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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Strategies of University Students to Cope with COVID-19 and the Role of Psychological Flexibility</strong> -
<div>
The COVID-19 outbreak is an important stress factor that threatens the health of individuals both physically and psychologically. Within the scope of struggling the outbreak, many precautions, such as quarantine practices, social distance rules, distance education, flexible working hours have been taken and the lives of individuals have changed greatly. One of the groups that have been significantly influenced by this process is university students. The primary purpose of this study is to determine the ways in which university students cope with the outbreak and to understand the role of psychological flexibility. There were 457 university students in the study. Participants completed an online questionnaire form comprising items relevant to their coping strategies and psychological flexibility levels. Results revealed that participants used transcendental coping the most while relational coping the least. Additionally, psychological inflexibility negatively predicted transcendental, behavioral, and relational coping behaviors. These results revealed the fact that psychological flexibility is an important mechanism that channels students’ coping behaviors in such a critical process.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/9ruqw/" target="_blank">Strategies of University Students to Cope with COVID-19 and the Role of Psychological Flexibility</a>
</div></li>
<li><strong>Disentangling dynamic affect trajectories for distinct depression courses during the COVID-19 pandemic</strong> -
<div>
Background. Why does adversity lead to mental health complaints in some, but not others? Individual differences in the development of depressive complaints are related to the regulation of affect states. The COVID-19 pandemic has caused a prolonged period of perturbations to the daily lives of people across the globe, providing an unparalleled opportunity to investigate how fluctuations in positive and negative affect relate to the evolution of mood complaints. Methods. 228 participants from the Boston College daily sleep and well-being survey completed at least 20 assessments of positive and negative affect and depression complaints between March 20th 2020 and June 26th 2020. We explored affect trajectories throughout this period and estimated longitudinal multilevel network models. Furthermore, we investigated how individual network structures relate to changes in depression severity over time. Results. On average, positive affect was reported somewhat higher than negative affect. However, when separating affect trajectories based on the individuals’ depressive complaints, we identified that individuals consistently experiencing depressive complaints report higher levels of negative affect compared with positive affect. Contrary, individuals consistently reporting no depressive complaints show opposite results. Furthermore, we found many and strong associations in the multilevel network between the distinct affect states and depressive complaints. Lastly, we established that the higher the connectivity of an individual’s network, the larger their change in depressive complaints is. Conclusions. We conclude that affect fluctuations are directly related to the development of depressive complaints, both within- and across individuals, and both within a single measurement moment and over time.
</div>
<div class="article-link article-html- link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/hv4cb/" target="_blank">Disentangling dynamic affect trajectories for distinct depression courses during the COVID-19 pandemic</a>
</div></li>
<li><strong>Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
SARS-CoV-2 inactivated vaccines have shown remarkable efficacy in clinical trials, especially in reducing severe illness and casualty. However, the waning of humoral immunity over time has raised concern over the durability of immune memory following vaccination. Thus, we conducted a non-randomized trial among the healthcare professionals (HCWs) to investigate the long-term sustainability of SARS-CoV-2-specific B cells and T cells stimulated by inactivated vaccines and the potential need for a third booster dose. Although neutralizing antibodies elicited by the standard two- dose vaccination schedule dropped from a peak of 29.3 AU/ml to 8.8 AU/ml 5 months after the second vaccination, spike- specific memory B and T cells were still detectable, forming the basis for a quick recall response. As expected, the faded humoral immune response was vigorously elevated to 63.6 AU/ml by 7.2 folds 1 week after the third dose along with abundant spike-specific circulating follicular helper T cells in parallel. Meanwhile, spike-specific CD4+ and CD8+ T cells were also robustly elevated by 5.9 and 2.7 folds respectively. Robust expansion of memory pools by the third dose potentiated greater durability of protective immune responses. Another key finding in this trial was that HCWs with low serological response to 2 doses were not truly non-responders but fully equipped with immune memory that could be quickly recalled by a third dose even 5 months after the second vaccination. Collectively, these data provide insights into the generation of long-term immunological memory by the inactivated vaccine, which could be rapidly recalled and further boosted by a third dose.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.09.12.21263373v2" target="_blank">Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine</a>
</div></li>
<li><strong>Relating psychiatric symptoms and self-regulation during the COVID-19 crisis</strong> -
<div>
Disruptions of self-regulation are a hallmark of numerous psychiatric disorders. Here, we examine the relationship between transdiagnostic dimensions of psychopathology and changes in self-regulation in the early phase of the COVID-19 pandemic. We used data-driven approach on a large number of cognitive tasks and self-reported surveys in training datasets. Then we derived measures of self-regulation and psychiatric functioning in an independent population sample (N = 102) tested both before and after the onset of the COVID-19 pandemic, when the restrictions in place represented a threat to mental health and forced people to flexibly adjust to modifications of daily routines. We found independent relationships between transdiagnostic dimensions of psychopathology and longitudinal alterations in specific domains of self-regulation defined using the drift diffusion model. Compared to the period preceding the onset of the pandemic, a symptom dimension related to anxiety and depression was characterized by a more cautious behavior, indexed by the need to accumulate more evidence before making a decision. Instead, social-withdrawal related to faster non-decision processes. Self-reported measures of self-regulation predicted variance in psychiatric symptoms both concurrently and prospectively, revealing the psychological dimensions relevant for separate transdiagnostic dimensions of psychiatry, but tasks did not. Taken together, our study shows that self-regulation can be affected depending on the interaction between external events and trait-like vulnerabilities and suggests that the study of cognition needs to take into account the dynamic nature of real-world events as well as within-subject variability over time.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/af892/" target="_blank">Relating psychiatric symptoms and self-regulation during the COVID-19 crisis</a>
</div></li>
<li><strong>Potential COVID-19 Immunomodulators and Beyond: NSAIDs Might Inhibit SARS CoV-2 ORF Proteins Induced Caspase Activation, Necroptosis and Endoplasmic Reticulum Stress.</strong> -
<div>
Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 We have previously suggested numerous immunomodulatory and anti-inflammatory benefits when NSAIDs are administered as first choice therapy early in management of COVID-19 and in this manuscript we add several additional clues and it is really unfortunate that for more than one year of relentless struggle, this call is not yet adopted to save precious lives that are succumbed every day.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/w52ms/" target="_blank">Potential COVID-19 Immunomodulators and Beyond: NSAIDs Might Inhibit SARS CoV-2 ORF Proteins Induced Caspase Activation, Necroptosis and Endoplasmic Reticulum Stress.</a>
</div></li>
<li><strong>NSAIDs/Nitazoxanide/Azithromycin Immunomodulatory COVID Protocol Might Inhibit SARS CoV-2 Replication Through Disruption of NF-κB Signaling</strong> -
<div>
Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 In March 2020, I’ve sent a correspondence to NEJM (20-06753) calling the claims that led the world to avoid non-steroidal anti- inflammatory drugs in COVID-19 management as a scam and it was rejected by this journal as well as more than a dozen of other journals until published almost six months later at the reputable InflammoPharmacology. In April 2020, a concept paper was rapidly published as a letter to the editor favoring nitazoxanide over ivermectin for management of COVID-19 together with azithromycin. Since then, a protocol has evolved to safely manage dozens of pediatric, geriatric, adult and pregnant COVID-19 patients and it was rejected by dozens of journals since May 2020 (20-19376) and eventually it was published in August 2021 only after publishing several papers to justify its academic basis in highly reputable journals. I repeat my long-ignored claim NSAIDs/Nitazoxanide/Azithromycin immunomodulatory protocol (Kelleni’s Protocol) a game-changer that might end this pandemic safely and immediately and, in this manuscript, I’m adding more recent evidence that justify my claim.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/g2h74/" target="_blank">NSAIDs/Nitazoxanide/Azithromycin Immunomodulatory COVID Protocol Might Inhibit SARS CoV-2 Replication Through Disruption of NF-κB Signaling</a>
</div></li>
<li><strong>NSAIDs, SARS CoV-2 ORF Proteins, Caspases, and CARD14: Solving the Mystery of COVID-19 and Beyond</strong> -
<div>
Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 In this manuscript we further build on our previous suggested potential beneficial effects of using NSAIDs as first choice drugs in COVID-19 management while discussing the role that SARS CoV-2 ORF proteins induced caspases play in the pathophysiology of SARS CoV-2 infection. Moreover, we postulate that CARD 14, a caspase recruitment domain-containing protein of the membrane-associated guanylate kinases family, mutations might share a role in development of severe and critical COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/8ha9u/" target="_blank">NSAIDs, SARS CoV-2 ORF Proteins, Caspases, and CARD14: Solving the Mystery of COVID-19 and Beyond</a>
</div></li>
<li><strong>Measuring the effects of misinformation exposure on behavioural intentions</strong> -
<div>
Misinformation has been a pressing issue since the beginning of COVID-19 pandemic, threatening our ability to effectively act on the crisis. More recently, the availability of vaccines in developed countries has not always translated into high vaccination rates, with online misinformation often presented as the culprit. Yet little is known about the actual effects of fake news on behavioural intentions. Does exposure to misinformation about COVID-19 vaccines indeed affects people’s intentions to receive such a vaccine? This paper attempts to answer this question through three preregistered experiments (N=3463). In Study 1, participants (n=1269) were exposed to fabricated pro- or anti- vaccine information or to neutral true information, and then asked about their intentions to get vaccinated, alongside a few other behavioural intentions. In Study 2, participants (n=1863) were exposed to true pro- and anti-vaccine information, while Study 3 (n=1548) compared the effects of single and multiple exposures to novel misinformation about COVID-19 vaccines. The results showed that exposure to false information on the vaccines did not affect the participants’ intentions to get vaccinated, even when multiple exposures led them to believe that the headlines were more accurate than in the single exposure conditions. An exploratory meta-analysis of studies 1 and 3 (n=2683) showed that exposure to false information about COVID-19 vaccines, regardless of whether it was in favour of or against vaccines, increased vaccination intentions. We conclude by cautioning researchers against equating exposure to misinformation or perceived accuracy of false news with actual behaviours.
</div>
<div class="article-link article-html- link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/2xngy/" target="_blank">Measuring the effects of misinformation exposure on behavioural intentions</a>
</div></li>
<li><strong>The potential crucial role of COX-1 inhibition and/or Aspirin triggered lipoxins and resolvins in amelioration of COVID-19 mortality</strong> -
<div>
Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 Aspirin has been recently suggested to be independently associated with reduced risk of mechanical ventilation, ICU admission and in-hospital mortality of COVID-19. However, we claim that the molecular interpretation of these important results was not scientifically valid and we provide our academic interpretation that is also basing on our real-life practice using non-steroidal anti-inflammatory drugs in management of COVID-19 and we suggest that inhibition of COX-1 and/or COX-2 enzymes might play a life saving role in COVID-19 management and we further discuss the potential of aspirin triggered lipoxins and resolivns in the same context.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/2rf98/" target="_blank">The potential crucial role of COX-1 inhibition and/or Aspirin triggered lipoxins and resolvins in amelioration of COVID-19 mortality</a>
</div></li>
<li><strong>Synthesis of High-Resolution Research-Quality MRI Data from Clinical MRI Data in Patients with COVID-19</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Pathophysiological mechanisms of neurological disorders in patients with coronavirus disease 2019 (COVID-19) are poorly understood, partly because of a lack of high-resolution neuroimaging data. We applied SynthSR, a convolutional neural network that synthesizes high-resolution isotropic research-quality data from thick-slice clinical MRI data, to a cohort of 11 patients with severe COVID-19. SynthSR successfully synthesized T1-weighted MPRAGE data at 1 mm spatial resolution for all 11 patients, each of whom had at least one brain lesion. Correlations between volumetric measures derived from synthesized and acquired MPRAGE data were strong for the cortical grey matter, subcortical grey matter, brainstem, hippocampus, and hemispheric white matter (r=0.84 to 0.96, p≤0.001), but absent for the cerebellar white matter and corpus callosum (r=0.04 to 0.17, p&gt;0.61). SynthSR creates an opportunity to quantitatively study clinical MRI scans and elucidate the pathophysiology of neurological disorders in patients with COVID-19, including those with focal lesions.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.11.25.21266090v1" target="_blank">Synthesis of High-Resolution Research-Quality MRI Data from Clinical MRI Data in Patients with COVID-19</a>
</div></li>
<li><strong>Population-level changes in the mental health of UK workers during the COVID-19 pandemic: A longitudinal study using Understanding Society</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives The COVID−19 pandemic has substantially affected workers mental health. We investigated changes in UK workers mental health by industry, social class, and occupation and differential effects by UK country of residence, gender and age. Methods We used representative Understanding Society data from 6,474 adults (41,207 observations) in paid employment who participated in pre−pandemic (2017−2020) and at least one COVID-19 survey. The outcome was psychological distress (General Health Questionnaire-12; score≥4). Exposures were industry, social class and occupation and are examined separately. Mixed−effects logistic regression was used to estimate relative (OR) and absolute (%) increases in distress before and during pandemic. Differential effects were investigated for UK countries of residence (Non−England/England), gender (Male/female), and age (Younger/Older) using 3−way interaction effects. Results Psychological distress increased in relative terms most for professional, scientific and technical (OR:3.15, 95% CI 2.17−4.59) industry in the pandemic versus pre−pandemic period. Absolute risk increased most in hospitality (+11.4%). For social class, small employers/self−employed were most affected in relative and absolute terms (OR:3.24, 95% CI 2.28− 4.63; +10.3%). Across occupations Sales and customer service (OR:3.01, 95% CI 1.61− 5.62; +10.7%) had the greatest increase. Analysis with 3−way interactions showed considerable gender differences, while for UK country of residence and age results are mixed. Conclusions Psychological distress increases during the COVID−19 pandemic were concentrated among professional and technical and hospitality industries, small employers/self−employed and sales and customers service workers. Female workers often exhibited greater differences in risk by industry and occupation. Policies supporting these industries and groups are needed.
</p>
</div>
<div class="article-link article-html- link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.11.25.21266866v1" target="_blank">Population-level changes in the mental health of UK workers during the COVID-19 pandemic: A longitudinal study using Understanding Society</a>
</div></li>
<li><strong>Homeworking during the COVID-19 pandemic: Lessons for research and practice for sustainable (home)working in government</strong> -
<div>
During the COVID-19 pandemic, public servants in many countries were mandated to work from home. The unprecedented nature of the situation entailed considerable challenges for providing adequate HR support. In this study, we explored how Dutch public servants experienced mandatory homeworking by conducting a template analysis. Based on in-depth analyses of 985 written accounts, we inductively expanded an a priori template derived from the Job-Demands-Resource (JD-R) framework, to understand and analyze how public servants experienced their new situation. We found that components of mandatory homeworking trigger different experienced resources and demands with divergent consequences for different employees. Our study raises awareness about the effects of contextual factors, specifically personal background characteristics and working conditions, that are important to understand their divergent experiences with mandatory homeworking. Our findings are translated into propositions that extend the JD-R model. We end with lessons to create sustainable (home)working conditions in government.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/dshfp/" target="_blank">Homeworking during the COVID-19 pandemic: Lessons for research and practice for sustainable (home)working in government</a>
</div></li>
<li><strong>Rapid evaluation of COVID-19 vaccine effectiveness against VOC/VOIs by genetic mismatch</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Timely evaluation of the protective effects of COVID-19 vaccines is challenging but urgently needed to inform the pandemic control planning. Based on vaccine efficacy/effectiveness (VE) data of 11 vaccine products and 297,055 SARS-CoV-2 sequences collected in 20 regions, we analyzed the relationship between genetic mismatch of circulating viruses against the vaccine strain and VE. Variations from technology platforms are controlled by a mixed-effects model. We found that the genetic mismatch measured on the RBD is highly predictive for vaccine protection and accounted for 72.0% (p-value &lt; 0.01) of the VE change. The NTD and S protein also demonstrate significant but weaker per amino acid substitution association with VE (p-values &lt; 0.01). The model is applied to predict vaccine protection of existing vaccines against new genetic variants and is validated by independent cohort studies. The estimated VE against the delta variant is 79.3% (95% prediction interval: 67.0 - 92.1) using the mRNA platform, and an independent survey reported a close match of 83.0%; against the beta variant (B.1.351) the predicted VE is 53.8% (95% prediction interval: 39.9 - 67.4) using the viral-vector vaccines, and an observational study reported a close match of 48.0%. Genetic mismatch provides an accurate prediction for vaccine protection and offers a rapid evaluation method against novel variants to facilitate vaccine deployment and public health responses.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.22.21254079v2" target="_blank">Rapid evaluation of COVID-19 vaccine effectiveness against VOC/VOIs by genetic mismatch</a>
</div></li>
<li><strong>Covid-19 vaccination coverage and break through infections in urban slums of Bengaluru, India: A cross sectional study.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The ongoing pandemic of Corona virus disease 2019(covid 19) is caused by severe acute respiratory syndrome Corona virus 2(SAR COV 2). The world health organization declared it as public health emergency of international concern on January 2020 and later declared as pandemic on 11 March 2020.One of the high risk groups for COVID 19 disease are people residing in urban overcrowded slums and as most of the population is migrant, they are less aware of the pandemic and have less access to health care facilities. Vaccinating these high risk groups can decrease disease burden and control the ongoing pandemic. Objectives: 1] To estimate COVID 19 vaccination coverage 2] To assess the factors responsible for COVID 19 vaccination coverage and vaccine hesitancy 3] To study AEFI pattern following COVID 19 vaccination 4] To determine the prevalence of breakthrough infections after COVID 19 Vaccination in urban slums of Bengaluru, India. Methodology: A community based cross sectional study was conducted in Urban slums belonging to Urban Health and Training Centre, Department of community medicine, Akash Institute of Medical Sciences and Research Centre, Bengaluru Rural District, Karnataka, India. After obtaining Institutional ethical clearance and informed consent from study participants, data was collected from 1638 participants, fulfilling inclusion criteria using a predesigned, pretested, structured questionnaire. Data was entered in Microsoft excel and analyzed using SPSS version 24. Chi square test and Fischers exact test was applied and p &lt;0.05 considered as statistically significant. Results: In the present study, 35.5% (583 out of 1638) of the study participants had taken COVID Vaccine, of which 533 (91.42%) were partially vaccinated and remaining 50 (8.5%) were fully Vaccinated. Majority i.e. 98.45% have taken vaccine at Govt health centers. 63.65% vaccinated with Covishield reported adverse events, whereas 18.6% vaccinated with Covaxin reported adverse events. Adverse events were more likely to be reported by women (74.7%) compared to men (58.6%) , this observation was consistent across all age groups. Vaccination coverage was high among 18 to 45 years age group (37.75%), males (64.86%), Christians (47.05%) followed by Hindus (43.56%), graduates (95.67%), clerical and skilled workers (70.75%), Upper middle socioeconomic class (72.41%). This difference was statistically significant. Our study reported Break through infections in 7 out of total 583 vaccinated with a prevalence of 1.2%. The break through infections was very high among partially vaccinated (85.71%) as compared to fully vaccinated individuals (14.28%). This was observed among those vaccinated with Covaxin only. Conclusion: The COVID 19 vaccine coverage was low in urban slums. The prevalence of Break through infections in our study was higher as compared to available data/reports in the country. Break through infections was very high among partially vaccinated as compared to fully vaccinated individuals. This study on break through infections on COVID vaccination is first study in South India on general population. The most important factor for vaccine hesitancy is the occurrence of mild or serious adverse effects following immunization, and this may be the biggest challenge in the global response against the pandemic. Key words: COVID 19 vaccination, Break through infections, Vaccine hesitancy, Adverse events COVID vaccination, Urban slums
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.11.21.21262716v1" target="_blank">Covid-19 vaccination coverage and break through infections in urban slums of Bengaluru, India: A cross sectional study.</a>
</div></li>
<li><strong>Exploring the Temporal Dynamics of County-Level Vulnerability Factors on COVID-19 Outcomes</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
As the outbreak of COVID-19 has become a severe worldwide pandemic, every country fights against the spread of this deadly disease with incredible efforts. There are numerous researches along with every conceivable dimension for COVID-19. Among these researches, different demographic and contextual factors of populations and communities also play an essential role in providing more information for decision-makers. This paper mainly utilizes existing data on county contextual factors at the United States county-level to develop a model that can capture the dynamic trajectory of COVID-19 (i.e., cases) and its impacts across the United States. Moreover, our methods applied to contextual data achieves better results compared with existing measures of vulnerability.
</p>
</div>
<div class="article-link article- html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.11.24.21266757v1" target="_blank">Exploring the Temporal Dynamics of County-Level Vulnerability Factors on COVID-19 Outcomes</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the Effects of RO7496998 (AT-527) in Non-Hospitalized Adult and Adolescent Participants With Mild or Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: RO7496998;   Drug: Placebo<br/><b>Sponsor</b>:  <br/>
Hoffmann-La Roche<br/><b>Suspended</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mesenchymal Stem Cell Secretome In Severe Cases of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Injection of secretome - mesenchymal stem cell;   Other: Placebo;   Drug: Standard treatment of Covid-19<br/><b>Sponsor</b>:   Indonesia University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Allogenic UCMSCs as Adjuvant Therapy for Severe COVID-19 Patients</strong> - <b>Condition</b>:   Covid 19<br/><b>Interventions</b>:   Biological: Normoxic Allogenic UCMSC;   Other: Normal saline solution<br/><b>Sponsors</b>:   Kementerian Riset dan Teknologi / Badan Riset dan Inovasi Nasional, Indonesia;   Dr. Moewardi General Hospital, Surakarta, Indonesia;   Dr. Sardjito General Hospital, Yogyakarta, Indonesia;   Dr. Hasan Sadikin General Hospital, Bandung, Indonesia;   PT Bifarma Adiluhung<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Mild-to-Moderate COVID-19: A Phase II Clinical Trial</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: ExoFlo<br/><b>Sponsor</b>:   Direct Biologics, LLC<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Physical Fitness in Young Healthy Adults After COVID-19 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Other: Physical Activity Level;   Other: Evaluation of knee extension and elbow flexion muscle strength;   Other: Evaluation of functional strength of trunk muscles;   Other: Muscle Endurance;   Other: Flexibility;   Other: Balance;   Other: Fatigue<br/><b>Sponsor</b>:  <br/>
Baskent University<br/><b>Enrolling by invitation</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The South Proxa-Rescue AndroCoV Trial Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Proxalutamide;   Drug: Placebo<br/><b>Sponsors</b>:   Corpometria Institute;   Hospital da Brigada Militar de Porto Alegre, Porto Alegre, Brazil;   Hospital Arcanjo Sao Miguel, Gramado, Brazil;   Hospital Unimed Chapeco, Chapeco, Brazil<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vitamin D Supplementation and Clinical Improvement in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: Vitamin D3 10000 IU;   Dietary Supplement: Vitamin D3 1000 IU<br/><b>Sponsor</b>:   Bumi Herman<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Feasibility Pilot Clinical Trial of Omega-3 Supplement vs. Placebo for Post Covid-19 Recovery Among Health Care Workers</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Omega-3 (EPA+DHA);   Drug: Placebo<br/><b>Sponsor</b>:   Hackensack Meridian Health<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Controlled Trial of Angiotensin Receptor Blocker (ARB) &amp; Chemokine Receptor Type 2 (CCR2) Antagonist for the Treatment of COVID-19</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV2 Infection<br/><b>Interventions</b>:   Drug: Candesartan Cilexetil;   Drug: Repagermanium;   Drug: Candesartan Placebo;   Drug: Repagermanium Placebo<br/><b>Sponsors</b>:  <br/>
University of Sydney;   The George Institute for Global Health, India<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Partnerships to Address COVID-19 Inequities</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Crowdsourced campaign package;   Behavioral: Standard information<br/><b>Sponsor</b>:   Duke University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate the inHaled Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) On the Protective-Efficacy in Adults (SeiHOPE)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH);   Biological: Placebo<br/><b>Sponsors</b>:   CanSino Biologics Inc.;   Beijing Institute of Biotechnology<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pharmacokinetics, Pharmacodynamics, and Safety of Single-dose Sotrovimab in High-risk Pediatric Participants With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Sotrovimab<br/><b>Sponsors</b>:  <br/>
GlaxoSmithKline;   Vir Biotechnology, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PREVENT-COVID-19: A Q-Griffithsin Intranasal Spray</strong> - <b>Condition</b>:   COVID-19 Prevention<br/><b>Interventions</b>:   Drug: Q-Griffithsin;   Other: Placebo<br/><b>Sponsors</b>:   Kenneth Palmer;   United States Department of Defense<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhaled Recombinant Non-immunogenic Staphylokinase vs Placebo in Patients With COVID-19 - FORRIF Trial</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Recombinant nonimmunogenic staphylokinase;   Drug: Placebo<br/><b>Sponsors</b>:   Supergene, LLC;   Russian Academy of Medical Sciences<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nutritional Supplementation of Vitamin D, Quercetin and Curcumin With Standard of Care for Managing Mild Early Symptoms of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Standard of care;   Dietary Supplement: Investigational treatment<br/><b>Sponsor</b>:   King Edward Medical University<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In Silico Analysis of Bacteriocins from Lactic Acid Bacteria Against SARS-CoV-2</strong> - The COVID-19 pandemic caused by a novel coronavirus (SARS-CoV-2) is a serious health concern in the twenty-first century for scientists, health workers, and all humans. The absence of specific biotherapeutics requires new strategies to prevent the spread and prophylaxis of the novel virus and its variants. The SARS-CoV-2 virus shows pathogenesis by entering the host cells via spike protein and Angiotensin-Converting Enzyme 2 receptor protein. Thus, the present study aims to compute the binding…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current COVID-19 pandemic, has caused more than 4.5 million deaths worldwide. Severe and fatal cases of COVID-19 are often associated with increased proinflammatory cytokine levels including interleukin 6 (IL-6) and acute respiratory distress syndrome. In this study, we explored the feasibility of using plants to produce an anti-IL-6 receptor (IL-6R) monoclonal antibody (mAb) and examined its utility in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection</strong> - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells mainly by the angiotensin converting enzyme 2 (ACE2) receptor, which can recognize the spike (S) protein by its extracellular domain. Previously, recombinant soluble ACE2 (sACE2) has been clinically used as a therapeutic treatment for cardiovascular diseases. Recent data demonstrated that sACE2 can also be exploited as a decoy to effectively inhibit the cell entry of SARS-CoV-2, through blocking SARS-CoV-2 binding…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections</strong> - Cardiotonic steroids are steroid-like natural compounds known to inhibit Na<sup>(+)/K</sup>(+)-ATPase pumps. To develop a broad- spectrum antiviral drug against the emerging coronavirus infection, this study assessed the antiviral properties of these compounds. The activity of seven types of cardiotonic steroids against the MERS-CoV, SARS-CoV, and SARS-CoV-2 coronavirus varieties was analyzed using immunofluorescence antiviral assay in virus-infected cells. Bufalin, cinobufagin, and telocinobufagin showed…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2): Insights into Natural Products against COVID-19</strong> - In 2019, the world suffered from the emergence of COVID-19 infection, one of the most difficult pandemics in recent history. Millions of confirmed deaths from this pandemic have been reported worldwide. This disaster was caused by SARS- CoV-2, which is the last discovered member of the family of Coronaviridae. Various studies have shown that natural compounds have effective antiviral properties against coronaviruses by inhibiting multiple viral targets, including spike proteins and viral enzymes….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synthesis, Antimicrobial, Anticancer, PASS, Molecular Docking, Molecular Dynamic Simulations &amp; Pharmacokinetic Predictions of Some Methyl β-D-Galactopyranoside Analogs</strong> - A series of methyl β-D-galactopyranoside (MGP, 1) analogs were selectively acylated with cinnamoyl chloride in anhydrous N,N-dimethylformamide/triethylamine to yield 6-O-substitution products, which was subsequently converted into 2,3,4-tri-O-acyl analogs with different acyl halides. Analysis of the physicochemical, elemental, and spectroscopic data of these analogs revealed their chemical structures. In vitro antimicrobial testing against five bacteria and two fungi and the prediction of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms</strong> - Due to the scarcity of therapeutic approaches for COVID-19, we investigated the antiviral and anti-inflammatory properties of curcumin against SARS-CoV-2 using in vitro models. The cytotoxicity of curcumin was evaluated using MTT assay in Vero E6 cells. The antiviral activity of this compound against SARS-CoV-2 was evaluated using four treatment strategies (i. pre-post infection treatment, ii. co-treatment, iii. pre-infection, and iv. post-infection). The D614G strain and Delta variant of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jeopardy of COVID-19: Rechecking the Perks of Phytotherapeutic Interventions</strong> - The novel coronavirus disease (COVID-19), the reason for worldwide pandemic, has already masked around 220 countries globally. This disease is induced by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). Arising environmental stress, increase in the oxidative stress level, weak immunity and lack of nutrition deteriorates the clinical status of the infected patients. Though several researches are at its peak for understanding and bringing forward effective therapeutics, yet there is…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Natural Apocarotenoids and Their Synthetic Glycopeptide Conjugates Inhibit SARS-CoV-2 Replication</strong> - The protracted global COVID-19 pandemic urges the development of new drugs against the causative agent SARS-CoV-2. The clinically used glycopeptide antibiotic, teicoplanin, emerged as a potential antiviral, and its efficacy was improved with lipophilic modifications. This prompted us to prepare new lipophilic apocarotenoid conjugates of teicoplanin, its pseudoaglycone and the related ristocetin aglycone. Their antiviral effect was tested against SARS-CoV-2 in Vero E6 cells, using a cell…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System</strong> - Andrographispaniculata (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from A. paniculata, such as andrographolide and its analogs, have attracted much interest for their potential treatment against…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells</strong> - (1) Background: There is a strong need for prevention and treatment strategies for COVID-19 that are not impacted by SARS-CoV-2 mutations emerging in variants of concern. After virus infection, host ER resident sigma receptors form direct interactions with non-structural SARS-CoV-2 proteins present in the replication complex. (2) Methods: In this work, highly specific sigma receptor ligands were investigated for their ability to inhibit both SARS-CoV-2 genome replication and virus induced…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Insights into the SARS-CoV-2-Mediated Alteration in the Stress Granule Protein Regulatory Networks in Humans</strong> - The rapidly and constantly evolving coronavirus, SARS-CoV-2, imposes a great threat to human health causing severe lung disease and significant mortality. Cytoplasmic stress granules (SGs) exert anti-viral activities due to their involvement in translation inhibition and innate immune signaling. SARS-CoV-2 sequesters important SG nucleator proteins and impairs SG formation, thus evading the host response for efficient viral replication. However, the significance of SGs in COVID-19 infection…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Impact of Socialisation on Children’s Prosocial Behaviour. A Study on Primary School Students</strong> - CONCLUSIONS: The results are relevant and useful for the study of trends in prosocial behaviours among children. Family education level, individual status, peer interactions and social conditionings are variables that highly influence this multidimensional phenomenon. Further research is needed, including the definition of new measures and indicators concerning the context where children live and interact with others, with the aim of designing interventions aimed at facilitating relational…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impacts of p97 on Proteome Changes in Human Cells during Coronaviral Replication</strong> - Human coronavirus (HCoV) similar to other viruses rely on host cell machinery for both replication and to spread. The p97/VCP ATPase is associated with diverse pathways that may favor HCoV replication. In this study, we assessed the role of p97 and associated host responses in human lung cell line H1299 after HCoV-229E or HCoV-OC43 infection. Inhibition of p97 function by small molecule inhibitors shows antiviral activity, particularly at early stages of the virus life cycle, during virus…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease</strong> - Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (M^(pro)) of coronavirus plays a pivotal role in viral replication and transcription, which, in theory, is an attractive drug target for antiviral drug development. It has been extensively discussed whether Xanthohumol is able to help COVID-19 patients. Here, we report that Xanthohumol, a small molecule in clinical trials from…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>P2P 네트워크를 이용한 내장된 화상회의 시스템</strong> - 본 발명은 P2P 네트워크를 이용한 내장된 화상회의 시스템에 관한 것으로, 상태표시부(1), 영상송출부(2), 제어부(3), 광고부(4), 입력부(5)를 포함한다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR342781397">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A DOORBELL SYSTEM FOR MONITORING AND RECORDING A PHYSIOLOGICAL DATA OF A PERSON</strong> - AbstractTitle: A doorbell system for monitoring and recording a physiological data of a person The present invention provides a doorbell system 500 for monitoring and recording a physiological data of a person. The doorbell system 500 having a transmitter module 100 and a receiving module 200. The transmitter module 100 is having a TOF sensor module 110, an ultrasound detector 120, and an infrared detector 130. Further, a speech recognition system 150, a facial recognition system 160, and a temperature detector 190 are provided for recognizing speech, face, and temperature of the person by comparing pre-stored data. A controlling module 180 is set with a predefined commands for communicating with the transmitter module 100 and receiving module 200. The collected facial and speech data is compared and matched with the pre-stored data then the temperature detector 190 triggers and the door opens when the captured body temperature of the person is matched within the predefined range of temperature.Figure 1 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN340503637">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A study of contemporary trends in investing patterns, household savings, and economic investment.</strong> - Because household savings and household investments are intertwined and interdependent, they are discussed briefly in this paper. Household savings account for more than half of a country’s capital formation, which fluctuates due to a variety of economic factors such as inflation and interest rates. Households should gradually shift their savings and investments from physical assets to financial assets to avoid a sudden change in wealth. They should also save and invest using a variety of platforms. Trends in investing and saving will be easier to track and measure this way. This year’s domestic saving rate in India is 2.3 percent lower than last year’s and 1.2 percent lower than the year before. Since 2011, general domestic savings have been steadily declining, with the trend continuing into the following year. According to official data, the GDP in 2020 shrank by 23.9%, the least in previous years and the least since the Covid-19 pandemic in previous years. As a result, the information presented in this paper is drawn from and evaluated from other sources - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN340502149">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PROLIPOSOMAL DRY POWDER INHALER OF REMDESIVIR</strong> - The present invention is related to Proliposomal Dry Powder Inhaler of Remdesivir and its method thereof for the treatment of viral infections such Coronaviridae (including COVID-19 infection). - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN342291904">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Use of Diminazene Aceturate, Xanthenone, ACE 2 activators or analogs for the Treatment and therapeutic use of COVID-19 on human patients.</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU340325322">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACTIVE RIDER SAFETY SYSTEM FOR TWO WHEELERS</strong> - The present invention relates to an active rider safety system for two wheelers comprising, a protective case equipped by a user for riding, where the case is integrated with multiple piezoelectric sensor that determines fastening of the case by user, a processing unit linked to the sensor, where the unit detects absence of case upon fetching data from the sensor below a threshold value and thereby terminates operation of ignition by stopping a coupled motor operated via a radio frequency module, an alcohol detection sensor that detects presence of alcohol and send data to processing unit, a temperature sensor that measures temperature of the user, an accelerometer sensor that activates upon ignition us tuned on to determine presence of a crash and a navigation module that via communication module sends location of user to pre saved users and concerned authorities. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN340503361">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti-SARS-CoV-2 antibodies and uses thereof I</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU339290405">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti-SARS-CoV-2 antibodies and uses thereof II</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU339290406">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Secured Health monitoring system using cloud computing</strong> - As used in public health surveillance, the invention generally relates to remote health monitoring systems with cloud computing. This is particularly relevant about a multi-user remote health monitoring system that can detect and gather data from healthcare professionals on the ground and systems in laboratories and hospitals to help the public health sector. It is possible to utilize the system for tracking, monitoring, and collecting patient data and for querying and collecting more information on the health of the people. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN340500672">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bst DNA聚合酶重组突变体、其编码DNA及超快磁珠LAMP检测方法</strong> - 本发明在野生型Bst DNA聚合酶序列上进行了Ser358Asp、Thr480Asn、Asp533Glu、Ala539Gly几个点位的突变，然后将进行点突变后的Bst DNA聚合酶的292‑305的氨基酸EGLLKVVRPDTKKV替换成DPLPDLIHPRTLRL，在突变后Bst DNA聚合酶序列的C端融合了一个DNA结合蛋白，在突变后Bst DNA聚合酶序列的N端融合了一个HP47多肽序列（SEQ ID No.17），在HP47多肽序列前面融合了一个CL7‑SUMO‑Tag，得到一种具有高活性和热稳定性的Bst DNA聚合酶重组突变体Super‑Bst（SEQ ID No.16）。Super‑Bst在热稳定性、特异性、链置换能力、延伸能力和逆转录酶活性上得到了显著地提升，能够耐受高盐和各类抑制剂，且可以通过原核表达和亲和纯化大量获得。本发明还公开了其编码DNA，以及一种超快磁珠LAMP检测方法。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN341345614">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andrew Cuomo’s Downfall Began with a Book Deal</strong> - A new report details how the former New York governor forced aides to work on his lucrative pandemic memoir, and how that scandal connects to the others that brought him down. - <a href="https://www.newyorker.com/news/our-local-correspondents/andrew-cuomos-downfall-began-with-a-book-deal">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Russia Hasn’t Cracked Down on COVID-19</strong> - The country’s fragile political climate has repeatedly undermined its response to the pandemic. - <a href="https://www.newyorker.com/news/dispatch/why-russia-hasnt-cracked-down-on-covid-19">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reëxamining the Legacy of Race and Robert E. Lee</strong> - The historian Allen C. Guelzo believes that the Confederate general deserves a more compassionate reading. - <a href="https://www.newyorker.com/news/q-and-a/reexamining-the-legacy-of-race-and-robert-e-lee">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Best Music of 2021</strong> - I found myself pulled toward albums that were elemental, tender, free. - <a href="https://www.newyorker.com/culture/2021-in-review/the-best-music-of-2021">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kurt Gödel’s Loophole and Donald Trump’s Defiance</strong> - Enforcing the law is harder than it might seem when those having the law enforced against them have contempt for it. - <a href="https://www.newyorker.com/news/daily-comment/kurt-godels-loophole-and-donald-trumps-defiance">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>What you need to know about the omicron variant</strong> -
<figure>
<img alt="Travelers stand with their luggage in an airport terminal in Johannesburg, South Africa, on
November 27, 2021." src="https://cdn.vox-cdn.com/thumbor/q99FYR_jefpbAU_fOA9MewxubVQ=/247x0:4172x2944/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70199075/1236837087.0.jpg"/>
<figcaption>
Travelers queue at a check-in counter at OR Tambo International Airport in Johannesburg, South Africa, on November 27, 2021, after several countries imposed new travel restrictions following the discovery of the omicron Covid-19 variant. | Phill Magakoe/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Omicron is the newest Covid-19 “variant of concern,” according to the World Health Organization.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Hy3u4f">
A new Covid-19 variant, now named the <a href="https://www.cdc.gov/media/releases/2021/s1126-B11-529-omicron.html">omicron variant</a>, was detected in South Africa on Wednesday, prompting renewed concern about the pandemic, a major stock market drop, and the imposition of new international travel restrictions to stop the spread.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zMAkCi">
Though the variant’s existence was first reported by South Africa, it <a href="https://www.npr.org/sections/coronavirus-live-updates/2021/11/27/1059501446/covid-
coronavirus-omicron-variant">has also been found</a> in<strong> </strong>Belgium, Botswana,<strong> </strong>Germany, Hong Kong, Israel, Italy, and the United Kingdom, meaning the variant has already spread — though how far is unclear, as new cases continue cropping up around the world.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7Zo7sU">
While it will take scientists some weeks to understand the omicron variant, including how quickly it can spread and what the illness that results from infection looks like, the World Health Organization has already labeled omicron a “<a href="https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-
concern">variant of concern</a>,” <a href="https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/">meaning</a> it could be more transmissible, more virulent, or more able to evade the protection granted by vaccines than the original strain of Covid-19.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YQjBXI">
More information about the new variant is sure to emerge over the coming days and weeks, but here’s what experts are saying so far.
</p>
<h3 id="u4FYm4">
What do we know about the new variant?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9m9EgX">
Early evidence suggests that the omicron variant is highly contagious, possibly more so than the delta variant. With <a href="https://www.ft.com/content/42c5ff3d-e676-4076-9b9f-7243a00cba5e">more than 30 mutations on the spike protein</a> — the part of the virus that binds to a human cell, infecting it — omicron could both be more transmissible and have more mechanisms to evade immunity already conferred by vaccines or prior infection.
</p></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hCfqBx">
So far, cases of the variant have appeared primarily in young people, leaving them exhausted and with body aches and soreness, according to Dr. Angelique Coetzee, head of the South African Medical Association. “We’re not talking about patients that might go straight to a hospital and be admitted,” she told <a href="https://www.bbc.com/news/world-59442129">the BBC</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="toQnis">
Relative to its <a href="https://graphics.reuters.com/world-coronavirus-tracker-and-maps/countries-and-territories/south-africa/">pandemic peak</a>, cases in South Africa are relatively low right now. However, the country has still seen a substantial spike in new infections: On Friday, South Africa reported new 2,828 Covid-19 cases, <a href="https://apnews.com/article/coronavirus-pandemic-joe-biden-science-health-
lifestyle-83cad19ead1725137bd7c3a371792ab7">according to the Associated Press</a>, with as many as 90 percent of those cases potentially caused by the omicron variant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6wgljj">
Reinfection is also concern with the new variant, <a href="https://www.nature.com/articles/d41586-021-03552-w/">according to the journal Nature</a>, but at this early stage, it’s difficult to tell how likely reinfection or breakthrough infections actually are.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xtd6ru">
“The mutation profile gives us concern, but now we need to do the work to understand the significance of this variant and what it means for the response to the pandemic,” Dr. Richard Lessells, an infectious disease expert at University of KwaZulu-Natal in Durban, South Africa, said at a South African health ministry press conference on Thursday.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jRj3j0">
Whether the efficacy of treatments such as monoclonal antibodies — and <a href="https://www.vox.com/future-
perfect/22772612/early-treatment-for-covid-fluvoxamine-molnupiravir-paxlovid">new pill treatments</a> from Pfizer and Merck — will be the same against the omicron variant is also unclear, as is the new variant’s virulence, or how sick it will make those infected, Dr. Leana Wen, a professor of public health at George Washington University, <a href="https://twitter.com/DrLeanaWen/status/1464615112816353322?s=20">told CNN’s Jim Acosta on Friday</a>.
</p>
<div id="oBb7ce">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
3 key Qs about new <a href="https://twitter.com/hashtag/covid19?src=hash&amp;ref_src=twsrc%5Etfw">#covid19</a> variants:<br/>1) Is it more contagious?<br/>2) Is it more virulent?<br/>3) Is there immune escape?<br/>Lots unanswered re Omicron, but the Biden admin had to act. Imagine the outcry if they did not institute a travel ban &amp; this variant took hold in the US. <a href="https://twitter.com/Acosta?ref_src=twsrc%5Etfw"><span class="citation" data-cites="Acosta">@Acosta</span></a> <a href="https://t.co/EJvFQuhTR2">pic.twitter.com/EJvFQuhTR2</a>
</p>
— Leana Wen, M.D. (<span class="citation" data-cites="DrLeanaWen">@DrLeanaWen</span>) <a href="https://twitter.com/DrLeanaWen/status/1464615112816353322?ref_src=twsrc%5Etfw">November 27, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IfZdyl">
<a href="https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-
cov-2-variant-of-concern">According to the WHO</a>, the earliest known case of the omicron variant was November 9, and the mutation was first detected November 24 in South Africa, which has an advanced detection system. While the delta variant is still the dominant strain worldwide and <a href="https://www.reuters.com/world/how-worried-should-we-be-
about-omicron-variant-2021-11-27/">accounts for for 99.9 percent of cases in the US</a>, the discovery of the omicron variant has coincided with a spike in South African cases — a 1,124 percent increase over the past two weeks, <a href="https://www.nytimes.com/interactive/2021/world/covid-cases.html">according to the New York Times</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Nx2kve">
However, the variant has likely spread far more widely than South Africa, according to the US’s top infectious disease expert, Dr. Anthony Fauci. “When you have a virus that’s showing this degree of transmissibility &amp; you’re having travel-related cases…it almost invariably is going to go all over,” NBC reporter Kaitlan Collins <a href="https://twitter.com/kaitlancollins/status/1464607176744386564?s=20">tweeted Saturday</a>, quoting Fauci.
</p>
<div id="J3Yc2D">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Fauci says the Omicron variant hasn’t been detected in US but he wouldn’t be surprised if it’s already here. “When you have a virus that’s showing this degree of transmissibility &amp; you’re having travel-related cases…it almost invariably is going to go all over,” he tells NBC.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">— Kaitlan Collins (<span class="citation" data-cites="kaitlancollins">@kaitlancollins</span>) <a href="https://twitter.com/kaitlancollins/status/1464607176744386564?ref_src=twsrc%5Etfw">November 27, 2021</a></p>
</blockquote>
</div>
<h3 id="PcCKTF">
What are governments doing to contain the new variant?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tyrjjK">
On Friday, President Joe Biden announced new travel restrictions <a href="https://www.whitehouse.gov/briefing-
room/presidential-actions/2021/11/26/a-proclamation-on-suspension-of-entry-as-immigrants-and-nonimmigrants-of-certain-
additional-persons-who-pose-a-risk-of-transmitting-coronavirus-disease-2019/">on eight southern African countries</a>, which will take effect on Monday. Travel from Lesotho, South Africa, Eswatini, Namibia, Zimbabwe, Mozambique, Malawi, and Botswana will be restricted, though those restrictions won’t apply to US citizens or green card holders, among other groups.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r5YPiB">
<a href="https://twitter.com/DrLeanaWen/status/1464615112816353322?s=20">As Wen said on Friday</a>, travel bans don’t necessarily do much overall to prevent the spread of the virus, but they can buy time for governments to learn more about diseases and variants and better protect their populations.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Idwmsk">
“I’ve decided that we’re going to be cautious,” <a href="https://www.whitehouse.gov/briefing-room/speeches-
remarks/2021/11/26/remarks-by-president-biden-in-press-gaggle-2/">Biden told reporters</a> on Friday. “But we don’t know a lot about the variant except that it is of great concern; it seems to spread rapidly.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xo7DAS">
Other nations — the UK, Singapore, Israel, France, and Germany <strong>—</strong> are also <a href="https://www.bbc.com/news/world-59442129">restricting travel</a> from southern African nations in an effort to contain the new variant, despite criticism from the South African government.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jxqUru">
“This latest round of travel bans is akin to punishing South Africa for its advanced genomic sequencing and the ability to detect new variants quicker,” South Africa’s foreign ministry said in a <a href="http://www.dirco.gov.za/docs/2021/covid-19_1127.htm">Saturday statement</a>. “Excellent science should be applauded and not punished.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vdmVzP">
As of Saturday<strong> </strong>the US has not imposed any new travel restrictions on the European or Asian nations where the omicron variant has appeared.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rrav5a">
In addition to imminent travel restrictions on a number of southern African nations, Biden <a href="https://apnews.com/article/coronavirus-pandemic-new-variant-southern-africa-
omicron-33fa0983af6c9f961a186f4f4bb1147d">urged vaccination and boosters</a> for US citizens as a response to the new variant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tUH4p8">
To that end, Biden on Friday also <a href="https://www.whitehouse.gov/briefing-
room/statements-releases/2021/11/26/statement-by-president-joe-biden-on-the-omicron-covid-19-variant/">called on wealthy countries</a> with the capability to donate vaccines to do so to low- and middle-income countries, as well as to waive intellectual property rights on current vaccines and treatments so that poorer countries can produce generic versions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ErytiD">
Accessibility isn’t the only issue when it comes to a global vaccination campaign, however. Vaccine hesitancy has proven to be a global problem, including in South Africa, where last week the government asked drug companies to <a href="https://www.bloomberg.com/news/articles/2021-11-24/s-africa-wants-j-j-pfizer-vaccine-delivery-
delay-news24-says">delay delivery of new vaccine doses</a> in response to declining demand, despite only 35 percent of its adult population being inoculated. Europe is presently struggling with a new outbreak at least partly due to its <s>this </s>uneven vaccine uptake and <a href="https://www.nytimes.com/2021/11/17/world/europe/covid-vaccine-germany-
europe.html">vaccine resistance</a>.
</p>
<h3 id="YLPbKQ">
How concerned should I be?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Lmv7qa">
Omicron is likely <a href="https://www.reuters.com/world/how-worried-should-we-be-about-omicron-variant-2021-11-27/">already in the US</a>, given the loosened restrictions on international travel earlier in the month and the fact that the variant dates at least as far back as November 9. And even if it’s not yet, it soon will be, experts say.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="98APoj">
“It’s not going to be possible to keep this infection out of the country,” Fauci told the <a href="https://www.nytimes.com/live/2021/11/26/world/covid-vaccine-boosters-variant">New York Times</a>. “The question is: Can you slow it down?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dc5bCp">
While there are still many unknowns about the omicron variant, experts agree that it’s a troubling development in the Covid-19 pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y5LEVp">
“We’ve seen variants come and go, and every month or two we hear about one,” Dr. Ashish Jha, the dean of the Brown University School of Public Health, <a href="https://twitter.com/NewsHour/status/1464372531075469312?s=20">told PBS on Friday</a>. “This one is concerning. This one is different. There are a lot of features here that have me and many of us concerned about this.”
</p>
<div id="iW4wqC">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
What do we know at this point about the omicron variant of the coronavirus?<a href="https://twitter.com/ashishkjha?ref_src=twsrc%5Etfw"><span class="citation" data-cites="ashishkjha">@ashishkjha</span></a> joins <a href="https://twitter.com/WmBrangham?ref_src=twsrc%5Etfw"><span class="citation" data-cites="WmBrangham">@WmBrangham</span></a> to provide information and perspective. <a href="https://t.co/6SA50U5NPl">https://t.co/6SA50U5NPl</a> <a href="https://t.co/ToWzGWhkfH">pic.twitter.com/ToWzGWhkfH</a>
</p>
— PBS NewsHour (<span class="citation" data-cites="NewsHour">@NewsHour</span>) <a href="https://twitter.com/NewsHour/status/1464372531075469312?ref_src=twsrc%5Etfw">November 26, 2021</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Kmh31R">
Delta, the current dominant strain of the virus, shows heightened transmissibility and an ability to evade antibodies, as <a href="https://www.vox.com/22547537/delta-coronavirus-variant-covid-19-vaccines-masks-
lockdown">Vox’s Umair Irfan explained in June</a>. But as with delta, the key to limiting omicron’s spread depends upon human behavior and people’s willingness to engage with proven public health responses.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="flzR5z">
Stopping the spread also means stopping the possibility of harmful mutations to the virus. Mutations — changes to the makeup of the virus — are bound to happen, and many of them are harmless to people. The more opportunities the virus has to spread, however, the more chance it has to mutate into a variation that spreads faster, is more resistant to antibodies and treatments, or creates worse health outcomes — or even all of these negative traits.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iCgeFm">
Existing tools, however, should still be effective in stopping omicron<strong> </strong>— PCR tests appear to detect the variant, <a href="https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.1.529)-sars-cov-2-variant-of-
concern">according to the WHO,</a> and Francis Collins, the director of the National Institutes of Health, <a href="https://www.npr.org/2021/11/26/1059391761/dr-francis-collins-on-what-we-know-about-the-omicron-variant-so-
far">told NPR on Friday</a> that “there is no data at the present time to indicate that the current vaccines would not work [against omicron].”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l6O6uN">
Additionally, masking and social distancing both are proven strategies to stop the spread of Covid-19, as are getting vaccinated and getting a booster shot.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tLlWyq">
Those steps are especially crucial as the holiday season and cold weather bring people together indoors, where transmission occurs. According to the <a href="https://www.nytimes.com/interactive/2021/us/covid-cases.html">New York Times’ Covid-19</a> tracker, cases in the US have increased 10 percent over the past two weeks, with a daily average of 87,195 new cases, 52,279 hospitalizations, and 1,013 deaths. As of <a href="https://www.nytimes.com/interactive/2020/us/covid-19-vaccine-
doses.html">November 24, almost 75 percent of vaccine-eligible Americans</a> have received at least one vaccine dose.
</p>
<ul>
<li><strong>One Good Thing: How fashion became a part of The Nanny’s legacy</strong> -
<figure>
<img alt="Fran Drescher wearing an orange leather jacket and matching pants while holding a small dog." src="https://cdn.vox-cdn.com/thumbor/cs1YgqfpIVZ6h8jBV3ucFKtZzbc=/0x437:4699x3961/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70197984/GettyImages_1041653702.0.jpg"/>
<figcaption>
Fran Fine’s fashion- forward flair is the perfect gateway to a greater appreciation of the iconic ‘90s comedy television series. | CBS via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Fran Fine has remained a style icon for a generation of kids born during (and after) the years that the series aired.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MwtiSR">
The often-used meme, “I watched it for the plot,” is an irony-laden acknowledgment that we, as viewers, often gravitate toward eye candy. Most people prefer to watch flashy productions and beautiful celebrities over “highbrow” content; they have a knack for avoiding convoluted plot lines that force the viewer to think. This is not an incrimination but a very real aspect of our media consumption. Even Netflix’s official social media accounts have <a href="https://twitter.com/NetflixGeeked/status/1445503667147194373">leaned</a> into the joke to promote shows like <em>Squid Game</em>. “<a href="https://www.tiktok.com/@netflix/video/7012760687072021765?lang=en&amp;is_copy_url=1&amp;is_from_webapp=v1">The plot</a>,” then, becomes a teasing reference to its attractive cast instead of to the show’s unsubtle statement on social class in South Korea.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5htyNm">
Similarly, my interest in <em>The Nanny</em>, a CBS sitcom that aired from 1993 to 1999, stemmed from its superficial, plotless elements — or so I thought. I began streaming the show not for its comedic charm but the extravagant and colorful designer costumes worn by its main character, Fran Fine, the titular nanny (played by Fran Drescher).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="985ObC">
That isn’t to say <em>The Nanny</em> is all style with no substance. Instead, Fran’s fashion-forward flair was the gateway to my greater appreciation of the series and its tendency for excess through its comedy and aesthetics. The Nanny, both the show and the character, excelled at endearingly doing the most: Yiddish references pepper Fran’s vocabulary; she manages to be brash and self-deprecatingly honest, sweet but not cloying; and her clothes are ridiculously ostentatious for nanny-ing around the house.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="obqg3f">
Fran’s costumes, engineered by stylist Brenda Cooper (who <a href="https://www.emmys.com/bios/brenda-
cooper">won an Emmy</a> for her work), were the stylistic vehicle to distinguish her vivacious character from the rest of the well-rounded cast. <em>The Nanny</em>’s catchy, show-tune-like theme song even sets the audience up for this distinction. Fran is described as “the lady in red while everybody else is wearing tan.”
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q3sfkr">
To recap, <em>The Nanny</em> follows Fran Fine, a Jewish lady from Flushing, Queens, who, after losing her job at a bridal shop, accidentally lands a job as the nanny for the high-society, WASP-y Sheffield family. Her over-the-top persona (and nasally intonation) was initially bewildering to Maxwell, the widowed single dad of the family, but became endearing as he realized how smoothly his three children had taken to Fran’s antics. She moves in with the Sheffields and their snarky live-in butler Niles, and she playfully contends with Maxwell’s clingy and haughty business partner, C.C. Babcock.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Mi1DWy">
From the start of the show’s run to its sixth season finale, Fran remains its centrifugal force; her bubbly charm blew fresh air into the stuffy lives of the Sheffields, who viewers grow to individually adore. But Drescher, the series’ creator, and Cooper weren’t so sure <em>The Nanny </em>would’ve established such a beloved and lasting legacy if not for Fran’s clothes. “Could you imagine if I dressed that show and dressed Fran like an average, everyday nanny?” Cooper <a href="https://www.huffpost.com/entry/the-nanny-wardrobe-brenda-cooper_n_5ac79807e4b09d0a119343b6">told the HuffPost</a> in 2018. “We wouldn’t be having a conversation right now.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UiUs3v">
Cooper, until her departure after season four, was famously given free rein by Drescher to dress Fran Fine however she wished. She crafted Fran’s costumes to be an extension of her personality while also serving as memorable timestamps for the show’s progression and class commentary. Fran famously carried a <a href="https://thefinenanny.tumblr.com/post/112908066369/how-the-f-could-fran-
afford-a-moschino-bag-with">red Moschino heart-shaped purse</a> on a (failed) date with a mobster in season one and wore a <a href="https://www.instagram.com/p/BHC5xaMgHcq/?hl=en">Moschino piano dress</a> in a season four episode that featured an aspiring concert pianist who later lost any desire to play the instrument.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FhG7Qz">
Still, her character is a “shopaholic striver with a mountain of credit card debt,” <a href="https://www.newyorker.com/culture/on-
and-off-the-avenue/fran-drescher-in-the-nanny-is-the-fashion-look-this-fall">observed</a> Rachel Syme in the New Yorker, “a profligate clotheshorse who, the viewer assumes, cares more about materialist trends than timeless art.” Even after Fran’s induction into the Sheffield clan, her style remains singular, unswayed by the social expectations of the Upper East Side.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5mf4t6">
In a 2020 <a href="https://www.youtube.com/watch?v=zO8_AV68lsg">interview</a> with Vogue, Drescher described Fran’s style as “sexy, but definitely not trashy” and shared some of Cooper’s costuming decisions. The character wore a lot of Moschino, since the clothes had pizzazz and humor, according to Drescher. And in the scenes Fran shared with C.C., the goal was to depict the two women as “contrasting in every way, as people and in the way they dressed.” By today’s ’90s-obsessed standards, Fran’s looks are distinctly modern <em>and</em> timeless.
</p>
<figure class="e-image">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><img alt="On the set of The Nanny, Fran Drescher (as Fran Fine) sits on the
couch and reads a magazine, while Lauren Lane (as C.C. Babcock) stands and holds a newspaper." src="https://cdn.vox-
cdn.com/thumbor/ZJD7BMxYJU0kyocRgV2h-vZLte8=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23027568/GettyImages_136877595.jpg"/> <cite>CBS via Getty Images</cite></p>
<figcaption>
In the scenes Fran shared with C.C., Maxwell’s clingy and haughty business partner, the goal was to depict the two women as “contrasting in every way, as people and in the way they dressed.”
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PmqG1c">
Yet, <em>The Nanny</em> never achieved the level of widespread popularity and cultural cachet afforded to other ’90s shows, like <em>Friends</em> or <em>Sex and the City</em>. Female leads like Rachel Green and Carrie Bradshaw have remained style flashpoints for a generation of ’90s and 2000s kids born during the years their shows aired. <em>The Nanny, </em>on the other hand, became lauded and referenced by a much smaller audience (<a href="https://www.instagram.com/p/BoEiW-Ch4pM/?utm_source=ig_embed">including Cardi B</a>) in the decades after it went off the air. Various women’s and fashion publications have dedicated coverage to Fran’s unique fashion sensibilities in recent years, nearly two decades after the show ended (and before <em>The Nanny</em> was revived via streaming service). This interest was, in part, driven by the <a href="https://www.instagram.com/whatfranwore/?hl=en"><span class="citation" data-cites="whatfranwore">@whatfranwore</span></a> Instagram account, which identifies Fran’s iconic wardrobe to over 350,000 followers. The series’s arrival on HBO Max in April 2021, however, has likely introduced the show to more viewers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aqWrRQ">
It is also a step toward memorializing its cultural status as a ’90s sitcom. To viewers in 2021, the show’s set-up — its punchlines and the way it was filmed — might feel a bit dated. Not so much that the humor was corny, but that it was simply of a different time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jHQWOw">
Some seasons of <em>The Nanny </em>were taped before a live audience, which has become “a class signifier of comedy itself,” according to <a href="https://www.npr.org/transcripts/995528424">NPR’s Linda Holmes</a> on Pop Culture Happy Hour, “that somehow [a live audience laughing is] a less sophisticated or old-fashioned or more broad kind of comedy.” Still, the show boasted a list of enviable celebrity cameos during its run, featuring Elton John, Celine Dion, Elizabeth Taylor, Patti LaBelle, and of course, Donald Trump.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iyEey9">
<em>The Nanny</em> “finds jokes everywhere, sometimes three or four to a line, and links them across episodes and plotlines,” wrote Hilarie Ashton for the <a href="https://www.nytimes.com/2021/05/14/arts/television/nanny-hbo-max.html">New York Times</a>. Its self-aware, slapstick humor is refreshing and explicit for a decades-old show, and it generally holds up as a breezy ’90s sitcom to stream. <em>The Nanny</em>’s embrace of excess, however, had the potential to be wholly liberating and ahead of its time, but the show’s writers (and likely Drescher herself) drew the line at fatness. Instead, oversized bodies are to be feared or laughed at, and at one point in the series, Drescher dons a fat suit. In spite of this, Drescher’s charisma and comedic talent cement Fran Fine’s place in the television canon, as a lead who manages to <a href="http://www.slate.com/articles/arts/television/1998/02/my_nanny_problem.html">subvert and reinforce stereotypes</a> — about women, Jewishness, and class. <em>The Nanny </em>is a worthwhile watch for the cast’s physical humor, charm, and laugh-out-loud antics. But if you don’t find yourself convinced by these plot asides, do consider watching it solely for the clothes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y3RXmt">
The Nanny<em> is </em><a href="https://play.hbomax.com/series/urn:hbo:series:GYEkLVAeovrHCwgEAAAAW"><em>streaming on HBO Max</em></a><em>. For more recommendations from the world of culture, check out the </em><a href="https://www.vox.com/one-good-thing"><em>One Good Thing</em></a><em> archives.</em>
</p>
<ul>
<li><strong>Prices for food and gas are rising sharply. Is health care next?</strong> -
<figure>
<img alt="A finger balancing a wobbling board holding up hospital equipment and a pile of coins." src="https://cdn.vox-cdn.com/thumbor/rCmmqhthvjEoFGSF3wAXHMIl26Y=/240x0:2160x1440/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70197853/GettyImages_1224840122.0.jpg"/>
<figcaption>
iStock/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Health insurance premiums could spike in 2022, experts warn.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="artEje">
<a href="https://www.vox.com/the-goods/2021/11/10/22775092/inflation-cpi-october-economy-biden-
fed">Inflation</a> is on the rise, driving up the price of gas and food. One sector of the US economy is behaving particularly strangely: For once, medical prices have been increasing at a significantly lower rate than prices in the overall economy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jwbG7L">
In October 2021, according to <a href="https://altarum.org/sites/default/files/uploaded-publication-files/SHSS-Price-Brief_November_2021.pdf">the nonprofit health care analysis group Altarum</a>, prices for health care services rose at a 2 percent rate year-over- year, compared to a 6.2 percent rate for all consumer products.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0qA3mY">
But a sharp rise in medical prices could still be around the corner, experts say, delayed only because of unique features of the health care industry.
</p></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ir11Xr">
Over the last 30 years, consumer prices have almost never risen faster than medical inflation, which measures the change in the prices paid for medical services, everything from doctor’s visits to surgeries to prescription drugs. If anything, the opposite has been true, particularly during economic downturns; after the 2008 financial crisis, for example, overall inflation slowed down to almost nothing but medical prices continued to grow at a 2 to 3 percent rate.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vOUPSg">
In fact, since 2010, prices in the overall economy and in health care have moved more or less in tandem — until the spring of 2020.
</p>
<div class="c-float-right">
<figure class="e-image">
<pre><code> &lt;img alt="Chart: Growth rates of health industry versus GDP show GDP rising above in the pandemic" </code></pre>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">src=“https://cdn.vox-cdn.com/thumbor/TZL6sHjPLAORQ1-uWJx6lUCDB2s=/800x0/filters:no_upscale()/cdn.vox- cdn.com/uploads/chorus_asset/file/23037484/Screen_Shot_2021_11_23_at_10.36.34_AM.png” /&gt; <cite>Altarum</cite></p>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZSLqlx">
But while that may make it sound as though the health care sector is enjoying a welcome respite from the general inflation creating so much nervousness among businesses and political leaders, the reality appears less reassuring. This comparatively slow growth in medical prices could be a mirage. And if health care inflation does eventually catch up with the broader economy, patients would largely be the ones paying for it.
</p>
<h3 id="L7hi9R">
Why medical inflation could accelerate soon
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9tKH93">
The same problems driving up prices in the rest of the economy — rising costs within the supply chain, difficulty finding workers for open jobs — are issues in the health care sector too. The workforce crisis in particular is acute and not likely to go away any time soon, given how many nurses and doctors have left their jobs during the pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qikDEM">
A recent survey from the Chartis Group found that 99 percent of rural hospitals said they were experiencing a staffing shortage; 96 percent of them said they were having the most difficulty finding nurses. That has <a href="https://www.vox.com/coronavirus-
covid19/22763417/us-covid-19-hospitals-nurses-shortage">forced hospitals to increase their pay and benefits or hire temporary help</a> from travel nursing companies that are more expensive — sometimes much more expensive — than regular full-time staff. The costs for purchasing personal protective equipment and other supplies have also been elevated because of Covid.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PMx6tQ">
Hospitals are going to want to make up for those higher costs by bringing in more money. While the numbers of patients they served fell sharply in March and April of 2020, patient numbers are already back near their pre-pandemic levels. There are only so many ways to increase how many services they provide, especially amid a staffing crisis.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rc4rbu">
The other option is trying to charge health insurers more money for procedures and treatment, particularly the private insurers that directly negotiate prices with health care providers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ltx82j">
So while it might be a while before higher prices hit patients, they likely will — just on a time delay.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OfAdLH">
For medical services in particular, there is a lag between when the inflationary pressures like rising supply costs or labor shortages first appear and when they are actually felt in health care prices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4kqtpd">
In the rest of the economy, inflation and increased costs ripple through the market pretty quickly. If the cost of beef goes up today, the restaurant can raise the price of hamburgers tomorrow. If they can’t find fry cooks and need to increase wages to attract new workers, the restaurant can immediately charge more money for fries.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zj5arC">
But the prices for health care services are set in advance, written into binding contracts after negotiations between insurers and providers or after the government issues new regulations for public programs like Medicare. And those prices are generally set for an entire year, until another round of negotiations establishes new prices for the next year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MAFUXZ">
Altarum’s inflation experts told me the negotiations for 2022 plans will determine how much the current inflation crisis ends up affecting medical prices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7EsYSf">
These inflation-driving trends, like the rising workforce costs, have only accelerated throughout 2021. For the last decade, health care prices have consistently grown at roughly a rate of 1 percent to 2 percent. Already, in the last 18 months, prices for hospital and physician prices have exceeded a 3 percent inflation rate. Altarum’s experts say they are watching whether health care prices eventually increase at the same 5 percent to 7 percent rate currently being seen in the rest of the economy — which would be the fastest rate since 1993.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oA2cX1">
Such historic medical inflation would ultimately end up raising costs to patients in two distinct ways. First, if providers negotiate higher payments from insurers to make up for their increasing costs, the insurer will turn around and increase premiums for its customers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wvgQGF">
But patients also feel the rising costs more directly because they are being asked to pay more money out of pocket for their health care. Deductibles and other cost-sharing have been steadily rising for the 180 million Americans enrolled in commercial health plans. At the same time, the number of Americans considered underinsured — meaning they do carry insurance but the insurance would not necessarily provide them adequate financial protection if they had a medical emergency — has been growing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v8M5r0">
So if medical prices end up increasing at a historic rate, consumers are going to feel it both when they pay their premium and when they pick up their prescription: They’ll end up getting squeezed from both sides.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ind vs NZ 1st Test, Day 4 | Debutant Shreyas Iyer, gritty Wriddhiman Saha set up an intriguing final day</strong> - India declared at 234 for 7 for an overall lead of 283 and gave the Black Caps four tricky overs to face under fading light during which they managed four runs and lost opener Will Young to Ravichandran Ashwin</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watch | What happened to Chinese tennis star Peng Shuai?</strong> - A video on China’s tennis star Peng Shuai’s revelations of sexual assault and her consequent disappearance.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>WTA remains "concerned’ about Peng’s ability to speak freely</strong> - Peng, a three-time Olympian and former top-ranked doubles player, has dropped out of public view after accusing former vice-premier Zhang Gaoli of sexual abuse.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>LaLiga | Late goals ensure Barcelona win away at Villarreal</strong> - Barcelona’s victory followed a fortuitous 1-0 win over Espanyol last week in Xavi’s coaching debut and a goalless draw with Benfica in the Champions League in midweek</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>It’s Zuccarelli vs. Queen O’ War in Pune Derby</strong> - Zuccarelli and Queen O’ War should fight out the finish of the Pune Derby (Gr. 1), the blue riband event of the Pune racing season here on Sunday (Nov</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UPTET cancelled after paper leak, CM Adityanath says NSA will be invoked against culprits</strong> - U.P. Chief Minister Yogi Adityanath says, culprits involved in the UPTET paper leak will be booked under the National Security Act and Gangster Act</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Yellow alert in 10 districts</strong> - Rainfall is likely to be fairly widespread till Monday under the influence of a cyclonic circulation persisting over the Kanyakumari region and the co</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ED summons Amazon, Future Group executives in FEMA probe</strong> - The executives have been summoned along with documents for the coming week under the provisions of the Foreign Exchange Management Act (FEMA), say official sources</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ace mountaineer from Uttarakhand becomes first woman president of Indian Mountaineering Foundation</strong> - She has been honoured with the Arjuna award for her achievements in the field of mountaineering.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chennai grapples with traffic diversions as roads, subways brim with rain water</strong> - Reservoirs, including Poondi and Chembarambakkam that cater to the drinking water needs of Chennai, released over 10,500 cusecs of surplus water, authorities said.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Omicron Netherlands: 13 air passengers test positive for new variant</strong> - Thirteen people who travelled from South Africa to the Netherlands have tested positive for Omicron.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Calais activists: Migrants call us from boats asking for help</strong> - Activists in Calais demand change after decades of people coming to the city looking to reach the UK.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Covid: Swiss back government on Covid pass as cases surge</strong> - Sunday’s referendum is held in a country with one of the lowest vaccination rates in Western Europe.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Channel migrants: Emmanuel Macron and Boris Johnson clash over crisis</strong> - The French president accuses the UK prime minister of not being serious as diplomatic row escalates.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine-Russia conflict: Zelensky alleges coup plan involving Russians</strong> - He says an alleged plan to overthrow his government comes amid threats of a Russian invasion.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>This decorated mammoth ivory pendant is 41,500 years old</strong> - The pendant is the oldest example of a style that swept Paleolithic Europe. - <a href="https://arstechnica.com/?p=1816250">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The best smartwatches and fitness tracker deals for Black Friday weekend [Updated]</strong> - Many of our top wearable picks are seeing strong discounts this week. - <a href="https://arstechnica.com/?p=1815101">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The best Black Friday 2021 weekend deals on Apple devices</strong> - Apple’s gotten in on the Black Friday action, offering gift cards on many of its most popular devices. - <a href="https://arstechnica.com/?p=1815883">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Omicron quickly became a variant of concern</strong> - The WHO lets Omicron skip over variant of interest, go straight to concern. - <a href="https://arstechnica.com/?p=1816265">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>All the best Black Friday 2021 deals we can find that are still available [Updated]</strong> - We’ve cut through the Black Friday noise to find the deals worth your time. - <a href="https://arstechnica.com/?p=1815967">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A wife was in bed with her lover when she heard her husband’s key in the door. “Stay where you are,” she said, alarmed by the sound. “He’s so drunk he won’t even notice you’re in bed with me.”</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The husband lurched into bed, but a few minutes later, through a drunken haze, he saw six feet sticking out at the end of the bed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He turned to his wife: “Hey, there are six feet in this bed. There should only be four. What’s going on?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“You’re so drunk you miscounted,” said the wife. Get out of bed and try again. You can see better from over there.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The husband climbed out of bed and counted. One, two, three, four. Damn, you’re right.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Adi-Gill"> /u/Adi-Gill </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/r3kb4f/a_wife_was_in_bed_with_her_lover_when_she_heard/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/r3kb4f/a_wife_was_in_bed_with_her_lover_when_she_heard/">[comments]</a></span></p></li>
<li><strong>My Gf says I can get anal on my cake day if this post reaches front page</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Please upvote because I want to rearrange the whole house furnitures to make them perfectly symmetric from every angle.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/stupid_fucktard"> /u/stupid_fucktard </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/r3wg4k/my_gf_says_i_can_get_anal_on_my_cake_day_if_this/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/r3wg4k/my_gf_says_i_can_get_anal_on_my_cake_day_if_this/">[comments]</a></span></p></li>
<li><strong>Wife strikes again but stronger than before!</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A fireman comes home from work one day and tells his wife, "We had a wonderful system at the fire station:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Bell 1 rings, we put on our jackets;
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Bell 2 rings, we slide down the pole;
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Bell 3 rings, we’re on the trucks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
From now on, we’re going to run this house the same way.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
When I say Bell 1, I want you to strip naked.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
When I say Bell 2, I want you to jump into bed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
When I say Bell 3, we’re going to make passionate love."
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The next night, the fireman comes home from work and yells, “Bell 1!” His wife takes off her clothes.
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“Bell 2,” and his wife jumps into bed.
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“Bell 3,” and they began to make love.
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After two minutes, his wife yells, “Bell 4!”
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“What’s Bell 4?” the husband asks.
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“More hose,” she replies, "you’re nowhere near the fire
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Johmbest"> /u/Johmbest </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/r3t1ck/wife_strikes_again_but_stronger_than_before/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/r3t1ck/wife_strikes_again_but_stronger_than_before/">[comments]</a></span></p></li>
<li><strong>A man’s walking home late at night when he sees a woman in the shadows. “Twenty bucks,” she says. He’s never been with a prostitute before, but he decides what the hell. They are going at it for a minute when all of a sudden a light flashes on them—it’s a policeman.</strong> - <!-- SC_OFF -->
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“What’s going on here?” asks the officer.
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“I’m making love to my wife,” the man answers indignantly.
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“Oh, I’m sorry,” says the cop, “I didn’t know.”
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“Well,” said the man, “to tell the truth neither did I until you flashed that light on her face.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/r3vpf5/a_mans_walking_home_late_at_night_when_he_sees_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/r3vpf5/a_mans_walking_home_late_at_night_when_he_sees_a/">[comments]</a></span></p></li>
<li><strong>What’s the difference between sex and gender?</strong> - <!-- SC_OFF -->
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I don’t remember having gender with your mom.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/IlikeTNOmod"> /u/IlikeTNOmod </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/r3pjse/whats_the_difference_between_sex_and_gender/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/r3pjse/whats_the_difference_between_sex_and_gender/">[comments]</a></span></p></li>
</ul>
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