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+ + + ++The Delta SARS-CoV-2 variant has spread quickly since first being identified. To better understand its epidemiological characteristics and impact, we utilize multiple datasets and comprehensive model-inference methods to reconstruct COVID-19 pandemic dynamics in India, where Delta first emerged. Using model-inference estimates from March 2020 to May 2021, we estimate the Delta variant can escape adaptive immunity induced by prior wildtype infection roughly half of the time and is around 60% more infectious than wildtype SARS-CoV-2. In addition, our analysis suggests that the recent case decline in India was likely due to implemented non-pharmaceutical interventions and weather conditions less conducive for SARS-CoV-2 transmission during March - May, rather than high population immunity. Model projections show infections could resurge as India enters its monsoon season, beginning June, if intervention measures are lifted prematurely. +
++Importance: While COVID-19 vaccines are highly effective against disease, breakthrough infections may occur in the context of rising variants of concern. Objective: We paired random and passive surveillance nucleic acid testing with analysis of viral whole genomic sequences to detect and describe breakthrough infections, focusing in a university community. Design: Anterior nasal swabs were collected from individuals for a nucleic acid amplification test (NAAT) for detection of SARS-CoV-2. A subset of NAAT positive samples was sequenced to determine variants associated with infections. Included in the testing and sequencing protocol were individuals that were fully vaccinated. Setting: This study was performed as part of a surveillance program for SARS-CoV-2 on a university campus with 49,700 students and employees. Participants: Surveillance testing was random and included approximately 10% of the population each week. Additionally, individuals self-identified with COVID-19 related symptoms or those that had close contact with SARS-CoV-2 positive individuals were also tested. +
++Digital contact tracing applications have been introduced in many countries to aid in the containment of COVID-19 outbreaks. Initially, enthusiasm was high regarding their implementation as a non-pharmaceutical intervention (NPI). Yet, no country was able to prevent larger outbreaks without falling back to harsher NPIs, and the total effect of digital contact tracing remains elusive. Based on the results of empirical studies and modeling efforts, we show that digital contact tracing apps might have prevented cases on the order of single-digit percentages up until now, at best. We show that this poor impact can be attributed to a combination of low participation rates, a non-flexible reliance on symptom-based testing, low engagement of participants, and delays between testing and test result upload. We find that contact tracing does not change the epidemic threshold and exclusively prevents more cases during the supercritical phase of an epidemic, making it unfit as a tool to prevent outbreaks. Locally clustered contact structures may increase the intervention9s efficacy, but only if the number of contacts per individual is homogeneously distributed, a condition usually not found in contact networks. Our results suggest that policy makers cannot rely on digital contact tracing to contain outbreaks of COVID-19 or similar diseases. +
++The impact of long COVID is increasingly recognised, but risk factors are poorly characterised. We analysed questionnaire data on symptom duration from 10 longitudinal study (LS) samples and electronic healthcare records (EHR) to investigate sociodemographic and health risk factors associated with long COVID, as part of the UK National Core Study for Longitudinal Health and Wellbeing. Methods Analysis was conducted on 6,899 adults self-reporting COVID-19 from 45,096 participants of the UK LS, and on 3,327 cases assigned a long COVID code in primary care EHR out of 1,199,812 adults diagnosed with acute COVID-19. In LS, we derived two outcomes: symptoms lasting 4+ weeks and symptoms lasting 12+ weeks. Associations of potential risk factors (age, sex, ethnicity, socioeconomic factors, smoking, general and mental health, overweight/obesity, diabetes, hypertension, hypercholesterolaemia, and asthma) with these two outcomes were assessed, using logistic regression, with meta-analyses of findings presented alongside equivalent results from EHR analyses. Results Functionally limiting long COVID for 12+ weeks affected between 1.2% (age 20), and 4.8% (age 63) of people reporting COVID-19 in LS. The proportion reporting symptoms overall for 12+ weeks ranged from 7.8 (mean age 28) to 17% (mean age 58) and for 4+ weeks 4.2% (age 20) to 33.1% (age 56). Age was associated with a linear increase in long COVID between age 20-70. Being female (LS: OR=1.49; 95%CI:1.24-1.79; EHR: OR=1.51 [1.41-1.61]), poor pre-pandemic mental health (LS: OR=1.46 [1.17-1.83]; EHR: OR=1.57 [1.47-1.68]) and poor general health (LS: OR=1.62 [1.25-2.09]; EHR: OR=1.26; [1.18-1.35]) were associated with higher risk of long COVID. Individuals with asthma also had higher risk (LS: OR=1.32 [1.07-1.62]; EHR: OR=1.56 [1.46-1.67]), as did those categorised as overweight or obese (LS: OR=1.25 [1.01-1.55]; EHR: OR=1.31 [1.21-1.42]) though associations for symptoms lasting 12+ weeks were less pronounced. Non-white ethnic minority groups had lower 4+ week symptom risk (LS: OR=0.32 [0.22-0.47]), a finding consistent in EHR. Associations were not observed for other risk factors. Few participants in the studies had been admitted to hospital (0.8-5.2%). Conclusions Long COVID is clearly distributed differentially according to several sociodemographic and pre-existing health factors. Establishing which of these risk factors are causal and predisposing is necessary to further inform strategies for preventing and treating long COVID. +
++A wastewater surveillance program targeting a university residence hall was implemented during the spring semester 2021 as a proactive measure to avoid an outbreak of COVID-19 on campus. Over a period of 7 weeks from early February through late March 2021, wastewater originating from the residence hall was collected as grab samples 3 times per week. During this time, there was no detection of SARS-CoV-2 by RT-qPCR in the residence hall wastewater stream. Aiming to obtain a sample more representative of the residence hall community, a decision was made to use passive samplers beginning in late March onwards. Adopting a Moore Swab approach, SARS-CoV-2 was detected in wastewater samples on just two days after passive samplers were activated. These samples were also positive for the B.1.1.7 (Alpha) Variant of Concern (VOC) by RT-qPCR. The positive result triggered a public health case finding response including a mobile testing unit deployed to the residence hall the following day with testing of nearly 200 students and staff, which identified two laboratory-confirmed cases of B.1.1.7 variant COVID-19. These individuals were re-located to a separate quarantine facility averting an outbreak on campus. Aggregating wastewater and clinical data, the campus wastewater surveillance program has yielded the first estimates of fecal shedding rates of the B.1.1.7 VOC of SARS-CoV-2 in individuals from a non-clinical setting. +
++Objective: To perform a systematic and meta-analysis on the prevalence rates of mental health symptoms including anxiety and depression during the COVID-19 pandemic in the general population in Eastern Europe, as well as three select sub-populations: students, general healthcare workers, and frontline healthcare workers. Data sources: Studies in PubMed, Embase, Web of Science, Psycinfo, and medRxiv up to February 6, 2021. Eligibility criteria and data analysis: Prevalence rates of mental health symptoms in the general population and key sub-populations during the COVID-19 pandemic in Eastern Europe. Data were pooled using a random-effects meta-analysis to estimate the prevalence rates of anxiety and depression. Results: The meta-analysis identifies and includes 21 studies and 26 independent samples in Eastern Europe. Poland (n=4), Serbia (n=4), Russia (n=3), and Croatia (n=3) had the greatest number of studies. To our knowledge, no studies have been conducted in eleven Eastern European countries including Hungary, Slovakia, and Slovenia. The pooled prevalence of anxiety in 18 studies with 22 samples was 30% (95% CI: 24%-37%) and pooled prevalence of depression in 18 studies with 23 samples was 27% (95% CI: 21%-34%). Implications: The cumulative evidence from the meta-analysis reveals high prevalence rates of clinically significant symptoms during the COVID-19 pandemic in Eastern Europe. The findings suggest evidence of a potential mental health crisis in Eastern Europe during the ongoing COVID-19 pandemic. Our synthesis also reveals a relative lack of studies in certain Eastern European countries as well as high heterogeneities among the existing studies, calling for more effort to achieve evidence-based mental healthcare in Eastern Europe. Keywords: COVID-19; Epidemic; General Population; Healthcare Workers; Frontline Healthcare Workers; Psychiatry Highlights: The pooled prevalence of anxiety and depression were 30% and 27% in Eastern Europe, respectively. +
++The coronavirus disease is spreading continuously worldwide with an unprecedented amount of impact on every human society. In order to reduce the risks of infections and mortality, several interventions such as mobility restrictions for different age groups and vaccination prioritization programs are implemented in the Philippines. Identifying age-sex composition with greater susceptibility, longer hospitalization, and higher fatality is useful to guide the targeted intervention and establish risk stratification for patients infected with COVID-19 within communities and localities. Furthermore, it is also helpful in the allocation of medical resources and assessment of vaccination priority. We analyzed the COVID-19 data provided by the Davao Center for Health Development of the Department of Health Davao Region in the Philippines. The dataset contains records of COVID-19 cases reported from March 2020 to April 2021. Methods that were used include descriptive statistics, graphical presentations, and nonparametric statistical methods. The study reveals that male children and female senior citizens are the most susceptible age-sex composition while male senior citizen is the subgroup with the highest case fatality and mortality. Furthermore, regardless of sex groups, the senior citizen is the subgroup with the longest hospitalization. Susceptibility due to exposure should be included as a criterion in determining the age-sex compositions for vaccination priority against COVID-19 and other potentially deadly viruses. Further, Proper planning and allocation of medical resources for the elderly should be prioritized in the provincial levels. +
++The increasing risk from viral outbreaks such as the ongoing COVID-19 pandemic exacerbates the need for rapid, affordable and sensitive methods for virus detection, identification and quantification; however, existing methods for detecting virus particles in biological samples usually depend on multistep protocols that take considerable time to yield a result. Here, we introduce a rapid fluorescence in situ hybridization (FISH) protocol capable of detecting influenza virus, avian infectious bronchitis virus and SARS-CoV-2 specifically and quantitatively in approximately 20 minutes, in both virus cultures and combined throat and nasal swabs without previous purification. This fast and facile workflow is applicable to a wide range of enveloped viruses and can be adapted both as a lab technique and a future diagnostic tool. +
++Introduction The rapid surge of cases and insufficient numbers of intensive care unit (ICU) beds have forced hospitals to utilise their general wards for administration of non-invasive respiratory support including HFNC(High Flow Nasal Cannula) in severe COVID-19. However, there is a dearth of data on the success of such advanced levels of care outside the ICU setting. Therefore, we conducted an observational study at our centre, and systematically reviewed the literature, to assess the success of HFNC in managing severe COVID–19 cases outside the ICU. Methods A retrospective cohort study was conducted in a tertiary referral centre where records of all adult COVID–19 patients (over 18 years) requiring HFNC support were between September and December 2020 were analysed. HFNC support was adjusted to target SpO2 over 90% and respiratory rate less than 30 per min. The clinical, demographic, laboratory, and treatment details of these patients were retrieved from the medical records and entered in predesigned proforma. Outcome parameters included duration of oxygen during hospital stay, duration of HFNC therapy, length of hospital stay and death or discharge. HFNC success was denoted when a patient did not require escalation of therapy to NIV or invasive mechanical ventilation, or shifting to the ICU, and was eventually discharged from the hospital without oxygen therapy; otherwise, the outcome was denoted as HFNC failure. Systematic review was also performed on the available literature on the experience with HFNC in COVID–19 patients outside of ICU settings using the MEDLINE, Web of Science and Embase databases. Statistical analyses were performed with the use of STATA software, version 12, OpenMeta[Analyst], and visualization of the risk of bias plot using robvis. Results Thirty-one patients receiving HFNC in the ward setting, had a median age of 62 (50 – 69) years including 24 (77%) males. Twenty-one (68%) patients successfully tolerated HFNC and were subsequently discharged from the wards, while 10 (32%) patients had to be shifted to ICU for non–invasive or invasive ventilation, implying HFNC failure. Patients with HFNC failure had higher median D–dimer values at baseline (2.2 mcg/ml vs 0.6 mcg/ml, p=0.001) and lower initial SpO2 on room air at admission (70% vs 80%, p=0.026) as compared to those in whom HFNC was successful .A cut–off value of 1.7 mg/L carried a high specificity (90.5%) and moderate sensitivity (80%) for the occurrence of HFNC failure. Radiographic severity scoring as per the BRIXIA score was comparable in both the groups(11 vs 10.5 out of 18, p=0.78 ). After screening 98 articles, total of seven studies were included for synthesis in the systematic review with a total of 820 patients, with mean age of the studies ranging from 44 to 83 years and including 62% males. After excluding 2 studies from the analysis, the pooled rates of HFNC failure were 36.3% (95% CI 31.1% – 41.5%) with no significant heterogeneity (I2 =0%, p=0.55). Conclusions Our study demonstrated successful outcomes with use of HFNC in an outside of ICU setting among two-thirds of patients with severe COVID–19 pneumonia. Lower room air SpO2 and higher D–dimer levels at presentation were associated with failure of HFNC therapy leading to ICU transfer for endotracheal intubation or death. Also, the results from the systematic review demonstrated similar rates of successful outcomes concluding that HFNC is a viable option with failure rates similar to those of ICU settings in such patients. +
++Objective: Poor metabolic health and certain lifestyle factors have been associated with risk and severity of coronavirus disease 2019 (COVID-19), but data for diet are lacking. We aimed to investigate the association of diet quality with risk and severity of COVID-19 and its intersection with socioeconomic deprivation. Design: We used data from 592,571 participants of the smartphone-based COVID Symptom Study. Diet quality was assessed using a healthful plant-based diet score, which emphasizes healthy plant foods such as fruits or vegetables. Multivariable Cox models were fitted to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) for COVID-19 risk and severity defined using a validated symptom-based algorithm or hospitalization with oxygen support, respectively. Results: Over 3,886,274 person-months of follow-up, 31,815 COVID-19 cases were documented. Compared with individuals in the lowest quartile of the diet score, high diet quality was associated with lower risk of COVID-19 (HR, 0.91; 95% CI, 0.88-0.94) and severe COVID-19 (HR, 0.59; 95% CI, 0.47-0.74). The joint association of low diet quality and increased deprivation on COVID-19 risk was higher than the sum of the risk associated with each factor alone (Pinteraction=0.005). The corresponding absolute excess rate for lowest vs highest quartile of diet score was 22.5 (95% CI, 18.8-26.3) and 40.8 (95% CI, 31.7-49.8; 10,000 person-months) among persons living in areas with low and high deprivation, respectively. Conclusions: A dietary pattern characterized by healthy plant-based foods was associated with lower risk and severity of COVID-19. These association may be particularly evident among individuals living in areas with higher socioeconomic deprivation. +
+Cognitive and Psychological Disorders After Severe COVID-19 Infection - Condition: COVID 19
Interventions: Diagnostic Test: Cognitive assessment; Diagnostic Test: Imaging; Diagnostic Test: Routine care; Other: Psychiatric evaluation
Sponsors: Central Hospital, Nancy, France; Centre Hospitalier Universitaire de Besancon; University Hospital, Strasbourg, France; Centre Hospitalier Régional Metz-Thionville; Centre hospitalier Epinal; Hopitaux Civils de Colmar
Not yet recruiting
MP1032 Treatment in Patients With Moderate to Severe COVID-19 - Condition: COVID-19
Interventions: Drug: MP1032; Drug: Placebo
Sponsors: MetrioPharm AG; Syneos Health, LLC
Not yet recruiting
Efficacy and Safety of XAV-19 for the Treatment of Moderate-to-severe COVID-19 - Condition: COVID-19
Interventions: Drug: XAV-19; Drug: Placebo
Sponsor: Xenothera SAS
Recruiting
Study of Codivir in Patients With COVID-19 - Condition: Covid19
Interventions: Drug: Covidir injections; Diagnostic Test: One Step Test; Diagnostic Test: IgM and IgG dosage; Diagnostic Test: RT-PCR SARS-CoV-2; Diagnostic Test: Screening blood test; Diagnostic Test: ECG; Diagnostic Test: Medical evaluation; Diagnostic Test: NEWS-2 score; Diagnostic Test: WHO score
Sponsors: Code Pharma; Zion Medical
Active, not recruiting
Study to Evaluate the Safety and Concentrations of Monoclonal Antibody Against Virus That Causes COVID-19 Disease. - Condition: COVID-19 Virus Disease
Interventions: Biological: MAD0004J08; Other: Placebo
Sponsors: Toscana Life Sciences Sviluppo s.r.l.; Cross Research S.A.
Active, not recruiting
Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19 - Condition: COVID-19
Interventions: Drug: Vitamin C; Drug: N-acetylcysteine (NAC); Drug: NAC + Bromhexine (BMX)
Sponsors: Universidade Federal do Ceara; Paulista School of Medicine-EPM, UNIFESP; Health Surveillance Secretariat - SVS; Central Laboratory of Public Health of Ceara - LACEN-CE; Leonardo da Vinci Hospital - HLV; São José Hospital for Infectious Diseases - HSJ; Ceará Health Secretariat - SESA; Municipal Health Secretary - SMS-Fortaleza
Not yet recruiting
Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps - Condition: Covid19
Intervention: Other: Osteopathic Manipulative Treatment (OMT)
Sponsors: Western University of Health Sciences; American College of Osteopathic Physicians; American Osteopathic Foundation; Osteopathic Physicians and Surgeons of California; Xavier-Nichols Foundation
Recruiting
Safety and Immunogenicity of LNP-nCOV saRNA-02 Vaccine Against SARS-CoV-2, the Causative Agent of COVID-19 - Condition: COVID-19
Intervention: Drug: LNP-nCOV saRNA-02 Vaccine
Sponsor: MRC/UVRI and LSHTM Uganda Research Unit
Not yet recruiting
Efficacy of Inhaled Therapies in the Treatment of Acute Symptoms Associated With COVID-19 - Condition: Covid19
Interventions: Drug: inhaled beclametasone; Drug: Inahaled beclomethasone / formoterol / glycopyrronium
Sponsors: UPECLIN HC FM Botucatu Unesp; Chiesi Farmaceutici S.p.A.
Not yet recruiting
Dapsone Coronavirus SARS-CoV-2 Trial (DAP-CORONA) COVID-19 - Condition: COVID-19
Interventions: Drug: Dapsone 85 mg PO BID; Drug: Placebo 85 mg PO BID
Sponsors: McGill University Health Centre/Research Institute of the McGill University Health Centre; Pulmonem Inc.
Not yet recruiting
Clinical Investigation for 2019-nCoV Antigen Saliva Rapid Test Kit and V-CHEK SARS-CoV-2 Antigen Detection Kit to Detect COVID-19 - Condition: Covid19
Intervention: Device: V-CHECK SARS-CoV-2 Antigen Detection Kit and 2019-nCoV Antigen Saliva Rapid Test Kit
Sponsors: Medical College of Wisconsin; Reliable, LLC.
Not yet recruiting
Ivermectin Versus Standard Treatment in Mild COVID-19 - Condition: Covid19
Intervention: Drug: Ivermectin Tablets
Sponsor: Assiut University
Not yet recruiting
Tolerability,Safety of JS016 in SARS-CoV-2 (COVID-19) - Conditions: COVID-19; SARS-CoV-2
Intervention: Drug: Combination Product: JS016 (anti-SARS-CoV-2 monoclonal antibody)
Sponsor: Peking Union Medical College Hospital
Recruiting
Open Label, Single-Center Study Utilizing BIOZEK COVID-19 Antigen Rapid Test - Condition: Covid-19 Testing
Intervention: Diagnostic Test: Biozek Covid-19 Antigen Rapid Test (Saliva)
Sponsor: Mach-E B.V.
Recruiting
SCALE-UP Utah: Community-Academic Partnership to Address COVID-19 Testing Among Utah Community Health Centers - Condition: Covid19
Interventions: Behavioral: Text-Messaging (TM); Behavioral: Patient Navigation (PN)
Sponsors: University of Utah; Association for Utah Community Health; Utah Department of Health; National Institutes of Health (NIH)
Recruiting
Identification of known drugs as potential SARS-CoV-2 Mpro inhibitors using ligand- and structure-based virtual screening - Background: The new coronavirus pandemic has had a significant impact worldwide, and therapeutic treatment for this viral infection is being strongly pursued. Efforts have been undertaken by medicinal chemists to discover molecules or known drugs that may be effective in COVID-19 treatment - in particular, targeting the main protease (Mpro) of the virus. Materials & methods: We have employed an innovative strategy - application of ligand- and structure-based virtual screening - using a special…
Rationale, study design and implementation of the LUCINDA Trial: Leuprolide plus cholinesterase inhibition to reduce neurologic decline in Alzheimer’s - The LUCINDA Trial (Leuprolide plus Cholinesterase Inhibition to reduce Neurologic Decline in Alzheimer’s) is a 52 week, randomized, placebo-controlled trial of leuprolide acetate (Eligard) in women with Alzheimer’s disease (AD). Leuprolide acetate is a gonadotropin analogue commonly used for hormone-sensitive conditions such as prostate cancer and endometriosis. This repurposed drug demonstrated efficacy in a previous Phase II clinical trial in those women with AD who also received a stable dose…
Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2 - COVID-19 is a global crisis of unimagined dimensions. Currently, Remedesivir is only fully licensed FDA therapeutic. A major target of the vaccine effort is the SARS-CoV-2 spike-hACE2 interaction, and assessment of efficacy relies on time consuming neutralization assay. Here, we developed a cell fusion assay based upon spike-hACE2 interaction. The system was tested by transient co-transfection of 293T cells, which demonstrated good correlation with standard spike pseudotyping for inhibition by…
SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating global pandemic, infecting over 43 million people and claiming over 1 million lives, with these numbers increasing daily. Therefore, there is urgent need to understand the molecular mechanisms governing SARS-CoV-2 pathogenesis, immune evasion, and disease progression. Here, we show that SARS-CoV-2 can block IRF3 and NF-κB activation early during virus infection. We also identify that the SARS-CoV-2 viral…
Mechanism of inhibition of SARS-CoV-2 M(pro) by N3 peptidyl Michael acceptor explained by QM/MM simulations and design of new derivatives with tunable chemical reactivity - The SARS-CoV-2 main protease (M^(pro)) is essential for replication of the virus responsible for the COVID-19 pandemic, and one of the main targets for drug design. Here, we simulate the inhibition process of SARS-CoV-2 M^(pro) with a known Michael acceptor (peptidyl) inhibitor, N3. The free energy landscape for the mechanism of the formation of the covalent enzyme-inhibitor product is computed with QM/MM molecular dynamics methods. The simulations show a two-step mechanism, and give structures…
Inhibitors of thiol-mediated uptake - Ellman’s reagent has caused substantial confusion and concern as a probe for thiol-mediated uptake because it is the only established inhibitor available but works neither efficiently nor reliably. Here we use fluorescent cyclic oligochalcogenides that enter cells by thiol-mediated uptake to systematically screen for more potent inhibitors, including epidithiodiketopiperazines, benzopolysulfanes, disulfide-bridged γ-turned peptides, heteroaromatic sulfones and cyclic thiosulfonates,…
A microscopic description of SARS-CoV-2 main protease inhibition with Michael acceptors. Strategies for improving inhibitor design - The irreversible inhibition of the main protease of SARS-CoV-2 by a Michael acceptor known as N3 has been investigated using multiscale methods. The noncovalent enzyme-inhibitor complex was simulated using classical molecular dynamics techniques and the pose of the inhibitor in the active site was compared to that of the natural substrate, a peptide containing the Gln-Ser scissile bond. The formation of the covalent enzyme-inhibitor complex was then simulated using hybrid QM/MM free energy…
Hyper-Enriched Anti-RSV Immunoglobulins Nasally Administered: A Promising Approach for Respiratory Syncytial Virus Prophylaxis - Respiratory syncytial virus (RSV) is a public health concern that causes acute lower respiratory tract infection. So far, no vaccine candidate under development has reached the market and the only licensed product to prevent RSV infection in at-risk infants and young children is a monoclonal antibody (Synagis^(®)). Polyclonal human anti-RSV hyper-immune immunoglobulins (Igs) have also been used but were superseded by Synagis^(®) owing to their low titer and large infused volume. Here we report a…
Therapeutic Targeting of Transcription Factors to Control the Cytokine Release Syndrome in COVID-19 - Treatment of the cytokine release syndrome (CRS) has become an important part of rescuing hospitalized COVID-19 patients. Here, we systematically explored the transcriptional regulators of inflammatory cytokines involved in the COVID-19 CRS to identify candidate transcription factors (TFs) for therapeutic targeting using approved drugs. We integrated a resource of TF-cytokine gene interactions with single-cell RNA-seq expression data from bronchoalveolar lavage fluid cells of COVID-19 patients….
Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19 - CONCLUSION: Local use of ivermectin mucoadhesive nanosuspension nasal spray is safe and effective in treatment of patients with mild COVID-19 with rapid viral clearance and shortening the anosmia duration.
Structure-guided design of a perampanel-derived pharmacophore targeting the SARS-CoV-2 main protease - There is a clinical need for direct-acting antivirals targeting SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, to complement current therapeutic strategies. The main protease (M^(pro)) is an attractive target for antiviral therapy. However, the vast majority of protease inhibitors described thus far are peptidomimetic and bind to the active-site cysteine via a covalent adduct, which is generally pharmacokinetically unfavorable. We have reported the optimization of an existing…
It - ObjectiveMindStep™ is an Australian low-intensity cognitive behaviour therapy (LICBT) program for individuals with mild-to-moderate symptoms of anxiety and depression. UK-produced LICBT guided self-help (GSH) materials were originally used in the MindStep™ program. In 2017, Australian LICBT GSH materials were developed to better suit Australian users. This study explored whether the Australian-produced materials continued to achieve the benchmark recovery rates established in the UK and…
Structural basis of covalent inhibitory mechanism of TMPRSS2-related serine proteases by camostat - SARS-CoV-2 is the viral pathogen causing the COVID19 global pandemic. No effective treatment for COVID-19 has been established yet. TMPRSS2 is essential for viral spread and pathogenicity by facilitating the entry of SARS-CoV-2 onto host cells. The protease inhibitor camostat, an anticoagulant used in the clinic, has potential anti-inflammatory and anti-viral activities against COVID-19. However, the potential mechanisms of viral resistance and antiviral activity of camostat are unclear. Herein,…
SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesionin endothelial cells - Increased mortality in COVID-19 often associates with microvascular complications. We have recently shown that SARS-CoV-2 spike protein promotes an inflammatory cytokine IL-6/IL-6R induced trans-signaling response and alarmin secretion. Virus infected or spike transfected human epithelial cells exhibited an increase in senescence state with the release of senescence associated secretory proteins (SASP) related inflammatory molecules. Introduction of BRD4 inhibitor AZD5153 to senescent epithelial…
Structure-based virtual screening of bioactive compounds from Indonesian medical plants against severe acute respiratory syndrome coronavirus-2 - Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a virus that causes the infectious disease coronavirus disease-2019. Currently, there is no effective drug for the prevention and treatment of this virus. This study aimed to identify secondary metabolites that potentially inhibit the key proteins of SARS-CoV-2. This was an in silico molecular docking study of several secondary metabolites of Indonesian herbal plant compounds and other metabolites with antiviral testing history….
SARS-CoV-2 anti-viral therapeutic - - link
폐마스크 밀봉 회수기 - 본 발명은 마스크 착용 후 버려지는 일회용 폐마스크를 비닐봉지에 넣은 후 밀봉하여 배출함으로써, 2차 감염을 예방하고 일반 생활폐기물과 선별 분리 배출하여 환경오염을 방지하는 데 그 목적이 있다. - link
백신 냉각 및 해동 기능을 갖는 백신 보관장치 - 본 발명은 백신 냉각 및 해동 기능을 갖는 백신 보관장치에 관한 것으로, 상, 하부하우징의 제1상, 하부누출방지공간에 냉각물질이 충입된 냉각파이프를 설치하되, 제2상, 하부누출방지공간에 가열물질이 충입된 가열파이프를 설치하여, 구획판부에 의해 구획된 백신냉각공간 및 백신해동공간 각각을 냉각 및 가열하고, 보조도어를 통해 백신냉각공간 내에 수용된 백신을 구획판부의 백신출구도어를 통해 백신해동공간으로 이동시켜, 백신해동공간 내에서 백신을 해동함으로써, 즉시 사용이 가능한 백신을 인출도어를 통해 인출할 수 있다. 본 발명에 따르면, 냉각파이프에 저장된 냉매에 의해 백신냉각공간 내의 온도가 극저온 상태로 변화되고, 극저온 상태를 유지하는 백신냉각공간 내에 백신을 저장하여, 안전하게 보관 할 수 있으며, 백신냉각공간 내의 백신을 백신해동공간 내로 이동시켜, 백신해동공간 내에서 백신을 해동할 수 있고, 이 해동된 백신을 인출도어를 통해 인출한 후 즉시 사용할 수 있어 백신을 해동하는 시간이 단축되며, 보조도어를 통해 백신냉각공간 내의 백신을 백신해동공간으로 이동시켜, 백신이 외기에 노출될 우려가 없으며, 백신냉각공간 내의 백신을 백신해동공간으로 이동시키거나 또는 인출도어를 통해 백신 인출시 정렬장치가 백신을 보조도어 및 인출도어 직하방에 자동 위치시킨다. - link
COST EFFECTIVE PORTABLE OXYGEN CONCENTRATOR FOR COVID-19 - - link
백신 인출용 보조도어를 갖는 백신 저온 보관장치 - 본 발명은 백신정렬 기능을 갖는 백신 저온 보관장치에 관한 것으로, 상, 하부하우징의 이중 격벽 안에 냉매가 충입된 냉매파이프를 설치하여, 이 냉매파이프에 의해 상, 하부하우징의 백신 보관 공간이 극저온 상태를 유지하도록 하고, 하부하우징의 가이드벽 사이에 수용된 백신을 정렬장치로 가압하여, 상부하우징의 보조도어 직하방에 백신이 위치되도록 하되, 이때, 보조도어를 개방하여 하부하우징 내에 수용된 백신을 인출하면, 정렬장치가 가이드벽 사이에 수용된 백신을 보조도어 방향으로 밀어내어, 보조도어 직하방에 백신이 순차적으로 자동 위치된다. 본 발명에 따르면, 상, 하부하우징의 이중 격벽 내에 냉매 파이프가 설치되어, 이 냉매 파이프에 저장된 냉매에 의해 백신 보관공간 내의 온도가 극저온 상태로 변화되고, 이 극저온 상태를 유지하는 백신 보관공간 내에 백신을 저장하여, 안전하게 보관 할 수 있으며, 수분이나 외부 공기 유입이 차단되어 백신을 안전하게 보관되고, 온도계와 압력계를 이용하여 백신 보관공간과 냉매 압력을 실시간으로 감지할 수 있고, 보조도어를 통해 백신 보관공간 내의 백신을 독립적으로 인출할 수 있으며, 보조도어를 통해 백신 인출시 정렬장치가 백신을 보조도어 방향으로 밀어내어, 보조도어 직하방에 백신이 자동 위치되고, 외기 유입 방지로 백신 보관공간 내의 온도가 극저온 상태로 유지된다. - link
SAFE TOUCH ANTI VIRAL LUGGAGE TROLLEY HANDLE - The invention is directed to a safe-touch, anti-viral luggage trolley handle, comprising PVC plastic with the addition of a silver-based antimicrobial additive. - link
METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA) - - link
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Erweiterbare Desinfektionsvorrichtung, umfassend: einen Hauptkörper, der eine umgekehrt U-förmige Basisplatte aufweist, wobei die umgekehrt U-förmige Basisplatte mit einer Öffnung versehen ist und jeweils eine Seitenplatte sich von zwei Seiten der umgekehrt U-förmigen Basisplatte nach außen erstreckt; und mindestens eine Desinfektionslampe, die in den auf zwei Seiten des Hauptkörpers befindlichen Seitenplatten angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst.
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Einfache Sterilisationsvorrichtung, mit einem Hauptkörper (11), der in Längsrichtung einen ersten Plattenabschnitt (111) und in Querrichtung einen zweiten Plattenabschnitt (112) aufweist, wobei der erste Plattenabschnitt (111) und der zweite Plattenabschnitt (112) L-förmig miteinander verbunden sind; und einer Sterilisationslampe (12), die an dem Hauptkörper (11) angeordnet ist und eine Lichtemissionseinheit (121), eine Sensoreinheit (122), eine Steuereinheit (123) und eine Stromeinheit (124) aufweist.
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Klemmarme aufweisende Desinfektionsvorrichtung, umfassend: einen Hauptkörper; eine Desinfektionslampe, die im Hauptkörper angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst; einen Klemmabschnitt, der auf einer Seite des Hauptkörpers angeordnet ist, wobei der Klemmabschnitt zwei gegenüberliegende Greifbacken umfasst, wobei mindestens eine der beiden Greifbacken mit einer Schwenkachse versehen ist, wobei ein Klemmraum durch passgenaues Schließen der beiden Greifbacken entsteht und die beiden Greifbacken jeweils mit einem Durchgangsloch versehen sind; einen Befestigungsabschnitt, der durch die Durchgangslöcher der beiden Greifbacken hindurchgeführt ist;und ein Schild, das auf einer Seite des Klemmabschnitts angeordnet und mit einem Aufnahmeloch versehen ist.
Bipartisanship Lives, and Biden Takes a Bow - Finally, Infrastructure Week is for real. - link
After the Lost Cause - Why are politics so consumed with the past? - link
Can Congress Insure Fair Elections? - The legal scholar Rick Hasen discusses the dangers of election subversion and voter suppression. - link
It’s Not the Heat—It’s the Humanity - Rising air temperatures remind us that our bodies have real limits. - link
New York City’s Mayoral Election Didn’t Meet the Moment - The field was too big, the campaigning was too weird, and none of the candidates took the full measure of the city that they hoped to govern. - link
+One of the real challenges that we’re facing is that we don’t have a lot of information +
++Social media has drastically restructured the way we communicate in an incredibly short period of time. We can discover, “Like,” click on, and share information faster than ever before, guided by algorithms most of us don’t quite understand. +
++And while some social scientists, journalists, and activists have been raising concerns about how this is affecting our democracy, mental health, and relationships, we haven’t seen biologists and ecologists weighing in as much. +
++That’s changed with a new paper published in the prestigious science journal PNAS earlier this month, titled “Stewardship of global collective behavior.” +
++Seventeen researchers who specialize in widely different fields, from climate science to philosophy, make the case that academics should treat the study of technology’s large-scale impact on society as a “crisis discipline.” A crisis discipline is a field in which scientists across different fields work quickly to address an urgent societal problem — like how conservation biology tries to protect endangered species or climate science research aims to stop global warming. +
++The paper argues that our lack of understanding about the collective behavioral effects of new technology is a danger to democracy and scientific progress. For example, the paper says that tech companies have “fumbled their way through the ongoing coronavirus pandemic, unable to stem the ‘infodemic’ of misinformation” that has hindered widespread acceptance of masks and vaccines. The authors warn that if left misunderstood and unchecked, we could see unintended consequences of new technology contributing to phenomena such as “election tampering, disease, violent extremism, famine, racism, and war.” +
++It’s a grave warning and call to action by an unusually diverse swath of scholars across disciplines — and their collaboration indicates how concerned they are. +
++Recode spoke with the lead author of the paper, Joe Bak-Coleman, a postdoctoral fellow at the University of Washington Center for an Informed Public , as well as co-author Carl Bergstrom, a biology professor at the University of Washington, to better understand this call for a paradigm shift in how scientists study the technology we use every day. +
++The two interviews have been combined and lightly edited for length and clarity. +
++You tweeted that this paper is one of the most important ones you’ve published yet. Why? +
++My original background is in infectious disease epidemiology, respiratory viruses. And so I was able to do some stuff that’s reasonably important during Covid. What I’m doing there is really filling in the details in a well-established framework. So it’s more, you know, dotting the i’s and crossing the t’s. +
++And I think what’s really important about this paper is that it’s not doing that at all. It’s saying, “Here’s a massive problem, and the way to conceptualize it, that is critically important for the future. “ +
++And, you know, it’s suggesting an alarm going off upstairs. It’s a call to arms. It’s saying, “Hey, we’ve got to solve this problem, and we don’t have a lot of time.” +
++And what is that problem? What are you sounding the alarm bell on? +
++My sense is that social media in particular — as well as a broader range of internet technologies, including algorithmically driven search and click-based advertising — have changed the way that people get information and form opinions about the world. +
++And they seem to have done so in a manner that makes people particularly vulnerable to the spread of misinformation and disinformation. +
++Just as one example: A paper — a poorly done research paper — can come out suggesting that hydroxychloroquine might be a treatment for Covid. And in a matter of days, you have world leaders promoting it, and people struggling to get [this medicine], and it being no longer available to people who need it for treatment of other conditions. Which is actually a serious health problem. +
++So you can have these bits of misinformation that explode at unprecedented velocity in ways that they wouldn’t have prior to this information ecosystem. +
++[Now], you can create large communities of people that hold constellations of beliefs that are not grounded in reality, such as [the conspiracy theory] QAnon. You can have ideas like anti-vaccination ideas spread in new ways. You can create polarization in new ways. +
++And [you can] create an information environment where misinformation seems to spread organically. And also [these communities can] be extremely vulnerable to targeted disinformation. We don’t even know the scope of that yet. +
++The question we were trying to answer was, “What can we infer about the course of society at scale, given what we know about complex systems?” +
++It’s kind of how we use mice models or flies to understand neuroscience. Part of this came back to animal societies — namely groups — to understand what they tell us about collective behavior in general, but also complex systems more broadly. +
++So our goal is to take that perspective and then look at human society with that. And one of the things about complex systems is they have a finite limit to perturbation. If you disturb them too much, they change. And they often tend to fail catastrophically, unexpectedly, without warning. +
++We see this in financial markets — all of a sudden, they crash out of nowhere. +
++My hope is very much that this [paper] will sort of galvanize people. The issues that are in this paper are ones that people have been thinking about from many, many different fields. It’s not like these are new issues entirely. +
++It’s rather that I think this paper will hopefully really highlight the magnitude of what’s happened and the urgency of fixing it. Hopefully, it’ll galvanize some kind of transdisciplinary collaborations. +
++So it’s important because it says this needs to be a crisis discipline, this is something that we don’t understand. We don’t have a theory for how all of these changes are affecting the way that people come to form their beliefs and opinions, and then use those to make decisions. And yet, that’s all changing. It’s happening. … +
++There’s a misperception that we’re saying, “Exposure to ads is bad — that’s causing the harm.” That’s not what we’re saying. Exposure to ads may or may not be bad. What we’re concerned about is the fact that this information ecosystem has developed to optimize something orthogonal to things that we think are extremely important, like being concerned about the veracity of information or the effect of information on human well-being, on democracy, on health, on the ecosystem. +
++Those issues are just being left to sort themselves out, without a whole lot of thought or guidance around them. +
++That puts it in this crisis discipline space. It’s like climate science where you don’t have time to sit down and work out everything definitively. This paper is essentially saying something quite similar — that we don’t have time to wait. We need to start addressing these problems now. +
++What do you say to the people who think this is not really a crisis and argue that people had similar concerns when the printing press came out that now seem alarmist? +
++Well, with the printing press, I would push back. The printing press came out and upended history. We’re still recovering from the capacity that the printing press gave to Martin Luther. The printing press radically changed the political landscape in Europe. And, you know, depending on whose histories you go by, you had decades if not centuries of war [after it was introduced]. +
++So, did we somehow recover? Sure we did. Would it have been better to do it in a stewarded way? I don’t know. Maybe. These major transitions in information technology often cause collateral damage. We tend to hope that they also bring about a tremendous amount of good as we move toward human knowledge and all of that. But even the fact that you’ve survived doesn’t mean that it’s not worth thinking about how to get through it smoothly. +
++It reminds me of one of the least intelligent critiques of the [Covid-19] vaccines that we’re using now: “We didn’t have vaccines during the Black Death plague. And we’re still here.” We are, but it took out a third of the population of Europe. +
++Right, so there is pain and suffering that happened with all those transformational technologies as well. +
++Yeah. So I think it’s important to recognize that. It’s still possible to mitigate harm as you go through a transformation, even if you know you’re going to be fine. I also don’t think it’s completely obvious that we are going to be fine on the other end. +
++One of the really key messages of the paper is that there tends to be this general trust that everything will work out, that people will eventually learn to screen sources of information, that the market will take care of it. +
++And I think one of the things that the paper is saying is that we’ve got no particular reason to think that that’s right. There’s no reason why good information will rise to the top of any ecosystem we’ve designed. So we’re very concerned about that. +
++One important defense of social media is that Facebook and Twitter can be places where people share new ideas that are not mainstream that end up being right. Sometimes media gatekeepers can get things wrong and social media can allow better information to come out. For example, some people like Zeynep Tufekci were sounding the alarm on the pandemic early, largely on Twitter, back in February 2020, far ahead of the CDC and most journalists. +
++Yeah, to look at the net, you have to look at the net influence of the system, right? If somebody on social media has things right but if the net influence on social media is to promote anti-vaccination sentiment in the United States to the point that we’re not going to be able to reach herd immunity, it doesn’t let social media off the hook. … +
++I was enormously optimistic about the internet in the ’90s. [I thought] this really was going to remove the gatekeepers and allow people who did not have financial, social, and political capital to get their stories out there. +
++And it’s certainly possible for all that to be true and for the concerns that we express in our paper to also be correct. +
++Democratizing information has had profound effects, especially for marginalized, underrepresented communities. It gives them the ability to rally online, have a platform, and have a voice. And that is fantastic. At the same time, we have things like genocide of Rohingya Muslims and an insurrection at the Capitol happening as well. And I hope that it’s a false statement to say we have to have those growing pains to have the benefits. +
++How much do we know about whether [misinformation] has increased in the past year or five years, 10 years, and by how much? +
++That’s one of the real challenges that we’re facing, actually, is that we don’t have a lot of information. We need to figure out how, to what degree, people have been exposed to misinformation, to what degree is that influencing subsequent online behavior. All of this information is held exclusively by the tech companies that are running these platforms. +
++[Editor’s note: Most major social media companies work with academics who research their platforms’ effects on society, but the companies restrict and control how much information researchers can use.] +
++What does treating the impact of social media as a crisis discipline mean? +
++For me, a crisis discipline is a situation where you don’t have all of the information that you need to know exactly what to do, but you don’t have time to wait to figure it out. +
++This was the situation with Covid in February or March 2020. We’re definitely in that position with global climate change. We’ve got better models than we did 20 years ago, but we still don’t have a complete description of how that system works. And yet, we certainly don’t have time to wait around and figure all that out. +
++And here, I think that the speed with which social media, combined with a whole number of other things, has led to very widespread disinformation — [that] here in the United States [is] causing major political upheaval — is striking. How many more elections do you think we have before things get substantially worse? +
++So there are these super-hard problems that take radical transdisciplinary work. We need to figure out how to come together and talk about all that. But at the same time, we have to be taking actions. +
++How do you respond to the chicken-and-egg argument? You hear defenders of technology say, “We’re just seeing real-world polarization reflected online,” but there’s no proof that the internet is causing polarization. +
++This should be a familiar argument. This is what Big Tobacco used, right? This is Merchants of Doubt stuff. They said, “Well, you know, yeah, sure, lung cancer rates are going up, especially among smokers — but there’s no proof it’s been caused by that.” +
++And now we’re hearing the same thing about misinformation: “Yeah, sure, there’s a lot of misinformation online, but it doesn’t change anyone’s behavior.” But then all of a sudden you got a guy in a loincloth with buffalo horns running around the Capitol building. +
++The paper calls for people to more urgently understand the impacts of these new rapid advancements in communication technology in the past 15 years. Do you think that this isn’t being addressed enough by academic scientists, government leaders, or companies? +
++There’s been a lot of work that’s been done here, and I don’t think we’re trying to reinvent that wheel at all. But I think what we’re really trying to do is just highlight the need for urgent action and draw these parallels to climate change and to conservation biology, where they’ve been dealing with really similar problems. And the way they’ve structured themselves, like climate change now involves everything from chemists to ecologists. And I think social science tends to be fairly fragmented in subdisciplines, without a lot of connection between them. And trying to bring that together was a major goal of this paper. +
++I’m biased to be very aware of this problem because my job is to report on social media, but it feels like there is a lot of fear and concern about social media’s impact. Misinformation, phone addiction — these seem to be issues that everyday people worry about. Why do you think there still isn’t enough attention on this? +
++When I talk to people about social media, yes, there’s a lot of concern, there’s a lot of negativity, and then there’s bias by being a parent as well. But the focus is often on the individual-level effects. So it’s, “My kids are developing negative issues around self-esteem because of the way that Instagram is structured to get ‘Likes’ for being perfect and showing more of your body.” +
++But there’s less talk about the entire large-scale structural changes that this is inducing. So what we’re saying is, we really want people to look at the large-scale structural changes that these technologies are driving in society. +
+The bipartisan deal is a disappointment on climate change, but it’s only part one. Here’s what could come next. +
++This is not the transformative climate deal that activists have been pushing for. +
++Many of the promises President Joe Biden made on the campaign trail and early in his presidency — to slash rising greenhouse gas emissions and prepare America’s aging infrastructure for a changed climate — were missing from his announcement Thursday that 21 senators had reached a bipartisan $973 billion infrastructure deal. +
++“It is in no way, shape, or form a substitute for a comprehensive climate bill,” Leah Stokes, a UC Santa Barbara political scientist and adviser to the climate advocacy group Evergreen Action, told Vox. On its own, “it could even have some emissions increases, potentially.” +
++But Stokes added that the infrastructure deal should not be considered on its own, because Democrats have a plan for passing more ambitious climate action. +
++Facing Republican opposition, the slim Democratic majority in Congress is pursuing its climate agenda on two tracks. Now that they have an initial bipartisan deal, they will try the once-obscure parliamentary procedure known as reconciliation, which allows Congress to pass budget-related matters through a simple Senate majority — which Democrats have. Top Democrats, from House Speaker Nancy Pelosi to President Biden, say there will be no infrastructure package without a reconciliation bill that includes many of their priorities that were left out of the Senate deal, including those dealing with climate change. +
++Getting both done will be tricky — already some Republicans who had signed on to the bipartisan deal are backing away from it after Biden announced the two-pronged approach, and Democrats will face tense internal debates about how big the reconciliation bill should be. +
++The compromise announced Thursday included a scaled-down version of Biden’s original $2 trillion American Jobs Plan. A large portion of the bipartisan deal, $109 billion, injects funding into repairing and building roads, bridges, and other major projects. There’s $66 billion set aside for passenger and freight rail, $49 billion for public transit, and $55 billion for water infrastructure. Climate actions to lower emissions are among the least ambitious parts of this deal. +
++While it’s not clear which climate policies are on the table now, what’s missing from the infrastructure deal tells us a great deal about what could be coming next. And it’s possible to identify top Democratic priorities by looking closely at everything that dropped out of Biden’s original American Jobs Plan. +
++The bipartisan infrastructure package comes nowhere close to meeting Biden’s goal of cutting US climate pollution 50 percent by 2030 compared to 2005 levels. In some sectors, the funding is a small fraction of what Biden proposed in his American Jobs Plan, and an even smaller fraction of what experts have modeled to transform the economy. But in most cases, there’s no funding at all for cleaning up the power sector and building pollution and addressing racial injustices. +
++Here are key areas that are missing compared to the original American Jobs Plan: +
++“Whether you’re looking at public transit or clean energy, or retrofitting buildings, the economic modeling shows that to meet Biden’s goal of cutting climate pollution in half by 2030, while delivering full employment and advancing racial economic and environmental justice, Congress needs to go much bigger and bolder,” Ben Beachy, director of A Living Economy for Sierra Club, said. +
++The chart below, based on data gathered by the Sierra Club, compares the two plans. One key piece of the Biden plan that’s missing entirely from the bipartisan deal is $400 billion in energy spending dedicated to clean energy tax credits. +
+ ++It’s hard to gauge exactly how much the bill would curb greenhouse gas emissions at this point, but parts of the bipartisan Senate deal would help shrink the US’s carbon footprint. +
++Funding for public transit, electric school buses, and half a million electric vehicle chargers would help cut carbon dioxide emissions from driving. Transportation is the largest source of greenhouse gases in the US, and cars and light trucks account for 60 percent of emissions in the sector. +
++The second-largest source of greenhouse gases in the US is electricity production. The framework doesn’t specifically call for more clean energy on the power grid, but it includes $73 billion for power infrastructure, like transmission. Transmission lines can link areas that need energy with places where wind and solar power are cheap, which can be separated by thousands of miles. This would help boost the business case for wind and solar power. The proposal calls for a new grid authority to facilitate clean energy transmission, and an infrastructure financing authority to help come up with the money to pay for it. +
++Another key climate provision is what the White House called the “largest investment in addressing legacy pollution in American history” — $21 billion allocated to environmental remediation. +
++There are more than 3.2 million abandoned oil and gas wells across the US leaking methane, a potent greenhouse gas, to take just one example. These leaks emit the equivalent emissions of burning 16 million barrels of crude oil per year — and the Environmental Protection Agency says that may be a drastic undercount. +
++Plugging these wells would therefore go a long way toward reducing the US greenhouse gas emissions. And since many of these wells are in rural areas or places with fossil fuel development, stopping leaks could also be a jobs strategy. +
++“It can really help with the transition for oil and gas production workers into remediation, and similarly for some of the coal communities, they could employ a lot of people remediating coal mining,” said Dan Lashof, the US director of the World Resources Institute. “That may not be called out as an economic transition strategy, but I think it should be seen as part of that.” +
++The proposal also calls for $47 billion in spending on resilience, which includes bolstering infrastructure against “the impacts of climate change, cyber attacks, and extreme weather events.” +
++However, the deal also contains elements that observers worry could undermine progress on climate change. The new construction of roads, bridges, and power lines in the proposal is likely to be resource- and energy-intensive. While the White House calls for these investments to be made with “a focus on climate change mitigation,” it’s not clear yet how this would be enforced. +
++“If you put a condition on the federal funding for some of these projects that require using low-carbon concrete and steel, that would improve that aspect of it,” Lashof said. +
++In addition, some of the new infrastructure will go to benefit cars, shipping, and airplanes that use fossil fuels. The proposal calls for $25 billion for airports and $16 billion for ports and waterways, for example. +
++Whether the emissions reductions from the electric vehicles and other environmental line items in the proposal will outweigh the emissions increases from construction and infrastructure for the fossil-fuel-dependent sectors of the economy remains to be seen. That’s why many Democrats also want a separate climate-focused bill to pass alongside the Senate deal. +
++Many Democrats have rallied around the promise “no climate, no deal.” Biden reinforced the message Thursday, saying he will not sign an infrastructure bill without another bill on his desk addressing climate change, a point echoed by both Pelosi and Senate Majority Leader Chuck Schumer. +
++That means Democrats are publicly betting the farm on advancing the second track of their climate strategy: reconciliation. +
++“In effect, that means no reconciliation package, no bipartisan deal,” Beachy told Vox. “Congress must move a big, bold infrastructure package that tackles the climate crisis, curbs injustice and creates millions of good jobs before moving any bipartisan deal.” +
++There are two major caveats to Democrats’ promise: First, the announcement this week was just the broad brushstrokes of a bill, so it’s not a done deal yet. There’s also the mystery about the contents of the reconciliation package — much of which will depend on moderate Democrats such as West Virginia Sen. Joe Manchin. +
++But the possibilities open under reconciliation give climate experts hope that Congress may still meet the gravity of the climate crisis. +
++“I’m very optimistic, to be honest,” Stokes said. “I think that President Biden, Speaker Pelosi, and Leader Schumer are all deeply committed to climate action and we need to make sure they stay committed. The lines have been drawn, and we will be passing a climate bill this summer. I feel pretty certain about that.” +
+Though Chauvin was sentenced to 22.5 years, police violence continues to plague America. +
++In April, people around the country awaited the verdict in the murder trial of former Minneapolis police officer Derek Chauvin. The video of George Floyd, pinned to the ground by Chauvin’s knee for nine minutes and pleading to breathe, had gone viral the summer prior, setting off a wave of protests around the world. After just 10 hours of deliberation, jurors returned with a conviction of second-degree unintentional murder, third-degree murder, and second-degree manslaughter. People took the streets to cry, hug, and gather, the verdict bringing both a sense of relief that an officer was going to face consequences for enacting violence — a rarity in the criminal justice system — and anger, since any outcome wouldn’t bring Floyd back. +
++On Friday, Chauvin was sentenced to 22.5 years in prison, out of a possible 40. This being one of the highest-profile trials of police violence that America has ever known, there was great pressure wrapped up in this moment — as well as the promise of closure. “This is a unique case with an enormous amount of visibility and attention from the entire globe, and if we are honest, it has an impact,” said Christopher Brown, principal attorney at the Brown Firm, which has sued police officers in excessive force cases. +
++But while Chauvin’s punishment will likely send ripples through police departments across the country, Chauvin’s time behind bars still won’t exactly represent justice, activists say. Just hours before the Chauvin verdict was announced on April 20, a police officer shot and killed 16-year-old Ma’Khia Bryant in Ohio. This was after an officer shot and killed Daunte Wright in Brooklyn Center, Minnesota, just 10 miles from the courthouse where the Chauvin trial was underway on April 13. At least 181 Black people were killed at the hands of police between the time of Floyd’s murder on May 25, 2020, and the end of the trial, according to the Mapping Police Violence database. +
++Activists say that the fight for justice will continue long after Chauvin’s sentencing, until police stop killing Black people indiscriminately. +
++“The length of a prison sentence has never been the definition of ‘justice’ for us. Justice would have meant that George Floyd would still be alive today. Justice would mean that our systems seek to address the issues of violence systemically, not be showcasing a bad apple here or there to take the fall,” said Amara Enyia, the policy research coordinator for the Movement for Black Lives. “Justice requires true commitment to changing the systems that have harmed so many communities. We cannot lose sight of that vision — even in the face of a long prison sentence for Chauvin.” +
++On June 3, 44 days after the Chauvin verdict was announced, members of the US Marshals Service task force shot and killed Winston Boogie Smith Jr., a 32-year-old Black man living in Minneapolis. For weeks, Smith’s family’s demanded answers after officials said there was no video evidence of how law enforcement killed him. His death set off protests in the city; during one of them, Deona Knajdek, a 31-year-old mother of two, was killed when someone drove a vehicle into the crowd of protesters. +
++The deaths kept national attention on Minneapolis ahead of Chauvin’s sentencing, strengthening distrust in law enforcement and demonstrating how one conviction does not solve police violence. In the past 10 years, Minneapolis has tried many police reforms, including adopting body cameras, rolling out racial bias training, and changing use of force guidelines, with little success in eliminating police violence, as Vox’s Sean Collins reported. After Floyd’s death, the city’s officers had new protocols to follow, like having to explain why they drew their weapons, banning chokeholds, limiting no-knock warrants, and barring firing at moving vehicles. But activists say the reforms didn’t address the root causes of police violence. +
++Instead, activists continue to work to inform the community about police violence and are taking steps to amend the city charter to cut the police budget and redirect funds to mental health services, violence prevention, and education, after the city council failed to do so after Floyd’s death. A poll conducted in August 2020, two months after the height of the protests, found that the majority of Minneapolis residents (73 percent) were in support of defunding the police. +
++But the permanence of police violence is not just present in Minneapolis. It continues in North Carolina, where police shot and killed Andrew Brown Jr. in late April; and in Hawaii, where police shot and killed Lindani Myeni in early June. And while voters passed police reforms in cities and states across the country in November — from redirecting police funding to housing and other services in Los Angeles to an expansion of a police oversight board in San Francisco — there’s more work to be done to create meaningful legislation and a lasting shift in public opinion, activists say. Polls have shown that support for Black Lives Matter, which reached a record high during protests after Floyd’s death, had dropped from 67 percent last June to 55 percent in September. +
++Lasting change will mean more Americans remaining engaged in anti-racism efforts, in the work of fighting to reimagine an America that lifts all communities, activists say. +
++“This will be George Floyd’s indelible mark on the country’s longstanding need to address police violence against African Americans: promoting important and necessary dialogue on the issue of excessive force by officers who are tasked with protecting and serving,” Brown said. +
++If there is one sign that there has been a significant cultural shift in how Americans think about the racist practices embedded in the county’s institutions, it’s that there’s been pushback to any semblance of a reckoning. This has manifested in bills to ban anti-racist education and limit voting rights in communities of color. “The escalated attacks on Black people have spread not just through police killings, but in the increased attempts to criminalize protest through anti-protest legislation sweeping the country, the voter suppression laws that have been sweeping the country, and even the latest hysteria over critical race theory,” Enyia said. “Those increased attacks only show that we are being effective in our organizing and that we must keep persisting.” +
++
++
Hockey India nominates Sreejesh, Deepika for Khel Ratna; Harmanpreet for Arjuna - Sreejesh has received the Arjuna award in 2015 and the prestigious Padma Shri recognition in 2017.
Kyle Jamieson will become one of the leading all-rounders in world cricket: Sachin Tendulkar - In New Zealand’s emphatic title triumph, Jamieson played a major role with match figures of 7 for 61 in 44 overs along with 21 valuable runs in his team’s first essay
St. Petersburg to host Russian Grand Prix from 2023 - The race, first held in 2014 in Sochi, will switch to the Igora Drive circuit located 54km from the Baltic Sea port city of St Petersburg
England women vs India women ODI: Shafali set for debut as India seeks white-ball course correction - It would be interesting to check out India’s team composition which came under a lot of scanner during the series against the Proteas.
Rijiju announces ‘Cheer Up’ campaign, urges people to extend support to Olympic-bound athletes - The Sports Minister said over 6000 selfie points will be set up in the country for people to show their support
Over 870 cell phones involved in cybercrimes seized from F2P gang - The action against the cyber crime network has been initiated by the Union Home Ministry’s cyber safety wing FCORD.
HC dismisses case against deportation of Sri Lankan national - The court further refrained from imposing costs on the present petitioner after stating that it does want to be harsh on him.
HKCCI demands withdrawal of lockdown cases against traders - They are in bad shape already, punishment will add to their woes, say trade body office-bearers
Petrol price hits century in State capital - The fuel sold at ₹100.16 following the 14th price hike this month
HCs have assured action to fill vacancies, CJI tells Centre - CJI Ramana writes to Law Minister, stresses need for better IT infrastructure
Czech Republic: Deadly tornado sweeps through villages - Five people are killed and at least 150 injured, with the worst-hit areas looking like a war zone.
Valérie Bacot: Freedom for abused French woman who killed husband - Valérie Bacot’s story of abuse shocked France, but she still served a year in jail.
German knife attack: Three dead and five wounded in Würzburg - A Somali man arrested after the attack had been mentally unstable recently, police say.
Russia’s Euro 2020 Covid dilemma - Russia is hosting Euro 2020 matches but the alarm is being sounded about a new wave of coronavirus.
Roman Protasevich: House arrest for man seized in Ryanair Belarus jet drama - Belarus opposition journalist Roman Protasevich was taken from a plane with his girlfriend.
Circling—or cycling—the track at F1’s famous Circuit of the Americas - Be warned: Calves needed to climb all 133 feet of Turn 1 if you’re using a road bike. - link
A well-meaning feature leaves millions of Dell PCs vulnerable - Firmware security tool flaws affect as many as 30m desktops, laptops, and tablets. - link
Even mild COVID in young people often leads to long-term symptoms, study finds - Common symptoms among young adults included fatigue and cognitive problems. - link
We have our best look yet at supervillain Mandarin in new Shang-Chi trailer - “Throughout my life, the Ten Rings gave my family power.” - link
Here’s how Android apps on Windows 11 are going to work - Microsoft is building an Android framework on top of the Windows Subsystem for Linux. - link
+Water. Butane is a lighter fluid. +
+ submitted by /u/Aiden_LeBoeuf
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+Not much, they’re actually pretty light. +
+ submitted by /u/Raevix
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+So the men can think of a solution in silence. +
+ submitted by /u/Organic-Connection-4
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+Pilgrims +
+ submitted by /u/PaolaBean43
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+The father, surprised, answers, “Well son, a woman goes through three phases. In her 20s, a woman’s breasts are like melons, round and firm. In her 30s and 40s, they are like pears, still nice, hanging a bit. After 50 they are like onions.” “Onions?” the son asks. “Yes, you see them and they make you cry.” This infuriated his wife and daughter. The daughter asks, “Mum, how many different kinds of willies are there?” The mother smiles, and says, “Well dear, a man goes through three phases also. In his 20s, his willy is like an oak tree, mighty and hard. In his 30s and 40s it’s like a birch, flexible but reliable. After 50 it’s like a Christmas tree.” “A Christmas tree?” the daughter asks. “Yes,” the mother replies, “dead from the root up, the balls are just for decoration and it only goes up once a year.” +
+ submitted by /u/R_K_Emon
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