diff --git a/15 November, 2020.html b/15 November, 2020.html new file mode 100644 index 0000000..a5ba66d --- /dev/null +++ b/15 November, 2020.html @@ -0,0 +1,232 @@ + +
+ + + ++The global pandemic of the novel coronavirus that started in Wuhan, China has affected more than 2 million people worldwide and caused more than 130,000 tragic deaths. To date, the COVID-19 virus is still spreading and affecting thousands of people. The main problem with testing for COVID-19 is that there are very few test kits available for a large number of affected or suspicious individuals. This leads to the need for automatic detection systems that use artificial intelligence. Deep learning is one of the most powerful AI tools available, so we recommend creating a convolutional neural network to detect COVID-19 positive patients from chest radiographs. According to previous studies, lung X-rays of COVID-19-positive patients show obvious characteristics, so this is a reliable method for testing patients because X-ray examination of suspicious patients is easier than rt-PCR. Our model has been trained with 820 chest radiographic images (excluding data augmentation) collected from 3 databases, with a classification accuracy of 99.61% (training accuracy of 99.59%), the sensitivity of 99.21%, and specificity of 99.29 %, proved that our model has become a reliable COVID-19 detector. +
++The global pandemic of the novel coronavirus that started in Wuhan, China has affected more than 2 million people worldwide and caused more than 130,000 tragic deaths. To date, the COVID-19 virus is still spreading and affecting thousands of people. The main problem with testing for COVID-19 is that there are very few test kits available for a large number of affected or suspicious individuals. This leads to the need for automatic detection systems that use artificial intelligence. Deep learning is one of the most powerful AI tools available, so we recommend creating a convolutional neural network to detect COVID-19 positive patients from chest radiographs. According to previous studies, lung X-rays of COVID-19-positive patients show obvious characteristics, so this is a reliable method for testing patients because X-ray examination of suspicious patients is easier than rt-PCR. Our model has been trained with 820 chest radiographic images (excluding data augmentation) collected from 3 databases, with a classification accuracy of 99.61% (training accuracy of 99.59%), the sensitivity of 99.21%, and specificity of 99.29 %, proved that our model has become a reliable COVID-19 detector. +
++Background Antigen point of care tests (AgPOCT) can accelerate SARS-CoV-2 testing. As first AgPOCT are becoming available, there is a growing interest in their utility and performance. Methods Here we compare AgPOCT products by seven suppliers: the Abbott Panbio COVID-19 Ag Rapid Test; the RapiGEN BIOCREDIT COVID-19 Ag; the Healgen Coronavirus Ag Rapid Test Cassette (Swab); the Coris Bioconcept Covid.19 Ag Respi-Strip; the R-Biopharm RIDA QUICK SARS-CoV-2 Antigen; the NAL von minden NADAL COVID19-Ag Test; and the Roche/SD Biosensor SARS-CoV Rapid Antigen Test. Tests were evaluated on recombinant nucleoprotein, cultured endemic and emerging coronaviruses, stored clinical samples with known SARS-CoV-2 viral loads (n=138), stored samples from patients with respiratory agents other than SARS-CoV-2 (n=100), as well as self-sampled swabs from healthy volunteers (n=35). Findings Limits of detection in six of seven tested products ranged between 2.08 X 106 and 2.88 X 107 copies per swab, the outlier at 1.58 X 1010 copies per swab. Specificities ranged between 98.53% and 100% in five products, with two outliers at 94.85% and 88.24%. False positive results were not associated with any specific respiratory agent. As some of the tested AgPOCT were early production lots, the observed issues with specificity are unlikely to persist. Interpretation The sensitivity range of most AgPOCT overlaps with viral load figures typically observed during the first week of symptoms, which marks the infectious period in the majority patients. AgPOCTs with a limit of detection that approximates the virus concentration above which patients are infectious may enable shortcuts in decision-making in various areas of healthcare and public health. +
++The SARS-CoV-2 reproduction number has become an essential parameter for monitoring disease transmission across settings and guiding interventions. The UK published weekly estimates of the reproduction number in the UK starting in May 2020 which are formed from multiple independent estimates. In this paper, we describe methods used to estimate the time-varying SARS-CoV-2 reproduction number for the UK. We used multiple data sources and estimated a serial interval distribution from published studies. We describe regional variability and how estimates evolved during the early phases of the outbreak, until the relaxing of social distancing measures began to be introduced in early July. Our analysis is able to guide localised control and provides a longitudinal example of applying these methods over long timescales. +
++Objective. The aim of this was to assess the short-term impact of the pandemic on non-COVID-19 patients living in a one-million inhabitants area in Northern Italy (Bologna Metropolitan Area-BMA), analyzing time trends of Emergency Department (ED) visits, hospitalizations and mortality. Methods. We conducted a retrospective observational study using data extracted from BMA healthcare informative systems. Weekly trends of ED visits, hospitalizations, in- and out-of-hospital, all-cause and cause-specific mortality between December 1st, 2019 to May 31st, 2020, were compared with those of the same period of the previous year, using Joinpoint regression models and incidence rate ratios. Results. Non-COVID-19 ED visits and hospitalizations showed a stable trend until the first Italian case of COVID-19 has been recorded, on February 19th, 2020, when they dropped simultaneously. The reduction of ED visits was observed in all age groups and across all severity and diagnosis groups. In the lockdown period a significant increase was found in overall out-of-hospital mortality (43.2%) and cause-specific out-of-hospital mortality related to neoplasms (76.7%), endocrine, nutritional and metabolic (79.5%) as well as cardiovascular (32.7%) diseases. Conclusions. The pandemic caused a sudden drop of ED visits and hospitalizations of non-COVID-19 patients during the lockdown period, and a concurrent increase in out-of-hospital mortality mainly driven by deaths for neoplasms, cardiovascular and endocrine diseases. The findings of this study might be useful to understand both the population reaction and the healthcare system response at the early phases of the pandemic in terms of reduced demand of care and systems capability in intercepting it. +
+A Study Evaluating the Efficacy and Safety of CKD-314 in Hospitalized Adult Patients Diagnosed With COVID-19 Pneumonia - Condition: COVID-19
Intervention: Drug: Nafamostat Mesilate
Sponsor: Chong Kun Dang Pharmaceutical
Not yet recruiting
Phase III Double-blind, Placebo-controlled Study of AZD7442 for Post- Exposure Prophylaxis of COVID-19 in Adults - Condition: COVID-19
Interventions: Drug: AZD7442; Drug: Placebo
Sponsors: AstraZeneca; QuintilesIMS
Not yet recruiting
Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult. - Condition: COVID-19
Interventions: Drug: AZD7442; Drug: Placebo
Sponsors: AstraZeneca; QuintilesIMS
Not yet recruiting
Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia - Condition: Covid19
Intervention: Dietary Supplement: Rhea Health Tone®
Sponsors: Universitas Padjadjaran; PT. Rhea Pharmaceutical Sciences Indonesia; Prodia Diacro Laboratories P.T.
Not yet recruiting
Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection - Condition: Covid19
Interventions: Drug: Clarithromycin 500mg; Drug: Azithromycin; Drug: Placebo
Sponsor: South Valley University
Completed
Intravenous Infusion of CAP-1002 in Patients With COVID-19 - Condition: Covid19
Interventions: Biological: CAP-1002; Biological: Placebo
Sponsor: Capricor Inc.
Recruiting
Hyperimmune Plasma for Patients With COVID-19 - Condition: Covid19
Intervention: Other: treated with hyperimmune plasma
Sponsor: ANNA FALANGA
Recruiting
Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19 - Condition: COVID-19
Interventions: Drug: FSD201; Drug: Placebo
Sponsor: FSD Pharma, Inc.
Not yet recruiting
Mesenchymal Stem Cells in Patients Diagnosed With COVID-19 - Condition: Covid19
Interventions: Biological: MSC; Drug: Control
Sponsors: Hospital Reg. Lic. Adolfo Lopez Mateos; Instituto de Terapia Celular: ITC
Recruiting
Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19 - Condition: COVID-19
Interventions: Biological: COVI-VAC; Other: Placebo
Sponsor: Codagenix, Inc
Not yet recruiting
Efficacy of Probiotics in Reducing Duration and Symptoms of COVID-19 (PROVID-19) - Condition: COVID-19
Interventions: Dietary Supplement: Probiotics (2 strains 10x10^9 UFC); Dietary Supplement: Placebo (potato starch and magnesium stearate)
Sponsors: Centre de recherche du Centre hospitalier universitaire de Sherbrooke; Lallemand Health Solutions
Not yet recruiting
Prevention With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19) (TS-COVID) - Condition: Covid19
Intervention: Drug: Chloroquine
Sponsor: Fundacion Clinica Valle del Lili
Active, not recruiting
Randomised Study of Plasma Exchange in Severe COVID-19 - Condition: COVID19
Intervention: Drug: OCTAPLAS
Sponsor: University College, London
Recruiting
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Respiratory Distress - Condition: Covid19
Intervention: Device: Hyperbaric Oxygen Therapy (HBOT)
Sponsor: NYU Langone Health
Not yet recruiting
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs - Condition: COVID-19
Intervention: Other: Rehabilitation-focused program
Sponsor: VA Office of Research and Development
Not yet recruiting
Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor - The continued spread of 2019-nCoV has prompted widespread concern around the world. WHO formally named COVID-19 and International Committee on Taxonomy called it Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Due to this viral attack, the whole world is in lockdown. Presently, there is no effective way to control it, except social distancing and hygienic activity. World class scientists and researchers are trying to make vaccine and discover the medicine against the control and…
Peptide modelling and screening against human ACE2 and spike glycoprotein RBD of SARS-CoV-2 - Outbreak of Coronavirus Disease 2019 (COVID-19) has become a great challenge for scientific community globally. Virus enters cell through spike glycoprotein fusion with ACE2 (Angiotensin-Converting Enzyme 2) human receptor. Hence, spike glycoprotein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a potential target for diagnostics, vaccines, and antibodies. Also, virus entry can be prevented by blocking ACE2 thus, ACE2 can be considered potential target for therapeutics. As…
Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility - Covid-19 (SARS CoV-2) has become a deadly, world-wide pandemic. Although most who are infected survive, complications from the virus can be pronounced and long-lasting. To date, of all the respiratory viruses including influenza and coronaviruses, only influenza has had a drug (i.e., Tamiflu) specifically targeted to treat and prevent infection. As a result, additional agents that specifically target viral production and are clinically feasible are needed to alleviate respiratory viral…
Identification of a repurposed drug as an inhibitor of Spike protein of human coronavirus SARS-CoV-2 by computational methods - Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is an emerging new viral pathogen that causes severe respiratory disease. SARS-CoV-2 is responsible for the outbreak of COVID-19 pandemic worldwide. As there are no confirmed antiviral drugs or vaccines currently available for the treatment of COVID-19, discovering potent inhibitors or vaccines are urgently required for the benefit of humanity. The glycosylated Spike protein (S-protein) directly interacts with human…
The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses - The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals. We present work that the mammalian SKI complex is a broad-spectrum, host-directed, antiviral drug target. Yeast suppressor screening was utilized to find a functional genetic interaction between proteins from influenza A virus (IAV) and Middle East respiratory syndrome coronavirus (MERS-CoV) with eukaryotic proteins that may be potential host factors involved in replication. This screening identified the SKI…
Recent Advances in Discovery of Potent Proteases Inhibitors Targeting the SARS Coronaviruses - Across the globe, countries are being challenged by the SARS-CoV-2 (COVID-19) pandemic in ways they have never been before. Global outbreak of SARS-CoV-2 with an uncertain fatality rate has imposed extreme challenges on global health. The World Health Organization (WHO) has officially declared the outbreak of COVID-19 a pandemic, after the disease caused by the new coronavirus spread to more than 100 countries. To date, various therapeutic approaches has been proposed and are being implemented…
High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2 - Arenaviruses are a large family of enveloped negative-strand RNA viruses that include several causative agents of severe hemorrhagic fevers. Currently, there are no FDA-licensed drugs to treat arenavirus infection except for the off-labeled use of ribavirin. Here, we performed antiviral drug screening against the Old World arenavirus lymphocytic choriomeningitis virus (LCMV) using an FDA-approved drug library. Five drug candidates were identified, including mycophenolic acid, benidipine…
Necrostatin-1 and necroptosis inhibition: pathophysiology and therapeutic implications - Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in various diseases, including inflammatory diseases, cardiovascular diseases and neurological diseases. However, the potential of Nec-1 in diseases has not received much attention. Nec-1 is able to inhibit necroptosis signaling pathway and thus ameliorate necroptotic cell…
Russelioside B; A Pregnane Glycoside for Treatment of Gastric Ulcer via Modulation of Heat Shock Protein-70 and Vascular Endothelial Growth Factor - Gastric ulcers are a very common public health problem affecting up to 10% worldwide. Russelioside B is a steroidal glycoside isolated from several Caralluma species. No study tested the ulcer healing potential of the compound. The current study aimed to assess the protective effect of russelioside B against ethanol-induced gastric mucosal injury in rats. Ulcer was induced on rats by a single intragastric dose of absolute ethanol (5 mL/kg). Rats were randomly assorted into four groups (n=8) and…
In silico analysis of selected alkaloids against main protease (M(pro)) of COVID-19 - In the present situation, COVID-19 has become the global health concern due to its high contagious nature. It initially appeared in December 2019 in Wuhan, China and now affected more than 190 countries. As of now preventive measures are the sole solution to stop this disease for further transmission from person to person transmissions as there is no effective treatment or vaccine available to date. Research and development of new molecule is a laborious process; therefore, drug repurposing can…
Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity - Angiotensin-converting enzyme 2 (ACE2) is a host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inhibiting the interaction between the envelope spike glycoproteins (S-proteins) of SARS-CoV-2 and ACE2 is a potential antiviral therapeutic approach, but little is known about how dietary compounds interact with ACE2. The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3’,4’-hydroxylation inhibit recombinant human (rh)ACE2 activity….
Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target - Rapid accumulation of viral proteins in host cells render viruses highly dependent on cellular chaperones including heat shock protein 90 (Hsp90). Three highly pathogenic human coronaviruses, including MERS-CoV, SARS-CoV and SARS-CoV-2, have emerged in the past 2 decades. However, there is no approved antiviral agent against these coronaviruses. We inspected the role of Hsp90 for coronavirus propagation. First, an Hsp90 inhibitor, 17-AAG, significantly suppressed MERS-CoV propagation in cell…
COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management - At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective…
Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection - No abstract
Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as M(Pro) inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) - OBJECTIVES: The aim of this study was to use Ligand-based pharmacophore modelling approach for four established antiviral drugs, namely remdesivir, lopinavir, ritonavir and hydroxychloroquine for COVID-19 inhibitors as training sets. In this study Twenty vanillin derivatives together with monolaurin and tetrodotoxin were used as test sets to evaluate as potential SARS-CoV-2 inhibitors. The Structure-based pharmacophore modelling approach was also performed using 5RE6, 5REX and 5RFZ in order to…
AN EFFICIENT METHODOLOGY TO MANAGE THE ADMISSIONS IN HOSPITALS DURING THE PANDEMICS SUCH AS COVID 19 -
SARS-CoV-2 예방을 위한 mRNA기반 항원보강제 혼합물 합성 방법 - 본 발명은 SARS-CoV-2(코로나 바이러스) 예방을 위한 mRNA 항원보강제에 관한 것으로 코로나 바이러스에 대한 백신으로서 상기의 항원에 대한 예방을 목적으로 하고 있다. 아이디어에는 보강제에 해당하는 완전프로인트항원보강제(CFA)와 불완전프로인트항원보강제(IFA), 번역과 안정성의 최적화가 된 mRNA, mRNA 운반체, 양이온성 지질 나노입자(lipid nanoparticles)로 구성되며 기존의 백신에 비해 효율성과 안정성의 측면에서 더 향상된 효과를 가지고 있다.
Methods for treating Arenaviridae and Coronaviridae virus infections - Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I:
wherein the ’ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
++Atemschutz-Baukastensystem, das aufweist:
+Vorrichtung zur Übergabe von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen nach einer Dekontamination, umfassend eine Einrichtung zur Dekontamination der mit Krankheitserregern kontaminierten Gegenstände oder Erzeugnisse mit mindestens einer UV-Strahlungsquelle (24), eine Durchzugseinrichtung mit Ein- und/oder Ausgabebereichen für die kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse, dadurch gekennzeichnet, dass die Durchzugseinrichtung im Eingang bzw. im Ausgang zum Ein- und/oder Ausgabebereich angeordnete sich paarweise gegenüberliegende Walzen (17) und Räder (4) umfasst, die zum Einzug bzw. zur Ausgabe der kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse vorgesehen sind, wobei die Walzen (17) und die Räder (4) durch im Ein- und/oder Ausgabebereich angeordnete Sensoren (23) und einer elektronische Kontrolleinheit (27) in Bewegung bringbar sind, wobei die Gegenstände oder Erzeugnisse in den Bereich der Einrichtung zur Dekontamination förderbar sind, der zwischen den paarweise angeordneten Walzen (17) und Rädern (4) vorgesehen ist, welcher sich gegenüberliegende Platten (25) aus Quarzglas oder einem UV-transparenten Polymermaterial, wie Graphen oder Kunstglas umfasst, über bzw. unter welchen die UV-Strahlungsquelle (24) angeordnet ist, welche als UVC-LED-Leiste und/oder Modul mit mindestens einer LED-Lampe ausgebildet ist.
제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. [화학식 1] .
+ JPEG
+ 112020094463686-pat00017.jpg
+ 48
+ 135
新型冠状病毒中和性抗体滴度检测ELISA试剂盒 - 本发明提供一种新型冠状病毒中和性抗体滴度检测ELISA试剂盒,其中包括:包被有生物素‑链霉亲和素标记的人ACE2蛋白的酶标板、辣根过氧化酶标记的新型冠状病毒RBD蛋白、新型冠状病毒中和性抗体阳性对照、包被液、洗涤液、稀释液、封闭液、显色液和终止液等。该试剂盒具有成本低,操作简单,高灵敏度、高特异性、高准确度的特点,可用于新型冠状病毒中和抗体的批量、快速检测。
Zahnbürstenaufsatz, elektrische Versorgungseinheit einer elektrischen Zahnbürste, elektrische Zahnbürste mit einem Zahnbürstenaufsatz, Zahnbürste sowie Testaufsatz für eine elektrische Zahnbürste -
++
Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.
+Hygiene-Mundstückelement (100), aufweisend einen ersten Endabschnitt (103), welcher ausgebildet ist zur Verbindung mit einem Griff-Mundstückelement (200) einer Wasserpfeife (400) und aufweisend einen zweiten Endabschnitt (104), welcher als mundseitiges, freies Ende ausgebildet ist, wobei das Hygiene-Mundstückelement (100) ein erstes Filterelement (101) aufweist, wobei das erste Filterelement (101) wenigstens ein adsorbierendes Material umfasst und/oder wobei das Hygiene-Mundstückelement (100) ein zweites Filterelement (102) aufweist, wobei das zweite Filterelement (102) Metalloxid und/oder elektrostatisch geladene Fasern umfasst.
The global pandemic of the novel coronavirus that started in Wuhan, China has affected more than 2 million people worldwide and caused more than 130,000 tragic deaths. To date, the COVID-19 virus is still spreading and affecting thousands of people. The main problem with testing for COVID-19 is that there are very few test kits available for a large number of affected or suspicious individuals. This leads to the need for automatic detection systems that use artificial intelligence. Deep learning is one of the most powerful AI tools available, so we recommend creating a convolutional neural network to detect COVID-19 positive patients from chest radiographs. According to previous studies, lung X-rays of COVID-19-positive patients show obvious characteristics, so this is a reliable method for testing patients because X-ray examination of suspicious patients is easier than rt-PCR. Our model has been trained with 820 chest radiographic images (excluding data augmentation) collected from 3 databases, with a classification accuracy of 99.61% (training accuracy of 99.59%), the sensitivity of 99.21%, and specificity of 99.29 %, proved that our model has become a reliable COVID-19 detector.
The global pandemic of the novel coronavirus that started in Wuhan, China has affected more than 2 million people worldwide and caused more than 130,000 tragic deaths. To date, the COVID-19 virus is still spreading and affecting thousands of people. The main problem with testing for COVID-19 is that there are very few test kits available for a large number of affected or suspicious individuals. This leads to the need for automatic detection systems that use artificial intelligence. Deep learning is one of the most powerful AI tools available, so we recommend creating a convolutional neural network to detect COVID-19 positive patients from chest radiographs. According to previous studies, lung X-rays of COVID-19-positive patients show obvious characteristics, so this is a reliable method for testing patients because X-ray examination of suspicious patients is easier than rt-PCR. Our model has been trained with 820 chest radiographic images (excluding data augmentation) collected from 3 databases, with a classification accuracy of 99.61% (training accuracy of 99.59%), the sensitivity of 99.21%, and specificity of 99.29 %, proved that our model has become a reliable COVID-19 detector.
Background Antigen point of care tests (AgPOCT) can accelerate SARS-CoV-2 testing. As first AgPOCT are becoming available, there is a growing interest in their utility and performance. Methods Here we compare AgPOCT products by seven suppliers: the Abbott Panbio COVID-19 Ag Rapid Test; the RapiGEN BIOCREDIT COVID-19 Ag; the Healgen Coronavirus Ag Rapid Test Cassette (Swab); the Coris Bioconcept Covid.19 Ag Respi-Strip; the R-Biopharm RIDA QUICK SARS-CoV-2 Antigen; the NAL von minden NADAL COVID19-Ag Test; and the Roche/SD Biosensor SARS-CoV Rapid Antigen Test. Tests were evaluated on recombinant nucleoprotein, cultured endemic and emerging coronaviruses, stored clinical samples with known SARS-CoV-2 viral loads (n=138), stored samples from patients with respiratory agents other than SARS-CoV-2 (n=100), as well as self-sampled swabs from healthy volunteers (n=35). Findings Limits of detection in six of seven tested products ranged between 2.08 X 106 and 2.88 X 107 copies per swab, the outlier at 1.58 X 1010 copies per swab. Specificities ranged between 98.53% and 100% in five products, with two outliers at 94.85% and 88.24%. False positive results were not associated with any specific respiratory agent. As some of the tested AgPOCT were early production lots, the observed issues with specificity are unlikely to persist. Interpretation The sensitivity range of most AgPOCT overlaps with viral load figures typically observed during the first week of symptoms, which marks the infectious period in the majority patients. AgPOCTs with a limit of detection that approximates the virus concentration above which patients are infectious may enable shortcuts in decision-making in various areas of healthcare and public health.
The SARS-CoV-2 reproduction number has become an essential parameter for monitoring disease transmission across settings and guiding interventions. The UK published weekly estimates of the reproduction number in the UK starting in May 2020 which are formed from multiple independent estimates. In this paper, we describe methods used to estimate the time-varying SARS-CoV-2 reproduction number for the UK. We used multiple data sources and estimated a serial interval distribution from published studies. We describe regional variability and how estimates evolved during the early phases of the outbreak, until the relaxing of social distancing measures began to be introduced in early July. Our analysis is able to guide localised control and provides a longitudinal example of applying these methods over long timescales.
Objective. The aim of this was to assess the short-term impact of the pandemic on non-COVID-19 patients living in a one-million inhabitants area in Northern Italy (Bologna Metropolitan Area-BMA), analyzing time trends of Emergency Department (ED) visits, hospitalizations and mortality. Methods. We conducted a retrospective observational study using data extracted from BMA healthcare informative systems. Weekly trends of ED visits, hospitalizations, in- and out-of-hospital, all-cause and cause-specific mortality between December 1st, 2019 to May 31st, 2020, were compared with those of the same period of the previous year, using Joinpoint regression models and incidence rate ratios. Results. Non-COVID-19 ED visits and hospitalizations showed a stable trend until the first Italian case of COVID-19 has been recorded, on February 19th, 2020, when they dropped simultaneously. The reduction of ED visits was observed in all age groups and across all severity and diagnosis groups. In the lockdown period a significant increase was found in overall out-of-hospital mortality (43.2%) and cause-specific out-of-hospital mortality related to neoplasms (76.7%), endocrine, nutritional and metabolic (79.5%) as well as cardiovascular (32.7%) diseases. Conclusions. The pandemic caused a sudden drop of ED visits and hospitalizations of non-COVID-19 patients during the lockdown period, and a concurrent increase in out-of-hospital mortality mainly driven by deaths for neoplasms, cardiovascular and endocrine diseases. The findings of this study might be useful to understand both the population reaction and the healthcare system response at the early phases of the pandemic in terms of reduced demand of care and systems capability in intercepting it.
Atemschutz-Baukastensystem, das aufweist: +- eine auf zumindest Mund und Nase einer Person aufsetzbare Maske (1), die einen Eingang (11) und einen Ausgang (12) aufweist, und +- mindestens einen Schlauch (3, 31, 32), +- wobei sämtliche Komponenten des Atemschutz-Baukastensystems modular ausgebildet und über Steckverbindungen oder Schraubverbindungen (115, 125, 155, 165, 175, 215, 315, 75, 915) miteinander verbindbar sind, um der Maske (1) Luft über deren Eingang (11) zuzuführen und/oder ausgeatmete Luft vom Ausgang (12) der Maske (1) wegzuführen. + + +
+ +* **Vorrichtung zur Übergabe und Dekontamination von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen** -Vorrichtung zur Übergabe von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen nach einer Dekontamination, umfassend eine Einrichtung zur Dekontamination der mit Krankheitserregern kontaminierten Gegenstände oder Erzeugnisse mit mindestens einer UV-Strahlungsquelle (24), eine Durchzugseinrichtung mit Ein- und/oder Ausgabebereichen für die kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse, dadurch gekennzeichnet, dass die Durchzugseinrichtung im Eingang bzw. im Ausgang zum Ein- und/oder Ausgabebereich angeordnete sich paarweise gegenüberliegende Walzen (17) und Räder (4) umfasst, die zum Einzug bzw. zur Ausgabe der kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse vorgesehen sind, wobei die Walzen (17) und die Räder (4) durch im Ein- und/oder Ausgabebereich angeordnete Sensoren (23) und einer elektronische Kontrolleinheit (27) in Bewegung bringbar sind, wobei die Gegenstände oder Erzeugnisse in den Bereich der Einrichtung zur Dekontamination förderbar sind, der zwischen den paarweise angeordneten Walzen (17) und Rädern (4) vorgesehen ist, welcher sich gegenüberliegende Platten (25) aus Quarzglas oder einem UV-transparenten Polymermaterial, wie Graphen oder Kunstglas umfasst, über bzw. unter welchen die UV-Strahlungsquelle (24) angeordnet ist, welche als UVC-LED-Leiste und/oder Modul mit mindestens einer LED-Lampe ausgebildet ist. + + +
+ +* **제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물** - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. +[화학식 1] +. + + JPEG + 112020094463686-pat00017.jpg + 48 + 135 + +* **新型冠状病毒中和性抗体滴度检测ELISA试剂盒** - 本发明提供一种新型冠状病毒中和性抗体滴度检测ELISA试剂盒,其中包括:包被有生物素‑链霉亲和素标记的人ACE2蛋白的酶标板、辣根过氧化酶标记的新型冠状病毒RBD蛋白、新型冠状病毒中和性抗体阳性对照、包被液、洗涤液、稀释液、封闭液、显色液和终止液等。该试剂盒具有成本低,操作简单,高灵敏度、高特异性、高准确度的特点,可用于新型冠状病毒中和抗体的批量、快速检测。 + +* **Zahnbürstenaufsatz, elektrische Versorgungseinheit einer elektrischen Zahnbürste, elektrische Zahnbürste mit einem Zahnbürstenaufsatz, Zahnbürste sowie Testaufsatz für eine elektrische Zahnbürste** -Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen. + + +
+ +* **Wasserpfeife mit Hygienefunktion** -Hygiene-Mundstückelement (100), aufweisend einen ersten Endabschnitt (103), welcher ausgebildet ist zur Verbindung mit einem Griff-Mundstückelement (200) einer Wasserpfeife (400) und aufweisend einen zweiten Endabschnitt (104), welcher als mundseitiges, freies Ende ausgebildet ist, wobei das Hygiene-Mundstückelement (100) ein erstes Filterelement (101) aufweist, wobei das erste Filterelement (101) wenigstens ein adsorbierendes Material umfasst und/oder wobei das Hygiene-Mundstückelement (100) ein zweites Filterelement (102) aufweist, wobei das zweite Filterelement (102) Metalloxid und/oder elektrostatisch geladene Fasern umfasst. + + +
+ +* **알츠하이머병 혹은 뇌졸중의 뉴로인플라마섬의 치료제로서 디디에스 혹은 그 유도체** - 목표 / 배경 :이 연구는 신경-정신과 증상을 측면과 구별하기 위해 2018 'NIA-AA 연구 프레임 워크'에 따라 뉴로인플라마섬 경쟁자로서 4, 4'- 디아미노디 페닐설폰(DDS, 디디에스)으로 치료받은 알츠하이머병(AD) 환자를 조사했습니다. 방법 : 서울 연구에서는 AD 진단 기준에 따라 2005 년 1 월부터 2020 년 6 월까지 보관된 소록도 국립병원 EDI 데이터베이스의 AD와 항AD약물(AAD)의 효과를 분석하여 ICD-9와 10 개의 코드를 이용하여 검색 하였습니다. 새로운 바이오마커 (D)를 사용하여 AAD로 인한 AD 증상과 신경정신병적 증상을 관리하여 수치 임상 병기를 분류했습니다. 우리는 서울 연구에서 뉴로인플라마섬 경쟁자로서 뇌경색 및 DDS 관련 사례를 보고합니다. 결과 : DDS는 DDS를 처방했거나 처방하지 않은 사람들과 AD의 비율을 비교할 때 뉴로인플라마섬 경쟁자였습니다. (D)를 도입함으로써, AD의 진행은 NCS 병기 결정을 통해 모니터링 하였습니다. AAD 또는 신경병리 증상을 구별하고 DDS로 치료했습니다. AD는 AAD에 의해 악화될 수 있고 DDS에 의해 경미한 인지 장애로 회복될 수 있습니다. 우리는 서울 연구에서 뇌경색이 발생하기 전과 후에 뉴로인플라마섬 경쟁자로서 DDS가 어떤 역할을 하는지를 임상적으로 확인했습니다. 결론 : DDS는 RBS 분할에 의한 정규/비정규적 우비퀴틴화, NLRP3 inflammasome 형성, Higgins의 캐스케이드 및 철이 풍부한 강자성 나노 입자를 차단하는 역할을 합니다. 바이오마커 (D)를 통하여 DDS로 AD를 예방하고 치료할 수 있습니다. AD에 대한 예방 및 치료 방법으로 뉴로인플라마섬을 치료하는 것을 수치 임상 병기(NCS, Numeric clinical staging)를 통하여 증명하고 있습니다. + + + diff --git a/archive-covid-19/15 November, 2020.html b/archive-covid-19/15 November, 2020.html new file mode 100644 index 0000000..a5ba66d --- /dev/null +++ b/archive-covid-19/15 November, 2020.html @@ -0,0 +1,232 @@ + + + + + ++The global pandemic of the novel coronavirus that started in Wuhan, China has affected more than 2 million people worldwide and caused more than 130,000 tragic deaths. To date, the COVID-19 virus is still spreading and affecting thousands of people. The main problem with testing for COVID-19 is that there are very few test kits available for a large number of affected or suspicious individuals. This leads to the need for automatic detection systems that use artificial intelligence. Deep learning is one of the most powerful AI tools available, so we recommend creating a convolutional neural network to detect COVID-19 positive patients from chest radiographs. According to previous studies, lung X-rays of COVID-19-positive patients show obvious characteristics, so this is a reliable method for testing patients because X-ray examination of suspicious patients is easier than rt-PCR. Our model has been trained with 820 chest radiographic images (excluding data augmentation) collected from 3 databases, with a classification accuracy of 99.61% (training accuracy of 99.59%), the sensitivity of 99.21%, and specificity of 99.29 %, proved that our model has become a reliable COVID-19 detector. +
++The global pandemic of the novel coronavirus that started in Wuhan, China has affected more than 2 million people worldwide and caused more than 130,000 tragic deaths. To date, the COVID-19 virus is still spreading and affecting thousands of people. The main problem with testing for COVID-19 is that there are very few test kits available for a large number of affected or suspicious individuals. This leads to the need for automatic detection systems that use artificial intelligence. Deep learning is one of the most powerful AI tools available, so we recommend creating a convolutional neural network to detect COVID-19 positive patients from chest radiographs. According to previous studies, lung X-rays of COVID-19-positive patients show obvious characteristics, so this is a reliable method for testing patients because X-ray examination of suspicious patients is easier than rt-PCR. Our model has been trained with 820 chest radiographic images (excluding data augmentation) collected from 3 databases, with a classification accuracy of 99.61% (training accuracy of 99.59%), the sensitivity of 99.21%, and specificity of 99.29 %, proved that our model has become a reliable COVID-19 detector. +
++Background Antigen point of care tests (AgPOCT) can accelerate SARS-CoV-2 testing. As first AgPOCT are becoming available, there is a growing interest in their utility and performance. Methods Here we compare AgPOCT products by seven suppliers: the Abbott Panbio COVID-19 Ag Rapid Test; the RapiGEN BIOCREDIT COVID-19 Ag; the Healgen Coronavirus Ag Rapid Test Cassette (Swab); the Coris Bioconcept Covid.19 Ag Respi-Strip; the R-Biopharm RIDA QUICK SARS-CoV-2 Antigen; the NAL von minden NADAL COVID19-Ag Test; and the Roche/SD Biosensor SARS-CoV Rapid Antigen Test. Tests were evaluated on recombinant nucleoprotein, cultured endemic and emerging coronaviruses, stored clinical samples with known SARS-CoV-2 viral loads (n=138), stored samples from patients with respiratory agents other than SARS-CoV-2 (n=100), as well as self-sampled swabs from healthy volunteers (n=35). Findings Limits of detection in six of seven tested products ranged between 2.08 X 106 and 2.88 X 107 copies per swab, the outlier at 1.58 X 1010 copies per swab. Specificities ranged between 98.53% and 100% in five products, with two outliers at 94.85% and 88.24%. False positive results were not associated with any specific respiratory agent. As some of the tested AgPOCT were early production lots, the observed issues with specificity are unlikely to persist. Interpretation The sensitivity range of most AgPOCT overlaps with viral load figures typically observed during the first week of symptoms, which marks the infectious period in the majority patients. AgPOCTs with a limit of detection that approximates the virus concentration above which patients are infectious may enable shortcuts in decision-making in various areas of healthcare and public health. +
++The SARS-CoV-2 reproduction number has become an essential parameter for monitoring disease transmission across settings and guiding interventions. The UK published weekly estimates of the reproduction number in the UK starting in May 2020 which are formed from multiple independent estimates. In this paper, we describe methods used to estimate the time-varying SARS-CoV-2 reproduction number for the UK. We used multiple data sources and estimated a serial interval distribution from published studies. We describe regional variability and how estimates evolved during the early phases of the outbreak, until the relaxing of social distancing measures began to be introduced in early July. Our analysis is able to guide localised control and provides a longitudinal example of applying these methods over long timescales. +
++Objective. The aim of this was to assess the short-term impact of the pandemic on non-COVID-19 patients living in a one-million inhabitants area in Northern Italy (Bologna Metropolitan Area-BMA), analyzing time trends of Emergency Department (ED) visits, hospitalizations and mortality. Methods. We conducted a retrospective observational study using data extracted from BMA healthcare informative systems. Weekly trends of ED visits, hospitalizations, in- and out-of-hospital, all-cause and cause-specific mortality between December 1st, 2019 to May 31st, 2020, were compared with those of the same period of the previous year, using Joinpoint regression models and incidence rate ratios. Results. Non-COVID-19 ED visits and hospitalizations showed a stable trend until the first Italian case of COVID-19 has been recorded, on February 19th, 2020, when they dropped simultaneously. The reduction of ED visits was observed in all age groups and across all severity and diagnosis groups. In the lockdown period a significant increase was found in overall out-of-hospital mortality (43.2%) and cause-specific out-of-hospital mortality related to neoplasms (76.7%), endocrine, nutritional and metabolic (79.5%) as well as cardiovascular (32.7%) diseases. Conclusions. The pandemic caused a sudden drop of ED visits and hospitalizations of non-COVID-19 patients during the lockdown period, and a concurrent increase in out-of-hospital mortality mainly driven by deaths for neoplasms, cardiovascular and endocrine diseases. The findings of this study might be useful to understand both the population reaction and the healthcare system response at the early phases of the pandemic in terms of reduced demand of care and systems capability in intercepting it. +
+A Study Evaluating the Efficacy and Safety of CKD-314 in Hospitalized Adult Patients Diagnosed With COVID-19 Pneumonia - Condition: COVID-19
Intervention: Drug: Nafamostat Mesilate
Sponsor: Chong Kun Dang Pharmaceutical
Not yet recruiting
Phase III Double-blind, Placebo-controlled Study of AZD7442 for Post- Exposure Prophylaxis of COVID-19 in Adults - Condition: COVID-19
Interventions: Drug: AZD7442; Drug: Placebo
Sponsors: AstraZeneca; QuintilesIMS
Not yet recruiting
Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult. - Condition: COVID-19
Interventions: Drug: AZD7442; Drug: Placebo
Sponsors: AstraZeneca; QuintilesIMS
Not yet recruiting
Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia - Condition: Covid19
Intervention: Dietary Supplement: Rhea Health Tone®
Sponsors: Universitas Padjadjaran; PT. Rhea Pharmaceutical Sciences Indonesia; Prodia Diacro Laboratories P.T.
Not yet recruiting
Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection - Condition: Covid19
Interventions: Drug: Clarithromycin 500mg; Drug: Azithromycin; Drug: Placebo
Sponsor: South Valley University
Completed
Intravenous Infusion of CAP-1002 in Patients With COVID-19 - Condition: Covid19
Interventions: Biological: CAP-1002; Biological: Placebo
Sponsor: Capricor Inc.
Recruiting
Hyperimmune Plasma for Patients With COVID-19 - Condition: Covid19
Intervention: Other: treated with hyperimmune plasma
Sponsor: ANNA FALANGA
Recruiting
Ultramicronized Palmitoylethanolamide (PEA) Treatment in Hospitalized Participants With COVID-19 - Condition: COVID-19
Interventions: Drug: FSD201; Drug: Placebo
Sponsor: FSD Pharma, Inc.
Not yet recruiting
Mesenchymal Stem Cells in Patients Diagnosed With COVID-19 - Condition: Covid19
Interventions: Biological: MSC; Drug: Control
Sponsors: Hospital Reg. Lic. Adolfo Lopez Mateos; Instituto de Terapia Celular: ITC
Recruiting
Safety and Immunogenicity of COVI-VAC, a Live Attenuated Vaccine Against COVID-19 - Condition: COVID-19
Interventions: Biological: COVI-VAC; Other: Placebo
Sponsor: Codagenix, Inc
Not yet recruiting
Efficacy of Probiotics in Reducing Duration and Symptoms of COVID-19 (PROVID-19) - Condition: COVID-19
Interventions: Dietary Supplement: Probiotics (2 strains 10x10^9 UFC); Dietary Supplement: Placebo (potato starch and magnesium stearate)
Sponsors: Centre de recherche du Centre hospitalier universitaire de Sherbrooke; Lallemand Health Solutions
Not yet recruiting
Prevention With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19) (TS-COVID) - Condition: Covid19
Intervention: Drug: Chloroquine
Sponsor: Fundacion Clinica Valle del Lili
Active, not recruiting
Randomised Study of Plasma Exchange in Severe COVID-19 - Condition: COVID19
Intervention: Drug: OCTAPLAS
Sponsor: University College, London
Recruiting
Hyperbaric Oxygen for COVID-19 Patients With Moderate to Severe Respiratory Distress - Condition: Covid19
Intervention: Device: Hyperbaric Oxygen Therapy (HBOT)
Sponsor: NYU Langone Health
Not yet recruiting
Chronic Lung Disease and COVID-19: Understanding Severity, Recovery and Rehabilitation Needs - Condition: COVID-19
Intervention: Other: Rehabilitation-focused program
Sponsor: VA Office of Research and Development
Not yet recruiting
Therapeutic Approach against 2019-nCoV by Inhibition of ACE-2 Receptor - The continued spread of 2019-nCoV has prompted widespread concern around the world. WHO formally named COVID-19 and International Committee on Taxonomy called it Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Due to this viral attack, the whole world is in lockdown. Presently, there is no effective way to control it, except social distancing and hygienic activity. World class scientists and researchers are trying to make vaccine and discover the medicine against the control and…
Peptide modelling and screening against human ACE2 and spike glycoprotein RBD of SARS-CoV-2 - Outbreak of Coronavirus Disease 2019 (COVID-19) has become a great challenge for scientific community globally. Virus enters cell through spike glycoprotein fusion with ACE2 (Angiotensin-Converting Enzyme 2) human receptor. Hence, spike glycoprotein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a potential target for diagnostics, vaccines, and antibodies. Also, virus entry can be prevented by blocking ACE2 thus, ACE2 can be considered potential target for therapeutics. As…
Molecular targeting of vulnerable RNA sequences in SARS CoV-2: identifying clinical feasibility - Covid-19 (SARS CoV-2) has become a deadly, world-wide pandemic. Although most who are infected survive, complications from the virus can be pronounced and long-lasting. To date, of all the respiratory viruses including influenza and coronaviruses, only influenza has had a drug (i.e., Tamiflu) specifically targeted to treat and prevent infection. As a result, additional agents that specifically target viral production and are clinically feasible are needed to alleviate respiratory viral…
Identification of a repurposed drug as an inhibitor of Spike protein of human coronavirus SARS-CoV-2 by computational methods - Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is an emerging new viral pathogen that causes severe respiratory disease. SARS-CoV-2 is responsible for the outbreak of COVID-19 pandemic worldwide. As there are no confirmed antiviral drugs or vaccines currently available for the treatment of COVID-19, discovering potent inhibitors or vaccines are urgently required for the benefit of humanity. The glycosylated Spike protein (S-protein) directly interacts with human…
The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses - The SARS-CoV-2 pandemic has made it clear that we have a desperate need for antivirals. We present work that the mammalian SKI complex is a broad-spectrum, host-directed, antiviral drug target. Yeast suppressor screening was utilized to find a functional genetic interaction between proteins from influenza A virus (IAV) and Middle East respiratory syndrome coronavirus (MERS-CoV) with eukaryotic proteins that may be potential host factors involved in replication. This screening identified the SKI…
Recent Advances in Discovery of Potent Proteases Inhibitors Targeting the SARS Coronaviruses - Across the globe, countries are being challenged by the SARS-CoV-2 (COVID-19) pandemic in ways they have never been before. Global outbreak of SARS-CoV-2 with an uncertain fatality rate has imposed extreme challenges on global health. The World Health Organization (WHO) has officially declared the outbreak of COVID-19 a pandemic, after the disease caused by the new coronavirus spread to more than 100 countries. To date, various therapeutic approaches has been proposed and are being implemented…
High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2 - Arenaviruses are a large family of enveloped negative-strand RNA viruses that include several causative agents of severe hemorrhagic fevers. Currently, there are no FDA-licensed drugs to treat arenavirus infection except for the off-labeled use of ribavirin. Here, we performed antiviral drug screening against the Old World arenavirus lymphocytic choriomeningitis virus (LCMV) using an FDA-approved drug library. Five drug candidates were identified, including mycophenolic acid, benidipine…
Necrostatin-1 and necroptosis inhibition: pathophysiology and therapeutic implications - Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in various diseases, including inflammatory diseases, cardiovascular diseases and neurological diseases. However, the potential of Nec-1 in diseases has not received much attention. Nec-1 is able to inhibit necroptosis signaling pathway and thus ameliorate necroptotic cell…
Russelioside B; A Pregnane Glycoside for Treatment of Gastric Ulcer via Modulation of Heat Shock Protein-70 and Vascular Endothelial Growth Factor - Gastric ulcers are a very common public health problem affecting up to 10% worldwide. Russelioside B is a steroidal glycoside isolated from several Caralluma species. No study tested the ulcer healing potential of the compound. The current study aimed to assess the protective effect of russelioside B against ethanol-induced gastric mucosal injury in rats. Ulcer was induced on rats by a single intragastric dose of absolute ethanol (5 mL/kg). Rats were randomly assorted into four groups (n=8) and…
In silico analysis of selected alkaloids against main protease (M(pro)) of COVID-19 - In the present situation, COVID-19 has become the global health concern due to its high contagious nature. It initially appeared in December 2019 in Wuhan, China and now affected more than 190 countries. As of now preventive measures are the sole solution to stop this disease for further transmission from person to person transmissions as there is no effective treatment or vaccine available to date. Research and development of new molecule is a laborious process; therefore, drug repurposing can…
Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity - Angiotensin-converting enzyme 2 (ACE2) is a host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inhibiting the interaction between the envelope spike glycoproteins (S-proteins) of SARS-CoV-2 and ACE2 is a potential antiviral therapeutic approach, but little is known about how dietary compounds interact with ACE2. The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3’,4’-hydroxylation inhibit recombinant human (rh)ACE2 activity….
Human coronavirus dependency on host heat shock protein 90 reveals an antiviral target - Rapid accumulation of viral proteins in host cells render viruses highly dependent on cellular chaperones including heat shock protein 90 (Hsp90). Three highly pathogenic human coronaviruses, including MERS-CoV, SARS-CoV and SARS-CoV-2, have emerged in the past 2 decades. However, there is no approved antiviral agent against these coronaviruses. We inspected the role of Hsp90 for coronavirus propagation. First, an Hsp90 inhibitor, 17-AAG, significantly suppressed MERS-CoV propagation in cell…
COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management - At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective…
Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection - No abstract
Pharmacophore modelling of vanillin derivatives, favipiravir, chloroquine, hydroxychloroquine, monolaurin and tetrodotoxin as M(Pro) inhibitors of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) - OBJECTIVES: The aim of this study was to use Ligand-based pharmacophore modelling approach for four established antiviral drugs, namely remdesivir, lopinavir, ritonavir and hydroxychloroquine for COVID-19 inhibitors as training sets. In this study Twenty vanillin derivatives together with monolaurin and tetrodotoxin were used as test sets to evaluate as potential SARS-CoV-2 inhibitors. The Structure-based pharmacophore modelling approach was also performed using 5RE6, 5REX and 5RFZ in order to…
AN EFFICIENT METHODOLOGY TO MANAGE THE ADMISSIONS IN HOSPITALS DURING THE PANDEMICS SUCH AS COVID 19 -
SARS-CoV-2 예방을 위한 mRNA기반 항원보강제 혼합물 합성 방법 - 본 발명은 SARS-CoV-2(코로나 바이러스) 예방을 위한 mRNA 항원보강제에 관한 것으로 코로나 바이러스에 대한 백신으로서 상기의 항원에 대한 예방을 목적으로 하고 있다. 아이디어에는 보강제에 해당하는 완전프로인트항원보강제(CFA)와 불완전프로인트항원보강제(IFA), 번역과 안정성의 최적화가 된 mRNA, mRNA 운반체, 양이온성 지질 나노입자(lipid nanoparticles)로 구성되며 기존의 백신에 비해 효율성과 안정성의 측면에서 더 향상된 효과를 가지고 있다.
Methods for treating Arenaviridae and Coronaviridae virus infections - Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I:
wherein the ’ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
++Atemschutz-Baukastensystem, das aufweist:
+Vorrichtung zur Übergabe von mit Krankheitserregern kontaminierten Gegenständen oder Erzeugnissen nach einer Dekontamination, umfassend eine Einrichtung zur Dekontamination der mit Krankheitserregern kontaminierten Gegenstände oder Erzeugnisse mit mindestens einer UV-Strahlungsquelle (24), eine Durchzugseinrichtung mit Ein- und/oder Ausgabebereichen für die kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse, dadurch gekennzeichnet, dass die Durchzugseinrichtung im Eingang bzw. im Ausgang zum Ein- und/oder Ausgabebereich angeordnete sich paarweise gegenüberliegende Walzen (17) und Räder (4) umfasst, die zum Einzug bzw. zur Ausgabe der kontaminierten bzw. dekontaminierten Gegenstände oder Erzeugnisse vorgesehen sind, wobei die Walzen (17) und die Räder (4) durch im Ein- und/oder Ausgabebereich angeordnete Sensoren (23) und einer elektronische Kontrolleinheit (27) in Bewegung bringbar sind, wobei die Gegenstände oder Erzeugnisse in den Bereich der Einrichtung zur Dekontamination förderbar sind, der zwischen den paarweise angeordneten Walzen (17) und Rädern (4) vorgesehen ist, welcher sich gegenüberliegende Platten (25) aus Quarzglas oder einem UV-transparenten Polymermaterial, wie Graphen oder Kunstglas umfasst, über bzw. unter welchen die UV-Strahlungsquelle (24) angeordnet ist, welche als UVC-LED-Leiste und/oder Modul mit mindestens einer LED-Lampe ausgebildet ist.
제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. [화학식 1] .
+ JPEG
+ 112020094463686-pat00017.jpg
+ 48
+ 135
新型冠状病毒中和性抗体滴度检测ELISA试剂盒 - 本发明提供一种新型冠状病毒中和性抗体滴度检测ELISA试剂盒,其中包括:包被有生物素‑链霉亲和素标记的人ACE2蛋白的酶标板、辣根过氧化酶标记的新型冠状病毒RBD蛋白、新型冠状病毒中和性抗体阳性对照、包被液、洗涤液、稀释液、封闭液、显色液和终止液等。该试剂盒具有成本低,操作简单,高灵敏度、高特异性、高准确度的特点,可用于新型冠状病毒中和抗体的批量、快速检测。
Zahnbürstenaufsatz, elektrische Versorgungseinheit einer elektrischen Zahnbürste, elektrische Zahnbürste mit einem Zahnbürstenaufsatz, Zahnbürste sowie Testaufsatz für eine elektrische Zahnbürste -
++
Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.
+Hygiene-Mundstückelement (100), aufweisend einen ersten Endabschnitt (103), welcher ausgebildet ist zur Verbindung mit einem Griff-Mundstückelement (200) einer Wasserpfeife (400) und aufweisend einen zweiten Endabschnitt (104), welcher als mundseitiges, freies Ende ausgebildet ist, wobei das Hygiene-Mundstückelement (100) ein erstes Filterelement (101) aufweist, wobei das erste Filterelement (101) wenigstens ein adsorbierendes Material umfasst und/oder wobei das Hygiene-Mundstückelement (100) ein zweites Filterelement (102) aufweist, wobei das zweite Filterelement (102) Metalloxid und/oder elektrostatisch geladene Fasern umfasst.
Pimp My Microwave - Comments
Intel’s disruption is now complete - Comments
Don’t use third party auth to sign in - Comments
Save like a pessimist, invest like an optimist - Comments
Handmade Seattle – virtual low-level programming conference - Comments
Universal DOOM – a single EXE for DOS 6, and Windows 95 to Windows 10 - Comments
Reverse-engineering the classic MK4116 16-kilobit DRAM chip - Comments
Plants can grow quickly or accurately, but not both - Comments
What a great technical resume can do for you - Comments
Using Matrix to replace proprietary and centralized chat apps - Comments
The Kremlin Prepares for a Biden Presidency - Even in Moscow, there is accumulated disappointment and fatigue with Trump and all that his Presidency failed to deliver.
Is This a Coup, or Just Another Trump Con? - A post-election report from Minsk-on-the-Potomac.
The Pandemic’s Winter Surge Is Here - The numbers are rising. Our leaders must react quickly to prevent unnecessary deaths.
Why Trump Carried Out His Pentagon Purge - With his Administration coming to a close, the President is still reshaping the government around himself.
What My Ninety-Two-Year-Old Mother and Her Cohort Have Taught Us This Election - Her generation had a more visceral understanding of what was at stake than many of us did. They had seen men like Trump before.
Bengaluru race results - Neil Devaney trained Northern Alliance (M. Prabhakaran up), won the Karnataka Police Trophy, the main event of the races held here on Saturday (Nov.
Bengaluru race results - Neil Devaney trained Northern Alliance (M. Prabhakaran up), won the Karnataka Police Trophy, the main event of the races held here on Saturday (Nov.
Top news of the day: Narendra Modi slams ‘expansionist forces’, says India will give fierce reply if tested, and more - The major news headlines of the day, and more.
India in Australia: Touring Indians clear COVID-19 test, begin physical training - India are scheduled to play three ODIs, three T20s and a four-Test series on the tour, starting with T20Is from November 27
Prajnesh enters semifinals of Cary Challenger - It will be Prajnesh’s second last-four appearance this season after he resumed competing on the tour
Asaddudin Owaisi | The champion of identity politics - The young Owaisi, who wanted to be a lawyer, had to file his nomination papers to contest the 1994 Andhra Pradesh Assembly election
Deepavali celebrated with gusto in Hyderabad - The two-hour time band and the limited use of green crackers was observed more in the breach
Gupkar alliance formed solely to safeguard interests of J-K residents: Mehbooba - Ms. Mehbooba’s remarks came as the alliance partners are currently engaged in consultations on seat-sharing for the District Development Council (DDC) polls.
LoC firings: A soldier’s father awaits his body during Diwali - Hrishikesh Jondhale was among four personnel of the Army who were killed during cross LOC firing by Pakistani soldiers
Assam governor, CM mourn killing of Army jawan from state in Pakistani shelling - Rai was among the five security forces personnel and six civilians who lost their lives after Pakistan indulged in heavy cross-border shelling along the Line of Control (LoC) on Friday.
Coronavirus: Austria locks down as new wave grips Europe - Austrians are urged not to meet people from outside their households as hospitals feel the pressure.
The secret relationship destroyed by war - Cousins Mehdi and Melek kept their relationship secret – then war brought it to a sudden end.
EU-UK talks: ‘Make or break’ moment approaching, say both sides - The two sides say big gaps remain between them as the “moment of truth” is nearing for an agreement.
Dutch police give ‘stop paedophile hunts’ warning after Arnhem death - A police chief warns against vigilantism after a retired teacher is beaten to death by teenagers.
Paris attacks: France remembers night of terror amid jihadist threat - On high alert, France is mourning the 130 people murdered in co-ordinated attacks five years ago.
This farmer’s field was once a powerful stronghold in Iron Age Norway - We know about it all because a farmer wanted to dig a drainage ditch. - link
Hackers can use just-fixed Intel bugs to install malicious firmware on PCs - Computer makers are in the process of patching Boot Guard. Have you installed it yet? - link
We’ll need more than one vaccine to beat the pandemic - All COVID vaccine candidates work in different ways; none will be perfect for all. - link
Fireball is Werner Herzog’s ode to space rocks - New Apple TV+ doc from German auteur examines how meteorites have shaped human history. - link
Hackers sponsored by Russia and North Korea are targeting COVID-19 researchers - Three nation-state sponsored groups are targeting organizations throughout the world. - link
My wife told me to take the spider out instead of killing him. -
++Went out, had a few drinks. Nice guy. He’s a web designer. +
+ submitted by /u/WallabyProGamer
[link] [comments]
It’s a 5 minute walk from my house to the pub. It’s a 30 minute walk from the pub to my house. -
++The difference is staggering. +
+ submitted by /u/flotstildeath
[link] [comments]
Not saying my Ex was fat -
++But it took a year for my memory foam mattress to forget her. +
+ submitted by /u/_BeyondUnderstanding
[link] [comments]
3 nuns die and go to Heaven -
++At the Pearly Gates, St. Peter tells them that they must each answer a biblical question to get in, but he reassures them that they’re quite easy. +
++“Who was the first woman?” He says to the first nun. +
++“Eve.” The gates swing open and she walks in. +
++“Where did Eve live?” He says to the second nun. +
++“The Garden of Eden.” The gates swing open once more. +
++“Now, seeing as you’re the Mother Superior, you must answer a more difficult question, what was the first thing Eve said when she saw Adam?” St. Peter says to the third nun. +
++“Oh, that’s a hard one…” +
++The gates swing open. +
+ submitted by /u/Randomguy6282
[link] [comments]
What is the most expensive video streaming service right now? -
++College. +
+ submitted by /u/Randomguy6282
[link] [comments]