From 4aab0f570adfddb59acffdd107ceb32189d1c94f Mon Sep 17 00:00:00 2001
From: Navan Chauhan <navanchauhan@gmail.com>
Date: Tue, 8 Dec 2020 00:07:45 +0530
Subject: [PATCH] added for 8th

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+  <title>08 December, 2020</title>
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+<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
+<body>
+<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
+<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
+<ul>
+<li><a href="#from-preprints">From Preprints</a></li>
+<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
+<li><a href="#from-pubmed">From PubMed</a></li>
+<li><a href="#from-patent-search">From Patent Search</a></li>
+</ul>
+<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
+<ul>
+<li><strong>Evaluation of the accuracy and ease-of-use of Abbott PanBio - A WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Background: Diagnostics are essential for controlling the pandemic. Identifying a reliable and fast diagnostic is needed to support testing. We assessed performance and ease-of-use of the Abbott PanBio antigen-detecting rapid diagnostic test (Ag-RDT). Methods: This prospective, multi-centre diagnostic accuracy study enrolled at two sites in Germany. Following routine testing with RT-PCR, a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to cycle-threshold values, days of symptoms, disease severity and study site. Additionally, an ease-of-use assessment and System Usability Scale (SUS) were performed. Findings: 1108 participants were enrolled between Sept 28 and Oct 30, 2020. Of these, 106 (9.6%) were PCR-positive. The Abbott PanBio detected 92/106 PCR-positive participants with a sensitivity of 86.8% (95% CI: 79.0% - 92.0%) and a specificity of 99.9% (95% CI: 99.4%-100%). The sub analyses indicated that sensitivity was 95.8% in CT-values &lt;25 and within the first seven days from symptom onset. The test was characterized as easy to use (SUS: 86/100) and considered suitable for point-of-care settings. Interpretation: The Abbott PanBio Ag-RDT performs well for SARS-CoV-2 testing in this large manufacturer independent study, confirming its WHO recommendation for Emergency Use in settings with limited resources. Funding: The Foundation of Innovative New Diagnostics supplied the test kits for the study. The internal funds from the Heidelberg University as well as the Charité Berlin supported this study.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.27.20239699v2" target="_blank">Evaluation of the accuracy and ease-of-use of Abbott PanBio - A WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2</a>
+</div></li>
+<li><strong>Mortality of the COVID-19 outbreak in Sweden in relation to previous severe disease outbreaks</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Influenza viruses have caused disease outbreaks in human societies for a long time. Influenza often has rapid onset and relatively short duration, both in the individual and in the population. The case fatality rate varies for different strains of the virus, as do the effects on total mortality. Outbreaks related to coronavirus infections have recently become a global concern but much less is known about the dynamics of these outbreaks and their effects on mortality. In this work, disease outbreaks in Sweden, in the time period of 1860-2020, are characterized and compared to the currently ongoing COVID-19 outbreak. The focus is on outbreaks with a sharp increase in all-cause mortality. Outbreak onset is defined as the time point when deaths counts starts to increase consistently for a period of 10 days. The duration of the outbreak is defined as the time period in which mortality rates are elevated. Excess mortality is estimated by standard methods. In total there were 15 outbreaks detected in the time period, the first 14 were likely caused by influenza virus infections, the last by SARS-CoV-2. The mortality dynamics of the SARS-CoV-2 outbreak is shown to be similar to outbreaks due to influenza virus, and in terms of the number of excess deaths, it is the worst outbreak in Sweden since the ‘Spanish flu’ of 1918-1919.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.05.22.20110320v3" target="_blank">Mortality of the COVID-19 outbreak in Sweden in relation to previous severe disease outbreaks</a>
+</div></li>
+<li><strong>Giving birth under hospital visitor restrictions: Heightened acute stress in childbirth in COVID-19 positive women</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+As the novel coronavirus (COVID-19) has spread globally, a significant portion of women have undergone childbirth while possibly infected with the virus and also under social isolation due to hospital visitor restrictions. Emerging studies examined birth outcomes in COVID-19 positive women, but knowledge of the psychological experience of childbirth remains lacking. This study survey concerning childbirth and mental health launched during the first wave of the pandemic in the US. Women reporting confirmed/suspected COVID-19 during childbirth were matched on various background factors with women reporting COVID-19 negative. We found higher prevalence of clinically significant acute stress in birth in COVID-19 positive women. This group was 11 times as likely to have no visitors than matched controls and reported higher levels of pain in delivery, lower newborn weights, and more infant admission to neonatal intensive care units. Visitor restrictions were associated with these birth outcomes. COVID-19 positive women with no visitors were 6 times as likely to report clinical acute stress in birth than COVID-19 positive women with visitors. The findings underscore increased risk for childbirth-induced psychological morbidity in COVID-19-affected populations. As hospitals continue to revise policies concerning visitor restrictions, attention to the wellbeing of new mothers is warranted.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.30.20241026v2" target="_blank">Giving birth under hospital visitor restrictions: Heightened acute stress in childbirth in COVID-19 positive women</a>
+</div></li>
+<li><strong>Model-informed COVID-19 vaccine prioritization strategies by age and serostatus</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Limited initial supply of SARS-CoV-2 vaccine raises the question of how to prioritize available doses. Here, we used a mathematical model to compare five age-stratified prioritization strategies. A highly effective transmission-blocking vaccine prioritized to adults ages 20-49 years minimized cumulative incidence, but mortality and years of life lost were minimized in most scenarios when the vaccine was prioritized to adults over 60 years old. Use of individual-level serological tests to redirect doses to seronegative individuals improved the marginal impact of each dose while partially addressing existing inequities in COVID-19 impact. While maximum impact prioritization strategies were broadly consistent across countries, transmission rates, vaccination rollout speeds, and estimates of naturally acquired immunity, this framework can be used to compare impacts of prioritization strategies across contexts.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.09.08.20190629v2" target="_blank">Model-informed COVID-19 vaccine prioritization strategies by age and serostatus</a>
+</div></li>
+<li><strong>Effects of Covid-19 lockdown on parental functioning in vulnerable families</strong> -
+<div>
+The Covid-19 pandemic has caused major changes to family life followed by a call for knowledge about how these changes have affected parental functioning, particularly in vulnerable families (Prime, Wade &amp; Brooks, 2020). This study uses a natural experiment design to investigate the effect of the Covid-19 lockdown on parental mental health, parenting stress and three dimensions of destructive interparental conflict in a heterogeneous sample characterized by pre-existing relationship problems. Results from mixed model regression analyses showed that despite significantly higher levels of parenting stress in the lockdown group (n = 744 families) compared with the control group (n = 427 families), lockdown did not adversely affect parental mental health or levels of destructive conflicts behaviors. In fact, levels of verbal aggression and child involvement in conflict decreased during lockdown among parents living apart. Pre-existing destructive conflict levels, financial problems and age of youngest child did not moderate any of the associations. Thus, findings indicated that pre-existing family vulnerability did not predispose for reduced parental functioning during lockdown, beyond increased parenting stress. Resilient processes and an increased sense of purpose may be potential mechanisms. Caution should be taken when generalizing the findings due to the welfare context of the sample and as long-term lockdown effects were not investigated. Importantly, children in vulnerable families may have been negatively impacted by increased family time, despite relatively stable parental functioning during lockdown.
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://psyarxiv.com/nm7te/" target="_blank">Effects of Covid-19 lockdown on parental functioning in vulnerable families</a>
+</div></li>
+<li><strong>Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites.</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+BACKGROUND. Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent responsible for Coronavirus disease 2019 (COVID-19). While SARS-CoV-2 infections are often benign, there are also severe COVID-19 cases, characterized by severe bilobar pneumonia that can decompensate to an acute respiratory distress syndrome, notably characterized by increased inflammation and a cytokine storm. While there is no cure against severe COVID-19 cases, some treatments significantly decrease the severity of the disease, notably aspirin and dexamethasone, which both directly or indirectly target the biosynthesis (and effects) of numerous bioactive lipids. OBJECTIVE. Our working hypothesis was that severe COVID-19 cases necessitating mechanical ventilation were characterized by increased bioactive lipid levels modulating lung inflammation. We thus quantitated several lung bioactive lipids using liquid chromatography combined to tandem mass spectrometry. RESULTS. We performed an exhaustive assessment of the lipid content of bronchoalveolar lavages from 25 healthy controls and 33 COVID-19 patients necessitating mechanical ventilation. Severe COVID-19 patients were characterized by increased fatty acid levels as well as an accompanying inflammatory lipid storm. As such, most quantified bioactive lipids were heavily increased. There was a predominance of cyclooxygenase metabolites, notably TXB2 &gt;&gt; PGE2 ≈ 12-HHTrE &gt; PGD2. Leukotrienes were also increased, notably LTB4, 20-COOH-LTB4, LTE4, and eoxin E4. 15-lipoxygenase metabolites derived from linoleic, arachidonic, eicosapentaenoic and docosahexaenoic acids were also increased. Finally yet importantly, specialized pro-resolving mediators, notably lipoxin A4 and the D-series resolvins, were also found at important levels, underscoring that the lipid storm occurring in severe SARS-CoV-2 infections involves pro- and anti-inflammatory lipids. CONCLUSIONS. Our data unmask the important lipid storm occurring in the lungs of patients afflicted with severe COVID-19. We discuss which clinically available drugs could be helpful at modulating the lipidome we observed in the hope of minimizing the deleterious effects of pro-inflammatory lipids and enhancing the effects of anti-inflammatory and/or pro-resolving lipids.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.04.20242115v1" target="_blank">Lipid storm within the lungs of severe COVID-19 patients: Extensive levels of cyclooxygenase and lipoxygenase-derived inflammatory metabolites.</a>
+</div></li>
+<li><strong>Decontamination of Common Healthcare Facility Surfaces Contaminated with SARS-CoV-2 using Peracetic Acid Dry Fogging</strong> -
+<div>
+Background: The SARS-Cov-2 pandemic has highlighted the urgent need for safe and effective surface decontamination methods, particularly in healthcare settings. Methods: The effectiveness of peracetic acid (PAA) dry fogging in decontaminating common healthcare setting surfaces was evaluated after experimentally contaminating nine surfaces (stainless steel, latex painted wood, unsealed hardwood, melamine countertop, vinyl flooring, clear plastic, faux leather, computer keyboard button and smartphone touch screen) with more than 106 TCID50 of SARS-CoV-2. Results: When fumigated with PAA dry fog for an hour, no infectious SARS-CoV-2 virus was recovered from experimentally inoculated coupons of representing nine different surface types. In contrast, high titer recovery of infectious virus was demonstrated for corresponding untreated drying controls of the same materials. Conclusion: Standard surface decontaminating processes, including sprays and wipes, are laborious and often cannot completely decontaminate sensitive electronic equipment. The ease of use, low cost and overall effectiveness of a PAA dry fogging suggest it should be considered for decontaminating settings, particularly intensive care units where severely ill SARS-CoV-2 patients are cared for.
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.04.412585v1" target="_blank">Decontamination of Common Healthcare Facility Surfaces Contaminated with SARS-CoV-2 using Peracetic Acid Dry Fogging</a>
+</div></li>
+<li><strong>Use of Public Data to Describe COVID-19 Contact Tracing in China during January 20-February 29, 2020</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+OBJECTIVE: Although contact tracing is generally not used to control influenza pandemics, China and several countries in the Western Pacific Region employed contact tracing as part of COVID-19 response activities. To improve understanding on the use of contact tracing for COVID-19 emergency public health response activities, we describe reported COVID-19 contacts traced and quarantined in China and a proxy for number of reported contacts traced per reported case. METHODS: We abstracted publicly available online aggregate data reported from China9s National Health Commission and provincial health commissions9 COVID-19 daily situational reports for January 20-February 29, 2020. The number of new contacts traced by report date was computed as the difference between total contacts traced on consecutive reports. A proxy for the number of contacts traced per case was computed as the number of new contacts traced divided by the number of new cases. RESULTS: During January 20-February 29, 2020, China reported 80,968 new COVID-19 cases (Hubei Province = 67,608 [83%]), and 659,899 contacts traced (Hubei Province = 265,617 [40%]). Non-Hubei provinces reported more contacts traced per case than Hubei Province; this difference increased over time. DISCUSSION: Along with other NPI used in China, contact tracing likely contributed to reducing SARS-CoV-2 transmission by quarantining a large number of potentially infected contacts. Despite reporting only 15% of total cases, non-Hubei provinces had 1.5 times more reported contacts traced compared to Hubei Province. Contract tracing may have been more complete in areas and periods with lower case counts.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.04.20243972v1" target="_blank">Use of Public Data to Describe COVID-19 Contact Tracing in China during January 20-February 29, 2020</a>
+</div></li>
+<li><strong>Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with professional-collected anterior nasal versus nasopharyngeal swab</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+<b>Background:</b> Nasopharyngeal (NP) swab samples for antigen-detecting rapid diagnostic tests (Ag-RDTs) require qualified healthcare professionals and are frequently perceived as uncomfortable by patients. <b>Methods:</b> We performed a manufacturer-independent, prospective diagnostic accuracy study, comparing professional-collected anterior nasal (AN) to nasopharyngeal swab, using the test kits of a WHO-listed SARS-CoV-2 Ag-RDT (STANDARD Q COVID-19 Ag Test, SD Biosensor), which is also being distributed by Roche. Individuals with high suspicion for COVID-19 infection were tested. The reference standard was RT-PCR using a combined oro-/nasopharyngeal swab sample. Percent positive and negative agreement, as well as sensitivity and specificity were calculated. <b>Results:</b> Among the 179 participants, 41 (22.9%) tested positive for SARS-CoV-2 by RT-PCR. The positive percent agreement of the two different sampling techniques for the Ag-RDT was 93.5% (CI 79.3-98.2). The negative percent agreement was 95.9% (CI 91.4-98.1). The Ag-RDT with AN-sampling showed a sensitivity of 80.5% (33/41 PCR positives detected; CI 66.0-89.8) and specificity of 98.6% (CI 94.9-99.6) compared to RT-PCR. The sensitivity with NP-sampling was 73.2% (30/41 PCR positives detected; CI 58.1-84.3) and specificity was 99.3% (CI 96.0-100). In patients with high viral load (&gt;7.0 log10 RNA SARS-CoV2/swab), the sensitivity of the Ag-RDT with AN-sampling was 100% and 94.7% with NP-sampling. <b>Conclusion:</b> This study demonstrates that sensitivity of a WHO-listed SARS-CoV-2 Ag-RDT using a professional AN-sampling kit is at least equal to that of the NP-sampling kit, although confidence intervals overlap. Of note, differences in the IFUs of the test procedures could have contributed to different sensitivities. AN-sampling can be performed with less training, reduces patient discomfort, and it enables scaling of antigen testing strategies. Additional studies of patient self-sampling should be considered to further facilitate the scaling-up of Ag-RDT testing.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.03.20243725v1" target="_blank">Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with professional-collected anterior nasal versus nasopharyngeal swab</a>
+</div></li>
+<li><strong>Quantifying the impact of test-trace-isolate-quarantine (TTIQ) strategies on COVID-19 transmission</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+The test-trace-isolate-quarantine (TTIQ) strategy is used to break chains of transmission during a disease outbreak. Confirmed-positive pathogen carriers are isolated from the community to prevent onward transmission and their recent close contacts are identified and pre-emptively quarantined. TTIQ, along with mask wearing and social distancing, make up the non-pharmaceutical interventions that are utilised to suppress the ongoing SARS-CoV-2 pandemic. The efficacy of the TTIQ strategy depends on the probability of isolating a case, the fraction of contacts quarantined, and the delays in these processes. Here we use empirical distributions of the timing of SARS-CoV-2 transmission to quantify how these parameters individually contribute to the reduction of onwards infection. We show that finding and isolating index cases, and doing so with minimal delay after symptom onset, have the largest effects on case reduction, and that contact tracing can make up for deficiencies in testing coverage and delays. These results can be used to assess how TTIQ can be improved and optimised. We provide an online application to assess the efficacy as a function of these parameters.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.04.20244004v1" target="_blank">Quantifying the impact of test-trace-isolate-quarantine (TTIQ) strategies on COVID-19 transmission</a>
+</div></li>
+<li><strong>Contrasting factors associated with COVID-19-related ICU and death outcomes: interpretable multivariable analyses of the UK CHESS dataset.</strong> -
+<div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Identifying factors associated with severe COVID-19 is a priority to guide clinical care and resource use in this pandemic. This cohort comprised 13954 in-patients with confirmed COVID-19. Study outcomes were death and intensive care unit admission (ICUA). Multivariable logistic regression estimated odd ratios adjusted for 37 covariates (comorbidities, demographic, and others). Gradient boosted decision tree (GBDT) classification generated Shapley values evaluating the impact of covariates for each patient. Deaths due to COVID-19 were associated with immunosuppression due to disease (Odds Ratio 1.39, 95%CI [1.10-1.76]), type-2 diabetes (1.31, [1.17-1.46]), chronic respiratory disease (1.19, [1.05-1.35]), obesity (1.16, [1.01-1.33], age (1.56/10-year increment, [1.52-1.61]), and male sex (1.54, [1.42-1.68]). Associations with ICUA differed in direction (e.g., age, chronic respiratory disease) and in scale, e.g., obesity (3.37, [2.90-3.92]) for some factors. Ethnicity was strongly but variably associated with both outcomes, for example Irish ethnicity is negatively with death but not ICUA. GBDTs had similar performance (ROC-AUC, ICUA 0.83, death 0.68 for GBDT; 0.80 and 0.68 for logistic regression). Shapley explanations overall were consistent with odds ratios. Chronic heart disease, hypertension, other comorbidities, and some ethnicities had Shapley impacts on death ranging from positive to negative among different patients, although consistently associated with ICUA for all. Immunosuppressive disease, type-2 diabetes, and chronic liver and respiratory diseases had positive impacts on death with either positive or negative on ICUA. Very different association of some factors, e.g., obesity, with death and ICUA may guide review of practice. Shapley explanation identified varying effects among patients emphasising the importance of individual patient assessment.
+</p>
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.03.20242941v1" target="_blank">Contrasting factors associated with COVID-19-related ICU and death outcomes: interpretable multivariable analyses of the UK CHESS dataset.</a>
+</div></li>
+<li><strong>COVID-19 Encephalopathy in the Context of Psychiatric Comorbidity: Case Report and Diagnostic Pitfalls</strong> -
+<div>
+We present the case of likely COVID-19 associated encephalopathy in a male in his early 50s with a history of non-psychotic depression and personality disorder who presented with delirium, new psychotic symptoms and who developed paratonia and obtundation. After initial questions of neuroleptic malignant syndrome, serotonin syndrome, and stiff person syndrome were decided to not be supported by the clinical picture, conservative management and the repeated treatment of a co-ocurring mastoiditis led to improvement of mental status, regained ability to walk and speak, though a dysexecutive syndrome was left when patient was discharged to rehabilitation services. We explore the role the patient’s psychiatric comorbidity had in terms of both his clinical course and the decisions and diagnostic considerations of the various treating teams involved.
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://osf.io/td8sj/" target="_blank">COVID-19 Encephalopathy in the Context of Psychiatric Comorbidity: Case Report and Diagnostic Pitfalls</a>
+</div></li>
+<li><strong>Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19</strong> -
+<div>
+The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the associated disease COVID-19, requires therapeutic interventions that can be rapidly translated to clinical care. Unfortunately, traditional drug discovery methods have a &gt;90% failure rate and can take 10-15 years from target identification to clinical use. In contrast, drug repurposing can significantly accelerate translation. We developed a quantitative high-throughput screen to identify efficacious single agents and combination therapies against SARS-CoV-2. Quantitative high-content morphological profiling was coupled with an AI-based machine learning strategy to classify features of cells for infection and stress. This assay detected multiple antiviral mechanisms of action (MOA), including inhibition of viral entry, propagation, and modulation of host cellular responses. From a library of 1,425 FDA-approved compounds and clinical candidates, we identified 16 dose-responsive compounds with antiviral effects. In particular, we discovered that lactoferrin is an effective inhibitor of SARS-CoV-2 infection with an IC50 of 308 nM and that it potentiates the efficacy of both remdesivir and hydroxychloroquine. Lactoferrin also stimulates an antiviral host cell response and retains inhibitory activity in iPSC-derived alveolar epithelial cells, a model for the primary site of infection. Given its safety profile in humans, these data suggest that lactoferrin is a readily translatable therapeutic adjunct for COVID-19. Additionally, several commonly prescribed drugs were found to exacerbate viral infection and warrant clinical investigation. We conclude that morphological profiling for drug repurposing is an effective strategy for the selection and optimization of drugs and drug combinations as viable therapeutic options for COVID-19 pandemic and other emerging infectious diseases.
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.05.27.117184v4" target="_blank">Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19</a>
+</div></li>
+<li><strong>Impact of Infectious Disease Risk Perception on Perceived Retail Crowding: With Special Reference to Retail Industry in Sri Lanka</strong> -
+<div>
+The global pandemic of COVID 19 has changed consumer behaviour to reduce the risk. This is common for all interpersonal interactions of individuals especially in maintaining the recommended interpersonal distance based on the recommendations from the health experts. Sri Lanka as a developing country affected by COVID 19, observed changes in individuals’ day today’ consumption decision making due to pandemic. Importantly the retailing sector is highly influenced by the conditions since the frequency of interpersonal interactions and degree of interaction is higher in the retailing sector. Interestingly the retailing sector with its largest contributor, the SMEs need to identify the unique changes that happen to the consumer behaviour in responding to them. Accordingly, the objective of the study is to examine the impact of infectious disease risk on the perceived retail crowding in two perspectives of human density and the spatial density. The study has used a quantitative survey in collecting data with the online self-administrated questionnaire with a sample of 100 consumers. Data analysis has been done by using a PLS-SEM with the support of SmartPLS version 3. The key findings of the study emphasize the significant positive influence of infectious disease risk on human density as well as on the spatial density. Based on the findings the study attempts to provide the implications for the retailing industry to cope with situational changes in the environment.
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://osf.io/srknd/" target="_blank">Impact of Infectious Disease Risk Perception on Perceived Retail Crowding: With Special Reference to Retail Industry in Sri Lanka</a>
+</div></li>
+<li><strong>Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus in vitro</strong> -
+<div>
+Many plant juices, extracts and teas have been shown to possess antiviral activity. We here analyzed the virucidal activity of black chokeberry (Aronia melanocarpa), pomegranate (Punica granatum), and elderberry (Sambucus nigra) juice, as well as green tea (Camellia sinensis) against different respiratory viruses. We found that all tested plant derived products effectively inactivated influenza virus, whereas only chokeberry juice diminished SARS-CoV-2 and vaccinia virus infectivity. None of the products inactivated non-enveloped human adenovirus type 5. Thus, black chokeberry juice exerts virucidal activity against different enveloped viral pathogens under in vitro conditions. Whether application of virucidal juices or green tea as oral rinses may lower viral loads in the oral cavity in vivo remains to be evaluated.
+</div>
+<div class="article-link article-html-link">
+🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.10.30.360545v2" target="_blank">Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus in vitro</a>
+</div></li>
+</ul>
+<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
+<ul>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase II / III Study of COVID-19 DNA Vaccine (AG0302-COVID19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Group A (AG0302-COVID19);   Biological: Group A (Placebo);   Biological: Group B (AG0302-COVID19);   Biological: Group B (Placebo)<br/><b>Sponsors</b>:   AnGes, Inc.;   Japan Agency for Medical Research and Development<br/><b>Recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Convalescent Plasma for Treatment of COVID-19: An Open Randomised Controlled Trial</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: SARS-CoV-2 convalescent plasma;   Other: Standard of care<br/><b>Sponsors</b>:   Joakim Dillner;   Karolinska Institutet;   Danderyd Hospital;   Falu Hospital<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>At-Home Infusion Using Bamlanivimab in Participants With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: bamlanivimab<br/><b>Sponsors</b>:   Daniel Griffin, MD PhD;   Eli Lilly and Company;   Optum, Inc.<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ivermectin for Severe COVID-19 Management</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ivermectin<br/><b>Sponsors</b>:   Afyonkarahisar Health Sciences University;   NeuTec Pharma<br/><b>Completed</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 And Geko Evaluation: The CAGE Study</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Device: geko T3<br/><b>Sponsor</b>:   Lawson Health Research Institute<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase Ⅱ Clinical Trial of Recombinant Corona Virus Disease-19 (COVID-19) Vaccine (Sf9 Cells)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) &amp; Two dose regimen;   Biological: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) &amp; Three dose regimen;   Biological: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) &amp; Two dose regimen;   Biological: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (18-59 years) &amp; Three dose regimen;   Biological: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) &amp; Two dose regimen;   Biological: Low-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) &amp; Three dose regimen;   Biological: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) &amp; Two dose regimen;   Biological: High-dose Recombinant COVID-19 vaccine (Sf9 cells) (60-85 years) &amp; Three dose regimen;   Biological: Low-dose placebo (18-59 years) &amp; Two dose regimen;   Biological: Low-dose placebo (18-59 years) &amp; Three dose regimen;   Biological: High-dose placebo (18-59 years) &amp; Two dose regimen;   Biological: High-dose placebo (18-59 years) &amp; Three dose regimen;   Biological: Low-dose placebo (60-85 years) &amp; Two dose regimen;   Biological: Low-dose placebo (60-85 years) &amp; Three dose regimen;   Biological: High-dose placebo (60-85 years) &amp; Two dose regimen;   Biological: High-dose placebo (60-85 years) &amp; Three dose regimen<br/><b>Sponsors</b>:   Jiangsu Province Centers for Disease Control and Prevention;   West China Hospital<br/><b>Recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>LYT-100 in Post-acute COVID-19 Respiratory Disease</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: LYT-100;   Other: Placebo<br/><b>Sponsors</b>:   PureTech;   Clinipace Worldwide;   Novotech (Australia) Pty Limited<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Adaptive COVID-19 Treatment Trial 4 (ACTT-4)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Baricitinib;   Drug: Dexamethasone;   Other: Placebo;   Drug: Remdesivir<br/><b>Sponsor</b>:   National Institute of Allergy and Infectious Diseases (NIAID)<br/><b>Recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids -</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Omegaven®;   Drug: Sodium chloride<br/><b>Sponsor</b>:   Karolinska University Hospital<br/><b>Recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>WHO COVID-19 Solidarity Trial for COVID-19 Treatments</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Remdesivir;   Drug: Acalabrutinib;   Drug: Interferon beta-1a;   Other: Standard of Care<br/><b>Sponsor</b>:   The University of The West Indies<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vitamin D and Zinc Supplementation for Improving Treatment Outcomes Among COVID-19 Patients in India</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: Vitamin D3 (cholecalciferol);   Dietary Supplement: Zinc (zinc gluconate);   Dietary Supplement: Zinc (zinc gluconate) &amp; Vitamin D (cholecalciferol);   Other: Placebo<br/><b>Sponsors</b>:   Harvard School of Public Health;   Foundation for Medical Research;   University Health Network, Toronto<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Apixaban 2.5 MG;   Drug: Placebo<br/><b>Sponsors</b>:   Thomas Ortel, M.D., Ph.D.;   National Heart, Lung, and Blood Institute (NHLBI)<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Urine Alkalinisation to Prevent AKI in COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Sodium Bicarbonate 150Meq/L/D5W Inj<br/><b>Sponsor</b>:   Guy’s and St Thomas’ NHS Foundation Trust<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of Ovotransferrin in COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Dietary Supplement: Ovotransferrin<br/><b>Sponsor</b>:   Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo<br/><b>Not yet recruiting</b></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Assessing Safety, Hospitalization and Efficacy of rNAPc2 in COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: rNAPc2;   Drug: Heparin<br/><b>Sponsors</b>:   ARCA Biopharma, Inc.;   Colorado Prevention Center<br/><b>Not yet recruiting</b></p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
+<ul>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors</strong> - The COVID-19 pathogen, SARS-CoV-2, requires its main protease (SC2M Pro ) to digest two of its translated polypeptides to form a number of mature proteins that are essential for viral replication and pathogenesis. Inhibition of this vital proteolytic process is effective in preventing the virus from replication in infected cells and therefore provides a potential COVID-19 treatment option. Guided by previous medicinal chemistry studies about SARS-CoV-1 main protease (SC1M Pro ), we have designed…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 RNA in Wastewater Settled Solids Is Associated with COVID-19 Cases in a Large Urban Sewershed</strong> - Wastewater-based epidemiology may be useful for informing public health response to viral diseases like COVID-19 caused by SARS-CoV-2. We quantified SARS-CoV-2 RNA in wastewater influent and primary settled solids in two wastewater treatment plants to inform the preanalytical and analytical approaches and to assess whether influent or solids harbored more viral targets. The primary settled solids samples resulted in higher SARS-CoV-2 detection frequencies than the corresponding influent samples….</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase</strong> - COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is currently being treated using Remdesivir, a nucleoside analog that inhibits the RNA-dependent-RNA polymerase (RdRp). However, the enzymatic mechanism and efficiency of Remdesivir have not been determined, and reliable screens for new inhibitors are urgently needed. Here we present our work to optimize expression in E. coli, followed by purification and kinetic analysis of an untagged NSP12/7/8 RdRp…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Need for Ocular Protection for Health Care Workers During SARS-CoV-2 Outbreak and a Hypothesis for a Potential Personal Protective Equipment</strong> - SARS-CoV-2 is a coronavirus with high infectivity and has caused dramatic pressure on health systems all over the world. Appropriate personal protection for medical staffs is critical. For ocular protection, there is ongoing hot debate and concern for potential ocular transmission of SARS-CoV-2. Ocular manifestations and positive detection of viral RNA in ocular samples were only reported in very small number of patients infected with SARS-CoV-2. However, health care workers need to face…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Improved protection of filtering facepiece through inactivation of pathogens by hypertonic salt solutions - A possible COVID-19 prevention device</strong> - The filtering facepiece operates through filtration without the ability to kill the viruses. If the filtration might be combined with antiviral agents simultaneously in the masks, this would be much more efficient during the use of these masks and against cross-infection after being discarded. For centuries, sodium chloride (NaCl) contributes to inhibiting pathogens on various occasions. If aerosol with infectious agents reaches the filtering face-piecé surface of the filtering face-piece,…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Micro-RNAs in the regulation of immune response against SARS COV-2 and other viral infections</strong> - BACKGROUND: Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18-24 nucleotide length RNA molecules. Recently, miRNAs have been viewed as important modulators of viral infections they can function as suppressors of gene expression by targeting cellular or viral RNAs during infection.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Unusual association of COVID-19, pulmonary tuberculosis and human immunodeficiency virus, having progressed favorably under treatment with chloroquine and rifampin</strong> - Infection with the new coronavirus has been declared an international health emergency. Its curative treatment is unknown and is the subject of several clinical trials. In addition, the concomitant association of COVID-19 with tuberculosis and the human immunodeficiency virus, hitherto never described, is potentially fatal. We report the illustrative case of a 32-year-old patient who presented this trifecta of infections and who did well under treatment with chloroquine and anti-mycobacterial…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Impacts, Diagnosis and Possible Therapeutic Techniques: A Comprehensive Review</strong> - BACKGROUND: The spread of COVID-19 has become growing cause of mortalities over the globe since its major outbreak in December 2019. The scientific and medical communities are rallying to study different strains and probable mutations to develop more rapid and reliable molecular diagnostic tests and possible therapeutic approaches for SARSCoV-2.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neutrophil more than platelet activation associates with thrombotic complications in COVID-19 patients</strong> - CONCLUSIONS: Platelet and neutrophil activation are key features of COVID-19 patients. NET biomarkers may help to predict clinical worsening and VTE, and may guide LMWH-treatment intensity.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A five day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness</strong> - Ivermectin, an FDA-approved anti-parasitic agent, was found in vitro to inhibit SARS-CoV-2 replication. To determine the rapidity of viral clearance and safety of ivermectin among adult SARS-CoV-2 patients we conducted a randomized, double-blind, placebo-controlled trial of oral ivermectin alone (12 mg once daily for 5 days) or in combination with doxycycline (12 mg ivermectin single dose and 200 mg stat doxycycline day-1 followed by 100 mg 12hrly for next 4 days) compared with placebo among 72…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease</strong> - The disease, COVID-19, is caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) for which there is currently no treatment. The SARS-CoV-2 main protease (M^(pro)) is an important enzyme for viral replication. Small molecules that inhibit this protease could lead to an effective COVID-19 treatment. The 2-pyridone scaffold was previously identified as a possible key pharmacophore to inhibit SARS-CoV-2 M^(pro). A search for natural, antimicrobial products with the 2-pyridone moiety was…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synergism of TNF-alpha and IFN-gamma Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes</strong> - COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute lung damage associated with patient mortality. While multiple inflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection, we found that only the combination of TNF-α and IFN-γ induced inflammatory cell death characterized by inflammatory cell death, PANoptosis. Mechanistically, TNF-α and IFN-γ co-treatment activated the JAK/STAT1/IRF1 axis, inducing nitric oxide production and…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells</strong> - In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no specific and effective drugs for treating this disease have been reported until today. Angiotensin-converting enzyme 2 (ACE2), a receptor of SARS-CoV-2, mediates the virus infection by binding to spike protein. Although ACE2 is expressed in the lung, kidney, and intestine, its expressing levels are rather low, especially in the lung. Considering the great infectivity of COVID-19, we speculate that…</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Proton pump inhibitor or famotidine use and severe COVID-19 disease: a propensity score-matched territory-wide study</strong> - No abstract</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program</strong> - Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still remain poorly understood. Herein we demonstrated that lungs originated from different types of PF patients including coronavirus disease 2019, systemic sclerosis associated interstitial lung disease and idiopathic pulmonary fibrosis, and mice following bleomycin (BLM)-induced PF are characterized by the altered methyl-CpG-binding domain 2 (MBD2) expression in macrophages. Depletion of Mbd2 in macrophages…</p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
+<ul>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AN EFFICIENT METHODOLOGY TO MANAGE THE ADMISSIONS IN HOSPITALS DURING THE PANDEMICS SUCH AS COVID 19</strong> -</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiinfektive Arzneiform zur Herstellung einer Nasenspülung gegen COVID-19</strong> -</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Einzeldosierte, wasserlösliche oder wassermischbare Arzneiform, umfassend mindestens einen antiinfektiven Arzneistoff, zur Herstellung einer Nasenspülung und/oder zur Verwendung in der lokalen Behandlung des menschlichen Nasenraums.</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiinfektive Arzneiform zur Herstellung einer Nasenspülung gegen COVID-19</strong> -</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Einzeldosierte, wasserlösliche oder wassermischbare Arzneiform, umfassend mindestens einen antiinfektiven Arzneistoff, zur Herstellung einer Nasenspülung und/oder zur Verwendung in der lokalen Behandlung des menschlichen Nasenraums.</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A medicine for treating coronavirus-2 infection</strong> - The invention discloses a medicine for treating coronavirus-2 infection. The invention finds that T cells in COVID-19 patients is reduced and depleted finally, indicating that cytokines such as IL-10, IL-6, TNF-a may directly mediate reduction of T cells. Therefore, ICU patients need new treatment measures, and may even high-risk patients with low T cells count require early preventive treatment.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>疫情趋势预测方法、装置、电子设备及存储介质</strong> - 本申请实施例提供了一种疫情趋势预测方法、装置、电子设备及存储介质，应用于医疗科技领域，该电子设备包括处理器和存储器，存储器用于存储计算机程序，计算机程序包括程序指令，处理器被配置用于调用程序指令，执行以下步骤：获取目标地区的疫情序列数据；根据疫情序列数据构建疫情序列数据对应的目标特征矩阵；调用预训练的时间序列模型以根据目标特征矩阵进行疫情趋势预测，得到第一疫情趋势预测结果，第一疫情趋势预测结果包括预测的第二预设日期范围内各日期的新增病例的数量和/或新增死亡的人数。采用本申请，可以结合多维度特征来进行疫情趋势预测，可参考性更高。本申请涉及区块链技术，如可将第一疫情趋势预测结果写入区块链中。</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 예방을 위한 mRNA기반 항원보강제 혼합물 합성 방법</strong> - 본 발명은 SARS-CoV-2(코로나 바이러스) 예방을 위한 mRNA 항원보강제에 관한 것으로 코로나 바이러스에 대한 백신으로서 상기의 항원에 대한 예방을 목적으로 하고 있다. 아이디어에는 보강제에 해당하는 완전프로인트항원보강제(CFA)와 불완전프로인트항원보강제(IFA), 번역과 안정성의 최적화가 된 mRNA, mRNA 운반체, 양이온성 지질 나노입자(lipid nanoparticles)로 구성되며 기존의 백신에 비해 효율성과 안정성의 측면에서 더 향상된 효과를 가지고 있다.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A PRIMER COMBINATION FOR DETECTING 2019NCOV BY LOOP-MEDIATED ISOTHERMAL AMPLIFICATION</strong> - The invention provides a primer combination for detecting 2019nCoV by loop mediated isothermal amplification. The primer combination comprises a forward external primer NCP-F3-2 shown in SEQ ID NO.1, a reverse external primer NCP-B3 2 shown in SEQ ID NO.2, a forward inner primer NCP-FIP-2 shown in SEQ ID NO.3, a reverse inner primer NCP-BIP-2 shown in SEQ ID NO.4 and a loop primer NCP-LB 2 shown in SEQ ID No.5. The method has the advantages of short detection time, high sensitivity and strong specificity for 2019nCoV, and the detection result can be observed by naked eyes, thereby greatly improving the detection efficiency of 2019nCoV.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mittel zur Stärkung der Abwehrkräfte und Erhöhung der Immunität</strong> -</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Mittel zur Stärkung der Abwehrkräfte und Erhöhung der Immunität, insbesondere gegen eine Covid19-Infektion aufgrund des Sars-CoV-2-Virus, mit folgender Wirkstoffkombination:</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Plasma oder Serum, gewonnen aus dem Blut eines an Covid19 erkrankten und genesenen Menschens oder Tieres,</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">zumindest einem zugelassenen Medikament oder einer Kombination von zugelassenen Medikamenten und</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">zugelassenen Vitaminen und Mineralstoffe.</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vorrichtung zum Reinigen und/oder Desinfizieren von Objekten</strong> -</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Vorrichtung (1) zum Desinfizieren von Objekten mit einer Basiseinheit (2), mit einem Aufnahmebehälter (4) für Wasser, welcher an der Basiseinheit (2) montierbar und von der Basiseinheit demontierbar ist, mit einer Objekthalterung (6) zum Halten und/oder Stützen der Objekte (10), wobei diese Objekthalterung (6) in dem Aufnahmebehälter montierbar ist und mit einer elektrisch betriebenen Reinigungseinrichtung (8), welche in dem Wasser befindliche Objekte zumindest mittelbar reinigt oder desinfiziert, wobei diese Reinigungseinrichtung in der Basiseinheit befindliche Erzeugungsmittel zum Erzeugen einer elektrischen Spannung aufweist sowie einen Plasmagenerator und/oder eine Ultraschallerzeugungseinheit.</p></li>
+</ul>
+<img alt="embedded image" id="EMI-D00000"/>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
+<ul>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Methods for treating Arenaviridae and Coronaviridae virus infections</strong> - Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I:</li>
+</ul>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">wherein the ’ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.</p>
+
+
+<script>AOS.init();</script></body></html>
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+  <title>08 December, 2020</title>
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+<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
+<body>
+<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
+<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
+<ul>
+<li><a href="#from-new-yorker">From New Yorker</a></li>
+<li><a href="#from-vox">From Vox</a></li>
+<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
+<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
+<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
+<li><a href="#from-ars-technica">From Ars Technica</a></li>
+<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
+</ul>
+<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
+<ul>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Congress Must Act Now to Provide an Economic Bridge to the Coronavirus Vaccine</strong> - Unprecedented legislative action this past spring helped to stave off a Great Depression-style coronavirus downturn. The House and Senate need to act again. - <a href="https://www.newyorker.com/news/our-columnists/congress-must-act-now-to-provide-an-economic-bridge-to-the-coronavirus-vaccine">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>William Barr’s Break with Donald Trump</strong> - The Attorney General is, at long last, defending American democracy. - <a href="https://www.newyorker.com/news/daily-comment/william-barrs-break-with-donald-trump">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump’s Election-Fraud Bluster Finds an Audience</strong> - If his goal is to retain the Presidency, the effort is a historic failure. But Trump has proved able to build a significant following for his claims. - <a href="https://www.newyorker.com/news/the-political-scene/donald-trumps-election-fraud-bluster-finds-an-audience">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Donald Trump, George Wallace, and the Influence of Losers</strong> - The outgoing President may find himself stunned by the speed at which former loyalists distance themselves. But his ideological imprint on the G.O.P. is likely to remain. - <a href="https://www.newyorker.com/news/daily-comment/donald-trump-george-wallace-and-the-influence-of-losers">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Atul Gawande on Coronavirus Vaccines and Prospects for Ending the Pandemic</strong> - The New Yorker staff writer, now a member of President-elect Biden’s COVID-19 advisory board, discusses when a vaccine might be ready for distribution, who should receive it, and whether eradicating the virus is possible. - <a href="https://www.newyorker.com/news/the-new-yorker-interview/atul-gawande-on-coronavirus-vaccines-and-prospects-for-ending-the-pandemic">link</a></p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
+<ul>
+<li><strong>A less miserable winter</strong> -
+<figure>
+<img alt="a snowy, abstract sky" src="https://cdn.vox-cdn.com/thumbor/NcRoYsA108mvQYo9nUSwFtUVbUo=/750x0:5250x3375/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68470145/GettyImages_1176555074.0.jpg"/>
+<figcaption>
+Winter, even in 2020, doesn’t have to be the worst. | Getty Images/EyeEm
+</figcaption>
+</figure>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Tips on how to keep houseplants alive, pick up a hobby, exercise indoors, bake bread, and more.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YUOjDB">
+Winter is never the easiest<strong> </strong>time. It’s cold. It’s dark. It’s icy and snowy and windy. It puts the “season” in “seasonal affective disorder.”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Myh806">
+And this winter, the end of 2020 and the beginning of 2021, is extra complicated. The end of the pandemic <a href="https://www.vox.com/2020/11/30/21726327/moderna-covid-19-vaccine-results">might be in sight</a>, but we’re <a href="https://www.vox.com/2020/11/12/21560902/covid-19-risk-hospitalizations-chart-texas-illinois">not there yet</a>, not by a long shot. So we know that we won’t have all the things to look forward to that we once had: gatherings at home with family and friends, bundling up for a night out at a restaurant or bar, the relief of running on a treadmill at the gym while the streets outside are slick and dangerous. It’s going to be rough; some might even call it miserable.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5MOQeK">
+We’d like to help you make it <em>less</em> miserable. Vox has brought together some of our coziest minds — and tapped the experts — to help you figure out how to navigate this winter. Join us as we roll out tips on how to pick up a new (indoor) hobby, how to bake magical bread, and how to keep your houseplants from calling it quits. We’ll be checking with people who know how to deal with small-space living and long, dark winters. We hope it’ll help make things less terrible — maybe even a little joyful.
+</p>
+<hr class="p-entry-hr" id="9t2aB7"/>
+<h1 id="vwSZyH">
+<a href="https://www.vox.com/21507101/houseplants-alive-winter-pandemic-garden">How to keep your houseplants (and yourself) less miserable this winter</a> by Umair Irfan
+</h1>
+<figure class="e-image">
+<img alt="a illustration of many leaves and greens with a tiny pair of eyes in the darkness" src="https://cdn.vox-cdn.com/thumbor/DjMeQ-zQD2v56xCWfdwACdBZpN4=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22148668/_PLANTS.jpg"/> <cite>Sarah Lawrence for Vox</cite>
+</figure>
+<h1 id="hzsx15">
+<a href="https://www.vox.com/the-goods/21742395/winter-survival-scandinavia-norway-pandemic-seasonal-affective-disorder-darkness">A Scandinavian local explains how to make it through winter</a>, by Melinda Fakuade
+</h1>
+<figure class="e-image">
+<img alt="A small, cozy house in a wintry landscape" src="https://cdn.vox-cdn.com/thumbor/PDfjJWp9R7ArKO3vvZCHY4EL7Ss=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22148677/_NORWAY.jpg"/> <cite>Sarah Lawrence for Vox</cite>
+</figure></li>
+<li><strong>A Scandinavian local explains how to make it through winter</strong> -
+<figure>
+<img alt="A small, cozy house in a wintery landscape" src="https://cdn.vox-cdn.com/thumbor/KiEEXZxaw92fuebG5yQ1Iuf_1ws=/1249x0:5000x2813/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68470137/_NORWAY.0.jpg"/>
+<figcaption>
+In Norway, getting through the long, dark winter is a lifestyle. | Sarah Lawrence for Vox
+</figcaption>
+</figure>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Hygge, a culture of coziness that has taken over the self-care space, is Scandinavia’s specialty.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3lvCLB">
+<em>Winter will suck. We gathered some of Vox’s coziest minds to help you </em><a href="https://www.vox.com/the-goods/22154095/winter-tips-hacks-less-miserable"><em>make it suck less</em></a><em>.</em>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VOWL6q">
+Ida Skibenes, a 32-year-old born and raised in Norway, resides in Bergen, where by <a href="https://www.tripsavvy.com/weather-in-bergen-1626874">December</a>, there is an average of six hours of daylight per day. Shorter days mean more time spent inside, sheltering from the cold. But as a result, Scandinavians are familiar with the business of creating bearable winters for themselves, bringing small joys to where despair might typically occur.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SBJwG9">
+Seasonal depression affects around <a href="https://www.psychologytoday.com/us/conditions/seasonal-affective-disorder#:~:text=The%20individual%20must%20experience%20seasonal,in%20women%20than%20in%20men.">10 million Americans</a>, and winter may be even more difficult to manage for many as the pandemic continues on, and forces us to spend more time <a href="https://www.vox.com/the-highlight/21514367/coronavirus-covid-19-home-renovation-schooling-peloton">at home.</a> We could use some Norwegian advice — <a href="https://www.vox.com/the-goods/2020/1/15/21063670/hygge-self-care-domestic-cozy-marketing-brands-haus">“hygge,”</a> a culture of coziness that has taken over the self-care space, is Scandinavia’s specialty. They’ve mastered and perfected the art of making winter less miserable. Skibenes spoke to Vox about how she survives winter, and her methods to combat feelings of isolation that come with the colder months of the year.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pKKmg6">
+<strong>Tell me a little bit about your relationship with cold winters over the course of your life. Do you like winter? Do you not like winter?</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Tq96Qz">
+I think growing up here you get used to it. You kind of don’t have a choice. Of course, some people will travel south, especially the older generation who will leave for Spain or Italy for a month or two when it gets really cold and really dark. But most of us just deal with it. We are used to having many months in a row where we don’t really see that much sun or daylight.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YPLm72">
+When it’s at its darkest, I think most people will struggle a little, maybe feel a little more tired. Especially if you work in an office and you don’t have the chance to step outside and get some sunlight on your face. It can be pretty hard because it’s dark when you leave in the morning and then it’s dark when you get home.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AlHDnL">
+<strong>I struggle with how early it gets dark even in New York. Do you have any tips to combat that difficulty?</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BEseCW">
+In some ways, [I’ve experienced it.] Especially with feeling more tired than in the summer months. That might be the hardest part. But I’m a full winter girl, so I kind of appreciate the dark. I think it’s cozier to get up in the morning when it’s dark outside.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6lEd71">
+I think that the most important thing you can do is keep your sleeping rhythm the same. Try to, if you have the chance during your day, get out and get some sun. If it’s only for like ten minutes, I think it can make a huge difference. We also have really bad weather, especially in November and December. It can be very tempting to just stay inside and just hunker down and wait for it to pass, but I think it’s really important to get that fresh air and just move around a little.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BGCffd">
+In Norway, we are very much professionals when it comes to making things cozy. Lighting candles and being under a blanket on a couch and playing games, so that’s in our blood I think.
+</p>
+<figure class="e-image">
+<img alt="Aerial shot of snow on rooftops in Bergen, Norway." src="https://cdn.vox-cdn.com/thumbor/Pl72snYJkThOOL4DFFH4BhuN7zk=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22145433/GettyImages_1083346292__1_.jpg"/> <cite>Corbis via Getty Images</cite>
+<figcaption>
+A winter scene in Bergen, Norway, where Skibenes resides.
+</figcaption>
+</figure>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tJ8nPc">
+<strong>I actually wanted to ask you about that. I’ve read that the Scandinavian culture of coziness is called hygge. Can you tell me more about that?</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uovCFm">
+I think Norway may be most explicit about it. We go all in. I think maybe it’s the way that we’ve kind of learned to survive through hard winters for a long time. We find a lot of comfort in just doing the really small things to make your home a bit more cozy and just lighten the mood. And a lot of us have grown up staying in family cabins — that’s a thing, where we would go to a cabin up in the mountains or by the sea or somewhere else.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7DCdn2">
+That’s a peak level of coziness when you get to the cabin and you light the candles and play games and eat a lot of food. How it got that way, I’m not sure, but it’s just become this thing that most of us do, just a way of surviving those long months.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yP8dIM">
+<strong>So it’s kind of like this culture of togetherness and warmth; it’s kind of like a purposeful escape from the dreariness of winter.</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EBF7FS">
+I think it’s interesting because we as a people here in Norway, we’re generally quite cold. We like to keep our distance from people. On the news now with Covid-19, they [say] “What did Norway do right? What did they do that we didn’t do?” And I think that often they miss the point of us being people that really, generally don’t like being around people that much.
+</p>
+<div class="c-float-left">
+<aside id="WutxBd">
+<q>“For most of us, especially from 30 years and up, we only like being comfortable, and warm is more important than looking good”</q>
+</aside>
+</div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wrIlhG">
+We kind of just stay with the people we know and the people we love, and we don’t socialize that much with people we don’t know. Especially now during the winter months, we don’t really go that much outside anyways, so I think it’s easier for us to socially distance than other people. I think that’s a part of the coziness culture as well, that we have this kind of small group. Maybe it’s just a partner or maybe it’s a couple of friends or maybe it’s just a couple of family members that you’re really close with, and that’s your flock.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IpnEtA">
+<strong>What about the way that Norwegian people prep for the cold in the way they get dressed? Is there anything clothing-wise that you would recommend to Americans who want to make their winter less miserable or cozier?</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lcKtLH">
+We use a lot of wool. From top to bottom. Immediately, as soon as we hit the end of September, start of October, that’s when we get our wool game on. If you’re going to survive winter either in Norway or anywhere else where it’s cold, that’s the thing to do.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jeJqJ7">
+It’s important for us to stay warm throughout the day, because if you get cold then you’ll be cold for the rest of the day and you’ll be miserable. Especially socks and hats. If you’re warm on your feet and warm on your head, then you’re basically covered. Layering and always wool. The first layer is always wool.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="N1YIlo">
+<strong>When it gets really cold like December and January, I always have a million layers on. But I always feel like I look so bulky. I imagine that in Norway, people find a way to look more chic about it.</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PTajig">
+Some of us try — especially the younger generation. I don’t know how they do it, but they look flawless. But for most of us, especially from 30 years and up, we only like being comfortable, and warm is more important than looking good.
+</p>
+<div class="c-float-right">
+<aside id="8awKgP">
+<q>“I think that often they miss the point of us being people that really, generally don’t like being around people that much”</q>
+</aside>
+</div>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JEYiUP">
+<strong>And is there any way that Norwegians approach winter skin care or beauty or self-care habits that you would recommend to Americans?</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KbjyOX">
+Moisturize. I’m terrible at skincare in general, but moisturizing is number one. L’Occitane has this really <a href="https://go.redirectingat.com?id=66960X1516588&amp;xs=1&amp;url=https%3A%2F%2Fwww.loccitane.com%2Fen-us%2Fshea-butter-ultra-rich-comforting-cream-01CV050K18.html%3Ffbclid%3DIwAR1Q9hjxSt0dHD_xhJE8e6nby79wQj0_ueaw_b0jfNSZPIk59iw6awnSBfs&amp;referrer=vox.com&amp;sref=https%3A%2F%2Fwww.vox.com%2Fthe-goods%2F21742395%2Fwinter-survival-scandinavia-norway-pandemic-seasonal-affective-disorder-darkness" rel="sponsored nofollow noopener" target="_blank">awesome face cream </a>that I would recommend to anyone who has to live through the cold months because it really helps keep your face moisturized throughout the day.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4RScWQ">
+<strong>Is anything else, winter tip wise, that you want to add that our readers should know about how you get through the winter, whether it’s physically or emotionally, and how a Scandinavian view informs it?</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0u6VMe">
+People will react to dark and colder months in different ways, and I think just embracing whatever you’re feeling [is important.] Telling yourself that it’s okay if you’re more tired, it’s okay if you don’t want to go outside, and it’s okay if you feel less energized and don’t want to socialize much, or anything that you’re feeling. Just embrace what you’re going through, because it is hard when it’s so dark all the time, and maybe your sleeping rhythm is a bit off and your eating rhythm is a bit off. Be a bit more aware of self-care.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3Y83iP">
+Of course, right now it’s hard to not isolate. So keep in touch with your friends, and if you have a partner, talk to your partner about how you’re doing. Just embrace the time that you’re in.
+</p>
+<aside id="qq2rKx">
+<div>
+
+</div>
+</aside></li>
+<li><strong>How to keep your houseplants (and yourself) less miserable this winter</strong> -
+<figure>
+<img alt="a illustration of many leaves and greens with a tiny pair of eyes in the darkness" src="https://cdn.vox-cdn.com/thumbor/jsm7p2bAP936TJ3pnny_UIvYs7g=/470x0:4317x2885/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68470138/_PLANTS.0.jpg"/>
+<figcaption>
+If your home is green inside, the outside might not feel so bad. But how do you keep plants alive in winter? | Sarah Lawrence for Vox
+</figcaption>
+</figure>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+A very basic guide to indoor winter gardening, according to experts.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oECXQA">
+<em>Winter will suck. We gathered some of Vox’s coziest minds to help you </em><a href="https://www.vox.com/the-goods/22154095/winter-tips-hacks-less-miserable"><em>make it suck less</em></a><em>.</em>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UB9ooJ">
+So you’ve acquired a houseplant during the Covid-19 pandemic. Or several. Or <a href="https://nypost.com/2020/04/15/people-are-mass-purchasing-plants-during-quarantine/">dozens</a>.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A7Flku">
+You’re certainly not alone. Next to cultivating sourdough, gardening has become one of the most <a href="https://wtop.com/lifestyle/2020/08/another-quarantine-must-have-houseplants-says-the-sill-ceo/">popular Covid-19 pandemic hobbies</a> across the United States as people spend more time at home, <a href="https://www.latimes.com/lifestyle/story/2020-05-30/why-plant-sales-are-soaring-even-at-nurseries-closed-due-to-coronavirus">overwhelming plant nurseries</a> that are still trying to maintain social distancing precautions.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LLPtC6">
+“I can tell you that we have seen worldwide interest in gardening that has approximately doubled in terms of individual participation from 2019 to 2020,” said Dave Whitinger, executive director of the National Gardening Association, in an email. “The number of website visitors to <a href="http://garden.org/">garden.org</a> is twice as high as last year, and most of the gardening companies we have spoken with have reported approximately the same thing. The gardening companies I have spoken to have all told me they have completely sold out their inventory this year.”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mtH73g">
+With so many restrictions on going outside, it seems natural to want to bring some of the outdoors inside (or at least close by). Plants bring us numerous benefits. Beyond the obvious aesthetics, your pothos plants, African violets, and succulents can<a href="https://journals.ashs.org/horttech/view/journals/horttech/30/1/article-p55.xml"> relieve stress</a> and<a href="https://www.sciencedaily.com/releases/2014/09/140901090735.htm"> boost productivity</a>. (Their air-cleaning benefits, however, are a<a href="https://www.theatlantic.com/science/archive/2019/03/indoor-plants-clean-air-best-none-them/584509/"> bit more questionable</a>.)
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pXzFWi">
+But now as we head into the winter, when cooler outdoor air becomes less hospitable to fingers and fronds alike, first-time gardeners are facing the challenge of nurturing their new charges through one of the toughest times of year.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GrDaWP">
+To find out more, I called up experts at the<a href="https://www.usbg.gov/"> United States Botanic Garden</a> in Washington, DC. It’s the oldest continuously operating botanic garden in the US and turns 200 this year. It contains nearly 29,000 square feet of indoor growing space, in addition to five acres of outdoor gardens. Its<a href="https://www.usbg.gov/plant-collections"> 65,000-plant collection</a> includes<a href="https://www.usbg.gov/plants/chocolate-plant"> chocolate plants</a>, orchids, the endangered <a href="https://www.usbg.gov/plants/ma%CA%BBo-hau-hele-or-aloalo">aloalo</a> flower, and the crown jewels, two<a href="https://www.usbg.gov/corpse-flowers-us-botanic-garden"> 8-foot-tall flowers</a> that look like deformed penises and smell like rotting corpses. I figured they would know a thing or two about keeping fussy plants alive.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lvS4Kz">
+Whether your thumbs are barely turning green or you’re an aspiring<a href="https://www.vox.com/the-highlight/2019/12/30/21031913/how-to-keep-houseplants-alive-masterclass-plants-swiss-cheese-millennials-plantfluencer"> plantfluencer</a>, here’s what to know about keeping your plants (and maybe yourself) happy and healthy through the cold months.
+</p>
+<h3 id="Am2iQ7">
+Plants can prepare for winter, but they may need your help
+</h3>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6HRtQE">
+The first step in getting your household foliage to survive the winter is to do some homework. That can involve doing some research in a<a href="https://garden.org/plants/view/78237/Moth-Orchid-Phalaenopsis/"> plant database</a> to learn more about the ideal conditions for your plant, like temperatures, sunlight, and soil. You can also look up the<a href="https://planthardiness.ars.usda.gov/PHZMWeb/"> US Department of Agriculture hardiness zone</a> you live in, which can help determine which of your plants can survive the winter outdoors and which need the warmth of your home.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m6NW8y">
+“Getting a little bit of background of the plants is probably one of the most critical things for winter care,” said Angela Weber-Hetrick, the gardens and grounds supervisor at the US Botanic Garden. “Tropical needs are a lot different than your hardy plants, or Zone 7a, which is what we are here in the DC area.”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yLjjgx">
+Plants themselves are quite varied, so it’s difficult to come up with broad recommendations for every bit of greenery. Weber-Hetrick explained that there are plants that do winter prep of their own. Many plants, but particularly perennials that experience winters in the wild, can go dormant when the season changes. That’s when the plant stops growing actively. Its leaves and stems may even fall off, but the root structure is still alive. (A general way to test whether a <a href="https://planethouseplant.com/how-to-tell-if-a-plant-is-dead/">plant is alive </a>is to bend the stem. If it’s pliable, it’s alive, but if it’s brittle, it’s probably dead.)
+</p>
+<figure class="e-image">
+<img alt="The World Deserts exhibit at the US Botanic Garden in Washington, DC." src="https://cdn.vox-cdn.com/thumbor/uvxCFEn106CfE-5AJAqIwQ6R-iQ=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22144831/World_Deserts_at_U.S._Botanic_Garden.jpg"/> <cite>Devin Dotson/US Botanic Garden</cite>
+<figcaption>
+The World Deserts exhibit, filled with succulents, grasses, shrubs, and other flowering plants, at the US Botanic Garden in Washington, DC.
+</figcaption>
+</figure>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R059mI">
+The signs of dormancy can be subtle in houseplants. It can be as simple as their growth slowing. But not every piece of vegetation hunkers down for the season. <a href="https://succulentsbox.com/blogs/blog/succulent-dormancy-101">Succulents</a> like aloe go dormant in the summer while other succulents like agave go dormant in the winter, for example.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="35exsZ">
+When it comes to plants that go dormant in the winter, it’s all the more critical for them to be at their healthiest as the days get shorter.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gr9Hcz">
+“In fall, they’re starting to store up all their carbohydrates, and really what they are trying to do is basically store as much energy as they can to make it through the winter,” Weber-Hetrick said.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9h1Uhk">
+Tropical plants, like philodendron, cane, and bamboo, also respond to shorter days with less growth, thereby consuming less water and fertilizer. And other species may need some trimming to get rid of dead branches or decaying leaves. “Sometimes it needs a good pruning, a good haircut, before going into the winter months,” Weber-Hetrick said.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Rm3YUh">
+But regardless of the species, once winter begins, you, the plant owner, become the gatekeeper for almost everything that a plant needs to survive if it’s kept indoors. So it’s on you to figure out what your garden needs.
+</p>
+<h3 id="7VpaTk">
+Keep a close eye on your greenery and establish a routine
+</h3>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZNIeBu">
+Every home has its own <a href="https://www.nytimes.com/2013/09/01/sunday-review/vive-le-terroir.html">terroir</a>, and general plant care guidelines may be too vague for your porch, windowsill, or hanging basket. That’s why your own observations are crucial.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YNPITK">
+“You can kind of ‘listen to your plants’ in terms of just kind of looking at them,” said Chelsea McKinley, a plant health specialist at the US Botanic Garden. “If it seems like they’re drying out more frequently and they’re putting out more growth, then that’s a sign that they’re ready for more water and maybe for some light fertilizing.”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="i3ogE4">
+Throughout the winter, here are some of the key things to observe on roots, stems, leaves, and buds to help your plants thrive.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9Z9kcY">
+<strong>Pests:</strong> Make sure there aren’t any stowaways on plants you bring inside, and keep an eye out for any critters that could harm them, like aphids and mealybugs. Check the undersides of leaves for even tinier pests like spider mites. “They usually cause a silvering or yellowing of the leaves,” McKinley said. “Those you might need a magnifying glass to see.”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JpBmGL">
+If you are repotting or moving plants to a different container, make sure the new vessel is sterile. Use a mild bleach solution and rinse thoroughly to prevent bacterial or fungal infections.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B7mVVY">
+<strong>Light:</strong> Plants depend on photosynthesis, the process by which they use light, carbon dioxide, and water to make sugar and oxygen. With the sun going down earlier, every photon is precious. Some plants can cope with less light, but others may need the assistance of a growing lamp. Check to make sure what kind of lighting your plant needs and ensure your lighting source is adequate, especially if it’s a supplemental source. “You just want to make sure that lightbulb is fairly bright and has both red and blue wavelengths in the spectrum,” McKinley said. If you are just relying on sunlight, the optimal position can change through the winter, so be prepared to move your plants.
+</p>
+<figure class="e-image">
+<img alt="The Tropics exhibit at the US Botanic Garden in Washington, DC." src="https://cdn.vox-cdn.com/thumbor/1Q__UZREG--veLTgPaQd3VsBp9s=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22144845/Tropics_house_at_U.S._Botanic_Garden__1_.jpg"/> <cite>Devin Dotson/US Botanic Garden</cite>
+<figcaption>
+Light shines through the Tropics exhibit at the US Botanic Garden in Washington, DC.
+</figcaption>
+</figure>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KEjzL3">
+<strong>Temperature:</strong> As it gets cold outside, it becomes more important to maintain warmth inside. Though some plants like <a href="https://www.usbg.gov/orchids-focus-exhibit">orchids</a> prefer a bit of a nighttime drop in temperature, most prefer steady conditions, so avoid placing them in drafty areas.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="J84bTU">
+<strong>Water:</strong> Both too much and too little water can be harmful. That can manifest as wilting or yellowing leaves. But rather than waiting for a plant to show signs of distress, one sign that a plant may be ready to water is if the top centimeter or two of soil is dry.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HPyqKl">
+“When you do water, make sure the entire root bulb gets really wet,” McKinley said. “You want about 10 percent of the water you put into the pot to come out the bottom of the pot.” This helps flush out salt in the root structure. But make sure the water drains away and that the plant doesn’t remain sitting in water.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5bXnbl">
+Some chemicals in tap water can also be harmful to plants, leading to problems like yellowing leaves. You can use distilled water or leave some water out for 24 hours to allow residual chlorine to evaporate out.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xTuGxk">
+<strong>Humidity:</strong> Running the furnace in the winter can dry out the air in your home. And as dry, heated air parches your throat, it can desiccate plants as well. A humidifier can help reduce these effects. So can misting plants with a spray bottle. Maintaining proper humidity can also reduce the need for watering. But make sure to wipe down leaves after misting since tap water can leave behind mineral deposits as it evaporates. A wipe will also remove household dust that can block sunlight.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZmKtOD">
+Balancing all of these elements may be tricky at first, but over time, it should get easier to establish a plant care rhythm and routine. “Plants love consistency,” Weber-Hetrick said.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0HEHVw">
+If you’re looking for inspiration, you can also explore the<a href="https://www.usbg.gov/take-virtual-tour"> US Botanic Garden virtually</a>. And while we’re all housebound this winter with our aloes, begonias, and cacti, know that it’s totally okay to <a href="https://news.psu.edu/story/141343/2008/08/25/research/probing-question-does-talking-plants-help-them-grow">talk to your plants</a>; just be cautious if they start talking back.
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TOU5BA">
+</p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
+<ul>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Olympics | Surfing and breakdancing among four sports to win Paris 2024 spot</strong> - Skateboarding and sports climbing are the other two events</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Champions League | Defeats hurt, but my way is to always fight, says Buffon</strong> - The Juventus icon talks about dealing with failure and what keeps him going.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aus vs Ind | Green in good touch</strong> - Umesh and Ashwin put up a fine show.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Formula One | Mercedes fined for pitstop bungle</strong> - Mercedes mistakenly put tyres reserved for teammate Valtteri Bottas onto Russell’s car after both pitted when the safety car was deployed.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aus vs Ind | Jadeja may miss first Test</strong> - Concussion rule mandates 7-10 days’ rest.</p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
+<ul>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Battered fields, shattered dreams</strong> - Coastal and Rayalaseema districts in the State bore the brunt of Cyclone Nivar that inflicted extensive crop loss; enumeration is under way for quick disbursal of aid to affected farmers</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Three months of toil swept away by a flood</strong> - 19,000 tonnes of tomato crop suffers damage in Chittoor district</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Modi backs Macron in fight against terror</strong> - PM calls up French leader amid spate of knife attacks</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hopes on liberal government aid</strong> - Cyclone flattens crops in over 1.27 lakh hectares in Nellore and Prakasam districts</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NCP, BJP trade charges over Sharad Pawar’s stand on farm laws</strong> - Letters reportedly written by NCP chief when he was Union agriculture minister are in circulation</p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
+<ul>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: Trade talks ‘have reached critical stage’</strong> - The UK says it is still working for a deal, but the EU’s mood is described as “gloomy”.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: All you need to know about the UK leaving the EU</strong> - Time is running out for the UK and EU to strike a deal - what is happening now?</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ikea scraps traditional catalogue after 70 years</strong> - The end of the catalogue is “emotional but rational” as fewer people are reading it, the company says.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus France: Elderly woman fined for lockdown form error</strong> - A woman aged 73 with dementia is fined for having the wrong date on her lockdown exemption form.</p></li>
+<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Brexit: Will the borders be ready?</strong> - With one month to go until the end of transition, we look at the challenges to come on the UK’s borders.</p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
+<ul>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New report reveals Apple’s roadmap for when each Mac will move to Apple Silicon</strong> - High-end Macs could have as many as 32 performance cores to the M1’s four. - <a href="https://arstechnica.com/?p=1728122">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cyberpunk 2077 is equal parts beautiful and messy</strong> - 20 hours in, Night City is a majestic masterpiece with a lot of rough edges. - <a href="https://arstechnica.com/?p=1727962">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rudy Giuliani hospitalized with COVID-19 in latest Trump-sphere infection</strong> - At least 40 others in Trump’s inner circle have been infected since September. - <a href="https://arstechnica.com/?p=1728110">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Despite the pandemic, SpaceX is crushing its annual launch record</strong> - The Block 5 variant has been a true workhorse. - <a href="https://arstechnica.com/?p=1727956">link</a></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>This Arizona college student has taken over 60 driverless Waymo rides</strong> - Human drivers are pretty safe, making it hard to prove driverless tech is safer. - <a href="https://arstechnica.com/?p=1725934">link</a></p></li>
+</ul>
+<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
+<ul>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How does a redditor get karma when they don’t deserve it?</strong> - <!-- SC_OFF --></p>
+<div class="md">
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Piece of cake
+</p>
+</div>
+<!-- SC_ON -->
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/Cherbotsky"> /u/Cherbotsky </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/k8c3n1/how_does_a_redditor_get_karma_when_they_dont/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/k8c3n1/how_does_a_redditor_get_karma_when_they_dont/">[comments]</a></span></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Thats a Bug</strong> - <!-- SC_OFF --></p>
+<div class="md">
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+<strong>Scientist: Dick Bug</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Other Scientist: no
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+<strong>Scientist: Penis Beetle</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Other Scientist: no
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+<strong>Scientist: Cock Roach</strong>
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+Other Scientist: fine whatever
+</p>
+</div>
+<!-- SC_ON -->
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/nyperfox"> /u/nyperfox </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/k8it2s/thats_a_bug/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/k8it2s/thats_a_bug/">[comments]</a></span></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An Arab family residing in Europe was considering putting their grandfather (Abdullah) in a nursing home. All the Arab Facilities were completely full, so they had to put him in an Italian one. After a few weeks there, they came to visit their Grandfather.</strong> - <!-- SC_OFF --></p>
+<div class="md">
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+“How do you like it here?” asked the grandson. “It’s wonderful! Everyone here is so courteous and respectful,” answered grandpa. “We’re so happy for you,” said the Grandson. “We were worried that this was the wrong place for you, since you’re a little different from everyone.”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+“Oh, no! Let me tell you about how wonderfully they treat the residents here,” Abdullah said, with a big smile on his face. “There’s a musician here–he’s 85 years old. He hasn’t played the violin in 20 years, and everyone still calls him Maestro! There is a judge in here–he’s 90 years old. He hasn’t been on the bench in 25 years, and everyone still calls him Your Honor! There’s a dentist here too–95 years old. He hasn’t fixed a tooth for 30 years, and everyone still calls him Doctor!”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+“And Me–I haven’t had sex for 35 years, and they still call me The Fucking Arab.”
+</p>
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+[apologies for the racism; if it’s any consolation, am partly arab, so, yeah–just trying to laugh at myself whenever I can… cheers.]
+</p>
+</div>
+<!-- SC_ON -->
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/throughmethroughyou"> /u/throughmethroughyou </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/k81pk5/an_arab_family_residing_in_europe_was_considering/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/k81pk5/an_arab_family_residing_in_europe_was_considering/">[comments]</a></span></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The first time I had sex, it was in my parent’s bedroom. My girlfriend giggled nervously and moaned, “This is a bit awkward.” I grunted…</strong> - <!-- SC_OFF --></p>
+<div class="md">
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+“Just ignore them!”
+</p>
+</div>
+<!-- SC_ON -->
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/honolulu_oahu_mod"> /u/honolulu_oahu_mod </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/k8emhf/the_first_time_i_had_sex_it_was_in_my_parents/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/k8emhf/the_first_time_i_had_sex_it_was_in_my_parents/">[comments]</a></span></p></li>
+<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The cheating wife</strong> - <!-- SC_OFF --></p>
+<div class="md">
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
+A guy thought his wife was cheating on him.So he waited for her to leave that night and jumped in a cab to follow her. By following her he found out she was working in a whorehouse. The guy says to the cabbie, “Wanna make a $ 100?” The cabbie says, “Sure, what do I have to do?”. The guy replied that all the cabbie has to do was go inside the whorehouse and grab his wife and put her in the back of the cab and take them home. So the cabbie goes in. A couple of minutes later the whore house gets kicked open, and the cabbie is dragging this woman out who is kicking, biting, punching, and fighting all the way to the cab. The cabbie opens the door to the cab, throws the girl inside, and tells the man, “Here, hold her!!” The man looks down at the girl and says to the cabbie, “THIS AIN’T MY WIFE”. The cabbie replied, “I KNOW, IT’S MINE; I’M GOING BACK IN FOR YOURS!!”.
+</p>
+</div>
+<!-- SC_ON -->
+<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/sidtheslothy23"> /u/sidtheslothy23 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/k8j7zl/the_cheating_wife/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/k8j7zl/the_cheating_wife/">[comments]</a></span></p></li>
+</ul>
+
+
+<script>AOS.init();</script></body></html>
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@@ -13,9 +13,9 @@ Archive | Daily Reports
 <li> <a href="#covid-19">Covid-19</a>
 </li></li></ul>
 <h2 id="daily-dose">Daily Dose</h2>
-<ul id="daily-dose-list"><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
+<ul id="daily-dose-list"><li><a href="./archive-daily-dose/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
 </ul>
 <h2 id="covid-19">Covid-19</h2>
-<ul id="covid-19-list"><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
+<ul id="covid-19-list"><li><a href="./archive-covid-19/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
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