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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy</strong> -
<div>
The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to global health. We previously reported that AAK1, BIKE and GAK, members of the Numb-associated kinase family, control intracellular trafficking of multiple RNA viruses during viral entry and assembly/egress. Here, using both genetic and pharmacological approaches, we probe the functional relevance of NAKs for SARS-CoV-2 infection. siRNA-mediated depletion of AAK1, BIKE, GAK, and STK16, the fourth member of the NAK family, suppressed SARS-CoV-2 infection in human lung epithelial cells. Both known and novel small molecules with potent AAK1/BIKE, GAK or STK16 activity suppressed SARS-CoV-2 infection. Moreover, combination treatment with the approved anti-cancer drugs, sunitinib and erlotinib, with potent anti-AAK1/BIKE and GAK activity, respectively, demonstrated synergistic effect against SARS-CoV-2 infection in vitro. Time-of-addition experiments revealed that pharmacological inhibition of AAK1 and BIKE suppressed viral entry as well as late stages of the SARS-CoV-2 life cycle. Lastly, suppression of NAKs expression by siRNAs inhibited entry of both wild type and SARS-CoV-2 pseudovirus. These findings provide insight into the roles of NAKs in SARS-CoV-2 infection and establish a proof-of-principle that pharmacological inhibition of NAKs can be potentially used as a host-targeted approach to treat SARS-CoV-2 with potential implications to other coronaviruses. Keywords: SARS-CoV-2, Numb-associated kinases, kinase inhibitors, host-targeted antivirals
</div></li>
</ul>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.03.18.484178v1" target="_blank">Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy</a>
</div>
<ul>
<li><strong>Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells</strong> -
<div>
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a {beta}-galactoside-binding lectin involved in immune regulation and viral immunopathogenesis, were reported to be elevated in the setting of severe COVID-19 disease. However, the impact of Gal-9 on SARS-CoV-2 infection and immunopathology remained to be elucidated. Here, we demonstrate that Gal-9 treatment potently enhances SARS-CoV-2 replication in human airway epithelial cells (AECs), including primary AECs in air-liquid interface (ALI) culture. Gal-9 promotes SARS-CoV-2 attachment and entry into AECs in an ACE2-dependent manner, enhancing the binding affinity of the viral spike protein to ACE2. Transcriptomic analysis revealed that Gal-9 and SARS-CoV-2 infection synergistically induced the expression of key pro-inflammatory programs in AECs including the IL-6, IL-8, IL-17, EIF2, and TNF signaling pathways. Our findings suggest that manipulation of Gal-9 should be explored as a therapeutic strategy for SARS-CoV-2 infection.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.03.18.484956v1" target="_blank">Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells</a>
</div></li>
<li><strong>Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine</strong> -
<div>
Despite the remarkable efficacy of COVID-19 vaccines, waning immunity, and the emergence of SARS-CoV-2 variants such as Omicron represents a major global health challenge. Here we present data from a study in non-human primates demonstrating durable protection against the Omicron BA.1 variant induced by a subunit SARS-CoV-2 vaccine, consisting of RBD (receptor binding domain) on the I53-50 nanoparticle, adjuvanted with AS03, currently in Phase 3 clinical trial (NCT05007951). Vaccination induced robust neutralizing antibody (nAb) titers that were maintained at high levels for at least one year after two doses (Pseudovirus nAb GMT: 2207, Live-virus nAb GMT: 1964) against the ancestral strain, but not against Omicron. However, a booster dose at 6-12 months with RBD-Wu or RBD-B (RBD from the Beta variant) displayed on I53-50 elicited equivalent and remarkably high neutralizing titers against the ancestral as well as the Omicron variant. Furthermore, there were substantial and persistent memory T and B cell responses reactive to Beta and Omicron variants. Importantly, vaccination resulted in protection against Omicron infection in the lung (no detectable virus in any animal) and profound suppression of viral burden in the nares (median peak viral load of 7567 as opposed to 1.3x107 copies in unvaccinated animals) at 6 weeks post final booster. Even at 6 months post vaccination, there was significant protection in the lung (with 7 out of 11 animals showing no viral load, 3 out of 11 animals showing ~20-fold lower viral load than unvaccinated controls) and rapid control of virus in the nares. These results highlight the durable cross- protective immunity elicited by the AS03-adjuvanted RBD-I53-50 nanoparticle vaccine platform.
</div>
<div class="article- link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.03.18.484950v1" target="_blank">Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine</a>
</div></li>
<li><strong>Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In Spike</strong> -
<div>
To provide a unique global view of the relative potential for evasion of CD8+ and CD4+ T cells by SARS- CoV-2 lineages as they evolve over time, we performed a comprehensive analysis of predicted HLA-I and HLA-II binding peptides in spike (S) and nucleocapsid (N) protein sequences of all available SARS-CoV-2 genomes as provided by NIH NCBI at a bi-monthly interval between March and December of 2021. A data supplement of all B.1.1.529 (Omicron) genomes from GISAID in early December was also used to capture the rapidly spreading variant. A key finding is that throughout continued viral evolution and increasing rates of mutations occurring at T-cell epitope hotspots, protein instances with worst case binding loss did not become the most frequent for any Variant of Concern (VOC) or Variant of Interest (VOI) lineage; suggesting T-cell evasion is not likely to be a dominant evolutionary pressure on SARS-CoV-2. We also determined that throughout the course of the pandemic in 2021, there remained a relatively steady ratio of viral variants that exhibit conservation of epitopes in the N protein, despite significant potential for epitope loss in S relative to other lineages. We further localized conserved regions in N with high epitope yield potential, and illustrated HLA-I binding heterogeneity across the S protein consistent with empirical observations. Although Omicron’s high volume of mutations caused it to exhibit more epitope loss potential than most frequently observed versions of proteins in almost all other VOCs, epitope candidates across its most frequent N proteins were still largely conserved. This analysis adds to the body of evidence suggesting that N may have merit as an additional antigen to elicit immune responses to vaccination with increased potential to provide sustained protection against COVID-19 disease in the face of emerging variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.03.18.484954v1" target="_blank">Peptidome Surveillance Across Evolving SARS-CoV-2 Lineages Reveals HLA Binding Conservation in Nucleocapsid Among Variants With Most Potential for T-Cell Epitope Loss In Spike</a>
</div></li>
<li><strong>A Novel High-Throughput Single B-Cell Cloning Platform for Isolation and Characterization of High-Affinity and potent SARS-CoV-2 Neutralizing Antibodies</strong> -
<div>
Monoclonal antibodies (mAbs) that are specific to SARS-CoV-2 can be useful in diagnosing, preventing, and treating the coronavirus (COVID-19) illness. Strategies for the high-throughput and rapid isolation of these potent neutralizing antibodies are critical toward the development of therapeutically targeting COVID-19 as well as other infectious diseases. In the present study, a single B-cell cloning method was used to screen SARS-CoV-2 receptor-binding domain (RBD) specific, high affinity, and neutralizing mAbs from patients’ blood samples. An RBD-specific antibody, SAR03, was discovered that showed high binding (ELISA and SPR) and neutralizing activity (competitive ELISA and pseudovirus-based reporter assay) against Sars-CoV-2. Mechanistic studies on human cells revealed that SAR03 competes with the ACE-2 receptor for binding with the RBD domain (S1 subunit) present in the spike protein of Sars-CoV-2. This study highlights the potential of the single B cell cloning method for the rapid and efficient screening of high-affinity and effective neutralizing antibodies for Sars-CoV-2 and other emerging infectious diseases.
</div>
<div class="article-link article- html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.03.20.485024v1" target="_blank">A Novel High-Throughput Single B-Cell Cloning Platform for Isolation and Characterization of High-Affinity and potent SARS-CoV-2 Neutralizing Antibodies</a>
</div></li>
<li><strong>Validity of reported post-acute health outcomes in children with SARS-CoV-2 infection: a systematic review</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Importance: There is concern that post-acute SARS-CoV-2 infection health outcomes (“post-COVID syndrome”) in children could be a serious problem but at the same time there is concern about the validity of reported associations between infection and long-term outcomes. Objective: To systematically assess the validity of reported post-acute SARS- CoV-2 infection health outcomes in children. Evidence Review: A search on PubMed and Web of Science was conducted to identify studies published up to January 22, 2022, that reported on post-acute SARS-CoV-2 infection health outcomes in children (&lt;18 years) with a minimum follow-up of 2 months since detection of infection or 1 month since recovery from acute illness. We assessed the consideration of confounding bias and causality, and the risk of bias. Findings: 21 studies including 81,896 children reported up to 97 symptoms with follow-up periods of 2-11.5 months. Fifteen studies had no control group. The reported proportion of children with post-COVID syndrome was between 0% and 66.5% in children with SARS-CoV-2 infection (n=16,986) and 2% to 53.3% in children without SARS-CoV-2 infection (n=64,910). Only 2 studies made a clear causal interpretation of an association of SARS-CoV-2 infection and the main outcome of “post- COVID syndrome” and provided recommendations regarding prevention measures. Two studies mentioned potential limitations in the conclusion of the main text but none of the 21 studies mentioned any limitations in the abstract nor made a clear statement for cautious interpretation. The validity of all 21 studies was seriously limited due to an overall critical risk of bias (critical risk for confounding bias [n=21]; serious or critical risk for selection bias [n=19]; serious risk for misclassification bias [n=3], for bias due to missing data [n=14] and for outcome measurement [n=12]; and critical risk for selective reporting bias [n=16]). Conclusions and Relevance: The validity of reported post-acute SARS-CoV-2 infection health outcomes in children is critically limited. None of the studies provided evidence with reasonable certainty on whether SARS-CoV-2 infection has an impact on post-acute health outcomes, let alone to what extent. Children and their families urgently need much more reliable and methodologically robust evidence to address their concerns and improve care.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.18.22272582v1" target="_blank">Validity of reported post-acute health outcomes in children with SARS-CoV-2 infection: a systematic review</a>
</div></li>
<li><strong>Evaluation of a throat spray with lactobacilli in COVID-19 outpatients in a randomized, double-blind, placebo- controlled trial for symptom and viral load reduction</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives: Primary care urgently needs treatments for COVID-19 patients because current options are limited, while these patients account for more than 90% of the people infected with SARS-CoV-2. Methods: We evaluated a throat spray containing three Lactobacillaceae strains with broad antiviral properties in a randomized double-blind placebo- controlled trial. Seventy-eight eligible COVID-19 patients were randomized to verum (n=41) and placebo (n=37) within 96 hours of positive PCR-based SARS-CoV-2 diagnosis and per-protocol analysis was performed. Symptoms and severity were reported daily via an online diary. Combined nose-throat swabs and dried blood spots were collected at regular time points in the study. Results: The daily reported symptoms were highly variable, with no added benefit for symptom resolution in the verum group. Specific monitoring of the applied lactobacilli strains showed that they were detectable via microbiome (27%) and qPCR analysis (82%) of the verum group. Their relative abundances were also negatively correlated with the acute symptom score. At the end of the trial, a trend towards lower SARS-CoV-2 viral loads was observed for the verum group (2/30, 6.7% positive) compared to the placebo group (7/27, 26% positive) (p = 0.07). Conclusions: Despite a trend towards lower SARS-CoV-2 viral loads at the end of the trial and a negative correlation between relative abundances of the applied lactobacilli in the microbiome and acute symptoms, we did not observe a significant effect on overall symptom score for the verum group. This suggests that studies with earlier application of the spray in larger study populations are needed to further assess application potential.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272401v1" target="_blank">Evaluation of a throat spray with lactobacilli in COVID-19 outpatients in a randomized, double-blind, placebo-controlled trial for symptom and viral load reduction</a>
</div></li>
<li><strong>Maternal Antibody Response and Transplacental Transfer Following SARS-CoV-2 Infection or Vaccination in Pregnancy</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Pregnant persons are at increased risk of severe COVID-19 and adverse obstetric outcomes. Understanding maternal antibody response and transplacental transfer after SARS-CoV-2 infection and COVID-19 vaccination is important to inform public health recommendations. Methods: This prospective observational cohort study included 351 birthing individuals who had SARS-CoV-2 infection or COVID-19 vaccination during pregnancy. IgG and IgM to SARS-CoV-2 S1 receptor binding domain were measured in maternal and cord blood. Antibody levels and transplacental transfer ratios were compared across 1) disease severity for those with SARS-CoV-2 infection and 2) infection versus vaccination. Findings: There were 252 individuals with SARS-CoV-2 infection and 99 who received COVID-19 vaccination during pregnancy. Birthing people with more severe SARS-CoV-2 infection category had higher maternal and cord blood IgG levels (p=0.0001, p=0.0001). Median IgG transfer ratio was 0.87-1.2. Maternal and cord blood IgG were higher after vaccination than infection (p=0.001, p=0.001). Transfer ratio was higher after 90 days in the vaccinated group (p&lt;0.001). Modeling showed higher amplitude and half-life of maternal IgG following vaccination (p&lt;0.0001). There were no significant differences by fetal sex. Interpretation: COVID-19 vaccination in pregnancy leads to higher and longer lasting maternal IgG levels, higher cord blood IgG, and higher transfer ratio after 90 days compared to SARS- CoV-2 infection. Greater infection severity leads to higher maternal and cord blood antibodies. Maternal IgG decreases over time following both vaccination and infection, reinforcing the importance of vaccination, even after infection, and vaccine boosters for pregnant patients.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272574v1" target="_blank">Maternal Antibody Response and Transplacental Transfer Following SARS-CoV-2 Infection or Vaccination in Pregnancy</a>
</div></li>
<li><strong>Variation in Racial and Ethnic Representation of Heart Transplant Recipients, Waitlists, and Local Census Demographics Across Transplant Centers in the US</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
As the uses and needs for heart transplants around the world continue to rise, it is vital to investigate how the recent boom in demand comparative to availability affects racial and ethnic groups, especially in the representation in heart transplant waitlists and recipients. Here, comparisons between the racial/ethnic representation in heart transplant waitlists and recipients at heart transplant centers through the Scientific Registry for Transplant Recipients (SRTR) are drawn, comparative to the racial/ethnic representation in the location that these centers are located. Findings point towards the overrepresentation of White individuals in both waitlists and recipients, and underrepresentation in all other ethnic minorities –except African Americans– in waitlists and recipients comparative to their demographic representation in the location of the centers. This difference in representation is largest for Hispanics/Latinos and those that the SRTR classify as Other. Though just a snapshot of representation between 07/01/2019 and 06/30/2020, this may point to various systemic issues in the accessibility of care of minorities, especially during the COVID-19 pandemic, that need to be addressed as the general populous ages and heart transplants are increasingly relied upon as a treatment for cardiovascular conditions and failure.
</p>
</div>
<div class="article-link article-html- link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.15.22272420v1" target="_blank">Variation in Racial and Ethnic Representation of Heart Transplant Recipients, Waitlists, and Local Census Demographics Across Transplant Centers in the US</a>
</div></li>
<li><strong>An investigation into the wellbeing of optometry students.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Introduction: Wellbeing is synonymous with positive mental health and impacts the efficacy of student learning. The wellbeing of optometry students is an understudied topic. The wellbeing of optometry students studying in a blended undergraduate course during the COVID-19 pandemic was also unknown. The aim of this study was to determine the status of optometry students wellbeing during COVID-19, by identifying their experiences of symptoms of anxiety and depression. Moreover, to determine to what extent students experience these symptoms and what specific factors influenced their wellbeing. Methodology: Participants from four year groups completed online questionnaires. The response rate was 78.38% (n=87). Zung self-rating depression and anxiety scale questionnaires were used to determine whether students identified with a given list of symptoms commonly linked to anxiety or depression. Through open ended questions students wellbeing was further investigated. Results: Participants experienced normal levels of anxiety symptoms and most participants experienced mild to moderate depression symptoms. Of concern is the severe depression symptoms identified in the third and fourth year student cohorts. Mental health, Academics, Lifestyle, Relationships and Sleep were main themes identified that had an influence on the students general wellbeing. Uncertainty and Physical Health themes were additional influences of wellbeing specifically related to COVID-19. Contribution: This preliminary study into wellbeing of optometry students was undertaken in a unique timeframe, due to the COVID-19 pandemic. The results provide a platform to determine baseline wellbeing in the future student cohorts and the exploratory identification of factors causing stress and anxiety. The impact of COVID-19 on the wellbeing of students is evident. Conclusion: Optometry students do experience symptoms of depression. COVID-19 has had considerable impact on their academic experience and their wellbeing. Keywords: COVID-19; student wellbeing; optometry students; anxiety; depression
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272543v1" target="_blank">An investigation into the wellbeing of optometry students.</a>
</div></li>
<li><strong>A SARS-CoV-2 negative antigen rapid diagnostic in RT-qPCR positive samples correlates with a low likelihood of infectious viruses in the nasopharynx.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
SARS-CoV-2 transmission occurs even among fully vaccinated individuals; thus, prompt identification of infected patients is central to control viral circulation. Antigen rapid diagnostic tests (Ag-RDT) are highly specific, but sensitivity is variable. Discordant RT- qPCR vs Ag-RDT results are reported, raising the question of whether negative Ag-RDT in positive RT-qPCR samples could imply the absence of infectious viruses. To study the relationship between a negative Ag-RDT results with virological, molecular, and serological parameters, we selected a cross sectional and a follow-up dataset and analyzed virus culture, subgenomic RNA quantification, and sequencing to determine infectious viruses and mutations. We demonstrated that a positive SARS-CoV-2 Ag-RDT result correlates with the presence of infectious virus in nasopharyngeal samples. A decrease in sgRNA detection together with an expected increase in detectable anti-S and anti-N IgGs was verified in negative Ag-RDT / positive RT-qPCR samples. The data clearly demonstrates the less likelihood of a negative Ag-RDT sample to harbor infectious SARS-CoV-2 and consequently with a lower transmissible potential.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272008v1" target="_blank">A SARS-CoV-2 negative antigen rapid diagnostic in RT-qPCR positive samples correlates with a low likelihood of infectious viruses in the nasopharynx.</a>
</div></li>
<li><strong>An observational study of uptake and adoption of the NHS App in England</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objectives: This study aimed to evaluate patterns of uptake and adoption of the NHS App. Data metrics from the NHS App were used to assess acceptability by looking at total app downloads, registrations, appointment bookings, GP health records viewed, and prescriptions ordered. The impact of the UK COVID-19 lockdown and introduction of the COVID Pass were also explored to assess App usage and uptake. Methods: Descriptive statistics and an interrupted time series analysis were used to look at monthly NHS App metrics at a GP practice level from January 2019-May 2021 in the population of England. Interrupted time series models were used to identify changes in level and trend among App usage and the different functionalities before and after the first COVID-19 lockdown. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines were used for reporting and analysis. Results: Between January 2019 and May 2021, there were a total of 8,524,882 NHS App downloads and 4,449,869 registrations. There was a 4-fold increase in app downloads from April 2021 (650,558 downloads) to May 2021 (2,668,535 downloads) when the COVID Pass feature was introduced. Areas with the highest number of App registrations proportional to the GP patient population occurred in Hampshire, Southampton and Isle of Wight CCG, and the lowest in Blackburn with Darwen CCG. After the announcement of the first lockdown (March 2020), a positive and significant trend in the number of login sessions was observed at 602,124 (p=0.004)** logins a month. National NHS App appointment bookings ranged from 298 to 42,664 bookings per month during the study period. The number of GP health records viewed increased by an average of 371,656 (p=0.001)** views per month and the number of prescriptions ordered increased by an average of 19934 (p&lt;0.001)*** prescriptions per month following the first lockdown. Conclusion: This analysis has shown that uptake and adoption of the NHS App was positive post lockdown, and increased significantly due to the COVID Pass feature being introduced, but further research is needed to measure the extent to which it improves patient experience and influences health service access and care outcomes.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272200v1" target="_blank">An observational study of uptake and adoption of the NHS App in England</a>
</div></li>
<li><strong>ENTREPRENEURIAL ECOSYSTEMS: RECYCLING GLOVES DURING COVID-19</strong> -
<div>
The COVID-19 crisis has set we all before another novel dispute for reusing/recycling. The demand to comprise the contamination and, consequently, to stay away from however much as potential be expected to contact with possibly tainted surfaces has importantly extended the disseminate of single-use gloves, utilized most importantly in the clinical and expert field. In this study, analyzed the recycle of hand gloves for the purpose of reuse in daily life as well as collecting the gloves producing resale. The methods applied in our study achievable to disinfect the virus such as COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/8nqxt/" target="_blank">ENTREPRENEURIAL ECOSYSTEMS: RECYCLING GLOVES DURING COVID-19</a>
</div></li>
<li><strong>Exploring Trauma Responsive Educational Practices in a Museum</strong> -
<div>
Trauma infiltrates all of society – including museums. For guests, the trauma may lie in the context of the visit or what they bring with them from their everyday lives. Staff can develop trauma through daily interaction with stressful content or secondary trauma through interaction with traumatized guests. During the COVID19 pandemic, trauma also developed from workplace issues regarding personal health safety and job security. This is a case study about how one museum educated itself about the presence and impact of trauma through exploration of a framework developed by the Trauma Responsive Educational Practices (TREP) Project. We present results of a staff-wide evaluation around initial implementation of the framework. Results show staff found the framework to be relevant and useful, but they need more support adapting it to the unique environment of museums. It also triggered memories of personal trauma in some staff, requiring a rethinking about how to implement it.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/2tyu6/" target="_blank">Exploring Trauma Responsive Educational Practices in a Museum</a>
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<li><strong>Omicron Spread in Vaccinated Jurisdictions: a Statistical Study</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A correlation hypothesis between the level of vaccination and the rate of spread of the new Covid-19 variant is investigated based on the case and vaccination data from European and North American jurisdictions available in the public domain at the time point of past the crest of the Omicron wave in most jurisdictions. Statistical variables describing the rate of the spread based on observed new case statistics defined and discussed. An unexpected moderate positive correlation between the rate of the variant spread measured by two related parameters and vaccination level based on the dataset in the study is reported. While negative correlation was not statistically excluded, the analysis of the data in the study statistically excluded a moderate to strong negative correlation. The results of this work, if confirmed by further independent studies can have implications for development of policies aimed at controlling future course of the Covid-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.15.22272430v1" target="_blank">Omicron Spread in Vaccinated Jurisdictions: a Statistical Study</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Bronchipret on Antiviral Immune Response in Patients With Mild COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Bronchipret<br/><b>Sponsors</b>:   Dr. Frank Behrens;   Bionorica SE<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating Public Health Interventions to Improve COVID-19 Testing Among Underserved Populations</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Behavioral: Public Health Intervention Package<br/><b>Sponsors</b>:   Kathleen Fairfield;   MaineHealth<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Serologic Strategies for Skilled Nursing Facilities</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Cohorting<br/><b>Sponsors</b>:   NYU Langone Health;   Brown University;   National Institute on Aging (NIA)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety, Tolerability and Immunogenicity of Recombinant COVID-19 Vaccine Betuvax-CoV-2</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Betuvax-CoV-2;   Drug: Placebo<br/><b>Sponsors</b>:   Human Stem Cell Institute, Russia;   Betuvax LLC;   CEG BIO LLC<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Community-based Study of Spikogen®, a Protein-subunit Covid-19 Vaccine</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Advax-CpG55.2 adjuvanted recombinant spike protein<br/><b>Sponsors</b>:   Professor Nikolai Petrovsky;   Australian Respiratory and Sleep Medicine Institute;   Tasmanian Eye Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Volumetric Quantification on Computer Tomography Using Computer Aided Diagnostics</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Diagnostic Test: CAD analysis<br/><b>Sponsors</b>:  <br/>
Bogdan Bercean;   Pius Brinzeu Timisoara County Emergency Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults</strong> - <b>Condition</b>:   Post COVID-19<br/><b>Intervention</b>:   Other: Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults<br/><b>Sponsor</b>:   Istanbul Arel University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Early High-Titre Convalescent Plasma in Clinically Vulnerable Individuals With Mild COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVID-19 convalescent and vaccinated plasma;   Other: Current standard of care<br/><b>Sponsors</b>:   Centre Hospitalier Universitaire de Besancon;   Deutsches Rotes Kreuz DRK-Blutspendedienst Baden-Wurttemberg-Hessen;   NHS Blood and Transplant<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Variant Immunologic Landscape Trial (COVAIL Trial)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: mRNA-1273;   Biological: mRNA-1273.351;   Other: Sodium Chloride, 0.9%<br/><b>Sponsor</b>:   National Institute of Allergy and Infectious Diseases (NIAID)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of TCM Capsules Lian Hua Qing Wen Jiao Nang in Mild COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Other: TCM intervention;   Other: Placebo intervention<br/><b>Sponsor</b>:   Singapore Chung Hwa Medical Institution<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trial to Study the Efficacy and Safety of BEJO Red Ginger in COVID-19 Patients With Mild Symptoms</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: BEJO Red Ginger Extract;   Other: Placebo<br/><b>Sponsors</b>:   Research Center for Chemistry, National Research and Innovation Agency of Indonesia;   National Research and Innovation Agency of Indonesia;   RSDC Wisma Atlet;   PT. Bintang Toedjoe<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Pharmacokinetics of FBR-002 for the Treatment of Patients Hospitalized With COVID-19 in Need of Supplemental Oxygen and at Risk of Severe Outcome</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: FBR-002;   Drug: Placebo<br/><b>Sponsor</b>:  <br/>
Fab’entech<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">**Safety and Immune Response of Adjuvanted SARS-CoV-2 (COVID-19) Beta Variant RBD Recombinant Protein (DoCo-Pro-RBD-1</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">MF59®) and mRNA (MIPSCo-mRNA-RBD-1) Vaccines in Healthy Adults** - <b>Condition</b>:   SARS-CoV-2<br/><b>Interventions</b>:   Biological: Adjuvanted SARS-CoV-2 beta variant RBD recombinant protein vaccine (DoCo-Pro-RBD-1 + MF59);   Biological: SARS-CoV-2 beta variant RBD mRNA vaccine;   Other: Normal Saline<br/><b>Sponsors</b>:   University of Melbourne;   Southern Star Research<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PROSPECTIVE OPEN LABEL CLINICAL TRIAL TO ADMINISTER A BOOSTER DOSE OF PFIZER/BIONTECH OR MODERNA COVID-19 VACCINE IN HIGH-RISK INDIVIDUALS</strong> - <b>Conditions</b>:   SARS CoV 2 Infection;   COVID-19<br/><b>Interventions</b>:  <br/>
Biological: Pfizer/BioNTech (BNT162b2);   Biological: Moderna<br/><b>Sponsor</b>:  <br/>
DHR Health Institute for Research and Development<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Self-Management Interventions for Long-COVID</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Education and Strategies Intervention;   Behavioral: Mindfulness Skills Intervention<br/><b>Sponsors</b>:   Toronto Rehabilitation Institute;   Canadian Institutes of Health Research (CIHR);   University Health Network, Toronto<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Quercetin potential effects against SARS-CoV-2 infection and COVID-19-associated cancer progression by inhibiting mTOR and hypoxia-inducible factor-1alpha (HIF-1alpha)</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Long-term evolution of humoral immune response after SARS-CoV-2 infection</strong> - CONCLUSION: A steady decline in the anti-N IgG response was observed during the first year following SARS-CoV-2 infection among HCWs, whereas the anti-RBD IgG and the anti-S IgA responses remained stable and could be enhanced by COVID-19 vaccination.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Effects of Increased Glucose Level and the Role of Glycolysis on SARS CoV-2 Infection</strong> - Covid-19 has entered our lives for a long time as an infection with high mortality rates. Although the vaccination process has provided benefits, the death toll remains to be frightening worldwide. Therefore, drugs and combined therapies that can be used against Covid-19 infection are still being investigated. Most of these antiviral medications are investigational drug candidates which are still in clinical trials. In this context, holistic and different approaches for the treatment of Covid-19…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Open Reading Frame-3a gene of the 2019 novel coronavirus inhibits the occurrence and development of colorectal cancer</strong> - Intestinal microecology is composed of bacteria, fungi and viruses. As a part of intestinal microecology, viruses participate in the occurrence and development of colorectal cancer. The 2019-nCoV was detected in stool samples from patients during COVID-19, suggesting that the 2019-nCoV may be associated with intestinal microecology. However, the relationship of the 2019-nCoV and CRC is unclear. The aim of this study is to explore the role of Open Reading Frame-3a (ORF3a) of the 2019-nCoV in CRC….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neutralisation sensitivity of the SARS-CoV-2 omicron (B.1.1.529) variant: a cross-sectional study</strong> - BACKGROUND: The SARS-CoV-2 omicron (B.1.1.529) variant, which was first identified in November, 2021, spread rapidly in many countries, with a spike protein highly diverged from previously known variants, and raised concerns that this variant might evade neutralising antibody responses. We therefore aimed to characterise the sensitivity of the omicron variant to neutralisation.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity</strong> - The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a global health emergency (COVID-19) because of its rapid spread and high mortality. Since the virus epidemic, many pathogenic mechanisms have been revealed, and virus-related vaccines have been successfully developed and applied in clinical practice. However, the pandemic is still developing, and new mutations are still emerging. Virus pathogenicity is closely related to the immune status of the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Selenium in the Prevention of SARS-CoV-2 and Other Viruses</strong> - The rapid spread of new pathogens (SARS-CoV-2 virus) that negatively affect the human body has huge consequences for the global public health system and the development of the global economy. Appropriate implementation of new safety regulations will improve the functioning of the current model supervising the inhibition of the spread of COVID-19 disease. Compliance with all these standards will have a key impact on the health behavior of individual social groups. There have been demonstrably…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Photodynamic disinfection of SARS-CoV-2 clinical samples using a methylene blue formulation</strong> - The amplitude of the coronavirus disease 2019 (COVID-19) pandemic motivated global efforts to find therapeutics that avert severe forms of this illness. The urgency of the medical needs privileged repositioning of approved medicines. Methylene blue (MB) has been in clinical use for a century and proved especially useful as a photosensitizer for photodynamic disinfection (PDI). We describe the use of MB to photo-inactivate SARS-CoV-2 in samples collected from COVID-19 patients. One minute of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice</strong> - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are limited therapeutic options for the prevention and treatment of SARS-CoV-2 infections. We evaluated the antiviral activity of sulforaphane (SFN), the principal biologically active phytochemical derived from glucoraphanin, the naturally occurring precursor present in high concentrations in cruciferous vegetables. SFN inhibited in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Application of the SARS-CoV-2-S1 ACE-2 receptor interaction as the basis of the fully automated assay to detect neutralizing SARS-CoV-2-S1 antibodies in blood samples</strong> - A quantitative, high throughput, fully automated diagnostic method for the detection of neutralizing anti-SARS-CoV-2 antibodies was developed on the Phadia system based on the interaction of SARS-CoV-2 S1 protein and the human ACE-2 receptor. This method was compared to the current state of the art plaque reduction neutralization test (PRNT) and a high correlation between the two methods was observed. Using a large cohort of blood samples from convalescent patients and controls the method…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The role of neutralizing antibodies by sVNT after two doses of BNT162b2 mRNA vaccine in a cohort of Italian healthcare workers</strong> - CONCLUSIONS: Our findings reveal that the decrease of anti-S1 IgG levels do not correspond in parallel to a decrease of NAbs over time, which highlights the necessity of using both assays to assess vaccination effectiveness.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Soluble uric acid inhibits beta2 integrin-mediated neutrophil recruitment in innate immunity</strong> - Neutrophils are key players during host defense and sterile inflammation. Neutrophil dysfunction is a characteristic feature of the acquired immunodeficiency during kidney disease. We speculated that the impaired renal clearance of the intrinsic purine metabolite soluble uric acid (sUA) may account for neutrophil dysfunction. Indeed, hyperuricemia (HU, serum UA of 9-12 mg/dL) related or unrelated to kidney dysfunction significantly diminished neutrophil adhesion and extravasation in mice with…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells</strong> - Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. In the present study, we show that type 1 interferon (IFN-I) regulates coinhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting TIGIT expression. High-temporal-resolution mRNA profiling of IFN-I responses established the dynamic regulatory networks uncovering three temporal transcriptional…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules, as well as the virus per se, remain elusive. Here we report a role of RNA G-quadruplex (RG4) in SARS-CoV-2 infection. Combining bioinformatics, biochemical and biophysical assays, we demonstrate the presence of RG4s in both SARS-CoV-2 genome…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity</strong> - Ferulic acid, a bacterial metabolite of anthocyanins, seems likely to be a primary mediator of the health benefits associated with anthocyanin-rich diets, and has long been employed in Chinese cardiovascular medicine. In rodent studies, it has exerted wide-ranging antioxidant and anti-inflammatory effects, the molecular basis of which remains rather obscure. However, recent studies indicate that physiologically relevant concentrations of ferulic acid can boost expression of Sirt1 at mRNA and…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MACHINE LEARNING TECHNIQUE TO ANALYZE THE WORK PRESSURE OF PARAMEDICAL STAFF DURING COVID 19</strong> - Machine learning technique to analyse the work pressure of paramedical staff during covid 19 is the proposed invention that focuses on identifying the stress levels of paramedical staff. The invention focuses on analysing the level of stress that is induced on the paramedical staff especially during pandemic. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN353347401">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBD Covid 19 Protection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU353359094">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD AND SYSTEM FOR IMPLEMENTING IMPROVED GENERALIZED FUZZY PEER GROUP WITH MODIFIED TRILATERAL FILTER TO REMOVE MIXED IMPULSE AND ADAPTIVE WHITE GAUSSIAN NOISE FROM COLOR IMAGES</strong> - ABSTRACTMETHOD AND SYSTEM FOR IMPLEMENTING IMPROVED GENERALIZED FUZZY PEER GROUP WITH MODIFIED TRILATERAL FILTER TO REMOVE MIXED IMPULSE AND ADAPTIVE WHITE GAUSSIAN NOISE FROM COLOR IMAGESThe present invention provides a new approach is proposed that includes fuzzy-based approach and similarity function for filtering the mixed noise. In a peer group, the similarity function was adaptive to edge information and local noise level, which was utilized for detecting the similarity among pixels. In addition, a new filtering method Modified Trilateral Filter (MTF) with Improved Generalized Fuzzy Peer Group (IGFPG) is proposed to remove mixed impulse and Adaptive White Gaussian Noise from Color Images. The modified trilateral filter includes Kikuchi algorithm and loopy belief propagation to solve the inference issues on the basis of passing local message. In this research work, the images were collected from KODAK dataset and a few real time multimedia images like Lena were also used for testing the effectiveness of the proposed methodology. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN351884428">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A STUDY ON MENTAL HEALTH, STRESS AND ANXIETY AMONG COLLEGE STUDENTS DURING COVID-19</strong> - SARS-Cov-2 virus causes an infectious disease coronavirus(COVID-19).The Students life is made harder by COVID-19.The human reaction that happens normally to everyone through physical or emotional tension is stress. Feeling of angry, nervous and frustration caused through any thought or events leads to stress. As college closures and cancelled events, students are missing out on some of the biggest moments of their young lives as well as everyday moments like chatting with friend, participating in class and cultural programme. For students facing life changes due to the outbreak are feeling anxious, isolated and disappointed which lead them to feel all alone. We like to take the help of expert adolescent psychologist to find out the techniques to practice self-care and look after their mental health. We would like to find out whether techniques used reduce the anxiety and stress among Engineering Students. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN351884923">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A METHOD FOR THE TREATMENT OF COVID-19 INFECTIONS WITH PALMITOYLETHANOLAMIDE</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU351870997">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CONNECTING A TUTOR WITH A STUDENT</strong> - A system and a method for connecting a tutor with a student in real time. Initially, the system receives a student profile. Further, the system receives a question from the student. Furthermore, the system synthesizes the question based on a set of predefined machine learning model. Subsequently, the system determines a cohort of the students from the set of the cohort of the students. The cohort of the students is determined based on the one or more parameters related to the question. Further, the system identifies a tutor assigned to the cohort of the students. Subsequently, the system notifies the tutor in real time. Further, the system receives an acknowledgement from the tutor within a predefined time. Finally, the system connects the tutor with the student in real time when the acknowledgement is the positive acknowledgement. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN352550208">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A CENTRAL TRANSACTION AUTHENTIC SYSTEM FOR OTP VERIFICATION</strong> - The present invention relates to a central transaction authentic system (100) for OTP verification. The system (100) comprises one or more user display units (102), one or more financial units (104), an account deposit unit (106), an OTP authentication unit (108) and a service server unit (110). The central transaction authentic system (100) for OTP verification work as Anti-money laundering measure. The system (100) also helpful for minimizing rate of cybercrime. The central transaction authentic system (100) for OTP verification that can neutralize digital financial fraud. The present invention provides a central transaction authentic system (100) for OTP verification that can monitor and analyze every transaction and customer interaction across its customer base for suspicious and potentially criminal activity. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN350377210">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FORMULATIONS AND METHOD FOR PREPARATION OF HERBAL MEDICATED TRANSPARENT SOAP</strong> - ABSTRACTFORMULATIONS AND METHOD FOR PREPARATION OF HERBAL MEDICATED TRANSPARENT SOAPThe present invention provides formulations for herbal medicated transparent soaps and method of preparation of the same. Transparent soaps are prepared by saponification of mixture of non-edible oils to get the desired consistency and cleaning action. Nonvolatile alcohols and other transparency promoters are used to get good transparency and binding properties. Herbal extracts of different herbs are added to get medicated properties. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN350377796">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>POOL CAMPUS PLACEMENT INTERACTIVE APP FOR INDUSTRY ACADEMIA</strong> - In recent days students complete the studies through online and find difficult in getting placement. Since the COVID has stopped the Industries/Companies to conduct campus interview and direct recruitment throughout India. This leads to huge unemployment and companies lack in finding the correct person for their job. To overcome this issue it is proposed to develop an application where recruiters can easily conduct their recruitment process. This app integrates the student’s database and the Industry/company database. This model helps the recruiter to choose the eligible student from the huge database instead of a group of students from a particular University/college. There are many benefits like faster recruitment process, many students finding their dream job, HR process the interview from the remote location, entire process is in online, no need to travel and accommodate a place for rent. The entire process is recorded and saved as a report, this ensures 100 % genuine and no space for malpractice. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN352549250">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SOCIAL NAVIGATION SYSTEM FOR MOBILE ROBOTS IN THE EMERGENCY DEPARTMENT TECHNOLOGY</strong> - The emergency department (ED) is a safety-critical environment in which healthcare workers (HCWs) are overburdened, overworked, and have limited resources, especially during the COVID-19 pandemic. One way to address this problem is to explore the use of robots that can support clinical teams, e.g., to deliver materials or restock supplies. However, due to EDs being overcrowded, and the cognitive overload HCWs experience, robots need to understand various levels of patient acuity so they avoid disrupting care delivery. In this invention, we introduce the Safety-Critical Deep Q-Network (SafeDQN) system, a new acuity-aware navigation system for mobile robots. SafeDQN is based on two insights about care in EDs: high-acuity patients tend to have more HCWs in attendance and those HCWs tend to move more quickly. We compared SafeDQN to three classic navigation methods, and show that it generates the safest, quickest path for mobile robots when navigating in a simulated ED environment. We hope this work encourages future exploration of social robots that work in safety-critical, human-centered environments, and ultimately help to improve patient outcomes and save lives. Figure 1. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN349443355">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In a World on Fire, Stop Burning Things</strong> - The truth is new and counterintuitive: we have the technology necessary to rapidly ditch fossil fuels. - <a href="https://www.newyorker.com/news/essay/in-a-world-on-fire-stop-burning-things">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jerome Powell’s Double Message on Inflation</strong> - The Fed raised interest rates for the first time since 2018, but its chair insists the move won’t deliver a serious hit to the wider economy. - <a href="https://www.newyorker.com/news/our-columnists/jerome-powells-double-message-on-inflation">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Zelensky Invokes Pearl Harbor and 9/11 as He Pleads for More from Washington</strong> - The U.S. sent more than a billion dollars in aid in the past week. But Biden has refused Ukraine’s two biggest requests. - <a href="https://www.newyorker.com/news/daily-comment/zelensky-invokes-pearl-harbor-and-911-as-he-pleads-for-more-from-%20washington">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tessa Hadley on Building a Story from Details</strong> - The author discusses “After the Funeral,” her story from the latest issue of the magazine. - <a href="https://www.newyorker.com/books/this-week-in-fiction/tessa-hadley-03-28-22">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Giving Phife Dawg the Sound of “Forever”</strong> - Dion Liverpool, who co-produced a new posthumous album by the beloved Tribe Called Quest rapper, calls it the most challenging project he’s ever worked on. - <a href="https://www.newyorker.com/culture/culture-desk/giving-phife-dawg-the-sound-of-forever">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Vox Launches a Week-long Examination of Forgiveness in America</strong> -
<figure>
<img alt="" src="https://cdn.vox-
cdn.com/thumbor/fF4eFXy7ACnRDCUMZJ7LS6mPA6o=/491x0:5491x3750/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70651106/landing01.0.jpg"/>
<figcaption>
Amanda Northrop/Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0sEdBX">
By its very definition, forgiveness puts the burden on victims to figure out a path forward, to move on from the harm they endured. That conception of forgiveness is limiting. Over the next week, Vox is <a href="https://www.vox.com/22983102/forgiveness">publishing</a> a series of pieces exploring the theme of forgiveness: its role in society, its potential for catharsis, its challenges and limits.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lWCcXV">
Contributors to the package include <strong>Marin Cogan</strong> on finding forgiveness when you’ve been wronged by a power structure; <strong>Jerusalem Demsas</strong> on restorative justice; <strong>Sean Illing</strong>, with an episode of the <em>Vox Conversations </em>podcast featuring Johns Hopkins philosopher Lucy Allais; <strong>Jen Kirby </strong>on the Maryland Lynching Truth and Reconciliation Commission; <strong>Rachel Miller</strong> on how to forgive someone who isn’t all that sorry; and <strong>Aja Romano</strong> on why we’ve never successfully forgiven a famous person.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="td1JR7">
The goal of the series is to spark introspection, start thoughtful conversations, and make the case for the construction of a more forgiving American future.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OKpdjc">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GFm6ib">
</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The limits of forgiveness</strong> -
<figure>
<img alt="A drawing of a silhouette of a person looking out over a landscape and a sky with a few
clouds." src="https://cdn.vox-cdn.com/thumbor/lq6R5Z5x8OFa6YEgVqCf3mJgKQg=/332x0:5332x3750/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70650772/QA_05.0.jpg"/>
<figcaption>
Amanda Northrop/Vox
</figcaption></figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A philosopher on the complicated role of forgiveness in a polarized society.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ldRjrC">
<em>Part of our series on </em><a href="https://www.vox.com/e/22747143"><em>America’s struggle for forgiveness</em></a><em>.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f4dj2I">
It’s almost banal at this point to say that we live in a very polarized society, but it’s worth repeating because it’s an obstacle to solving almost every major political problem.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ODNJp5">
From voting rights to public health issues to climate change, it’s hard to move forward if half the population hates the other half. Conflict is baked into democratic politics, and this is a big country with lots of people who hold totally incompatible visions of the future. We need a political system that can manage these differences without sacrificing its basic legitimacy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lIkM7E">
This will no doubt require lots of work at the policy level. It will also require something on the individual level: namely, forgiveness, or something like it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LXpsZe">
We normally think of forgiveness as an interpersonal act, something that happens between individuals. But what does it mean to think of forgiveness as a political virtue?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="n43F1s">
I reached out to Lucy Allais, a philosopher at Johns Hopkins University, for an episode of <a href="https://podcasts.apple.com/us/podcast/vox-
conversations/id1081584611"><em>Vox Conversations</em></a>. Allais studies forgiveness and punishment, and she brings a unique life experience to these sorts of questions. She grew up in apartheid South Africa, and that country’s experience informs how she thinks about forgiveness in an explicitly political context. It goes without saying that contemporary America isn’t South Africa under the apartheid regime, but it’s a useful model for reflecting on these sorts of questions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YG8px1">
So we talked about the limits of forgiveness in a deeply polarized society, why she thinks forgiveness and accountability are compatible, why it’s important not to define people by their worst manifestations, and whether she believes a democracy can survive without forgiveness.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Dq1Zc9">
Below is an excerpt, edited for length and clarity. As always, there’s much more in the full podcast, so subscribe to <em>Vox Conversations</em> on <a href="https://apps.apple.com/us/app/vox-conversations/id1215557536">Apple Podcasts</a>, <a href="https://podcasts.google.com/search/vox%20conversations">Google Podcasts</a>, <a href="https://open.spotify.com/show/6NOJ6IkTb2GWMj1RpmtnxP">Spotify</a>, <a href="https://www.stitcher.com/show/vox-
conversations">Stitcher</a>, or wherever you listen to podcasts.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c149QK">
</p>
<hr class="p-entry-hr" id="mSoTOi"/>
<h4 id="LtjDBX">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uZVVfS">
Let’s start with your basic understanding of what it means to forgive.
</p>
<h4 id="rjRN2I">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HBLuna">
I think that forgiveness is most fundamentally a release from blame and anger. It’s an emotional change. It’s a change of heart, a change in how you feel toward someone. So we talk about anger as being appropriate or inappropriate, proportionate or disproportionate, and that means that we think there’s something about it that can be justified or unjustified.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xsh9qR">
What’s so puzzling about forgiveness is that it’s a release from warranted guilt. When I forgive you, I stop letting your action define the way I feel about you. When you’re angry with someone, you see them as the person who did this thing, you see them in a particular way.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="usBR8A">
Forgiveness involves a release from that, but what’s puzzling about it is that it’s not because you come to see that they didn’t do it or that they didn’t mean it or that it wasn’t their fault. All of those things are ways of coming to see that there’s nothing to forgive.
</p>
<div class="c-float-right">
<aside id="5AxfFe">
<q>“We need to see people as potentially better than the worst things they’ve done”</q>
</aside>
</div>
<h4 id="6h6yQX">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L8dxYI">
How do you square the desire to forgive with the imperative to punish wrongdoing? Some things really do demand punishment, right? Can we forgive and punish at the same time?
</p>
<h4 id="KSDm4c">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0k1AH5">
I actually think we can. I don’t believe these things are in tension with each other. It’s going to depend a bit on what you think punishment is and what you think justifies punishment. I don’t think that punishment needs to be vindictive vengeance or an all-out desire for annihilation and imposition of suffering or something.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Qi6WD3">
You can think of punishment as the way we condemn wrongdoing, or you can think of it as upholding the law by imposing a penalty that you announced in advance would be imposed for this kind of transgression of the law. And those things are important. We should condemn wrongdoing. I don’t think we can have justice without the rule of law.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="z81nGQ">
But I see these sorts of things as separate or potentially separable from how you feel, from having resentful feelings toward someone. So you can condemn something and impose some penalty while also having very charitable feelings toward the person.
</p>
<h4 id="Jo75Cu">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9SeDuY">
Do you think we can forgive someone who doesn’t want or accept forgiveness? Does the act still carry meaning in that case?
</p>
<h4 id="psCVsx">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ejyMrC">
Yeah, I think it does. In fact, I think you can forgive the dead, because it’s about changing your orientation to the other person, and you can do that even if they don’t want or accept it.
</p>
<div class="c-float-right c-float-hang">
<div id="vvDg7m">
<div>
</div>
</div>
</div>
<h4 id="7WF8QU">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pvN07x">
This brings us to this question of forgiveness and politics. I just have to say up front that people who listen to this show know my politics are on the left and there’s a version of this conversation that’s framed as, “How do we forgive all those Trump voters?” and I have no interest in that. It’s too simplistic and boring and would undercut the spirit of this conversation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nDCbEX">
But we are living in a very polarized society and there’s plenty of contempt to go around. We don’t normally think of forgiveness as a political virtue, for all kinds of reasons, but do you think we should?
</p>
<h4 id="Z5rrqL">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K5WIwu">
I think that not hating people is politically important. I grew up in South Africa during apartheid. Apartheid was one of the evil injustices of the 20th century. It was an atrocity, it was evil. And I grew up in white South Africa and everybody supported it, or let me say that the majority of the white electorate voted for the apartheid party.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EIHnOR">
So most of these people supported this thing and this thing that they supported was evil and deeply unjust. But were they all evil people? That’s not so obvious to me. I had a great aunt who voted for the apartheid government all her life, or at least most of her life, and she was a very warm, bubbly, affectionate Christian person who lived in a small conservative farming community. And she supported this evil for most of her life.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KMeVno">
But it’s complicated, right? You want to say that it’s not plausible that this person is not evil, and yet they’re actually supporting evil. Now, you can say that they’ve grown up in this indoctrinated system and there was all this press censorship and complete control of the education system and you can understand how this person came to hold these beliefs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jH3x99">
But on the other hand, I want to say that that’s not an excuse. Maybe you believed the propaganda, but still, you knew that the system you were supporting refused to let Black people vote, that it gave them worse schools. You knew that Black people weren’t allowed on the same beaches. You couldn’t not know that. You can make all kinds of excuses, but I don’t think it’s totally exculpatory. Someone who’s really thinking about it can see their way through that. It’s complicated when it comes to seeing people as blameworthy and that’s sort of the point.
</p>
<h4 id="ZFLXb9">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M7CYwx">
Something I’ve noticed living in a place where my politics are out of step with a lot of the people around me — I live in Gulfport, Mississippi — is that if you can find a way to engage people in ways that don’t activate their defenses, you can cut through the performative identity-signaling stuff and find common ground. That’s not necessarily about forgiveness, but it is about seeing people in three dimensions, about not judging them by what you might think is their worst manifestation.
</p>
<h4 id="4pplT4">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ThzlHR">
That’s connected to forgiveness in an interesting way. We need to see people as potentially better than the worst things they’ve done. And what I think is so important about that is that people need a way to back down. You need to give people a way to back down. If you want people to change, you have to make it possible for them to back down and then accept their backing down.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CRDoDa">
As human beings, we have a deep need to see ourselves as making sense. We need to see ourselves as basically oriented to the good. I think we all need to be seen as justified. And so when we are engaged in something that isn’t justified, we all have a very deep human tendency to rationalize and to engage in self-deception and to engage in delusional ideology that makes sense of why we are really entitled. And you don’t break through that by telling a person that they’re terrible.
</p>
<h4 id="5zy3xL">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sRE7mE">
This need to make sense of ourselves makes us extremely vulnerable to self-deception.
</p>
<h4 id="OfVEva">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zez0lc">
We need to make sense of ourselves in situations in which it isn’t fully possible to make sense of ourselves, and this makes simple narratives that give illusions of sense and entitlement appealing. It is difficult to come to terms with having been wrong or having done wrong because it can make us feel too bad about ourselves.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YFumKN">
In order to grow, and even just to act, people need to be able to integrate a sense of themselves as having done something wrong with being okay, still lovable. This is scary and takes strength.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZJJPF0">
Part of the gift of forgiveness, and what can be powerful about it, is that seeing another in this hopeful way — as having done something wrong, but still lovable, still okay — creates a space in which there is a possibility for them to face their flaws without needing defensive denial.
</p>
<h4 id="BZg2TA">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8wZcnL">
Part of the story I hear you telling about forgiveness is that, on some level, we’re all sort of ridiculous creatures, we’re all complicated and contradictory creatures, and we naturally assume the best of ourselves and the worst of our opponents, and it’s important to keep that inclination in mind.
</p>
<h4 id="BA1bl3">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MK52Em">
Absolutely. And also it’s important to remember that there are actually terrible injustices, like apartheid, but then there are lots of things where it’s not totally clear what’s right or what’s wrong. It’s complicated. And we should be careful about being too sure about our beliefs.
</p>
<h4 id="2GjZpo">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vSpl6E">
Yeah, but<strong> </strong>all of our political divisions are not the result of misunderstandings and confusion. There are truly incompatible visions of the good, of justice, and there are people who really do hate, who really do want to live in a world that I find intolerable, and these people do not want forgiveness, will not accept it, and they have to be defeated first and perhaps forgiven later.
</p>
<h4 id="SOaa2s">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lbZcsP">
That’s real, no doubt. But we all live in our own bubbles and I wonder about the differences between the absolutely cynical political actors who are leading things, the Sean Hannitys and the Mitch McConnells of the world, who really do know what’s going on, who know what they’re saying isn’t true, and the people in the base who are being told by every single source they’ve ever taken news from that, for example, there was a corrupt election. There are different layers of culpability.
</p>
<h4 id="79S07S">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bNmoo1">
The pandemic and the debate over vaccines is such an obvious example here. Our ability to deal with this virus, or at least slow it down, has been undermined by people who refused to get vaccines for all kinds of reasons, and that pisses me off and I know it pisses off lots of other people.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eHe69o">
And yet, as you were just saying, there are layers of culpability. The Tucker Carlsons or the Laura Ingrahams of the world, the people publicly sowing doubts about vaccines while almost certainly receiving them in private, are not good-faith actors. They’re television performers peddling a product.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GObpnI">
But how do we think about our neighbor or our family member who may be genuinely anxious about the vaccine, who genuinely believes it’s not safe, who’s been told it’s not safe by people they trust? I can forgive that, I can understand that, but I can’t forgive the bad-faith operators.
</p>
<h4 id="rkLdic">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tLpMFA">
I think the people who have consciously spread vaccine misinformation are in a separate moral category from the people who exist in information ecosystems that suggest to them that this is doubtful.
</p>
<div class="c-float-right">
<aside id="NpnSVL">
<q>“We need to make sense of ourselves in situations in which it isn’t fully possible to make sense of ourselves”</q>
</aside>
</div>
<h4 id="7j8Tkp">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yGK0sB">
A lot of people, with good reasons, point to social media and “cancel culture” as evidence that we’re becoming a more punitive society. I do think that the internet has made us less forgiving on the whole, and I worry that the world we’ve built has supercharged our worst pathologies. Do you think that technology is making it harder and harder for us to forgive?
</p>
<h4 id="4MeUg6">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mVLFbP">
Twitter mobs and the comments section of the internet do seem to reveal some terrifyingly punitive, uncharitable, angry, ugly parts of humans. Something about the speed with which people can respond and pile on, and sometimes anonymity, seems to encourage this, but I wonder how much of it is caused by the technology and how much is revealed by it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fK2q4f">
Perhaps it is loneliness, alienation, and a perceived lack of agency behind some of the anger and apparent desire to crush others. It does seem like anonymity encourages people to let their worst sides show, and perhaps the rapidity of the communication technology makes people less likely to think carefully before they speak.
</p>
<h4 id="5PkMNH">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Tb1agF">
We can probably assume that lots of people won’t be able to forgive fellow citizens for what they believe or what they’ve done, so can we move forward in the absence of that forgiveness?
</p>
<h4 id="JPOXat">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8eTP0B">
We can move forward without forgiveness. I think it’s very hard to move forward if you can’t get beyond hatred, however.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7A0a9s">
So you told me that you position yourself on the left, but you didn’t want to frame this as, “How can we forgive Trump voters?” and that’s fine, but let’s suppose someone out there is thinking like that. Being angry about Trump voters is just not a productive way of thinking about them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="NxJ9lH">
For one thing, you’re not actually in a relationship with these other people. And also these are complicated people who might be struggling, who might be one paycheck away from bankruptcy because of a medical emergency. Who knows what’s going on in their lives?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zGc4vo">
When I think about forgiveness, I go back to what we were saying at the very beginning: that it’s about not holding things against someone. Most fundamentally, it’s about seeing people with an openness and an optimism.
</p>
<h4 id="bMJnic">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s5gXtV">
One obvious challenge is that the onus for forgiveness necessarily falls on the victim. It’s easy to say “we should forgive,” harder to say that to a Black mother whose son has been shot by police, or a family who’s been separated by the government at the border, or a parent whose kid was killed in a mass shooting. Is it fair that the victims should shoulder that burden? Or is forgiveness, in your mind, beyond “fair” and “unfair”?
</p>
<h4 id="hfFx8f">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FBYLXa">
I do think that forgiveness is in a way beyond “fair” and “unfair.” I think it is almost intrinsic to forgiveness that it gives people something better than they deserve or have a right to.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="du8UOc">
But I don’t find it obvious that forgiveness is required for democracy to function. Some amount of reconciliation, and lack of hatred, seems good and maybe needed for democracy, but that can be achieved without forgiveness. But even reconciliation that is less than forgiveness puts burdens on those who have been historically victimized, so the more political culture and policies can do to acknowledge such victimization the better. I think we should almost always avoid telling people that they should forgive.
</p>
<h4 id="Uwrboz">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nOHVp1">
Is forgiveness something that politics or policy can ever reliably foster?
</p>
<h4 id="WS7ODm">
Lucy Allais
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GihplZ">
I think that politics and policy can potentially foster reconciliation and restitution; symbolic and material reparations, and public recognition of victims and condemnation of wrongs can play a role in this.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UsGcFO">
Finding ways of exposing people to other people’s narratives and experiences seems like it would be helpful in fostering forgiveness. But how to bring that about is not easy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FKLESk">
<em>To hear the rest of the conversation, </em><a href="https://open.spotify.com/episode/2zxessjixp0xR62HuIX8av?si=kkYDh7clSSCC5OFCDjYnhg"><em>click here</em></a><em>, and be sure to subscribe to </em>Vox Conversations<em> on </em><a href="https://apps.apple.com/us/app/vox-
conversations/id1215557536"><em>Apple Podcasts</em></a><em>, </em><a href="https://podcasts.google.com/search/vox%20conversations"><em>Google Podcasts</em></a><em>, </em><a href="https://open.spotify.com/show/6NOJ6IkTb2GWMj1RpmtnxP"><em>Spotify</em></a><em>, </em><a href="https://www.stitcher.com/show/vox-conversations"><em>Stitcher</em></a><em>, or wherever you listen to podcasts.</em>
</p>
<div>
<div id="qfhFxK">
<div>
</div>
</div>
</div>
<ul>
<li><strong>America’s struggle for forgiveness</strong> -
<figure>
<img alt="A drawing of silhouetted figures in a mountainous landscape looking at a ladder leading up
through a lit circle." src="https://cdn.vox-
cdn.com/thumbor/hs3FzC5H7gugMG420cyAlbTCg_U=/659x0:5659x3750/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70650767/landing01.0.jpg"/>
<figcaption>
Amanda Northrop/Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Vox writers examine why forgiveness is an elusive goal, and how we can all forge ahead.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Dm2zdR">
By its very definition, forgiveness puts the burden on victims to figure out a path forward, to move on from the harm they endured. That conception of forgiveness is limiting. We wanted to ask, why has America been unable to reckon with its past? What should happen after we uncover major wrongdoings, on both systemic and personal levels, as we saw with the Me Too movement? What can we do to face our faults but still forge ahead, stronger and more thoughtful than we were before?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F9vG5U">
We are living through an angry, polarized time when just broaching the idea of forgiveness might seem out of step with the zeitgeist. But it’s worth talking about forgiveness now precisely for that reason. We shouldn’t think of forgiveness as a luxury we can dispense in the best of times. It is something we should confront and consider precisely when it’s hard to do.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7e45CF">
Over the next week, we will publish several pieces on the theme of forgiveness: its role in a civilized society, its potential for catharsis, its challenges and limits. We hope they spark introspection, start thoughtful conversations, and make the case for the construction of a more forgiving American future.
</p>
<figure class="e-image">
<img alt="A Black woman sitting in her house at a
table and looking out the window." src="https://cdn.vox-
cdn.com/thumbor/zl0q2XUl3MvUkpG3jVTMIKaYOFg=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23324096/20220314_Vox_ForgivenessPackage_0178.jpg"/> <cite>Amber N. Ford for Vox</cite>
</figure>
<h3 id="yQs0BS">
<a href="https://www.vox.com/e/22747145">When justice isn’t served, how do we find forgiveness?</a>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m6o4AH">
Delores White said she was defending her daughter. She went to jail anyway.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DxuX5P">
by Marin Cogan and Madeleine O’Neill
</p>
<figure class="e-image">
<img alt="A
drawing of a silhouette of a person looking out over a landscape and a sky with a few clouds." src="https://cdn.vox-
cdn.com/thumbor/x3txpcQ7vU2EPNZ4sjq9y6EqDdM=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23316024/QA_05.jpg"/> <cite>Amanda Northrop/Vox</cite>
</figure>
<h3 id="KsUUFD">
<a href="https://www.vox.com/e/22663512">The limits of forgiveness</a>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qt6OND">
A philosopher on the complicated role of forgiveness in a polarized society.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eTfsCd">
by Sean Illing
</p>
<figure class="e-image">
<img alt="Illustration of a circle with a line through it, surrounded by arrows leading around
the circle." src="https://cdn.vox-cdn.com/thumbor/P1H572ZwfseaUnWlEk_zNEK6wp0=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23327149/cycle_final.jpg"/> <cite>Amanda Northrop/Vox</cite>
</figure>
<h3 id="vpv9C1">
<strong>Everyone wants forgiveness, but no one is being forgiven (Coming Tuesday)</strong>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Pc0cQI">
The state of modern outrage is a cycle. Could a culture of forgiveness ever break it?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ycnrfq">
by Aja Romano
</p>
<figure class="e-image">
<img alt="Illustration of two silhouetted people inside overlapping
circles, with one person holding out a hand." src="https://cdn.vox-
cdn.com/thumbor/UQNWXHRfROJY2hlbaF6AaigxxhE=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23323464/restore04.jpg"/> <cite>Amanda Northrop/Vox</cite>
</figure>
<h3 id="NxabUd">
<strong>The promise — and problem — of restorative justice (Coming Wednesday)</strong>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QvPt2v">
Who is restorative justice restoring?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tFPhjJ">
by Jerusalem Demsas
</p>
<figure class="e-image">
<pre><code> &lt;img alt=" " src="https://cdn.vox-cdn.com/thumbor/Weos-</code></pre>
W_HHcq254G8Zx3r_rKaK6s=/800x0/filters:no_upscale()/cdn.vox- cdn.com/uploads/chorus_asset/file/23325874/GettyImages_72635956.jpg" /&gt; <cite>Gianluigi Guercia/AFP via Getty Images</cite>
</figure>
<h3 id="97o9qq">
<strong>The impossible task of truth and reconciliation (Coming Thursday)</strong>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eHDKld">
Commissions are a common tool to expose atrocities after war and genocide. It is reconciliation — and forgiveness — that are harder to come by.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="868xAM">
by Jen Kirby
</p>
<figure class="e-image">
<img alt="A drawing of a person looking up at a ladder going through a lit hole." src="https://cdn.vox-cdn.com/thumbor/h7PXr_ef4yr-_o772wKw19GchTU=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23315836/ladder04.jpg"/> <cite>Amanda Northrop/Vox</cite>
</figure>
<h3 id="18XYQA">
<strong>How to forgive someone who isn’t sorry (Coming Friday)</strong>
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2Hmczc">
Some people will never admit wrongdoing. It’s still possible for you to move forward.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="enOhOg">
by Rachel Wilkerson Miller
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ahead Of My Time and It’s My Time excel</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nida Dar helps Pakistan finally break World Cup drought</strong> - West Indies managed only 89-7 in a match curtailed to 20 overs-a-side due to rain, and Pakistan surpassed that total with seven balls to spare</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hyderabad FC win maiden ISL Trophy; beat Kerala Blasters on penalty shoot-out</strong> - Hyderabad FC lift their first Hero Indian Super League trophy, thanks to goalkeeper Laxmikant Kattimani’s penalty shoot- out heroics</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Charity Cup | Praggnanandhaa stuns World No. 3 Ding Liren</strong> - Earlier in the day, Praggnanandhaa lost to Duda but more than made up by beating Canada’s Eric Hansen</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ICC Women’s World Cup | India can't afford anymore slip-ups in must-win game against Bangladesh</strong> -</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fuel transporters begin indefinite strike</strong> - Discussions to reconcile issues fail</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exert adequate pressure on Centre in Mekedatu issue, Dhinakaran tells Tamil Nadu government</strong> - ‘Do not to forego the interests of the State by relying on  strategies of the Karunanidhi era’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>22,500 Indians returned from Ukraine between February 1 and March 11: Govt</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>E-invoicing must from April 1 for businesses with annual turnover above ₹20 crore</strong> - It enables real-time tracking of invoices prepared by supplier</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Farm dept. plans new approach to boost production</strong> - Individual farms will be developed scientifically through Krishi Bhavans</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine conflict: Russian shelling blamed for corrosive gas leak</strong> - The ammonia leak has been contained but prompted a warning residents should stay indoors.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Moscow stock market reopens for some bond trading</strong> - Trading in bonds issued by the Russian government has restarted but other business remains suspended.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Six killed after car drives into crowd in Belgium</strong> - Dozens more are injured in the crash, which the mayor of the town says is a “national catastrophe”.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: ‘Tanks in streets’ as fighting hits Mariupol centre</strong> - Street fighting hampers efforts to rescue civilians trapped in a bombed theatre, the mayor says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia claims first use of hypersonic Kinzhal missile in Ukraine</strong> - Russia says it fired a Kinzhal missile at a Ukrainian arms depot, in an apparent change of strategy.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Samsung Galaxy S22 Ultra review: The slab phone retirement plan</strong> - Samsung stands still while the competition is better than ever. - <a href="https://arstechnica.com/?p=1837694">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The TikTok-Oracle deal would set two dangerous precedents</strong> - The agreement may provoke a global data storage melee. - <a href="https://arstechnica.com/?p=1842172">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A big bet to kill the password for good</strong> - FIDO Alliance says it’s found the missing piece on the path to a password-free future. - <a href="https://arstechnica.com/?p=1842190">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The weekend’s best deals: Apple Watch Series 7, gift card bundles, and more</strong> - Dealmaster also has a big PC games charity bundle, Anker chargers, and the Xbox Series S. - <a href="https://arstechnica.com/?p=1842255">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How did a vast Amazon warehouse change life in a former mining town?</strong> - Looking back a decade after the mine closed and Amazon opened up. - <a href="https://arstechnica.com/?p=1842277">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A naked man was walking down the street with a woman on his back</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A gentleman on the other side of the road asked, “Where are you going?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The naked man replied, “To a fancy dress party.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“What as?” asked the bemused gentleman.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“A tortoise”, said the naked man.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Well, who is the woman on your back?” said the intrigued gentleman.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Oh, that’s Michelle.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/-Hal-Jordan-"> /u/-Hal-Jordan- </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/tj4lox/a_naked_man_was_walking_down_the_street_with_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/tj4lox/a_naked_man_was_walking_down_the_street_with_a/">[comments]</a></span></p></li>
<li><strong>My girlfriend is so smart, she really surprises me!</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I went golfing, and forgot to bring my phone, so I used my friend’s phone to call her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She answered: “What’s up, honey?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
What a smart girl! She knew I was the one on the phone!
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/tj73wu/my_girlfriend_is_so_smart_she_really_surprises_me/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/tj73wu/my_girlfriend_is_so_smart_she_really_surprises_me/">[comments]</a></span></p></li>
<li><strong>My wife is brilliant. She never says no to a shag, has great tits and even swallows.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
But her bird collecting has gone far enough now.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Wanan1"> /u/Wanan1 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/tis3h6/my_wife_is_brilliant_she_never_says_no_to_a_shag/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/tis3h6/my_wife_is_brilliant_she_never_says_no_to_a_shag/">[comments]</a></span></p></li>
<li><strong>In Britain they call it a “lift” but Americans call it an “elevator”</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I guess we’re just raised differently
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/SansTheMinion"> /u/SansTheMinion </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/tj0pwz/in_britain_they_call_it_a_lift_but_americans_call/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/tj0pwz/in_britain_they_call_it_a_lift_but_americans_call/">[comments]</a></span></p></li>
<li><strong>A programmer and his project manager board a train headed through the mountains. They can find no other place to sit, except for two seats right across the aisle from a young woman and her grandmother.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
After a while, it becomes quite clear that the woman and the programmer are interested in each other, as they keep looking at each other.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Soon, the train passes into a tunnel and it is pitch black. There is the sound of a kiss followed by the sound of a slap.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
When the train finally emerges from the tunnel, the four sit there without saying a word.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The grandmother thinks to herself, “It was very rude of that young man to kiss my granddaughter, but I am glad she slapped him.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The project manager thinks to himself, “I did not think the programmer was brave enough to kiss the woman, but I wish she hadn’t missed him when she slapped me.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The young woman thought to herself, “I am glad the guy kissed me, but I wish my grandmother had not slapped him.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The programmer has a satisfied smile on his face and thinks, “Life is good. How often does a guy have a chance to kiss a beautiful woman and slap his project manager at the same time.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Lava_Wolf_68"> /u/Lava_Wolf_68 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/tio1bn/a_programmer_and_his_project_manager_board_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/tio1bn/a_programmer_and_his_project_manager_board_a/">[comments]</a></span></p></li>
</ul>
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