirtyEight.com) since April 2020 indicates that our approach is competitive among the methods in the COVID-19 Forecast Hub, especially for short-term predictions. +
++The new SARS-CoV-2 variant B.1.1.7 was identified in December 2020 in the South-East of England, and rapidly increased in frequency and geographic spread. While there is some evidence for increased transmissibility of this variant, it is not known if the new variant presents with variation in symptoms or disease course, or if previously infected individuals may become reinfected with the new variant. Using longitudinal symptom and test reports of 36,920 users of the Covid Symptom Study app testing positive for COVID-19 between 28 September and 27 December 2020, we examined the association between the regional proportion of B.1.1.7 and reported symptoms, disease course, rates of reinfection, and transmissibility. We found no evidence for changes in reported symptoms, disease severity and disease duration associated with B.1.1.7. We found a likely reinfection rate of around 0.7% (95% CI 0.6-0.8), but no evidence that this was higher compared to older strains. We found an increase in R(t) by a factor of 1.35 (95% CI 1.02-1.69). Despite this, we found that regional and national lockdowns have reduced R(t) below 1 in regions with very high proportions of B.1.1.7. +
++Since the end of 2020, the COVID-19 pandemic has experienced a major turning point with the appearance and rapid spread of new variants, causing a significant increase in the number of new cases requiring hospitalization. These so-called UK, South African or Brazilian variants are characterized by combinations of mutations which allow them to be distinguished from the variants which have circulated since the start of the epidemic. The impact of these variants on the functioning of healthcare systems requires monitoring the spread of these variants, which are more contagious, more lethal and may reinfect people who are already immune to a natural infection or to a vaccination. Monitoring the viral genome in wastewater has shown great value in early detection of the dynamics of virus spreading in populations. The sequencing of viral genomes is used in humans, but its application and interpretation on wastewater matrices are much more complex due to the diversity of circulating strains. Also this study demonstrates the possibility of following certain mutations found in these new variants by targeted RT-qPCR. This study is the first carried out in France demonstrating the spreading dynamics of the 69-70 deletion in the Spike protein of SARS-CoV-2. +
++New COVID-19 diagnoses have dropped faster than expected in the United States. Interpretations of the decrease have focused on changing factors (e.g. mask-wearing, vaccines, etc.), but predictive models largely ignore heterogeneity in behaviorally-driven exposure risks among distinct groups. We present a simplified compartmental model with differential mixing in two behaviorally distinct groups. We show how homophily in behavior, risk, and exposure can lead to early peaks and rapid declines that critically do not signal the end of the outbreak. Instead, higher exposure risk groups may more rapidly exhaust available susceptibles while the lower risk group are still in a (slower) growth phase of their outbreak curve. This simplified model demonstrates that complex incidence curves, such as those currently seen in the US, can be generated without changes to fundamental drivers of disease dynamics. Correct interpretation of incidence curves will be critical for policy decisions to effectively manage the pandemic. +
++Importance Individuals with pre-existing mental illness may be particularly vulnerable to the negative impact that the coronavirus disease 2019 (COVID-19) pandemic seems to have on mental health. Most prior studies on this topic are limited by non-random sampling, lacking information on non-respondents, and self-reporting of mental illness. In the present study, we aimed to overcome these limitations via random sampling, acquisition of clinical and sociodemographic data on both respondents and non-respondents, and weighting of results informed by attrition. Objective To assess whether patients with mental illness experienced deterioration in mental health during the nationwide COVID-19 lockdown of Denmark in the Spring of 2020. Design A cross-sectional, questionnaire-based survey coupled with sociodemographic and clinical data from the medical records of all invitees. The latter enabled analysis of attrition and weighting of results. Setting The psychiatric services of the Central Denmark Region. Participants A total of 992 randomly drawn patients diagnosed with mental illness in the psychiatric services of the Central Denmark Region prior to the lockdown responded to the online survey (response rate of 21.6%). Exposure The four-week nationwide lockdown during the COVID-19 pandemic (from March 11 to April 15, 2020). Main Outcomes and Measures The online questionnaire included the 18-item Brief Symptom Inventory (BSI-18), the five-item World Health Organization Well-Being Index (WHO-5), and 14 questions evaluating worsening or improvement in symptoms during the lockdown using the pre-pandemic period as reference. Perceived reasons for deterioration of mental health were also reported. Results The weighted mean WHO-5 and BSI-18 scores were 38 and 28, respectively. A total of 52% of the respondents reported that their mental health had deteriorated during the lockdown, while 33% reported no change, and 16% reported improvement. The most commonly reported reasons for deterioration were loneliness, disruption of routines, concerns about coronavirus, less frequent contact with family/friends, boredom, and reduced access to psychiatric care. Conclusion and Relevance More than half of the patients with mental illness reported worsening of their mental health during the pandemic lockdown. There should be increased emphasis on ensuring both social and clinical support for individuals with mental illness during pandemics. +
++SARS-CoV-2 variants raise concern regarding the mortality caused by COVID-19 epidemics. We analyse 88,375 cycle amplification (Ct) values from variant-specific RT-PCR tests performed between January 26 and March 13, 2021. We estimate that on March 12, nearly 85% of the infections were caused by the V1 variant and that its transmission advantage over wild type strains was between 38 and 44%. We also find that tests positive for V1 and V2/V3 variants exhibit significantly lower cycle threshold (Ct) values. +
++Background: The COVID-19 pandemic has deeply affected medical practice, and changes in healthcare activities were needed to minimize the overload and avoid healthcare systems collapse. The aim of this study was to evaluate the impact of the pandemic on surgical procedures in Brazil. Materials and Methods: We conducted a descriptive study of the number of hospitalizations for surgical procedures in Brazil from 2016 to 2020. Data were collected from the Brazilian Department of Informatics of the Unified Health System (DATASUS). Analyzes were performed according to the type of procedure, geographical region, subgroups of surgical procedures, and the number of surgeries from 2020 were compared with the average from 2016 to 2019. Results: There were 4,009,116 hospitalizations for surgical procedures in the Brazilian Public Health System in 2020. When comparing it to the average of hospitalizations from 2016-2019, there was a decrease of 14.88% [95%IC (14.82-14.93)]. Decrease rates were 34.82% [95%IC (34.73-34.90)] for elective procedures and 1.11% [95%IC (1.07-1.13)] for urgent procedures. Decrease rates were similar in all the five regions of the country (average 14.17%). Surgical procedure subgroups with the highest decrease rates were endocrine gland surgery (48.03%), breast surgery (40.68%), oral and maxillofacial surgery (37.03%), surgery of the upper airways, face, head and neck (36.06%), and minor surgeries and surgeries of skin, subcutaneous tissue and mucosa (33.16%). Conclusion: The overload of healthcare facilities has demanded a reduction of non-urgent activities to prevent a collapse of healthcare systems, resulting in a decrease in elective surgeries. Recommendations about the performance of surgical procedures were made, and continuous refinements of these recommendations are encouraged. +
++In this exploratory study, we scrutinize a database of over one million tweets collected from March to July 2020 to illustrate public attitudes towards mask usage during the COVID-19 pandemic. We employ natural language processing, clustering and sentiment analysis techniques to organize tweets relating to mask-wearing into high-level themes, then relay narratives for each theme using automatic text summarization. In recent months, a body of literature has highlighted the robustness of trends in online activity as proxies for the sociological impact of COVID-19. We find that topic clustering based on mask-related Twitter data offers revealing insights into societal perceptions of COVID-19 and techniques for its prevention. We observe that the volume and polarity of mask-related tweets has greatly increased. Importantly, the analysis pipeline presented may be leveraged by the health community for qualitative assessment of public response to health intervention techniques in real time. +
+Safety and Tolerability of Emricasan in Symptomatic Outpatients Diagnosed With Mild-COVID-19 - Condition: Covid19
Interventions: Drug: Emricasan; Other: Placebo
Sponsor: Histogen
Recruiting
Efficacy of Reinforcing Standard Therapy in COVID-19 Patients With Repeated Transfusion of Convalescent Plasma - Condition: Covid19
Interventions: Other: Convalescent Plasma with antibody against SARS-CoV-2.; Other: Standard treatment for COVID-19
Sponsors: Hospital Son Llatzer; Fundació d’investigació Sanitària de les Illes Balears
Recruiting
Diagnostic Performance of the ID Now™ COVID-19 Screening Test Versus Simplexa™ COVID-19 Direct Assay - Condition: Covid19
Intervention: Diagnostic Test: ID Now™ COVID-19 Screening Test
Sponsor: Groupe Hospitalier Paris Saint Joseph
Active, not recruiting
Off-the-shelf NK Cells (KDS-1000) as Immunotherapy for COVID-19 - Condition: Covid19
Interventions: Biological: KDS-1000; Other: Placebo
Sponsor: Kiadis Pharma
Not yet recruiting
Corticosteroids for COVID-19 - Condition: Covid19
Interventions: Drug: Prednisone; Device: Point of Care testing device for C-reactive protein
Sponsor: University of Alberta
Not yet recruiting
Effects of Telerehabilitation After Discharge in COVID-19 Survivors - Condition: Covid19
Intervention: Other: Telerehabilitation
Sponsor: Hacettepe University
Recruiting
A Study to Assess if a Medicine Called Bamlanivimab is Safe and Effective in Reducing Hospitalization Due to COVID-19 - Condition: Covid19
Interventions: Biological: Bamlanivimab; Other: Standard of Care
Sponsors: Fraser Health; Fraser Health Authrority Department of Evaluation and Research Services; Surrey Memorial Hospital Clinical Research Unit; Centre for Health Evaluation and Outcome Sciences; Surrey Hospitals Foundation; BC Support Unit; University of British Columbia; Ministry of Health, British Columbia
Not yet recruiting
Efficacy of Adaptogens in Patients With Long COVID-19 - Condition: Covid19
Interventions: Dietary Supplement: ADAPT-232 oral solution; Other: Placebo oral solution
Sponsors: Swedish Herbal Institute AB; National Family Medicine Training Centre, Georgia; Tbilisi State Medical University; Phytomed AB
Not yet recruiting
COVID-19 Self-Testing Through Rapid Network Distribution - Condition: Covid19
Interventions: Behavioral: COVID-19 self-test; Behavioral: COVID-19 test referral
Sponsors: University of Pennsylvania; Public Health Management Corporation
Not yet recruiting
Effectiveness of the Adsorbed Vaccine COVID-19 (Coronavac) Among Education and Public Safety Workers With Risk Factors for Severity - Condition: Covid19
Intervention: Biological: Adsorbed SARS-CoV-2 (inactivated) vaccine
Sponsors: Fundação de Medicina Tropical Dr. Heitor Vieira Dourado; Butantan Institute
Not yet recruiting
Text-based Reminders to Promote COVID-19 Vaccinations - Condition: Covid19, Vaccines
Interventions: Behavioral: Self-benefit; Behavioral: Prosocial-benefit; Behavioral: Early access; Behavioral: Fresh start
Sponsors: University of California, Los Angeles; Carnegie Mellon University
Recruiting
Text-based Interventions to Promote COVID-19 Vaccinations - Condition: Covid19, Vaccines
Interventions: Behavioral: Patient MyChart Scheduling Link; Behavioral: Patient Educational Video; Behavioral: Enhanced Follow through Message
Sponsors: University of California, Los Angeles; Carnegie Mellon University
Recruiting
Vitamin D3 Levels in COVID-19 Outpatients From Western Mexico - Condition: Covid19
Intervention: Dietary Supplement: Vitamin D3
Sponsor: University of Guadalajara
Completed
HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID) - Condition: Covid19
Interventions: Drug: Apixaban; Drug: Atorvastatin
Sponsors: Cambridge University Hospitals NHS Foundation Trust; University of Liverpool; Cambridge University Hospitals NHS Foundation Trust (joint Sponsor); The University of Cambridge (joint Sponsor)
Not yet recruiting
Ultrasound Neural and Immunomodulation Treatment Evaluation Study for COVID-19 - Condition: Covid19
Intervention: Device: Splenic Ultrasound
Sponsors: Imanuel Lerman; SecondWave Systems Inc.; United States Department of Defense; University of Minnesota
Recruiting
Zinc supplementation as an adjunct therapy for COVID-19: challenges and opportunities - An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. Patients with COVID-19 are at risk of cytokine storm, acute respiratory distress syndrome (ARDS), reduced blood oxygenation, mechanical ventilation, and a high death rate. Although recent studies have shown remdesivir & dexamethasone as treatment options, there is an urgent need to find a treatment to inhibit virus replication and to control the progression…
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection - SARS-CoV-2 is a respiratory pathogen and primarily infects the airway epithelium. As our knowledge about innate immune factors of the respiratory tract against SARS-CoV-2 is limited, we generated and screened a peptide/protein library derived from bronchoalveolar lavage for inhibitors of SARS-CoV-2 spike-driven entry. Analysis of antiviral fractions revealed the presence of α(1)-antitrypsin (α(1)AT), a highly abundant circulating serine protease inhibitor. Here, we report that α(1)AT inhibits…
Messenger RNA vaccines against SARS-CoV-2 - The first two vaccines proven to be effective for inhibiting COVID-19 illness were both mRNA, achieving 95% efficacy (and safety) among 74,000 participants (half receiving placebo) after intramuscular delivery of two shots, 3-4 weeks apart. To view this Bench to Bedside, open or download the PDF.
What Do Influenza and COVID-19 Represent for Patients With Inflammatory Bowel Disease? - CONCLUSIONS: Once the cytokine storm observed in influenza and COVID-19 is similar to the cytokine pattern observed in IBD patients during the disease flares, the advice is that avoiding the infections is still an optimal option for IBD subjects.
Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model - CONCLUSION: In conclusion, this study provided experimental validation for computational insight into the potential of withanone as a potent inhibitor of SARS-CoV-2 coronavirus entry into the host cells.
Artificial Intelligence for COVID-19 Drug Discovery and Vaccine Development - SARS-COV-2 has roused the scientific community with a call to action to combat the growing pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved vaccines available for deployment as a frontline defense. Understanding the pathobiology of COVID-19 could aid scientists in their discovery of potent antivirals by elucidating unexplored viral pathways. One method for accomplishing this is the leveraging of computational methods to discover new candidate drugs…
Evaluation of Annona muricata Acetogenins as Potential Anti-SARS-CoV-2 Agents Through Computational Approaches - Annona muricata, a tropical plant which has been extensively used in ethnomedicine to treat a wide range of diseases, from malaria to cancer. Interestingly, this plant has been reported to demonstrate significant antiviral properties against the human immunodeficiency virus, herpes simplex virus, human papilloma virus, hepatitis C virus and dengue virus. Additionally, the bioactive compounds responsible for antiviral efficacy have also shown to be selectively cytotoxic while inhibiting…
Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2 - CONCLUSION: COVID-19 convalescent patients have SARS-CoV-2-specific antibodies and MBCs, the specificities of which can be defined with short peptides. Epitope-specific antibodies synergistically block RBD-ACE2 interaction.
Imaging features of COVID-19: What we can learn from SARS and MERS (Review) - Coronavirus disease 2019 (COVID-19) is a highly infectious type of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that has rapidly become a global pandemic. COVID-19, SARS and Middle East respiratory syndrome (MERS) are all caused by members of the Coronaviridae family. As expected, emerging genetic and clinical evidence from patients with COVID-19 has indicated that the pathway of infection is similar to that of SARS and MERS. Additionally, much like SARS and…
Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Experimental Validation - The global pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is threatening the health and economic systems worldwide. Despite the enormous efforts of scientists and clinicians around the world, there is still no drug or vaccine available worldwide for the treatment and prevention of the infection. A rapid strategy for the identification of new treatments is based on repurposing existing clinically approved drugs that show antiviral activity against…
Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection - The ongoing COVID-19 pandemic worldwide necessitates the development of therapeutics against SARS-CoV-2. ACE2 is the main receptor of SARS-CoV-2 S1 and mediates viral entry into host cells. Herein, membrane nanoparticles (NPs) prepared from ACE2-rich cells were discovered to have potent capacity to block SARS-CoV-2 infection. The membranes of human embryonic kidney-239T cells highly expressing ACE2 were applied to prepare NPs using an extrusion method. The nanomaterials, termed ACE2-NPs,…
Antiretroviral drug activity and potential for pre-exposure prophylaxis against COVID-19 and HIV infection - COVID-19 is the disease caused by SARS-CoV-2 which has led to 2,643,000 deaths worldwide, a number which is rapidly increasing. Urgent studies to identify new antiviral drugs, repurpose existing drugs, or identify drugs that can target the overactive immune response are ongoing. Antiretroviral drugs (ARVs) have been tested in past human coronavirus infections, and also against SARS-CoV-2, but a trial of lopinavir and ritonavir failed to show any clinical benefit in COVID-19. However, there is…
Discovery of Clioquinol and analogues as novel inhibitors of Severe Acute Respiratory Syndrome Coronavirus 2 infection, ACE2 and ACE2 - Spike protein interaction in vitro - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent for coronavirus disease 2019 (COVID-19), has resulted in an ongoing pandemic. Presently, there are no clinically approved drugs for COVID-19. Hence, there is an urgent need to accelerate the development of effective antivirals. Herein, we discovered Clioquinol (5-chloro-7-iodo-8-quinolinol (CLQ)), a Food and Drug Administration (FDA) approved drug, and two of its analogues (7-bromo-5-chloro-8-hydroxyquinoline…
Nano-formulation of herbo-mineral alternative medicine from linga chenduram and evaluation of antiviral efficacy - Traditional medicine is becoming a primary source of health care in many countries in recent years. The current study proposes a new dimension of understanding a traditional origin treatment, using herbo-mineral preparations in nanoform. The herbo-mineral preparation, Linga chenduram [HMLC], was prepared according to the ancient palm script protocol dates back to 1000 years. In search of alternative therapy for the coronavirus, an attempt was made to determine this ethnic medicine formulation’s…
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies - Neutralizing monoclonal antibodies (nAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represent promising candidates for clinical intervention against coronavirus disease 2019 (COVID-19). We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain (RBD) of the viral spike (S) protein and the receptor angiotensin converting enzyme 2 (ACE2). However, the structural basis for their potent…
Peptides and their use in diagnosis of SARS-CoV-2 infection - - link
A PROCESS FOR SUCCESSFUL MANAGEMENT OF COVID 19 POSITIVE PATIENTS - - link
Sars-CoV-2 vaccine antigens - - link
SARS-COV-2 BINDING PROTEINS - - link
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Ein Bildschirmgerät mit verbesserter Wirkung bei der Befestigung von UV-Entkeimungslampen, umfassend: ein Bildschirmgerät, das einen Umfang hat; eine UV-Entkeimungslampe, die sich am Umfang des Bildschirmgeräts befindet; eine Stromquelle, die elektrisch mit der UV-Entkeimungslampe verbunden ist; eine Steuerschaltung, die elektrisch mit der UV-Entkeimungslampe verbunden ist; und eine Befestigungsvorrichtung, durch die die UV-Entkeimungslampe am Umfang des Bildschirmgeräts befestigbar ist, wobei die Befestigungsvorrichtung einen Sitzkörper, eine erste Klemmplatte und eine zweite Klemmplatte aufweist, wobei der Sitzkörper mit der UV-Entkeimungslampe versehen ist, wobei die erste Klemmplatte und die zweite Klemmplatte beabstandet am Sitzkörper gleitbar angeordnet sind, wodurch ein Klemmabstand zwischen der ersten Klemmplatte und der zweiten Klemmplatte besteht, wobei ein elastisches Element zwischen der zweiten Klemmplatte und dem Sitzkörper angeordnet ist, um die zweite Klemmplatte dazu zu zwingen, sich der ersten Klemmplatte zu nähern.
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Schublade mit antiepidemischer Wirkung, mit einem Schrank (1); mindestens einer Schublade (2), die in dem Schrank (1) angeordnet ist, wobei jede Schublade (2) einen Schubladenraum (25) aufweist; einer UV-Sterilisationsvorrichtung (3), die an der Schublade (2) angeordnet ist; einer Stromquelle (4), die elektrisch mit der UV-Sterilisationsvorrichtung (3) verbunden ist; einer Steuerschaltung (5), die elektrisch mit der Stromquelle (4) und der UV-Sterilisationsvorrichtung (3) verbunden ist; und einem Sensor (6), der elektrisch mit der Steuerschaltung (5) verbunden ist.
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Lüftungssystem für einen mit öffnbaren Fenstern (16) ausgestatteten Gebäuderaum, gekennzeichnet dadurch, dass es ein Gehäuse (18) und einen Ventilator (20) aufweist, wobei durch das Gehäuse eine vom Ventilator erzeugte Luftströmung strömen kann, wobei das Gehäuse dafür eine Einströmöffnung (24) für Luft und eine Ausströmöffnung (22) für Luft enthält, wobei eine der beiden Öffnungen der Form eines Öffnungsspalts (26) zwischen einem Fensterflügel (12) und einem Blendrahmen (14) des Fensters (16) angepasst ist.
X射线图像识别方法、装置、计算机设备及存储介质 - 本申请涉及一种X射线图像识别方法、装置、计算机设备和存储介质。通过获取X射线图像,将X射线图像作为训练样本;构建多注意力交互网络,多注意力交互网络包括卷积批处理标准化网络、特征提取网络和输出网络;其中特征提取网络包括多注意力交互特征提取模块和批标准化模块,特征提取网络通过学习通道之间的相关性,多通道之间的信息交互来达到增强模型的识别能力。利用训练样本对多注意力交互网络进行训练,得到X射线图像识别模型;获取待测X射线图像;将待测X射线图像输入到X射线图像识别模型中,得到X射线图像的类别。本方法减少了网络的参数量和计算量,提高了模型的泛化能力。 - link
利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法 - 本发明提供一种利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法,包括:1)构建新冠病毒核衣壳蛋白(N蛋白)重组表达载体;2)用重组表达载体转染HEK293细胞;3)体外培养细胞,从培养上清中分离纯化N蛋白。利用HEK293表达系统可在短时间内获得大量新冠病毒N蛋白,通过一步亲和层析法可获得纯度高达98%以上的N蛋白。与大肠杆菌相比,采用HEK293表达系统制备的N蛋白在与抗体的结合活性及新冠抗体胶体金检测方面均表现出极大优势,且HEK293表达系统制备的N蛋白其蛋白空间构象接近于病毒N基因在宿主体内的蛋白表达构象,具有更高的免疫诊断和抗体制备的准确性,将其用于制作诊断试剂和疫苗前景广阔。 - link
Compositions and methods for detecting SARS-CoV-2 spike protein - - link
The Atlanta Shooting and the Dehumanizing of Asian Women - To live through this period as an Asian-American is to feel trapped in an American tragedy while being denied the legitimacy of being an American. - link
The Alabama Workers Trying to Unionize an Amazon Fulfillment Center - South of Birmingham, warehouse employees are voting on whether to form a union. Their decision could have ripple effects around the country. - link
How Biden Rattled Putin - All it seems to take is to say something that’s true. - link
Garland Is the Last, Best Chance to Uncover Trump’s Role on January 6th - The ongoing federal criminal inquiry is the most promising route to the truth. - link
Reeducated - A virtual-reality documentary takes viewers inside Xinjiang’s secret detention camps for Uighurs and other predominantly Muslim minorities. - link
+A conversation with Heather McGhee about the costs of America’s racial bargain. +
++Black Americans are typically cast as the victims of racism. And indeed, they are victims of America’s long history of racial oppression. +
++But according to Heather McGhee, that fact can obscure an important truth: White Americans also pay a tremendous price for the country’s racial hierarchy — and many don’t even realize it. It’s a self-inflicted wound that will never heal unless Americans change the way they think about race and the national project. +
++McGhee is the former president of the think tank Demos and the author of a terrific new book called The Sum of Us. The story McGhee tells orbits around a depressing metaphor: the drained swimming pool. For a good chunk of the 20th century, American towns offered grand community swimming pools as symbols of leisure and civic pride. They were testaments to public investment. +
++But then desegregation happened and the pools had to be integrated. Rather than open them up to everyone, town after town simply shut them down. And not only did they close the pools, they nuked their parks departments and effectively abandoned public investment altogether. So in the end, Black Americans didn’t get to enjoy the pools, but neither did white people who were motivated by self-destructive racist ideologies. +
++This, McGhee argues, is the story of American politics in microcosm. The entire country is now one giant drained pool. Too many Americans have too easily accepted the lie animating so much of our history, namely that politics is a zero-sum contest in which one group’s gain must be another group’s loss. +
++I wanted to talk through the consequences of all this with McGhee. If she’s right that “We can’t have nice things” because of this lie at the center of our shared story, then how do we transcend that lie? What story must replace it? And how can the left do a better job at persuading the white victims of this lie to let it go? +
++You can hear our entire conversation in the week’s episode of Vox Conversations. A transcript, edited for length and clarity, follows. +
++Subscribe to Vox Conversations on Apple Podcasts, Google Podcasts, Spotify, Stitcher, or wherever you listen to podcasts. +
++How did you come to write this book? +
++One of the first stops on my book journey to write The Sum of Us was Montgomery, Alabama, which is one of many places where there is a beautiful central park in the city. I walked the grounds, this big, wide flat expanse that used to have one of the nearly 2,000 publicly funded grand-resort-style swimming pools in America. And this was something that was a big feature of American life under the New Deal in the 1930s and ’40s and ’50s. It was just one of the many examples of a commitment to the public good by our government that was really supported by white public opinion at the time. +
++But like so much of the New Deal, so much of that public commitment to public goods, there was an asterisk. Public pools in many parts of the country were segregated or for whites only. Certainly this one in Montgomery, Alabama, was. And so in the 1950s and ’60s, when Black families began to win court cases saying, “Hey, those are our tax dollars too. Our families should be able to swim too,” instead of integrating the pools, many cities across the country drained their public pools rather than integrate them. +
++That’s what happened in Montgomery, Alabama. In fact, they drained the pool, filled it with dirt, and closed Oak Park. They sold off the animals in the zoo, shut down the entire parks and recreation department of the city, and kept it closed for a decade. They were almost to 1970 before the good people of Montgomery even got to enjoy a public park again, all because of racism. +
++And to me, that’s such an example of the zero-sum thinking creating costs for everyone, turning what was a public good into a private luxury, expressing the limits of white support for public goods once those public goods were extended and available to people that they did not perceive to be good, that they had been taught for generations to disdain and distrust. +
++In many ways, that’s what’s happened to our entire economy, as the majority of white voters went from supporting a job guarantee and a minimum income in the country in the late ’50s and early ’60s, to that support cratering once the civil rights movement made clear that those kinds of economic guarantees would go to Black people as well. +
++That’s got to be one of the greatest and most consequential political tantrums in history. +
++It is. But throughout the book, I really try to put myself in the shoes of people who might, because of the stories they’d been told, because of what they believe, fit that into their moral understanding. And the more you do that, the more you recognize that in many ways, we’re still there. +
++Those beliefs about the inherent goodness or deservingness of people at the bottom of the economic ladder are still pretty stubborn. And they’re reflected in the majority of white people’s opinions about what a minimum-wage worker should be paid, for example. Or who should pay taxes. Or what kinds of floors we should have under the human misery of our fellow American. +
++Your book opens with a familiar question: Why can’t we have nice things? What nice things can’t we have? +
++I don’t mean self-driving cars or laundry that does itself. I mean things like truly universal affordable health care, or world-class, or even just reliable, modern infrastructure. I mean a public health system to tackle pandemics with efficiency and scale. I mean a well-funded school in every neighborhood. I mean a representative functioning democracy that allows majoritarian views on big public questions to prevail and not get stymied in arcane Senate rules. +
++These are the kinds of things that a wealthy, modern government should be able to provide for its people. And they are the types of things that this country has really failed to deliver on for all of my lifetime, and certainly for the past few generations. +
++A big reason — maybe the biggest reason — for this is that Americans have internalized a story about how politics works and who deserves the privileges of citizenship. You call it a “zero-sum” story. What does that mean? +
++The zero-sum story is the idea that there’s this massive dividing line between Black people and white people, that they’re on opposite teams, and that progress for people of color has to come at white people’s expense. It’s a story that’s still with us because it’s very profitable. Because the upshot of selling this story is that white voters cheer the destruction of supports that could benefit them if it will keep the people on the opposite team from having something that they don’t think they deserve. +
++So what that has meant in practical politics has been the kind of zero-sum rhetoric that we hear from the right wing: the makers and takers, the taxpayers and freeloaders, the free stuff, the handouts, us versus them. +
++We’re all products of deep cultural forces that shape us in ways we don’t understand and our identities are getting pushed and activated in ways we don’t recognize. How do you make someone aware of the illusoriness of their own identity, of their own story, without also offending who they think they are? +
++I think politics has a role. It’s really important that we do political messaging like the Race Class Narrative project that I co-developed and we housed at Demos, which was aimed at better messages for organizers and activists and candidates to beat the zero-sum scapegoating story. That’s really important. +
++But I met lots of white people over the course of working on this book who had actually rejected the zero-sum after growing up being steeped in it. It wasn’t because they heard the magic words in a campaign ad. It was because they had rolled up their sleeves in organizing. They had actually experienced what it’s like to trust someone who also needed the same change in their own lives. +
++If I was among the richest and most powerful people in this country and I wanted to construct a pair of competing ideologies that would ensure my interests are never threatened, what we have now is what it would be: conventional white racism on the one side and what you see in some corners of the left now, which is a blanket condemnation of white privilege, or an obsession with various symbolic battles. +
++As you know better than anyone, if these are the terms, solidarity is unachievable and the whole plutocratic system keeps spinning. +
++I definitely think there’s a disconnect here between the way progressive actors with microphones elevate issues on Twitter and in news coverage, and the real concerns of, say, a Black family in St. Louis. So there’s a distortion of the causes of racial justice because of the white predominance in the chattering class on the left. It’s almost like white supremacy within the activist movement is hurting the activist movement’s cause. +
++My eyes were really opened to this when it comes to the role of race and racism in the environmental movement. If you’re just a casual observer, you might think that your typical environmentalist is a white guy with a fleece and a backpack, right? That’s Sierra Club, that’s the REI version of the environmentalist. It’s the upper-class family that recycles a lot and composts. That’s who’s most active on environmental issues — or at least that’s the stereotype. And it’s also because those groups are the best funded and also influential in policymaking. +
++But when I dug into it, it turns out that white people are much less worried about climate change and supportive of taking action than Black and brown people are. So your average environmentalist, as in someone who really cares about the environment and is really supportive of taking pretty aggressive action to address this existential threat, is a Black or brown person, not an upper-class white person. So that kind of white privileging within the ranks of the movement is actually cutting off the leadership’s connection to the people who are the natural base. +
++Your book makes the incredibly important argument that racism hurts everyone, and yet what I hear over and over again from white people I engage with where I live (in the Deep South) is resentment over the notion that they’re “privileged” or tools of white supremacy. Just setting aside the merits of any of those arguments and why they’re elevated (which you just explained), the practical issue here is that these narratives function like conversation-stoppers and it’s the kind of thing I know you bump up against all the time. +
++You know, it’s funny because the white share of the vote to the right wing has been pretty consistent ever since Lyndon Johnson signed the Civil Rights and Voting Rights Act. So this new tendency to blame white allegiance to the GOP on the recent resurgence of racial justice in the national conversation feels a little hollow to me. Because it’s not like there were all these white people who were Democrats until the protests in Ferguson happened in 2014. It’s definitely made the dog whistles into bull horns, and it’s given a lot of fodder to Fox News and right-wing radio to harp on racial grievances. +
++But the long-term data is pretty consistent on this stuff. The majority of white moderates and conservatives say that Black people take more from society than we give. That’s not necessarily about Dr. Seuss books. This is a deeper and older projection that feels very necessary to justify the racial hierarchy. +
++The kinder, gentler version of this is the old “socially liberal, fiscally conservative” line that says poverty is about culture and effort and not about wages and benefits. So this spectrum has existed for a long time now in our politics. I think it’s easier in some ways for progressives to think about what we have the power to change, which again is the discourse that’s coming from the elite, very online, mostly white progressives. +
++But I don’t think this is the real issue. +
++Yeah, I don’t think it is either, it’s just particularly salient right now for lots of reasons. But it’s important to say that there’s a flip side to some of these arguments about how the left frames these issues. As you point out in the book, Obama went out of his way to deemphasize race and appeal to the best of us — and what did he get? He got a Tea Party that used the language of fiscal responsibility to organize white resentment and undermine his presidency, so there’s that. +
++I’m curious if you think Obama’s story speaks to the limits of progressive nationalism? +
++I think it speaks to the limits of colorblind triumphalism and to our ability to have a conversation about this country within this ecosystem. I think Barack Obama understands race and always has. But I think that the Democratic Party leadership, and the mostly white people around Obama’s campaign, were so close to somebody who gave the lie to all of it. In my experience from having conversations with people who were in Obama’s circle, they really didn’t realize the extent of racism in our politics and our policymaking. They just didn’t get it. +
++And they hadn’t done the work to understand just how central race and racism was, and what the tools looked like, and how they’re deployed. But they were also white and they actually had a gut-level caution around talking about race explicitly. I think there was the assumption that by not talking about it explicitly, they could avoid the mines. And that was wrong. +
++That I think was the big insight that we gleaned from the Race Class Narrative project. We realized that there’s a way, and really an imperative, to engage on racism that isn’t feeding into the reactionary right-wing message but, in fact, gives white people and people of color a way to see that we’re all in this country together. +
++That feels like a good place to pivot toward the solution, or the story you think we need to tell moving forward. What does that look like? +
++I think we have to tell a certain story and that story has to be heard through action. This is a point I feel I need to keep making. Because of the economics of democratic activism, there’s a lot of emphasis on getting the right message. It’s important, but it’s necessary, not sufficient. +
++We need to include in our worldview the story of the drained public pool. A way of understanding that this country had hit on the formula for creating middle-class security for working-class people — and walked away from it because of racism. And that the nostalgia of the Trump message to “Make America Great Again” contains some truth that the economic data really does bear out. Economic life really was better and easier in the past. But the people who destroyed that weren’t Black or brown people or women who wanted a seat at the table. It was the white elites who used racial and gender fears and distrust to convince the majority of white voters to turn their back on that formula. So I think that is really important. +
++We’re also in this resurgence of organizing and we have to double down. Ordinary people have experienced a rebirth of civic life. Whether they’re doing it for their own survival, or because they’re making minimum wage, or because their moral sense of self has been violated by America’s inequalities, people have decided that a part of being an American and a human being right now is to organize. And that is the space that has always changed lives and changed history. And we are in that space right now. And that’s what’s exciting and hopeful to me. It’s why I say in the book that there are solidarity dividends to be had, but only through cross-racial organizing. +
+More Americans than ever are willing to get vaccinated against the coronavirus, but a partisan divide remains. +
++The United States’ vaccination rate has been increasing — and as of Saturday morning, the Centers for Disease Control and Prevention (CDC) reported that 16.7 percent of US adults are fully vaccinated. +
++That’s still far from the 75 to 85 percent of Americans experts estimate need to be vaccinated in order to get the coronavirus pandemic under control, but recent research indicates that goal is within reach: a February survey by the Pew Research Center found 69 percent of American adults either have received at least one dose of vaccine — or intend to be vaccinated. +
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+That’s an improvement over recent months; in November, before vaccinations had been rolled out, about 60 percent of Americans said they planned to be vaccinated.
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+But there remains a deep partisan divide in willingness to be vaccinated — and in how Americans view the danger caused by the pandemic. Pew’s work, and other recent surveys, have found Democrats are more likely than Republicans to be willing to take the vaccine, and are more likely to be concerned about the public health ramifications of the pandemic.
+
+As Zeeshan Aleem recently wrote for Vox: +
++++CBS News released a poll conducted between March 10 and 13 which found 33 percent of Republicans say they won’t get the vaccine when it becomes available to them, while just 10 percent of Democrats said the same. In that survey, 47 percent of Republicans said they’ve already received the vaccine or plan to do so, compared to 71 percent of Democrats. +
++Those findings follow a recent poll from NPR/PBS NewsHour/Marist which found that 47 percent of people who supported former President Donald Trump in the 2020 election say they won’t choose to be vaccinated (versus 10 percent of Biden supporters), as well as a Monmouth University poll released earlier in March that found 59 percent of Republicans either wanted to wait and “see how it goes” before getting vaccinated, or said they were likely to never get one. By contrast, 23 percent of Democrats felt the same way. +
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+Similarly, Pew found 83 percent of Democrats have been vaccinated, or plan to be, compared to 56 percent of Republicans. +
+
+The Kaiser Family Foundation and Washington Post recently discovered that partisan vaccine hesitancy extends to the medical profession. A survey they conducted from February 11 to March 7 found 40 percent of Republican health care workers — including doctors, nurses, and staff — feel available vaccines may not be safe and effective. That view was held by 28 percent of Democrat health care workers.
+
+Why this is the case is not completely clear — Dr. Anthony Fauci, the top infectious disease expert in the United States, told Meet the Press that the divide “makes absolutely no sense.” +
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+One thing polls have made clear of late is that people’s political inclinations tend to correspond with how worried they are about the virus in general, something that could influence how likely they are to take measures to prevent exposure and infection. +
++According to the Pew survey, for instance, 82 percent of Democrats say that the coronavirus outbreak is a major threat to the health of the American population, compared to 41 percent of Republicans. That divide has been fairly steady since last March, when 33 percent of Republicans, and 59 percent of Democrats, were worried about the threat Covid-19 posed to public health. +
+ ++Pew also found Republicans to be much less concerned about the emergence of new variants of the coronavirus — 40 percent of Republicans said they worry these variants, some of which are more transmissible and deadly, could lead to “a major setback” in progressing toward the end of the pandemic, compared to 60 percent of Democrats. Members of both parties largely agree that the virus is a threat to the economy, however, with 83 percent of Democrats and 81 percent of Republicans sharing that sentiment. +
++A Franklin Templeton/Gallup study conducted in December 2020 — when confirmed daily cases regularly topped 200,000 (compared to the 50,000 to 60,000 confirmed cases seen for most of March 2021) — found Republicans far less likely to believe a coronavirus infection posed a hospitalization risk than Democrats. Members of both parties were found to vastly overestimate an infected person’s chances of being hospitalized, with 28 percent of Republicans, 41 percent of Democrats, and 35 percent of independents believing the hospitalization rate was at least 50 percent. Far more Republicans than Democrats — 26 percent to 10 percent — correctly responded that about 1 to 5 percent of those infected must be hospitalized. +
+ ++According to more recent polling from CBS/YouGov (conducted from March 10 to 13), 51 percent of Republicans said they weren’t concerned about being infected with Covid-19, compared to the 17 percent of Democrats who weren’t concerned. When asked why they weren’t concerned, most Republicans said the risk of infection was exaggerated or declining. +
++These numbers suggest that at least a portion of Republican vaccine hesitancy may stem from some Republicans feeling as if the coronavirus is not something that is overly dangerous — or something to fear. +
++The results come as a majority of Americans express optimism about the state of the pandemic. About 60 percent of Americans say that the “coronavirus situation” is getting better, and 26 percent said it’s staying the same, according to a Gallup poll taken February 14 to 21. Only 14 percent say it’s getting worse, the lowest response to that question since July. For the pandemic to end, however, more people than are currently willing to do so will need to take a vaccine — and key to making that happen will be overcoming hesitancy among all groups, Republican voters included. +
++The eruption near Reykjavik followed months of earthquakes, and led to beautiful orange and red skies. +
++After months of earthquakes, a long-dormant volcano in the southwest of Iceland erupted on Friday night, leading to dramatic videos and splendid red skies near the country’s capital city. +
++According to the Icelandic Meteorological Office, the eruption near Mount Fagradalsfjall, about 20 miles southwest of Reykjavik, took place at 8:45 pm. Though considered small, the eruption created a fissure about 1,640 feet long, and spewed more than 10 million square feet of lava, sometimes in fountains reaching heights of more than 300 feet. +
+++A new video of the eruption at Geldingardalur valley in Reykjanes peninsula. Taken from the Coast Guard helicopter. #Reykjanes #Eruption #Fagradalsfjall pic.twitter.com/B862heMzQL +
+— Icelandic Meteorological Office - IMO (@Vedurstofan) March 19, 2021 +
+It was the first volcanic eruption in this part of Iceland — the Reykjanes Peninsula, home to Reykjavik, where most of the country’s residents live — in 781 years. And it was the first time this particular volcano had gone off in about 6,000 years. +
++The eruption, in the Geldinga Valley, was remote enough that evacuations were not necessary, and no structures were endangered. +
++“As of now it is not considered a threat to surrounding towns,” said Iceland’s prime minister, Katrín Jakobsdóttir, on Twitter on Friday night. “We ask people to keep away from the immediate area and stay safe.” +
++++A volcanic eruption has begun in Fagradalsfjall on the Reykjanes peninsula. We are monitoring the situation closely and as of now it is not considered a threat to surrounding towns. We ask people to keep away from the immediate area and stay safe. https://t.co/iIACfCc31E +
+— Katrín Jakobsdóttir (@katrinjak) March 19, 2021 +
+Experts warned residents to beware emissions of dangerous gases, including carbon dioxide and sulfur dioxide, and there were some resulting traffic jams. Drones were temporarily prohibited from flying over the area, to allow scientists first access, but flights in and out of the international Keflavik Airport have not been affected. +
++The head of emergency management in the country told people to close their windows and stay inside to avoid volcanic gas pollution, which could spread as far as Thorlákshöfn, a city about 30 miles south of Reykjavik. +
++But on Saturday, the meteorological office said, “Currently, gas pollution is not expected to cause much discomfort for people except close up to the source of the eruption.” +
++The eruption is ongoing, and could last for “a day or a month,” Magnús Tumi Gudmundsson, a geophysicist at the University of Iceland, told RÚV, the Icelandic National Broadcasting Service. +
++++The small eruption poses no immediate danger and could last for a day or a month, according to Professor Magnús Tumi Guðmundsson #Reykjanes #volcano #eruption https://t.co/V8VDH07DTT pic.twitter.com/5Xc6wbPDJo +
+— RÚV (@RUVohf) March 20, 2021 +
+That makes this latest Icelandic geologic event starkly different than than the large-scale earthquake at the Eyjafjallajokull volcano in 2010, which caused more than 100,000 flights across Europe to be canceled for weeks afterwards as ash spread across northern Europe and Great Britain. That was described as the largest shutdown of airspace since WWII. +
++“The more we see, the smaller this eruption gets,” Páll Einarsson, a geophysicist at the University of Iceland, told the Associated Press on Saturday. +
++Despite the relatively small size, the eruption provided residents with unique views — and people across the region shared photos of the skies, as scientists set up a livestream of the flowing lava. +
++++This is Fagradalsfjall. It’s about 15 miles south of Reykjavik and just erupted. You can start practicing your pronunciation:
+— Ragnar Fjölnisson (@rfjolnisson) March 19, 2021 +
Foie-gras-thals-fiat-ill
Have fun#iceland #volcano pic.twitter.com/IYFHQMzWsx +
+Iceland is no stranger to volcanic activity. There is usually an eruption every four or five years because the island is in a region that is particularly susceptible to seismic activity. The most recent one, in 2014, was at Holuhraun, a lava field in the Icelandic Highlands. +
++Earthquakes are a familiar experience, too; since 2014, the country registered between 1,000 and 3,000 earthquakes per year. But since December 2019, that number has dramatically increased, according to the New York Times; scientists are still working to understand why. +
++In the last week alone, Iceland experienced more than 18,000 earthquakes, with more than 3,000 on Sunday. At least 400 had taken place in the area of the volcano the day before the eruption — and that was a relatively calm day, according to state meteorologists. +
++“This is somewhat less seismic activity in comparison to previous mornings where the numbers have been around 1,000 earthquakes,” the meteorological office said. +
++Many of those earthquakes were undetectable to ordinary people, but some were of magnitude 3 and greater, so that they could be felt. The largest was a 5.7-magnitude quake on the morning of February 24, followed by a magnitude 5 tremor 30 minutes later. +
++“I have experienced earthquakes before, but never so many in a row,” Reykjavik resident Audur Alfa Ólafsdóttir told CNN earlier this month. “It is very unusual to feel the Earth shake 24 hours a day for a whole week. It makes you feel very small and powerless against nature.” +
++According to Thorvaldur Thórdarson, a professor of volcanology at the University of Iceland, the cause of this dramatic increase in seismic activity is still being studied. +
++“We are battling with the ‘why’ at the moment. Why is this happening?” he told CNN. “It is very likely that we have an intrusion of magma into the [Earth’s] crust there. It has definitely moved closer to the surface, but we are trying to figure out if it’s moving even closer to it.” +
++Icelanders were warned about possible volcanic activity as a result of the earthquakes beginning on March 3. Officials at the time did not expect the event to be life-threatening or affect property. +
++Iceland’s location along a series of tectonic plates — known as the Mid-Atlantic Ridge — has made it uniquely susceptible to activity. +
++As the Times’s Elian Peltier writes, “The country straddles two tectonic plates, which are themselves divided by an undersea mountain chain that oozes molten hot rock, or magma. Quakes occur when the magma pushes through the plates.” +
++Officials, including Justice Minister Áslaug Arna Sigurbjörnsdóttir, the Coast Guard, and first responders shared overhead images of bright lava spilling through the fissure. +
++++Photo I took tonight over the volcanic eruption at Reykjanes Iceland. We are monitoring the situation closely and as of now it is not considered a threat to surrounding towns. #Iceland pic.twitter.com/6lTOG4xwjt +
+— Áslaug Arna Sigurbjörnsdóttir (@aslaugarna) March 20, 2021 +
+And many Icelanders shared images on social media of the eruption’s aftermath, which cast an orange hue into the sky. At night, from certain angles, its glow merged with the famed green and blue of the northern lights. +
++++‘Volcanic Eruption and Northern Lights, could it get more Icelandic?’
+— Zirr (@ItsAzirr) March 20, 2021 +
Piotr Slawomir Latkowski #Iceland #volcano pic.twitter.com/QweGQrLnJc +
+Pop star Björk — perhaps Iceland’s most famous resident — was one of those expressing excitement about the historic event and ensuing beauty. +
+ ++“YESSS !! , eruption !!” she wrote on Instagram on Friday. “We in iceland are sooo excited !!! we still got it !!! sense of relief when nature expresses herself !!!” +
+Ind vs Eng | Indian team arrives in Pune for ODI leg - The three ODI matches are to be played at the MCA stadium in Gahunje, on the outskirts of the city, on March 23, 26 and 28, sans spectators.
Ind vs Eng ODIs: England name squad for three-match ODI series, injured Archer dropped - Archer has been deemed unfit for selection for the ODI series that features matches on 23, 26 and 28 March, the ECB said
Football Delhi Women’s League to kick off from March 22 - The opening match of the Football Delhi Women’s League 2020-21 will be played on Monday between Eves Sports Club and Frontier FC Delhi at the Ambedkar
ISSF World Cup | India win silver in men’s team air rifle event - A total of 294 shooters from as many as 53 countries are participating in the tournament.
Man City into FA Cup semifinals, keeps quadruple dream alive - Guardiola’s players are sweeping all before them this season, having also reached the final of the English League Cup, the quarterfinals of the Champions League and forged a 14-point lead in the Premier League.
Lactating mothers, pregnant women chosen for poll duty - Some complain that exemption denied citing shortage of personnel
Coronavirus | 6 crore COVID-19 vaccine doses sent to 76 nations, 4.5 crore doses administered in India: Harsh Vardhan - The Health Minister called for making the vaccination drive a ‘Jan Aandolan’
Secunderabad-Shalimar special to be augmented with one AC coach - Train no. 02773/02774 Shalimar-Secunderabad-Shalimar Special will be augment with one extra AC-3 tier coach, on a permanent basis, with effect from Ap
West Bengal Assmebly elections | BJP runs on schemes, TMC runs on scams: Narendra Modi - Ms. Banerjee has been calling on party workers to keep an eye on EVM machines fearing tampering of the machines
Unease among sections of Congress workers of Narasimharaja constituency - The Karnataka Pradesh Congress Committee’s (KPCC) decision to suspend three supporters of former Minister Tanveer Sait from the party for their report
Covid: France and Poland increase lockdown measures as infections surge - Some 21 million people in France are affected, while in Poland shops and hotels are shut nationwide.
Iceland volcano: Lava-spewing Fagradalsfjall ‘subsiding’ - The eruption was the first in the area for about 800 years and followed thousands of earthquakes.
Covid restrictions: Can music festivals be safely planned? - A music festival takes place as an experiment in the Netherlands, despite the rest of the country being under lockdown.
Domestic violence: Turkey pulls out of Istanbul convention - Human rights groups say the move is a “huge setback” to efforts to combat domestic violence.
Rugby Union: France deny Wales at the death - France inflict heartbreak on Wales as they seal a 32-30 victory in dramatic fashion to deny Wayne Pivac’s side a Grand Slam in Paris.
New York lawmaker wants to ban police use of armed robots - Use of Boston Robotics’ Digidog intensifies concerns about police militarization. - link
Mouse embryos grow for days in culture, but the requirements are a bit nuts - And human embryos now get to the earliest state of development in a dish. - link
Facebook finally explains its mysterious new wrist wearable - Will we be able to trust it with a new form of personal data? (Probably not.) - link
Apple bent its rules for Russia—and other countries will take note - Russian iPhone buyers soon to see prompts to install software developed in Russia. - link
Hackers are exploiting a server vulnerability with a severity of 9.8 out of 10 - As if the mass-exploitation of Exchange servers wasn’t enough, now there’s BIG-IP. - link
+They/Them +
+ submitted by /u/Pandamancan_
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+“It’s to look at.” +
+ submitted by /u/honolulu_oahu_mod
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+That percentage is zero, that’s a good percentage of Nazi friends to have +
++Edit: Holy SHIT I did not expect this to blow up lmfao thank you for the awards! and fuck da haterz +
+ submitted by /u/Blutertle420
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+Madame: What can we do for you? +
++Tyrion: I need a woman to lay with, for mine has left me. +
++Madame: Whatever for? And what’s with the honeycomb and the mule? +
++Tyrion: My woman found a genie in a bottle, and he granted her three wishes. The first was for a house fit for a queen, so he gave her this damn honeycomb. The second wish was that she have the nicest ass in all the land, so he gave her this damn donkey… +
++Madame: And what about the third wish? +
++Tyrion: Well… she asked the genie to make my cock hang down past my knee. +
++Madame: Well that one’s not so bad eh? +
++Tyrion: Not so bad!? I used to be six foot three! +
+ submitted by /u/JaredLiwet
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+So they can Scandinavian. +
+ submitted by /u/CrashRocks1419_
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