diff --git a/archive-covid-19/27 January, 2021.html b/archive-covid-19/27 January, 2021.html new file mode 100644 index 0000000..48125da --- /dev/null +++ b/archive-covid-19/27 January, 2021.html @@ -0,0 +1,195 @@ + +
+ + + ++Introduction: Patients with Coronavirus Disease 2019 (COVID-19) frequently experience a hyperinflammatory syndrome, that leads to unfavorable outcomes. This condition resembles Secondary Hemophagocytic Lymphohistiocytosis (sHLH) described in neoplastic, rheumatic and other infectious diseases. However, it has not been prospectively studied on these patients. A scoring system (HScore) has been validated for sHLH, and recently proposed to evaluate hyperinflammation in COVID-19. Methods: 143 patients aged â„18 years admitted because of COVID-19 were enrolled in a prospective, single-center, cohort study. HScore was calculated within the 72 hours since admission. The incidence of sHLH during hospitalization was evaluated. Additionally, the relationship between HScore â„130 points and either the requirement of mechanical ventilation or 60-days mortality was explored. Results: The median age of enrolled patients was 57 (21-100), and 63.6% were male. The median HScore was 96 (33-169). One patient was diagnosed with sHLH (incidence 0,7%), due to a HScore of 169. After adjusting for age, sex, comorbidities and obesity, HScore â„130 was independently associated with the composite clinical outcome (HR 2.13, p=0.022). Conclusion: sHLH is not frequent among COVID-19 patients. HScore can efficiently predict the risk for poor outcomes. +
++Higher transmissibility of SARS-CoV-2 in cold and dry weather conditions has been hypothesized since the onset of the COVID-19 pandemic but the level of epidemiological evidence remains low. During the first wave of the pandemic for Spain, Italy, France, Portugal, Canada and USA presented an early spread, a heavy COVID-19 burden, and low initial public health response until lockdowns. We used regional death counts as a proxy for infections while diagnostic tests remained limited and calculated a basic reproduction number (R0) in 63 regions. After adjusting for population density, early spread of the epidemic, and aged population, temperature and humidity were negatively associated to SARS-CoV-2 transmissibility. A -1g/m3 lower mean absolute humidity was associated with a 0.15-unit higher R0. Below 10°C, a 1°C-higher temperature was associated with a 0.16-unit lower R0. Our results confirm a strong dependency of SARS-CoV-2 transmissibility to weather conditions in the absence of control measures. The initiation of the second wave in north-west hemisphere countries was likely triggered by the transition from summer- to winter-like conditions. High levels of restrictions to social activities should be maintained until spring to avoid or limit a third wave. +
+Dexamethasone for COVID-19 - Condition: Â Covid19
Intervention: Â Drug:Â Dexamethasone
Sponsor:  University of Oklahoma
Not yet recruiting
Phase III Study of AZD7442 for Treatment of COVID-19 in Outpatient Adults - Condition: Â COVID-19
Interventions: Â Drug:Â AZD7442; Â Drug:Â Placebo
Sponsor: Â AstraZeneca
Not yet recruiting
Fluvoxamine Administration in Moderate SARS-CoV-2 (COVID-19) Infected Patients - Condition: Â Covid19
Interventions: Â Drug:Â Placebo; Â Drug:Â Fluvoxamine
Sponsor:  SigmaDrugs Research Ltd.
Recruiting
The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial) - Condition: Â Covid19
Interventions:  Drug: Ivermectin 0.6mg/kg/day;  Drug: Ivermectin 1.0mg/kg/day;  Drug: Placebo;  Drug: Hydroxychloroquine
Sponsor:  Corpometria Institute
Not yet recruiting
APTâą T3X on the COVID-19 Contamination Rate - Condition: Â COVID-19
Interventions:  Drug: Tetracycline hydrochloride 3%;  Drug: Placebo
Sponsors:  University of Nove de Julho;  Santa Casa de Misericórdia de Porto Alegre
Not yet recruiting
A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia - Condition: Â COVID-19
Interventions:  Drug: ORTD-1 low dose;  Drug: ORTD-1 mid dose;  Drug: ORTD-1 high dose;  Other: Vehicle control
Sponsor:  Oryn Therapeutics, LLC
Recruiting
Efficacy of Nano-Ivermectin Impregnated Masks in Prevention of Covid-19 Among Healthy Contacts and Medical Staff - Condition: Â Covid-19
Intervention:  Other: ivermectin impregnated mask
Sponsor:  South Valley University
Recruiting
COVID-19 Immunologic Antiviral Therapy With Omalizumab - Condition: Â Covid19
Interventions: Â Biological:Â Omalizumab; Â Other:Â Placebo
Sponsor: Â McGill University Health Centre/Research Institute of the McGill University Health Centre
Not yet recruiting
IMUNORÂź Preparation in the Prevention of COVID-19 - Condition: Â Covid19
Intervention: Â Drug:Â IMUNOR
Sponsor:  University Hospital Ostrava
Not yet recruiting
Clinical Experimentation With Tenofovir Disoproxyl Fumarate and Emtricitabine for COVID-19 - Condition: Â Covid19
Interventions:  Drug: Vitamin C 500 MG Oral Tablet;  Drug: Tenofovir disoproxyl fumarate 300 MG Oral Tablet;  Drug: Tenofovir disoproxyl fumarate 300 MG plus emtricitabine 200 MG Oral Tablet
Sponsors:  Universidade Federal do Ceara;  Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico;  SĂŁo JosĂ©Â Hospital for Infectious Diseases - HSJ;  Central Laboratory of Public Health of CearĂĄ - Lacen-CE
Recruiting
Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19 - Condition: Â COVID-19
Interventions:  Drug: Doxycycline Tablets;  Drug: Rivaroxaban 15Mg Tab;  Combination Product: Hydroxychloroquine and Azithromycin
Sponsor:  Yaounde Central Hospital
Recruiting
Phase IIb Clinical Trial of Recombinant Novel Coronavirus Pneumonia (COVID-19) Vaccine (Sf9 Cells) - Condition: Â COVID-19
Interventions: Â Biological: Recombinant COVID-19 vaccine (Sf9 cells); Â Biological:Â Placebo
Sponsors:  Jiangsu Province Centers for Disease Control and Prevention;  West China Hospital
Not yet recruiting
Famotidine vs Placebo for the Treatment of Non-Hospitalized Adults With COVID-19 - Condition: Â Covid-19
Interventions: Â Drug:Â Famotidine; Â Drug:Â Placebo
Sponsors:  Northwell Health;  Cold Spring Harbor Laboratory
Recruiting
Antiseptic Mouth Rinses to Reduce Salivary Viral Load in COVID-19 Patients - Condition: Â Covid19
Interventions:  Drug: Betadine© bucal 100 mg/ml;  Drug: OximenŸ 3%;  Drug: Clorhexidine Dental PHB©;  Drug: Vitis Xtra Forte©;  Drug: Distilled Water
Sponsors:  FundaciĂłn para el Fomento de la InvestigaciĂłn Sanitaria y BiomĂ©dica de la Comunitat Valenciana;  Hospital Universitario FundaciĂłn JimĂ©nez DĂaz;  Hospital Universitario General de Villalba;  Hospital Universitario Infanta Elena;  Hospital Universitario Virgen de la Arrixaca;  Hospital ClĂnico Universitario de Valencia;  Dentaid SL
Completed
COVID-19 and Pregnancy: Placental and Immunological Impacts - Condition: Â Covid19
Intervention:  Other: Specimens specific for the study
Sponsor:  Hopital Foch
Recruiting
Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein - Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2. We describe a panel of human mAbs binding to diverse epitopes on the N-terminal domain (NTD) of S protein from SARS-CoV-2 convalescent donors and found a minority of these possessed neutralizing activity. Two mAbs (COV2-2676 and COV2-2489) inhibited infection of authentic SARS-CoV-2 and...
BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2 - SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted an unbiased CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. We found that the protein BRD2 is an essential node in the cellular response to SARS-CoV-2 infection. BRD2 is required for ACE2 transcription in human lung epithelial cells and cardiomyocytes, and BRD2 inhibitors currently evaluated in clinical trials...
Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in millions of deaths worldwide and massive societal and economic burden. Recently, a new variant of SARS-CoV-2, known as B.1.1.7, was first detected in the United Kingdom and is spreading in several other countries, heightening public health concern and raising questions as to the resulting effectiveness of vaccines and therapeutic interventions. We and others previously...
A PCR amplicon-based SARS-CoV-2 replicon for antiviral evaluation - The development of specific antiviral compounds to SARS-CoV-2 is an urgent task. One of the obstacles for the antiviral development is the requirement of biocontainment because infectious SARS-CoV-2 must be handled in a biosafety level-3 laboratory. Replicon, a non-infectious self-replicative viral RNA, could be a safe and effective tool for antiviral evaluation. Herein, we generated a PCR-based SARS-CoV-2 replicon. Eight fragments covering the entire SARS-CoV-2 genome except S, E, and M genes...
Molecular Docking of Azithromycin, Ritonavir, Lopinavir, Oseltamivir, Ivermectin and Heparin Interacting with Coronavirus Disease 2019 Main and Severe Acute Respiratory Syndrome Coronavirus-2 3C-Like Proteases - In the current pandemic situation raised due to COVID-19, drug reuse is emerging as the first line of treatment. The viral agent that causes this highly contagious disease and the acute respiratory syndrome coronavirus (SARS-CoV) share high nucleotide similarity. Therefore, it is structurally expected that many existing viral targets are similar to the first SARS-CoV, probably being inhibited by the same compounds. Here, we selected two viral proteins based on their vital role in the viral life...
Development of a Cell-Based Luciferase Complementation Assay for Identification of SARS-CoV-2 3CL(pro) Inhibitors - The 3C-like protease (3CL^(pro)) of SARS-CoV-2 is considered an excellent target for COVID-19 antiviral drug development because it is essential for viral replication and has a cleavage specificity distinct from human proteases. However, drug development for 3CL^(pro) has been hindered by a lack of cell-based reporter assays that can be performed in a BSL-2 setting. Current efforts to identify 3CL^(pro) inhibitors largely rely upon in vitro screening, which fails to account for cell permeability...
Protective Effects of Lactoferrin against SARS-CoV-2 Infection In Vitro - SARS-CoV-2 is a newly emerging virus that currently lacks curative treatments. Lactoferrin (LF) is a naturally occurring non-toxic glycoprotein with broad-spectrum antiviral, immunomodulatory and anti-inflammatory effects. In this study, we assessed the potential of LF in the prevention of SARS-CoV-2 infection in vitro. Antiviral immune response gene expression was analyzed by qRT-PCR in uninfected Caco-2 intestinal epithelial cells treated with LF. An infection assay for SARS-CoV-2 was...
Repositioning of histamine H(1) receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2 - The spread of the corona virus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been intensifying in the past year, posing a huge threat to global health. There is an urgent need for effective drugs and vaccines to fight the COVID-19, but their advent may not be quite fast. Drug repurposing is a feasible strategy in the current situation, which could greatly shorten drug development time and help to response quickly to the novel virus...
The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial - BACKGROUND: Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not readily achievable with currently approved doses. There is limited evidence to support its clinical use in COVID-19 patients. We conducted a Pilot, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a single dose of ivermectin reduce the transmission of SARS-CoV-2 when administered early after disease onset.
Pragmatic, open-label, single-center, randomized, phase II clinical trial to evaluate the efficacy and safety of methylprednisolone pulses and tacrolimus in patients with severe pneumonia secondary to COVID-19: The TACROVID trial protocol - INTRODUCTION: Some COVID-19 patients evolve to severe lung injury and systemic hyperinflammatory syndrome triggered by both the coronavirus infection and the subsequent host-immune response. Accordingly, the use of immunomodulatory agents has been suggested but still remains controversial. Our working hypothesis is that methylprednisolone pulses and tacrolimus may be an effective and safety drug combination for treating severe COVID-19 patients.
Polyphenols as promising biologically active substances for preventing SARS-CoV-2: A review with research evidence and underlying mechanisms - Currently, antiviral drugs and/or vaccines are not yet available to treat or prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, we narrated the available data, from credible publishers, regarding the possible role of polyphenols and natural extracts-containing polyphenols in the prevention of coronavirus disease 2019 (COVID-19), and their immune-boosting properties. It was revealed that polyphenols could be considered as promising biologically active substances...
Luteolin and abyssinone II as potential inhibitors of SARS-CoV-2: an in silico molecular modeling approach in battling the COVID-19 outbreak - CONCLUSIONS: Conclusively, the current study proposes that luteolin and abyssinone II might act as potential therapeutic candidates for SARS-CoV-2 infection. In vivo and in vitro experiments, however, should be taken under consideration to determine the efficiency and to demonstrate the mechanism of action.
Identifying anti-coronavirus peptides by incorporating different negative datasets and imbalanced learning strategies - As the current worldwide outbreaks of the SARS-CoV-2, it is urgently needed to develop effective therapeutic agents for inhibiting the pathogens or treating the related diseases. Antimicrobial peptides (AMP) with functional activity against coronavirus could be a considerable solution, yet there is no research for identifying anti-coronavirus (anti-CoV) peptides with the computational approach. In this study, we first investigated the physiochemical and compositional properties of the collected...
Temporal development and neutralising potential of antibodies against SARS-CoV-2 in hospitalised COVID-19 patients: An observational cohort study - Antibody responses are important in the control of viral respiratory infection in the human host. What is not clear for SARS-CoV-2 is how rapidly this response occurs, or when antibodies with protective capability evolve. Hence, defining the events of SARS-CoV-2 seroconversion and the time frame for the development of antibodies with protective potential may help to explain the different clinical presentations of COVID-19. Furthermore, accurate descriptions of seroconversion are needed to inform...
Targeting cyclooxygenase enzyme for the adjuvant COVID-19 therapy - Despite vigorous efforts, the COVID-19 pandemic continues to take a toll on the global health. The contemporary therapeutic regime focused on the viral spike proteins, viral 3CL protease enzyme, immunomodulation, inhibition of viral replication, and providing a symptomatic relief encouraged the repurposing of drugs to meet the urgency of treatment. Similarly, the representative drugs that proved beneficial to alleviate SARS-CoV-1, MERS-CoV, HIV, ZIKV, H1N1, and malarial infection in the past...
COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS - - link
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
Covid 19 - Chewing Gum - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
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Die Erfindung betrifft ein FahrzeuglĂŒftungssystem (1) zum BelĂŒften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link
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Mund-Nasen-Bedeckung (1), wobei die Mund-Nasen-Bedeckung (1) mindestens an einem Ohr eines TrÀgers magnetisch befestigbar ist.
Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link
Andrew Yangâs Ideas on Universal Basic Income Earned Him Fans. But Can He Win Votes? - His pitch in the mayoral race is for New York to become the âanti-povertyâ city. - link
Can the COVID-19 Vaccine Beat the Proliferation of New Virus Mutations? - Stopping transmission blocks the opportunity for viral mutation. Vaccination is the only means we have of standing in the virusâs way. - link
Navalnyâs Long-Running Battle with Putin Enters a New Phase - The jailed opposition leader is creating a model of guerrilla political warfare for the digital age. - link
Bidenâs Pandemic Plan Might Just Work - The coronavirus is devastating America, and getting worseâbut itâs not too late for a concerted effort to save countless lives. - link
A Bold Proposal to Ease Child Poverty Is the Essence of Bidenomics - By targeting Americans that have been hit hardest by the pandemic, and also addressing lasting inequities, the new Administration is approaching this moment as one of great potential as well as great peril. - link
+As a new year and a new administration begin, we explore life in transition, from the new utopias to parents bucking the âbaby bustâ to Congressâs newcomers. +
++If one can summon any optimism nearly a year into a grim and persistent pandemic, this is the moment to do it. +
++It is a new year, after all (good riddance, 2020!). Nearly 20 million Americans have rolled up their sleeves and received a dose of a Covid-19 vaccine. And no matter your political affiliation, a new administration and transformed Congress and Cabinet perennially serve as a kind of reset button for America, each unfamiliar face a reminder of how wide open the possibilities are. So we cross our fingers in unison and hope for the best. +
++It only made sense that the latest issue of The Highlight look at life in this tenuous transition. From the beautiful and remote communities â the new utopias â where corona-cationers flock to avoid restrictions (and high numbers of Covid-19 cases), to the would-be parents bucking the pandemic âbaby bustâ trend and getting pregnant anyway, to first-term lawmakersâ inauspicious introduction to Capitol Hill, we confront a world in flux. With so much change afoot, we turned to poets, too, for words of inspiration and provocation at a time when people need a little bit of both. And if that doesnât move you, perhaps a crystal to bring on positive thinking will. +
++7 poets â including Saeed Jones, Alex Dimitrov, and Patty Crane â meditate on the year weâve had, the one ahead, and our dark, persistent past. +
++By Vox Staff +
++The New York Democrat discusses the growing progressive movement in his party, and how the US Capitol riot is shaping his priorities. +
++By Li Zhou +
++Coming Thursday +
++For a certain jet-setting sect, wide-open spaces with views, few Covid-19 cases, and the freedom to go maskless are all the rage. But who pays the price? +
++By Sarah Khan +
++Coming Friday +
++As crystalsâ soothing popularity continues, one â carnelian â attracts those in search of self-improvement and positivity. Is it too good to be true? +
++By Jaya Saxena +
++Coming Monday +
++âMaybe itâs like a psychological trick to make yourself feel better, but I donât regret it.â +
++By Chris Chafin +
++7 poets â including Saeed Jones, Alex Dimitrov, and Patty Crane â meditate on the year weâve had, the one ahead, and our dark, persistent past. +
++Part of The âNewâ Issue of The Highlight, our home for ambitious stories that explain our world. +
++Good poetry can help us hold two opposing ideas in our minds at once. +
++For instance: A new year is a blank page, waiting for us to write on it. It is a chance to begin all over again. A new presidential administration offers us the same chance. After the year weâve had, we have to believe in the possibility of a fresh beginning. +
++But also, how can you turn the page on 2020, much less on four years of tumult under Donald Trump? How can you imagine that what was written wonât keep bleeding out into 2021? +
++Last yearâs police brutality protests turned into this yearâs off-duty cops rioting at the Capitol; last yearâs hopes for a quick vaccine to quell the pandemic turned into this yearâs 4,000 people dead in one day. And no matter what happens under a new administration, our losses will stay lost. There are no fresh starts, and there are no blank pages, and we have to believe that, too. +
++To try to pull apart this moment, we turned to poets from across the country and asked them to send us poems for a new year. The poets represent the country, including 2014 finalist for the National Book Critics Circle Award for poetry Saeed Jones; 2020 US youth poet laureate Meera Dasgupta; former inaugural poet Richard Blanco; and former Academy of American Poets chancellor Jane Hirshfield. +
++In their work, the ideas of a fresh beginning and lingering wounds live and mingle together. They jostle against each other until both feel clear and vital and inescapable. Each on its own, each at the same time. +
++In âPoem of Blood,â Mahogany L. Browne dares us to just try to forget the past â and reminds us of exactly who cleans away the messiness when white people start talking about a fresh clean start. âBut iâm an old broad now,â she writes, â& I got plenty of anger to lend / the days have bled from two weeks / âtil forever / & i got blood on my mind.â +
++But in Dasguptaâs âgroceries on the moon,â forgetfulness becomes a vacuum, a blank space in which to inscribe and re-inscribe our old mistakes, and the mistakes of our parents. âi do not remember a great white before,â she tells us. âi do not remember the beginning. i do not / remember floating or saturn saying i do.â +
++Perhaps most redemptive of all is Hirshfieldâs âCounting, New Yearâs Morning, What Powers Yet Remain To Me.â This poem does not take place in a world without pain: Here, âthe feet of the new sufferings followed the feet of the old,â and âStone did not become apple. War did not become peace.â And yet, Hirshfield counters, âJoy still stays joy. Sequins stay sequins. Words still bespangle, bewilder.â +
++Art exists to help us understand two impossible ideas at the same time. The world is unbearable, but we have to bear it, and that contradiction is why we have art. More specifically, that is why we have poetry, so that what we cannot express in prose can find meaning. So that what we cannot bear in life, we can find a way to bear in verse. +
++These poems for a new year are here to let words bespangle, bewilder. Even as we try for a fresh start and fail, joy still stays joy. +
++âConstance Grady +
++Saeed Jones +
+
+The color of a memory is the difference
between haunted and hunted. In Mississippi,
red white and blue donât mean âremember
this is America.â They mean âhistory is a gun
and every bullet in its chamber wants you
to forget.â They mean âwe tried our best
not to be America and failed and now we keep
forgetting to forget and, anyway, who did you
vote for? No need to ask us. You already know.â
They mean the white man in the White House
tweeted this morning that heâs being lynched.
Outside my hotel â no, Iâm not from around here â
on the street corner, there is a plaque that tells me
where I can find the body of the townâs first white
settler. But itâs almost sundown and Iâve been told
darkness in Mississippi is not a metaphor so I chase
the shadows back into the hotel. At the bar, I beg
the bartender to make me a stronger drink. He tries
and he fails. Iâm scared and Black and mostly sober
at the hotel bar and reading an essay about lynching
when some Ole Miss frat boys explode into the room,
cheering in a dead language, and my heart doesnât
even wait for me to get the check. My heart is already
gone. My heart is cowering in the hallway in front
of my hotel room because I have the key and I just
now got the check and I keep forgetting to forget
that the America I was born in will not be
the America in which I die.
+
+Saeed Jones is a poet and author of the Kirkus Prize-winning memoir How We Fight for Our Lives and the poetry collection Prelude to Bruise. (Copyright 2021 by Saeed Jones.) +
++Richard Blanco +
+
+Stop closing the shades, let the sun glow again
like a god who loves and wakes me to me
in the wake of its divine light traveling millions of miles
to ripple mauve and amber into my window, raise
my shut eyes open, done dreaming. Breathe.
Let my coffeeâs steamy soul rise and bless me
every day with its aroma before I take my first sip.
Name each day a miracle, linger again in its mystery
of possibilities. Breathe. Set the mime-hands of my watch
back two minutes every day, until time and me disavow
each otherâs obligations. Open the newspaper, but read
between the black and white lines for its lies. Breathe.
Stop walking my dog, let him dog-walk me unleashed
through his park. Let his nose compass me toward
the smells of all Iâve stopped taking in: the sweet, ancient dank of mud and mosses, the
incense of pine tree bark. Let his ears point me to listen again
to all Iâve become deaf to: the wind harping through
the strings of leaved branches, the opera of wrens
gossiping about the weatherâs secrets. Breathe. Donât deal
with the mail every day, let bills and notices pile up
like a house of cards until it collapses on the kitchen counter.
Take up cooking again, but add music to my recipes:
sway my hips as I beat eggs to conga beats, tap my feet
as I chop shallots to the staccato of piano keys, sing along
as I strum the sauces slow and tender to the croon of a folk guitar.
Bake all the desserts I deserve, dip my finger into the frosting first, bite into the crust, lick
the plate clean, feast on my life. Breathe. Indulge
myself more often alone in the living room
where Iâd forgotten to live. Take down my old photo albums
from the shelves, stare at all the dusty years of myself
in those eyes I had forgotten were mine and still love me. Breathe. Sit on the porch every
night, but stop asking the moon: Who am I? Accept the moon as simply
the moon, and me as simply me, just as bright
and wise, just as scared and delicate as I was
last year, and will be this year, and the next and
the next, perfectly imperfect in the nothing of
my everything, breathing as if each breath
is forever my first and my last.
+
+Richard Blanco is an engineer, writer, and award-winning poet. Heâs the author of the 2019 book How to Love a Country and the 2013 inaugural poet of the United States for the inauguration of President Barack Obama; he was the first Latino to hold the role. +
++Jane Hirshfield +
+
+The world asks, as it asks daily:
And what can you make, can you do, to change my deep-broken, fractured?
I count, this first day of another year, what remains.
I have a mountain, a kitchen, two hands.
Can admire with two eyes the mountain,
actual, recalcitrant, shifting its pebbles, sheltering foxes and beetles.
Can make black-eyed peas and collards.
Can make, from last yearâs late-ripening persimmons, a pudding.
Can climb a stepladder, change the bulb in a track light.
For four years, I woke each day first to the mountain,
then to the question.
The feet of the new sufferings followed the feet of the old,
and still they surprised.
I brought salt, brought oil, to the question. Brought sweet tea,
brought postcards and stamps. For four years, each day, something.
Stone did not become apple. War did not become peace.
Yet joy still stays joy. Sequins stay sequins. Words still bespangle, bewilder.
Today, I woke without answer.
The day answers, unpockets a thought from a friendâ
donât despair of this falling world, not yet didnât it give you the asking
+
+Jane Hirshfieldâs ninth book of poems is Ledger (Knopf, 2020). A former chancellor of the Academy of American Poets and the founder of #PoetsForScience, she was elected in 2019 to the American Academy of Arts & Sciences. +
++Meera Dasgupta +
+
+âThe emptiness of space is a blank slate, offering us the opportunity to start over, on an endless canvas that can support our continuous cycle of learnings and failings.â
âAneesh Abraham, Super Dense Crush Load: The Story of Man Redux
+
+I. +
+
+$2.00 - oxygen
$3.99 - H2O
$0.99 - space rocks
$15.00 - daylight
and so they bound towards the sun. my
to-do becomes an orbital body amongst
cosmic spaceships. the list lets loose like
an old flag on mars.
+
+
+we like to believe in alternate realities.
that behind every black hole is another boy joyriding
a shopping cart through aisle fifteen. a mother
pulling her son away from the shelves of produce.
how she bargains breath for their safe passage
through a jettison of asteroids. from the ground,
we wish upon them like shooting stars.
there is a strength in numbers. i want to climb orionâs
belt to see if there is a kingdom on the other side.
if there is a god managing the checkout line from behind a
curtain of satellites where thousands of heroes whisper
the show must go on.
i wonder if there is an icarus pulling a sort of gravity from the
moon as he falls. a single father against an empire.
born of a half-life and shipwrecks. he leaps off of the edge
of the universe into an ocean. here the heavens call to
him. find me. find us. find you. find you.
+
+
+i do not remember a great white before. i do not
remember mother banging the door straight off the
hinges for the neighborâs potpourri or when she put
her hands on her hips and swore to turn on the damn
lights. i do not remember the beginning. i do not
remember floating or saturn saying i do.
somewhere, man bought the moon
and got a supermarket on a pockmarked
plain. a tower of vegetables for a sale price
of 1.99. and an automated speaker system
screeching melodies into a vacuum.
here, silence becomes a microphone
in the dark. the fridges gleam like the
cold comets of space blinking back at each
other in the moments between celestial
explosions.
they become an eye at the center of the
universe. here, we can bargain with the
sky.
+
+Meera Dasgupta is the 2020 United States youth poet laureate. Born in Queens, she is a senior at Stuyvesant High School, 2020 United Nations Global Goals ambassador, Climate Speaks winner, and more. +
++Mahogany L. Browne +
+
+The first to go are your breasts
Hanging like sandbags
Sad & remembering who they used to be
The way a wind chime whistle
can sound like a refrain: stay home, daughter
+
+No one wants to talk
About a womanâs body during a disaster
Like sheâs the disaster
Walking & moving slow toward the sun
+
+They rather talk about the things they canât want
to change until itâs voting season, or tax season or killing season
+
+Extra Extra!
Another black girl is forgotten âtil dust
The poets only remember her boyfriendâs name
Or her brotherâs shoe size
they only remember the black girl body
after she is gone
+
+The pastor reads from Genesis
we nod
pay tithes
pass the plate
& erase her initials from
the scoreboard
+
+Even the black feminist forgets she was once a girl child
She closes her eyes & calls her son Prophet
+
+Tells Prophet to never trust women
Then twists his dreads w/homemade beeswax
Her fingers cracked like stomped earth
Her scalp tingling w/bad news
& the news say
a disaster is coming
call it Irma, Katrina, Rona
+
+America got
a penchant for babyâs breath & blood milk
But the blocks still hot in Brooklyn
& the nannies still push strollers full of babies they ainât birth
Cause the Governor warns stay home
But the landlord echoes rent due
+
+Go head America
wreak havoc on the plantation
& charge the sharecropper to remove the sewage
+
+Stay safe
Stay home?
+
+Or
watch the next internet sensation
rely on old hip-hop t-shirts
& yoga pants while
Lizzo teaches her how to be human
+
+Yo
even the trees look at black bodies like
Welcome back
& the baby in the stroller ainât heard this lullaby
since they dreamt Similac
brown organic raw sugar go for double the price
@ whole foods
get in line
6 feet, fam
donât sleep, fam
+
+paychecks from the government
courtesy of the taxes already paid three times the amount
since the last two runs around this weak ass moon
+
+Gil Scott Heron was right
Here we all smack slapped
against the light of a smudged badge #
Glint my eyes
Flint in my sky
everybody wants my census report
but donât nobody want to give me healthcare
the water got blood in it
the trees got a memory
my city ainât on fire
but the fog is heavy
each building swaddled in grey shit
that make us sick
cover your mouth
cover your nose
stay inside
stay home
or be run over
& up on by the white woman who walks her dogs
so close you can hear what sheâs thinking
6 feet who?
the neighbors donât see me
but the broken man on the corner do
my breasts, old with age
they sag like my spirit
he timberland boot & black mask bark
he play brave
stomp his feet
& take up more sidewalk
then there is concrete
he howls at the sky
like it aint 12pm
like we ainât in a crisis
his eyes dart from my chest to my cheeks
but iâm an old broad now
& I got plenty of anger to lend
the days have bled from two weeks
âtil forever
& i got blood on my mind
i dare him one time
kiss my teeth loud
then dare him w/the clearing my throat
it sounds like a funeral
it distracts him from the sound of key rings
turning into knuckle rings
but he knows the different between frail & feral
he replaces his mask
corks his speech
& lets me pass
an unhinged door on tilt
âO can you hear the wind sing?
so close to death, so close to life,
little water, little daughter,
come home
+
+Mahogany L. Browne is a writer, organizer, educator, and the executive director of Bowery Poetry Club and poetry coordinator at St. Francis College. She is the author of several books, including the new novel Chlorine Sky (Crown Books for Young Readers), published in January. (Copyright 2021 by Mahogany L. Browne.) +
++Alex Dimitrov +
++The light before noon and what it does to the mind. +
+
+How you leaned against doors at parties, cried in bodegas,
read bathroom graffiti and did not ask for help.
+
+Some nights Second Avenue seemed to go on forever.
Some nights above a bar there was a plane that felt right.
+
+When you stood in parking lots, under the moon
you went silent.
+
+You thought about chance. History.
How cruel it is to be anyone.
+
+âYou know,â a friend told you,
âwe can talk about the past
+
+but itâs another country
without one way to get there.â
+
+Maybe thatâs easy.
Youâve seen what fog does to bridges.
+
+Maybe you forgot you could do anything before death. +
++Alex Dimitrov is the author of three books of poems, including Love & Other Poems (Copper Canyon Press), which will be published in February. He lives in New York. +
++Patty Crane +
+
+Glinting shards of dropped branch-ice
litter the white ground under the maples,
+
+each glassy fragment containing
its unique memory of tree,
that, as the day warms, thins and spreads
+
+into a gleaming tangle of light,
a crazed mirror held up to the future.
+
+Hope isnât anyoneâs to give.
It has to be found.
And I come out here to find it,
+
+to take each moment as it comes.
A kind of borrowing.
+
+A lone mourning dove arrives
in the smoky-blue sky of its feathers,
and lands, slender as a cupped hand,
+
+among the seeds scattered on the stone walkway,
its faint tracks in the snow-dustâbriefly mine.
+
+Patty Crane is the author of Bell I Wake To (Zone 3 Press, 2019), something flown (Concrete Wolf, 2018), and Bright Scythe (Sarabande Books, 2015), her translation of poems by Swedish Nobel laureate Tomas Tranströmer. +
++
+The New York Democrat discusses the growing progressive movement in his party, and how the US Capitol riot is shaping his priorities. +
++
++Part of The âNewâ Issue of The Highlight, our home for ambitious stories that explain our world. +
++Rep. Mondaire Jones (D-NY) was among those on the House floor when rioters stormed the Capitol on January 6. The newly elected Congress member was listening to remarks during the certification of the presidential election results â typically a routine, even somewhat dull proceeding in the transfer of power â when security abruptly announced the building had been breached by a mob. Jones, along with dozens of other new Democratic and Republican members, had been sworn in just three days earlier. +
++âMy life literally flashed before my eyes, and I know thatâs true for many of the approximately 200 other members of Congress who were [there] at the time,â Jones told Vox. +
++Jones has had a disquieting first few weeks. By their 10th day on the job, he and other new members â including Reps. Cori Bush (D-MO), Jamaal Bowman (D-NY), and Marie Newman (D-IL) â had endured the Capitol attack, helped finally certify election results after two months of baseless objections, and impeached the president for an unprecedented second time. +
++Itâs been a âjarringâ beginning, Jones, 33, told Vox, emphasizing that the riot â and the role some of his colleagues played in inciting it â has only strengthened his resolve to enact serious progressive reforms that âwill ensure that members of Congress are sane and responsive to the American people.â +
++Jones, who is one of the first openly gay Black men elected to Congress, is part of a new wave of progressives elected to the House, signaling just how energized the left-leaning wing of the Democratic Party continues to be. Since the election of âthe Squadâ in 2018, when members including Reps. Alexandria Ocasio-Cortez (D-NY) and Ayanna Pressley (D-MA) upset longtime incumbents â in part by running on policies to the left of more centrist Democrats â this young, diverse group of new lawmakers are bolstering their numbers on the Hill. Jones, campaigning on a progressive platform that won the endorsement of Ocasio-Cortez and Sens. Elizabeth Warren and Bernie Sanders, beat out competitor Adam Schleifer, a pharmaceutical heir, who outspent his campaign five to one. +
++As their ranks continue to grow, âprogressives in Congress are more powerful than they have ever been,â Jones says. A former staffer at the Justice Department during the Obama administration, Jones previously told NBC News that his trajectory has come as a surprise â and that he never thought heâd get elected to Congress âgrowing up poor, Black and gay,â in the district he now represents. +
++Jones, who was elected by his peers to represent the first-term members in Democratic leadership, will also be a key advocate for the new lawmakers, and a spokesperson for their concerns in weekly meetings. As their envoy, Jones makes sure Speaker Nancy Pelosi and others are aware of where the class stands on different subjects, including impeachment. +
++Jones spoke with Vox about what it means to be a Capitol Hill newcomer in a strange time, and why heâs so focused on democracy reforms. +
++This interview has been edited and condensed. +
++What has it been like to join Congress and have to process the attack on the Capitol, as well as the impeachment of President Trump, within the first two weeks of being in office? +
++Itâs been a jarring experience. I had expected to be giving my first floor speech in connection with the For the People Act, or the Covid-19 relief bill that Joe Biden has unveiled. But instead, my first speech was in connection with the second impeachment of Donald J. Trump, after having nearly died the week before, at the hands of not just the president of the United States but his Republican co-conspirators in the House, who helped to incite last weekâs violent insurrection. +
++Could you talk about your experience the day of the Capitol attack and what was going through your mind that day? +
++I was on the House floor with the Democratic leadership team, listening to debate during what historically has been a routine proceeding: certification of the November presidential election. +
++There was an abrupt announcement by security personnel that Capitol security had been reached by the mob outside, and that we would need to lock the doors to the House chamber from the inside. Minutes later, there was a very loud banging sound at one of the doors behind me from a mob of domestic terrorists. We were told to look under our seats and to pull out gas masks in case tear gas needed to be used. We were also told to prepare to lie down on the ground in the event of gunfire. +
++How has this experience shaped your view of Congress â and how does that compare to expectations you had? +
++It makes me even more committed to enacting critical democracy reforms, including those contained in the For the People Act, which would help elect better people to Congress. If you pass automatic voter registration to enfranchise an additional 50 million people nationally, you will get more Democrats elected to the United States Senate who will actually legislate in the best interest of the American people, rather than question the need for $2,000 survival checks, as [outgoing Georgia Republican senator] Kelly Loeffler did, because she has no commitment to helping everyday folks. +
++What does accountability look like to you for the attack on the Capitol? +
++I am laser-focused on holding Trumpâs co-conspirators in Congress accountable both through expulsion and criminal prosecution and public shaming. Because these people need to know that they can never do what they did last week again. +
++Could you talk about the new perspective and ideas youâre most excited to bring to Congress? +
++We need more people in office for whom policy is personal â whose lives are affected by the policies we are enacting in Washington. Iâm Black, openly gay, and was raised by a single mother who relied on Section 8 housing and food stamps just to get by. Thatâs exactly the perspective Iâve already been bringing to our policymaking discussions. +
++For too long, our political system has been designed to serve the wealthy and well-connected, but we have a real opportunity under unified Democratic control to change that and fight for a bold agenda that will improve the lives of working Americans throughout this country. +
++This work clearly has to start by fixing the root of our problems: our broken democracy. The insurrection we saw on January 6 started with the myth of voter fraud, which the GOP is using to lay the foundation for another decade of suppressing the votes of people of color, working people, and young people. +
++We must pass the For the People Act (or HR 1) to fight back against the ongoing assault on our democracy; that means ending partisan gerrymandering, establishing small-dollar public financing for congressional campaigns, and automatic voter registration. We must also expand the Supreme Court, whose 6-3 hyperpartisan, conservative majority poses an existential threat to democracy itself. +
++What is the top policy proposal that you plan to focus on as Congress continues to get underway? +
++COVID-19 relief is the No. 1 priority. And No. 2 has to be democracy reforms. Democracy reforms will ensure that members of Congress are sane and responsive to the American people. And that we get better policies, ones that actually help working people in this country rather than the superrich. +
++When it comes to Covid-19 relief, could you talk a bit about the provisions that you see as most important for the next bill to include? +
++Definitely $2,000 survival checks and direct aid to states and local governments. You know, I have been supportive of monthly $2,000 checks for every adult, and monthly $1,000 checks for every child since early last spring. +
++As someone who has been elected to represent the freshman class and be part of Democratic leadership, could you talk a little bit about what that role entails? +
++Well, I meet every week with the House Democratic leadership team, and I confirm the needs and concerns and desires of the freshman class, which is a diverse freshman class, both ideologically and in terms of life experience. It gives me an opportunity to advocate for things like the impeachment of this president, when that was still being considered. +
++I was able to say Iâve spoken to every single member of the freshman class, and theyâre all supportive of impeachment. It also allows me to advocate for the freshmen by pushing for them to have opportunities to lead and to legislate, so that they can show their districts that they are getting things done. +
++Given the ideological diversity that you mentioned, within both the freshman class and the Democratic caucus overall, how do you plan to keep on advancing progressive ideas? +
++Progressive policies are broadly popular with the American people. And in many instances, representatives in Congress have not caught up with public opinion. Progressives in Congress are more powerful than they have ever been. Our ranks have grown. And so has popular support for programs like Medicare-for-all and student debt cancellation. So I plan to work with other progressives on leveraging our votes to improve legislation. +
++Li Zhou is a politics and policy reporter for Vox. +
++
+Arsenal signs midfielder Odegaard on loan from Real Madrid - Odegaard has been at Madrid since 2015 â when he joined at the age of 16
Two Russian tennis players banned for life for match-fixing - The case focused on âmultiple incidents,â the ITIA said, including two matches they played together as doubles partners.
ICC ODI rankings | Virat Kohli, Rohit Sharma retain top two spots for batsmen - Jasprit Bumrah remained at the third spot in the bowler's list
Washington Sundar: âToo many expectations only add to the pressure. I donât want thatâ - Indian cricketer Washington Sundar seems composed despite accolades pouring his way following his Australia heroics, because he knows the road ahead is tough
Sourav Ganguly hospitalised again with discomfort in chest, parameters stable - The 48-year-old had undergone an angioplasty earlier this month after he was diagnosed with three blocked coronary arteries.
Never said doors for dialogue with farmers shut: Prakash Javadekar - The Union Minister said whatever decisions with regard to talks with farmers are taken, will be disclosed at the right time.
Sivasankarâs bail plea to be heard on Feb. 1 - In foreign currency smuggling case
Kerala HC issues notice to Virat Kohli, Tamanna on plea seeking ban on online gambling in Kerala - The celebrities are the brand ambassadors of online rummy games.
Farmersâ protests | Two unions withdraw from agitation citing Republic Day violence - Deeply pained by whatever happened during the tractor parade, says president of Bharatiya Kisan Union
Technical glitches halt supply of food kits - Second phase of distribution of free food kits had begun on January 23
Coronavirus: France's Sanofi to boost Pfizer vaccine supply amid EU shortages - Sanofi will produce doses of Pfizer/BioNTech which, along with AstraZeneca, has had supply problems.
Madrid feminist mural: Councillors thwart effort to remove artwork - City councillors step in to protect the artwork, which critics argued had a "political message".
Covid: Curfew stays despite 'scum' riots in Dutch cities - Three nights of rioting will not halt night curfews aimed at stopping coronavirus, say Dutch ministers.
Biden raises election meddling with Putin in first phone call - The Russian leader says his first call with the new US president was "business-like and frank".
Spanish Armada maps 'saved for the nation' - The maps depict the famous sea battle in which the English fleet was victorious in 1588.
Basic pandemic safety limits spread in schools - Infections spread in a school system were far lower than in its surrounding towns. - link
Warrior princess fights to save humanity in Raya and the Last Dragon trailer - "I wish to join this fellowship of butt-kickery." - link
Plex adds game-streaming as paid add-on, completely botches the landing - $4.99/mo service needs to straighten many issues before meriting the cost. - link
Sony adds HDMI to last yearâs Android phone, charges $2,500 - It's not a foldable. It's not plated in gold. It just has an HDMI port. - link
SpaceX adds laser links to Starlink satellites to serve Earthâs polar areas - Laser links connect Starlink satellites, reducing need for ground stations. - link
+A young man came from the parking lot and tried to cut in at the front of the line, but an old lady beat him back into the parking lot with her cane. +
++He returned and tried to cut in again but an old man punched him in the gut, then kicked him to the ground and rolled him away. +
++As he approached the line for the third time he said, "Look, if you don't let me unlock the damn door you're never going to get in there!â +
+ submitted by /u/ClutchingMyTinkle
[link] [comments]
+But there's a catch: The host said they have to get dressed up as 'emotions.' +
++So the first guy goes home and sticks his dick in a pear. +
++The second guy goes home and sticks his dick in a big bowl of custard. +
++They show up at the party together and knock on the door. The host opens up the door and his mouth falls agape as he sees the two. "What the hell are you doing? What are these costumes!?" +
++The first guy looks at the host and says, "Yo, I'm deep in dis pair." +
++The second guy says, "I'm fuckin' dis custid." +
+ submitted by /u/mikeydel307
[link] [comments]
+Please upvote because I want this house to be spotless +
+ submitted by /u/OskarW04
[link] [comments]
+The Polar Bear +
+ submitted by /u/PhummyLW
[link] [comments]
+A man goes to the Post Office to apply for a job. +
++The interviewer asks him, "Are you allergic to anything?" +
++He replies, "Yes, caffeine. I can't drink coffee." +
++"OK, have you ever been in the military service?" +
++"Yes," he says, "I was in Afghanistan for one tour." +
++The interviewer says, "That will give you 5 extra points toward employment." +
++Then he asks, "Are you disabled in any way?" +
++The guy says, "Yes. A bomb exploded near me and I lost both my testicles. +
++The interviewer grimaces and then says, "Okay. You've got enough points for me to hire you right now." +
++"Our normal hours are from 8 am to 4 pm. You can start tomorrow at 10 am and plan on starting at 10 am every day." +
++The guy is puzzled and asks, "If the work hours are from 8 am to 4 pm, why don't you want me here until 10 am?" +
++"This is a government job," the interviewer says. "For the first two hours, we just stand around drinking coffee and scratching our balls. So no point in your coming in for that." +
+ submitted by /u/Cherbotsky
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