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+ + + ++Massive unemployment during the COVID-19 pandemic could result in an eviction crisis in US cities. Here we model the effect of evictions on SARS-CoV-2 epidemics, simulating viral transmission within and among households in a theoretical metropolitan area. We recreate a range of urban epidemic trajectories and project the course of the epidemic under two counterfactual scenarios, one in which a strict moratorium on evictions is in place and enforced, and another in which evictions are allowed to resume at baseline or increased rates. We find, across scenarios, that evictions lead to significant increases in infections. Applying our model to Philadelphia using locally-specific parameters shows that the increase is especially profound in models that consider realistically heterogenous cities in which both evictions and contacts occur more frequently in poorer neighborhoods. Our results provide a basis to assess municipal eviction moratoria and show that policies to stem evictions are a warranted and important component of COVID-19 control. +
+APTâą T3X on the COVID-19 Contamination Rate - Condition: Â COVID-19
Interventions:  Drug: Tetracycline hydrochloride 3%;  Drug: Placebo
Sponsors:  University of Nove de Julho;  Santa Casa de Misericórdia de Porto Alegre
Not yet recruiting
A Study of ORTD-1 in Patients Hospitalized With COVID-19 Related Pneumonia - Condition: Â COVID-19
Interventions:  Drug: ORTD-1 low dose;  Drug: ORTD-1 mid dose;  Drug: ORTD-1 high dose;  Other: Vehicle control
Sponsor:  Oryn Therapeutics, LLC
Recruiting
Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19 - Condition: Â COVID-19
Interventions:  Drug: Doxycycline Tablets;  Drug: Rivaroxaban 15Mg Tab;  Combination Product: Hydroxychloroquine and Azithromycin
Sponsor:  Yaounde Central Hospital
Recruiting
The Effect of Deep Breathing Exercise on Dyspnea, Anxiety and Quality of Life in Patients Treated for COVID-19 - Condition: Â COVID-19
Intervention:  Behavioral: Deep Breathing Exercise with Triflo
Sponsor:  Ankara University
Not yet recruiting
Pilot Study of Cefditoren Pivoxil in COVID-19 Patients With Mild to Moderate Pneumonia - Condition: Â COVID-19Â Pneumonia
Intervention:  Drug: Cefditoren pivoxil 400mg
Sponsor:  Meiji Pharma Spain S.A.
Recruiting
A Real World Study of Bamlanivimab in Participants With Mild-to-moderate Coronavirus Disease 2019 (COVID-19) - Condition: Â COVID-19
Intervention: Â Drug:Â Bamlanivimab
Sponsors:  Eli Lilly and Company;  AbCellera Biologics Inc.
Not yet recruiting
Study to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19 - Condition: Â COVID-19
Interventions: Â Drug:Â AT-527; Â Drug:Â Placebo
Sponsors:  Hoffmann-La Roche;  Atea Pharmaceuticals, Inc.
Not yet recruiting
Dexamethasone for COVID-19 - Condition: Â Covid19
Intervention: Â Drug:Â Dexamethasone
Sponsor:  University of Oklahoma
Not yet recruiting
Efficacy and Safety of DWJ1248 With Remdesivir in Severe COVID-19 Patients - Condition:  Severe COVID-19
Interventions:  Drug: DWJ1248 with Remdesivir;  Drug: Placebo with Remdesivir
Sponsor:  Daewoong Pharmaceutical Co. LTD.
Not yet recruiting
Assessment of Efficacy and Safety of Therapy With COVID-19 Convalescent Plasma in Subjects With Severe COVID-19 (IPCO) - Condition:  Severe COVID-19
Intervention:  Biological: COVID-19 convalescent plasma
Sponsor:  University of Erlangen-NĂŒrnberg Medical School
Recruiting
Mesenchymal Stem Cells Therapy in Patients With COVID-19 Pneumonia - Condition:  Coronavirus Disease 2019 (COVID-19) Pneumonia
Intervention:  Other: Mesenchymal stem cells
Sponsor: Â Kanuni Sultan Suleyman Training and Research Hospital
Completed
Study to Evaluate the Lot Consistency, Safety, Tolerability, and Immunogenicity of BNT162b2 Against COVID-19 in Healthy Adults - Conditions: Â SARS-CoV-2Â Infection; Â COVID-19
Intervention: Â Biological:Â BNT162b2
Sponsors:  BioNTech SE;  Pfizer
Not yet recruiting
The (HD)IVACOV Trial (The High-Dose IVermectin Against COVID-19 Trial) - Condition: Â Covid19
Interventions:  Drug: Ivermectin 0.6mg/kg/day;  Drug: Ivermectin 1.0mg/kg/day;  Drug: Placebo;  Drug: Hydroxychloroquine
Sponsor:  Corpometria Institute
Not yet recruiting
To Evaluate SCTA01 Treatment of High-risk Outpatients With COVID-19 - Conditions: Â COVID-19; Â SARS-CoV-2
Interventions: Â Drug:Â SCTA01; Â Other:Â Placebo
Sponsor:  Sinocelltech Ltd.
Not yet recruiting
Study of Adalimumab or Placebo in Patients With Mild to Moderate COVID-19 - Condition:  Mild to Moderate COVID-19
Interventions: Â Drug:Â Adalimumab; Â Drug:Â Placebo
Sponsors:  Ology Bioservices;  Pharm-Olam, LLC;  Chemical, Biological, Radiological, and Nuclear Medical
Not yet recruiting
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2 - Hydroxychloroquine, used to treat malaria and some autoimmune disorders, potently inhibits viral infection of SARS coronavirus (SARS-CoV-1) and SARS-CoV-2 in cell-culture studies. However, human clinical trials of hydroxychloroquine failed to establish its usefulness as treatment for COVID-19. This compound is known to interfere with endosomal acidification necessary to the proteolytic activity of cathepsins. Following receptor binding and endocytosis, cathepsin L can cleave the SARS-CoV-1 and...
Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformers - The coronavirus causing the COVID-19 pandemic, SARS-CoV-2, uses -1 programmed ribosomal frameshifting (-1 PRF) to control the relative expression of viral proteins. As modulating -1 PRF can inhibit viral replication, the RNA pseudoknot stimulating -1 PRF may be a fruitful target for therapeutics treating COVID-19. We modeled the unusual 3-stem structure of the stimulatory pseudoknot of SARS-CoV-2 computationally, using multiple blind structural prediction tools followed by ÎŒs-long molecular...
Fighting the storm: could novel anti-TNFalpha and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19? - The main aspects of severe COVID-19 disease pathogenesis include hyper-induction of proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory distress syndrome (ARDS) and often leads to death. COVID-19 patients often suffer from lung fibrosis, a serious and untreatable condition. There remains no effective treatment for these complications. Out of all cytokines, TNFα and IL-6 play crucial roles in cytokine storm pathogenesis and are likely responsible for the...
Purinergic Signaling of ATP in COVID-19 Associated Guillain-Barre Syndrome - Declared as a global public health emergency, coronavirus disease 2019 (COVID-19) is presented as a disease of the respiratory tract, although severe cases can affect the entire organism. Several studies have shown neurological symptoms, ranging from dizziness and loss of consciousness to cerebrovascular and neurodegenerative diseases. In this context, Guillain-Barré syndrome, an immune-mediated inflammatory neuropathy, has been closely associated with critical cases of infection with "severe...
Mass spectrometry reveals potential of beta-lactams as SARS-CoV-2 M(pro) inhibitors - The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some ÎČ-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.
Evaluation of the efficacy and safety of inhaled magnesium sulphate in combination with standard treatment in patients with moderate or severe COVID-19: A structured summary of a study protocol for a randomised controlled trial - OBJECTIVES: Basic and clinical studies have shown that magnesium sulphate ameliorates lung injury and controls asthma attacks by anti-inflammatory and bronchodilatory effects. Both intravenous and inhaled magnesium sulphate have a clinical impact on acute severe asthma by inhibition of airway smooth muscle contraction. Besides, magnesium sulphate can dilate constricted pulmonary arteries and reduce pulmonary artery resistance. However, it may affect systemic arteries when administered...
What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design - The emergence of a variety of coronaviruses (CoVs) in the last decades has posed huge threats to human health. Especially, the ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to more than 70 million infections and over 1.6 million of deaths worldwide in the past few months. None of the efficacious antiviral agents against human CoVs have been approved yet. 3C-like protease (3CL^(pro) ) is an attractive target...
Cytokine Profiles Before and After Immune Modulation in Hospitalized Patients with COVID-19 - We describe the cytokine profiles of a large cohort of hospitalized patients with moderate to critical COVID-19, focusing on IL-6, sIL2R, and IL-10 levels before and after receiving immune modulating therapies, namely, tocilizumab and glucocorticoids. We also discuss the possible roles of sIL2R and IL-10 as markers of ongoing immune dysregulation after IL-6 inhibition. We performed a retrospective chart review of adult patients admitted to a tertiary care center with moderate to critical...
Natural agents modulating ACE-2: A review of compounds with potential against SARS-CoV-2 infections - One of the biggest challenges of public health worldwide is reducing the number of events and deaths related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The angiotensin-converting enzyme 2 (ACE2), a carboxypeptidase that degrades angiotensin II into angiotensin 1-7, has been identified as a potent receptor for SARSCoV-2. In the last decades, ACE inhibition has assumed a central role in reducing cardiovascular and renal events. However, with the advent of COVID-19,...
An in silico analysis of Ibuprofen enantiomers in high concentrations of sodium chloride with SARS-CoV-2 main protease - 2020 will be remembered worldwide for the outbreak of Coronavirus disease (COVID-19), which quickly spread until it was declared as a global pandemic. The main protease (Mpro) of SARS-CoV-2, a key enzyme in coronavirus, represents an attractive pharmacological target for inhibition of SARS-CoV-2 replication. Here, we evaluated whether the anti-inflammatory drug Ibuprofen, may act as a potential SARS-CoV-2 Mpro inhibitor, using an in silico study. From molecular dynamics (MD) simulations, we also...
Molecular docking and simulation studies of natural compounds of Vitex negundo L. against papain-like protease (PL(pro)) of SARS CoV-2 (coronavirus) to conquer the pandemic situation in the world - The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is ÎČ-coronavirus that is responsible for the pandemic coronavirus disease 2019 (COVID-19) all over the world. The rapid spread of the novel SARS CoV-2 worldwide is raising a significant global public health issue with nearly 61.86 million people infected and 1.4 million deaths. To date, no specific drugs are available for the treatment of COVID-19. The inhibition of proteases essential for the proteolytic treatment of viral...
Withanolides from Withania somnifera as an immunity booster and their therapeutic options against COVID-19 - Traditionally, Withania somnifera is widely used as an immune booster, anti-viral, and for multiple medicinal purposes. The present study investigated the withanolides as an immune booster and anti-viral agents against the coronavirus-19. Withanolides from Withania somnifera were retrieved from the open-source database, their targets were predicted using DIGEP-Pred, and the protein-protein interaction was evaluated. The drug-likeness score and intestinal absorptivity of each compound were also...
Potential health benefits of zinc supplementation for the management of COVID-19 pandemic - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent for the Coronavirus Disease 2019 (COVID-19). The COVID-19 pandemic has created unimaginable and unprecedented global health crisis. Since the outbreak of COVID-19, millions of dollars have been spent, hospitalization overstretched with increasing morbidity and mortality. All these have resulted in unprecedented global economic catastrophe. Several drugs and vaccines are currently being evaluated, tested,...
Compounds of Citrus medica and Zingiber officinale for COVID-19 inhibition: in silico evidence for cues from Ayurveda - CONCLUSION: In silico studies suggest that the phytochemical compounds in C. medica and Z. officinale may have good potential in reducing viral load and shedding of SARS-CoV-2 in the nasal passages. Further studies are recommended to test its efficacy in humans for mitigating the transmission of COVID-19.
Factual insights of the allosteric inhibition mechanism of SARS-CoV-2 main protease by quercetin: an in silico analysis - SARS-CoV-2 main protease (M^(pro)) cleaves the viral polypeptide 1a and 1ab in a site-specific ((L-Q|(S, A, G)) manner and produce functional enzymes for mediating viral replication. Numerous studies have reported synthetic competitive inhibitors against this target enzyme but increase in substrate concentration often reduces the effectiveness of such inhibitors. Allosteric inhibition by natural compound can provide safe and effective treatment by alleviating this limitation. Present study deals...
COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS - - link
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
Covid 19 - Chewing Gum - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
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Die Erfindung betrifft ein FahrzeuglĂŒftungssystem (1) zum BelĂŒften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link
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Mund-Nasen-Bedeckung (1), wobei die Mund-Nasen-Bedeckung (1) mindestens an einem Ohr eines TrÀgers magnetisch befestigbar ist.
Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link
New York Cityâs Clown-Car Mayoral Race - More than thirty-five people are running for mayor. Does that bode well for the voters? - link
Living in the Age of the White Mob - The attack on the Capitol shows that white riotous violence, brutally epitomized by the Tulsa Race Massacre, has never been relegated to history. - link
The Trial of Donald Trump Must Tell the Full Story of the Capitol Insurrection - We need a truth-finding mission rather than just a punitive undertaking, and it requires the support of President-elect Biden. - link
Obituary for a Failed Presidency - In the end, Donald Trump was everything his haters fearedâa chaos candidate who became a chaos President. - link
Alexey Navalnyâs Fearless Return to Russia - The Russian dissidentâs superpower is his ability to show people what they have always known about the Putin regime but had the option of pretending away. - link
+Harris will become the first woman and first Black and South Asian American to serve as US vice president. +
++This is the first time a new US administration will be sworn in during a pandemic. The week-long procession of balls, dinners, concerts, and sheer jubilation has been waived under the threat of the virus. Just 2,000 people will be present for the inauguration, a far cry from the 1.8 million who attended Obamaâs first inauguration in 2009 and even the 1 million who attended his second in 2013. Congressional leadership, the Biden and Harris families, and other dignitaries will be in attendance, but theyâll be socially distanced on the risers â and masks will be a necessary feature. +
++Then add to those precautions the ones taken since a mob overran the US Capitol on January 6: an urgent âstay homeâ order from DC Mayor Muriel Bowser; an estimated 25,000 members of the National Guard on site, far outnumbering inauguration attendees; the National Mall remaining closed until January 21; Airbnb canceling all reservations in the District; local hotels housing active-duty military. The inauguration will look like no other in history. +
++But make no mistake: The significance of the moment canât be erased. Harris is Americaâs first woman vice president. The first vice president of Jamaican descent. The first vice president of Indian descent. Harris will bring her experiences as a Black and South Asian American woman to the vice presidency. Sheâs bringing Howard University and the Alpha Kappa Alphas with her; sheâs bringing her large blended family, along with the wisdom imparted to her by her late immigrant mother, Shyamala Gopalan, and late grandfather P.V. Gopalan. Inside the office of the vice president will be Orange Hill, Jamaica; Chennai, India; and Berkeley, California. America will have its first second gentleman: Doug Emhoff, the son of two Jewish parents from Brooklyn. +
++This is a major moment for America, its opportunity to finally confirm that women, particularly women of color, have helped cultivate the best version of America. This is Americaâs chance to honor and reward their image, their nonstop toil for opportunity. This is Americaâs moment to write a chapter that celebrates the diversity that makes it strong. +
++Harris has a big opportunity to help America confront some of its biggest ills. Her multiracial identity will hopefully force America to, if not confront the racism thatâs at the foundation of its division, then at least stretch the publicâs understanding of race. Her identity as a woman will unlock possibilities for other women across the country and help young minds imagine new dreams. +
++Harrisâs swearing-in will redefine the power of representation, a power that she acknowledged last summer. At the Black Girls Lead Conference in August, she told the attendees, âThere will be a resistance to your ambition. There will be people who say to you, âYou are out of your lane,â because they are burdened by only having the capacity to see what has always been instead of what can be. But donât you let that burden you.â +
++Harrisâs swearing-in makes representation in Americaâs second-highest office visible, tangible, and so much more real. +
++âWe have never had a vice president who was not a white man. By her very presence, Harris will shift the paradigm,â Kimberly Peeler-Allen, a co-founder of Higher Heights, an organization dedicated to increasing the political power of Black women, and visiting practitioner at the Center for American Women and Politics at Rutgers University, told Vox. âBiden has stated that he is looking for a real partner in governing. As that governing partner, Harris will draw on her full life experience as a Black woman in America and a law enforcement officer, a prosecutor, a diplomat, a legislator, to inform the decision-making process of the administration. This is a unique opportunity to uplift and draw focus to underrepresented, underresourced, and marginalized sectors of our society to create systemic change.â +
++Howard University political science professor Niambi Carter agrees that Harris will likely be âmore public-facingâ than past vice presidents, since both the pandemic and the calls for racial justice have created a new sense of urgency. Harris has âa real opportunity to not only lay the groundwork for bold policymaking in this administration but maybe also in her own administration if she chooses to run. This is a moment where bold leadership will be needed,â Carter told Vox. +
++America has only had a few examples of Black women in such high positions â thereâs never been a Black female governor, and only two Black women have held office in the US Senate, Carol Moseley Braun of Illinois and Harris. Harris made her commitment to improving communities of color clear while running for the Democratic presidential nomination in 2019. She advanced a Medicare-for-all plan and plans to help Black mothers, DREAMers, and Black people held back by the homeownership gap. But during a time when activists are calling for prison abolition and the abolishment of the police, many progressives also feel that because of her record as a prosecutor, she has a long way to go on criminal justice reform. It will be up to her to meet that challenge. +
++Harris is also taking office two weeks after insurrectionists violently scaled the Capitol scaffolding set up for the inauguration, casually replaced American flags with Confederate ones, and forcefully denied the outcome of the presidential election. White supremacy will likely never disappear, but her presence is a marker of defiance, a sign that thereâs always been a steady resistance. The new vice president can spearhead the effort to pass anti-racist policies that can help reverse inequality in America. +
++A depopulated inauguration, surrounded by an armed camp, may be an ominous start to Harrisâs vice presidency. Mothers who planned to accompany their daughters to the historic swearing-in will have to stay home. The National Mall, typically the site of smiling faces anticipating the inaugural parade, is instead decorated with flags that represent the millions of people who will be absent. The West side of the Capitol, which has been the site of the swearing-in for 40 years, is one of the few constants this year. +
++The pandemic has taught America that it can still stay connected â virtually. Years from now, weâll remember watching, from afar, Howard Universityâs famed Showtime Marching Band escort Vice President Harris during the inaugural parade. Weâll remember seeing, through our screens, the first Latinx Supreme Court Justice, Sonia Sotomayor, swear in the first Black and South Asian American vice president with a Bible that belonged to Thurgood Marshall, the first Black Supreme Court justice. +
++Harris is aware that any joy over the new administration is flanked by anxiety ahead of the inauguration â and she doesnât want that to ruin the moment. +
++She addressed the country in a video statement on Monday, saying, âI know this Inauguration Day may look a little different from years past â a lot different. Letâs take a moment to celebrate, and then letâs get to work building the America we know is possible.â +
++++#Inauguration2021 on Wednesday may look a little different from years past but itâs important we all take a moment to celebrate this historic moment. pic.twitter.com/WZGnkadiwo +
+â Kamala Harris (@KamalaHarris) January 19, 2021 +
+She also noted the hard work ahead for the nation. âOur country is on a path to heal and to rebuild. Of course, that doesnât mean the road ahead is going to be easy. Our nation continues to face challenges from the coronavirus pandemic to this economic recession, from our climate crisis to a long-overdue reckoning with racial injustice, to healing and strengthening the democracy that we all cherish.â +
++The pandemic, the Capitol riot, and racial justice are issues she is so far not running away from. She also canât run away from the communities in Georgia, Pennsylvania, Michigan, Nevada, Wisconsin, and Arizona that ushered in a Biden-Harris victory. The swearing-in of Kamala Harris remains historic, despite the smoke of white supremacy that wishes to blur the countryâs groundbreaking win. +
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++Social media abuse from political figures isnât just a Trump problem, and banning him wonât solve it. +
++Today would have been President Trumpâs last day with the special privileges Facebook and Twitter grant to world leaders, which exempt their speech from many of the platformsâ rules. But Trump managed to violate even those platformsâ most permissive policies with posts that encouraged violence at the United States Capitol, getting him kicked off them (and several others) entirely. At least for now, anyway; Facebook and Twitter can, as they always have, change the rules they made up. +
++Trumpâs ban came after years of the social media giants allowing him to push their limits, creating and adjusting their rules about world leaders to avoid having to take action against him â and to avoid positioning themselves as the arbiters of acceptable political speech. Citing the public interest and newsworthiness of almost anything world leaders had to say, Facebook and Twitter allowed them to break some of their rules. But not, as Trump discovered, all of them. +
++Trumpâs ban may have been in accordance with the platformsâ established policies, but deplatforming a world leader â especially this world leader â was still an extraordinary step. Twitter told Recode that Trump is the first head of state to be permanently suspended since the companyâs 2019 world leaders policy update. Trumpâs Twitter account is gone, along with all of his tweets. Facebookâs ban will definitely last until January 20 and is âindefiniteâ after that. His page is currently in a state of limbo: still up for all to see, but heâs not allowed to post anything on it. +
++Now that Facebook and Twitter have shown that they will set and enforce limits for the most powerful person in the world, it raises questions about how the companies will apply or change their policies for world leaders in the future, the relative harm or good their services have caused for democracy, and who theyâll deplatform next. +
++âI do agree with the decision [to ban Trump],â Deborah Brown, a senior researcher and digital rights advocate at Human Rights Watch, told Recode. âI donât necessarily agree with how we got there.â +
++Before Trump, social media platforms didnât see the need for defined policies or special rules for world leaders. Adam Sharp, Twitterâs founding head of news, government, and elections from 2010 until the end of 2016, told Recode that he often had to convince political figures to use the platform, ideally in a personal or authentic way that would make their constituents feel more connected to them. +
++Trump would need no such convincing. He already used social media â especially Twitter â the way a lot of people did: to blast out his notions and whims, however unsavory, to whoever was willing to read them. Trump wasnât dignified, he wasnât diplomatic, and he saw no need to change his behavior when he ran for and then became president. But the platforms couldnât have expected what would come next. +
++âI think there was an expectation that abuse would not be originating from these individuals,â Sharp said. âI canât really fault anyone, five years ago, for not thinking, âDo we need a policy for what happens if the president of the United States promotes an insurrection against the United States?ââ +
++After Trump was elected, Facebook and Twitter came out with their policies on posts that they saw as ânewsworthyâ or of âpublic interestâ â which was pretty much anything the president of the United States (or other world leaders) said on their platforms. This allowed him to threaten nuclear war with North Korea and call for a ban on all Muslims entering the United States. +
++Twitter became more restrictive in the latter half of Trumpâs presidency, placing notices on tweets from political figures that broke its rules, as well as limiting their spread. In October 2019, Twitter again laid out its policies regarding world leaders, including what content was still subject to their terms of service â that is, the exemptions to the world leader exemptions. Here, Twitter noted that its policies may change depending on the âincreasingly complex and polarized political culture.â The company also noted that âcontext mattersâ when it came to its decisions about threats of violence. +
++By 2020, both platforms were starting to push back on Trump as the election neared and the coronavirus pandemic raged. When Trump played up the possibility of fraud in voting by mail and played down the severity of the coronavirus, both platforms finally acted: Twitter appended fact-checks to misinformation about mail-in voting, and Facebook took down Trumpâs inaccurate post that children were immune to the coronavirus, for example. The platforms increasingly cracked down on other political figuresâ posts, too. Inaccurate posts about the coronavirus from Brazilâs president Jair Bolsonaro and Venezuelaâs president NicolĂĄs Maduro were pulled last March. +
++But the platforms avoided taking much â or any â action on Trumpâs posts that promoted violence. In June, he posted âwhen the looting starts, the shooting starts!â in response to the George Floyd protests. Twitter kept the tweet up but placed a notice on it, while Facebook did nothing. CEO Mark Zuckerberg would later say that while he understood the desire to remove some politiciansâ content, he still believed it was better that the public know what their leaders are saying. +
++Then Trump lost the election, only to insist, frequently and aggressively, that he won it and encourage his supporters to act before his win was âstolenâ from him. Facebook and Twitter said the world leader exemption would no longer apply to Trump once he left office, and likely counted down the days until their Trump problem solved itself. But Trump still managed to force the hands of platforms that dragged their feet to punish him. +
++âThis is not a change in policy â itâs a response to a specific situation based on risk,â Facebook told Recode of Trumpâs ban. âWe have established policies for dealing with praise of violence on the platform. They apply to all users around the world, including politicians.â +
++âWe made it clear going back years that these accounts are not above our rules and cannot use Twitter to incite violence,â Twitter told Recode. âWe will continue to be transparent around our policies, how they evolve, how they are enforced.â +
++Sharp has for years defended Twitterâs world leader policy, believing that itâs better for the world to see what its leaders have to say than for a private company to take on the job of sanitizing their timelines. +
++âIf the emperor doesnât have clothes, there should be a bright, burning-hot spotlight on it,â Sharp said. +
++After the election, though, Sharp saw less of a case that Trumpâs tweets informed his electorate, as the electorate had now made the informed decision to remove Trump from power. And Sharp now believes the same world leader status that made Trump exempt from many of Twitterâs rules also made his posts about the insurrection so uniquely destructive â and, therefore, finally actionable. +
++During and after the Capitol riots, Trump continued to push his narrative that the election was stolen from him and refused to condemn his supportersâ actions, and Facebook and Twitter responded by banning him temporarily, and then indefinitely. After all the words that Trump put on Twitter and Facebook, his ban came down to what was between the lines. His posts, on their face, were actually fairly tame by Trump standards. But the context around them â as well as the possibility that he would use their platforms to incite more violence â was what Twitter and Facebook took into account when making their decision to deplatform Trump. +
++Trumpâs social media exile was applauded by many, but some were also concerned that it could pave the way for deplatforming other world leaders or political speech â and that these decisions would be made by a few private companies with a demonstrably incredible amount of control and influence. +
++If Trump can get banned from Twitter and Facebook, it stands to reason that any world leader can be, too. But itâs not yet clear if the platforms will change their policies or how aggressively they will enforce them now. Two world leaders that are widely seen as likely to be banned â or who some think should be the next to be banned â are Bolsonaro and Iranâs Ayatollah Ali Khamenei. +
++Bolsonaro, who has modeled his presidency on Trumpâs and has run afoul of Twitterâs and Facebookâs rules, seems to be preparing for the possibility. After Trump was banned, Bolsonaro encouraged his Twitter and Facebook followers to follow him on Telegram. Khamenei, whose unverified accounts post Holocaust denials and call for the destruction of Israel, is frequently held up as an example of Twitterâs and Facebookâs double standards when they regulate Trumpâs speech. Khamenei remains on the platforms â which his own people donât have access to, as Twitter and Facebook are banned in Iran â but Twitter recently removed one of his tweets promoting coronavirus misinformation, and according to Khamenei, Facebook removed the Arabic-language version of his page (heâs since made a new one). +
++Several world leaders have meanwhile criticized social media companiesâ banning of Trump. Germanyâs Angela Merkel called it âproblematicâ to freedom of opinion, while Mexicoâs AndrĂ©s Manuel LĂłpez Obrador, who has called the results of his own election defeats into question, said he didnât agree with the idea of private companies punishing speech. +
++âIt should concern everyone when companies like Facebook and Twitter wield the unchecked power to remove people from platforms that have become indispensable for the speech of billions â especially when political realities make those decisions easier,â American Civil Liberties Union (ACLU) senior legislative counsel Kate Ruane said in a statement. âIt is our hope that these companies will apply their rules transparently to everyone.â +
++Civil and digital rights advocates hope that the platforms will use this as an opportunity to examine how they police political speech and the significant role their services play in the world, where theyâve been weaponized against certain groups, platformed several countriesâ disinformation campaigns, and become a recruitment tool for terrorists. When Facebook and Twitter did act to stop some of these abuses of their platforms, they often came too late and after ignoring plenty of warning. +
++âFrom my perspective, this raises larger questions around how platforms deal with the speech of politicians,â said Brown of Human Rights Watch. âThis shows the need to rethink these policies, to look at whether giving politicians so much free rein to violate policies is actually contributing to harm, and looking at the dynamics in the different countries or people using their platforms.â +
++Brown said she hoped the platforms would do this proactively, rather than reactively. And she hopes that lesser-known instances of social media abuse by political figures are addressed along with the high-profile ones. +
++Before banning Trump, Twitter and Facebook announced initiatives that acknowledged their platformsâ significant role in the world and the importance of their moderation decisions. Facebookâs independent oversight board, two years in the making, is now up and running and accepting appeals of Facebookâs content moderation decisions from users. (Who knows? Maybe Trump will submit one.) Twitter CEO Jack Dorsey, in a long thread about Trumpâs ban, which he called a âfailure ... to promote healthy conversation,â pointed to Twitterâs effort called âblueskyâ to develop some kind of âstandardâ for internet conversation that Twitter would follow but which would also âtake many years to develop.â +
++Twitter has also updated its civic integrity policy and temporarily suspended QAnon supporter Rep. Marjorie Taylor Green (R-GA), who frequently tweets election misinformation, for violating it. +
++In an ideal world, Twitter and Facebook wouldnât be left to make these decisions at all. Democratically elected world leaders wouldnât spend the aftermath of their election losses fomenting dissent among their supporters and tacitly approving their violent uprisings, and they wouldnât be enabled by the people and institutions that are supposed to keep them in check. +
++âThe promise that I and others believed in, of Twitter as a tool for world leaders to be closer to their electorates, to have a more direct and tangible relationship with their constituents than ever before â no one has proven that promise more effectively than Donald Trump,â Sharp told Recode. âAnd no one has perverted it to do more harm than Donald Trump.â +
++Facebook and Twitter are in an impossible situation, but itâs one they created for themselves. And they also get to decide what comes next. +
++Open Sourced is made possible by Omidyar Network. All Open Sourced content is editorially independent and produced by our journalists. +
++The full pardon of Anthony Levandowski came out of nowhere. +
++In one of his final acts as President, Donald Trump early on Wednesday morning suddenly pardoned the engineer at the center of an iconic, litigious, and years-long conflict between Uber, Google, and federal prosecutors over the technology for self-driving cars. +
++Encouraged by some of his highest-profile backers in Silicon Valley, such as venture capitalist Peter Thiel, Trump issued the surprise full pardon to Anthony Levandowski, a former Google executive who had decamped to work for Uber. Levandowski was last year sentenced to 18 months in prison after pleading guilty to stealing trade secrets from Google that he then used to help Uber in the self-driving race. +
++The announcement came as a shock for several reasons: One was that the news that Levandowski was seeking a pardon had not previously been reported. Another was that it was yet another twist in a legal saga that went on for years â in addition to the federal conviction, Googleâs self-driving arm, Waymo, at one point sued Uber in a messy legal case before reaching a settlement. Finally, the thinking was, the matter was basically resolved. +
++And the final reason making the news so surprising was the cast of characters that the White House said pushed for Levandowskiâs full pardon. In addition to Thiel â who was once Trumpâs most prominent backer in Silicon Valley â Levandowskiâs supporters in his pardon quest included Palmer Luckey, the founder of the virtual-reality company Oculus and a major Trump campaign donor; Michael Ovitz, the legendary founder of the Hollywood talent giant CAA; and other investors and executives tied to Thiel, such as one of his top aides, Blake Masters. +
++âMr. Levandowski is an American entrepreneur who led Googleâs efforts to create self-driving technology. Mr. Levandowski pled guilty to a single criminal count arising from civil litigation,â the White House said in its statement. âNotably, his sentencing judge called him a âbrilliant, groundbreaking engineer that our country needs.â Mr. Levandowski has paid a significant price for his actions and plans to devote his talents to advance the public good.â +
+Steve Smith's contract not renewed by Rajasthan Royals ahead of IPL-14 - Under Smith's captaincy, the inaugural edition champions finished last in the last IPL in the U.A.E.
Cricket Australia lauds India for epic Test series win; thanks BCCI for sacrifices to make it a success - The CA officials said that the BCCI's cooperation was crucial to making the tour a hit. The series gave the financially struggling CA a major boost with an expected revenue of 300 million Australian dollars
Warne predicts âhuge falloutâ in Australian team after series loss to India - Warne was, however, effusive in his praise for the Indian team which braved injuries to its key players and absence of regular skipper Virat Kohli after the first Test on paternity leave to emerge triumphant
Harbhajan says IPL contract with CSK has ended - Veteran Indian off-spinner Harbhajan Singh on Wednesday said his contract with IPL franchise Chennai Super Kings has ended, bringing to a conclusion h
At 13th spot, Pant is now world's best-ranked keeper in Tests - India's Rishabh Pant became the top-ranked wicket-keeper batsman in the world after his sensational series-winning 89-run knock in the Brisbane matc
Ensure continuous supply of ration to tribal people - HC tells govt. to construct road to facilitate this
Supreme Court rejects pleas seeking review of 2018 Aadhaar verdict - The Aadhaar Bill was certified as a money bill which enabled the government to get it cleared without getting the assent of a majority in Rajya Sabha
Supreme Court directs free education to minor children of rape victim - It has also ordered the Deputy Commissioner of Ranchi to consider the case of the petitioner for a house under Prime Minister Awas Yojna or any other Central or State Scheme.
PIL plea wants voting via EVMs for those on poll duty - âIt will avoid difficulties in casting votes, ensure high polling percentageâ
âEstablish Advocates Training Academy in T.N.â - PIL plea also wants seminars, talks on legal topics organised
Navalny video: Putin palace claims reach millions for jailed critic - The jailed opposition figure alleges the property was paid for "with the largest bribe in history".
Greece #Metoo: Women ending silence of sport abuse shake Greece - The decision by ex-champion Sofia Bekatorou to describe how she was assaulted leads to a #Metoo moment.
Biden inauguration: EU's von der Leyen welcomes 'friend in White House' - European Commission President Ursula von der Leyen says the EU is ready for a new start with the US.
Audi to make electric cars with China's oldest carmaker FAW - FAW counts Red Flag limousines, used by China's communist party leaders, among its products.
Italy PM Conte wins crucial Senate vote to stay in power - But Giuseppe Conte lacks an absolute majority in the Senate and the row over his future continues.
CentOS is goneâbut RHEL is now free for up to 16 production servers - RHEL is now free for dev teams, and it's even free in production for up to 16 systems. - link
Qualcomm repackages last yearâs flagship SoC as the âSnapdragon 870â - Qualcomm recycles the Snapdragon 865+, now with a 3 percent clock boost. - link
Fired former data scientist Rebekah Jones arrested, tests positive for COVID-19 - State accuses her of unauthorized access to its computer systems. - link
Trumpâs Clean Power Plan replacement gets thrown out by a court - Biden administration can start afresh without need to revisit existing EPA rules. - link
Todayâs best tech deals: Lots of Switch games, Fire HD tablets, and more - Dealmaster also has deals on Hitman 3, Roomba vacuums, and the iPad Air. - link
+The French exchange student raised his hand and said, "Excuse me Madam, but I don't know how to say fractions. How do you say those?" +
++"Easy," said the teacher, "you just say the top number and then the bottom number is read as an ordinal number. For example, 2/3 is 'two-thirds', 3/4 is 'three-fourths', and 2/5 is 'two-fifths'." +
++"Thanks, I understand, "said the exchange student. +
++"Good," said the teacher, and then asked the student, "so how do you say 4/8?" +
++"Should I reduce?" asked the boy. +
++"That would be best," said the teacher. +
++"One-second," said the boy. +
++"Take as long as you need," said the teacher. +
+ submitted by /u/AFKOIC
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+Two bored casino dealers were waiting at a craps table. A Very attractive blonde woman arrived and bet twenty thousand Dollars on a single roll of the dice. She said, âI hope you donât Mind, but I feel much luckier when Iâm completely nude.â With that, she stripped from her neck down, rolled the dice And yelled, âMama needs new clothes!â Then she HolleredâŠâYES! YES! I WON! I WON!â She jumped up and Down and hugged each of the dealers. She then picked up all The money and her clothes and quickly departed. The dealers just stared at each other dumbfounded. Finally, One of them asked, âWhat did she roll?â The other answered, âI donât know, I thought YOU were watching! +
+ submitted by /u/TrustedChimp495
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+He was clearly just taking a political stand. +
+ submitted by /u/CIMMGW
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+Me: Can we change the subject? +
++My wife: Ok, more chores around the house need to be done by you. +
+ submitted by /u/porichoygupto
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+This is why people with no sense of humour have a heightened sense of self-importance. +
+ submitted by /u/Mr_1nsomniac
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