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+ + + +Safety and Immunogenicity of a Booster Vaccination With an Adapted Vaccine - Conditions: SARS-CoV2 Infection
Interventions: Biological: PHH-1V81; Biological: Comirnaty Omicron XBB1.5
Sponsors: Hipra Scientific, S.L.U
Active, not recruiting
A Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Combined Modified RNA Vaccine Candidate Against COVID-19 and Influenza. - Conditions: Influenza; COVID-19
Interventions: Biological: Influenza and COVID-19 Combination A; Biological: Licensed influenza vaccine; Biological: COVID-19 Vaccine; Biological: Influenza and COVID-19 Combination B; Biological: Placebo
Sponsors: BioNTech SE; Pfizer
Not yet recruiting
Transcranial Pulse Stimulation (TPS) in Post-COVID-19 - Conditions: Post-COVID-19 Syndrome; Fatigue
Interventions: Device: Transcranial pulse stimulation Verum; Device: Transcranial pulse stimulation Sham
Sponsors: Medical University of Vienna; Campus Bio-Medico University
Not yet recruiting
Evaluate the Efficacy and Safety of âFormosa 1-Breath Free (NRICM101)â in Subjects With the Symptoms of COVID-19 or Influenza-like Disease - Conditions: Influenza Viral Infections; COVID-19
Interventions: Drug: Formosa 1-Breath Free (NRICM101); Drug: Placebo control drug
Sponsors: China Medical University Hospital; Tian-I Pharmaceutical,. Co. Ltd.; China Medical University, China; Qualitix Clinical Research Co., Ltd.
Not yet recruiting
A Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of Booster Vaccination With Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell) - Conditions: COVID-19
Interventions: Biological: Recombinant COVID-19 (XBB) Trimer Protein Vaccine (Sf9 Cell); Biological: Recombinant COVID-19 Variant Vaccine (Sf9 Cell); Biological: Placebo
Sponsors: WestVac Biopharma Co., Ltd.; WestVac Biopharma (Guangzhou) Co., Ltd.
Not yet recruiting
Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID - Conditions: Long Covid19; Exercise Intolerance, Riboflavin-Responsive
Interventions: Behavioral: Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Behavioral: Light Stretching/Breathing Exercises
Sponsors: Columbia University; New York University
Recruiting
A Pilot Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues - Conditions: Multiple Sclerosis; Long COVID; Long Covid19; Obese; Obesity; Obesity, Morbid; Acute Leukemia in Remission
Interventions: Drug: Liraglutide Pen Injector [Saxenda]; Other: Medication Diary
Sponsors: University of Chicago
Not yet recruiting
Safety and Immunogenicity of Recombinant COVID-19 Trivalent Protein Vaccine ïŒCHO CellïŒLYB002V14 in Booster Vaccination - Conditions: SARS-CoV-2; COVID-19 Vaccine
Interventions: Biological: 30ÎŒg dose of LYB002V14; Biological: 60ÎŒg dose of LYB002V14; Biological: placebo
Sponsors: Guangzhou Patronus Biotech Co., Ltd.; Yantai Patronus Biotech Co., Ltd.
Not yet recruiting
Exercise Training Using an App on Physical Cardiovascular Function Individuals With Post-covid-19 Syndrome - Conditions: Post-Acute COVID-19 Syndrome
Interventions: Behavioral: Exercise; Behavioral: Control
Sponsors: University of Nove de Julho
Not yet recruiting
COVID-19 Vaccine Effectiveness Against Recurrent Infection Among Lung Cancer Patients and Biomarker Research - Conditions: COVID-19 Recurrent; Lung Cancer; Vaccination; Antibody; Chemotherapy; Immune Checkpoint Inhibitor
Interventions: Biological: Any Chinese government-recommended COVID-19 booster vaccine
Sponsors: Peking Union Medical College Hospital
Recruiting
Excessive daytime sleepiness is associated with impaired antibody response to influenza vaccination in older male adults - CONCLUSION: Our results provide an additional and easily measured variable explaining poor vaccine effectiveness in older adults. Our results support that gaining sufficient sleep is a simple non-vaccine interventional approach to improve influenza immune responses in older adults. Our findings extend the literature on the negative influence of excessive daytime sleepiness on immune responses to influenza vaccination in older male adults.
Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS) - CONCLUSIONS: Ferritin is a clinically useful biomarker in ARDS and is associated with worse patient outcomes. These results provide support for prospective interventional trials of immunomodulatory agents targeting IL-18 in this hyperferritinaemic subgroup of patients with ARDS.
Sutimlimab suppresses SARS-CoV-2 mRNA vaccine-induced hemolytic crisis in a patient with cold agglutinin disease - Cold agglutinin disease (CAD) is a rare form of acquired autoimmune hemolytic anemia driven mainly by antibodies that activate the classical complement pathway. Several patients with CAD experience its development or exacerbation of hemolysis after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or after receiving the SARS-CoV-2 mRNA vaccine. Therefore, these patients cannot receive an additional SARS-CoV-2 mRNA vaccination and have a higher risk of severe SARS-CoV-2âŠ
COVID-19 in Dental Practice Is Prevented by Eugenol Responsible for the Ambient Odor Specific to Dental Offices: Possibility and Speculation - Dental professionals routinely work in proximity to patients even when either or both of them have suspected or confirmed COVID-19. The oral cavity also serves as a reservoir for SARS-CoV-2 because the virus is present in and replicates in oral secretions (saliva and gingival crevicular fluid), oral tissues (salivary gland and periodontal tissue), and oral microenvironments (gingival sulcus and periodontal pocket). Despite a high risk of SARS-CoV-2 infection, the prevalence of COVID-19 inâŠ
Inhibition of Porcine Deltacoronavirus Entry and Replication by Cepharanthine - Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus (CoV) that mainly causes acute diarrhea/vomiting, dehydration, and mortality in piglets, possessing economic losses and public health concerns. However, there are currently no proven effective antiviral agents against PDCoV. Cepharanthine (CEP) is a naturally occurring alkaloid used as a traditional remedy for radiation-induced symptoms, but its underlying mechanism of CEP against PDCoV has remained elusive. TheâŠ
Does denosumab exert a protective effect against COVID-19? Results of a large cohort study - CONCLUSION: Our study confirms that denosumab may be safely continued in COVID-19 patients. RANK/RANKL inhibition seems associated with a reduced incidence of symptomatic COVID-19, particularly among the elderly.
Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques - Next-generation SARS-CoV-2 vaccines are needed that induce systemic and mucosal immunity. Murine pneumonia virus (MPV), a murine homolog of respiratory syncytial virus, is attenuated by host-range restriction in nonhuman primates and has a tropism for the respiratory tract. We generated MPV vectors expressing the wild-type SARS-CoV-2 spike protein (MPV/S) or its prefusion-stabilized form (MPV/S-2P). Both vectors replicated similarly in cell culture and stably expressed S. However, only S-2P wasâŠ
Efficacies of S-nitrosoglutathione (GSNO) and GSNO reductase inhibitor in SARS-CoV-2 spike protein induced acute lung disease in mice - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially surfaced in late 2019, often triggers severe pulmonary complications, encompassing various disease mechanisms such as intense lung inflammation, vascular dysfunction, and pulmonary embolism. Currently, however, thereâs no drug addressing all these mechanisms simultaneously. This study explored the multi-targeting potential of S-nitrosoglutathione (GSNO) and N6022, an inhibitor of GSNO reductase (GSNOR) on markersâŠ
Comparative transcriptome analysis of SARS-CoV-2, SARS-CoV, MERS-CoV, and HCoV-229E identifying potential IFN/ISGs targets for inhibiting virus replication - INTRODUCTION: Since its outbreak in December 2019, SARS-CoV-2 has spread rapidly across the world, posing significant threats and challenges to global public health. SARS-CoV-2, together with SARS-CoV and MERS-CoV, is a highly pathogenic coronavirus that contributes to fatal pneumonia. Understanding the similarities and differences at the transcriptome level between SARS-CoV-2, SARS-CoV, as well as MERS-CoV is critical for developing effective strategies against these viruses.
Venomous gland transcriptome and venom proteomic analysis of the scorpion Androctonus amoreuxi reveal new peptides with anti-SARS-CoV-2 activity - The recent COVID-19 pandemic shows the critical need for novel broad spectrum antiviral agents. Scorpion venoms are known to contain highly bioactive peptides, several of which have demonstrated strong antiviral activity against a range of viruses. We have generated the first annotated reference transcriptome for the Androctonus amoreuxi venom gland and used high performance liquid chromatography, transcriptome mining, circular dichroism and mass spectrometric analysis to purify and characterizeâŠ
Targeting the tissue factor coagulation initiation complex prevents antiphospholipid antibody development - Antiphospholipid antibodies (aPL) in primary or secondary antiphospholipid syndrome (APS) are a major cause for acquired thrombophilia, but specific interventions preventing autoimmune aPL development are an unmet clinical need. While autoimmune aPL cross-react with various coagulation regulatory proteins, lipid-reactive and COVID-19 patient-derived aPL recognize the endo-lysosomal phospholipid lysobisphosphatidic acid (LBPA) presented by the cell surface expressed endothelial protein C receptorâŠ
Tissue factor binds to and inhibits interferon-α receptor 1 signaling - Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation and coagulation-dependent inflammation. TF also exerts protective effects through unknown mechanisms. Here, we showed that TF bound to interferon-α receptor 1 (IFNAR1) and antagonized its signaling, preventing spontaneous sterile inflammation and maintaining immune homeostasis. Structural modeling and direct binding studies revealed binding of the TF C-terminal fibronectin III domain to IFNAR1, whichâŠ
Avian coronavirus infectious bronchitis virus Beaudette strain NSP9 interacts with STAT1 and inhibits its phosphorylation to facilitate viral replication - Avian coronavirus, known as infectious bronchitis virus (IBV), is the causative agent of infectious bronchitis (IB). Viral nonstructural proteins play important roles in viral replication and immune modulation. IBV NSP9 is a component of the RNA replication complex for viral replication. In this study, we uncovered a function of NSP9 in immune regulation. First, the host proteins that interacted with NSP9 were screened. The immune-related protein signal transducer and activator of transcriptionâŠ
Cholesterol depletion inhibits rabies virus infection by restricting viral adsorption and fusion - Rabies is an ancient zoonotic disease caused by the rabies virus (RABV), and a sharp increase in rabies cases and deaths were observed following the COVID-19 pandemic, indicating that it still poses a severe public health threat in most countries in the world. Cholesterol is one of the major lipid components in cells, and the exact role of cholesterol in RABV infection remains unclear. In this study, we initially observed that cellular cholesterol levels were significantly elevated in RABVâŠ
Clinical utility of quantitative immunoassays and surrogate virus neutralization tests for predicting neutralizing activity against the SARS-CoV-2 Omicron BA.1 and BA.5 variants - Developing new antibody assays for emerging SARS-CoV-2 variants is challenging. SARS-CoV-2 surrogate virus neutralization tests (sVNT) targeting Omicron BA.1 and BA.5 have been devised, but their performance needs to be validated in comparison with quantitative immunoassays. First, using 1749 PRNT-positive sera, we noticed that log-transformed optical density (OD) ratio of wild-type (WT) sVNT exhibited better titer-correlation with plaque reduction neutralization test (PRNT) than % inhibitionâŠ
Coloradoâs Top Court Kicked Trump Off the Ballot. Will the Supreme Court Agree? - A legal scholar analyzes how the nine Justices are likely to view the blockbuster decision. - link
When Americans Are the Threat at the Border - Many people charged with trafficking in Tucson are U.S. citizens, suffering from the same problems of poverty and addiction that plague the rest of the country. - link
How Netanyahuâs Right-Wing Critics See Israelâs Future - Danny Danon, the former Israeli Ambassador to the United Nations, believes thereâs no path forward for a Palestinian state. - link
An Unpermitted Shooting Range Upends Life in a Quiet Town - Residents of Pawlet, Vermont, were accustomed to calm and neighborly interactions. Then a new resident moved in. - link
The Disturbing Impact of the Cyberattack at the British Library - The library has been incapacitated since October, and the effects have spread beyond researchers and book lovers. - link
+What itâs like to study a world facing unprecedented changes. +
++2023 is the hottest year in at least 174 years and recent months have been the hottest in 125,000 years. All of that warming led to deadly heat waves, disease outbreaks, floods, droughts, and record low ice levels around Antarctica. +
++The extreme weather this year stems in part from natural variability, including a powerful El Niño warming pattern in the Pacific Ocean that reshaped weather around the world. But beneath these cycles, humanityâs ravenous appetite for coal, oil, and natural gas is driving up concentrations of heat-trapping gasses in the atmosphere to levels the Earth hasnât witnessed for 3 million years. +
++This year may be the first time that annual temperatures have risen 1.5 degrees Celsius, 2.7 degrees Fahrenheit, above the global average at the dawn of the industrial revolution. Under the 2015 Paris agreement, just about every country in the world agreed to keep the planetâs average temperature from rising more than 2°C, striving to stay below 1.5°C. A single year rising past this level doesnât mean this target is toast, but if people keep heating up the planet, a year like 2023 will become one of the coolest weâll experience in the rest of our lives. +
++Earlier this month, leaders from around the world just wrapped the largest climate conference in history aimed at preventing this outcome. The COP28 meeting in the United Arab Emirates produced an agreement that explicitly called on countries to reduce fossil fuel use for the first time and provide more money to countries facing destruction worsened by warming. But the commitments made so far are still not enough to limit warming to 1.5°C, and greenhouse gas emissions continue to rise. +
++Half a world away, scientists who study this warming and its consequences gathered at the American Geophysical Union conference in San Francisco. Climate change is not an abstraction for these researchers, and many are observing it in real time, often in areas that have personal stakes for them. Looking back on the hottest year on record and what little humanity has done about it, some are reckoning with how their own work fits in. From the retreat of Arctic ice to rising demand for air conditioning, scientists with their fingers on the pulse of the planet are experiencing a mix of optimism, dread, and urgency as they endeavor to make their research practical in the real world. +
+ ++I spoke with seven researchers studying Earthâs changes from different angles. Their comments below have been lightly edited. +
++Daniel Schindler at the University of Washington researches how climate change affects aquatic ecosystems, including Alaskaâs sockeye, chinook, and chum salmon. He was one of several scientists presenting the National Oceanic and Atmospheric Administrationâs Arctic Report Card for 2023 at the conference. The Arctic has been warming four times faster than the rest of the planet, and this year, the region saw its warmest summer since 1900 (when record-keeping began), with knock-on effects like Canadaâs worst wildfire season on record. As negotiators in the United Arab Emirates bickered over the future of the planet, Schindler noted that the effects of climate change are underway now, and itâs already reshaping ecosystems and human communities: +
++++I think the reality is, if you look at Western Alaska, climate change is not something thatâs coming down the pipe somewhere in the future. It is happening now, itâs been happening for decades. And whether youâre talking about fish or people or birds, there are real impacts that we need to deal with right now. +
++And when you hear about whatâs going on at COP28, there may be a reason to be optimistic. But the reality is, we need action on the ground right now, not to necessarily turn around climate change immediately, but to deal with the fact that weâre going to be challenged by it, now and for decades to come, so we need action now at local scales. +
+
+Rick Thoman, who studies Alaskaâs climate and weather at the University of Alaska Fairbanks, echoed the call for more immediate steps to deal with global warming, noting that the Arctic has been at the leading edge of climate change long before it reached the extremes seen this year. The communities there may have important lessons for the rest of the world: +
++++As Alaskans, as peoples in the Arctic, we are living this change every day. And we have no choice, no choice at all, other than to work with whatâs happening. We need the big picture solutions, but everyone â Indigenous communities, all the people of the Arctic â are having to adapt right here, right now. It didnât start today. It didnât start yesterday. This has been ongoing for years. Listen to the elders. This change has been happening for decades, century-scale changes. And Arctic peoples are still here and weâre still going to be here. +
+
+Sarah Cooley, an assistant professor at the University of Oregon, is studying how climate change is altering ice in places like coastal Alaska and has found that when you zoom in, the way it affects people can be quite complicated. How ice melts and the impacts it has on communities can vary drastically, even in nearby regions. With COP28 still falling short of global climate goals, Cooley is also looking into the way the success or failure of international negotiations will manifest on the ground: +
++++In this broader context of warming climate, loss of ice, thawing permafrost, threats of coastal erosion, and sea level rise, thatâs kind of this giant signal that each person experiences differently depending on their interaction with their environment. +
++I get really excited about being able to do research that is locally relevant. One of the things we did in this project is weâre thinking about how Paris climate agreement targets translate to local on-the-ground experiences. If you tell somebody that the Earth is going to warm by 1.5°C or 2°C, thatâs an incredibly abstract concept because the difference to us of two degrees doesnât mean anything. But if you can translate that experience of two degrees warming to an actual on-the-ground experience thatâs highly localized â so letâs say a loss of 30 days of ice versus 50 days of ice, which is a huge deal for someone living in the community to lose a month of ice versus losing two months of ice â that to me is really exciting work that we can kind of take large-scale big numbers that are really abstract and bring them down to a local experience. +
+
+Robert Green, a scientist at NASAâs Jet Propulsion Laboratory, is leading a project to track mineral dust using instruments on the International Space Station. This is an important mechanism that can change air quality, the flow of nutrients across the planet, and the amount of sunlight hitting the Earth, which can cool the planet. Green is also keeping an eye on methane, a greenhouse gas with about 30 times the warming potential of carbon dioxide. At COP28, countries made new pledges to curb methane, and Green said scientists can help them meet their targets: +
+++ ++We can tell people where the point sources of methane are, where leaks are happening, and give people the information to address those leaks. And thatâs something that is just so important to do. Nobody wants to waste money out of a leaking pipeline. Letâs go ahead and fix those leaks, and we also reduce the impact of methane for climate change. +
++Iâm excited to be making a difference. Iâm an optimistic person, and we can work together to address this problem. Itâs not an easy problem, but the pieces are coming together. So Iâm going to remain hopeful. +
+
+Stepp Mayes, a doctoral student at the University of Southern California, studies how people use electricity and the ensuing consequences for the climate and for health. Lately heâs been examining the growing demand for air conditioning as temperatures rise and the stresses that imparts on the power grid. As temperatures go up, people install more cooling systems, run them longer, and crank them up during the hottest times of day. Thatâs often when the power grid is struggling the most to provide electricity. The extreme heat this year coupled with record-high energy demand signals that this work is only going to become more important: +
++++It makes me nervous. Thereâs a big intersection because weâre all about looking at the relationship between temperature and AC use and AC penetration. I think that people are directly responding to increasing temperature, and I think we are going to see that continue as temperatures continue to rise, where our reliance on AC â as a public health issue, and as a grid issue â becomes larger and larger. +
+
+Aliyah Griffith, a doctoral student at the University of North Carolina Chapel Hill, studies coral reef infrastructure around places like Barbados, from satellites and from the water. Griffith is also the founder and CEO of Mahogany Mermaids, a nonprofit that works to encourage women of color to pursue careers in science, particularly in aquatic fields. The extreme temperatures this year, including heat waves in the ocean, have renewed her determination: +
++++My family is from Barbados. Not only does that make me feel more driven to answer questions from a scientistâs perspective â how can we help the reefs? How can we understand what they need and what theyâre facing? â but also: What do the communities need? How can we interact with their local governments, their local institutions, and understand where they can be elevated? You have to really respect a lot of the work and effort that theyâve already done to see what can change in the future. +
+
+Gordon Walker, a researcher at the University of Hawaiâi at Manoa, studies paleoclimate, particularly how past shifts in the climate and weather influenced historical events. For instance, changing climate conditions in Africa and the Caribbean were a factor in the slave trade and may have played a part in uprisings. For Walker, the role of the climate in historical periods of unrest is adding urgency for the need to fill in data gaps as the climate breaches records, particularly in regions experiencing the most acute impacts of warming today: +
+++For me â my focus being the Caribbean and Africa, and the transatlantic slave trade, and climate variability associated with those regions and the historical event of the trade â I think that itâs important for us to collect data on regions in the global South â the Caribbean, South America, Africa â because a lot of the science and research is focused on the global North. +
++I think itâs imperative, especially in areas where we donât have a lot of data, to start collecting data and applying the powers or the tools of analysis that we have for climate to the global South. Because a lot of countries in those regions are not necessarily resource-poor in terms of raw material but resource-poor in terms of economies and having the ability to respond to extreme climate. So I think the greater lead time we have with projections based on studying the past, the better for those countries to be able to respond, especially with limited economies, as compared to countries in the global North. +
+
+Ravenous, carnivorous, and totally yoked: How men in tech have evolved. +
++Silicon Valley is embracing a new era of masculinity. Its leaders are powerful, virile, and swole. They practice Brazilian jiujitsu and want to fight each other in a cage. They can do 200 push-ups while wearing a 20-pound weighted vest. They can spend $44 billion on a website as a sort of elaborate joke. They can do all this because if these tech executives are one thing above all else, it is this: They are men. +
++This renewed sense of masculine dominance hit a fever pitch in 2023. The softer, soulful leaders of Silicon Valleyâs previous decades have vacated. Gone is the delicate, ascetic presence of Jack Dorsey and the laissez-faire leadership of Sheryl Sandberg. Gone are the girl bosses. In their absence, the richest, most powerful men in tech are leading Silicon Valley toward a more macho future, one in which strength can be measured in muscles, women are absent from the boardroom, and ruthlessness is a virtue. +
++âAll of Silicon Valley reminds me of the first Top Gun movie: the abundance of testosterone, like 1970s, 1980s all over again,â said Manu Cornet, a cartoonist and software engineer who formerly worked at Twitter, now X. âItâs not even sarcastic or second degree.â +
++âItâs a very jacked up movement,â said Glenn Kelman, the CEO of Redfin. âThe people I know are thinking about testosterone and eating 500 grams of protein a day. They are ravenous, carnivorous, and totally yoked.â +
++Only two decades ago, Silicon Valleyâs expression of masculinity was at odds with the status quo. Tech champions were nerds and geeks: skinny outliers in hoodies armed with a nonconformist mentality â a mindset that would prove indispensable to the creation of dozens of companies that launched the digital age. Then came the Obama years, when tech companies were propped up as progressive bastions of diversity and forward-thinking corporate culture. Under the influence of Sheryl Sandberg, Silicon Valley ceded board seats and C-suite jobs to more and more women. +
++But more recently, these same Silicon Valley companies have begun to look like the conventionally bloated behemoths at the pinnacle of corporate culture. Their leaders, too, have adopted a performance of masculinity thatâs strikingly conventional and includes angry rhetoric, muscular physiques, and a newfound interest in physical combat. The men responsible for building the products that touch the daily lives of billions of people display an increasing preoccupation with flaunting masculine bravado. Itâs not just for show, either. The way these powerful men run their companies is impacting who is considered welcome in Silicon Valley. +
++Today, there are fewer women in tech leadership roles than only a few years ago, with women representing 28 percent of tech leadership (it was 33 percent at its height). And this number may only be decreasing: A 2022 McKinsey study found that women are leaving corporate roles faster than ever before and that they have less representation in technical roles than they did in 2018. +
++While it looks like Silicon Valley is regressing, thereâs a chance this suddenly hypermasculine culture is just the next logical step in its evolution. Like Wall Street before it, the tech industry is ultimately hell-bent on making as much money as possible. And as economic conditions have shifted, preserving progressive values isnât necessarily part of that mission. +
++âThe truth is that, through these ups and downs, women and people of color havenât made much progress,â said Kelman. âItâs been a tragedy. Iâve been doing this 30 years â I really thought we would be different by now.â +
++Only a few years ago, it was not so easy to be so unapologetically male in Silicon Valley. +
++These were the 2010s, when Silicon Valley outwardly championed diversity. At the time, having an all-male executive team was considered regressive and slightly embarrassing. Companies introduced diversity initiatives, venture capital firms loudly backed startups led by women and people of color, and the media wrote glowing profiles about female CEOs. +
++âWhen I started working in this space [a decade ago], it was very male dominated, but everyone pretended to include women,â said Joelle Emerson, CEO of Paradigm Strategy, a Silicon Valley consulting firm that specializes in diversity and inclusion. âNow, itâs still very male dominated, but nobody feels the need to pretend that itâs true.â +
++These years of PR-friendly progress were only heightened by the pandemic, which ushered in growing awareness surrounding social injustice, racial inequity, and income disparity. Tech employees, suddenly with ample time on their hands and without access to the officeâs free-flowing kombucha, began questioning their role not just at work, but in society. +
++âI got to this point pre-Covid where I was hustling, and then Covid hit and I had this awakening,â said Brent Boeckman, a coach for the menâs wellness community Evryman who worked in sales at startups and enterprise tech companies for more than a decade. âYouâre working but for what?â +
++Such personal revelations were highly inconvenient to the bottom line of Silicon Valleyâs many corporations. Tech employees began putting in minimal effort at work or quitting their jobs to pursue passion projects. The media wrote about âquiet quitting,â âthe Great Resignation,â and labor rights. The status quo was shifting, and tech executives felt it. To appease their employeesâ demands, they adopted a meeker stance. +
++âI would talk to CEOs â all men â who would say, âIâm not really enjoying my job. Iâm the king of the jungle, and yet Iâm tiptoeing around my employees,ââ said Kelman. +
++By the end of 2022, FTX collapsed and the crypto bubble burst. An uneasy pall fell over the valley. There was a sense of âHoly shit, thereâs nothing there!â said Ed Zitron, founder of the consumer tech PR firm EZPR. It was a revelation that made people insecure: One of the most buzzworthy technologies Silicon Valley had produced in decades appeared to be nothing more than hype. As the economy tightened, the venture capital frenzy cooled, and many of the unprofitable companies of Silicon Valley drew their last breaths. +
++âThere was something that cracked in them,â said Zitron. âThey saw the world they loved going away, while at the same time making more money than they ever made.â +
++To fully understand how we reached this moment of hypermasculinity, you must look farther back, before the pandemic, to 2017, when a pair of arms were first photographed emerging from the sleeves of a snug black polo shirt at a conference in Sun Valley. The arms were tanned and vascular, and they belonged to Jeff Bezos, a formerly reedy bookseller whose public image up until that point had embodied a sort of endearing, sexless twerpiness. +
++Bezosâs new appearance signaled a shift in the tech executiveâs aesthetic makeup. Previously, the male costume of Silicon Valley was one of studied nonchalance: rumpled T-shirt, messy hair, anemic build â an appearance meant to convey that what actually mattered was the merit of a manâs ideas, not his physical strength. +
++But as Silicon Valley generated the richest men on the planet, these men, in turn, were deploying their millions to become more closely aligned with the prototypical image of masculine desire, whether by employing Tom Cruiseâs personal trainer or purchasing a full head of hair. +
+ ++It was an inflection point that slowly rippled through the ranks of Silicon Valley. Soon, venture capitalists were posting shirtless photos of themselves on Twitter, flaunting their gains and dropping fitness routines. The message was clear: Physical strength and stamina were necessary prerequisites to building a massive tech company. The more you demanded of yourself physically, the more you could demand of your company. +
++There was also the reality that many tech companiesâ leading executives, Bezos included, had reached middle age. Mortalityâs inevitable creep was closing in. It seemed unfair â cruel, even â that people who had acquired all that the material realm had to offer might be forced to face a fate so pedestrian as old age and, eventually, death. +
++Soon, the notion of living a healthy life for as long as absolutely possible became a core component of Silicon Valley dogma. A new cohort of health and longevity influencers emerged. Among them is Andrew Huberman, a buff, straight-talking Stanford professor of neurobiology who recommends HIIT workouts and cold baths on his popular podcast, Huberman Lab. And there is Bryan Johnson, a former venture capitalist, who is attempting to achieve his mantra, âDonât Die,â through a longevity regime that involves a strict diet, going to bed at 8:30 pm, and tracking his nightly erections. +
++When it comes to the Bezos effect, there are some very âboring economic issuesâ at play, said Tomas Chamorro-Premuzic, a business psychology professor at Columbia University. âThere is a cycle in which innovation leads to growth, and then growth hinders innovation.â If the leaders of big tech companies are performing an expression of masculinity identity that feels infinitely more traditional compared to what was championed only a few decades ago, it might be because their companies have become infinitely more traditional. +
++The original founders of todayâs tech juggernauts â people who were once âanarchic and rebelliousâ â have become the institution, according to Chamorro-Premuzic. âThese startups matured and started getting lawyers, HR people, sales people,â he said. âThey became corporations. Theyâre more interested in maintaining the growth than being creative.â +
++No company signifies the shift from scrappy startup to corporate establishment more than Meta, a company thatâs better known for ripping off other companiesâ ideas than producing its own. And so far, its most original innovation in years â a $10 billion bet on the metaverse â has come up mostly empty. Meanwhile, Metaâs primary strategy to keep growing has been sputtering, posing an existential threat to the company. In February 2022, for the first time in history, Facebook was losing users. Its stock plunged by 26 percent, wiping out $230 billion in market value. +
++It makes sense, then, that Zuckerberg seems to be searching for new ways to transform not only his companyâs public image but his own. During the pandemic, Zuckerberg, a self-improvement hobbyist whose wide-ranging interests include learning Mandarin and slaughtering his own meat, discovered the combat sport Brazilian jiujitsu. Immediately, he was hooked. âLike five minutes in, I was like, âWhere has this been my whole life?ââ Zuckerberg told Joe Rogan in a 2022 interview. âIt really is the best sport.â +
++Soon after taking up the new hobby, Zuckerberg was posting about it on Instagram â everything from photos at UFC games and sweaty, shirtless selfies with professional kickboxers to videos sparring on a barge to the theme of Mission Impossible. One of the most iconic images of Mark Zuckerberg following the Cambridge Analytica scandal was a photoshopped portrait on the cover of Wiredâs March 2018 issue: Zuckerberg, badly beaten, with two black eyes and a bloodied brow, his face made up in an expression of weary introspection. +
++Now, plenty of pictures of Zuckerbergâs bruised and beaten face grace his Instagram, but this time, the beatings are genuine and hard-won. âSparring got a little out of hand,â a caption reads beneath a selfie in which he is pictured with bruises beneath his eyes. +
++Zuckerbergâs infatuation with MMA has swept through Silicon Valley, too. âMMA isnât just a sport, itâs the sport,â an effusive Marc Andresseen wrote in a July 2023 newsletter entitled âFIGHTING.â The prominent venture capitalist added, âItâs important to understand how important â how primal â MMA is in the story of our civilization. MMA is the original combat sport.â +
++Zuckerbergâs interest in MMA also happened to coincide with the 2022 departure of Metaâs most public female executive, Sheryl Sandberg. For years, Sandbergâs leadership had come to signify the advent of corporate feminism, bolstered by her bestselling book, Lean In, in which she encourages women to relentlessly pursue their ambitions. But in Sandbergâs absence, Meta has become unrelenting in its own right after Zuckerberg launched his so-called âyear of efficiency.â +
++The company laid off 10,000 employees in the first few months of 2023, and its stock has rebounded. +
++Zuckerberg, in turn, has succeeded in reforming his public image. In a recent interview with the Information, Khai Wu, a professional mixed martial artist who has trained with Zuckerberg, described his impressions of the Meta CEO: âThis nerd is a silent killer.â +
++But even as tech executives flaunt their undisputed dominance, dealmaking in Silicon Valley has become increasingly cutthroat. In August, the Wall Street Journal declared: âStartups Are Dying, and Venture Investors Arenât Saving Them.â Only a few years earlier, these investors had sparked a financing hysteria so frenzied that it was compared to the dot-com boom, but now they were closely guarding their capital. Total venture spending slowed by 48 percent in the first six months of 2023. +
++Todayâs rocky market has given tech executives plenty of opportunities to flex their newly acquired muscles. Or as Kelman, Redfin CEO, puts it, âCapitalism â tooth and claw â will always come out when thereâs volatility in the market.â +
++Nowhere is this tone of ruthlessness made clearer than in the rhetoric of Elon Musk, who has spent a good part of 2023 focusing on X, formerly known as Twitter, where heâs been harassing his own employees, posting conspiracy theories, and entreating his competitors to a âliteral dick measuring contest.â +
++âElon Musk is pushing back, saying, âYou literally canât take me down,ââ said Kevin Gibbon, CEO of the e-commerce infrastructure marketplace Airhouse. âBehind closed doors, people are saying the same things that Elon Musk is saying, but heâs one of the only people who can get away with it.â +
+ ++There is the aggressive way in which Musk runs his companies, too. Cornet, the former Twitter engineer, describes it as mayhem by design. In the days following Muskâs takeover at Twitter, Cornet experienced this firsthand: Musk issued orders with urgent deadlines, threatening to fire employees who didnât meet them. In Cornetâs view, it was a matter of strategy: These impossible-to-meet deadlines ensured that employees would be incapable of questioning Muskâs decisions. The approach seems to make his companies especially difficult for women. +
++âAfter Musk hired a bunch of people it seemed like a disproportionate number of women retired,â Cornet added. âIt seemed clear that Twitter had become this really bro-ish place.â +
++This kind of abrasive management style has become the new norm in Silicon Valley. In the past year, Rajkumari Neogy, a Silicon Valley executive coach, has been asked to intervene on behalf of companies whose executives exhibit a bullish management style. +
++âIâve had to tell very senior leaders, âYou canât keep acting like this,ââ said Neogy. âItâs all about bullying, micro-managing, reprimanding â itâs always the stick and the carrot.â +
++As we enter 2024, itâs clear that Silicon Valleyâs masculinity phase is far from over. While the pendulum may eventually shift toward a climate thatâs slightly more welcoming to women and minorities, it seems unlikely that social progress will become a priority anytime soon within the tightening tech economy. +
++How activists, clinicians, and businesses are getting abortion medication to all 50 states. +
++Eighteen months after the Dobbs v. Jackson decision that overturned the constitutional right to abortion, and with a new Supreme Court challenge pending against the abortion medication mifepristone, confusion abounds about access to reproductive health care in America. +
++Since the June 2022 decision, abortion rates in states with restrictions have plummeted, and researchers estimated last month that the Dobbs decision led to âapproximately 32,000 additional annual births resulting from bans.â Journalists profiled women who carried to term since Dobbs because they couldnât afford to travel out of their restrictive state. +
++The total number of abortions in the US, however, has increased since the overturn of Roe v. Wade, driven by more people ending pregnancies in states that have laws friendly to abortion care. And often lost in this conversation is the fact that access to medication abortion has actually expanded in significant ways since the overturn of Roe v. Wade, both in terms of lower costs and avenues to obtain the pills quickly. The problem is many people who would be able to take advantage donât know about it. +
++Taking a combination of mifepristone and misoprostol within the first 12 weeks of a pregnancy was already the most common method for abortion in the United States before the Dobbs decision, partly due to its safety record, its lower cost, diminished access to in-person care, and greater opportunities for privacy. The popularity of medication abortion has only grown since then: A poll released in March found majorities of Americans support keeping medication abortion legal and allowing women to use it at home to end an early-stage pregnancy. Another survey found 59 percent of voters disapprove of overturning the FDAâs approval of abortion medication, including 72 percent of Democrats, 65 percent of independents, and 40 percent of Republicans. +
++A June report from the Society of Family Planning found abortion via telemedicine âincreased by 85 percent compared to the pre-Dobbs period, going from comprising 5 percent of all abortions to 9 percent.â And this is likely an understatement, Dana Northcraft, the founding director of Reproductive Health Initiative for Telehealth Equity and Solutions, told Vox. âThat number does not include telehealth visits by providers who also do brick-and-mortar visits, [and] it does not include self-managed abortions outside of the formal medical system,â she said. +
++Getting the word out about medication abortion has been difficult for activists, especially with headline-grabbing news stories about new efforts to restrict the pills and punish those seeking to bypass state bans. In the early months following the Dobbs decision, if you lived in a state that banned abortion, your best bet was probably ordering pills from overseas, via the reproductive health care nonprofit Aid Access, even though their shipments could take two to three weeks. +
++Today, though, providers and new organizations ship pills directly from the US to pregnant people living in more restrictive states, dramatically reducing the amount of time it takes to send the medication through the mail. International volunteer networks have also expanded to help women end their pregnancies, and campaigns to destigmatize misoprostol-only abortions, a common method used around the world, have accelerated. +
++âWeâre trying to shout this all from the rooftop,â Elisa Wells, the cofounder of Plan C, told Vox. âPeople are worried and thereâs a lot of questions out there â is this all legit? Are the pills actually going to arrive? And weâre trying to say yes, these really are real routes of access.â +
++One of the biggest expansions to access since Dobbs is via broader access to telehealth abortion care in the US, even for those living in states with bans. Telehealth abortion care means a patient can consult virtually with a provider, either on an app or in a phone call or videoconference. Following that consultation, the provider would fill a prescription for the medication, and it would be delivered via mail. +
++Efforts to expand telehealth abortion care existed prior to the overturn of Roe v. Wade. Over the objections of groups like the ACLU and the American Congress of Obstetricians and Gynecologists, the Food and Drug Administration had long barred doctors from prescribing mifepristone without an in-person health care visit first. The Biden administration eased up on this rule during the pandemic, and in December 2021 the FDA permanently lifted its restriction on telemedicine for mifepristone. (State-level restrictions on abortion telemedicine still exist.) +
++âI think Dobbs just lit a fire under the innovations that were already underway,â Kirsten Moore, the director of the Expanding Medication Abortion Access project, told Vox. â[Telemedicine] was already happening during the pandemic and then in the post-Dobbs world everyone started thinking, âOh wait, this is what weâve got to do.ââ +
++One major facilitator of expanded telemedicine is the profusion of new so-called âshield lawsâ that would protect blue-state abortion providers who send pills to people living in states where abortion is illegal. Today, six states â New York, Massachusetts, Vermont, Washington, Colorado, and California â have such telemedicine abortion shield laws, though not all have taken effect (Californiaâs wonât until January 1). Julie Kay, the co-founder of the Abortion Coalition for Telemedicine, told Vox these laws are already facilitating the distribution of pills to 6,000 patients per month in states with bans. One major advantage is that shipping pills from a US state with a shield law is much faster than shipping pills from overseas. The medication can arrive in days, rather than weeks. +
++Kay said the effort to pass shield laws was led by the medical community, not traditional pro-choice advocacy groups. âOur focus has really been on serving marginalized communities in red states that have been denied abortion, West Virginia all the way through Texas,â she said. âA lot of people living there are not able to travel but do not know they have another option.â +
++While these laws have yet to be tested in court, providers expect legal challenges eventually and have been taking steps to protect themselves, like avoiding travel to states with abortion bans in case a prosecutor tries to arrest them for violating their criminal statute. +
++Some providers living in states with shield laws are interested in stocking and shipping the medication themselves. Others say theyâd be interested if they could send prescriptions to a pharmacy that would handle the mailing for them. Starting in the new year, one online pharmacy based in California, Honeybee Health, aims to help abortion providers living in states like New York and Massachusetts serve more patients nationally. +
++âWe think people, including the media, are less familiar with the idea that you can have an abortion by mail and that the service of telehealth abortion is available in every single state â even those with bans,â said Wells, of Plan C. âThat didnât exist before Dobbs. That is the big change thatâs happened. People find it unbelievable, but itâs also fantastic.â +
++Wells says the big shift really happened in June 2023, when Aid Access became the first organization to start leveraging the new shield laws in the US. No longer would a pregnant person in Texas or Oklahoma searching for Aid Access online be routed to an abortion provider in Europe or need to wait for a pharmacist in India to mail them medication. Shortly thereafter, a new US organization, Abuzz, launched to provide telemedicine abortion to 30 states, followed in September by the Massachusetts Medication Abortion Access Project, which also utilizes shield laws for telemedicine care. +
++Outside of telemedicine options, there are over two dozen e-commerce websites that sell and ship medication abortion to the US. This international supply chain has grown significantly since Dobbs and most of these sites do not require prescriptions and do not require people to upload their IDs or have medical consultations. Plan C has vetted 26 of these sites, including testing their pills to ensure theyâre âreal products of acceptable quality.â +
++Seven of the sites Plan C has vetted offer pills for prices ranging from $42 to $47, with delivery times between two and nine days. The sites are typically selling generic medications originating from India, with the help of US-based shippers. +
++One unexpected development this year was that many of these e-commerce websites ultimately dropped their prices by hundreds of dollars, in an effort to get higher placement on Plan Câs website. +
++Another pharmaceutical provider â ProgressiveRx â provides a prescription, pills, and a telehealth consultation all for $25, though its shipments from India typically take three to four weeks to arrive. Wells says ProgressiveRx is a great option for women living in restrictive states to stock up on pills in advance. (Mifepristone has a shelf life of about five years, and misoprostol about two years.) +
++The New York Times estimated in April that international suppliers were likely to provide abortion pills to about 100,000 Americans in the year after Dobbs was decided, or âenough pills to cover about 10 percent of the countryâs annual abortions.â Anti-abortion groups have acknowledged the difficulty in stopping the flow of abortion drugs into the US. +
++Community support groups, also known as âcompanion networks,â have grown since the overturn of Roe v. Wade and now actively provide free abortion pills to people living in states with bans on reproductive health care. These groups, some of which can be found on sites like Plan C and Red State Access, mail medication abortion and offer doula support. +
++âYou communicate with these groups via [encrypted messaging apps like] Signal, and you donât need a credit card or a bank account, which can be especially important for young people who might not have those resources,â Wells said. âWe know the volunteer networks well and we have no hesitation in recommending them.â +
++Some of the volunteer companion networks are aided by activists in Mexico. The most prominent Mexican activist group is Las Libres, which was founded in 2000 to serve Mexican women. Abortion access in Mexico has improved, though, and in 2021 Las Libres pivoted to helping Texas women who were newly subject to the stateâs six-week ban. The groupâs US focus expanded further after Dobbs, and after Mexicoâs Supreme Court decriminalized abortion nationwide in September 2023. In 2022 alone, Las Libres helped terminate roughly 20,000 pregnancies in the United States. +
++Earlier this month, the US Supreme Court announced it would hear a challenge to mifepristone, the abortion medication that anti-abortion groups claim was unlawfully approved back in 2000. +
++While abortion advocates doubt the justices will go so far as to pull mifepristone off the market, as a federal judge in Texas attempted to do earlier in 2023, they are bracing for the possibility that the court might reimpose medically unnecessary restrictions on access, like bans on prescribing mifepristone via telemedicine. +
++Even if that happens, though, most of the aforementioned options for accessing medication abortion would remain intact. Itâs not clear if the FDA would even abide by such a Supreme Court ruling, but if it did, providers using shield laws could still legally ship misoprostol to patients in banned states. +
++âA Supreme Court ruling wouldnât affect the community-based networks, ProgressiveRx, or the e-commerce websites that sell pills at all, and so there would still be ways of getting mifepristone and misoprostol in the mail,â Wells said. âThe Supreme Court could affect services like Aid Access and Abuzz, but they could also switch to misoprostol-only abortions and thatâs what theyâre planning to do.â +
++While not FDA-approved, misoprostol-only abortion is a method backed by the World Health Organization, and a common way of ending pregnancies around the world. The National Abortion Federation, in its clinical guidelines, says that âwhere mifepristone is either not legally available or inaccessible, misoprostol-alone regimens may be offered.â +
++Kay, of the Abortion Coalition for Telemedicine, told Vox that some abortion providers will probably continue to ship mifepristone even if the Supreme Court reinstates the ban on mailing the pills, given that the combination of mifepristone and misoprostol is slightly more effective than misoprostol-only abortions. (Both options are considered safe for patients, but studies show using just misoprostol is effective at ending pregnancy about 88 to 93 percent of the time, versus 95 to nearly 100 percent for the two-drug regimen.) +
++A bigger threat to medication abortion access than the Supreme Court may be the election of a Republican to the White House next November, who would control appointments to key federal enforcement agencies like the Justice Department, the Department of Health and Human Services, the US Postal Service, and the FDA. +
++Anti-abortion groups have already declared medication abortion their top priority if Donald Trump or another Republican is reelected. While GOP lawmakers in Congress might not have enough votes for a federal abortion ban, activists see new executive orders as an alternative way to restrict pill distribution. Anti-abortion activists say they intend to track the views of potential GOP appointees, rather than press Republican presidential candidates on their specific regulatory plans. +
++Moore, of Expanding Medication Abortion Access, said one risk is that the government will raise the threats of criminal or financial penalties against providers, dissuading more clinicians from offering care. +
++Though the cost of medication abortion has dropped substantially since Dobbs, the price is still out of reach for some who need it, and activists are working to help more pregnant people cover the cost of their care. +
++Kay told Vox the Abortion Coalition for Telemedicine is working on a project dedicated to funding abortion pills for those who canât afford to pay, something the organization hopes to launch in early 2024. +
++Moore said leaders need to do more to support women in the two or three days after they take the abortion drugs. âMedication abortion can be an ongoing process for 24 to 48 hours, and we can get people their pills really quickly but helping them manage the process does require more time and investment,â she said. âTo be honest, I think weâre still building out the infrastructure for that part of the care.â +
++Even as activists work to expand access, anti-abortion lawmakers plan to continue their efforts to restrict access to medication abortion, including by exploring new strategies banning website visits to Aid Access and Plan C and making health care providers newly liable for disposing of aborted fetal tissue. Some lawmakers want to test the limits of their extraterritorial powers, and are exploring how they might retaliate against providers in other states, even those operating under shield laws. +
++Despite these threats, the odds of shutting down all these avenues for abortion medication is low, and the bigger challenge is really helping more people learn about their evolving options. Sometimes that means activists battling big tech platforms over what abortion-related content theyâre censoring, and sometimes it means media outlets doing a better job of conveying new information to the public. +
++Northcraft, of Reproductive Health Initiative for Telehealth Equity and Solutions, added that while telehealth can alleviate many of the expenses associated with getting an abortion â such as travel costs, taking time off work, and lining up child care â there is still more work needed to ensure equity, like ensuring that platforms and providers communicate in multiple languages. +
++âAt the end of the day medication abortion is safe, effective, and what people want,â Kay said. âAnd itâs going to be available by licensed medical professionals, by people who are mission-driven but not medically certified, or through a for-profit thing on the world wide web. We know itâs not going away.â +
Shamrock, Fast Pace, Fondness Of You, River Of Gold, Siege Courageous and Bharat shine -
The Protector and Itâs My Time impress -
Indian Olympic Association forms three-member ad hoc committee to run affairs of suspended WFI - The Sports Ministry had suspended the WFI, three days after it elected new office bearers with Brij Bhushan Singh loyalist Sanjay Singh as president
Suriya joins list of celebrity owners of Indian Street Premier League 2024; ISPL announces actor as owner of Team Chennai - Suriya joins Amitabh Bachchan, Akshay Kumar, Hrithik Roshan, and Ram Charan who own the Mumbai, Srinagar, Bengaluru and Hyderabad teams respectively
Djokovic wants to emulate Brady and play on into his 40s - âTom Brady is a great example of a champion in his sport and someone that has had such a great career and longevity,â says Novak Djokovic.
GMIT Davangere students win Smart India Hackathon - Final-year Computer Science and Engineering students of GM Institute of Technology (GMIT), Davanagere, won the national-level Smart India Hackathon held at Rajam in Andhra Pradesh
MG University joins hands with Kazakhstan university - Mahatma Gandhi University Vice-Chancellor C. T. Aravindakumar held consultations with M. Auezov South Kazakhstan University officials
Poonch ambush: Security forces initiate fresh searches along IB, LOC - Mobile internet services will remain suspended in Rajouri and Poonch for the fifth day in a row.
FIR against BJP MP Pratap Simmha in Mysuru - Mysuru district Congress Committee president B.J. Vijayakumar alleged that Mr Simmha had not only spoken derisively about the Chief Minister, but had also, without any basis, accused Mr Siddaramaiah of pitting one caste against another
Telangana | Stage set for the launch of Praja Palana aimed at taking governance to the doorstep of people - Praja Palana to be held between Dec 28 and Jan 6 in all villages and wards across the State
Wolfgang SchĂ€uble: Merkelâs no-nonsense finance minister dies aged 81 - Although never chancellor, Wolfgang SchĂ€uble was one of Germanyâs most influential politicians.
Russia confirms damage to warship in Black Sea - The Ministry of Defence says the ship was struck by Ukrainian aircraft carrying guided missiles.
Alexei Navalny: âDonât worry about me!â Putin critic says from Arctic prison - The Russian opposition leader was missing for weeks while being moved to one of Russiaâs toughest jails.
Pint-sized bottles of wine to be sold after Brexit review - The new 568ml size will offer more choice for customers, the Department for Business and Trade says.
Spanish-Moroccan letters of forbidden love that were never received - Confiscated messages written to Moroccan men by Spanish women reveal a history of taboo affairs.
Researchers argue back and forth about whether weâve spotted an exomoon - Years after Kepler shut down, people are arguing over whether it spotted exomoons. - link
No last-minute reprieve, US ban on some Apple Watch sales now in effect - Watch Series 9 and Watch Ultra 2 blood oxygen sensors are patent-infringing. - link
Watch sand defy gravity and flow uphill thanks to ânegative frictionâ - Applying magnetic forces to single iron oxide-coated particles spurs strange collective motion. - link
Elon Musk will see you in court: The top Twitter and X Corp. lawsuits of 2023 - Muskâs Twitter ownership began with a lawsuit, and heâs been in court ever since. - link
Science lives here: take a virtual tour of the Royal Institution in London - No less than 14 Nobel laureates have conducted ground-breaking research at the Institution. - link
My wife finished a 36-week bodybuilding program yesterday. -
++We welcomed a baby girl into our family weighing 8 pounds and 2 ounces. +
++Iâm officially a father! +
+ submitted by /u/DibyanLonelyNibba
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A man named Edward Gay booked a flight to visit his mother for Christmas. -
++When he entered the airplane he noticed a man took his seat. Deciding he didnât want to make a scene and that the plane was going to be half empty anyway, he decided to take a random empty seat at the back of the plane. +
++A few minutes later a flight attendant approached the man that took his seat. âHello, are you Gay?â asked the flight attendant. âWhy yes I amâ, the man confusedly replied. âIâm sorryâ, said the flight attendant, âThereâs been a misunderstanding. You will have to leave this plane.â +
++Edward Gay realized the flight attendant was talking about him. He stood up and said, âNo, Iâm Gay!â. Another passenger immediately stood up and shouted, âThatâs right! Iâm gay too! You canât kick us all out!â. +
+ submitted by /u/bobbdac7894
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A young newlywed couple wanted to join a church⊠-
++A young newlywed couple wanted to join a church. The pastor told them, âWe have special requirements for new parishioners. You must abstain from having sex for two weeks.â The couple agreed and came back at the end of two weeks. The pastor asked them, âWell, were you able to get through the two weeks without being intimate?â +
++âPastor, Iâm afraid we were not able to go without sex for the two weeks,â the young man replied. âWhat happened?â inquired the pastor. âMy wife was reaching for a can of corn on the top shelf and dropped it. When she bent over to pick it up, I was overcome with lust and took advantage of her right there.â âYou understand, of course, that this means you will not be welcome in our church,â stated the pastor. âThatâs okay,â said the young man. âWeâre not welcome at the grocery store anymore either.â +
+ submitted by /u/Jolly_Bit8480
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Me: Iâm stuck on this clue. Whatâs a seven letter word for evident? -
++Her: Itâs obvious. +
++Me: That may be, but I have no clue what it is. +
+ submitted by /u/porichoygupto
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One day, little Johnny overheard his parents fighting⊠-
++One day, Little Johnny overheard his parents fighting. Later, he asked what âbitchâ and âbastardâ mean. They explained that they mean âladyâ and âgentleman.â The next day, he overheard his parents having sex. He later asked what âpenisâ and âvaginaâ mean. His parents explained that they refer to âhatsâ and âcoats.â At supper the next day, Little Johnnyâs mom cut her finger in the kitchen and yelled,âOh fuck!â Little Johnny asked what that meant, and she said it means âcut.â A week later, guests arrive for Thanksgiving dinner. Little Johnny welcomes them at the door, saying, âHello bitches and bastards! Hurry up with your penises and vaginas â we canât wait to fuck the turkey!â +
+ submitted by /u/Jolly_Bit8480
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