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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>A precise score for the regular monitoring of COVID-19 patients condition validated within the first two waves of the pandemic</strong> -
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Purpose. The sudden outbreak of COVID-19 pandemic have shown that medical community needs an accurate and interpretable aggregated score not only for an outcome prediction but also for a daily patient9s condition assessment. Due to a continuously changing pandemic landscape, a robustness becomes a crucial additional requirement for the score. Materials and methods. In this research a real-world data collected within the first two waves of COVID-19 pandemic was used. The first wave data (1349 cases collected from 27.04.2020 to 03.08.2020) was used as a training set for the score development, while the second wave data (1453 cases collected from 01.11.2020 to 19.01.2021) was used as a validating set. For all the available patients features we tested their association with an outcome using a robust linear regression. Statistically significant features were taken to the further analysis for each of which their partial sensitivity, specificity and promptness were estimated. The sensitivity and the specificity were further combined into a feature informativeness index. Results. The developed score was derived as a weighted sum of the following 9 features showed the best trade-off between informativeness and promptness: APTT (&gt; 42 sec, 4 points), CRP (&gt; 146 mg/L, 3 points), D-dimer (&gt; 2149 mkg/L, 4 points), Glucose (&gt; 9 mmol/L, 4 points), Hemoglobin (&lt; 115 g/L, 3 points), Lymphocytes (&lt; 0,7<em>10^9/L, 3 points), Total protein (&lt; 61 g/L, 6 points), Urea (&gt; 11 mmol/L, 5 points) and WBC (&gt; 13,5</em>10^9/L, 4 points). Thus, the proposed score ranges between 0 and 36 points. Internal and temporal validation showed that sensitivity and specificity over 90% may be achieved with an expected prediction range &gt;7 days. Moreover, we demonstrated a high robustness of the score to the varying peculiarities of the pandemic. For the additional simplicity of application we split the full range of the score into four parts associated with particular death/discharge odds (3:1, 1:1, 1:4) determined with bounds 22, 14 and 5 points correspondingly. Conclusions. An extensive application of the score within the second wave of COVID-19 pandemic showed its potential for the optimization of patients management as well as improvement of medical staff attentiveness during a high workload stress. The transparent structure of the score as well as tractable cut-off bounds simplified its implementation into a clinical practice.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.09.21249859v2" target="_blank">A precise score for the regular monitoring of COVID-19 patients condition validated within the first two waves of the pandemic</a>
</div></li>
<li><strong>Predictors of Social Distancing and Hand Washing among Adults in Five Countries during COVID-19</strong> -
<div>
Proper hand washing and social distancing measures have been promoted as mitigating strategies to slow the spread of COVID-19 across the world. However, no study to date has investigated the risk and protective characteristics associated with practicing proper hand washing or social distancing. The present study examined the effects of such characteristics among 2,509 adults from the United States, Italy, Spain, the Kingdom of Saudi Arabia, and India. In the overall sample, age was significantly associated with social distancing (b = 0.07, β = 0.36, p = .001) but not hand washing. Lesbian women and gay men were less likely to engage in social distancing (b = -0.92, β = -0.07, p = .001) and hand washing (b = -0.39, β = -0.08, p &lt; .001) relative to their heterosexual peers. No significant differences were found in the overall sample with regard to education level or employment status, but rural (b = -0.45, β = -0.07, p = .003) respondents were significantly less likely to practice social distancing compared to their urban counterparts. Furthermore, both suburban (b = -0.12, β = -0.06, p = .014) and rural (b = -0.13, β = -0.05, p = .022) respondents were significantly less likely to practice appropriate hand washing compared to their urban peers. Taken together, the results suggest multiple nuanced disparities exist regarding social distancing and hand washing among adults internationally. As such, more tailored and culturally-responsive clinical and community-based interventions may be needed to promote preventive measures to mitigate existing COVID-related disparities.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/zy82h/" target="_blank">Predictors of Social Distancing and Hand Washing among Adults in Five Countries during COVID-19</a>
</div></li>
<li><strong>Mixed Emotions, But Not Positive or Negative Emotions, Facilitate Legitimate Virus-Prevention Behaviors and Eudaimonic Outcomes in the Emergence of the COVID-19 Crisis</strong> -
<div>
We report four studies (N=1419) examining emotional reactions from March to April 2020, when COVID-19 exhibited exponentially increasing infections and fatalities. Specifically, we examined associations between emotions with self-reported intentions to enact virus-prevention behaviors that protect oneself from COVID-19 and eudaimonic functioning. Study 1A, 1B, and Study 2 provided naturalistic evidence that mixed emotions predicted legitimate virus-prevention behaviors and eudaimonic functioning in the United States and Singapore, and Study 2 also supported receptivity as a mediator. Finally, Study 3 provided experimental evidence that mixed emotions causally increased legitimate virus-prevention behaviors relative to neutral, positive emotion, and negative emotion conditions, whereas eudaimonic functioning was increased only relative to the neutral condition. Across all studies, positive and negative emotions were unrelated to legitimate virus-prevention behaviors, while relationships with eudaimonic functioning were inconsistent. While self-reported measures do not represent actual behaviors, the findings suggest a potential role for mixed emotions in pandemic-related outcomes.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/ftxb7/" target="_blank">Mixed Emotions, But Not Positive or Negative Emotions, Facilitate Legitimate Virus-Prevention Behaviors and Eudaimonic Outcomes in the Emergence of the COVID-19 Crisis</a>
</div></li>
<li><strong>Racial and ethnic differences in COVID-19 vaccine hesitancy and uptake</strong> -
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Background: Racial and ethnic minorities have been disproportionately impacted by COVID-19. In the initial phase of population-based vaccination in the United States (U.S.) and United Kingdom (U.K.), vaccine hesitancy and limited access may result in disparities in uptake. Methods: We performed a cohort study among U.S. and U.K. participants in the smartphone-based COVID Symptom Study (March 24, 2020-February 16, 2021). We used logistic regression to estimate odds ratios (ORs) of COVID-19 vaccine hesitancy (unsure/not willing) and receipt. Results: In the U.S. (n=87,388), compared to White non-Hispanic participants, the multivariable ORs of vaccine hesitancy were 3.15 (95% CI: 2.86 to 3.47) for Black participants, 1.42 (1.28 to 1.58) for Hispanic participants, 1.34 (1.18 to 1.52) for Asian participants, and 2.02 (1.70 to 2.39) for participants reporting more than one race/other. In the U.K. (n=1,254,294), racial and ethnic minorities had similarly elevated hesitancy: compared to White participants, their corresponding ORs were 2.84 (95% CI: 2.69 to 2.99) for Black participants, 1.66 (1.57 to 1.76) for South Asian participants, 1.84 (1.70 to 1.98) for Middle East/East Asian participants, and 1.48 (1.39 to 1.57) for participants reporting more than one race/other. Among U.S. participants, the OR of vaccine receipt was 0.71 (0.64 to 0.79) for Black participants, a disparity that persisted among individuals who specifically endorsed a willingness to obtain a vaccine. In contrast, disparities in uptake were not observed in the U.K. Conclusions: COVID-19 vaccine hesitancy was greater among racial and ethnic minorities, and Black participants living in the U.S. were less likely to receive a vaccine than White participants. Lower uptake among Black participants in the U.S. during the initial vaccine rollout is attributable to both hesitancy and disparities in access.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.25.21252402v1" target="_blank">Racial and ethnic differences in COVID-19 vaccine hesitancy and uptake</a>
</div></li>
<li><strong>Histopathological assessments reveal retinal vascular changes, inflammation, and gliosis in patients with lethal COVID-19</strong> -
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Importance: We are in the midst of the human coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), which is of historic proportions, the likes of which we have not seen in 102 years. Despite being primarily a respiratory virus, COVID-19 can also present with non-respiratory signs, including ocular symptoms as conjunctival hyperemia, chemosis, epiphora, increased secretions, ocular pain, photophobia and dry eye. The virus has also been detected within the anterior chamber and in the ocular fluids suggesting that ocular tissue maybe affected due to Sars-CoV-2 infection. Objective: To assess for histopathological changes within the retina and the choroid and determine the long-term sequelae of the viral infection. Design, Setting, and Participants: 12 donor eyes from COVID-19 positive individuals and similar age matched donor eyes from patients with negative test for SARS-CoV-2 were assessed. Eyes were fixed in 4% paraformaldehyde and 0.5% glutaraldehyde in PBS within 6 hours postmortem. Main Outcomes and Measures: Globes were evaluated with macroscopic, SLO and OCT imaging. Macula and peripheral regions were processed for epon-embedding and immunocytochemistry with markers for SARS-CoV-2 infection, gliosis, inflammation and vasculature. Results: Fundus analysis shows hemorrhagic spots and increased vitreous debris in several of the COVID-19 eyes compared to the control. OCT based measurements indicated an increased trend in retinal thickness in the COVID-19 eyes, however the difference was not statistically significant. Histology of the retina showed presence of hemorrhages and central cystoid degeneration in several of the donors. Whole mount analysis of the retina labeled with markers showed changes in retinal microvasculature, increased inflammation, and gliosis in the COVID-19 eyes compared to the controls. The choroidal vasculature displayed localized changes in density and signs of increased inflammation in the COVID-19 samples. Conclusions and Relevance: In situ analysis of the retinal tissue suggested that there are severe subclinical abnormalities that could be detected in the COVID-19 eyes. This study provides a rationale for evaluating the ocular physiology of patients that have recovered from COVID-19 infections to further understand the long-term effects caused by this virus.
</p>
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.25.21251531v1" target="_blank">Histopathological assessments reveal retinal vascular changes, inflammation, and gliosis in patients with lethal COVID-19</a>
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<li><strong>Interpreting vaccine efficacy trial results for infection and transmission</strong> -
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Randomized controlled trials (RCTs) have shown high efficacy of multiple vaccines against SARS-CoV-2 disease (COVID-19), but evidence remains scarce about vaccines9 efficacy against infection with, and ability to transmit, the virus. We describe an approach to estimate these vaccines9 effects on viral positivity, a prevalence measure which under reasonable assumptions forms a lower bound on efficacy against transmission. Specifically, we recommend separate analysis of positive tests triggered by symptoms (usually the primary outcome) and cross-sectional prevalence of positive tests obtained regardless of symptoms. The odds ratio of carriage for vaccine vs. placebo provides an unbiased estimate of vaccine effectiveness against viral positivity, under certain assumptions, and we show through simulations that likely departures from these assumptions will only modestly bias this estimate. Applying this approach to published data from the RCT of the Moderna vaccine, we estimate that one dose of vaccine reduces the potential for transmission by at least 61%, possibly considerably more. We describe how these approaches can be translated into observational studies of vaccine effectiveness.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.25.21252415v1" target="_blank">Interpreting vaccine efficacy trial results for infection and transmission</a>
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<li><strong>To Sit Quietly in a Room Alone: The Psychology of Social, Material, and Sensation Seeking Input</strong> -
<div>
External input is any kind of physical stimulation created by an individual’s surroundings that can be detected by the senses. The present research established a novel conceptualization of this construct by investigating it from the perspective of three research areas that tap into its different aspects but have so far been disconnected—materialism, social motives, and sensation seeking. Studies 1-5 focused on individual differences regarding external input (i.e., the needs for material, social, and sensation seeking input). It was established that the three needs are positively related and constitute different dimensions of the overarching construct of external input, that the needs for social and sensation seeking input have negative consequences for how people experience long-term input deprivation (i.e., COVID-19 restrictions), and that the need for material input has negative consequences for people’s experiences of short-term input deprivation (i.e., sitting in a chair without doing anything else but thinking). Finally, Study 6 focused on external input as a situational characteristic and showed that the degree of sensation seeking input constituting various situations is a more important predictor, relative to social and material input, of how enjoyable and meaningful people perceive the situations and of their willingness to engage in them. Overall, the present research established a novel construct that has fundamental implications for people’s experiences and actions in a range of different contexts.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/zpf6b/" target="_blank">To Sit Quietly in a Room Alone: The Psychology of Social, Material, and Sensation Seeking Input</a>
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<li><strong>PREDICTORS OF PSYCHOLOGICAL STRESS OCCURRING AFTER THE FIRST WAVE OF THE COVID-19 PANDEMIC IN POLAND</strong> -
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The article presents the results of research aimed to identify the predictors of psychological distress among Poles seven months after the occurrence of the first case of COVID-19. In order to gather the research material, the CAWI on-line survey method was applied and carried out within the framework of the Ariadna Research Panel on the sample of 1079 Poles aged 15 and over. The results of the conducted research indicate that Polish society experienced psychological distress as a result of the first wave of the pandemic. According to the Kessler Psychological Distress Scale (K10), no mental disorders were observed among 36% of Poles, mild mental disorders were observed among 23% of respondents, average levels of disorders were observed among 18% of respondents, whereas high levels of disorders were observed among 23% of respondents. A hierarchical linear regression analysis was used to identify the predictors of psychological distress. In the first stage, socio-demographic variables explained 20% of the distress variance. In the second stage, the variables measuring social nuisances of the pandemic were introduced, which increased the percentage of the explained stress variance to 33%. In the third stage, the introduced psychological variables increased the percentage of the explained variance to 73%. The main factor which increased stress levels was neuroticism. The conducted analyses have shown that the lack of social, economic and psychological capital significantly increases the susceptibility to distress when a threat to life and health lasts for a prolonged period of time.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/2k8px/" target="_blank">PREDICTORS OF PSYCHOLOGICAL STRESS OCCURRING AFTER THE FIRST WAVE OF THE COVID-19 PANDEMIC IN POLAND</a>
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<li><strong>Refuting the myth of a ‘tsunami’ of mental ill-health in populations affected by COVID-19: Evidence that response to the pandemic is heterogenous, not homogeneous</strong> -
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Background: The current study argues that population prevalence estimates for mental health disorders, or changes in mean scores over time, may not adequately reflect the heterogeneity in mental health response to the COVID-19 pandemic within the population. Methods: The COVID-19 Psychological Research Consortium (C19PRC) Study is a longitudinal, nationally representative, online survey of UK adults. The current study analysed data from its first three waves of data collection: Wave 1 (March 2020, N=2025), Wave 2 (April 2020, N=1406) and Wave 3 (July 2020, N=1166). Anxiety-depression was measured using the Patient Health Questionnaire Anxiety and Depression Scale (a composite measure of the PHQ-9 and GAD-7) and COVID-19 related PTSD with the International Trauma Questionnaire. Changes in mental health outcomes were modelled across the three waves. Latent class growth analysis was used to identify subgroups of individuals with different trajectories of change in anxiety-depression and COVID-19 PTSD. Latent class membership was regressed on baseline characteristics. Results: Overall prevalence of anxiety-depression remained stable, while COVID-19 PTSD reduced between Waves 2 and 3. Heterogeneity in mental health response was found, and hypothesised classes reflecting (i) stability, (ii) improvement, and (iii) deterioration in mental health were identified. Psychological factors were most likely to differentiate the improving, deteriorating and high-stable classes from the low-stable mental health trajectories. Conclusions: A low-stable profile characterised by little-to-no psychological distress (‘resilient’ class) was the most common trajectory for both anxiety-depression and COVID-19 PTSD. Monitoring these trajectories is necessary moving forward, in particular for the ~30% of individuals with increasing anxiety-depression levels.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/ujwsm/" target="_blank">Refuting the myth of a ‘tsunami’ of mental ill-health in populations affected by COVID-19: Evidence that response to the pandemic is heterogenous, not homogeneous</a>
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<li><strong>Integrative Therapy based on Yoga, Ayurveda and Modern Western Medicine for Treatment of High-risk Cases of COVID-19: A Telemedicine-Based Case Series</strong> -
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Background: We report a telemedicine-based case-series of thirty high risk COVID-19 positive patients with co-morbidities such as Diabetes Mellitus (DM), Hypertension (HTN), Hypothyroidism, Ulcerative Colitis and Chronic Kidney Disease (CKD) or aged 60 and above (or possibly both), treated successfully using an Integrative Therapy plan based on Ayurveda, Yoga and Modern Western Medicine. The symptoms experienced by the patients included fever, body-ache, sore throat/throat pain, cough/running nose, headache, nasal/chest congestion, stomach problems (such as diarrhea, constipation), nausea, loss of taste, loss of smell, foul smell or taste, loss of appetite, weakness, gastric upset, respiratory trouble (such as breathlessness or high respiration rate) and anxiety. Two patients (both aged above 70) were asymptomatic and remained asymptomatic during the entire course of the treatment. Design: The reported cases have been categorized into YAS (patients taking Yoga and Ayurveda based treatment, with possibly western Supplements), YASP (patients taking Yoga and Ayurveda based treatment, with possibly western Supplements and Paracetamol), YAM (patients taking Yoga and Ayurveda based treatment, and Modern western medicine (MWM) as an adjunct), MYA (patients who first tried the Modern western medicines (in most of the cases mandated by the government) and later switched to Yoga and Ayurveda treatment. The last group has been further subdivided into subgroups – patients who developed new symptoms after the commencement of Yoga and Ayurveda-based treatment (MYA-S) and those who did not (MYS-NS). The YAS group had 4 patients, YASP had 6 patients, YAM had 6 and MYA had 14 patients (MYA-S having 7 and MYA-NS having 7). Case-Series Presentation: Ayurveda is a highly personalized system of medicine that considers the Prakruti (the Ayurvedic constitution) as well as Vikruti (the homeostatic imbalances) in treating the patients. Based on the patient’s symptoms and co-morbidities, a personalized treatment plan including Ayurvedic medicines, Yoga protocol, dietary recommendations and lifestyle modifications was prescribed by a registered Ayurveda doctor and a Yoga consultant. More than half of the symptomatic patients started experiencing improvement within 5 days (90% within 9 days) from the start of the treatment. More than 60% of the symptomatic patients reported at least 90% recovery within 10 days (90% within 17 days) from the start of the treatment. Six patients, whose SpO2 level was observed to be at or below 95%, benefited from the practice of Makarasana and Shithilasana. None of the patients progressed to severe stage of illness. Many patients experienced improvement with respect to their comorbidities besides COVID-related symptoms. Some of them, after recovering from COVID, even sought consultation for long-term management of their comorbidities through Ayurveda and Yoga. Some patients got so convinced about the possibility of restoration of health through Yoga, that they adopted this practice into their lifestyle. Conclusions: The Integrative Therapy was found to be very effective in mitigating the symptoms of all the high-risk cases of COVID-19 patients with comorbidities who remained compliant to the treatment. Considering that approximately 32.8% of the patients with the comorbidities such as DM, HTN, COPD, cardiovascular disease, cerebrovascular disease, chronic kidney disease, Hepatitis B, malignancy, immunodeficiency progress to severe stage of illness, and assuming under the null hypothesis that a similar percentage of patients are expected to progress to a severe stage for the treatment population, the corresponding p-value (incorporating 23 symptomatic patients with one or more of the above comorbidities) turns out to be 1.07 e-4. Integrative Therapy based on classical texts of Ayurveda and Yoga from the East and emergency treatment of modern western medicine may offer a promising and scalable treatment option for COVID-19 patients. More studies including a suitably designed randomized controlled trial is needed to assess its efficacy.
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/58btr/" target="_blank">Integrative Therapy based on Yoga, Ayurveda and Modern Western Medicine for Treatment of High-risk Cases of COVID-19: A Telemedicine-Based Case Series</a>
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<li><strong>Minimizing loss of life in Covid-19 in a 100 day period in the U.S.A. by personalized-dose vaccination and distribution of a limited vaccine supply</strong> -
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Background: We aimed at minimizing loss of lives in the Covid-19 pandemic in the USA by identifying optimal vaccination strategies during a 100-day period with limited vaccine supplies. While lethality is highest in the elderly, transmission and case numbers are highest in the younger. A strategy of first vaccinating the elderly is widely used, thought to protect the vulnerable, elderly best. Despite lower immunogenicity in the elderly, mRNA vaccines retain high efficacy, implying that in the younger, reduced vaccine doses might suffice, thereby increasing vaccination counts with a given vaccine supply. Methods: Using published immunogenicity data of the Moderna mRNA-1273 vaccine, we examined the value of personalized-dose vaccination strategies, using a modeling approach incorporating age-related vaccine immunogenicity, social contact patterns, population structure, Covid-19 case and death rates in the USA in late January 2021. An increase if the number of persons that can be vaccinated and a potential reduction of the individual protective efficacy was accounted for. Results: Age-personalized dosing strategies reduced cases faster, shortening the pandemic, reducing the delay to reaching &lt;1009000 cases/day from 64 to 30 days and avoiding 259000 deaths within 100 days in the USA. In an 9elderly first9 vaccination strategy, mortality is higher even in the elderly. Findings were robust with transmission blocking efficacies of reduced dose vaccination between 30% to 90%, and with a vaccine supply from 1 to 3 million full dose vaccinations per day. Conclusion: Rapid reduction of Covid-19 case and death rate in the USA in 100 days with a limited vaccine supply is best achieved when personalized, age-tailored dosing for highly effective vaccines is used, according to this vaccination strategy model parameterized to U.S. demographics, Covid-19 transmission and vaccine characteristics. Protecting the vulnerable is most effectively achieved by personalized-dose vaccination of all population segments, while an 9elderly first9 approach costs more lives, even in the elderly.
</p>
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.30.21250834v6" target="_blank">Minimizing loss of life in Covid-19 in a 100 day period in the U.S.A. by personalized-dose vaccination and distribution of a limited vaccine supply</a>
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<li><strong>Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide</strong> -
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Neutrophil-mediated activation and injury of the endothelium play a role in the pathogenesis of diverse disease states ranging from autoimmunity to cancer to COVID-19. Neutralization of cationic proteins (such as neutrophil extracellular trap/NET-derived histones) with polyanionic compounds has been suggested as a potential strategy for protecting the endothelium from such insults. Here, we report that the FDA-approved polyanionic agent defibrotide (a pleotropic mixture of oligonucleotides) directly engages histones and thereby blocks their pathological effects on endothelium. In vitro, defibrotide counteracted endothelial cell activation and cell death, whether triggered by purified NETs, COVID-19 serum containing high levels of NETs, or recombinant histone H4. In vivo, defibrotide stabilized the endothelium and protected against histone-accelerated inferior vena cava thrombosis in mice. Mechanistically, defibrotide demonstrated direct and tight binding to histone H4 as detected by both electrophoretic mobility shift assay and surface plasmon resonance. Taken together, these data provide insights into the potential role of polyanionic compounds in protecting the endothelium from thromboinflammation with potential implications for myriad NET- and histone-accelerated disease states.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.21.21252160v2" target="_blank">Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide</a>
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<li><strong>A catalog of associations between rare coding variants and COVID-19 outcomes</strong> -
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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19), a respiratory illness that can result in hospitalization or death. We investigated associations between rare genetic variants and seven COVID-19 outcomes in 543,213 individuals, including 8,248 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome-wide or when specifically focusing on (i) 14 interferon pathway genes in which rare deleterious variants have been reported in severe COVID-19 patients; (ii) 167 genes located in COVID-19 GWAS risk loci; or (iii) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, with results publicly browsable at https://rgc-covid19.regeneron.com.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.10.28.20221804v2" target="_blank">A catalog of associations between rare coding variants and COVID-19 outcomes</a>
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<li><strong>Initial evaluation of a mobile SARS-CoV-2 RT-LAMP testing strategy</strong> -
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) control in the United States remains hampered, in part, by testing limitations. We evaluated a simple, outdoor, mobile, colorimetric reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay workflow where self-collected saliva is tested for SARS-CoV-2 RNA. From July 16 to November 19, 2020, 4,704 surveillance samples were collected from volunteers and tested for SARS-CoV-2 at 5 sites. A total of 21 samples tested positive for SARS-CoV-2 by RT-LAMP; 12 were confirmed positive by subsequent quantitative reverse-transcription polymerase chain reaction (qRT-PCR) testing, while 8 were negative for SARS-CoV-2 RNA, and 1 could not be confirmed because the donor did not consent to further molecular testing. We estimated the RT-LAMP assay9s false-negative rate from July 16 to September 17, 2020 by pooling residual heat-inactivated saliva that was unambiguously negative by RT-LAMP into groups of 6 or less and testing for SARS-CoV-2 RNA by qRT-PCR. We observed a 98.8% concordance between the RT-LAMP and qRT-PCR assays, with only 5 of 421 RT-LAMP negative pools (2,493 samples) testing positive in the more sensitive qRT-PCR assay. Overall, we demonstrate a rapid testing method that can be implemented outside the traditional laboratory setting by individuals with basic molecular biology skills and can effectively identify asymptomatic individuals who would not typically meet the criteria for symptom-based testing modalities.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.07.28.20164038v3" target="_blank">Initial evaluation of a mobile SARS-CoV-2 RT-LAMP testing strategy</a>
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<li><strong>Occupational Portrait of A Pandemic Workforce: Latin Americans in the Health and the Sales &amp; Services Sectors of Canada</strong> -
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Reflecting on present COVID-19 pandemic times in Canada and using both visible and ethnic ancestry information from the 2016 census, the author produced an occupational portrait of the Latin American workforce of the Health and Sales &amp; Services sectors of the country. The focus was on full-time, full-year workers, aged 25-64, who received employment income in 2015. The workforce in the Health and Sales &amp; Services sectors totaled 5.5 thousand and 24.3 thousand individuals respectively. The occupational portrait, which was developed based on the Canadian 2016 NOC occupational classification system, revealed an active participation of Latino workers in activities enhancing sanitary protection and the economic survival of the Canadian population. Women, and established and recent immigrants as well as those reporting Central American ethnic origins were found among those who most participated in the economic activities of the sectors. The most typical jobs performed by Latin American workers were as nursing aides in the Health sector and janitorial (males) and light or specialized cleaners (women) in the Sales &amp; Services sector. The nature of these jobs made them a high health-risk group and vulnerable one in pandemic times as they entail working in close proximity to other colleagues and the general public.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/b76sp/" target="_blank">Occupational Portrait of A Pandemic Workforce: Latin Americans in the Health and the Sales &amp; Services Sectors of Canada</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Antithrombotic Rivaroxaban Evaluation</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Rivaroxaban 10 mg<br/><b>Sponsors</b>:   Hospital Alemão Oswaldo Cruz;   Bayer;   Hospital Israelita Albert Einstein;   Hospital do Coracao;   Hospital Sirio-Libanes;   Hospital Moinhos de Vento;   Brazilian Research In Intensive Care Network;   Brazilian Clinical Research Institute<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Safety and Efficacy Study of Human Monoclonal Antibodies, BRII-196 and BRII-198 for the Treatment of Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: BRII-196 and BRII-198;   Drug: Placebo<br/><b>Sponsor</b>:   Brii Biosciences, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protecting Native Families From COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Motivational Interviewing;   Behavioral: COVID-19 Symptom Monitoring System;   Behavioral: Motivational Interviewing and COVID-19 Symptom Monitoring System;   Other: Supportive Services<br/><b>Sponsor</b>:   Johns Hopkins Bloomberg School of Public Health<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Thymic Peptides in the Treatment of Hospitalized COVID-19 Patients in Honduras</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Thymic peptides<br/><b>Sponsors</b>:   Universidad Católica de Honduras;   Pontificia Universidad Catolica de Chile<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Assess the Safety and Immunogenicity of the Coronavac Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Adsorbed COVID-19 (inactivated) Vaccine<br/><b>Sponsors</b>:   D’Or Institute for Research and Education;   Butantan Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate UB-612 COVID-19 Vaccine in Adolescent, Younger and Elderly Adult Volunteers</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: UB-612;   Biological: Placebo<br/><b>Sponsors</b>:   United Biomedical Inc., Asia;   COVAXX<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Trial to Evaluate the Safety and Efficacy of ATR-002 in Adult Hospitalized Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: ATR-002;   Drug: Placebo<br/><b>Sponsor</b>:   Atriva Therapeutics GmbH<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Treatment Cascade Optimization Study</strong> - <b>Condition</b>:   COVID-19 Testing<br/><b>Interventions</b>:   Behavioral: Navigation Services;   Behavioral: Critical Dialogue;   Behavioral: Brief Counseling;   Behavioral: Referral and Digital Brochure<br/><b>Sponsors</b>:   University of Illinois at Urbana-Champaign;   North Jersey Community Research Initiative;   National Institute on Minority Health and Health Disparities (NIMHD);   University of Michigan<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Adoptive SARS-CoV-2 Specific T Cell Transfer in Patients at Risk for Severe COVID-19</strong> - <b>Condition</b>:   Moderate COVID-19-infection<br/><b>Interventions</b>:   Drug: IMP 1,000 plus SoC;   Drug: IMP 5,000 plus SoC;   Drug: IMP RP2D plus SoC;   Drug: SoC<br/><b>Sponsors</b>:   Universitätsklinikum Köln;   ZKS Köln;   MMH Institute for Transfusion Medicine;   Miltenyi Biomedicine GmbH<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Safety and Immunogenicity Study of Inactivated SARS-CoV-2 Vaccine (Vero Cells) in Healthy Population Aged 18 Years and Above(COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: medium dosage inactivated SARS-CoV-2 vaccine;   Biological: high dosage inactivated SARS-CoV-2 vaccine;   Biological: Placebo<br/><b>Sponsors</b>:   Beijing Minhai Biotechnology Co., Ltd;   Shenzhen Kangtai Biological Products Co., LTD;   Jiangsu Province Centers for Disease Control and Prevention<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccine (Vero Cells) in Healthy Population Aged 18 Years and Above(COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: medium dosage inactivated SARS-CoV-2 vaccine;   Biological: high dosage inactivated SARS-CoV-2 vaccine;   Biological: Placebo<br/><b>Sponsors</b>:   Beijing Minhai Biotechnology Co., Ltd;   Shenzhen Kangtai Biological Products Co., LTD;   Jiangsu Province Centers for Disease Control and Prevention<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate a Single Dose of STI-2020 (COVI-AMG™) in Hospitalized Adults With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: COVI-AMG;   Drug: Placebo<br/><b>Sponsor</b>:   Sorrento Therapeutics, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Safety and Efficacy of FB2001 in Healthy Subjects and Patients With COVID-19 Infection</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: FB2001;   Drug: FB2001 Placebo<br/><b>Sponsor</b>:   Frontier Biotechnologies Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Prone Position onV/Q Matching in Non-intubated Patients With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: prone position<br/><b>Sponsor</b>:   Southeast University, China<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anesthetic &amp; Surgical Protocol for Emergency Surgeries During the Era of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Procedure: Emergency surgical procedures<br/><b>Sponsors</b>:   Benha University;   Tanta University<br/><b>Completed</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Management protocol for Fournier’s gangrene in sanitary regime caused by SARS-CoV-2 pandemic: A case report</strong> - CONCLUSION: Early management prevents the resection of the other organs by inhibiting the contiguous spread of infection.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Possible Antiviral Activity of 5-Aminolevulinic Acid in Feline Infectious Peritonitis Virus (Feline Coronavirus) Infection</strong> - Feline infectious peritonitis (FIP) is a life-threatening infectious disease of cats caused by virulent feline coronavirus (FIP virus: FIPV). For the treatment of FIP, several effective antivirals were recently reported, but many of these are not available for practical use. 5-amino levulinic acid (5-ALA) is a low-molecular-weight amino acid synthesized in plant and animal cells. 5-ALA can be synthesized in a large amount, and it is widely applied in the medical and agricultural fields. We…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19</strong> - The rapid advancement of the COVID-19 pandemic has prompted an accelerated pursuit to identify effective therapeutics. Stages of the disease course have been defined by viral burden, lung pathology, and progression through phases of the immune response. Immunological factors including inflammatory cell infiltration and cytokine storm have been associated with severe disease and death. Many immunomodulatory therapies for COVID-19 are currently being investigated, and preliminary results support…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Modalities and Mechanisms of Treatment for Coronavirus Disease 2019</strong> - Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly throughout the world. Although COVID-19 has a relatively low case severity rate compared to SARS and Middle East Respiratory syndrome it is a major public concern because of its rapid spread and devastating impact on the global economy. Scientists and clinicians are urgently trying to identify drugs to combat the virus with hundreds of clinical trials…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of ACE2 Expression by Ascorbic Acid Alone and its Combinations with Other Natural Compounds</strong> - CONCLUSION: Our study provides valuable experimental confirmation of the efficacy of micronutrients in controlling ACE2 expression-the coronavirus cellular “entry” point. It further validates the importance of nutrient interactions in various aspects of cellular metabolism and in considering potential therapeutic applications of nutrient-based approaches. The study shows that ascorbic acid and its combination with some natural compounds could be included in developing preventive and therapeutic…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect</strong> - Human intestinal epithelial cell line-6 (HIEC-6) cells and primary human hepatocytes (PHHs) were treated with 3-amidinophenylalanine-derived inhibitors of trypsin-like serine proteases for 24 hours. It was proven that treatment with MI-1900 and MI-1907 was tolerated up to 50 μM in HIEC-6. These inhibitors did not cause elevations in extracellular H(2)O(2) levels and in the concentrations of interleukin (IL)-6 and IL-8 and did not alter occludin distribution in HIEC-6. It was also found that…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases</strong> - CONCLUSIONS: Our finding provides two novel natural products as promising SARS-CoV-2 antivirals.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mechanisms of COVID-19 Entry into the Cell: Potential Therapeutic Approaches Based on Virus Entry Inhibition in COVID-19 Patients with Underlying Diseases</strong> - The Coronavirus disease 2019 (COVID-19) virus spread from Wuhan, China, in 2019 and is spreading rapidly around the world. COVID-19 victims are almost associated with cardiovascular disease, high blood pressure, diabetes, and other underlying diseases. Concerning the high prevalence of these disorders, widespread mortality threatens global society, and its fatality rate may increase with increasing COVID-19 prevalence in countries with older populations. Therefore, evaluating patients’ clinical…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A new class of alpha-ketoamide derivatives with potent anticancer and anti-SARS-CoV-2 activities</strong> - Inhibitors of the proteasome have been extensively studied for their applications in the treatment of human diseases such as hematologic malignancies, autoimmune disorders, and viral infections. Many of the proteasome inhibitors reported in the literature target the non-primed site of proteasome’s substrate binding pocket. In this study, we designed, synthesized and characterized a series of novel α-keto phenylamide derivatives aimed at both the primed and non-primed sites of the proteasome. In…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and Influenza virus</strong> - The ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health. Vaccines are ideal solutions to prevent infection, but treatments are also needed for those who have contracted the virus to limit negative outcomes, when vaccines are not applicable. Viruses must cross host cell membranes during their lifecycle, creating a dependency on processes involving membrane dynamics. Thus, in this study we examined whether the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Platelet-Activating Immune Complexes Identified in Critically Ill COVID-19 Patients Suspected of Heparin-Induced Thrombocytopenia</strong> - CONCLUSIONS: Our study identifies platelet-activating ICs as a novel mechanism that contributes to critically ill COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19</strong> - Coronaviruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic, present a significant threat to human health by inflicting a wide variety of health complications and even death. While conventional therapeutics often involve administering small molecules to fight viral infections, small non-coding RNA sequences, known as microRNAs (miRNAs/miR-), may present a novel antiviral strategy. We can take advantage of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation</strong> - SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor inducer of type I interferon (IFN). Here, we report that SARS-CoV-2 nsp12, the viral RNA-dependent RNA polymerase (RdRp), suppresses host antiviral responses. SARS-CoV-2 nsp12 attenuated Sendai virus (SeV)- or poly(I:C)-induced IFN-β promoter activation in a dose-dependent manner. It also inhibited IFN promoter activation triggered by…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection</strong> - SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic, in which acute respiratory infections are associated with high socio-economic burden. We applied high-content screening to a well-defined collection of 5632 compounds including 3488 that have undergone previous clinical investigations across 600 indications. The compounds were screened by microscopy for their ability to inhibit SARS-CoV-2 cytopathicity in the human epithelial colorectal adenocarcinoma cell line, Caco-2. The…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2</strong> - In this study, we developed ACE2-specific, peptide-derived ^(68)Ga-labeled radiotracers, motivated by the hypotheses that (1) ACE2 is an important determinant of SARS-CoV-2 susceptibility, and (2) that modulation of ACE2 in COVID-19 drives severe organ injury. Methods: A series of NOTA-conjugated peptides derived from the known ACE2 inhibitor DX600 were synthesized, with variable linker identity. Since DX600 bears two cystine residues, both linear and cyclic peptides were studied. An ACE2…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sars-CoV-2 vaccine antigens</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318283136">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-COV-2 BINDING PROTEINS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318004130">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for detecting SARS-CoV-2 spike protein</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU317343760">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种3-羟基丁酰化修饰蛋白质药物及其制备方法和应用</strong> - 本发明涉及医药技术领域，公开了一种3‑羟基丁酰化修饰蛋白质药物（例如抗体）及其制备方法和应用，特别是一种3‑羟基丁酰化修饰抗体及其制备方法和应用。发明人经过大量实验发现，3‑羟基丁酸及其类似物修饰蛋白质药物（例如抗体）后，可以显著提高蛋白质药物的热稳定性、对蛋白酶水解的抗性，降低蛋白质药物的等电点，并显著延长其在受试者体内的半衰期，进而提高其药效。修饰后所得蛋白质药物在科研和临床方面具有广阔的应用前景和较高的商业价值。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318140486">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>新冠病毒重组融合蛋白、其制备方法和应用</strong> - 本发明提供一种新冠病毒重组融合蛋白、其制备方法和应用。本发明通过对新冠病毒S和N重组融合蛋白的基因序列进行设计，选择最优的片段进行整合，再通过人源HEK293细胞系统重组表达融合蛋白，经过纯化后对融合蛋白的分子量、纯度进行检测，最后利用融合蛋白制成新冠病毒抗体胶体金检测试纸条/试剂盒。与单独使用S蛋白或N蛋白制备的胶体金检测试纸条相比，该重组融合蛋白制备的胶体金检测试纸条具有更高的灵敏度和更低的漏检率。此外，本发明提供的新冠病毒重组融合蛋白可广泛应用于不同平台技术的新冠抗体检测试剂盒开发，如胶体金、荧光免疫层析、化学发光和酶联免疫等。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318140491">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>稳定的冠状病毒重组蛋白二聚体及其表达载体</strong> - 本发明公开了稳定的冠状病毒重组蛋白二聚体及其表达载体，冠状病毒重组蛋白，由冠状病毒S蛋白S‑RBD、冠状病毒N蛋白的CTD区N‑CTD和将二者偶联的连接子构成。本发明一些实例的冠状病毒重组蛋白，可以形成并维持稳定的二聚体结构，避免单体S‑RBD降解，有利于提高冠状病毒重组蛋白的免疫原性，有望用于制备检测试剂原料、疫苗、抗体、预防或治疗性药物。本发明一些实例的冠状病毒重组蛋白二聚体，具有很好的免疫原性。在疫苗开发领域具有广阔的应用前景。本发明一些实例的表达载体，易于表达冠状病毒重组蛋白二聚体且表达量高。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318107321">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SELF-CLEANING AND GERM-KILLING REVOLVING PUBLIC TOILET FOR COVID 19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318003558">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种新冠病毒S1蛋白的灌流生产系统及方法</strong> - 本发明涉及细胞生物学技术领域，提供了一种新冠病毒S1蛋白的灌流生产系统及方法，包括：细胞反应器，用于培养表达S1蛋白的细胞株；灌流系统，包括过滤装置、出液管、回液管和第一循环泵，所述过滤装置的主体内设有孔径为0.1‑0.2μm的中空纤维柱，用于过滤透出液，截留细胞培养液中的S1蛋白；所述出液管的两端分别与所述细胞反应器和所述中空纤维柱的下端相连通；所述回液管的两端分别与所述细胞反应器和所述中空纤维柱的上端相连通；所述第一循环泵设置于所述出液管与所述中空纤维柱相连的管路中。本发明系统投入成本低且S1蛋白产量高。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318107249">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>检测新冠病毒的方法及试剂盒</strong> - 本发明公开了一种检测新冠病毒的方法及试剂盒。其中，该方法包括以下步骤：1）采集样本；2）采用核酸释放剂提取核酸；3）采用LAMP扩增进行检测，其中，核酸释放剂包括：热敏蛋白酶1000U/L~10000U/L、Tris‑HCl 5~50 mmol/L、曲拉通X‑100体积百分比0.05%<sub>0.5%和金属离子螯合剂0.1</sub>0.5mmol/L，其余为无菌水，热敏蛋白酶为≥55℃加热5~10分钟会完全失活的蛋白酶。应用本发明的检测新冠病毒的方法及试剂盒，检测新冠病毒，检测周期短，操作简单方便，检测结果通俗易懂，检测特异性高，检测成本低。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318107166">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种新型冠状病毒拉曼光谱数据中心的构建方法</strong> - 本发明公开了一种新型冠状病毒拉曼光谱数据中心的构建方法，该方法包括以下步骤：S1.构建新冠病毒结构蛋白拉曼光谱数据库；S2.构建新冠病毒核酸拉曼光谱数据库；S3.构建新冠病毒颗粒拉曼光谱数据库；S4.构建新冠病毒临床检测样本拉曼光谱数据库；将各新型冠状病毒拉曼光谱数据库存入新型冠状病毒拉曼光谱检测服务器构成新型冠状病毒拉曼光谱数据中心。本发明有效建立了一套完整的新型冠状病毒拉曼光谱数据库，为新冠病毒拉曼检测技术提供可靠的标准数据支撑，有效提高检测结果的准确性及置信度。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318107132">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Good, the Bad, and the Embarrassing in America’s COVID-19 Response</strong> - Were Americans too unruly, or did elected officials expect too little of them? - <a href="https://www.newyorker.com/news/the-political-scene/the-good-the-bad-and-the-embarrassing-in-americas-covid-19-response">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Won’t Amnesty International Call Alexey Navalny a Prisoner of Conscience?</strong> - The Russian regime has used both its vast media infrastructure and its judicial system to vilify its opponents. - <a href="https://www.newyorker.com/news/our-columnists/why-wont-amnesty-international-call-alexey-navalny-a-prisoner-of-conscience">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inside Xinjiang’s Prison State</strong> - Survivors detail the scope of China’s campaign of persecution against ethnic and religious minorities. - <a href="https://www.newyorker.com/news/a-reporter-at-large/china-xinjiang-prison-state-uighur-detention-camps-prisoner-testimony">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Deportation Nightmare in the Bronx</strong> - Arrested for jaywalking, a DACA recipient spent the pandemic in ICE detention because of what New York City officials admit was an “operational error.” He could be deported as soon as next week. - <a href="https://www.newyorker.com/news/our-local-correspondents/a-deportation-nightmare-in-the-bronx">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Untold Story of Queer Foster Families</strong> - In the nineteen-seventies, social workers in several states placed queer teen-agers with queer foster parents, in discrete acts of quiet radicalism. - <a href="https://www.newyorker.com/news/us-journal/the-untold-story-of-queer-foster-families">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The Republican revolt against democracy, explained in 13 charts</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/HyOuXR9uOtvU_7TuUrysy8nw25M=/167x0:2834x2000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68890366/GettyImages_1304239377.0.jpg"/>
<figcaption>
A visitor wears a face mask with a picture of former President Donald Trump’s mouth on it during the Conservative Political Action Conference on February 26, 2021, in Orlando, Florida. | Joe Raedle/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The Trump years revealed a dark truth: The Republican Party is no longer committed to democracy. These charts tell the story.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DCFdZb">
The Republican Party is the biggest threat to American democracy today. It is a radical, obstructionist faction that has become hostile to the most basic democratic norm: that the other side should get to wield power when it wins elections.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SyXbU7">
A few years ago, these statements may have sounded like partisan Democratic hyperbole. But in the wake of the January 6 attack on the Capitol and Trump’s acquittal in the Senate on the charge of inciting it, they seem more a plain description of where we’re at as a country.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rJ27IB">
But how deep does the GOP’s problem with democracy run, really? How did things get so bad? And is it likely to get worse?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oY0jhj">
Below are 13 charts that illustrate the depth of the problem and how we got here. The story they tell is sobering: At every level, from the elite down to rank-and-file voters, the party is permeated with anti-democratic political attitudes and agendas. And the prospects for rescuing the Republican Party, at least in the short term, look grim indeed.
</p>
<h3 id="DcRFPY">
Today’s Republicans really hate Democrats — and democracy
</h3>
<h4 id="ej3kvt">
<ol type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Trump’s supporters have embraced anti-democratic ideas
</li></ol></h4>
<figure class="e-image">
<img alt="A chart showing overwhelming support among MAGA supporters for election fraud theories and a third term for Trump." src="https://cdn.vox-cdn.com/thumbor/tolIHTTRJkWrWj6epi4gvehA928=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325515/Vy1rP___2_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zPlze1">
This chart shows results from a two-part survey, conducted in late 2020 and early 2021, of hardcore Trump supporters. The political scientists behind the survey, Rachel Blum and Christian Parker, identified so-called “MAGA voters” by their activity on pro-Trump Facebook pages. Their subjects are engaged and committed Republican partisans, disproportionately likely to influence conflicts within the party like primary elections.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gVx33G">
These voters, according to Blum and Parker, are hostile to bedrock democratic principles.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xSwkx5">
They go further than “merely” believing the 2020 election was stolen, a nearly unanimous view among the bunch. Over 90 percent oppose making it easier for people to vote; roughly 70 percent would support a hypothetical third term for Trump (which would be unconstitutional).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XJcNwE">
“The MAGA movement,” Blum and Parker <a href="https://sites.uw.edu/magastudy/">write</a>, “is a clear and present danger to American democracy.”
</p>
<h4 id="HmPCMg">
<ol start="2" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Republicans are embracing violence
</li></ol></h4>
<figure class="e-image">
<img alt="39 percent of Republicans agree that if elected leaders won’t protect America, the people must act, even if that means violence." src="https://cdn.vox-cdn.com/thumbor/SBZs1kH7zUE8wtA4psGkdW_-sIY=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325728/xefMZ___2_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nuHvvL">
The ultimate expression of anti-democratic politics is resorting to violence. More than twice as many Republicans as Democrats — nearly two in five Republicans — said in a January poll that force could be justified against their opponents.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UHRdf7">
It would be easy to dismiss this kind of finding as meaningless were it not for the January 6 attack on Capitol Hill — and the survey was conducted about three weeks <em>after</em> the attack. Republicans recently saw what political violence in the United States looked like, and a large fraction of the party faithful seemed comfortable with more of it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T3d7t8">
These attitudes <a href="https://www.vox.com/policy-and-politics/22217696/republicans-trump-capitol-hill-storming-mob-responsible">are linked to the party elite’s rhetoric</a>: The more party leaders like Trump attack the democratic political system as rigged against them, the more Republicans will believe it and conclude that extreme measures are justifiable. A separate study <a href="https://www.washingtonpost.com/politics/2021/01/11/what-you-need-know-about-how-many-americans-condone-political-violence-why/">by political scientists Lilliana Mason and Nathan Kalmoe</a> found that “Republicans who believe Democrats cheated in the election (83 percent in our study) were far likelier to endorse post-election violence.”
</p>
<h4 id="tE3Mg9">
<ol start="3" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Republicans see Democrats as something worse than mere rivals
</li></ol></h4>
<figure class="e-image">
<img alt="57 percent of Republicans consider Democrats as enemies." src="https://cdn.vox-cdn.com/thumbor/Cvb52qFP0aaunWXnx-xj7Npdxdc=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325743/dF66G___3_.png"/>
</figure>
<figure class="e-image">
<img alt="41 percent of Democrats consider Republicans as enemies." src="https://cdn.vox-cdn.com/thumbor/IUoUSqKnh98QsdU_uexJSiyh2h8=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325742/5q6GH___2_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lGFDFO">
Democracy is, among other things, a system for taming the disagreements inherent in politics: People compete for power under a set of mutually agreeable rules, seeing each other as rivals within a shared system rather than blood enemies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SyU2sU">
But in the United States today, hyperpolarization is undoing this basic democratic premise: Sizable numbers of Americans on each side see the members of the other party not as political opponents but as existential threats.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mHME3X">
The rise of this dangerous species of <a href="https://www.vox.com/mischiefs-of-faction/2017/6/2/15730524/negative-partisanship-toxic-polarization">“negative partisanship,”</a> as political scientists call it, is asymmetric. While many Democrats see Republicans in a dark light, a majority still see them more as political rivals than as enemies. Among Republicans, however, a solid majority see Democrats as their enemy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cyLK85">
When you believe the opposing party to be an enemy, the costs of letting them win become too high, and anti-democratic behavior — rigging the game in your favor, even outright violence — starts to become thinkable.
</p>
<h4 id="FBX7Yr">
<ol start="4" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Republicans dislike compromise
</li></ol></h4>
<figure class="e-image">
<img alt="Majorities of Democrats favored compromise in recent years, until a drop in 2018. Republicans did not." src="https://cdn.vox-cdn.com/thumbor/Dqo1sgljoQQwY2iZiJnZU_92vT8=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325733/8Y1DN___3_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="e7j5sW">
America’s founders designed our political system around compromise. But for years now, majorities of Republican voters have opposed compromise on principle, <a href="https://www.pewresearch.org/politics/2018/04/26/8-the-tone-of-political-debate-compromise-with-political-opponents/">consistently telling pollsters</a> that they prefer politicians who stick to their ideological guns rather than give a little to get things done. It’s no wonder the past decade saw unprecedented Republican obstructionism in Congress (more on that later).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M0zAZF">
The hostility to compromise on the GOP side has at least two major implications for democracy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yCdlsk">
First, it has rendered government dysfunctional and ineffective — and consequently has <a href="https://www.amacad.org/publication/finding-common-good-era-dysfunctional-governance">decreased public trust in government</a>. Second, it has pushed Democrats in a more polarized direction; in 2018, Pew found, Democratic support for political compromise plummeted to roughly Republican levels. This seems in part like a reaction to years of GOP behavior: If they aren’t going to compromise with us, the Democratic logic goes, then why should we compromise with them?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pKilTo">
But the more Democrats eschew compromise, the more cause Republicans have to see them as fundamentally hostile to conservative values — and to redouble their intransigence. It’s a <a href="https://www.vox.com/the-big-idea/2017/9/5/16227700/hyperpartisanship-identity-american-democracy-problems-solutions-doom-loop">doom loop for political coexistence</a>.
</p>
<h4 id="rH1FqM">
<ol start="5" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">The Republican Party is a global outlier — and not in a good way
</li></ol></h4>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/FiG_fUPIf2zfmWSeEBqEHgwST5Y=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325750/EZibQR_WkAM7y4B.jpg"/> <cite><a class="ql-link" href="https://twitter.com/PippaN15/status/1267935819047854080" target="_blank">Pippa Norris/Global Parties Survey</a></cite>
<figcaption>
The Democratic Party does better than the global median on metrics of respect for norms and support for ethnic minority rights. The GOP does far worse.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MzbP7p">
The Global Party Survey is a 2019 <a href="https://www.dropbox.com/s/v7muxl3214xszdq/Party%20Politics%20Measuring%20Populism%20Worldwide%20V2%2028%20Apr%202020.pdf?dl=0">poll of nearly 2,000 experts</a> on political parties from <a href="https://www.globalpartysurvey.org/">around the world</a>. The survey asked respondents to rate political parties on two axes: the extent to which they are committed to basic democratic principles and their commitment to protecting rights for ethnic minorities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Cif8v1">
This chart shows the results of the survey for all political parties in the OECD, a group of wealthy democratic states, with the two major American parties highlighted in red. The GOP is an extreme outlier compared to mainstream conservative parties in other wealthy democracies, like Canada’s CPC or Germany’s CDU. Its closest peers are almost uniformly radical right and anti-democratic parties. This includes Turkey’s AKP (a regime that is <a href="https://cpj.org/reports/2019/12/journalists-jailed-china-turkey-saudi-arabia-egypt/">one of the world’s leading jailers of journalists</a>), and Poland’s PiS (which has <a href="https://freedomhouse.org/article/poland-and-hungary-must-not-be-ignored">threatened dissenting judges with criminal punishment</a>).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cJbyl0">
The verdict of these experts is clear: The Republican Party is one of the most anti-democratic political parties in the developed world.
</p>
<h3 id="2Mgh7P">
How things got this bad
</h3>
<h4 id="DxPWuN">
<ol start="6" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">The Republican turn against democracy begins with race
</li></ol></h4>
<div class="c-float-left">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/Q019KggzPXbgkPZ6iMhwupPNsmI=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325781/F2.large__1_.jpg"/> <cite><a class="ql-link" href="https://www.pnas.org/content/117/37/22752" target="_blank">Larry Bartels</a></cite>
<figcaption>
Republicans with high levels of “ethnic antagonism” generally agree with statements like “It is hard to trust the results of elections when so many people will vote for anyone who offers a handout.”
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s7Dbws">
Support for authoritarian ideas in America is closely tied to the country’s long-running racial conflicts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Wsuto4">
This chart, from a <a href="https://www.pnas.org/content/117/37/22752">September 2020 paper</a> by Vanderbilt professor Larry Bartels, shows a statistical analysis of a survey of Republican voters, analyzing the link between respondents’ score on a measure of “ethnic antagonism” and their support for four anti-democratic statements (e.g., “the traditional American way of life is disappearing so fast that we may have to use force to save it”).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KIlXdU">
The graphic shows a clear finding: The higher a voter scores on the ethnic antagonism scale, the more likely they are to<strong> </strong>support anti-democratic ideas. This held true even when Bartels used regression analyses to compare racial attitudes to other predictors, like support for Trump. “The strongest predictor by far of these antidemocratic attitudes is ethnic antagonism,” he writes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ti9LHc">
For students of American history, this shouldn’t be a surprise.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zLqiZw">
The 1964 Civil Rights Act and 1965 Voting Rights Act cemented Democrats as the party of racial equality, causing racially resentful Democrats in the South and elsewhere to defect to the Republican Party. This sorting process, which took place over the next few decades, is <a href="https://www.amazon.com/Why-Were-Polarized-Ezra-Klein/dp/147670032X">the key reason America is so polarized</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tsbD1S">
It also explains why Republicans are increasingly willing to endorse anti-democratic political tactics and ideas. In the past, restrictions on the franchise served to protect white political power in a changing country; today, as <a href="https://www.vox.com/2016/9/19/12933072/far-right-white-riot-trump-brexit">demographic change threatens to further undermine the central place of white Americans</a>, many are becoming comfortable with an updated version of the Jim Crow South’s authoritarian tradition.
</p>
<h4 id="Gc2Tt9">
<ol start="7" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Partisanship causes Republicans to justify anti-democratic behavior
</li></ol></h4>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/32oZtyCFjcJBPbjgZsjWW9bdQcI=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325799/Screen_Shot_2021_02_24_at_11.48.23_AM.png"/> <cite>Matthew Graham and Milan Svolik</cite>
<figcaption>
This chart looks at early versus in-person voting in the 2017 Montana House special election. After the Republican candidate assaulted a reporter the day before the election, he appears to have lost support in Democratic precincts but saw gains in some heavily Republican ones.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nYsQiu">
This chart is a little hard to parse, but it illustrates a crucial finding from one of the best recent papers on anti-democratic sentiment in America: how decades of rising partisanship made an anti-democratic GOP possible.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0C5myv">
<a href="https://cpb-us-w2.wpmucdn.com/campuspress.yale.edu/dist/6/1038/files/2019/10/Graham-and-Svolik-Democracy-in-America-Partisanship-Polarization-and-the-Robustness-of-Support-for-Democracy-in-the-United-States.pdf">The paper</a>, from Yale’s Matthew Graham and Milan Svolik, uses a number of methods to examine the effect of partisanship on views of democracy. This chart shows a particularly interesting one: a “natural experiment” in Montana’s 2017 at-large House campaign, during which Republican candidate Greg Gianforte assaulted reporter Ben Jacobs during an attempted interview just before Election Day.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f3Ajmj">
Because many voters cast their ballots by mail before the assault happened, Graham and Svolik could compare these to the in-person votes after the assault<strong> </strong>in order to measure how the news of Gianforte’s attack shifted voters’ behavior.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xDRaIq">
The blue lines represent precincts where Gianforte did worse on Election Day than in mail-in ballots; the red lines represent the reverse. What you see is a clear trend: In Democratic-leaning and centrist precincts, Gianforte suffered a penalty. But in general, the more right-leaning a precinct was, the less likely he was to suffer — and the more likely he was to improve on his mail-in numbers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dOy07Y">
For Svolik and Graham, this illustrates a broader point: Extreme partisanship creates the conditions for democratic decline. If you really care about your side wielding power, you’re more willing to overlook misbehavior in their attempts to win it. They find evidence that this could apply to partisans of either major party — but only one party nominates candidates like Trump and Gianforte (who won not only the 2017 contest but also his reelection bid in 2018 and Montana’s gubernatorial election in 2020).
</p>
<h4 id="iGoeeQ">
<ol start="8" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">The crucial impact of the right-wing media
</li></ol></h4>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/MPJTlRdFi-V2RNthsW2mC33nVlM=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325420/Screen_Shot_2021_02_24_at_9.37.15_AM.png"/> <cite><a class="ql-link" href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ajps.12171" target="_blank">Kevin Arceneaux, Martin Johnson, Rene Lindstadt, and Ryan J. Vander Wielen</a></cite>
<figcaption>
In a study covering 1997 to 2002, congressional Republicans in districts where Fox News was available grew considerably more likely to vote with the party as it got closer to election time.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NE9G0b">
The chart here is from <a href="https://blogs.lse.ac.uk/usappblog/2015/04/02/fox-news-pushes-democrats-and-republicans-to-be-more-conservative-especially-around-election-time/">a study covering 1997 to 2002</a>, when Fox News was still being rolled out across the country. The study compared members of Congress in districts where Fox News was available to members in districts where it wasn’t, specifically examining how frequently they voted along party lines.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x9LG9r">
They found that Republicans in districts with Fox grew considerably more likely to vote with the party as it got closer to election time, whereas Republicans without Fox actually grew less likely to do so. The expansion of Fox News, in short, seemingly served a disciplining function: making Republican members of Congress more afraid of the consequences of breaking with the party come election time and thus less inclined to engage in bipartisan legislative efforts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SeLIcn">
“Members with Fox News in their district behave as if they believe that more Republicans will turn out at the polls by increasing their support for the Republican Party,” the authors conclude.
</p>
<h3 id="csVDvZ">
How America’s political system creates space for Republicans to undermine democracy
</h3>
<h4 id="ThV9EH">
<ol start="9" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Republicans have<strong> </strong>an unpopular policy agenda
</li></ol></h4>
<div class="c-float-left">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/uN1U-CsHn83kY_zz8f-rseb_jiw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325842/pasted_image_0__1_.png"/> <cite>Jacob Hacker and Paul Pierson, <em>Let Them Eat Tweets</em></cite>
<figcaption>
Support in polls on major legislation since 1990; Republican bills with tax cuts for wealthy people and Obamacare repeal were especially unpopular.
</figcaption>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uLFjjB">
The Republican policy agenda is extremely unpopular. The chart here, taken from Jacob Hacker and Paul Pierson’s recent book <a href="https://www.amazon.com/Let-them-Eat-Tweets-Inequality/dp/1631496840"><em>Let Them Eat Tweets</em></a>, compares the relative popularity of the two major legislative efforts of Trump’s first term — tax cuts and Obamacare repeal — to similar high-priority bills in years past. The contrast is striking: The GOP’s modern economic agenda is widely disliked even compared to unpopular bills of the past, a finding consistent with a lot of <a href="https://nymag.com/intelligencer/2018/09/republican-memo-admits-voters-oppose-republican-policies.html">recent polling data</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4lTebw">
Hacker and Pierson argue that this drives Republicans’ emphasis on culture war and anti-Democratic identity politics. This strategy, which they term “plutocratic populism,” allows the party’s super-wealthy backers to get their tax cuts while the base gets the partisan street fight they crave.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fL11pD">
The GOP can do this because America’s political system is profoundly unrepresentative. The coalition it can assemble — overwhelmingly white Christian, heavily rural, and increasingly less educated — is a shrinking minority that has lost the popular vote in seven of the past eight presidential contests. But its voters are ideally positioned to give Republicans advantages in the Electoral College and the Senate, allowing the party to remain viable despite representing significantly fewer voters than the Democrats do.
</p>
<h4 id="90uYRT">
<ol start="10" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Some of the most consequential Republican attacks on democracy happen at the state level
</li></ol></h4>
<figure class="e-image">
<img alt="A map showing state voting restrictions enacted 2010-2019, mostly in Republican states." src="https://cdn.vox-cdn.com/thumbor/K18MW-MWa6IhonqS8iSqQgb8lVU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325634/zkR27___3_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fMlkmQ">
This map from the <a href="https://www.brennancenter.org/our-work/research-reports/new-voting-restrictions-america">Brennan Center for Justice</a> shows every state that passed a restriction on the franchise between 2010 and 2019. These restrictions, ranging from voter ID laws to felon disenfranchisement, were generally passed by Republican majorities with the intent of hurting turnout among Democratic-leaning constituencies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7R6Yty">
Republican state legislators were sometimes explicit about this: “Voter ID … is gonna allow Governor Romney to win the state of Pennsylvania,” <a href="https://www.politico.com/story/2012/06/pa-pol-voter-id-helps-gop-win-state-077811">then-state House Majority Leader Mike Turzai bragged during the 2012 presidential election cycle</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JknZmm">
Because Republicans dominated the 2010 midterm elections, Republican statehouses got to control the post-2010 census redistricting process at both the House and state legislative level, leading to extreme gerrymandering in Republican-controlled states unlike anything in Democratic ones.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iFcr7H">
Conservative control of the Supreme Court enabled this state-level push. In 2013, the Court struck down the Voting Rights Act’s “<a href="https://www.vox.com/policy-and-politics/2019/6/25/18701277/shelby-county-v-holder-anniversary-voting-rights-suppression-congress">preclearance</a>” requirement — that states with a history of racial discrimination would be required to get permission from the Justice Department on their maps and other major changes to electoral law. In 2019, another Court ruling <a href="https://www.npr.org/2019/06/27/731847977/supreme-court-rules-partisan-gerrymandering-is-beyond-the-reach-of-federal-court">paved the way</a> for further partisan gerrymandering.
</p>
<h4 id="Jprko2">
<ol start="11" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">The national GOP has broken government
</li></ol></h4>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/Rz0OPywVxusX6ev_yxHu-D7tylI=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325717/HBNUk___3_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wFpA8M">
Today’s Senate, where you need 60 votes to get virtually anything done, is a historical anomaly. Its roots can be traced to the unyielding GOP opposition to President Barack Obama in 2009 and 2010, when Senate Minority Leader Mitch McConnell turned the Senate into a dysfunctional body in which priority legislation was routinely subject to a filibuster. When Republicans won a Senate majority in 2014, McConnell found a new way to deny Obama victories: blocking his judicial appointments.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4AtP99">
These actions were an expression of an attitude popular among Republican voters and leaders alike: that Democrats can never be legitimate leaders, even if elected, and thus do not deserve to wield power.
</p>
<h3 id="5puFez">
<strong>It’s still Trump’s GOP </strong>
</h3>
<h4 id="rWH4qE">
<ol start="12" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Republicans didn’t care when Trump abused his power
</li></ol></h4>
<figure class="e-image">
<img alt="Support for Trump’s first impeachment" src="https://cdn.vox-cdn.com/thumbor/3H303kwkGV4H72oas_n0OoPuzxU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325685/izwwP___5_.png"/>
</figure>
<figure class="e-image">
<img alt="Support for Trump’s second impeachment" src="https://cdn.vox-cdn.com/thumbor/mi2IufpBFEe8z1ZFdt5dvdSmC8g=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325688/gFwVv___3_.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jHRTd5">
The Trump presidency was a test of Republican attitudes toward democracy. Time and again, the president abused his authority in ways that would have been unthinkable under previous presidents. Time and again, members of Congress, state party leaders, right-wing media stars, and rank-and-file voters looked the other way — or even cheered him on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gakkP1">
The chart here, which shows two NBC polls taken about a year apart, is particularly striking. It shows that support for Trump’s first and second impeachment among Republicans remained exactly the same among Republicans: 8 percent.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3JvV0R">
Trump was impeached the first time because he tried to interfere with the integrity of the 2020 presidential election — attempting to strong-arm the Ukrainian president into opening up a bogus investigation into Joe Biden. Trump was impeached the second time because he ginned up a mob to attack the Capitol to disrupt the counting of the votes from the Electoral College.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qUJBTV">
And yet in both cases, the percentage of Republicans who supported impeaching him was the same — a measly 8 percent. There’s just very little popular appetite in the GOP for punishing anti-democratic excesses by Trump, regardless of the circumstances.
</p>
<h4 id="fk1E5S">
<ol start="13" type="1">
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Trump and Trumpism could return in 2024
</li></ol></h4>
<figure class="e-image">
<img alt="54 percent of Republicans support Trump as a potential 2024 presidential primary candidate" src="https://cdn.vox-cdn.com/thumbor/0Ss9R-2q_0Q8bTDB6irVfFZlI68=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22325534/2024.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="07TQuy">
This chart shows the results of a Morning Consult poll on the 2024 Republican primary held after Trump’s second impeachment trial. It found that 54 percent of Republicans would choose Trump again, even when given a wide range of alternative possibilities. Six percent would choose his son Donald Trump Jr. — who obviously wouldn’t run if his father did — putting the Trump family support in the GOP primary electorate at around 60 percent.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h27scA">
This shouldn’t really be surprising.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dNSYlc">
All the reasons for the GOP’s turn against democracy — backlash to racial progress, rising partisanship, a powerful right-wing media sphere — remain in force after Trump. The leadership is still afraid of Trump and the anti-democratic MAGA movement he commands.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="a3pTCm">
More fundamentally, they are still committed to a political approach that can’t win in a majoritarian system, requiring the defense of the undemocratic status quo in institutions like the Senate and in state-level electoral rules. Republicans still control the bulk of statehouses and are gearing up for <a href="https://www.vox.com/22254482/republicans-voter-suppression-state-legislatures">a new round of voter suppression bills and extreme gerrymandering</a> in electorally vital states like Georgia and Texas.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ziat65">
It’s very hard to see how any of this gets better. It’s very easy to see how it gets worse.
</p></li>
<li><strong>The Golden Globes don’t “predict” the Oscars</strong> -
<figure>
<img alt="Sacha Baron Cohen and his wife Isla Fisher onscreen at the Golden Globes." src="https://cdn.vox-cdn.com/thumbor/_Ep709t9yeXG60KYVOmza-JZLUE=/216x0:4864x3486/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/52656855/1304643041.35.jpg"/>
<figcaption>
Sacha Baron Cohen won two Golden Globes for <em>Borat Subsequent Moviefilm</em>. | NBC/NBCU Photo Bank via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Except when they do.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zIysII">
The <a href="https://www.vox.com/22306479/golden-globes-2021-winners-losers">78th Golden Globe Awards</a> were handed out on Sunday, February 28 — about two weeks before the nominations for the 93nd Academy Awards, a.k.a. the Oscars, are set to be announced on Monday, March 15. (The Oscars will take place April 25; the usual timeline was pushed back by about two months this year because of the ongoing Covid-19 pandemic.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MRl451">
The Golden Globes <a href="http://www.vox.com/2016/1/10/10741076/golden-globes-2016-hfpa-explained">are known to be an oddball ceremony</a>, partly due to their open bar. This year they were even weirder than usual, since the pandemic made the customary packed ballroom unsafe. Instead, hosts Tina Fey and Amy Poehler hosted from opposite coasts, joined by a small number of masked and socially distanced front-line workers as guests. Some of the awards presenters took the stage in person; others read nominees’ and winners’ names through a screen. And <a href="https://www.vox.com/culture/22306072/golden-globes-winners-2021-full-list-crown-queens-gambit-schitts-creek">winners</a> accepted their awards from home, beamed into the ceremony via videoconferencing software while all decked out in their ball gowns and tuxes and, in some cases, hoodies.
</p>
<aside id="iOX8BW">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Du8YIK">
This year, the big winners in the film categories were <a href="https://www.vox.com/22289457/nomadland-review-zhao-mcdormand-streaming-hulu"><em>Nomadland</em></a> (Best Drama and Best Director), <a href="https://www.vox.com/culture/21528751/borat-2-subsequent-moviefilm-rudy-giuliani-review-cohen-white-noise"><em>Borat Subsequent Moviefilm</em></a> (Best Comedy or Musical and Best Lead Actor for Sacha Baron Cohen), and <a href="https://www.vox.com/culture/22176927/soul-review-pixar-disney-jazz"><em>Soul</em></a> (Best Animated Film and Best Original Score). The rest of the movie awards were spread out: Netflix’s <a href="https://www.vox.com/culture/22176925/review-ma-raineys-black-bottom-netflix-review"><em>Ma Rainey’s Black Bottom</em></a>, <em>I Care A Lot</em>, and <a href="https://www.vox.com/culture/21515051/trial-of-the-chicago-7-review-sorkin-netflix"><em>The Trial of the Chicago 7</em></a> all took home awards, as did HBO Max’s <a href="https://www.vox.com/22272309/judas-black-messiah-review-hbo-max-black-panthers-kaluuya-stanfield"><em>Judas and the Black Messiah</em></a>, STXfilms’s <em>The Mauritanian</em>,<em> </em>Hulu’s <em>The United States vs. Billie Holiday, </em>and A24’s <a href="https://www.vox.com/22274856/minari-review-yeun-chung"><em>Minari</em></a>.
</p>
<figure class="e-image">
<img alt="NBC’s “78th Annual Golden Globe Awards” - Winners Press Experience" src="https://cdn.vox-cdn.com/thumbor/O45baoDlD3UJ56GKAkR9aNXAW8M=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22336044/1304641556.jpg"/> <cite>NBC/NBCU Photo Bank via Getty Images</cite>
<figcaption>
Chloe Zhao won two Globes for her film <em>Nomadland</em>.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cfTGvK">
It’s tempting to clock any film’s trophy count at the Golden Globes as evidence that the Globes function as an “Oscar predictor.” That’s a natural assumption, because both shows honor movies with a glitzy, star-studded televised ceremony. Plus, the Globes take place about two months before the Oscars and kick off the awards season that culminates in the Oscars.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="68aKoz">
But is there anything to the idea that Globes results predict the eventual Oscar winners?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dE6QUA">
(Note: The awards that the Academy of Motion Picture Arts and Sciences hand out are called “Oscars” <a href="https://en.wikipedia.org/wiki/Academy_Awards#Naming">for reasons that are disputed</a>. But “Oscars” and “Academy Awards” are generally used interchangeably to refer to the ceremony.)
</p>
<h3 id="uKCK9P">
No — because the Golden Globes aren’t set up to be an Oscar predictor
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="okt7jf">
Walt Hickey, <a href="https://fivethirtyeight.com/datalab/golden-globes-oscars-prediction/">writing at FiveThirtyEight</a>, noted that in 2013, the Golden Globes had a success rate of only 48 percent in predicting the Oscars’ eventual<strong> </strong>Best Picture winner.<strong> </strong>That’s not abysmal, but it’s not great either.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="75jjmu">
One of the issues is structural: The Golden Globes give out two Best Picture awards — one for drama and one for musical or comedy — while there’s only one Best Picture Oscar. The awards for Best Actor and Best Actress are also split into drama and comedy/musical categories at the Globes, but the Supporting Actor and Actress categories — along with Best Director and Best Screenplay — are not.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Kjb06y">
Similarly, while the Oscars separate screenplays into Best Original Screenplay and Best Adapted Screenplay, the Globes lump them all into one category.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nR0gE7">
These disparities mean it’s virtually impossible for the Globes to “predict” wins in a meaningful fashion. But the Globes <em>nominations</em> do tend to track near the Oscar nominations (though there are always a few outliers). And since 2010, the Oscars have been able to nominate up to 10 films for Best Picture, making it technically possible for all 10 Golden Globe Best Picture nominees (in both the drama and comedy/musical categories) to also earn a Best Picture nod at the Oscars.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r4dWQe">
Sometimes, the results of the Globes track moderately closely with the Oscar results. In 2019, <em>Green Book</em> won three Golden Globes, including Best Motion Picture – Drama, then went on to win in the three equivalent categories at the Oscars<strong>.</strong> In 2017, the powerhouse <em>La La Land</em> broke records by winning seven awards at the Globes, including Best Motion Picture – Comedy or Musical; it later won six of the 14 Oscars it was nominated for. And <em>Moonlight</em>, which took home the Best Motion Picture – Drama award at the Globes, was the eventual Best Picture winner at the Oscars — <a href="https://www.vox.com/culture/2017/2/27/14748228/oscar-best-picture-moonlight-la-la-land-mixup-beatty-dunaway">though not until after a historic snafu</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lEbdiR">
But as an Oscar predictor, the Globes are still fairly inaccurate, or at least they don’t work in any logical order. The 2020 Best Picture winners at the Globes were <a href="https://www.vox.com/2020/2/6/21123034/1917-one-shot-rope-film"><em>1917</em></a> (in the drama category) and <a href="https://www.vox.com/culture/2019/5/23/18633841/once-upon-time-hollywood-tarantino-review-cannes-pitt-dicaprio-robbie"><em>Once Upon a Time in Hollywood</em></a> (in the comedy or musical category). But at the Oscars, both of those films were bested by <a href="https://www.vox.com/culture/2019/9/13/20864365/parasite-review-bong-joon-ho"><em>Parasite</em></a>, whose Best Picture win at the Globes was in the rarely tapped foreign language category. The 2018 Best Picture winners at the Globes were <a href="https://www.vox.com/2018/1/19/16878018/three-billboards-controversy-racist-sam-rockwell-redemption-flannery-oconnor"><em>Three Billboards Outside Ebbing, Missouri</em></a> (in the drama category) and <a href="https://www.vox.com/2017/11/2/16552860/lady-bird-review-saoirse-ronan-greta-gerwig"><em>Lady Bird</em></a> (in the comedy or musical category) — but both missed the major awards at the Oscars. And two years prior, in 2016, <em>The Revenant</em> won the Golden Globe for Best Drama, beating out eventual Oscars Best Picture winner <em>Spotlight. </em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RQm0g2">
There are plenty of other categories at the Globes, however, and the awards have a much better track record when it comes to predicting the Oscars’ Best Actor and Actress winners. In January 2016, <a href="http://flavorwire.com/555072/do-the-golden-globes-really-predict-the-oscars">Jason Bailey found at Flavorwire</a> that over the past decade, the Globes boasted a nearly 90 percent accuracy rating for predicting the Oscars’ acting awards, versus Best Director (40 percent) or Best Picture (50 percent).
</p>
<figure class="e-image">
<img alt="Daniel Kaluuya looks straight into the screen." src="https://cdn.vox-cdn.com/thumbor/YJh0RURugHy2qCTiEHywAjvINUs=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22336055/1304625909.jpg"/> <cite>NBC/NBCU Photo Bank via Getty Images</cite>
<figcaption>
Daniel Kaluuya won for his performance in <em>Judas and the Black Messiah</em>. Will he repeat it at the Oscars?
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V7litl">
But if you’re looking to win your Oscar pool this year, you’re best off also checking who ultimately wins the top prizes at the various guilds: The Directors Guild of America (DGA) and Producers Guild of America (PGA) are typically the strongest predictors of the eventual Oscars Best Picture winner; the Screen Actors Guild Awards (given out by SAG-AFTRA) is usually the place to check for performance frontrunners (alongside the BAFTAs and the Globes); the Writers’ Guild (WGA) helps predict the screenwriting awards; and so on. <a href="https://fivethirtyeight.com/features/fivethirtyeights-guide-to-predicting-the-oscars/">FiveThirtyEight’s prediction model from 2016 has a great rundown</a>.
</p>
<h3 id="Yd8BJE">
No — because the people who vote for the Golden Globes don’t overlap with the people who vote for the Oscars
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g94LxU">
The reason for the overlap with industry-specific awards is simple: A high percentage of the people who vote for the Academy Awards also belong to guilds like the DGA, PGA, SAG-AFTRA, and WGA. So people’s votes often overlap, disparate categories notwithstanding.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LHwkBd">
The people who vote for the Golden Globes, however, are an entirely different group, and they’re not industry voters. The Hollywood Foreign Press Association hands out the Golden Globes, and there is virtually no overlap between the HFPA and the Academy.
</p>
<aside id="kfAXum">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uShHH0">
In brief: The membership of the HFPA never surpasses 100 and is ostensibly made up entirely of journalists based in Southern California who work for foreign publications — though even <a href="http://www.vox.com/2016/1/10/10741076/golden-globes-2016-hfpa-explained">that status is hard to verify in a few cases</a>. Currently, its membership <a href="https://www.latimes.com/entertainment-arts/business/story/2021-02-21/hfpa-golden-globes-2021-who-are-the-members">numbers 87</a>.<strong> </strong>That small membership means it’s known for being unpredictable, and it’s <a href="https://www.vox.com/22301883/golden-globes-2021-bad-corrupt-emily-paris-music-minari">sometimes accused</a> of letting publicity and favors <a href="http://www.vox.com/2016/1/10/10747362/denzel-washington-golden-globes-corruption">skew the results</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3xQl2A">
The Academy, on the other hand, is made up of <a href="https://ew.com/awards/oscars/academy-invites-819-members-hits-diversity-goals-2020-class/">nearly 10,000 members</a>, all of whom work or previously worked in the filmmaking business in some capacity or another — actors, directors, producers, screenwriters, and more. Academy voters still skew overwhelmingly white, male, and over 60, but <a href="http://www.vox.com/2016/1/22/10816542/academy-awards-boycott-rules-changes">new rules instituted in 2016</a> (after <a href="http://www.vox.com/2016/1/14/10767662/oscar-nominations-2016-so-white">the #OscarsSoWhite controversy</a>) are changing that.
</p>
<h3 id="7kp1JU">
But then again, maybe
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="buVeCt">
The thing about awards buzz is that it’s generated by journalists and critics, and also by the way film studios try to market their films to voters. A great deal of this happens through the distribution of<strong> </strong>screeners for major films, which are sent to people who belong to major voting bodies (guilds and critics’ circles, as well as the Academy) to help ensure they can watch as many films as possible and aid them in filling out their ballots.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/5vj0ia3qeL0hQ_xsyF2HyUjPKcw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22336063/1304637107.jpg"/> <cite>NBC/NBCU Photo Bank via Getty Images</cite>
<figcaption>
Writer and director Lee Isaac Chung accepts the award for Best Motion Picture – Foreign Language for <em>Minari</em>.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7i8Pd8">
In 2021, voting members of the Academy must submit their Oscar nomination ballots by Friday, March 5 — only five days after the Golden Globes. And given how wild and confusing this awards season has been, it’s reasonable to bet that plenty of Oscar voters still have a stack of screeners sitting on their coffee tables as you read this.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SwRgpu">
So while they’ve probably watched the favorites by now — <em>Nomadland</em> and <em>The Trial of the Chicago 7</em> and <em>One Night in Miami</em> — a Golden Globes win for an underdog like <em>I Care A Lot </em>or<em> The Mauritanian</em> might push a voter to give the film or performance another look in what little time remains before they must submit their ballot. And thus, Rosamund Pike or Jodie Foster, both of whom have been part of awards conversations but not frontrunners in the Best Actress category, may still have a chance; you never know.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sWA3ph">
That means that while the Golden Globes aren’t established<strong> </strong>“predictors” for the Oscars, they can still <em>influence</em> the Oscars. A surprise win at the Globes, if it inspires enough Academy members to watch a film they haven’t yet seen, or to reconsider a film or performance they had forgotten about, could give a film the extra nudge it needs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JVs7Y4">
And in 2021, that matters, because at this point it’s anyone’s guess as to what will happen between now and the end of April, when Hollywood convenes (probably largely virtually) for the Oscars. In a year when Oscar buzz has been muted without the usual rounds of red carpet premieres, parties, meet-and-greets, and <a href="https://www.vox.com/culture/2019/2/21/18229512/oscar-campaigns-for-your-consideration-events-narratives-weinstein">relentless campaigning</a> — and when films that wouldn’t normally seem like Oscar bait, like <em>Borat Subsequent Moviefilm</em>, are taking home trophies — the field feels wide open.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZnXi2N">
So, nobody really knows. <em>Nomadland</em>’s and <em>Borat Subsequent Moviefilm</em>’s big night at the 2021 Golden Globes could be an indicator of future success, or it may not have any bearing at all. Other films that won big at the Globes may enjoy a boost. And that’s why, <a href="https://www.vox.com/22301883/golden-globes-2021-bad-corrupt-emily-paris-music-minari">seemingly against all reason and sense</a>, we keep talking about the Golden Globes.
</p></li>
<li><strong>The 2021 Golden Globes proved we no longer need the Golden Globes</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/kdRE8AmoKM2mlZxp88jqQnHuuNs=/0x0:4304x3228/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68889782/1304633232.0.jpg"/>
<figcaption>
Rosamund Pike reacts to winning the Golden Globe for Best Actress in a Motion Picture – Musical or Comedy via livestream at the 2021 Golden Globes. | Kevin Mazur/Getty Images for Hollywood Foreign Press Association
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The stranger-than-ever ceremony was also a drag.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wQNZtD">
Nobody “went home” from the <a href="https://www.vox.com/golden-globes">2021 Golden Globes</a> with an award, because pretty much <a href="https://www.vox.com/culture/22306072/golden-globes-winners-2021-full-list">everyone who won a trophy</a> was already at their house. Thanks to the ongoing Covid-19 pandemic, the <a href="https://www.vox.com/22301883/golden-globes-2021-bad-corrupt-emily-paris-music-minari">always-bizarre ceremony</a> was even weirder than usual this year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rH1gM1">
There were a handful of big winners. Netflix’s <em>The Crown</em> netted four awards: three for stars Emma Corrin, Gillian Anderson, and Josh O’Connor, plus the title of Best TV Series – Drama. The streaming network did well overall, raking in honors for <em>The Trial of the Chicago 7</em> (Best Screenplay, Aaron Sorkin); <em>I Care a Lot</em> (Best Actress in a Motion Picture – Musical or Comedy, Rosamund Pike); <em>The Life Ahead </em>(Best Original Song); <em>The Queen’s Gambit</em> (Best Limited TV Series and Best Actress in a Limited Series, Anya Taylor-Joy); and <em>Ma Rainey’s Black Bottom</em> (Best Actor in a Motion Picture – Drama, Chadwick Boseman).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c0YIa6">
Other wins were more spread out. Pixar’s <em>Soul </em>won Best Animated Film and Best Original Score. <em>Borat Subsequent Moviefilm </em>won Best Motion Picture – Musical or Comedy, as well as Best Actor in a Motion Picture – Musical or Comedy for Sacha Baron Cohen’s lead performance. And Chloé Zhao won both Best Director and Best Motion Picture – Drama for <em>Nomadland</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7K1X3e">
There were also a few great moments. Taylor Simone Ledward, wife of the late Chadwick Boseman, gave a moving speech about what her husband would have said if he’d been there to accept his award for <em>Ma Rainey’s Black Bottom</em>:
</p>
<div id="nekixV">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Watch Chadwick Boseman’s wife, Taylor Simone Ledward, accept the late actor’s <a href="https://twitter.com/hashtag/GoldenGlobes?src=hash&amp;ref_src=twsrc%5Etfw">#GoldenGlobes</a> win <a href="https://t.co/gMrpbjjqwe">https://t.co/gMrpbjjqwe</a> <a href="https://t.co/Wx1jjdugXU">pic.twitter.com/Wx1jjdugXU</a>
</p>
— Variety (<span class="citation" data-cites="Variety">@Variety</span>) <a href="https://twitter.com/Variety/status/1366232837729308678?ref_src=twsrc%5Etfw">March 1, 2021</a>
</blockquote></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zf4zig">
And Jane Fonda, who received the Cecil B. DeMille Award for her outstanding contributions to entertainment, praised many of the year’s best films and exhorted the audience regarding the stories they tell. “There’s a story we’ve been afraid to see and hear about ourselves in this industry, a story about which voices we respect and elevate and which we tune out, a story about who is offered a seat at the table and who is kept out of the rooms where decisions are made,” she said. “So let’s all of us, including all the groups that decide who gets hired and what gets made and who wins awards, let’s all of us make an effort to expand that tent so that everyone rises and everyone’s story has a chance to be seen and heard.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sidsdp">
Yet the overwhelming feeling at the end of the Golden Globes is one of … limpness. Certainly, without some of the glamour and in-person excitement, the show was bound to feel weird.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iOstEa">
But why did it feel like the Golden Globes spent the whole evening arguing for their own irrelevance? The best you can say about the sketch comedy bits was that they felt like they were trying <em>really</em> hard. The awkward cutaways to nominees chatting on video screens felt forced and strange. It was never really clear why the ceremony had to air live, when most of the acceptance speeches would have been just as effectively shared as an Instagram Story. And the weirdest part of all was that these issues weren’t really new. So are the “normal” Golden Globes still worthwhile?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7Fi5Fl">
We say no. Here are three reasons why.
</p>
<aside id="pnzAVd">
<div>
</div>
</aside>
<h3 id="VWFR68">
Reason 1: This year’s show was awful
</h3>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/51TXlxFYAT9Ri-ADQDkv9NsiwLU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22336124/1304644897.jpg"/> <cite>NBC/NBCU Photo Bank via Getty Images</cite>
<figcaption>
Daniel Kaluuya’s speech could not be heard for several seconds after he won the award for Best Supporting Actor in a Motion Picture.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WplCzk">
Did the 78th Golden Globe Awards have their bright spots? Sure.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="labceO">
Tina Fey and Amy Poehler’s bicoastal hosting job was plagued with weird timing mishaps, but they landed several funny jokes in spite of the technical issues. Fonda’s speech accepting the Cecil B. DeMille Award was a terrific call for better diversity in Hollywood that doubled as a humblebrag about how many awards screeners she’s managed to watch in quarantine. And getting a glimpse into stars’ homes thanks to videoconferencing software is still a lot of fun. (<em>Nomadland</em>’s Zhao best fit the evening’s aesthetic in a sweatshirt, her hair in long braids. She had a very “I am watching the Golden Globes for no particular reason” vibe.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vqyx1F">
But by and large, the Globes were an awful awards show that proved nobody involved in the production had bothered, say, to watch the Emmy Awards, which were held last September under very similar circumstances (a global pandemic led to hundreds of live feeds from nominees’ homes) but which managed to put on a much, much, much more entertaining telecast.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BOpuD3">
If the Globes wanted to set low expectations, they started right out of the gate. The night’s opening award — Daniel Kaluuya winning Supporting Actor in a Motion Picture for his work in <em>Judas and the Black Messiah</em> — featured a lengthy portion when Kaluuya was clearly speaking but viewers could not hear him, and producers briefly tried to shut down his speech altogether.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qa52qJ">
Similar technical mishaps popped up throughout, with Fey and Poehler occasionally stepping over each other and the show trying to play off several winners with loud music that didn’t seem to have the desired effect, leading to a weirdly chaotic scene of people talking in their homes while music played over them, with neither element especially audible. The sound and lighting quality for the various nominees scattered all over the planet was … variable, to say the least.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="INwvGx">
But even beyond technical issues, these Globes were particularly bad. The choice to end every segment with video windows of the five nominees up for the next award made some degree of sense, but then they were made to chat with each other, as if to find a way to suggest that stars are just like you and don’t quite know what to say to their coworkers on Zoom. Some gamely tried to get a conversation going; others just smiled placidly while they waited for something else to happen.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cAJzG8">
The 2020 Emmys were far from perfect, but they went off largely without a hitch, and the team behind that show clearly thought out how to direct traffic during a live event being carried out in multiple locations. The Golden Globes, with months of lead time, clearly didn’t put much effort into measuring up. And to be clear: These are the <em>Emmys</em> we’re talking about. The famously terrible Emmys.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wzQAVD">
Some of that inability to find the right tone for the evening surely stems from an attempt to recreate a boozy awards show of old (more on that below). But first, we need to look at the shoe hanging over the evening’s affairs, just waiting to drop: the investigative reporting from this year that has shown the Hollywood Foreign Press Association to be a non-diverse, absurdly corrupt institution.
</p>
<h3 id="kBVbxS">
Reason 2: The HFPA seemed constantly aware that it’s a terrible organization
</h3>
<figure class="e-image">
<img alt="NBC’s “78th Annual Golden Globe Awards” - Red Carpet Arrivals" src="https://cdn.vox-cdn.com/thumbor/h4Rk879DjaVNbHPz2PE9PBw0bO0=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22335913/1304609061.jpg"/> <cite>Todd Williamson/NBC/NBCU Photo Bank via Getty Images</cite>
<figcaption>
HFPA Board Chair Meher Tatna, HFPA President Ali Sar, and HFPA Vice President Helen Hoehne on the red carpet.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="StojhH">
The organization that gives out the Golden Globes, the Hollywood Foreign Press Association (HFPA), came into this year’s ceremony unusually embattled. The group’s membership consists of about 90 people, and they’re supposed to all be journalists who write about Hollywood for non-American outlets.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5fBo3C">
But a <a href="https://www.latimes.com/entertainment-arts/business/story/2021-02-21/hfpa-golden-globes-2021">Los Angeles Times investigation</a> published a week ahead of the event detailed a history of unethical practices and turmoil. Another LA Times story revealed that <a href="https://www.latimes.com/entertainment-arts/business/story/2021-02-21/hfpa-golden-globes-2021-who-are-the-members">none of the HFPA’s current members are Black</a>. In fact, the HFPA, which doesn’t publish the names of its members, admitted just ahead of the ceremony that they hadn’t had a Black member in their ranks <a href="https://variety.com/2021/awards/awards/golden-globes-no-black-members-hfpa-1234916590/">in 20 years</a>. As the ceremony approached, <a href="https://www.latimes.com/entertainment-arts/movies/story/2021-02-28/hollywood-foreign-press-diversity-black-members-norman-lear">calls for the organization to become more inclusive grew louder</a>. And those calls were echoed during the ceremony itself.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3vCmFl">
HFPA Board Chair Meher Tatna, HFPA President Ali Sar, and HFPA Vice President Helen Hoehne stood onstage early in the evening <a href="https://ew.com/awards/golden-globes/hfpa-addresses-lack-black-voters-golden-globes/?utm_campaign=entertainmentweekly_entertainmentweekly&amp;utm_content=manual&amp;utm_medium=social&amp;utm_source=twitter.com&amp;utm_term=603c50d3f66bb20001bfbf6c">and pledged</a>, without specifics, to do better and become more inclusive. But even if the HFPA leadership hadn’t said anything onstage, the night’s hosts and presenters would have made sure they couldn’t miss the point.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g3aam4">
Fey and Poehler called out the organization immediately at the top of the telecast, with Fey referring to the HFPA as “around 90 international (no Black) journalists.” While accepting the award for Best Motion Picture – Comedy or Musical for <em>Borat Subsequent Moviefilm</em>, Sacha Baron Cohen (hyperbolically) referred to the organization as “the all-white Hollywood Foreign Press.” Sterling K. Brown, who came onstage as a presenter with his <em>This Is Us</em> co-star Susan Kelechi Watson, proclaimed, “It’s great to be Black — back — at the Golden Globes.” Dan Levy, accepting the award for Best TV Series – Musical or Comedy for <em>Schitt’s Creek</em>, said, “In the spirit of inclusion, I hope this time next year this ceremony reflects the true breadth and diversity of film and television being made today because there is so much more to be celebrated.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZMjMwg">
It remains to be seen what the Globes will do going forward. The bigger question, though, may be whether adding Black members to its ranks will be more than just a Band-Aid, an effort to distract from the organization’s big problems with kickbacks and corruption.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="n5kRBA">
The HFPA makes most of its money and draws most of the Golden Globes’ prestige from the fact that NBC pays the group millions of dollars for the rights to broadcast the awards show. If people stop watching, or if stars decline to participate, that revenue stream — and what remains of the show’s clout — will fall apart.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kWjWwo">
At present, the HFPA’s public promise to diversify its membership seems poised to mollify anyone who might be getting restless about the Globes’ place near the top of the awards show heap. But there’s no guarantee its efforts will amount to anything more than lip service. And given the HFPA’s failure to address the allegations of corruption, you have to wonder if there’s more dissent in their future.
</p>
<h3 id="askBts">
Reason 3: Without booze, why watch this show?
</h3>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/k_4U-WiaQ5R4LyxGe5wrj5eALVU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22336119/1304639353.jpg"/> <cite>Handout/HFPA via Getty Images</cite>
<figcaption>
Jason Sudeikis accepts his award for Best Performance by an Actor in a Television Series – Musical or Comedy at the Golden Globes.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="63lzD4">
The most prevalent reason to watch the Golden Globes has always boiled down to: The stars get drunk! Don’t like the lugubrious, stately snore that is the Oscars? Find the weird chaos of the Emmys overwhelming? Well, the Golden Globes are the awards show that doesn’t take itself seriously! Beautiful people get buzzed and make speeches! It’s fun to see!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HLuQ6L">
The Globes have always made idiosyncratic choices that often seem intended to get more and bigger stars to attend. Those idiosyncratic choices in and of themselves rarely have rhyme or reason to them, but if you land the right mix of tipsy stars and a host with a nice buzz going, you can get some pretty fun television out of the whole deal. The awards almost don’t matter.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MFAq4n">
But that’s just it: The awards almost don’t matter. The Globes serve as a kind of informal kickoff to awards season. Even though other prizes are handed out well before the Globes are, those other prizes are not presented on television, which means that for many people with a casual interest in Hollywood acclaim, the Globes are where it all begins, the Iowa caucuses of awards season, if you will.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F2bGfo">
And like the caucuses, the slightest of mishaps can easily expose the inherent weaknesses in the system underpinning them. The pandemic-addled 2021 awards revealed just how shaky the Globes are as an awards show to begin with. The comedic bits were particularly rough (outside of Poehler and Fey’s occasional one-liners), the speeches went on and on and on, and the show was too preoccupied with figuring out why it was even happening to just settle down and have a good time.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZGaW6j">
One moment in the broadcast’s second half particularly stands out as an example of this. Jason Sudeikis, clearly surprised to have won the Golden Globe for Best Actor in a Musical or Comedy Series for his work on <em>Ted Lasso </em>and clearly feeling the wee early hours in the United Kingdom (where <em>Ted Lasso</em> is shooting its second season), stammered through a long acceptance speech that contained numerous false starts and never quite found its footing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NbtUvt">
Don Cheadle, nominated in the same category for Showtime’s <em>Black Monday</em>, made a circular motion with his finger to try to get Sudeikis to wrap it up. Sudeikis gamely played along, saying that, yes, he needed to wrap things up. But where the moment might have had some comedic zip to it in person as the two actors fed off each other, it fell flat over videoconferencing software. Rather than a potential burst of comedic inspiration, it was a desperate moment of two actors trying to save what already felt like a punishingly long ceremony from slipping even further into boredom.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WmF1y0">
The Golden Globes are a hidebound institution that should probably be junked in favor of something else. It’s doubtful they could do anything bad enough to actually lose their contract with NBC or their solid viewership. But if any Golden Globes ceremony was going to risk sending the awards down the tank, it was this one. The 2021 Golden Globes were simply putrid. Maybe it’s time to come up with something new.
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Too much ‘moaning and groaning’ about Motera pitch: Viv Richards slams critics of Indian tracks</strong> - The West Indian batting legend says England didn’t prepare well for the challenge in India and should work harder and learn to adapt</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vijender Singh’s next pro bout on rooftop deck of casino ship in Goa</strong> - His opponent will be announced later</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tiger Woods thanks golfers for red shirt tribute</strong> - An 82-time PGA Tour winner, Woods famously wears a red shirt and black trousers on Sundays.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Premier League | Man Utd frustrated by penalty row in Chelsea stalemate, Bale stars for Spurs</strong> - A Curtis Jones strike and a Kean Bryan own goal gave Liverpool a 2-0 win over bottom side Sheffield United.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India vs England | Rohit has proved himself in tougher home conditions</strong> - The India opener has emerged as a reliable batsman in overseas Tests as well, as evidenced in his performance Down Under</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus | India reported 106 deaths in the last 24 hours</strong> - Maharashtra, Kerala, Punjab, Karnataka, Tamil Nadu and Gujarat have shown a surge in new COVID-19 cases in the last 24 hours</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>‘We are not part of it,’ says Veerappa Moily, distancing himself from ‘G-23’ Jammu meet</strong> - Veerappa Moily was one of the group of 23 leaders who wrote to Sonia Gandhi in August last year urging her to ensure “full-time” and “visible” leadership</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cheppad church now monument of national importance</strong> - ASI writes to NHAI to propose new alignment for widening National Highway 66</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Maharashtra govt can cut taxes, reduce fuel prices, says Devendra Fadnavis</strong> - Maharashtra BJP leader Devendra Fadnavis on March 1 said the MVA government in the State was misleading people on fuel price hikes as it can cut taxe</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bhima Koregaon case: Supreme Court to hear bail plea of activist Navlakha on March 3</strong> - A three judge Bench of the apex court comprising justices U.U. Lalit, Indira Banerjee and K.M. Joseph would take up the appeal of Navlakha.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Armenia opposition breaks into government building</strong> - Armenia’s embattled PM is now in open dispute with the armed forces chiefs.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Barcelona: Catalan police make several arrests over financial issues at Spanish club</strong> - Catalan police make several arrests after searching the offices of La Liga side Barcelona.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sarkozy: French verdict due in ex-president’s corruption trial</strong> - Ex-President Nicolas Sarkozy denies wrongdoing in a case involving a lawyer and judge.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why this teen set up a prize-winning fake cosmetics shop</strong> - Polish teenager Krystyna Paszko’s idea won an EU prize - she tells the BBC the story behind it.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: False vaccine claims debunked</strong> - Misleading claims about coronavirus vaccines have been spreading online.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Action-packed meta-fantasy, space opera herald a bright future for Asian film</strong> - Chinese <em>A Writer’s Odyssey</em> and Korean <em>Space Sweepers</em> make for a great double feature - <a href="https://arstechnica.com/?p=1744709">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>All the little things that add up to make iPadOS productivity a pain</strong> - Apple did a good job with the big stuff, but myriad little things undermine that. - <a href="https://arstechnica.com/?p=1744614">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inside the stunning Black mythos of Drexciya and its Afrofuturist ’90s techno</strong> - The history of an experimental music-and-mythos project with Black Diaspora at its core. - <a href="https://arstechnica.com/?p=1743849">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clubhouse’s security and privacy lag behind its explosive growth</strong> - The platform has promised to do better after a string of incidents. - <a href="https://arstechnica.com/?p=1745770">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FDA authorizes J&amp;J COVID vaccine after unanimous vote [Updated]</strong> - An FDA advisory committee voted Friday 22-0 in favor of authorization. - <a href="https://arstechnica.com/?p=1745814">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
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<li><strong>A German girl married a Spanish man</strong> - <!-- SC_OFF -->
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A German girl married a Spanish man &amp; went to Spain. She can’t speak Spanish. Each time she wants to buy chicken legs, she would lift her skirt&amp; show her thighs to enable the seller understand her.
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This went on for sometime. One day she wanted to buy banana. So She took her husband to the shop. Because her husband speaks Spanish very well.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/kgangadhar"> /u/kgangadhar </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lule55/a_german_girl_married_a_spanish_man/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lule55/a_german_girl_married_a_spanish_man/">[comments]</a></span></p></li>
<li><strong>Nobody will upvote a cake joke in my birthday</strong> - <!-- SC_OFF -->
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I feel desserted.
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​
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Happy cake day to me :)
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/neocraven"> /u/neocraven </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lv4ptt/nobody_will_upvote_a_cake_joke_in_my_birthday/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lv4ptt/nobody_will_upvote_a_cake_joke_in_my_birthday/">[comments]</a></span></p></li>
<li><strong>I own the world’s worst thesaurus.</strong> - <!-- SC_OFF -->
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Not only is it awful, it’s awful.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Kartikey15"> /u/Kartikey15 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/luzj5x/i_own_the_worlds_worst_thesaurus/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/luzj5x/i_own_the_worlds_worst_thesaurus/">[comments]</a></span></p></li>
<li><strong>A man receives a message from a neighbour.</strong> - <!-- SC_OFF -->
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“Sorry sir I am using your wife…day and night… When you are not present at home…In fact, much more than you do. I confess this now because I am feeling very guilty. Hope you will accept my sincere apologies.” The man is down with a heart attack and admitted to the hospital
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The next day he receives another message<br/> “Sorry sir spelling mistake, it’s not wife but wifi”.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/nabimchord"> /u/nabimchord </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lv0wr4/a_man_receives_a_message_from_a_neighbour/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lv0wr4/a_man_receives_a_message_from_a_neighbour/">[comments]</a></span></p></li>
<li><strong>Don’t you dare hit that drum again!</strong> - <!-- SC_OFF -->
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If you do, there will be repercussions!
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lv4ilz/dont_you_dare_hit_that_drum_again/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lv4ilz/dont_you_dare_hit_that_drum_again/">[comments]</a></span></p></li>
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