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<title>23 March, 2021</title>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>On the use of ‘glyphmaps’ for analysing Covid-19 reported cases</strong> -
<div>
Recent analysis of area-level Covid-19 cases data attempts to grapple with a challenge familiar to geovisualization: how to capture the development of the virus, whilst supporting analysis across geographic areas? We present several glyphmap designs for addressing this challenge applied to local authority data in England whereby charts displaying multiple aspects related to the pandemic are given a geographic arrangement. These graphics are visually complex, with clutter, occlusion and salience bias an inevitable consequence. We develop a framework for systematically describing and validating the graphics against data and design requirements. Through an observational data analysis, we then relate designs to particular data analysis needs based on the usefulness of the structure they expose. Our designs, documented in an accompanying code repository, attend to common difficulties in geovisualization design and could transfer to contexts outside of the UK and to phenomena beyond the pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/6nz8q/" target="_blank">On the use of ‘glyphmaps’ for analysing Covid-19 reported cases</a>
</div></li>
<li><strong>Replicative fitness SARS-CoV-2 20I/501Y.V1 variant in a human reconstituted bronchial epithelium</strong> -
<div>
Since its emergence in 2019, circulating populations of the new coronavirus continuously acquired genetic diversity. At the end of 2020, a variant named 20I/501Y.V1 (lineage B.1.1.7) emerged and replaced other circulating strains in several regions. This phenomenon has been poorly associated to biological evidence that this variant and original strain exhibit different phenotypic characteristics. Here, we analyse the replication ability of this new variant in different cellular models using for comparison an ancestral D614G European strain (lineage B1). Results from comparative replication kinetics experiments in vitro and in a human reconstituted bronchial epithelium showed no difference. However, when both viruses were put in competition in a human reconstituted bronchial epithelium, the 20I/501Y.V1 variant outcompeted the ancestral strain. Altogether, these findings demonstrate that this new variant replicates more efficiently and could contribute to better understand the progressive replacement of circulating strains by the SARS-CoV-2 20I/501Y.V1 variant.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.436427v1" target="_blank">Replicative fitness SARS-CoV-2 20I/501Y.V1 variant in a human reconstituted bronchial epithelium</a>
</div></li>
<li><strong>Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2</strong> -
<div>
The recent emergence of SARS-CoV-2 variants with increased transmission, pathogenesis and immune resistance has jeopardised the global response to the COVID-19 pandemic. Determining the fundamental biology of viral variants and understanding their evolutionary trajectories will guide current mitigation measures, future genetic surveillance and vaccination strategies. Here we examine virus entry by the B.1.1.7 lineage, commonly referred to as the UK/Kent variant. Pseudovirus infection of model cell lines demonstrate that B.1.1.7 entry is enhanced relative to the Wuhan-Hu-1 reference strain, particularly under low expression of receptor ACE2. Moreover, the entry characteristics of B.1.1.7 were distinct from that of its predecessor strain containing the D614G mutation. These data suggest evolutionary tuning of spike protein function. Additionally, we found that amino acid deletions within the N-terminal domain (NTD) of spike were important for efficient entry by B.1.1.7. The NTD is a hotspot of diversity across sarbecoviruses, therefore, we further investigated this region by examining the entry of closely related CoVs. Surprisingly, Pangolin CoV spike entry was 50-100 fold enhanced relative to SARS-CoV-2; suggesting there may be evolutionary pathways by which SARS-CoV-2 may further optimise entry. Swapping the NTD between Pangolin CoV and SARS-CoV-2 demonstrates that changes in this region alone have the capacity to enhance virus entry. Thus, the NTD plays a hitherto unrecognised role in modulating spike activity, warranting further investigation and surveillance of NTD mutations.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.436468v1" target="_blank">Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2</a>
</div></li>
<li><strong>Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals</strong> -
<div>
The rapid development and deployment of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals. While a two-dose immunization regimen with the BNT162b2 vaccine has been demonstrated to provide a 95% efficacy in naive individuals, the effects of the second vaccine dose in individuals who have previously recovered from natural SARS-CoV-2 infection has been questioned. Here we characterized SARS-CoV-2 spike-specific humoral and cellular immunity in naive and previously infected individuals during full BNT162b2 vaccination. Our results demonstrate that the second dose increases both the humoral and cellular immunity in naive individuals. On the contrary, the second BNT162b2 vaccine dose results in a reduction of cellular immunity in COVID-19 recovered individuals, which suggests that a second dose, according to the current standard regimen of vaccination, may be not necessary in individuals previously infected with SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.436441v1" target="_blank">Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity in naive and COVID-19 recovered individuals</a>
</div></li>
<li><strong>TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform</strong> -
<div>
The COVID-19 pandemic has highlighted the need for new antiviral targets, as many of the currently approved drugs have proven ineffective against mitigating SARS-CoV-2 infections. The host transmembrane serine protease TMPRSS2 is a highly promising antiviral target, as it plays a direct role in priming the spike protein before viral entry occurs. Further, unlike other targets such as ACE2, TMPRSS2 has no known biological role. Here we utilize virtual screening to curate large libraries into a focused collection of potential inhibitors. Optimization of a recombinant expression and purification protocol for the TMPRSS2 peptidase domain facilitates subsequent biochemical screening and characterization of selected compounds from the curated collection in a kinetic assay. In doing so, we demonstrate that serine protease inhibitors camostat, nafamostat, and gabexate inhibit through a covalent mechanism. We further identify new non-covalent compounds as TMPRSS2 protease inhibitors, demonstrating the utility of a combined virtual and experimental screening campaign in rapid drug discovery efforts.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.436465v1" target="_blank">TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform</a>
</div></li>
<li><strong>Structural modeling of the SARS-CoV-2 Spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibility</strong> -
<div>
The COVID-19 pandemic has triggered concerns about the emergence of more infectious and pathogenic viral strains. As a public health measure, efficient screening methods are needed to determine the functional effects of new sequence variants. Here we show that structural modeling of SARS-CoV-2 Spike protein binding to the human ACE2 receptor, the first step in host-cell entry, predicts many novel variant combinations with enhanced binding affinities. By focusing on natural variants at the Spike-hACE2 interface and assessing over 700 mutant complexes, our analysis reveals that high-affinity Spike mutations (including N440K, S443A, G476S, E484R, G502P) tend to cluster near known human ACE2 recognition sites (K31 and K353). These Spike regions are conformationally flexible, allowing certain mutations to optimize interface interaction energies. Although most human ACE2 variants tend to weaken binding affinity, they can interact with Spike mutations to generate high-affinity double mutant complexes, suggesting variation in individual susceptibility to infection. Applying structural analysis to highly transmissible variants, we find that circulating point mutations S447N, E484K and N501Y form high-affinity complexes (~40% more than wild-type). By combining predicted affinities and available antibody escape data, we show that fast-spreading viral variants exploit combinatorial mutations possessing both enhanced affinity and antibody resistance, including S447N/E484K, E484K/N501Y and K417T/E484K/N501Y. Thus, three-dimensional modeling of the Spike/hACE2 complex predicts changes in structure and binding affinity that correlate with transmissibility and therefore can help inform future intervention strategies.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.436454v1" target="_blank">Structural modeling of the SARS-CoV-2 Spike/human ACE2 complex interface can identify high-affinity variants associated with increased transmissibility</a>
</div></li>
<li><strong>Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy</strong> -
<div>
Neutralizing antibodies (NAbs) are effective in treating COVID-19 but the mechanism of immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment in prophylaxis and therapy of K18-hACE2 mice intranasally infected with SARS-CoV-2-nanoluciferase. We visualized sequential spread of virus from the nasal cavity to the lungs followed by systemic spread to various organs including the brain, culminating in death. Highly potent NAbs from a COVID-19 convalescent subject prevented, and also effectively resolved, established infection when administered within three days of infection. In addition to direct neutralization, in vivo efficacy required Fc effector functions of NAbs, with contributions from monocytes, neutrophils and natural killer cells, to dampen inflammatory responses and limit immunopathology. Thus, our study highlights the requirement of both Fab and Fc effector functions for an optimal in vivo efficacy afforded by NAbs against SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.436337v1" target="_blank">Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy</a>
</div></li>
<li><strong>Predicting hosts based on early SARS-CoV-2 samples and analyzing later world-wide pandemic in 2020</strong> -
<div>
The SARS-CoV-2 pandemic has raised the concern for identifying hosts of the virus since the early-stage outbreak. To address this problem, we proposed a deep learning method, DeepHoF, based on extracting the viral genomic features automatically, to predict host likelihood scores on five host types, including plant, germ, invertebrate, non-human vertebrate and human, for novel viruses. DeepHoF made up for the lack of an accurate tool applicable to any novel virus and overcame the limitation of the sequence similarity-based methods, reaching a satisfactory AUC of 0.987 on the five-classification. Additionally, to fill the gap in the efficient inference of host species for SARS-CoV-2 using existed tools, we conducted a deep analysis on the host likelihood profile calculated by DeepHoF. Using the isolates sequenced in the earliest stage of COVID-19, we inferred minks, bats, dogs and cats were potential hosts of SARS-CoV-2, while minks might be one of the most noteworthy hosts. Several genes of SARS-CoV-2 demonstrated their significance in determining the host range. Furthermore, the large-scale genome analysis, based on DeepHoF’s computation for the later world-wide pandemic in 2020, disclosed the uniformity of host range among SARS-CoV-2 samples and the strong association of SARS-CoV-2 between humans and minks.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.21.436312v1" target="_blank">Predicting hosts based on early SARS-CoV-2 samples and analyzing later world-wide pandemic in 2020</a>
</div></li>
<li><strong>An mRNA vaccine against SARS-CoV-2: Lyophilized, liposome-based vaccine candidate EG-COVID induces high levels of virus neutralizing antibodies</strong> -
<div>
In addition to the traditional method of vaccine development, the mRNA coronavirus vaccine, which is attractive as a challenging vaccination, recently opened a new era in vaccinology. Here we describe the EG-COVID which is a novel liposome-based mRNA candidate vaccine that encodes the spike (S) protein of SARS-CoV-2 with 2P-3Q substitution in European variant. We developed the mRNA vaccine platform that can be lyophilized using liposome-based technology. Intramuscular injection of the EG-COVID elicited robust humoral and cellular immune response to SARS-CoV-2. Furthermore, sera obtained from mice successfully inhibited SARS-CoV-2 viral infection into Vero cells. We developed EG-COVID and found it to be effective based on in vitro data, and we plan to initiate a clinical trial soon. Since EG-COVID is a lyophilized mRNA vaccine that is convenient for transportation and storage, accessibility to vaccines will be significantly improved.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.436375v1" target="_blank">An mRNA vaccine against SARS-CoV-2: Lyophilized, liposome-based vaccine candidate EG-COVID induces high levels of virus neutralizing antibodies</a>
</div></li>
<li><strong>Protease-activatable biosensors of SARS-CoV-2 infection for cell-based drug, neutralisation and virological assays</strong> -
<div>
The world is in the grip of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, and there is an urgent unmet clinical need for effective antiviral therapies. Many inhibitors of viral enzymes identified in vitro have limited efficacy against viral replication in cells, but conventional plaque assays are impractical for high-throughput screens. In this study, we therefore engineer cell-based biosensors of SARS-CoV-2 infection. Our assays exploit the cleavage of specific oligopeptide linkers by SARS-CoV-2 Main or Papain-like proteases, leading to the activation of green fluorescent protein (GFP) or firefly luciferase-based reporters. First, we characterise these biosensors in cells using recombinant viral proteases. Next, we confirm their ability to detect endogenous viral protease expression during infection with wildtype SARS-CoV-2. Finally, we develop a sensitive luminescent reporter cell line, confirm that it accurately quantitates infectious SARS-CoV-2 virus, and demonstrate its utility for drug screening and titration of neutralising antibodies.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.435957v1" target="_blank">Protease-activatable biosensors of SARS-CoV-2 infection for cell-based drug, neutralisation and virological assays</a>
</div></li>
<li><strong>CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2</strong> -
<div>
The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic necessitates the fast development of vaccines as the primary control option. Recently, viral mutants termed “variants of concern” (VOC) have emerged with the potential to escape host immunity. VOC B.1.351 was first discovered in South Africa in late 2020, and causes global concern due to poor neutralization with propensity to evade preexisting immunity from ancestral strains. We tested the efficacy of a spike encoding mRNA vaccine (CVnCoV) against the ancestral strain BavPat1 and the novel VOC B.1.351 in a K18-hACE2 transgenic mouse model. Naive mice and mice immunized with formalin-inactivated SARS-CoV-2 preparation were used as controls. mRNA-immunized mice developed elevated SARS-CoV-2 RBD-specific antibody as well as neutralization titers against the ancestral strain BavPat1. Neutralization titers against VOC B.1.351 were readily detectable but significantly reduced compared to BavPat1. VOC B.1.351-infected control animals experienced a delayed course of disease, yet nearly all SARS-CoV-2 challenged naive mice succumbed with virus dissemination and high viral loads. CVnCoV vaccine completely protected the animals from disease and mortality caused by either viral strain. Moreover, SARS-CoV-2 was not detected in oral swabs, lung, or brain in these groups. Only partial protection was observed in mice receiving the formalin-inactivated virus preparation. Despite lower neutralizing antibody titers compared to the ancestral strain BavPat1, CVnCoV shows complete disease protection against the novel VOC B.1.351 in our studies.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.22.435960v1" target="_blank">CVnCoV protects human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2</a>
</div></li>
<li><strong>Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment</strong> -
<div>
Background: Dementia-like cognitive impairment is an increasingly reported complication of SARS-CoV-2 infection. However, the underlying mechanisms responsible for this complication remain unclear. A better understanding of causative processes by which COVID-19 may lead to cognitive impairment is essential for developing preventive interventions. Methods: In this study, we conducted a network-based, multimodal genomics comparison of COVID-19 and neurologic complications. We constructed the SARS-CoV-2 virus-host interactome from protein-protein interaction assay and CRISPR-Cas9 based genetic assay results, and compared network-based relationships therein with those of known neurological manifestations using network proximity measures. We also investigated the transcriptomic profiles (including single-cell/nuclei RNA-sequencing) of Alzheimer disease (AD) marker genes from patients infected with COVID-19, as well as the prevalence of SARS-CoV-2 entry factors in the brains of AD patients not infected with SARS-CoV-2. Results: We found significant network-based relationships between COVID-19 and neuroinflammation and brain microvascular injury pathways and processes which are implicated in AD. We also detected aberrant expression of AD biomarkers in the cerebrospinal fluid and blood of patients with COVID-19. While transcriptomic analyses showed relatively low expression of SARS-CoV-2 entry factors in human brain, neuroinflammatory changes were pronounced. In addition, single-nucleus transcriptomic analyses showed that expression of SARS-CoV-2 host factors (BSG and FURIN) and antiviral defense genes (LY6E, IFITM2, IFITM3, and IFNAR1) was significantly elevated in brain endothelial cells of AD patients and healthy controls relative to neurons and other cell types, suggesting a possible role for brain microvascular injury in COVID-19-mediated cognitive impairment. Notably, individuals with the AD risk allele APOE E4/E4 displayed reduced levels of antiviral defense genes compared to APOE E3/E3 individuals. Conclusion: Our results suggest significant mechanistic overlap between AD and COVID-19, strongly centered on neuroinflammation and microvascular injury. These results help improve our understanding of COVID-19-associated neurological manifestations and provide guidance for future development of preventive or treatment interventions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.15.435423v1" target="_blank">Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment</a>
</div></li>
<li><strong>Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism</strong> -
<div>
The spread of SARS-CoV-2 and the increasing mortality rates of COVID-19 create an urgent need for treatments, which are currently lacking. Although vaccines have been approved by the FDA for emergency use in the U.S., patients will continue to require pharmacologic intervention to reduce morbidity and mortality as vaccine availability remains limited. The rise of new variants makes the development of therapeutic strategies even more crucial to combat the current pandemic and future outbreaks. Evidence from several studies suggests the host immune response to SARS-CoV-2 infection plays a critical role in disease pathogenesis. Consequently, host immune factors are becoming more recognized as potential biomarkers and therapeutic targets for COVID-19. To develop therapeutic strategies to combat current and future coronavirus outbreaks, understanding how the coronavirus hijacks the host immune system during and after the infection is crucial. In this study, we investigated immunological patterns or characteristics of the host immune response to SARS-CoV-2 infection that may contribute to the disease severity of COVID-19 patients. We analyzed large bulk RNASeq and single cell RNAseq data from COVID-19 patient samples to immunoprofile differentially expressed gene sets and analyzed pathways to identify human host protein targets. We observed an immunological profile of severe COVID-19 patients characterized by upregulated cytokines, interferon-induced proteins, and pronounced T cell lymphopenia, supporting findings by previous studies. We identified a number of host immune targets including PERK, PKR, TNF, NF-kB, and other key genes that modulate the significant pathways and genes identified in COVID-19 patients. Finally, we identified genes modulated by COVID-19 infection that are implicated in oncogenesis, including E2F transcription factors and RB1, suggesting a mechanism by which SARS-CoV-2 infection may contribute to oncogenesis. Further clinical investigation of these targets may lead to bonafide therapeutic strategies to treat the current COVID-19 pandemic and protect against future outbreaks and viral escape variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.02.17.431721v2" target="_blank">Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism</a>
</div></li>
<li><strong>Evolution and spread of SARS-CoV-2 likely to be affected by climate</strong> -
<div>
COVID-19 pandemic has been extensively studied by many researchers. However, it is still unclear why it was restricted to higher latitudes during the initial days and later cascaded in the tropics. Here, we analyzed 176 SARS-CoV-2 genomes across different latitudes and climate (Koppen climate) that provided insights about within species virus evolution and its relation to abiotic factors. Two genetically variant groups, named as G1 and G2 were identified, well defined by four mutations. The G1 group (ancestor), is mainly restricted to warm and moist, temperate climate (Koppen C climate) while its descendent G2 group surpasses the climatic restrictions of G1, initially cascading into neighboring cold climate (D) of higher latitudes and later into hot climate of the tropics (A). It appears that the gradation of temperate climate (Cfa-Cfb) to cold climate (Dfa-Dfb) drives the evolution of G1 into G2 variant group which later adapted to tropical climate (A) as well. It seems this virus followed inverse latitudinal gradient in the beginning due to its preference towards temperate (C) and cold climate (D). Our work elucidates virus evolutionary studies combined with climatic studies can provide crucial information about the pathogenesis and natural spreading pathways in such outbreaks which is hard to achieve through individual studies. Mutational insights gained may help design an efficacious vaccine.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.06.18.147074v3" target="_blank">Evolution and spread of SARS-CoV-2 likely to be affected by climate</a>
</div></li>
<li><strong>Show me the study! Science by press release is not science</strong> -
<div>
In this brief communication, the authors develop the argument that science by press release and by press conference without the readily available study for scrutiny is outside of the ethos of the scientific enterprise. Additionally, we argue why and how science by press conference and by press release is a recipe for misinformation and poor choices in public health decision-making fitting into the scope of your respectable journal. Finally, the authors dive into the implications of this emerging phenomenon for public health in Brazil in the COVID19 era.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/metaarxiv/tk8w9/" target="_blank">Show me the study! Science by press release is not science</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pilot Trial of XFBD, a TCM, in Persons With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Xuanfei Baidu Granules;   Other: Placebo<br/><b>Sponsor</b>:   Darcy Spicer<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Tolerability of Emricasan in Symptomatic Outpatients Diagnosed With Mild-COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Emricasan;   Other: Placebo<br/><b>Sponsor</b>:   Histogen<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Reinforcing Standard Therapy in COVID-19 Patients With Repeated Transfusion of Convalescent Plasma</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Convalescent Plasma with antibody against SARS-CoV-2.;   Other: Standard treatment for COVID-19<br/><b>Sponsors</b>:   Hospital Son Llatzer;   Fundació d’investigació Sanitària de les Illes Balears<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ANTIcoagulation in Severe COVID-19 Patients</strong> - <b>Condition</b>:   Severe COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: Tinzaparin, Low dose prophylactic anticoagulation;   Drug: Tinzaparin, High dose prophylactic anticoagulation;   Drug: Tinzaparin,Therapeutic anticoagulation<br/><b>Sponsor</b>:   Assistance Publique - Hôpitaux de Paris<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neuromodulation in COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Device: Transcranial direct-current stimulation;   Device: Sham Transcranial direct-current stimulation<br/><b>Sponsors</b>:   D’Or Institute for Research and Education;   Rio de Janeiro State Research Supporting Foundation (FAPERJ);   Conselho Nacional de Desenvolvimento Científico e Tecnológico;   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Off-the-shelf NK Cells (KDS-1000) as Immunotherapy for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: KDS-1000;   Other: Placebo<br/><b>Sponsor</b>:   Kiadis Pharma<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Corticosteroids for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Prednisone;   Device: Point of Care testing device for C-reactive protein<br/><b>Sponsor</b>:   University of Alberta<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Telerehabilitation After Discharge in COVID-19 Survivors</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Telerehabilitation<br/><b>Sponsor</b>:   Hacettepe University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Assess if a Medicine Called Bamlanivimab is Safe and Effective in Reducing Hospitalization Due to COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Bamlanivimab;   Other: Standard of Care<br/><b>Sponsors</b>:   Fraser Health;   Fraser Health Authrority Department of Evaluation and Research Services;   Surrey Memorial Hospital Clinical Research Unit;   Centre for Health Evaluation and Outcome Sciences;   Surrey Hospitals Foundation;   BC Support Unit;   University of British Columbia;   Ministry of Health, British Columbia<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Adaptogens in Patients With Long COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Dietary Supplement: ADAPT-232 oral solution;   Other: Placebo oral solution<br/><b>Sponsors</b>:   Swedish Herbal Institute AB;   National Family Medicine Training Centre, Georgia;   Tbilisi State Medical University;   Phytomed AB<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Self-Testing Through Rapid Network Distribution</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Behavioral: COVID-19 self-test;   Behavioral: COVID-19 test referral<br/><b>Sponsors</b>:   University of Pennsylvania;   Public Health Management Corporation<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effectiveness of the Adsorbed Vaccine COVID-19 (Coronavac) Among Education and Public Safety Workers With Risk Factors for Severity</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: Adsorbed SARS-CoV-2 (inactivated) vaccine<br/><b>Sponsors</b>:   Fundação de Medicina Tropical Dr. Heitor Vieira Dourado;   Butantan Institute<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Text-based Reminders to Promote COVID-19 Vaccinations</strong> - <b>Condition</b>:   Covid19, Vaccines<br/><b>Interventions</b>:   Behavioral: Self-benefit;   Behavioral: Prosocial-benefit;   Behavioral: Early access;   Behavioral: Fresh start<br/><b>Sponsors</b>:   University of California, Los Angeles;   Carnegie Mellon University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Text-based Interventions to Promote COVID-19 Vaccinations</strong> - <b>Condition</b>:   Covid19, Vaccines<br/><b>Interventions</b>:   Behavioral: Patient MyChart Scheduling Link;   Behavioral: Patient Educational Video;   Behavioral: Enhanced Follow through Message<br/><b>Sponsors</b>:   University of California, Los Angeles;   Carnegie Mellon University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of Psidii Guava’s Extract For COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Extract Psidii guava;   Combination Product: Standard therapy for Covid-19 patient<br/><b>Sponsor</b>:   Faculty of Medicine Baiturrahmah University<br/><b>Completed</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in mice</strong> - More than 65 million people have been confirmed infection with SARS-CoV-2 and more than 1 million have died from COVID-19 and this pandemic remains critical worldwide. Effective vaccines are one of the most important strategies to limit the pandemic. Here, we report a construction strategy of DNA vaccine candidates expressing full length wild type SARS-CoV-2 spike (S) protein, S1 or S2 region and their immunogenicity in mice. All DNA vaccine constructs of pCMVkan-S, -S1 and -S2 induced high…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2</strong> - Up to date, effective antivirals have not been widely available for treating COVID-19. In this study, we identify a dual-functional cross-linking peptide 8P9R which can inhibit the two entry pathways (endocytic pathway and TMPRSS2-mediated surface pathway) of SARS-CoV-2 in cells. The endosomal acidification inhibitors (8P9R and chloroquine) can synergistically enhance the activity of arbidol, a spike-ACE2 fusion inhibitor, against SARS-CoV-2 and SARS-CoV in cells. In vivo studies indicate that…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the safety and efficacy of XAV-19 in patients with COVID-19-induced moderate pneumonia: study protocol for a randomized, double-blinded, placebo-controlled phase 2 (2a and 2b) trial</strong> - BACKGROUND: Early inhibition of entry and replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a very promising therapeutic approach. Polyclonal neutralizing antibodies offers many advantages such as providing immediate immunity, consequently blunting an early pro-inflammatory pathogenic endogenous antibody response and lack of drug-drug interactions. By providing immediate immunity and inhibiting entry into cells, neutralizing antibody treatment is of interest for…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A small molecule compound berberine as an orally active therapeutic candidate against COVID-19 and SARS: A computational and mechanistic study</strong> - The novel coronavirus disease, COVID-19, has grown into a global pandemic and a major public health threat since its breakout in December 2019. To date, no specific therapeutic drug or vaccine for treating COVID-19 and SARS has been FDA approved. Previous studies suggest that berberine, an isoquinoline alkaloid, has shown various biological activities that may help against COVID-19 and SARS, including antiviral, anti-allergy and inflammation, hepatoprotection against drug- and infection-induced…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon</strong> - World population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>On the search for COVID-19 therapeutics: identification of potential SARS-CoV-2 main protease inhibitors by virtual screening, pharmacophore modeling and molecular dynamics</strong> - COVID-19 also known as SARS-CoV-2 outbreak in late 2019 and its worldwide pandemic spread has taken the world by surprise. The minute-to-minute increasing coronavirus cases (&gt;85 M) and progressive deaths (≈1.8 M) calls for finding a cure to this devastating pandemic. While there have been many attempts to find biologically active molecules targeting SARS-CoV-2 for treatment of this viral infection, none has found a way to the clinic yet. In this study, a 3-feature structure-based pharmacophore…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phylogenic analysis of coronavirus genome and molecular studies on potential anti-COVID-19 agents from selected FDA-approved drugs</strong> - The emergence of 2019 novel Coronavirus (COVID-19 or 2019-nCoV) has caused significant global morbidity and mortality with no consensus specific treatment. We tested the hypothesis that FDA-approved antiretrovirals, antibiotics, and antimalarials will effectively inhibit COVID-19 two major drug targets, coronavirus nucleocapsid protein (NP) and hemagglutinin-esterase (HE). To test this hypothesis, we carried out a phylogenic analysis of coronavirus genome to understand the origins of NP and HE,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential of CRISPR/Cas13 System in Treatment and Diagnosis of COVID-19</strong> - The novel coronavirus disease 2019 (COVID-19) belongs to coronaviridae families like sarbecovirus (SARS), and causes pyrexia, pertussis, and acute respiratory distress syndrome (ARDS) in major. Started from Wuhan, China, COVID-19 now forced the World Health Organization (WHO) call it a global pandemic. These dreadful figures elevate the need for rapid action for a rapid diagnostic tool, an efficacious therapy, or vaccine for such widespread disease. In this article, we reviewed all the latest…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of flavonoids as 2019-nCoV cell entry inhibitor through molecular docking and pharmacological analysis</strong> - The outbreak of Coronavirus Disease 2019 (COVID-19) has been declared as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), which is being rapidly spread by the extremely spreadable and pathogenic 2019 novel coronavirus (2019-nCoV), also known as SARS-CoV-2. Pandemic incidence of COVID-19 has created a severe threat to global public health, necessitating the development of effective drugs or inhibitors or therapeutics agents against SARS-CoV-2….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comprehensive analysis of SARS-CoV-2 antibody dynamics in New Zealand</strong> - CONCLUSION: Antibodies to SARS-CoV-2 persist for up to 8 months following mild-to-moderate infection. This robust response can be attributed to the initial exposure without immune boosting given the lack of community transmission in our setting.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RGD-binding integrins and TGF-beta in SARS-CoV-2 infections - novel targets to treat COVID-19 patients?</strong> - The new coronavirus SARS-CoV-2 is a global pandemic and a severe public health crisis. SARS-CoV-2 is highly contagious and shows high mortality rates, especially in elderly and patients with pre-existing medical conditions. At the current stage, no effective drugs are available to treat these patients. In this review, we analyse the rationale of targeting RGD-binding integrins to potentially inhibit viral cell infection and to block TGF-β activation, which is involved in the severity of several…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2</strong> - Acid preconditioning (APC) through carbon dioxide inhalation can exert protective effects during acute lung injury (ALI) triggered by ischemia-reperfusion. Angiotensin-converting enzyme 2 (ACE2) has been identified as a receptor for severe acute respiratory syndrome coronavirus and the novel coronavirus disease-19. Downregulation of ACE2 plays an important role in the pathogenesis of severe lung failure after viral or bacterial infections. The aim of the present study was to examine the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Molecular Mechanism of Action of Repurposed Drugs and Traditional Chinese Medicine Used for the Treatment of Patients Infected With COVID-19: A Systematic Scoping Review</strong> - Background: The emergence of COVID-19 as a pandemic has resulted in the need for urgent development of vaccines and drugs and the conduction of clinical trials to fight the outbreak. Because of the time constraints associated with the development of vaccines and effective drugs, drug repurposing and other alternative treatment methods have been used to treat patients that have been infected by the SARS-CoV-2 virus and have acquired COVID-19. Objective: The objective of this systematic scoping…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A review on function and side effects of systemic corticosteroids used in high-grade COVID-19 to prevent cytokine storms</strong> - In December 2019, a cluster of pneumonia caused by a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, Hubei province, China. Cytokine storm is an uncontrolled systemic inflammatory response resulting from the release of large amounts of pro-inflammatory cytokines and chemokines that occurs at phase 3 of viral infection. Such emergence led to the development of many clinical trials to discover efficient drugs and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A comprehensive insight into the role of zinc deficiency in the renin-angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients</strong> - Hypozincemia is prevalent in severe acute respiratory syndrome coronavirus-2 (SARS-COV-2)-infected patients and has been considered as a risk factor in severe coronavirus disease-2019 (COVID-19). Whereas zinc might affect SARS-COV-2 replication and cell entry, the link between zinc deficiency and COVID-19 severity could also be attributed to the effects of COVID-19 on the body metabolism and immune response. Zinc deficiency is more prevalent in the elderly and patients with underlying chronic…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Peptides and their use in diagnosis of SARS-CoV-2 infection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU319943278">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A PROCESS FOR SUCCESSFUL MANAGEMENT OF COVID 19 POSITIVE PATIENTS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU319942709">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sars-CoV-2 vaccine antigens</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318283136">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-COV-2 BINDING PROTEINS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318004130">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bildschirmgerät mit verbesserter Wirkung bei der Befestigung von UV-Entkeimungslampen</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Ein Bildschirmgerät mit verbesserter Wirkung bei der Befestigung von UV-Entkeimungslampen, umfassend: ein Bildschirmgerät, das einen Umfang hat; eine UV-Entkeimungslampe, die sich am Umfang des Bildschirmgeräts befindet; eine Stromquelle, die elektrisch mit der UV-Entkeimungslampe verbunden ist; eine Steuerschaltung, die elektrisch mit der UV-Entkeimungslampe verbunden ist; und eine Befestigungsvorrichtung, durch die die UV-Entkeimungslampe am Umfang des Bildschirmgeräts befestigbar ist, wobei die Befestigungsvorrichtung einen Sitzkörper, eine erste Klemmplatte und eine zweite Klemmplatte aufweist, wobei der Sitzkörper mit der UV-Entkeimungslampe versehen ist, wobei die erste Klemmplatte und die zweite Klemmplatte beabstandet am Sitzkörper gleitbar angeordnet sind, wodurch ein Klemmabstand zwischen der ersten Klemmplatte und der zweiten Klemmplatte besteht, wobei ein elastisches Element zwischen der zweiten Klemmplatte und dem Sitzkörper angeordnet ist, um die zweite Klemmplatte dazu zu zwingen, sich der ersten Klemmplatte zu nähern.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE320246402">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Schublade mit antiepidemischer Wirkung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Schublade mit antiepidemischer Wirkung, mit einem Schrank (1); mindestens einer Schublade (2), die in dem Schrank (1) angeordnet ist, wobei jede Schublade (2) einen Schubladenraum (25) aufweist; einer UV-Sterilisationsvorrichtung (3), die an der Schublade (2) angeordnet ist; einer Stromquelle (4), die elektrisch mit der UV-Sterilisationsvorrichtung (3) verbunden ist; einer Steuerschaltung (5), die elektrisch mit der Stromquelle (4) und der UV-Sterilisationsvorrichtung (3) verbunden ist; und einem Sensor (6), der elektrisch mit der Steuerschaltung (5) verbunden ist.</p></li>
</ul>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE320246401">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gerät zur Unterstützung und Verstärkung natürlicher Lüftung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Lüftungssystem für einen mit öffnbaren Fenstern (16) ausgestatteten Gebäuderaum, gekennzeichnet dadurch, dass es ein Gehäuse (18) und einen Ventilator (20) aufweist, wobei durch das Gehäuse eine vom Ventilator erzeugte Luftströmung strömen kann, wobei das Gehäuse dafür eine Einströmöffnung (24) für Luft und eine Ausströmöffnung (22) für Luft enthält, wobei eine der beiden Öffnungen der Form eines Öffnungsspalts (26) zwischen einem Fensterflügel (12) und einem Blendrahmen (14) des Fensters (16) angepasst ist.</p></li>
</ul>
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<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE319927546">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>X射线图像识别方法、装置、计算机设备及存储介质</strong> - 本申请涉及一种X射线图像识别方法、装置、计算机设备和存储介质。通过获取X射线图像，将X射线图像作为训练样本；构建多注意力交互网络，多注意力交互网络包括卷积批处理标准化网络、特征提取网络和输出网络；其中特征提取网络包括多注意力交互特征提取模块和批标准化模块，特征提取网络通过学习通道之间的相关性，多通道之间的信息交互来达到增强模型的识别能力。利用训练样本对多注意力交互网络进行训练，得到X射线图像识别模型；获取待测X射线图像；将待测X射线图像输入到X射线图像识别模型中，得到X射线图像的类别。本方法减少了网络的参数量和计算量，提高了模型的泛化能力。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN319953046">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法</strong> - 本发明提供一种利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法，包括：1）构建新冠病毒核衣壳蛋白（N蛋白）重组表达载体；2）用重组表达载体转染HEK293细胞；3）体外培养细胞，从培养上清中分离纯化N蛋白。利用HEK293表达系统可在短时间内获得大量新冠病毒N蛋白，通过一步亲和层析法可获得纯度高达98%以上的N蛋白。与大肠杆菌相比，采用HEK293表达系统制备的N蛋白在与抗体的结合活性及新冠抗体胶体金检测方面均表现出极大优势，且HEK293表达系统制备的N蛋白其蛋白空间构象接近于病毒N基因在宿主体内的蛋白表达构象，具有更高的免疫诊断和抗体制备的准确性，将其用于制作诊断试剂和疫苗前景广阔。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN319953048">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for detecting SARS-CoV-2 spike protein</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU317343760">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Garland Is the Last, Best Chance to Uncover Trump’s Role on January 6th</strong> - The ongoing federal criminal inquiry is the most promising route to the truth. - <a href="https://www.newyorker.com/news/daily-comment/garland-is-the-last-best-chance-to-uncover-trumps-role-on-january-6th">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Atlanta Shooting and the Dehumanizing of Asian Women</strong> - To live through this period as an Asian-American is to feel trapped in an American tragedy while being denied the legitimacy of being an American. - <a href="https://www.newyorker.com/news/daily-comment/the-atlanta-shooting-and-the-dehumanizing-of-asian-women">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The High Cost of Georgia’s Restrictive Voting Bills</strong> - Racist policies are bad for business, as the state’s own history can attest. - <a href="https://www.newyorker.com/magazine/2021/03/29/the-high-cost-of-georgias-restrictive-voting-bills">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Biden Rattled Putin</strong> - All it seems to take is to say something that’s true. - <a href="https://www.newyorker.com/news/our-columnists/how-joe-biden-rattled-vladimir-putin">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Reeducated</strong> - A virtual-reality documentary takes viewers inside Xinjiang’s secret detention camps for Uighurs and other predominantly Muslim minorities. - <a href="https://www.newyorker.com/news/video-dept/reeducated-film-xinjiang-prisoners-china-virtual-reality">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“The clock is ticking”: Battling cancer while the world is on pause</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/i3kZG5mJRqeO-xbzROtCqgpSZP4=/440x0:7512x5304/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69010889/GettyImages_1242485859.0.jpeg"/>
<figcaption>
For those battling cancer during the pandemic, time lost during the worldwide shutdown felt particularly acute. | FG Trade/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“I don’t know how much time I get.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x5hC4T">
Justine Luebke, a 32-year-old teacher who lives in Montana, was undergoing chemotherapy for metastatic cancer when the pandemic hit last year. As the world shut down, Luebke was figuring out what she wanted the rest of her life to look like. “Time takes on a new meaning when you go through this,” she said. “This pandemic has definitely felt like it’s taken time from me. And I don’t know how much time I get.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3be04X">
There is no cure for metastatic cancer. Treatment options are available, but once diagnosed, it is generally understood that patients will be sick for the rest of their lives. The median survival range for people with the disease is three years, but that can vary wildly depending on factors like age and treatment. It is common among those who are diagnosed to experience an urgent shift in their priorities — some want to travel the world, or stay close to family, or pursue meaningful fulfillment in their professional enterprises. Unfortunately, all of those considerations are sidelined by a pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nzemAC">
As vaccinations ramp up, the country is taking on a newfound optimism and a sense that the end of the worst of this pandemic is fast approaching. For many, the past year will represent only a blip in their lifespan. But the same blessing does not apply to those battling cancer. They aren’t guaranteed anything, other than the weekslong intervals between check-ins with their doctors. They never know what news the next scan might bring. This pandemic has been cruelly unfair for so many different reasons, but especially for those who don’t know how much time they have left — and will never get lost time back.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VFUDbQ">
We reached out to three women, all in their 30s, about what it’s been like to endure the Covid-19 pandemic while having metastatic cancer. Some of them are raising kids, some are still going to work, and all of them feel like the pandemic has stolen a precious year away from them. When you’re sick, all you want to do is hug your friends. Read their stories below.
</p>
<h3 id="IUuOE3">
“One thing I wasn’t willing to give up is teaching … My kids are my biggest reason for fighting.”
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4uE6fj">
<strong>Justine Luebke, 32, Montana</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iyC9cB">
In 2019 I was diagnosed with rectal cancer. I went through five weeks of chemo, and then waited for my surgery. It went terribly wrong. I ended up losing all of my large intestines, most of my small, and was in the ICU for a month. By the time I was strong enough to do the cleanup chemo, they had found that the cancer had spread to my liver and my lungs. So, in August of that year, I had confirmed metastatic cancer. I was doing chemo all the way up to April 2020.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ahHWdH">
Covid felt like a domino effect. It was a Saturday night in March, and my family called me and said that I needed to consider going fully into quarantine. I’m a teacher, so that would’ve meant not teaching. I went to the grocery store and stocked up, and told my school that I shouldn’t be going in. But after that weekend, everything shut down anyway. When I was going through these treatments, I’d have my parents at every appointment with me. Every doctor’s appointment, every scan, they were present. And now they couldn’t be there. That was extremely tough, especially on chemo days.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jTnqiV">
I still get to see my parents outside of the appointments. Fighting cancer is as mental as it is physical, and if I didn’t see my parents I’d go to a pretty dark place. My mom works from home. My dad goes into work but is very careful. I’m now fully vaccinated, so that helps a ton, too. I’m able to see friends who are also vaccinated.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1hDqyc">
One thing I wasn’t willing to give up is teaching. I’ve been teaching in person all year, and I try to create a bubble in my classroom. My kids are my biggest reason for fighting. I don’t have kids of my own, and I will not be able to have kids of my own. So, my students are like my kids. The fifth graders I teach are the same students I had in kindergarten. When they run up to me and give me a hug, that’s when I’m like, “Okay, that’s why you have to keep fighting, because you’re not going to leave these kids.” When I come to school, I leave what I’m dealing with at the door and I can be there for them. They give me meaning beyond cancer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nteH7W">
Time takes on a new meaning when you go through this. They almost lost me when I was in the ER. After that, the moments you spend with your friends and your family are so precious. We’ve all tried to find connections during quarantine. We can Zoom with our friends. But you just want to be having dinner in their house together. This pandemic has definitely felt like it’s taken time from me. And I don’t know how much time I get.
</p>
<h3 id="uVAD7k">
“When you’re dealing with full-time treatment, it makes you want to go out into the world and travel and experience all of these things.”
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UZgUQQ">
<strong>Emily Veach, 39, Illinois</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K63LV0">
Covid has been stressful and scary, but I also felt like I had a bit of a head start on these feelings of uncertainty, and the perception of threat in my environment. A lot more people have gotten to know the things that I worry about already. My idea of normalcy was stripped away a long time ago.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w1qf1w">
I was originally diagnosed in 2014 with early-stage breast cancer. It has since spread to my bones, and became late-stage breast cancer in 2017. My treatment weakens my immune system. I’ve had fevers that have landed me in the hospital, so I’ve always been aware of that even before the pandemic — long before 2020, I was flying with a mask on. Now, I no longer have to put up with any weird stares about wearing a mask.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xWmgMa">
I was making plans to move to Illinois before the pandemic started. When the lockdowns occurred, I knew that’s what I still wanted to do, and I went through all the scenarios to figure out what was the safest way. My wonderful mother volunteered to drive out and get me. I rented an SUV and packed everything in there, to the point that it felt like a big camping trip. I made the journey alone, and made stops along the way. My favorite was in Cedar Crest, New Mexico. I knew someone through my network who runs a nonprofit that does adventure trips for cancer survivors. I wanted to spend this trip outside of anyone’s home, and he invited me to camp in his place. It was up in the mountains, he hooked me up with a portable heater, and I spent the night in his horse barn. It was beautiful.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IVsitV">
The things that have become most important in my life are nature and my community. But I haven’t seen my dad in a long time. I haven’t seen my best friends. We can jump on video calls, but I really want to hug my friends. When you’re dealing with full-time treatment, it makes you want to go out into the world and travel and experience all of these things. There’s a time sensitivity about that to me.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MRMaOk">
I have scans every 12 weeks. You never know which scan is going to be a really big change in your life. While I have this stability, I want to be out doing all I can.
</p>
<h3 id="NTgC6j">
“I want [my kids] to look back and say, ‘Mama really tried to do these things before she was gone.’”
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fMZ7mH">
<strong>Erin Schellert, 37, Missouri</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="y8ML9R">
I was diagnosed with metastatic breast cancer in May of 2019. I was 36 years old, and my two kids turned 2 and 4 within a month of my diagnosis. I went in to see a doctor for an unrelated issue, and through some imaging they found a mass on my breast. It went downhill from there. Breast cancer wasn’t even on my radar, and then I learned it was in my brain, my lungs, and my bones. You’re in treatment indefinitely with my cancer. I live my life in three-month increments.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BeYIwd">
Currently I’m doing really well. If I was walking down the street you’d have no idea what was going on with me. That whole summer, two years ago, felt like it was stolen from us. I was thinking about all the fun things we could do as a family, and now here I was sick from chemo and hairless. 2020 was supposed to be the year we made up for lost time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZsG9g8">
I heard bits and pieces about Covid in the news in the first few months of last year. I can’t remember the exact date, but there was definitely a moment where it felt like the bottom fell out. I saw the writing on the wall that things were about to close down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1sxlYI">
We obviously couldn’t travel last summer, but we were able to get together with some people who had kids between the ages of 1 through 5. My husband was doing all the shopping, which was a big adjustment for us. It was manageable, but as the year progressed, we definitely got more scared. My mother used to visit quite a bit to give me a break and let me rest for a little bit. With nobody comfortable with flying, she didn’t come as often. Before the pandemic, we wanted to hire someone to come to the house and take care of the kids — but we could never find a situation we were comfortable with. That was hard, because I do get tired. Little kids are exhausting.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jz4fEu">
You never know, but it’s pretty likely that my lifespan will be shortened and that my kids won’t have their whole life with their mama. There’s so many things I want to do with them and want to experience together. This should’ve been my daughter’s first year of kindergarten. There’s years of school I’m probably not going to be here for, and we didn’t end up sending her because we were nervous about exposure. We’ve done a good job of making memories this last year, but one thing I really want to do is see all 50 states with my kids. I got them little state passports, and we’re gonna fill them all out. We need to get started on that. The clock is ticking. I want them to look back and say, “Mama really tried to do these things before she was gone.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KXqI3z">
The first thing we’re going to do when we get a green light is a road trip. My husband and I used to love road trips before we had children. I want to put the kids in the car and have a destination in mind, but no route. We’re not big planners. We just want to see where things take us.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JH12xx">
</p></li>
<li><strong>10 ways office work will never be the same</strong> -
<figure>
<img alt="People sit at a long conference table, each with their own laptop in front of them." src="https://cdn.vox-cdn.com/thumbor/BgakJ8Tv_NZp_fRRg9lmK1a9qLE=/0x0:2667x2000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69010835/GettyImages_1268536478.0.jpg"/>
<figcaption>
One of the many conference rooms at the then-startup Gusto, in San Francisco in 2018. | Michael Macor/San Francisco Chronicle via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
From where we work to how our work is measured, office work will be permanently different after the pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y41jqU">
Someday, perhaps someday soon, when vaccination rates are high enough and the <a href="https://www.vox.com/coronavirus-covid19">coronavirus</a> relents, the world will return to normal. But in its wake, something as massive and meaningful as a global pandemic will leave many things different, including how we work.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yQdjfU">
In particular, knowledge workers — high-skilled workers whose jobs are done on computers — will likely see the biggest changes, from our physical locations to the technology we use to the ways in which our productivity is measured. In turn, how we work impacts everything from our own personal satisfaction to new inventions to the broader economy and society as a whole.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="k1W965">
These changes represent a chance to remake work as we know it and to learn from the mistakes of our working past — if we’re thoughtful about how we enact them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yFoKdW">
Here are 10 ways in which office work will never be the same.
</p>
<h3 id="dQitay">
<ol type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Working from home is here to stay
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HF6K9d">
Even after the pandemic is no longer forcing us to work from home, many people will continue to do so. That’s because working from home has worked surprisingly well for both employers and employees. People were productive and employers saw a future in which they were less tethered to expensive office real estate. And, going forward, many of the things that aren’t working — having to homeschool while working, for example, or feeling like work never ends because you never leave your house — will be alleviated when we’re not in the middle of a global health crisis that’s adding extra hurdles and stress to working from home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UjotRN">
“One of the few great upsides of the pandemic is we’ve accelerated 25 years of drift toward working from home in one year,” <a href="https://www.vox.com/2020/3/20/21187469/work-from-home-coronavirus-productivity-mental-health-nicholas-bloom">Nicholas Bloom</a>, a Stanford University professor who studies remote work, told Recode.
</p>
<div class="c-wide-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/lMs2NoPHyf9OwL8Vxgewnc8KitQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22383775/GettyImages_958967578.jpg"/> <cite>Eduardo Munoz Alvarez/Getty Images</cite>
<figcaption>
Commuters wait for train service to be restored after a severe thunderstorm in New York’s Grand Central Terminal in 2018.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2M2idM">
At the height of the pandemic, more than half of the US workforce worked from home, up from the single digits previously, <a href="https://www.vox.com/recode/21727016/2020-in-charts-covid-vaccine-pandemic-election">according to market research company IDC</a>. When the pandemic is over, those who can work from home will likely do so two or three days a week, according to research by <a href="https://nbloom.people.stanford.edu/sites/g/files/sbiybj4746/f/wfh_will_stick_v5.pdf">Bloom and his co-authors</a> that surveyed worker desires as well as their boss’s promises. This so-called hybrid work model, in which some workers work from home some of the time, will be the dominant office job arrangement. A smaller share of workers — 15 to 18 percent — will be remote full time, according to estimates from business consulting firm <a href="http://www.emergentresearch.com/">Emergent Research</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PciGoI">
And there are measurable benefits to working from home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u7BgHb">
Working from home allows people to skip their commute and can give them more flexibility in the hours they work, an arrangement workers are on board with and willing to put a dollar sign on. Bloom’s data says employees are willing to take an 8 percent pay cut for the opportunity to work from home two or three days a week. Remote employees save an average of $248 a month, according to a <a href="https://www.owllabs.com/state-of-remote-work/2020">survey by Owl Labs and Global Workplace Analytics</a>. Office management software company <a href="https://envoy.com/blog/envoy-survey-finds-employees-want-companies-to-embrace-hybrid-work-and-mandate-covid-vaccines/">Envoy found</a> that nearly half of employees said they’d leave their job if it didn’t offer a hybrid work model after the pandemic.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ylPN6x">
In short, the ability to work from home is no longer a perk; not allowing it is a dealbreaker.
</p>
<h3 id="wPOtgj">
<ol start="2" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Flexibility is a double-edged sword
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="izGL8N">
For years, workers have clamored for more flexibility in their work to accommodate their lives. And working from home will give them that.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Mtuvxa">
“A lot of our employees said, ‘I’m getting more sleep,’ ‘I’m exercising more,’ ‘I’m making myself healthier food,’ ‘I know my neighbors more,’” said Ali Rayl, Slack’s VP of customer experience. “And people are really digging that kind of getting back to their lives.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1qWg59">
The flip side to all this flexibility is an increased feeling that work never ends: People are logging longer hours, attending more meetings, and complaining of just generally being always on. It’s tough to find work-life balance when the lines between the two are blurred.
</p>
<div class="c-float-right c-float-hang">
<aside id="Cwexza">
<q>54 percent of people feel overworked and 39 percent say they feel exhausted</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rSHmWg">
Time spent in meetings is more than double what it was early last year, according to a <a href="https://click.linksynergy.com/deeplink?id=nOD%2FrLJHOac&amp;mid=24542&amp;u1=vox&amp;murl=https%3A%2F%2Fwww.microsoft.com%2Fen-us%2Fworklab%2Fwork-trend-index%2Fhybrid-work" rel="sponsored nofollow noopener" target="_blank">new report from Microsoft’s Work Trend Index</a>, which combines insights from people using its tools like Microsoft 365 as well as a survey of more than 30,000 workers. Working from home requires more context than people would grasp naturally in an office, and people have created more meetings to fill the void.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mamXum">
People spend an additional hour — for a total of 10 hours — connected to Slack than they did pre-pandemic. The amount of time people spend actively working in or communicating on Slack jumped 30 percent to 110 minutes a day, according to the company. That means more time with Slack in the background and the foreground of our lives.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e4KnWN">
All of this can hamper productivity and generally leave people feeling worn out. Microsoft’s January survey found that 54 percent feel overworked and 39 percent say they feel exhausted.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2PzVpx">
Jared Spataro, corporate VP for Microsoft 365, considers this an “opportunity” for leadership to improve the experience at work. “If you just go with the flow and let the default reign, you’ll end up in a worse place than pre-pandemic,” he said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e38Pbx">
Jan Rezab, founder and CEO of productivity analytics firm <a href="https://www.timeisltd.com/">Time Is Ltd.</a>, agrees that a lot of our worst habits in the office — interruptions that keep us from focusing, meetings for the sake of meetings — have been carried over to remote work. “We’re just as unproductive as we were before,” he said.
</p>
<h3 id="kcbEqd">
<ol start="3" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Some populations will benefit from working from home while others struggle
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6iUn5Z">
The benefits of working from home will not be evenly felt. While some groups have enjoyed working from home, the arrangement has been challenging for others.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L5eNZU">
First of all, only some jobs accord workers the ability to work from home in the first place, and that has largely been divided by income and education. People who work in high-skilled jobs that require a bachelor’s degree or higher were more likely to be able to work from home during the pandemic, according to <a href="https://www.pewresearch.org/social-trends/2020/12/09/how-the-coronavirus-outbreak-has-and-hasnt-changed-the-way-americans-work/">surveys from Pew Research Center</a>. In turn, people with lower-paying jobs were more likely to be in danger of contracting Covid-19 at work. The divide between those who can and can’t work from home will likely persist after the pandemic, creating what Stanford’s Bloom called a “two-tier economy” of who gets to enjoy work-from-home benefits and who doesn’t.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6XGZnh">
Many presumed young people, who are more familiar with technologies like video calls, would have had an easier time with the transition to working from home than their older and less tech-savvy peers, but multiple studies say that hasn’t been the case.
</p>
<div class="c-float-right c-float-hang">
<aside id="CbUcr0">
<q>“We’re just as unproductive as we were before”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ThktW7">
Employees over the age of 40 were more likely to say they would prefer to continue working remotely, while employees younger than 40 were more likely to want to return to the office, according to one study <a href="https://www.bucknell.edu/sites/default/files/college_of_management/covid-19_telework_study_report.pdf">of teleworkers done by Bucknell University</a>. Young people felt they were missing out on the mentorship and soft skills they would have received working alongside older colleagues in the office, who can help them advance their careers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aMjAGq">
“They are impatient to be successful,” Eddy Ng, a professor at Bucknell University and one of the report’s authors, told Recode. “They now know the value of social capital and the need to interact with others.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NdSZaO">
Meanwhile, more senior employees as well as managers — many of whom had been skeptical of remote work pre-pandemic — are more likely to prefer working from home. About 60 percent of business leaders said they are “thriving,” according to Microsoft’s Work Trend Index, while a similar percentage of Gen Z workers are only “surviving,” or struggling with well-being and mental health.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0HuSuU">
There are a bunch of reasons for the age divide.
</p>
<div class="c-wide-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/HMV4Cq0Ob4IoWsMCNI4r9LKoSBM=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22383786/GettyImages_1268536392.jpg"/> <cite>Michael Macor/San Francisco Chronicle via Getty Images</cite>
<figcaption>
Following the last recession, companies have been packing more and more people into open office spaces, a practice known as “densification.”
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f7XZR1">
Work-from-home software proved surprisingly effective and simple for people of all ages, with 80 percent of employees in the Bucknell survey reporting that they had an easy time figuring out and using their company information and communication technology (think Zoom, Slack, Teams). Managers reported fewer distractions — namely, their underlings interrupting them at the office. Additionally, older employees are more secure in their careers. They are also more likely to have nicer, bigger, and more private home arrangements than younger people, who often have to contend with roommates or young children at home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="n3y0UF">
Indeed, half of parents with children under 18 said it was difficult to get work done without interruptions, compared with just 20 percent for people without kids at home, <a href="https://www.pewresearch.org/social-trends/2020/12/09/how-the-coronavirus-outbreak-has-and-hasnt-changed-the-way-americans-work/">according to Pew</a>. Women, who <a href="https://www.vox.com/22321909/covid-19-pandemic-school-work-parents-remote">shoulder outsized responsibility for child care</a> in addition to their jobs, have a more difficult relationship to working from home. They are much more likely to report <a href="https://www.vox.com/22060380/covid-parents-burnout-schools-closed-kids-pandemic">burnout</a> than men and have been increasingly <a href="https://www.vox.com/policy-and-politics/22264320/jobs-report-unemployment-rate-inequality">leaving the workforce altogether</a>, though women are also more likely than men to want to continue working from home post-pandemic. Of course, a lot of these troubles might be alleviated once the pandemic is over and other aspects of life — and child care — go back to normal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lqRxox">
A Slack study showed that race also affects people’s experience of working from home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DRP0ej">
Nearly all Black knowledge workers currently working from home, some 97 percent, want a hybrid or fully remote work model, compared with 79 percent of their white counterparts, <a href="https://futureforum.com/2021/03/11/dismantling-the-office-moving-from-retrofit-to-redesign/">according to data from Slack’s Future Forum survey</a>. The report posited a number of reasons, including remote work reducing the need for “code switching,” or making oneself and one’s speech fit the norms of a majority white office. Being outside the office also reduced instances of microaggressions and discrimination and improved Black employees’ ability to recover from those incidents. With remote work, Black knowledge workers reported a greater sense of belonging, a greater ability to manage work stress, and greater work-life balance than their white colleagues.
</p>
<h3 id="L35QWT">
<ol start="4" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">The office will still exist, but you’ll use it differently
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WRIDM3">
While many companies are downsizing their office footprints, most. are not getting rid of offices. Indeed, the office will still play an important — though different — role in people’s work.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3vk9FJ">
More time in the office will be geared toward collaborative work that’s more challenging at home. Employers are also eager to revive the serendipity and problem-solving a physical office engenders — think of running into a colleague from a different department in the break room and getting her outside perspective on a task that’s tripping you up.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BlmoQ1">
“We’re starting to think about the office as a tool in our toolkit for getting certain kinds of work done,” Slack’s Rayl said. “Folks come into the office a couple times a week, they have plans with colleagues to get together and brainstorm and plan collaboration in person.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GyXbuI">
And to accommodate this type of work, the office itself will need a bit of a makeover.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hQTkzL">
Kate Lister, president of future of work consulting firm <a href="https://globalworkplaceanalytics.com/">Global Workplace Analytics</a>, expects more emphasis on shared spaces, which would be a flip from the previous configuration of the office space. Instead of offices that have typically had 80 percent personal space and 20 percent shared space, she said, 80 percent of the space going forward will be collaborative, while only 20 percent will be earmarked for people’s own use.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0bIfl8">
To aid the reconfiguration, some companies will replace people’s personal desks with “hot desks,” or space that any employee can use for private work when they’re in the office.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L5S15Z">
These trends in total are also a <a href="https://www.vox.com/recode/22193428/wework-flexible-coworking-office-space-pandemic">surprising boon for coworking companies like WeWork and Industrious</a>. Even companies that are forgoing their own office space altogether are likely to pay for flexible office space for those times in which they do in fact need an office.
</p>
<aside id="a3XogF">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P8QMoY">
Technology in the office will also need a bit of a reboot, to accommodate meetings so that people videoconferencing in from home feel on equal footing with those in the office. This will require better video hardware and software so that at-home workers don’t feel like they’re just a box on a screen.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hC75ev">
A whole cottage industry has popped up to <a href="https://www.nytimes.com/2021/02/17/magazine/video-conference.html">make remote communication more like real-life interactions</a> — or at least less soul-crushing than a day of Zoom calls. This ranges from cameras that follow you around the room to software that makes virtual venues more lifelike or immersive.
</p>
<h3 id="lFm8WS">
<ol start="5" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Expect more AI, automation, and freelancers
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BQZvkJ">
Thanks to layoffs during the pandemic, many companies will have to operate with a leaner workforce than before. In turn, the remaining workers will have to rely more heavily on technology, fast-tracking existing trends toward artificial intelligence, automation and contract work.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kXgHUJ">
“The introduction or acceleration of these tools should allow us to be able to handle the volume of business without having to do a lot of hiring until the economy is really booming again,” Kate Duchene, CEO of consulting firm Resources Global Professionals (RGP), told Recode.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3vyQod">
Indeed, every time there’s an economic downturn there’s a <a href="https://www.vox.com/recode/2020/3/31/21200010/coronavirus-recession-automation-brookings-mark-muro">push toward automation</a>, since it cuts down on the very expensive cost of human labor.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qZQHnD">
“There’s little doubt that there’s been more automation this year, as financial stress coincided with better applications, and health and social distance concerns to create more demand,” Mark Muro, senior fellow and policy director at the Brookings Institution’s Metropolitan Policy Program, told Recode. He stressed that automation is not sequestered to blue-collar workers, but that <a href="https://www.brookings.edu/research/what-jobs-are-affected-by-ai-better-paid-better-educated-workers-face-the-most-exposure/">office jobs are particularly in danger of automation</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0krWrd">
Companies hoping to be more agile are also likely to outsource more work to contract and freelance workers, who they have to pay less since they’re short-term and don’t get as many benefits as employees.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XkeLFM">
“Companies said it last recession, and they’re really saying it this recession,” explained Steve King, partner at Emergent Research. “Everybody’s telling us that … we’re going to increase our use of external talent or non-employee labor.”
</p>
<div class="c-float-right">
<aside id="BzUso2">
<q>For those of us left with jobs, we can take solace in the fact that our work might be less tedious</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MoIcZl">
He added, “Once you’ve made the decision to integrate someone in remotely, whether they’re a traditional employee or not, it’s not as big a leap to then say, ‘Oh, we can hire a contractor to do that work.’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ji6v4o">
For those of us left with jobs, we can take solace in the fact that our work might be less tedious.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jFRDGP">
Wayne Kurtzman, research director at IDC, expects workplace software to incorporate a lot more artificial intelligence and machine learning in the next five years that will help knowledge workers do their jobs with less drudgery.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="70UkAu">
“So many of us, when we work, such a big percentage is in menial tasks and not the actual valuable work,” he said. “What if we were able to automate a portion of menial tasks and spend more time on meaningful work?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TYqPDx">
With more artificial intelligence and automation, “More barriers to work getting done will be removed so work can be done quicker, more intelligently, and possibly even more creatively.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QReRIJ">
For instance, workplace software like Zoom and Teams already lets people transcribe meetings. What if future versions trimmed those meetings down to shorter videos or text that would be most germane to you?
</p>
<h3 id="vuV7Ob">
<ol start="6" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Our communication will be more asynchronous
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sncW2f">
As we move more toward a hybrid work model, don’t expect your colleagues to get back to you right away. While in an office, you can walk right up to your boss or coworker to ask a question. The creators of workplace software are hoping to make things a little different online. Specifically, to enable a remote workforce that might be scattered around the globe, they’re hoping to replace a lot of synchronous communication (in-person chats, live video, phone calls) with conversations that can happen at people’s leisure (messages, posts, recorded video).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="95x95q">
The intention is to allow people to better concentrate than they could in the office, and to accommodate the realities of working from home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ROdDe1">
“The companies that have navigated this the best are the ones that have figured out what’s urgent and how can we plan to make sure that fewer things are urgent,” Slack’s Rayl said. Doing so enables workers, especially parents, to make room for their lives at home, including teaching their kids or bringing them to school. “The expectation that everyone’s on all the time and everyone responds instantly is deeply unhealthy and it’s not equitable.”
</p>
<div class="c-wide-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/WYv75mfOI4kBCBxjIT3GfozOu1M=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22383799/GettyImages_1208924338.jpg"/> <cite>Keri Wiginton/Tribune News Service via Getty Images</cite>
<figcaption>
An open office layout at Coyote Logistics in Chicago, Illinois, in 2016.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sp7U67">
As it stands, Time Is Ltd.’s Rezab says that most employees use existing communications software like Slack and Teams in a way that’s very synchronous. When people message their colleagues, they expect a quick response and they usually get it, which can be deleterious for concentration.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xUxV6w">
“Most of the current users of tools like Slack, Microsoft Teams, and others, treat it as synchronous communication,” Rezab said. “And I think — personal opinion — that’s wrong.” For communication to be truly asynchronous, the software will have to be better at managing people’s expectations.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qbrO6H">
Slack has been adding a number of subtle tweaks to goad people toward asynchronous communication, like putting up do not disturb notifications if people connect their calendars and are in a meeting. The company is also working on a feature that would allow asynchronous video recording so that people can add video comments to a conversation about a prototype, for example, without all having to gather in an hour-long meeting to do so.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kUzfCS">
Smaller workplace software companies like <a href="https://www.volleyapp.com">Volley</a> and <a href="https://friday.app">Friday</a> are creating platforms that are meant to be inherently asynchronous, with features like pre-recorded video and allocated time for catching up.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="68xzK6">
It will also be important for companies themselves to govern how people use their workplace communications software and what’s expected of them and their response times. The vast majority of communications on Slack and Teams happen through direct messages, which many people feel compelled to respond to more quickly than, say, a post in a channel. To make sure this doesn’t feel just as pressing as a tap on the shoulder, companies need to institute guidelines that assure workers a response isn’t immediately necessary.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BLxZFo">
Unfortunately, since many companies moved to remote work so swiftly at the onset of the pandemic, they didn’t have time to put into place best practices for communicating online and working from home, Lister, from Global Workplace Analytics, said. Just because things are working okay doesn’t mean they can’t be made better.
</p>
<h3 id="f5KMG3">
<ol start="7" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">How our productivity is measured will change
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EHKRVn">
One long-held criticism of the physical office is that metrics, like how long you spent there, mattered to management, and this assumption cultivated a system that benefited, say, young men without families, who could log more hours. Now, without as much emphasis on the actual office, the way that managers measure an employee’s success will also change.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xuf8VG">
RGP’s Duchene said the emphasis for knowledge workers has moved to output, or how much work an employee actually does.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2irpCi">
“When I think about two years ago, how did you evaluate people in a workplace setting, it was aptitude, attitude, and attendance,” Duchene said. “Now that you don’t have those things on a daily basis, the concentration is on output.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JoFgIS">
IDC’s Kurtzman thinks productivity metrics will be more qualitative: the outcome of production rather than the raw amount of something produced. He argued, “How much you can produce is an assembly-line metric, but doesn’t tell me how happy the customer is and if the customer will buy from you again.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9UtPF0">
As definitions of productivity stand, the majority of workers <a href="https://nbloom.people.stanford.edu/sites/g/files/sbiybj4746/f/wfh_will_stick_v5.pdf">in</a> <a href="https://www.bucknell.edu/sites/default/files/college_of_management/covid-19_telework_study_report.pdf">multiple</a> <a href="https://resources.owllabs.com/state-of-remote-work/2020">studies</a> <a href="https://click.linksynergy.com/deeplink?id=nOD%2FrLJHOac&amp;mid=24542&amp;u1=vox&amp;murl=https%3A%2F%2Fwww.microsoft.com%2Fen-us%2Fworklab%2Fwork-trend-index%2Fhybrid-work" rel="sponsored nofollow noopener" target="_blank">say</a> they’re just as <a href="https://learnmore.monster.com/community-insights-during-coronavirus">productive</a> or even <a href="https://hbr.org/2020/08/research-knowledge-workers-are-more-productive-from-home">more productive</a> at home as they were at the office. Duchene, however, cautioned against solely looking at productivity, since that could cause other parts of work — like culture — to suffer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cjd1KV">
“You can’t make that your priority and ignore everything else,” Duchene said.
</p>
<h3 id="WeA9Qe">
<ol start="8" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Culture will be harder to create
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LItsgu">
It’s much harder to make and retain a company culture when workers aren’t in the same room. And that ability has diminished as the pandemic has worn on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="owZC1L">
“I wasn’t worried at the beginning of Covid about keeping the culture alive — we were all reaching out, everyone was so concerned about community,” said RGP’s Duchene. “Then we got in a rhythm of ‘this is here to stay’ so there’s not as much energy.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q3uxkH">
In turn, workers have been limiting their interactions to a more core group of people — the ones they work with directly — rather than communicating with a wider range of groups that they may have in the office. And judging from onboarding metrics during the pandemic, that shift is primed to continue. The number of connections new hires make at work — inferred by time spent in small meetings and in the number of direct communications with different people — is down 17 percent compared with pre-pandemic, according to data from Time Is Ltd. 
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GOWTqj">
“It’s been a good thing for productivity, a bad thing for culture,” Duchene said.
</p>
<div class="c-wide-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/ATUANXf5ayOgzbx9Lo2BJ-0yLLk=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22383847/GettyImages_1206475791.jpg"/> <cite>David L. Ryan/The Boston Globe via Getty Images</cite>
<figcaption>
Empty desks at the Fuze office in Boston, Massachusetts, on March 10, 2020.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s1O9wd">
Without interactions with a wide range of people at your company, company culture suffers since people aren’t exposed to the same set of behaviors and values.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lT1mKR">
There have been some unexpected consequences as well. It’s notable, for example, that being physically separate from management has led to a <a href="https://www.bloomberg.com/news/articles/2021-01-12/whistle-blowing-soars-to-record-with-americans-working-from-home">spike in people reporting their employers</a> for white-collar malfeasance. And the lack of cultural cohesion has implications for how the business operates.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PqSlLc">
“This will create silos in the business, massive silos,” Time Is Ltd.’s Rezab said, which can contribute to groupthink and can hinder progress. “The company gets things done by collaborating cross-functionally,” Rezab said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8l80qE">
To rectify this, management will have to be more intentional with connecting people across the organization, rather than just their direct colleagues. So far it’s been difficult to mimic online the culture-building that happens in person.
</p>
<h3 id="oqYzlI">
<ol start="9" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">We’re more human at work
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nFnRtr">
You don’t come out of seeing your coworkers — and their living rooms and their babies and their pets — in the middle of a global pandemic without getting a little closer to them. And such closeness makes people happier and better at work.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d3U7qy">
The pandemic did a good job of humanizing people, not only because we saw more of their interior lives but because we worked with them while going through something immense.
</p>
<div class="c-float-right c-float-hang">
<aside id="j4bNuw">
<q>“That technology actually made us more human is a fascinating thought”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rOjIAd">
“It was in fact a shared experience, but it was also coping with the shared experience together. It was people helping each other do it better,” IDC’s Kurtzman said. “That technology actually made us more human is a fascinating thought.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VKgDrR">
Indeed, one in six people reported crying with a coworker this year, according to Microsoft’s study, and nearly one in three say they are more likely to be their authentic selves at work than last year. About 40 percent said they were less embarrassed when their home life showed up at work compared to how things used to be. All of these interactions correlate with a better sense of well-being, higher productivity, and more positive perceptions of work, according to the study.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="v3Pudn">
Of course, it hasn’t all been smooth sailing. It’s easier to misinterpret text than it is in-person communication, and a lot more of our conversations are happening that way.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JSc8yI">
As such, we’ve become increasingly reliant on emoji to convey what we’re trying to say.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kFC9ja">
On Slack, emoji usage jumped a whopping 80 percent since the onset of the pandemic when we shifted to remote work, according to the company. According to a survey commissioned by Slack, the five most popular remote work emoji are the face with tears of joy, red heart, thumbs up, rolling on the floor laughing, and smiling face with heart eyes.
</p>
<h3 id="xhqFP8">
<ol start="10" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">More of your colleagues will live somewhere else
</li></ol></h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1OuZBd">
As more people can work from anywhere, more people will. There’s been more than a five-fold increase in the number of remote job postings on LinkedIn compared with last year. And nearly half of workers said they’re planning to move now that they can work remotely, according to both the Microsoft survey and one from Owl Labs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wE0qCx">
This has the potential to reverse a decades-long move toward big cities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UL1njP">
“The shift to the big cities has been decelerated,” Emergent Research’s King said, “because at least in the near term — the next three to five years — location won’t matter as much.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wfD47G">
Already <a href="https://www.wsj.com/articles/how-remote-work-is-reshaping-americas-urban-geography-11614960100">rents have plunged in big cities</a> like New York and San Francisco, while climbing in second- and third-tier cities like Greensboro, North Carolina, and Albuquerque, New Mexico. In turn, industries built up alongside major office worker cities <a href="https://www.vox.com/policy-and-politics/22264320/jobs-report-unemployment-rate-inequality">could struggle</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PDquAp">
For those knowledge workers who move, this is a chance for more freedom in where they live and the chance to enjoy a higher standard of living than they had when tethered to big expensive cities. For employers, this means access to a wider range of talent than can be found in the city they’re headquartered in.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0dSPz4">
It’s one of the many changes the pandemic has wrought on office work.
</p>
<div class="c-wide-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/1MIkgYP_ock3mkX7XeMReN_YWkU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22383822/GettyImages_1305380979.jpg"/> <cite>Spencer Platt/Getty Images</cite>
<figcaption>
Office buildings stand largely empty in New York City on March 4, 2021.
</figcaption>
</figure>
</div></li>
<li><strong>What we’re leaving behind after the pandemic, from sweatpants to alcohol</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/KKAMT3aglInPLJbl1uPMJ1CL9eY=/750x0:5250x3375/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69010764/GettyImages_1286811639.0.jpg"/>
<figcaption>
The next phase is coming. | zf L/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Ten Americans on the products and behaviors they won’t bring into the next chapter of their lives.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YvsKrw">
Last fall, as I prepared to downsize for a cross-country move, I found myself performing a pandemic-era <a href="https://www.vox.com/culture/2019/1/11/18175683/marie-kondo-tidying-up-netflix-life-changing-magic-konmari-explained">KonMari ritual</a> of my own.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MGPO9S">
Sitting on the floor of my room surrounded by a mountain of relics from my past, I tried to imagine myself on the other side of the pandemic. Holding a Kate Spade purse, its leather faded and limp from years of wear, I was overtaken by a feeling of alienation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UAjTdt">
In many ways, the girl who’d bought that bag had become a stranger to me. She wore heels to the office and still ascribed to the Gospel of Girl Boss. She’d actually thought the 70-percent-off designer office wear she bought at TJ Maxx would buy her clout in the corporate world. It wasn’t just the purse. Suddenly a closet full of blazers and sheath dresses looked like a hall of artifacts from a bygone era.
</p>
<div class="c-float-right">
<aside id="KSGAhP">
<q>The girl who’d bought that bag had become a stranger to me</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="o1Ti9R">
Working from home was part of it, of course, but there was also a deeper disillusionment with the kinds of things I’d been taught to want and the kind of society that upheld them. Amid economic recession, vast inequality, and nationwide suffering, items meant to convey status (as impostering as mine ever was) felt more tasteless and wasteful than ever.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zC6GIC">
The lack of social influence had also distilled my own tastes and desires to become more my own. I didn’t know which style of jeans were in, so I just wore the ones I liked. On weekends, when I was feeling particularly down, I dressed up in outfits for myself alone, noticing they were much bolder and brighter than anything I used to wear in public.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VHOh8R">
There were other things too. My stack of apocalypse novels, once my preferred genre, seemed redundant if not repulsive against the backdrop of the daily news. I found it hard to believe that I’d once refused to go to the corner store without a coat of mascara. I made a resolution to stop plugging my ears with headphones every time I made an outing, wanting to never take those little daily public interactions for granted again.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jjOFEb">
As a pinprick of light finally starts to glimmer at the end of the Covid-19 tunnel, items will be jettisoned from our lives as a result of this transformative year, both naturally and by choice. Many people I’ve talked to say they will embrace the mellower, more comfortable norms of the socially distant lifestyle. Others, however, anticipate ricocheting in the opposite direction, choosing maximalism in all aspects of life to get as far away from this traumatic year as possible. But everyone, in one way or another, is leaving something — and some part of themselves — behind.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZT3HXf">
These responses have been lightly edited for length and clarity.
</p>
<h3 id="UFIeiO">
Foundation
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mdPfh3">
<strong>Claire, Los Angeles</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BV6Nne">
Before the pandemic, I did not leave the house without foundation. I couldn’t stand the pinkness of my face, and I had really bad adult acne until a few years ago. Men on the street would often ask me about it or make fun of me. I felt embarrassed to be out in the world without makeup.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tYE0LT">
For a long time, I refused to have mirrors in my house. Now I’m on Zoom all the time, and before I discovered hide self-view I was constantly seeing my own face. For the first time it was like, “Yeah, I’m a pink person. So what?” It just seemed so insignificant suddenly. My appearance, the idea of having my face perceived by other people, started to feel so much less fragile. We were all just little faces on the screen.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rZrmD2">
I think there’s still fun to be had with makeup. There’s a big difference between a statement lip or black eyeliner — the kind of makeup that’s about being more expressive — and the kind of makeup that’s meant for hiding your face.
</p>
<h3 id="x8PhZy">
Nonlocal shopping
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KtlS5R">
<strong>Patricia, Brooklyn</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QovImj">
All this excess that people have been chasing … Now the pandemic has forced us into thinking, “Why do we need all of these things?” Now, less is more. I really believe the pandemic is going to change the way we shop. I want people to start buying locally. All the books and clothes that I sell in my store are recyclables. They’re either from thrift shops or donations or finds. Why do I have to go to the source when there’s so much that’s already out there?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4quf1g">
I’ve met a lot of people this year in my shop who probably never would have spoken to me before. People were so self-absorbed that they didn’t really engage. Now people share. We all get to learn about each other, which is something I think we as Americans need to do, because then we’ll see how much we have in common — and how together we can create something better. We need to stop with the “me, me, me” attitude, which has not led to anything good. I really believe that the country is changed, or is about to. I think the days of spend, spend, spend<em> </em>and buy, buy, buy,<em> </em>whether we need it or not, are over. I think it’s time for people to rethink, “Where do we go from here?”
</p>
<h3 id="5Bq6fE">
Apple Watch
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7VXep0">
<strong>Tobias, Oakland</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4Ti7yY">
I took off my Apple Watch at the beginning of the pandemic, and it seems doubtful that I’ll put it back on. I’m multitasking less. Usually if someone’s texting me, it’s not an urgent, “What time are we meeting up?” and it can wait until I’m done with whatever I’m doing. Overall, I’m responding to people a lot slower, which is sometimes good and sometimes feels rude.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="O0KhEp">
It was also very useful while commuting, which I’m not doing anymore. Even as I’ve gotten back into exercising, I’m less inclined to want the whole gamified, “Good job! You burned X calories every day this week!” aspect. It’s an accessory for a version of me that wanted a faster-paced life, and I think I just want that less now.
</p>
<h3 id="ufpqZ5">
Alcohol
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TYvRQc">
<strong>Ottavia, Los Angeles</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BEhgSc">
My birthday was on March 16, the day things started to get really serious in Los Angeles last year. My partner and I bought a bottle of wine to celebrate, and that’s when I realized that drinking only made me feel so much worse about an already bad situation. Then everything slowed down, especially socially. There wasn’t that much reason to drink, so I stopped.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pbD1ZR">
It was a completely personal thing for me. I know that for other people it can be a comfort, or a part of their routine they don’t want to give up, and I don’t see anything wrong with that. I just know that I feel better mentally, emotionally, and physically. Saving money is a big part of it, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OgKH1N">
I’ve been to small get-togethers and even then I haven’t really wanted to drink. I can have just as nice a time without it.
</p>
<h3 id="4lZqvX">
Sweatpants
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fAbieG">
<strong>Annie, Providence, Rhode Island</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h3jto6">
When we were all sent home from college last spring, I wore the same sweatpants and sweatshirt for a week and a half. I just couldn’t bring myself to change my clothes. But then as quarantine kept going, I started to push myself to wear things that would make me feel cute.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i3kHqy">
Now they have me living in a hotel nearby, so whenever I go up to campus it’s kind of an event. I like to wear funky stuff. Anything with a bit more personality, a print, or bright colors. Walking up the hill is my runway now.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aOVtO2">
The chance to dress up is something I took for granted when I was at school before the pandemic. I would wear sweats to class. I’ll have higher standards for myself now that my time in college has been cut in half. What’s the point of going out and not fully enjoying yourself? For me, getting dressed up is part of that.
</p>
<h3 id="Z4KLUf">
Going to bed late
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wM4j80">
<strong>Tori, Houston</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X8qggm">
I have never been a morning person. I used to stay up until midnight or 1 am and was always my most creative and energetic at night. Then this year I got a new remote job that started at 6:30 am. I was still staying up until 11, and then I’d be a nonfunctioning human until 9 am, which just wasn’t working. Then I read that <a href="https://www.thecut.com/2018/10/an-argument-for-going-to-bed-super-early.html">article in the<em> </em>Cut</a><em> </em>that says the best time to go to sleep is 8:45, so I started taking melatonin at 8 and passing out before 9.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nAsf80">
I not only got so much more work done, I [also] felt like my days were fuller. I got to see the sunrise. I started making these elaborate breakfasts. And going to bed made me so happy! Now if I go out to eat with a friend, I can be more confident in saying I’m not gonna have another drink and going home. I have a bedtime now, and I really do not see that stopping.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A3afD3">
It has actually made me more in control of my behavior during the day. I feel calmer, more at peace. Now I‘m most creative in the morning. I have way more energy, and an hour after I wake up, I’m ready to roll. It’s shifted my entire nature. I look back at my pre-pandemic self and she seems like a child! This year, as horrible as it’s been, has been an opportunity to experiment with things we never would have otherwise. It’s shown me who I want to be and what I want for myself — not on a grand scale, necessarily, but every day.
</p>
<h3 id="0hIKYs">
My gym membership
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GLSjt5">
<strong>Charlie, Los Angeles</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D3Ra4V">
I am going to leave behind my gym membership, which seems like the opposite of what a lot of people are going to do, but I just realized that gyms are a cesspool of germs and a waste of money. I bought myself a set of parallel bars instead to use at home. If I want to exercise, I shouldn’t hold myself hostage by paying for a membership. I should just get my ass out of bed and work out.
</p>
<h3 id="J1gQhc">
Instagram
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A33vif">
<strong>Kate, Longmont, Colorado</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nWAyxw">
I used to use Instagram a lot when I was actually doing things — visiting friends, going on work trips, doing things with my spouse. It was like I was telling the world, “Look at what this says about me!” I’ve been asking myself why I never feel inclined to put any part of my life into a semipublic forum anymore.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rEeeqt">
My last Instagram post was a picture of me and my chicken, the last week of March 2020. Now, it’s like, what am I gonna show you, a picture of the 34 hats I knitted in 2020? This weird cocktail I made up? My dogs? I just didn’t care anymore about broadcasting my life. It made me realize that curating this grid for a bunch of people you don’t know that well was always pretty meaningless.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vHsu9J">
The moment it really changed for me was during the Black Lives Matter protests in June. So many people used Instagram as this virtue-signaling tool. On one hand, it’s like, yes, every person should be active in this movement. On the other hand, so many of those people were the same people who went on vacation to Mexico in October. They went to one protest and haven’t worked for any significant change since. Then they’re going on this very same app to showcase activities that actively put lives in danger.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DH3dzu">
I only have so much energy in a day. Now I want to put that energy and effort I used to put into Instagram into actively engaging with the world and the people I care about.
</p>
<h3 id="Bgvcdn">
Airport lounge passes
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jMxCpM">
<strong>Katharina, Atlanta</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2LOko4">
If I can, I’ll always travel as much as humanly possible. The pass has always been worth it in the past, especially with a baby in tow. But I suspect prices will go up — the airlines will have to get their lost revenue somehow — and travel now is just weird. Buffets at lounges are questionable, and how quickly will we be comfortable with a packed lounge? Things will be odd for a good while. Plus, several countries will have tight border restrictions for another year minimum, I’m sure. Travel will not be easy, fast, or cheap in the foreseeable future. So I may well give it up for at least a year or two. I remain hopeful it won’t be longer.
</p>
<h3 id="bbEuqP">
In-person first dates
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V9VOn0">
<strong>Sarah, New York</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xWV179">
There are so many advantages to a remote first date. I can see if they actually look like their pictures, we can see if we have a connection, it requires minimal makeup, I can throw on a cute top with sweatpants, and it takes 45 minutes. You have much more control over the environment and the situation that you don’t feel like you need a drink. There’s no risk involved. When I do decide to leave my house, it’s not for the possibility of something, it’s for something real.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2246tU">
I’ll definitely keep doing things this way post-pandemic. As you get older, carving out time to date takes more of a commitment. It’s about prioritizing my own time, deciding what’s worth the effort and what isn’t.
</p>
<aside id="3nYVh2">
<div>
</div>
</aside></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ISSF World Cup | Ganemat, Angad combine to win mixed skeet gold</strong> - With this, table-topper India’s gold medal haul at the ongoing event went up to seven</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NZ vs Bangladesh | Latham century helps New Zealand take 2-0 series lead</strong> - In a match of odd equivalences, captains Latham and Iqbal were the respective top-scorers for their teams. Iqbal made 78 in Bangladesh’s 271-6 and Latham made an unbeaten 110 as New Zealand reached 275-5 with 10 balls to spare</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ind vs Eng | England win toss, opt to field in first ODI</strong> - India beat England 3-1 in the four-Test series before claiming a 3-2 victory in the five-match T20 series on Saturday.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India vs England | Time for ODIs as evenly-matched teams vie to outperform each other</strong> - India will be keen to accommodate both Suryakumar and Pant; Rohit and Dhawan to open; Wood has to fire for England in the absence of Archer</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Players need to be consulted on schedule, says Virat Kohli</strong> - Kohli underlines the impact of biosecure hub during the pandemic</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Don’t impose books of private publishers, Punjab’s private schools told</strong> - Accreditation, no-objection certificate of the guilty schools will be revoked, says Punjab govt.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Health Mission led to improved indices: Ministry</strong> - 18,779 personnel engaged in 2019-20, MMR, IMR declined, says Health Ministry</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>VACB recommends case against Shaji</strong> - A special unit of the Vigilance and Anti Corruption Bureau (VACB) has proposed that a case can be taken up against IUML legislator K.M. Shaji for alle</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>BJP seeks cancellation of sand contract</strong> - ‘State govt. hiked the price from ₹370 to ₹470 a tonne’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Repeal farm laws and proposal to privatise steel plant, says CPI(ML)</strong> - ‘Lakhs of families are dependent on the VSP’</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Germany imposes Easter lockdown to curb new surge</strong> - Rising infections have put Germany in a “very serious” situation, Chancellor Angela Merkel says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia and China hit back at Western sanctions</strong> - Russia firmly backs China, which is stung by Western sanctions for cracking down on Uighurs.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Third wave will ‘wash up on our shores’, warns Johnson</strong> - Boris Johnson says the UK will “feel effects” of growing case numbers in Europe amid a row over vaccines.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Polish writer Jakub Zulczyk charged for calling President Duda a ‘moron’</strong> - Jakub Zulczyk could face up to three years in jail for his Facebook post criticising the president.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Iceland volcano eruption: Onlookers flock to see Mount Fagradalsfjall</strong> - People have trekked to Mount Fagradalsfjall after lava started bursting out on Friday evening.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The secret to a successful wine pairing? Fats have an affinity for tannins</strong> - Tannins interact at molecular level with fat globules in cheeses, meats, and oils. - <a href="https://arstechnica.com/?p=1748648">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Report: The next Nintendo Switch will deliver 4K on TVs via Nvidia’s DLSS</strong> - Also claims a jump in general specs—but how exactly will DLSS’ wizardry be toggled? - <a href="https://arstechnica.com/?p=1751441">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Judge grants class-action status to MacBook butterfly-keyboard suit</strong> - Apple phased out the design after 2019, but older models still have issues. - <a href="https://arstechnica.com/?p=1751264">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>YouTuber Patrick (H) Willems has thoughts on movies—lots of thoughts</strong> - In this edition of “Personal History,” we talk with Willems about his YouTube comments. - <a href="https://arstechnica.com/?p=1751239">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Richard Stallman returns to FSF 18 months after controversial rape comments</strong> - Stallman quit in 2019 after emails about Jeffrey Epstein and age-of-consent laws. - <a href="https://arstechnica.com/?p=1751252">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Netflix is soon releasing an extremely realistic documentary series about the life of Abraham Lincoln.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The finale is shot before a live audience.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/porichoygupto"> /u/porichoygupto </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mb03u9/netflix_is_soon_releasing_an_extremely_realistic/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mb03u9/netflix_is_soon_releasing_an_extremely_realistic/">[comments]</a></span></p></li>
<li><strong>My Friend Asked Me to Stop Singing “I’m a Believer”. I Thought She Was Joking…</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
But then I saw her face
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/TheButterSlice"> /u/TheButterSlice </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mb2v6a/my_friend_asked_me_to_stop_singing_im_a_believer/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mb2v6a/my_friend_asked_me_to_stop_singing_im_a_believer/">[comments]</a></span></p></li>
<li><strong>Dude explaining how he made his first $10 million:</strong> - <!-- SC_OFF -->
<div class="md">
<ol>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Get up at 5:00AM every day<br/>
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
90 minutes of cardio<br/>
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Take a cold shower<br/>
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Journal<br/>
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Schedule out your day<br/>
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Dad owns Fortune 500 company<br/>
</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Meditate
</li>
</ol>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/lopezjessy"> /u/lopezjessy </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mbccca/dude_explaining_how_he_made_his_first_10_million/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mbccca/dude_explaining_how_he_made_his_first_10_million/">[comments]</a></span></p></li>
<li><strong>There has been two mass shootings within a week of each here in the United States.</strong> - <!-- SC_OFF -->
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It’s only been one year since COVID lockdowns but it looks like America is finally getting back to normal
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Yeetaway987"> /u/Yeetaway987 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/mba5i7/there_has_been_two_mass_shootings_within_a_week/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/mba5i7/there_has_been_two_mass_shootings_within_a_week/">[comments]</a></span></p></li>
<li><strong>I told my daughter, “Did you know that humans eat more bananas than monkeys?” She rolled her eyes at me, but I persevered. “It’s true!”</strong> - <!-- SC_OFF -->
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“When was the last time you ate a monkey?!”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/honolulu_oahu_mod"> /u/honolulu_oahu_mod </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/makjvw/i_told_my_daughter_did_you_know_that_humans_eat/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/makjvw/i_told_my_daughter_did_you_know_that_humans_eat/">[comments]</a></span></p></li>
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