diff --git a/archive-covid-19/03 January, 2021.html b/archive-covid-19/03 January, 2021.html new file mode 100644 index 0000000..75e03fd --- /dev/null +++ b/archive-covid-19/03 January, 2021.html @@ -0,0 +1,179 @@ + +
+ + + ++The ongoing COVID-19 pandemic has shifted attention to the airborne transmission of exhaled droplet nuclei within indoor environments. The spread of aerosols through singing and musical instruments in music performances has necessitated precautionary methods such as masks and portable purifiers. This study investigates the effects of placing portable air purifiers at different locations inside a classroom, as well as the effects of different aerosol injection rates (e.g., with and without masks, different musical instruments and different injection modes). Aerosol deposition, airborne concentration and removal are analyzed in this study. It was found that using purifiers could help in achieving ventilation rates close to the prescribed values by the World Health Organization (WHO), while also achieving aerosol removal times within the Center of Disease Control and Prevention (CDC) recommended guidelines. This could help in deciding break periods between classroom sessions, which was around 25 minutes through this study. Moreover, proper placement of purifiers could offer significant advantages in reducing airborne aerosol numbers (offering orders of magnitude higher aerosol removal when compared to nearly zero removal when having no purifiers), and improper placement of the purifiers could worsen the situation. The study suggests the purifier to be placed close to the injector to yield a benefit, and away from the people to be protected. The injection rate was found to have an almost linear correlation with the average airborne aerosol suspension rate and deposition rate, which could be used to predict the trends for scenarios with other injection rates. +
+Dendritic Cell Vaccine to Prevent COVID-19 - Condition: COVID-19
Intervention: Biological: AV-COVID-19
Sponsors: Indonesia-MoH; Aivita Biomedical, Inc.; PT AIVITA Biomedika Indonesia; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia; RSUP Dr. Kariadi Semarang, indonesia; Faculty of Medicine University of Diponegoro, Indonesia
Recruiting
Effect of Dalcetrapib in Patients With Confirmed Mild to Moderate COVID-19 - Condition: Covid19
Interventions: Drug: Dalcetrapib; Other: Placebo
Sponsors: DalCor Pharmaceuticals; The Montreal Health Innovations Coordinating Center (MHICC); Covance
Not yet recruiting
suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19 - Condition: Covid19
Interventions: Drug: Anakinra; Drug: Placebo
Sponsor: Hellenic Institute for the Study of Sepsis
Recruiting
Evaluating the Impact of EnteraGam In People With COVID-19 - Condition: Covid19
Interventions: Dietary Supplement: Bovine Plasma-Derived Immunoglobulin Concentrate; Other: Standard of care
Sponsors: Entera Health, Inc; Lemus Buhils, SL; Clinical Research Unit, IMIM (Hospital del Mar Medical Research Institute)
Not yet recruiting
Efficacy and Safety of Remdesivir and Tociluzumab for the Management of Severe COVID-19: A Randomized Controlled Trial - Conditions: Covid19; Covid-19 ARDS
Interventions: Drug: Remdesivir; Drug: Tocilizumab
Sponsors: M Abdur Rahim Medical College and Hospital; First affiliated Hospital of Xi'an Jiaoting University
Recruiting
Inhaled Ivermectin and COVID-19 - Condition: COVID-19
Intervention: Drug: Ivermectin Powder
Sponsor: Mansoura University
Not yet recruiting
Effect of Tenofovir/Emtricitabine in Patients Recently Infected With SARS-COV2 (Covid-19) Discharged Home - Condition: Covid19
Intervention: Drug: tenofovir disoproxil and emtricitabine
Sponsor: University Hospital, Caen
Recruiting
Safety and Immunogenicity of Two Different Strengths of the Inactivated COVID 19 Vaccine ERUCOV-VAC - Condition: COVID-19 Vaccine
Interventions: Biological: ERUCOV-VAC; Other: Placebo Vaccine
Sponsors: Health Institutes of Turkey; TC Erciyes University
Recruiting
AZD1222 Vaccine in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19 - Condition: COVID-19
Interventions: Biological: AZD1222; Biological: rAd26-S
Sponsors: AstraZeneca; R-Pharm
Not yet recruiting
Anti-COVID19 AKS-452 - ACT Study - Condition: Covid19
Intervention: Biological: AKS-452
Sponsors: University Medical Center Groningen; Akston Biosciences Corporation
Not yet recruiting
Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19. - Condition: COVID-19
Interventions: Biological: AZD1222; Biological: rAd26-S
Sponsors: R-Pharm; AstraZeneca
Not yet recruiting
Surgical Face Mask Effects in Patients With COVID-19 - Condition: Covid19
Intervention: Other: Sit-To-Stand test
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Not yet recruiting
Dendritic Cell Vaccine, AV-COVID-19, to Prevent COVID-19 Infection - Condition: COVID-19
Interventions: Biological: AV-COVID-19; Other: GM-CSF
Sponsors: Aivita Biomedical, Inc.; PT AIVITA Biomedika Indonesia; Indonesia Ministry of Health; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
Recruiting
Efficacy and Safety of hzVSF-v13 in Patients With COVID-19 Pneumonia - Condition: COVID-19
Interventions: Drug: hzVSF-v13; Drug: Placebo (Normal saline solution)
Sponsor: ImmuneMed, Inc.
Recruiting
A Clinical Study to Assess the Efficacy and Safety of Amizon® Max in the Treatment of Moderate Covid-19 - Condition: Covid-19 Disease
Interventions: Drug: Enisamium Iodide; Drug: Placebo
Sponsor: Joint Stock Company "Farmak"
Recruiting
Evaluation of a commercially-available surrogate virus neutralization test for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) - There remains an urgent need for assays to quantify humoral protective immunity to SARS-CoV-2 to understand the immune responses of COVID-19 patients, evaluate efficacy of vaccine candidates in clinical trials, and conduct large-scale epidemiological studies. The plaque-reduction neutralization test (PRNT) is the reference-standard for quantifying antibodies capable of neutralizing SARS-CoV-2. However, the PRNT is logistically demanding, time-consuming, and requires containment level-3...
In silico study of the potential interactions of 4'-acetamidechalcones with protein targets in SARS-CoV-2 - The sanitary emergency generated by the pandemic COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 20 million people were reported with the infection. Of these, more than 740,000 died. In view of the situation, strategies involving the development of new antiviral molecules are extremely important. The present work...
Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2 - The SARS-CoV-2 outbreak, began in late 2019, has caused a worldwide pandemic and shows no signs of slowing. Glucocorticoids (GCs), including dexamethasone (DEX), have been widely used as effective anti-inflammatory and immunosuppressant drugs. In this study, seven GCs had no obvious effect on cell viability of angiotensin converting enzyme 2 (ACE2) high expressed HEK293T cells when concentrations were under 10 μM. Molecular docking results revealed that DEX occupied with active binding site of...
Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine - CONCLUSIONS: These preclinical findings support clinical investigation of the repurposing of CPZ, a largely used drug with mild side effects, in COVID-19 treatment.
Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulations - The COVID-19 pandemic has spread rapidly and posed an unprecedented threat to the global economy and human health. Broad-spectrum antivirals are currently being administered to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). China's prevention and treatment guidelines suggest the use of an antiinfluenza drug, arbidol, for the clinical treatment of COVID-19. Reports indicate that arbidol could neutralize SARS-CoV-2. Monotherapy with arbidol is found to be superior to...
Antitumor/antiviral carbon quantum dots based on carrageenan and pullulan - Requirement for medication from pathogenic human viruses and cancer diseases are urgently considered, while, numerous reports were focused on investigating easily manufactured and excellently effective therapeutic reagents. Herein, CQDs were prepared with size of 2.1 nm from both of carrageenan and pullulan. CQDs nucleated from pullulan showed higher anti-proliferative effects against cancer cells, while, treatment with 100 μg/mL of CQDs colloids originated from pullulan and carrageenan...
Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46 - Human adenovirus species D (HAdV-D) types are currently being explored as vaccine vectors for coronavirus disease 2019 (COVID-19) and other severe infectious diseases. The efficacy of such vector-based vaccines depends on functional interactions with receptors on host cells. Adenoviruses of different species are assumed to enter host cells mainly by interactions between the knob domain of the protruding fiber capsid protein and cellular receptors. Using a cell-based receptor-screening assay, we...
A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro - The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus poses serious threats to the global public health and leads to worldwide crisis. No effective drug or vaccine is readily available. The viral RNA-dependent RNA polymerase (RdRp) is a promising therapeutic target. A hybrid drug screening procedure was proposed and applied to identify potential drug candidates targeting RdRp from 1906 approved drugs. Among the four selected market available drug candidates,...
MicroRNAs and SARS-CoV-2 life cycle, pathogenesis, and mutations: biomarkers or therapeutic agents? - To date, proposed therapies and antiviral drugs have been failed to cure coronavirus disease 2019 (COVID-19) patients. However, at least two drug companies have applied for emergency use authorization with the United States Food and Drug Administration for their coronavirus vaccine candidates and several other vaccines are in various stages of development to determine safety and efficacy. Recently, some studies have shown the role of different human and severe acute respiratory syndrome...
Fisetin 8-C-glucoside as entry inhibitor in SARS CoV-2 infection: molecular modelling study - Coronaviruses are RNA viruses that infect varied species including humans. TMPRSS2 is gateway for SARS CoV-2 entry into the host cell. It causes proteolytic activation of spike protein and discharge of the peptide into host cell. The TMPRSS2 inhibition could be one of the approaches to stop the viral entry, therefore, interaction pattern and binding energies for Fisetin and TMPRSS2 have been explored in the present study. TMPRSS2 peptide was used for homology modelling and then for further...
A narrative review of hydrogen-oxygen mixture for medical purpose and the inhaler thereof - Recent development regarding mixture of H(2) (concentration of ~66%) with O(2) (concentration of ~34%) for medical purpose, such as treatment of coronavirus disease-19 (COVID-19) patients, is introduced. Furthermore, the design principles of a hydrogen inhaler which generates mixture of hydrogen (~66%) with oxygen (~34%) for medical purpose are proposed. With the installation of the liquid blocking module and flame arresters, the air pathway of the hydrogen inhaler is divided by multiple...
Developing multiplex ddPCR assays for SARS-CoV-2 detection based on probe mix and amplitude based multiplexing - Introduction: With the ongoing SARS-CoV-2 pandemic, different articles have been published highlighting the superiority of droplet digital PCR (ddPCR) over the gold-standard reverse transcription PCR (RT-PCR) in SARS-CoV-2 detection. However, few studies have been reported on developing multiplex ddPCR assays for SARS-CoV-2 detection and their performance. This study shows steps on how to develop different ddPCR SAR-CoV-2 assays including higher order multiplex assays for SARS-CoV-2 detection...
Tocilizumab combined with favipiravir in the treatment of COVID-19: A multicenter trial in a small sample size - CONCLUSION: Tocilizumab combined with or without favipiravir can effectively improve the pulmonary inflammation of COVID-19 patients and inhibit the deterioration of the disease.
Therapeutic approaches against coronaviruses acute respiratory syndrome - Coronaviruses represent global health threat. In this century, they have already caused two epidemics and one serious pandemic. Although, at present, there are no approved drugs and therapies for the treatment and prevention of human coronaviruses, several agents, FDA-approved, and preclinical, have shown in vitro and/or in vivo antiviral activity. An in-depth analysis of the current situation leads to the identification of several potential drugs that could have an impact on the fight against...
The British variant of the new coronavirus-19 (Sars-Cov-2) should not create a vaccine problem - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious virus that infects humans and a number of animal species causing coronavirus disease-19 (COVID-19), a respiratory distress syndrome which has provoked a global pandemic and a serious health crisis in most countries across our planet. COVID-19 inflammation is mediated by IL-1, a disease that can cause symptoms such as fever, cough, lung inflammation, thrombosis, stroke, renal failure and headache, to name a few....
Covid 19 - Chewing Gum - - link
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link
제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - link
Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link
SARS-CoV-2 RBD共轭纳米颗粒疫苗 - 本发明涉及免疫医学领域,具体而言,涉及一种SARS‑CoV‑2 RBD共轭纳米颗粒疫苗。该疫苗包含免疫原性复合物,所述免疫原性复合物包含:a)与SpyCatcher融合表达的载体蛋白自组装得到的纳米颗粒载体;b)与SpyTag融合表达的SARS‑CoV‑2病毒的RBD抗原;所述载体蛋白选自Ferritin、mi3和I53‑50;所述载体蛋白与所述抗原之间通过SpyCatcher‑SpyTag共价连接。 - link
Устройство электронного контроля и дистанционного управления аппарата искусственной вентиляции легких - Полезная модель относится к медицинской технике, а именно к устройствам для воздействия на дыхательную систему пациента смесью различных газов, в частности, к устройствам для проведения искусственной вентиляции легких (ИВЛ). Технический результат предлагаемой полезной модели заключается в решении технической проблемы, состоящей в необходимости расширения арсенала технических средств, предназначенных для электронного контроля и управления ИВЛ, путем реализации возможности дистанционного управления аппаратами ИВЛ в медицинских учреждениях, не оборудованных кабельными вычислительными сетями. Указанный технический результат достигается благодаря тому, что в известное устройство электронного контроля и дистанционного управления аппарата ИВЛ, содержащее центральный микроконтроллер, а также программно-аппаратные средства управления функциями доставки воздушной смеси пациенту и многоуровневой тревожной сигнализации об отклонениях от нормативных условий и технических неполадках в аппарате ИВЛ, введены связанные друг с другом микроконтроллер связи и дистанционного управления и радиомодем, выполненный с возможностью связи с точками доступа радиканальной сети, при этом центральный микроконтроллер устройства выполнен с дополнительными входом/выходом, которые связаны с управляющими выходом/входом микроконтроллера связи и дистанционного управления, а, в зависимости от типа применяемой в медицинском учреждении радиоканальной сети связи и передачи данных, радиомодем может быть выполнен в виде интерфейсного аудиомодуля Bluetooth 4.0 BLE, приемопередающего модуля Wi-Fi либо устройства "малого радиуса действия", работающего по технологии LoRa на нелицензируемых частотах мегагерцового диапазона, например, в диапазоне 868 МГц. 3 з.п. ф-лы, 1 ил. - link
Can Boosting Child and Elder Care Help Democrats Win Control of the Senate? - Groups canvassing in Georgia say that the “care economy” is a pivotal issue to voters. - link
Can Democrats Win Georgia—and the Senate? - In order to do so, the candidates will need high voter turnout in a state where it tends to drop during runoffs, especially among the Party’s own supporters. - link
The Real Republican Radicals - The Trump movement was long understood as a populist one. But, since the election, the people at the barricades have been politicians and their lawyers. - link
Deconstructing the 2020 Latino Vote - The political preferences of white working-class voters and soccer moms have been dissected in detail—and now strategists are applying the same level of focus to Latino voters. - link
The Trümperdämmerung Is a Fitting End to 2020 - The President is careening through his final days in office with reckless disdain—for everything. - link
+At least 12 Republican senators will object to certifying the results of the 2020 election. +
++On Saturday, 11 current and incoming Republican senators announced in a joint statement that they would object to the congressional certification of President-elect Joe Biden’s Electoral College victory next week in a futile effort to hand outgoing President Donald Trump an unelected second term in office. +
++The statement — led by Texas Sen. Ted Cruz — also calls for the creation of an electoral commission modeled on a similar committee assembled in 1877, saying the commission would conduct “an emergency 10-day audit of the election returns in the disputed states.” +
++Citing “unprecedented allegations of voter fraud, violations and lax enforcement of election law, and other voting irregularities,” the letter also argues that states should be allowed to “evaluate the Commission’s findings and could convene a special legislative session to certify a change in their vote, if needed.” +
++++NEW: @SenTedCruz leads a group of senators calling for an emergency ten-day audit of Electoral College results. pic.twitter.com/owjvsgwXt2 +
+— Grace Segers (@Grace_Segers) January 2, 2021 +
+The days after the 2020 election have indeed seen unprecedented allegations of voter fraud — but all have been found to be without merit by the judicial system, state elected officials, national security officials, and elections officials. Nevertheless, Cruz and the other members of the group — Sens. Ron Johnson, James Lankford, Steve Daines, John Kennedy, Marsha Blackburn, and Mike Braun, as well as Senators-elect Cynthia Lummis, Roger Marshall, Bill Hagerty, and Tommy Tuberville — maintain otherwise. +
++Lummis, Marshall, Hagerty, and Tuberville were elected in November and have yet to be sworn in, but will be seated Sunday ahead of a session of Congress dedicated to the electoral vote certification on January 6. +
++In their plans to object to the certification, the 11 lawmakers join Missouri Sen. Josh Hawley, who announced his own plan to object last week, and a sizable majority of the House Republican Conference, led by Trump devotees like Rep. Louie Gohmert, who have said they will do the same. +
++“74 million Americans are not going to be told their voices don’t matter,” Hawley said of his effort on December 30, conveniently ignoring the fact Biden won the election by a margin of more than 7 million votes over Trump, and that, in the US system, their votes hold equal weight. +
++++Somebody has to stand up. 74 million Americans are not going to be told their voices don’t matter pic.twitter.com/DMa7sRyoAh +
+— Josh Hawley (@HawleyMO) December 31, 2020 +
+Ultimately, the Republican plan to object will lead nowhere. Though a bicameral group of Republicans will be able to successfully object to the certification of results, the Democratic majority in the House means that the effort will ultimately fail there — and it may not stand much of a chance in the Senate either, where the No. 1 and No. 2 Republicans in the chamber — Majority Leader Mitch McConnell and Majority Whip John Thune — have come out against it. +
++“In the Senate, it would go down like a shot dog,” Thune told reporters in December 2020. “I just don’t think it makes a lot of sense to put everybody through this when you know what the ultimate outcome is going to be.” +
++Other Republicans, including Sens. Mitt Romney and Ben Sasse, have criticized Hawley’s plan. And In a statement Saturday, Sen. Lisa Murkowski (R-AK) came out strongly against the lawmakers’ plan to object. +
++“I swore an oath to support and defend the Constitution of the United States,” she said, “and that is what I will do January 6 — just as I strive to do every day as I serve the people of Alaska. I will vote to affirm the 2020 presidential election.” +
++++Sen. @LisaMurkowski (R-Alaska): "I swore an oath to support and defend the Constitution of the United States and that is what I will do January 6—just as I strive to do every day as I serve the people of Alaska. I will vote to affirm the 2020 presidential election." pic.twitter.com/P2JYIXXahD +
+— Sahil Kapur (@sahilkapur) January 2, 2021 +
+Pennsylvania Sen. Pat Toomey, who represents one of the swing states Trump has contested, also criticized those who plan to oppose the certification on Saturday, saying in a statement: “A fundamental, defining feature of a democratic republic is the right of the people to elect their own leaders. The effort by Senators Hawley, Cruz, and others to overturn the results of the 2020 presidential election in swing states like Pennsylvania directly undermines this right.” +
++Trump, on the other hand, signaled support for the lawmakers’ efforts, retweeting Hawley’s praise of Cruz and his allies, and seeming to characterize certification as “an attempt to steal a landslide win.” +
++Plan to object aside, the “electoral commission” plan backed by Cruz and 10 of his colleagues is nonsense. For one, the commission they demand has no precedent in the modern era and no realistic prospects of being convened. What’s more, the statement is predicated on a series of spurious claims by Cruz and his colleagues that echo similar — and equally baseless — election fraud rhetoric to that heard repeatedly from Trump. +
++Election Day — November 3, 2020 — is now 60 days in the past. In that time, Trump and his Republican allies have filed and lost at least 60 election-related lawsuits at all levels of the state and federal court systems alleging voter fraud and other improprieties — and they have failed to prove their case at every turn. +
++Recounts in battleground states like Georgia and Wisconsin — both won by Biden — have turned up no evidence of large-scale fraud or irregularities that could have affected the results of the election. And in all 50 states and Washington, DC, the election results have been carefully reviewed by state officials and certified as accurate. +
++In short, 60 days of intense scrutiny has turned up exactly zero reasons to believe the letter’s false claim that “the allegations of fraud and irregularities in the 2020 election” are worrying — and there’s no reason to believe that an “electoral commission” would turn up a different result. +
++That there have been allegations of fraud as never before is true, but as MSNBC’s Chris Hayes pointed out on Sunday, these have been misleading efforts led by Trump, and bolstered by his allies, like Cruz, to overturn the election’s rightful results. +
++Cruz and his allies cite the results of this effort in their statement Saturday that widespread belief in the existence of voter fraud — a sort of warped “where there’s smoke, there’s fire” argument — necessitates the creation of an election commission. +
++“Reuters/Ipsos polling, tragically, shows that 39% of Americans believe ‘the election was rigged’,” the group said Saturday. “That belief is held by Republicans (67%), Democrats (17%), and Independents (31%).” +
++That’s an accurate reporting of the poll’s results — but it does conveniently leave out the likely reason for that widespread belief. +
++In reality, the Republican base has been inundated with evidence-free voter fraud rhetoric from every corner of the right-wing universe — from Trump’s Twitter feed to Fox News to stump speeches by Republican senators — almost nonstop since Trump’s election defeat. There’s a direct line between Cruz’s rhetoric and the problem he diagnoses: As Hayes put it on Twitter, “They’ve spent months lying to people, telling them the election was stolen and now turn around and cite the fact that many people believe them as evidence!” +
++Ultimately, Saturday’s statement is just the latest foray in a flailing Republican effort to keep Trump in office in opposition to the will of the people. Given that any challenge to certification can be dissolved by a majority vote, and that there are more than enough opponents to these challenges in both the House and Senate, Cruz’s plan seems unlikely to work. +
++Biden is poised to again be affirmed the next president on January 6 ahead of his January 20 inauguration. But if Cruz and his colleagues are as genuinely concerned about a “deep distrust of our democratic processes” that “poses an ongoing threat to the legitimacy of any subsequent administrations” as they claim, their own role in disrupting trust in the electoral process deserves review. +
++Iran plans to enrich uranium to 20 percent purity — a level it last reached before the 2015 nuclear deal. +
++An international nuclear watchdog agency said Friday that Iran is preparing to ramp up uranium enrichment to pre-nuclear deal levels in what would be the country’s latest violation of the 2015 agreement. +
++According to the International Atomic Energy Agency, Iran plans to substantially increase enrichment levels at its underground Fordow nuclear site, which was prohibited from enriching uranium under the terms of the 2015 Joint Comprehensive Plan of Action (JCPOA), an international agreement often known as the Iran nuclear deal, which saw Iran limit its nuclear program in exchange for the relaxation of sanctions. +
++Iran resumed enrichment activities at Fordow in November 2019, following President Donald Trump’s 2018 decision to tear up the nuclear deal — but at a relatively low level, only about 4.5 percent. +
++If Iran follows through on Friday’s pronouncement, that will change. The IAEA says that Iran is now targeting enrichment levels of up to 20 percent, though there is no known timeline in place for that change. +
++Previously, the Iran nuclear deal limited Iran to 3.67 percent enrichment, according to Reuters. To achieve weapons-grade uranium, Iran would have to increase enrichment to 90 percent; but, according to the New York Times’s Eric Schmitt, if Iran were to begin enriching uranium to 20 percent purity, “it requires relatively little further enrichment to get to the 90 percent purity that is traditionally used for bomb-grade fuel.” +
++Iran has repeatedly said it does not want to develop nuclear weapons, and instead wants to advance its nuclear program for peaceful, scientific purposes. Adversaries such as the United States and Israel, however, have signaled they believe otherwise. +
++The new 20 percent enrichment target was set by Iran’s parliament last month in response to the assassination of the country’s top nuclear scientist, Mohsen Fakhrizadeh. Fakhrizadeh was killed near Tehran on November 27, 2020, in an ambush that Iran has blamed on Israel. +
++And the same new law that mandates 20 percent enrichment also raises the imminent specter of international nuclear inspectors being expelled from the country: According to the New York Times, Iran has set “a two-month deadline for oil and banking sanctions against Iran to be lifted before inspectors are barred.” Currently, the IAEA says it has “inspectors present in Iran on a 24/7 basis and they have regular access to Fordow.” +
++Even before Friday, Iran has been taking steps toward regaining pre-nuclear deal capacity — and potentially toward achieving a nuclear weapon. +
++In November 2020, Iran began operating advanced centrifuges at another underground nuclear facility, Natanz, and its nuclear stockpile stood at more than 12 times the limit imposed by the JCPOA. +
++US President-elect Joe Biden, who will take office on January 20, has indicated that he hopes to rejoin and revive the JCPOA, which was negotiated while he was serving as vice president to President Barack Obama. Some observers see Iran’s enrichment efforts as a way of building negotiating leverage, but it remains to be seen whether recent strides in Iran’s nuclear program could complicate things. +
++“I will offer Tehran a credible path back to diplomacy,” Biden wrote in a September op-ed. “If Iran returns to strict compliance with the nuclear deal, the United States would rejoin the agreement as a starting point for follow-on negotiations. With our allies, we will work to strengthen and extend the nuclear deal’s provisions, while also addressing other issues of concern.” +
++Biden isn’t in office yet, though, and in the meantime, tensions between the US and Iran remain high. January 3 will mark the one-year anniversary of the US assassinating Iranian Maj. Gen. Qassem Soleimani with a airstrike in Iraq, an attack that Iran has pledged further retaliation for. +
++Shortly after Soleimani’s killing in January 2020, Iran struck at US forces in Iraq, hitting two air bases with more than a dozen ballistic missiles. +
++There were no casualties from the attack, but more than 100 US service members suffered brain injuries, according to the Pentagon. +
++Until his death last year, Soleimani was the head of the Quds Force, a component of Iran’s Islamic Revolutionary Guard Corps. On Friday, Soleimani’s successor, Esmail Ghaani, warned that “American mischief will not deter the Quds Force from carrying on its resistance path.” +
++“From inside your own house, there may emerge someone who will retaliate for your crime,” Ghaani said. +
++After Fakhrizadeh’s death in November, Iranian President Hassan Rouhani issued a similar threat of retaliation, saying that “Iran will surely respond to the martyrdom of our scientist at the proper time.” +
++In addition to Ghaani’s ominous remarks, CNN reported Friday that Iranian naval forces had moved to a heightened level of readiness, though the reason for the change could be defensive: The US has deployed a submarine and nuclear-capable B-52 bombers to the region in addition to existing forces. +
++Somewhat discordantly, the Pentagon also recalled the aircraft carrier USS Nimitz, which was previously stationed in the Middle East and North Africa region, to its home port in Washington state on Friday. Critics of the decision told the New York Times the recall needlessly limited the US’ retaliatory options at a tense time, but proponents argued that bringing the ship home was a smart deescalatory gesture. +
++As of Saturday, however, that move appears to have done little to deescalate tensions in the region. +
++In a tweet, Iranian Foreign Minister Javad Zarif claimed provocateurs were hoping to spur military action, writing, “New intelligence from Iraq indicate that Israeli agent-provocateurs are plotting attacks against Americans—putting an outgoing Trump in a bind with a fake casus belli. Be careful of a trap, @realDonaldTrump. Any fireworks will backfire badly, particularly against your same BFFs.” +
++++New intelligence from Iraq indicate that Israeli agent-provocateurs are plotting attacks against Americans—putting an outgoing Trump in a bind with a fake casus belli.
+— Javad Zarif (@JZarif) January 2, 2021 +
Be careful of a trap, @realDonaldTrump. Any fireworks will backfire badly, particularly against your same BFFs. +
+Baghdad’s Green Zone, which is home to the US embassy, was the target of a rocket attack last month believed to have been carried out by Iran-linked militias, though Ghaani denied any involvement. +
++In response, Trump has issued threats of his own in recent weeks: “Some friendly health advice to Iran: If one American is killed, I will hold Iran responsible,” Trump tweeted on December 23 after the attack. “Think it over.” +
++++...Some friendly health advice to Iran: If one American is killed, I will hold Iran responsible. Think it over. +
+— Donald J. Trump (@realDonaldTrump) December 23, 2020 +
+Separately, Trump reportedly considered a strike against Iran in November of 2020 but was talked down by his advisers, who warned that such a move could quickly escalate into a larger conflict. +
++Despite the mutual saber-rattling, however, Al Jazeera reported Saturday that some experts believe Iran will look to avoid a major confrontation with the US in anticipation of a coming Biden administration. +
++Northwestern University international studies professor Danny Postel told Al Jazeera, “I think this is a very critical moment in US-Iran relations where there might be a chance to remove war from the equation and find a diplomatic solution to at least this core issue of Iran’s nuclear program.” +
++Vice President Mike Pence will not be allowed to pick the next president. +
++On Friday, a federal court in Texas dismissed the latest in a long line of Republican lawsuits intended to overturn the results of the 2020 presidential election. +
++The suit, which was brought late last year by US Rep. Louie Gohmert (R-TX) and a slate of would-be Republican electors in Arizona, asked the US District Court for eastern Texas to grant Vice President Mike Pence the “exclusive authority and sole discretion under the Twelfth Amendment to determine which slates of electors for a State, or neither, may be counted.” +
++Such authority — which Pence very much lacks — would grant the vice president the power to choose the next president, clearing the way for Pence to throw the election to President Donald Trump and install him to an unelected second term in office. +
++In reality, Pence does have a role to play when Congress meets to certify the Electoral College’s votes on January 6, but it is more a formality than anything. As vice president, Pence is also president of the Senate — thus, according to the 12th Amendment, Pence’s job is to “open all the certificates and the votes shall then be counted.” The actual certification of the votes, though, falls on Congress. +
++In his case, Gohmert claimed vice presidents were meant to be more than “the glorified envelope-opener in chief,” a position at odds with more than a century of established practice. +
++The court, however, didn’t consider the merits of that claim in its Friday ruling. In a 13-page order dismissing the suit, Trump-appointed Judge Jeremy Kernodle concluded that the court was “without subject matter jurisdiction” to hear the suit in the first place, arguing that the plaintiffs lacked standing — essentially, that they would not be harmed should the certification process proceed — that the suit relied too heavily on convoluted hypotheticals, and that the plaintiffs weren’t even suing the right person. +
++Specifically, Gohmert sued Mike Pence — the very person to whom his lawsuit would grant sweeping powers if successful. +
++Pence, understandably, wasn’t exactly on board. In a response from Trump’s own Justice Department requesting that the Texas court deny emergency relief to Gohmert on behalf of Pence — acting Assistant Attorney General Jeffrey Bossert Clark, joined by two deputy assistant attorneys general — wrote that “the Vice President is not the proper defendant to this lawsuit.” +
++“If plaintiffs’ suit were to succeed,” the Justice Department filing continues, “the result would be to remove any constraint the Electoral Count Act places on the Vice President. To the extent any of these particular plaintiffs have a judicially cognizable claim, it would be against the Senate and the House of Representatives.” +
++The New York Times’ Maggie Haberman reported Friday that Trump was upset the Justice Department took this stance, and that he complained to Pence about it. The judge, however, agreed that suing Pence was improper. +
++There were also a few rather important factual errors. Notably, as pointed out by lawyer Akiva Cohen on Twitter, the suit claims that Arizona has appointed competing sets of electors, a situation that would mean the state would submit two sets of votes to Congress. But there are no competing slates of electors, in Arizona or elsewhere. The results of the 2020 presidential election — which was won by President-elect Joe Biden — have been certified in all 50 states and the District of Columbia, and no state legislature attempted to appoint an alternate slate of pro-Trump electors. +
++++Oh, Gohmert and crew also think they're a State legislature, apparently.
+— Akiva Cohen (@AkivaMCohen) December 28, 2020 +
Plus they figured "outright lying to a federal court" was a good way to start a complaint.
No, "the State of Arizona" hasn't "appointed two competing slates of electors" pic.twitter.com/TSWxmHkkb7 +
+As Vox’s Andrew Prokop explained in December, pretend Republican electors in a handful of key swing states won by Biden did meet to cast their votes for Trump, but those votes have absolutely no legal force or substance behind them. Each state has only one valid set of electors — and those electors confirmed Biden’s Electoral College win last month, 306 to 232. +
++Gohmert, for his part, appears to be in denial: “Judge rules ‘no standing’ in my lawsuit to toss fraudulent Biden electors,” he tweeted Friday. “If I don’t have standing, no one does. When no one ever has standing, what good is a court system?” +
++And he strayed into even more dangerous territory Saturday in an appearance on the conservative cable network Newsmax, falsely claiming that if Trump is not allowed to steal the election from Biden, “it will mean the end of our republic,” and saying, “in effect, the ruling would be that you gotta go to the streets and be as violent as antifa and BLM.” +
++++Louie Gohmert on Newsmax: "But if bottom line is, the court is saying, 'We're not going to touch this. You have no remedy' -- basically, in effect, the ruling would be that you gotta go the streets and be as violent as Antifa and BLM." pic.twitter.com/cZIdGTiQls +
+— Aaron Rupar (@atrupar) January 2, 2021 +
+Gohmert’s case isn’t the first Republican election lawsuit to run into issues of legal standing — the Supreme Court rejected a wide-ranging lawsuit brought by Texas last month for the same reason — but with Inauguration Day rapidly approaching, Trump and his allies are running out of time to launch new attempts to stop Biden from taking office. +
++Biden’s inauguration doesn’t mean challenges like Gohmert’s — which, according to the Washington Post, his legal team plans to appeal — will vanish. But that doesn’t mean they stand a chance of succeeding either. +
++As University of California Irvine law professor Rick Hasen put it on Twitter last month in regard to a different lawsuit: “People ask me when the litigation is going to stop. I say perhaps not through the entire Biden presidency. But when will the serious litigation stop? It already has.” +
++Gohmert’s deeply unserious attempt at a lawsuit, however, is just one expression of the post-election mania gripping the Republican Party. And the court’s Friday ruling — which drops Trump and his Republican allies’ court record to 1-60 in post-election litigation, according to Democratic voting rights lawyer Marc Elias — won’t be the end of it. +
++Republicans in both chambers of Congress have already stated their intention to object to the certification of Biden’s Electoral College victory when lawmakers meet on January 6, and Trump, who returned to the White House early on Thursday after a holiday sojourn in Florida, has been busy promoting a rally centered on overturning the election results the same day. +
++++The BIG Protest Rally in Washington, D.C., will take place at 11.00 A.M. on January 6th. Locational details to follow. StopTheSteal! +
+— Donald J. Trump (@realDonaldTrump) January 1, 2021 +
+Needless to say, Trump’s planned rally will be utterly ineffective in challenging the election results — but that doesn’t mean it will be harmless. The last time pro-Trump protesters descended on Washington en masse, violence broke out and at least five people were stabbed. +
++And though Republicans’ efforts on the Hill are equally doomed to fail, they will ensure a protracted certification process come Tuesday. With support from at least one Republican senator guaranteed — Sen. Josh Hawley of Missouri got behind the effort on Wednesday — the GOP can temporarily hold up the process by objecting to a state’s electoral results. +
++According to Vox’s Andrew Prokop: +
++++Under this process, if at least one House member and one senator object to the results in any state, each chamber will hold a vote on the matter. For the objection to succeed, both the House and the Senate must vote in favor of it. Otherwise, it fails. (And since Democrats will control the new House, any objection to Biden’s win will surely fail in that chamber. +
+
+Failure seems a near certainty in the Senate as well. Democrats currently hold 48 seats in that chamber, and a number of Republican lawmakers have expressed disdain for Hawley’s plan. According to Politico, Alaska’s Sen. Lisa Murkowski has called it “awful;” Utah Sen. Mitt Romney said it was “disappointing and destructive;” Sen. Roger Wicker of Mississippi said, “I don’t think it’s a good idea;” and Nebraska’s Sen. Ben Sasse said, “Adults don’t point a loaded gun at the heart of legitimate self-government.” +
++New York magazine’s Olivia Nuzzi reported Friday that a GOP official said senators have been so openly angry with Hawley “because they think he knows better. As the official put it: ‘He’s not some moron like Louie Gohmert.’” +
++That isn’t to say Hawley won’t get some support: According to a CBS report on Saturday, as many as a dozen Republican senators, including three new members, might join Hawley in objecting. These senators reportedly include: Texas’s Sen. Ted Cruz, Oklahoma’s Sen. James Lankford, and Alabama’s incoming Sen. Tommy Tuberville. +
++Overall, though, according to Senate Majority Whip John Thune, the effort will “go down like a shot dog” in the Senate. +
++Senate Majority Leader Mitch McConnell also opposes the effort — but according to Gohmert, as many as 140 Republican representatives plan to object to the vote totals in the House. +
++As Prokop points out, none of this will work out for the GOP. Regardless of what further undemocratic hijinks may be planned, Biden won the presidency, and his win will be confirmed again on January 6. +
++The efforts of Gohmert, Hawley, and other Trump allies do, however, underscore a continued and dangerous unwillingness on the part of a major US political party to accept the results of a free and fair election — and the corrosive effect that might have on democracy is cause for concern, regardless of how successful their efforts are. +
+Kento Momota tests positive for COVID-19, Japan to miss Thailand Open - An association official confirmed that none of the other 22 Japan players tested positive, but said the entire team would withdraw nonetheless
Full Indian squad, including isolated five, travelling to Sydney together; Brisbane Test on as of now - For BCCI, the man under scanner is administrative manager Girish Dongre.
Sourav Ganguly health improves, tests negative for COVID-19 - The BCCI president was admitted to the Woodlands Hospital in Kolkata on Saturday.
Ajinkya Rahane is born to lead: Chappell - Ian Chappell says, “Rahane is calm when things could easily get out of hand.”
Aus vs Ind third Test | Rain washes out India’s practice session at MCG on Sunday - Both the Indian and Australian players are scheduled to leave for Sydney on Monday.
COVID-19 vaccine skeptics playing into hands of vested interests: Nadda - The BJP chief, hitting back at opposition leaders, said they refused to be proud of ‘anything Indian’
Durga ‘Bhabhi’ and Maulvi Liaquat to get their due at the Allahabad Museum - ₹8 crore project for ‘one of its kind’ Azad Gallery will tell the story of revolutionaries in the Indian freedom movement.
Bilara villagers mobilise against addiction - In a unique campaign, residents of Lamba have imposed boycott and penalties on trade of drugs, alcohol and tobacco products
Centre suspends Hindustan Newsprint Limited MD - Order follows a Central Vigilance Commission probe against him
Drop plans to privatise defence sector units, BMS urges Centre - ‘Pay dearness allowance to Central government employees immediately’
France: More than 2,500 break virus restrictions at illegal rave - The New Year's Eve event, held in a warehouse in a village in Brittany, was shut down on Saturday.
Norway landslide: More bodies found as rescuers search Gjerdrum site - Four bodies have now been recovered following the landslide that destroyed homes in Ask village.
Brexit: New era for UK as it completes separation from European Union - Boris Johnson celebrates the "freedom in our hands" as the long Brexit process comes to a conclusion.
Paris St-Germain: Mauricio Pochettino replaces Thomas Tuchel as head coach - Former Tottenham boss Mauricio Pochettino is named Paris St-Germain boss following Thomas Tuchel's sacking.
Pierre Cardin: French fashion designer buried in Paris - The renowned designer was buried in a private ceremony at Paris's Montmartre Cemetery on Saturday.
Tesla delivered a record 500,000 vehicles in 2020 - Tesla needs to expand rapidly to justify its $600 billion market capitalization. - link
Archaeology is going digital to harness the power of Big Data - Combining traditional "pick and trowel" field work with a sweeping birds-eye view - link
You can’t unsee Tedlexa, the Internet of Things/AI bear of your nightmares - From the archives: Teddy Ruxpin + Arduino + Raspberry Pi + Alexa = What could go wrong? - link
Pandemic shaming can backfire—here’s a better way - Opinion: If we can’t expect people to avoid risk, we should embrace harm reduction. - link
How electric lighting changed our sleep, and other stories in materials science - Author and science evangelist Ainissa Ramirez discusses her book, The Alchemy of Us - link
+That sail has shipped. +
+ submitted by /u/timthedriller
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+.
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+
+I’ve had amnesia for as long as I can remember. +
++What do you call a cheap circumcision? A ripoff. +
++French tanks have five reverse gears, and one that goes forward in case they’re attacked from behind. +
++My last relationship ended because I didn’t open the car door for her. I just swam for the surface. +
++My mom’s had a moment of clarity. She called me a son of a bitch. +
++I don’t trust anything that bleeds for five days straight and doesn’t die. +
++I used to finish my sentences, but now... +
++My therapist told me I’m too indecisive, but I’m not so sure. +
++I bought a terrible thesaurus yesterday, not only was it terrible, it was terrible! +
++Why do we call ourselves pirates? Because we arrr! +
++I intend to live forever. So far, so good! +
++When life gives you melons, you might be dyslexic. +
++Evening news is where they start with ‘Good evening’ and then tell you why it’s not. +
++I hate Russian dolls, they are so full of themselves. +
++There’s no ‘I’ in ‘denial’. +
++My wife and I were happy for 20 years, before we met. +
++I love my wife so much that if we were an a sinking boat, and there was only one life jacket, I would really miss her and think of her a lot. +
++The other day, my wife started a conversation by suddenly blurting out: “You haven’t listened to a word I’ve said, have you?” +
++My wife told me our neighbor kisses his wife goodbye on the steps every morning, and asked me why I don’t do the same, but I don’t know her that well. +
++Religious differences destroyed our marriage. I wasn’t allowed to love my neighbor. +
++I divorced my wife because she was too loud in bed. I could hear her from two houses down the street. +
++Yo mama so ugly, a blowjob from her counts as anal. +
++Yo mama so fat, last time she passed by the TV, I missed a season of ‘Friends’. +
+——— Edit: An unforeseen consequence of ending the post with a couple YoMamas is that an overwhelming amount of comments have been yo mama jokes. If you feel inclined to post one too, I suggest that you do as I did yesterday, and join r/YoMamaJokes. They obviously have too few members compared to the popularity of these jokes! ———
+ submitted by /u/BinBender
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+The officer asks, "Did you know you were driving at 75 mph?" +
++Heisenberg sighs, "Oh great, now we're lost." +
++The cop is unhappy, and checks the car's trunk. He asks, "And why is there a dead cat in here?" +
++Schroedinger grumbles, "Well there is NOW!" +
+ submitted by /u/aflashingstar
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+While sipping his wine, he noticed a sizzling, scrumptious looking platter being served at the next table. Not only did it look good, the smell was wonderful. +
++He asked the waiter, “What is that you just served?” +
++The waiter replied, “Si senor, you have excellent taste! Those are called Cojones de Toro, bull's testicles from the bull fight this morning. A delicacy!” +
++The cowboy said, “What the heck, bring me an order.” +
++The waiter replied, “I am so sorry senor. There is only one serving per day because there is only one bull fight each morning.” +
++If you come early and place your order, we will be sure to save you this delicacy.' +
++The next morning, the cowboy returned, placed his order, and that evening was served the one and only special delicacy of the day. +
++After a few bites, inspecting his platter, he called to the waiter and said, “These are delicious, but they are much, much smaller than the ones I saw you serve yesterday.” +
++The waiter shrugged his shoulders and replied, “Si,Senor. Sometimes the bull wins." +
+ submitted by /u/ephmal
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+All the slides were just pictures of me. +
+ submitted by /u/porichoygupto
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