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<title>10 July, 2023</title>
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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-preprints">From Preprints</a></li>
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<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
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<li><a href="#from-pubmed">From PubMed</a></li>
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<li><a href="#from-patent-search">From Patent Search</a></li>
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</ul>
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<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
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<ul>
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<li><strong>Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection</strong> -
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<div>
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SARS-CoV-2 Omicron variants emerged in 2022 with >30 novel amino acid mutations in the spike protein alone. While most studies focus on receptor binding domain changes, mutations in the C-terminus of S1 (CTS1), adjacent to the furin cleavage site, have largely been ignored. In this study, we examined three Omicron mutations in CTS1: H655Y, N679K, and P681H. Generating a SARS-CoV-2 triple mutant (YKH), we found that the mutant increased spike processing, consistent with prior reports for H655Y and P681H individually. Next, we generated a single N679K mutant, finding reduced viral replication in vitro and less disease in vivo. Mechanistically, the N679K mutant had reduced spike protein in purified virions compared to wild-type; spike protein decreases were further exacerbated in infected cell lysates. Importantly, exogenous spike expression also revealed that N679K reduced overall spike protein yield independent of infection. Although a loss-of-function mutation, transmission competition demonstrated that N679K had a replication advantage in the upper airway over wild-type SARS-CoV-2 in hamsters, potentially impacting transmissibility. Together, the data show that N679K reduces overall spike protein levels during Omicron infection, which has important implications for infection, immunity, and transmission.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.04.17.536926v2" target="_blank">Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection</a>
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</div></li>
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<li><strong>A large-scale serological survey in pets from October 2020 through June 2021 in France shows significantly higher exposure to SARS-CoV-2 in cats</strong> -
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<div>
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect many animals, including pets such as dogs and cats. Many studies have documented infection in companion animals by bio-molecular and serological methods. However, only a few have compared seroprevalence in cats and dogs from the general population, and these studies were limited by small sample sizes and collections over short periods. Our goal was to obtain a more accurate evaluation of seroprevalence in companion animals in France and to determine whether cats and dogs differ in their exposure to SARS-CoV-2. For this purpose, we conducted an extensive SARS-CoV-2 serological survey of 2036 cats and 3577 dogs sampled by veterinarians during medical examinations in clinics throughout France. Sampling was carried out from October 2020 through June 2021, a period encompassing the second and third waves of SARS-CoV-2 infections in humans in the country. Using a microsphere immunoassay targeting receptor binding domain and trimeric spike protein, we found 7.1% seroprevalence in pets, in a subset of 308 seropositive samples, 26.3% had neutralizing antibodies. We found that cats were significantly more likely to test positive than dogs, with seropositivity rates of 9.3% and 5.9% in cats and dogs, respectively. Finally, data for both species showed that seroprevalence was lower in older animals and was not associated with the date of sampling or the sex of the animal. Our results show that cats are significantly more sensitive to SARS-CoV-2 than dogs, in line with experimental studies showing that cats are more susceptible than dogs. This study reinforces that pets are commonly infected or exposed to SARS-CoV-2, emphasizing the importance of a One-Health approach to the SARS-CoV-2 pandemic and raising the question of vaccination of companion animals in close contact with humans.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.12.23.521567v3" target="_blank">A large-scale serological survey in pets from October 2020 through June 2021 in France shows significantly higher exposure to SARS-CoV-2 in cats</a>
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</div></li>
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<li><strong>Assessing the Impact of COVID-19 Pandemic on Vulnerable Populations in Bangladesh</strong> -
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<div>
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COVID-19 has affected all classes of people over the world in many ways. In major cases, the impact of COVID-19 on vulnerable group of people is overlooked though they are the major part of the society. Thus, this paper aims at investigating the impacts of COVID-19 on vulnerable people in Bangladesh intensively. Using literature review and case studies, this paper finds some interesting findings. The daily income of poor classes of people like day laborers, Rickshaw pullers, transport workers and so on reduced by 64.37 percent during COVID-19 situation. On the other hand, about 3.7 million new poor emerged amid this pandemic. Amid this pandemic, about 50 percent of women-led enterprises are laying off 76-100 percent of their workers while about 2.14 million garment workers were laid off. More effective policies should be taken to tackle the adverse impacts of COVID-19 pandemic on vulnerable populations than what is already taken by the government and NGOs.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/7d8gc/" target="_blank">Assessing the Impact of COVID-19 Pandemic on Vulnerable Populations in Bangladesh</a>
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</div></li>
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<li><strong>Different paths to COVID-19’s conspiratorial beliefs for the religious and spiritual: The roles of analytic and open-minded thinking</strong> -
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<div>
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With the threat of COVID-19, conspiratorial beliefs have proliferated, and people’s religiosity has risen. However, religiosity may only capture a narrow range of people’s meta-physical beliefs, spirituality may capture other aspects, and both of which may be associated with conspiratorial beliefs differently. To better understand the distinction between these traits, in a community sample of 662 Poles, we examined the correlations between them and misperceptions about COVID-19 (i.e., conspiracy and false factual beliefs) and the mediating role of analytic thinking and a tendency to be open-minded about evidence. Religiosity and spirituality were associated with misperceptions—directly and indirectly—but the associations were positive in the former and negative in the latter. The research points to the importance of studying both religiosity and spirituality in the context of cognition and misperceptions.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/zsv89/" target="_blank">Different paths to COVID-19’s conspiratorial beliefs for the religious and spiritual: The roles of analytic and open-minded thinking</a>
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</div></li>
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<li><strong>Economic geography of contagion: A study on Covid-19 outbreak in India</strong> -
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<div>
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We propose a mechanism based on regional inequality in economic activity to explain the heterogeneity in the spread of Covid-19 and test it using data from India. The contagion is expected to spread at a higher rate in regions characterized by greater movements of goods and service. We argue that mobility will be higher in regions with greater degree of intra-regional inequality in economic activity. Such regions are usually characterized by core-periphery economic structure in which the periphery remains dependent on the core for the supply of jobs, goods, and services. Such dependence leads to greater degree of mobility between the core and periphery which in turn leads to higher rate of contagion. Using nightlights data to measure regional inequality, we find evidence in support of our hypothesis. Using mobility data, we provide direct evidence in support of our proposed channel; the positive relationship between regional inequality and Covid-19 infection is driven by mobility. Our findings suggest that policy responses to contain Covid-19 contagion needs to be heterogeneous across India where the priority areas can be chosen ex ante based on a regional inequality-based criterion.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/gp2wr/" target="_blank">Economic geography of contagion: A study on Covid-19 outbreak in India</a>
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</div></li>
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<li><strong>Antimicrobial peptides and other potential biomarkers of critical illness in Sars-CoV-2 patients with acute kidney injury</strong> -
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Antimicrobial peptides (AMPs) are a complex network of 10-100 amino acid sequence molecules, widely distributed in Nature. Even though more than 300 AMPs have been described in mammals, cathelicidins and defensins remain the most investigated to date. Some publications examined the role of AMPs in COVID-19, but the findings are preliminary and in vivo studies are still lacking. Here, we report the plasma levels of five AMPs (LL-37, α-defensin 1, α-defensin 3, β-defensin 1 and β-defensin 3) and five cytokines (tumor necrosis factor-α, interleukin-1β, interleukin-6, interleukin-10, interferon-gamma and monocyte chemoattractant protein-1), in 15 healthy volunteers, 36 COVID-19 patients without Acute Kidney Injury (AKI) and 17 COVID-19 patients with AKI, since AKI is a well-known marker of worse prognosis in Sars-CoV-2 infections. We found increased levels of α-defensin 1, α-defensin 3 and β-defensin 3, but not LL-37 or β-defensin 3, in our COVID-19 population, when compared with the healthy controls, in conjunction with higher levels of interleukin-6, interleukin-10, interferon-gamma and monocyte chemoattractant protein-1, putting in evidence that these AMPs and cytokines may have an important role in the systemic inflammatory response and tissue damage that characterizes severe COVID-19.
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</p>
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.07.08.23292389v1" target="_blank">Antimicrobial peptides and other potential biomarkers of critical illness in Sars-CoV-2 patients with acute kidney injury</a>
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</div></li>
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<li><strong>COVID-19 and socioeconomic context in Bangladesh: Discussion from a gendered point of view</strong> -
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<div>
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The COVID-19 affected communities and the economy beyond public health. The epidemic is expected to increase global poverty and inequality, making it crucial to study its effects. Several international organisations determined that a “new recession” was underway due to the global pandemic’s destructive effects on the financial, social, and personal spheres. Despite their best efforts, many undeveloped nations are fighting the pandemic’s aftereffects. Bangladesh is like other nations. Global economic and social changes will lead to new difficulties in the near future. Thus, studying COVID’s effects from a variety of perspectives, including gender, is crucial and timely. This paper explores the aftermath of the epidemic, focusing on the plight of women workers. In doing so, it sheds light on a particularly marginalised group, including maids and housekeepers, who have been denied benefits and recognition for their job.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/puxk2/" target="_blank">COVID-19 and socioeconomic context in Bangladesh: Discussion from a gendered point of view</a>
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</div></li>
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<li><strong>Psychometric Evaluation of The Fear of COVID-19 Scale Among Chinese Population</strong> -
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<div>
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Background. Fear is a negative emotional reaction to or persistent worry over an imminent public health event like COVID-19. The COVID-Fear Scale was developed in many countries, but not in China. The current study aims to examined the psychometric properties of Chinese version of the Fear of COVID-19 Scale. Methods. Translation into Chinese and back-translation into English were conducted firstly. Item analysis and exploratory factor analysis in Sample 1, followed by validity tests in Sample 2). Likely, test-rest reliability was conducted in Sample 3. Results. A bifactor structure of Chinese version of FCV-19S with a general fear factor and two orthogonal group factors with fear thoughts and physical response was confirmed. Besides, it has good internal consistency reliability (α=.92), composite reliability (CR=.92) and validity correlation validity. Conclusion. The results of the present study confirmed that the Chinese version of FCV-19S has good psychometric properties in the Chinese communities.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/t5jne/" target="_blank">Psychometric Evaluation of The Fear of COVID-19 Scale Among Chinese Population</a>
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</div></li>
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<li><strong>Epidemiology of mental health problems in COVID-19: a review</strong> -
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<div>
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The novel coronavirus disease (COVID-19) has become a pandemic affecting health and wellbeing globally. In addition to the physical health, economic, and social implications, the psychological impacts of this pandemic are increasingly being reported in the scientific literature. This narrative review reflected on scholarly articles on the epidemiology of mental health problems in COVID-19. The current literature suggests that people affected by COVID-19 may have a high burden of mental health problems, including depression, anxiety disorders, stress, panic attack, irrational anger, impulsivity, somatization disorder, sleep disorders, emotional disturbance, posttraumatic stress symptoms, and suicidal behavior. Moreover, several factors associated with mental health problems in COVID-19 are found, which include age, gender, marital status, education, occupation, income, place of living, close contact with people with COVID-19, comorbid physical and mental health problems, exposure to COVID-19 related news and social media, coping styles, stigma, psychosocial support, health communication, confidence in health services, personal protective measures, risk of contracting COVID-19, and perceived likelihood of survival. Furthermore, the epidemiological distribution of mental health problems and associated factors were heterogeneous among the general public, COVID-19 patients, and healthcare providers. The current evidence suggests that a psychiatric epidemic is cooccurring with the COVID-19 pandemic, which necessitates the attention of the global health community. Future epidemiological studies should emphasize on psychopathological variations and temporality of mental health problems in different populations. Nonetheless, multipronged interventions should be developed and adopted to address the existing psychosocial challenges and promote mental health amid the COVID-19 pandemic.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://psyarxiv.com/q8e5u/" target="_blank">Epidemiology of mental health problems in COVID-19: a review</a>
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</div></li>
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<li><strong>The blending of bending: how we engage with the world of Avatar: The Last Airbender through memes</strong> -
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<div>
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People often use memes to express their ideological stance on real world events. This study departs from a recent COVID-19-related meme which makes use of elements known from the animated television series Avatar: The Last Airbender (ATLA) and Avatar: Legend of Korra (LOK), and asks how it came to be and how stance is conveyed through them. After acknowledging the impact of the series, conceptual blending theory is adopted to investigate the worldbuilding of the macrocosm in ATLA. This is identified as a correlative network, which acts as the blended space of multiple input spaces consisting of intertextual references. The world of ATLA then functions as a new input space which is updated with modern elements, resulting in the blend of LOK. Minor blends are identified in the hybrid animals that occupy the fictional world. Lastly, it is shown how the selection of a particular input element for participation in meme blends already conveys an ideological stance, rather than only emerging through readers’ eyes.
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/xka9m/" target="_blank">The blending of bending: how we engage with the world of Avatar: The Last Airbender through memes</a>
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<li><strong>Legal hunting for conservation of highly threatened species: The case of African rhinos</strong> -
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Legal hunting of highly threatened species – and especially the recreational practice of ‘trophy hunting’ – is controversial with selected ethical objections being increasingly voiced. Less attention has been paid to how hunting (even of threatened species) can be useful as a conservation tool, and likely outcomes if this was stopped. As case studies, we examine the regulated legal hunting in South Africa and Namibia of two African rhino species. Counter-intuitively, removing a small number of specific males can enhance population demography and genetic diversity, encourage range expansion, and generate meaningful socio-economic benefits to help fund effective conservation (facilitated by appropriate local institutional arrangements). Legal hunting of these species has been sustainable, as very small proportions of the populations of both species are hunted each year, and numbers of both today are higher in these countries than when controlled recreational hunting began. Terminating this management option and funding source could have negative consequences at a time when rhinos are being increasingly viewed as liabilities and COVID-19 has significantly impacted revenue generation for wildlife areas. Provided that there is appropriate governance and management, conservation of certain highly threatened species can be supported by cautiously selective and limited legal hunting.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/q79pc/" target="_blank">Legal hunting for conservation of highly threatened species: The case of African rhinos</a>
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<li><strong>Human complement Factor H and Properdin act as soluble pattern recognition receptors and differentially modulate SARS-CoV-2 Infection</strong> -
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Severe cases of SARS-CoV-2 infection are characterised by an imbalanced immune response, excessive inflammation, and the development of acute respiratory distress syndrome, which can lead to multiorgan failure and death. Several studies have demonstrated dysregulated complement activity as an indicator of immunopathogenesis in the SARS-CoV-2 infection. Notably, the complement alternative pathway has been implicated in driving the excessive inflammation during severe SARS-CoV-2 infection. Reduced levels of factor H (FH), a down-regulator of the alternative pathway, and increased levels of properdin (Factor P/FP), the only known up-regulator of the alternative pathway, have been observed in individuals with severe COVID-19 infection. The present study investigated the complement activation-independent, and a more direct role of FH and FP against SARS-CoV-2 infection. Using direct ELISA, the interactions of FH and FP with the SARS-CoV-2 spike (S) and receptor binding domain (RBD) were assessed. Using S protein expressing lentiviral pseudotypes, the cell binding and luciferase-based virus entry assays were employed to assess the potential modulatory effects of FH, FP, and recombinant thrombospondin repeats 4 and 5 (TSR4+5) on SARS-CoV-2 cell entry. We also evaluated the immunomodulatory functions of FH and FP in the cytokine response triggered by SARS-CoV-2 pseudotypes via RT-qPCR. SARS-CoV-2 S and RBD proteins were found to bind both FH and FP. Treatment of A549 cells expressing human ACE2 and TMPRSS2 with FP or TSR4+5 resulted in increased cell entry and binding of SARS-CoV-2 pseudotypes. In silico studies revealed that FP increases affinity between SARS-CoV-2 and host ACE2. The impact of FP on viral cell entry and binding was reversed by anti-FP antibody treatment in A549-hACE2+TMPRSS2 cells. However, FH treatment reduced the cell entry and binding of SARS-CoV-2 lentiviral pseudotypes. Furthermore, the A549-hACE2+TMPRSS2 cells challenged with SARS-CoV-2 spike, envelope, nucleoprotein, and membrane protein expressing alphaviral pseudotypes pre-treated with FP or TSR4+5, exhibited upregulation of the transcripts of pro-inflammatory cytokines, such as IL-1{beta}, IL-8, IL-6, TNF-, IFN- and RANTES (as well as NF-kB). Conversely, FH pre-treatment downregulated the expression of these pro-inflammatory cytokines. Treatment of A549-hACE2+TMPRSS2 cells with FP increased S protein-mediated NF-kB activation, while FH treatment reduced it. These findings suggest that FH may act as an inhibitor of SARS-CoV-2 cell entry and binding, thereby attenuating the infection-associated inflammatory response in a complement activation-independent manner. FP may contribute to viral cell entry, binding, and exacerbating the immune response. That may result in potentially influencing the severity of the infection.
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</div>
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<div class="article-link article-html-link">
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.07.07.548083v1" target="_blank">Human complement Factor H and Properdin act as soluble pattern recognition receptors and differentially modulate SARS-CoV-2 Infection</a>
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<li><strong>Explaining viral pandemics with help from Theology and Physics - Alternative Hypotheses.</strong> -
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Pathogens have been plaguing humans since time immemorial. One characteristic feature is repetition of pandemics by the same pathogen(s) resulting in devastation. However, starting CE 1880, the offending pathogens have been different with every episode. Borrowing concepts from theology and physics, this article tries to proffer answers to some aspects observed regarding Viruses, Vectors, and Humans, and thereby tries to redefine our thinking on the concepts of viral infections. These aspects being: how pandemics occur in the first instance, the rapid global spread of the current Covid-19 Pandemic and will the humanity be able to control such pandemics in future.
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🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/vn8fa/" target="_blank">Explaining viral pandemics with help from Theology and Physics - Alternative Hypotheses.</a>
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<li><strong>Neuron- and microglia-specific immunoexpression in steroid-independent male sexual behaviour in castrated B6D2F1 male mice</strong> -
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<div>
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Sexual behaviour is necessary for procreation for several species and is traditionally viewed to be regulated by sex steroid hormones. However, several species exhibit steroid-independent sexual behaviour, and its molecular understanding is only beginning to be uncovered. The main goal of our experiment was to provide new insight into cell-specific roles that both neuronal and non-neuronal cells may play in steroid-independent male sexual behaviour. Forty B6D2F1 hybrid male mice underwent orchidectomy and were tested for reinstatement of steroid-independent male sexual behaviour after an extended period of social isolation caused by the COVID-19-mandated laboratory shutdown. After 62 weeks post-orchidectomy, 20.59% demonstrated reinstatement of steroid-independent male sexual behaviour (identified as steroid-independent persistent maters), while 23.53% of the males did not display steroid-independent male sexual behaviour (identified as steroid-independent non-maters). Using flow cytometry, we compared the preoptic area immunoexpression in NeuN+ neurons and Iba1+ microglia between steroid-independent persistent maters and steroid-independent non-maters (N = 5-6 per group). We found neuronal immunoexpression up-regulated for amyloid precursor protein and androgen receptor, as well as down-regulated for glucocorticoid receptor in steroid-independent persistent maters compared to steroid-independent non-maters. In conjunction, microglial immunoexpression of amyloid precursor protein was up-regulated in steroid-independent persistent maters compared to steroid-independent non-maters. These data suggest there are cell-specific immunoexpression differences, including the role of non-neuronal cells in steroid-independent male sexual behaviour.
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🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.12.08.519640v3" target="_blank">Neuron- and microglia-specific immunoexpression in steroid-independent male sexual behaviour in castrated B6D2F1 male mice</a>
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<li><strong>Comparative Reconstruction of SARS-CoV-2 transmission in three African countries using a mathematical model integrating immunity data.</strong> -
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Objectives: Africa has experienced fewer coronavirus disease 2019 (COVID-19) cases and deaths than other regions, with a contrasting epidemiological situation between countries, raising questions regarding the determinants of disease spread in Africa. Method: We built a susceptible-exposed-infected-recovered model including COVID-19 mortality data where recovery class is structured by specific immunization and modeled by a partial differential equation considering the opposed effects of immunity decline and immunization. This model was applied to Tunisia, Senegal, and Madagascar. Finding: Senegal and Tunisia experienced two epidemic phases. Initially, infections emerged in naive individuals and were limited by social distancing. Variants of concern (VOCs) were also introduced. The second phase was characterized by successive epidemic waves driven by new VOCs that escaped host immunity. Meanwhile, Madagascar demonstrated a different profile, characterized by longer intervals between epidemic waves, increasing the pool of susceptible individuals who had lost their protective immunity. The impact of vaccination in Tunisia and Senegal on model parameters was evaluated. Interpretation: Loss of immunity and vaccination-induced immunity have played crucial role in controlling the African pandemic. Severe acute respiratory syndrome coronavirus 2 has become endemic now and will continue to circulate in African populations. However, previous infections provide significant protection against severe diseases, thus providing a basis for future vaccination strategies.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.07.07.23292215v1" target="_blank">Comparative Reconstruction of SARS-CoV-2 transmission in three African countries using a mathematical model integrating immunity data.</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Homologous Booster Study of COVID-19 Protein Subunit Recombinant Vaccine</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Biological: SARS-CoV-2 Subunit Recombinant Protein Vaccine<br/><b>Sponsor</b>: PT Bio Farma<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Role of Ivermectin and Colchicine in Treatment of COVID-19: Randomized Controlled Clinical Trial</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Drug: Ivermectin Tablets; Drug: Colchicine 0.5 MG; Drug: Standared managment<br/><b>Sponsor</b>: Ain Shams University<br/><b>Completed</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Immunogenicity and Safety of A Recombinant Protein COVID-19 Vaccine as Booster Vaccines</strong> - <b>Conditions</b>: COVID-19; SARS-CoV-2 Infection<br/><b>Interventions</b>: Biological: SCTV01E-2; Biological: SCTV01E<br/><b>Sponsor</b>: Sinocelltech Ltd.<br/><b>Not yet recruiting</b></p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Vaccine Hesitancy Counseling Intervention for Pharmacists</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Behavioral: Standard implementation webinar and online training; Behavioral: Virtual facilitation<br/><b>Sponsors</b>: University of North Carolina, Chapel Hill; University of Arkansas; University of South Carolina; National Institute on Minority Health and Health Disparities (NIMHD)<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Developing an Effective Intervention to Address Post-Corona-Virus-Disease-2019 Balance Disorders, Weakness and Muscle Fatigue in Individuals Aged 65+</strong> - <b>Condition</b>: COVID-19<br/><b>Intervention</b>: Device: Resistance Training<br/><b>Sponsor</b>: Józef Piłsudski University of Physical Education<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>LUSZ Treatment Efficacy in Hospitalized COVID-19 Patients</strong> - <b>Conditions</b>: COVID-19; Hospitalized COVID-19 Patients<br/><b>Interventions</b>: Drug: Lopinavir / Ritonavir; Drug: Remdesivir (RDV); Drug: Tocilizumab; Other: Corticosteroid Therapy-enhanced Standard Care (CTSC)<br/><b>Sponsors</b>: Lebanese University; Hospital Saydet Zgharta University Medical Center<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Multimodal Long Covid19</strong> - <b>Condition</b>: Long COVID-19 Syndrome<br/><b>Intervention</b>: Other: Multimodal intervention in Long Covid19<br/><b>Sponsors</b>: Universidad de Magallanes; Teaching Assistance and Research Center of the University of Magallanes CADI-UMAG; Clinical Hospital Dr. Lautaro Navarro Avaria<br/><b>Active, not recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comprehensive Imaging Exam of Convalesced COVID-19 Patients</strong> - <b>Conditions</b>: COVID-19; COVID Long-Haul<br/><b>Interventions</b>: Other: Magnetic Resonance Imaging; Other: Ultra-High Resolution Computed Tomography (CT) Scan<br/><b>Sponsors</b>: Johns Hopkins University; Canon Medical Systems, USA<br/><b>Enrolling by invitation</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UNAIR Inactivated COVID-19 Vaccine as Heterologue Booster (Immunobridging Study)</strong> - <b>Conditions</b>: COVID-19 Pandemic; COVID-19 Vaccines<br/><b>Interventions</b>: Biological: Vaksin Merah Putih - UA SARS-CoV-2 (Vero Cell Inactivated) 5 µg; Biological: CoronaVac Biofarma COVID-1 9 Vaccine 3 µg<br/><b>Sponsors</b>: Dr. Soetomo General Hospital; Indonesia-MoH; Universitas Airlangga; Biotis Pharmaceuticals, Indonesia<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety Study of SCB-2023 Vaccine as a Booster in Adults</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: SCB-2023 vaccine (trivalent), a recombinant SARS-CoV-2 trimeric S-protein subunit vaccine for COVID-19; intramuscular injection; Biological: SCB-2019 (monovalent), a recombinant SARS-CoV-2 trimeric S-protein subunit vaccine for COVID-19; intramuscular injection<br/><b>Sponsor</b>: Clover Biopharmaceuticals AUS Pty Ltd<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Safety and Immunogenicity Following a Heterologous Booster Dose of Recombinant SARS-CoV-2 Vaccine LYB002</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: LYB002V14; Biological: LYB002V14A; Biological: LYB002CA<br/><b>Sponsors</b>: Guangzhou Patronus Biotech Co., Ltd.; Yantai Patronus Biotech Co., Ltd.; Affiliated Hospital of North Sichuan Medical College<br/><b>Active, not recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase 2/3 Heterologous Boosting Study With Different Dose Levels of Monovalent SARS-CoV-2 rS Vaccines</strong> - <b>Condition</b>: COVID-19<br/><b>Interventions</b>: Biological: NVX-CoV2373 (5μg); Biological: NVX-CoV2601 (5μg); Biological: NVX-CoV2601(5μg); Biological: NVX-CoV2601 (35μg); Biological: NVX-CoV2601(35μg); Biological: NVX-CoV2601(50μg); Biological: Bivalent BA.4/5<br/><b>Sponsor</b>: Novavax<br/><b>Not yet recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney Disease</strong> - <b>Conditions</b>: COVID-19; Renal Insufficiency, Chronic<br/><b>Intervention</b>: Drug: Nirmatrelvir/ritonavir<br/><b>Sponsor</b>: Chinese PLA General Hospital<br/><b>Recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Immunogenicity and Safety Following a Heterologous Booster Dose of Recombinant SARS-CoV-2 Vaccine LYB001</strong> - <b>Conditions</b>: COVID-19; Vaccine Reaction<br/><b>Interventions</b>: Biological: LYB001; Biological: CoronaVac<br/><b>Sponsors</b>: Guangzhou Patronus Biotech Co., Ltd.; Yantai Patronus Biotech Co., Ltd.; Affiliated Hospital of North Sichuan Medical College<br/><b>Active, not recruiting</b></p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Anakinra Treatment for Patients With Post Acute Covid Syndrome</strong> - <b>Condition</b>: Post-Acute COVID-19 Syndrome<br/><b>Interventions</b>: Drug: Placebo; Drug: Anakinra 149 MG/ML Prefilled Syringe [Kineret]<br/><b>Sponsor</b>: Hellenic Institute for the Study of Sepsis<br/><b>Not yet recruiting</b></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro</strong> - Introduction: The identification of chemical compounds that interfere with SARS-CoV-2 replication continues to be a priority in several academic and pharmaceutical laboratories. Computational tools and approaches have the power to integrate, process and analyze multiple data in a short time. However, these initiatives may yield unrealistic results if the applied models are not inferred from reliable data and the resulting predictions are not confirmed by experimental evidence. Methods: We…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Virtual high-throughput screening: Potential inhibitors targeting aminopeptidase N (CD13) and PIKfyve for SARS-CoV-2</strong> - Since the outbreak of the novel coronavirus nearly 3 years ago, the world’s public health has been under constant threat. At the same time, people’s travel and social interaction have also been greatly affected. The study focused on the potential host targets of SARS-CoV-2, CD13, and PIKfyve, which may be involved in viral infection and the viral/cell membrane fusion stage of SARS-CoV-2 in humans. In this study, electronic virtual high-throughput screening for CD13 and PIKfyve was conducted…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats</strong> - Favipiravir is a nucleoside analogue antiviral drug and inhibits the replication of many RNA viruses, especially influenza viruses. Favipiravir has also been used to treat patients with mild to moderate COVID-19 disease. However, various side effects, including neurological side effects, have been reported related to the use of favipiravir. Therefore, in this study, we aimed to investigate the possible effects of favipiravir alone or in combination with vitamin C on aged rats’ brain tissue and…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong><em>In silico</em> identification of D449-0032 compound as a putative SARS-CoV-2 M<sup>pro</sup> inhibitor</strong> - The SARS-CoV-2 pandemic originated the urgency in developing therapeutic resources for the treatment of COVID-19. Despite the current availability of vaccines and some antivirals, the occurence of severe cases of the disease and the risk of the emergence of new virus variants still motivate research in this field. In this context, this study aimed at the computational prospection of likely inhibitors of the main protease (M^(pro)) of SARS-CoV-2 since inhibiting this enzyme leads to disruption of…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synthesis of multivalent sialyllactose-conjugated PAMAM dendrimers: Binding to SARS-CoV-2 spike protein and influenza hemagglutinin</strong> - Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) and influenza viruses have spread around the world at an unprecedented rate. Despite multiple vaccines, new variants of SARS-CoV-2 and influenza have caused a remarkable level of pathogenesis. The development of effective antiviral drugs to treat SARS-CoV-2 and influenza remains a high priority. Inhibiting viral cell surface attachment represents an early and efficient means to block virus infection. Sialyl glycoconjugates, on…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nanobodies with cross-neutralizing activity provide prominent therapeutic efficacy in mild and severe COVID-19 rodent models</strong> - The weakened protective efficacy of COVID-19 vaccines and antibodies caused by SARS-CoV-2 variants presents a global health emergency, which underscores the urgent need for universal therapeutic antibody intervention for clinical patients. Here, we screened three alpacas-derived nanobodies (Nbs) with neutralizing activity from twenty RBD-specific Nbs. The three Nbs were fused with the Fc domain of human IgG, namely aVHH-11-Fc, aVHH-13-Fc and aVHH-14-Fc, which could specifically bind RBD protein…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Janus kinase inhibition in juvenile idiopathic arthritis</strong> - No abstract</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2</strong> - CONCLUSIONS: This study demonstrates direct inhibition of the SARS-CoV-2 E protein by classical viroporin inhibitors. Ivermectin and milbemycin inhibit the E protein channel but their cytotoxicity argues against clinical application.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structural basis for the inhibition of coronaviral main proteases by ensitrelvir</strong> - Main protease (M^(pro)) is a highly conserved cysteine protease that plays a vital role in the replication of coronaviruses, making it an attractive pan-coronaviral therapeutic target. Ensitrelvir (S-217622), developed by Shionogi, is the first orally active non-covalent, non-peptidic SARS-CoV-2 M^(pro) inhibitor, which also displays antiviral efficacy against other human coronaviruses as well as SARS-CoV-2 variants of concern (VOCs) and variants of interest (VOIs). Here, we report the crystal…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion</strong> - CONCLUSIONS: Kae prevents SARS-CoV-2 infection by blocking membrane fusion and possesses a broad-spectrum anti-fusion ability. These findings provide valuable insights into potential benefits of Kae-containing botanical products as a complementary prophylaxis, especially during the waves of breakthrough infections and re-infections.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prologue: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2022 Annual Meeting</strong> - The 2022 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) was held from July 14 to 17, 2022, in New York City, New York, USA, and was attended by 420 rheumatologists, dermatologists, basic scientists, allied health professionals, patient research partners, and industry partners from 31 countries. A GRAPPA executive retreat, a Trainee Symposium, and the Patient Research Partners Network meeting were held prior to the annual meeting….</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NETosis promotes chronic inflammation and fibrosis in systemic lupus erythematosus and COVID-19</strong> - Pulmonary fibrosis, a serious complication of systemic lupus erythematosus (SLE) and coronavirus disease 2019 (COVID-19), leads to irreversible lung damage. However, the underlying mechanism of this condition remains unclear. In this study, we revealed the landscape of transcriptional changes in lung biopsies from individuals with SLE, COVID-19-induced pulmonary fibrosis, and idiopathic pulmonary fibrosis (IPF) using histopathology and RNA sequencing, respectively. Despite the diverse etiologies…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes</strong> - The evolving SARS-CoV-2 Omicron strain has repeatedly caused widespread disease epidemics, and effective antibody drugs continue to be in short supply. Here, we identified a batch of nanobodies with high affinity for receptor binding domain (RBD) of SARS-CoV-2 spike protein, separated them into three classes using high performance liquid chromatography (HPLC), and then resolved the crystal structures of the ternary complexes of two non-competing nanobodies (NB1C6 and NB1B5) with RBD using X-ray…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Repurposing the Medicines for Malaria Venture’s COVID Box to discover potent inhibitors of Toxoplasma gondii, and in vivo efficacy evaluation of almitrine bismesylate (MMV1804175) in chronically infected mice</strong> - Toxoplasmosis, caused by the obligate intracellular parasite Toxoplasma gondii, affects about one-third of the world’s population and can cause severe congenital, neurological and ocular issues. Current treatment options are limited, and there are no human vaccines available to prevent transmission. Drug repurposing has been effective in identifying anti-T. gondii drugs. In this study, the screening of the COVID Box, a compilation of 160 compounds provided by the “Medicines for Malaria Venture”…</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting 2-Oxoglutarate-Dependent Dioxygenases Promotes Metabolic Reprogramming That Protects against Lethal SARS-CoV-2 Infection in the K18-hACE2 Transgenic Mouse Model</strong> - Dysregulation of host metabolism is a feature of lethal SARS-CoV-2 infection. Perturbations in α-ketoglutarate levels can elicit metabolic reprogramming through 2-oxoglutarate-dependent dioxygenases (2-ODDGs), leading to stabilization of the transcription factor HIF-1α. HIF1-α activation has been reported to promote antiviral mechanisms against SARS-CoV-2 through direct regulation of ACE2 expression (a receptor required for viral entry). However, given the numerous pathways HIF-1α serves to…</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
|
||||
|
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
|
||||
<li><a href="#from-new-yorker">From New Yorker</a></li>
|
||||
<li><a href="#from-vox">From Vox</a></li>
|
||||
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
|
||||
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
|
||||
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
|
||||
<li><a href="#from-ars-technica">From Ars Technica</a></li>
|
||||
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What to Do with Climate Emotions</strong> - If the goal is to insure that the planet remains habitable, what is the right degree of panic, and how do you bear it? - <a href="https://www.newyorker.com/news/annals-of-a-warming-planet/what-to-do-with-climate-emotions">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wes Moore Would Like to Make History</strong> - Maryland’s first Black governor talks about his surprise win, what working in banking taught him about power, his grandmother’s advice, and the importance of service. - <a href="https://www.newyorker.com/news/the-new-yorker-interview/wes-moore-would-like-to-make-history">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Alternative Facts of Robert F. Kennedy, Jr.</strong> - The Democratic Presidential candidate talks about his right-wing admirers, his distrust of scientists and the media, and his belief that the C.I.A. was involved in J.F.K.’s death. - <a href="https://www.newyorker.com/news/q-and-a/the-alternative-facts-of-robert-f-kennedy-jr">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Conspiracies of Robert F. Kennedy, Jr.</strong> - The anti-vaccine activist and litigator with a famous name and a long history of addiction has decided to run for President. David Remnick probes what his candidacy is all about. - <a href="https://www.newyorker.com/podcast/the-new-yorker-radio-hour/the-conspiracies-of-robert-f-kennedy-jr">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>To Save the Planet, Should We Really Be Moving Slower?</strong> - The degrowth movement makes a comeback. - <a href="https://www.newyorker.com/news/daily-comment/to-save-the-planet-should-we-really-be-moving-slower">link</a></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
|
||||
<ul>
|
||||
<li><strong>What 1,000 years of history can teach us about making the economy of AI work for everyone</strong> -
|
||||
<figure>
|
||||
<img alt="A smart factory with an engineer controlling robotic arms through superimposed digital screens." src="https://cdn.vox-cdn.com/thumbor/zbSEn0-H41z_iO0EwTQHGb3ZZus=/804x0:5632x3621/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72439277/GettyImages_1441659037.0.jpg"/>
|
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<figcaption>
|
||||
Getty Images
|
||||
</figcaption>
|
||||
</figure>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Two economists on why progress requires more than technological innovation alone
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h7W8p3">
|
||||
It’s tempting to imagine <a href="https://www.theatlantic.com/science/archive/2019/07/we-need-new-science-progress/594946/">progress strictly as a technological science</a>, where both its history and future are stories of humanity becoming more prosperous one major innovation at a time. But that would be a mistake, according to MIT economists Daron Acemoglu and Simon Johnson in their new book, <a href="https://www.hachettebookgroup.com/titles/daron-acemoglu/power-and-progress/9781541702530/?lens=publicaffairs"><em>Power and Progress: Our 1000-Year Struggle Over Technology & Prosperity</em></a><em>.</em>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g0a3Sd">
|
||||
The book traverses a millennium of disruptive technologies, from medieval agriculture and ship design all the way up to the foothills of <a href="https://www.vox.com/2023/4/28/23702644/artificial-intelligence-machine-learning-technology">generative AI</a>. Along the way, they argue that innovation has proven just as likely to cause misery as it has prosperity. On their list of examples is the cotton gin, which turned the United States into the world’s largest cotton exporter, while also deepening a system of enslavement that spread across the American South. When prosperity <em>does</em> win out, it’s usually because citizens organized to demand more equitable arrangements than those enriching a narrow elite.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jzXuDX">
|
||||
“A thousand years of history and contemporary evidence make one thing abundantly clear: there is nothing automatic about new technologies bringing widespread prosperity. Whether they do or not is an economic, social, and political choice,” they write.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qy2wdf">
|
||||
They are no more sanguine about the future of the next great innovation: AI. In their view, translating innovation around AI into shared prosperity will require countervailing powers, like a labor movement demanding worker-friendly automation, and a civil society movement upholding a more egalitarian vision for the kind of society AI can help create.
|
||||
</p>
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||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OlANN4">
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||||
“We’re addressing the core problem that no one else has talked about: It’s about the vision that drives how you imagine the future,” Johnson told me. “And a lot of our argumentation and policy proposals are designed to help people understand how easy it would be to change that vision.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hlucoM">
|
||||
I spoke with Acemoglu and Johnson about what choices steered innovation toward progress in the past, and what specific <a href="https://www.vox.com/policy">policies</a> their trek through history suggests we might consider today. A transcript, edited for length and clarity, follows.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="p87MLe">
|
||||
<strong>Your book argues that technological progress, alone, does not automatically lead to shared prosperity. What else is necessary to turn innovation toward the common good?</strong>
|
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RNoykV">
|
||||
<strong>Daron Acemoglu: </strong>The first key ingredient that we argue for technological advances translating into something resembling shared progress is that their direction should not be just automation, or sidelining humans. That’s critical for keeping humans in the loop and increasing their contribution to production, and an institutional structure that enables them to actually get the returns out of that. And second, vision, which is critical, because we argue there’s nothing inevitable about any of those things. Both technologies and institutions are shaped by the visions of powerful actors as well as other political balances.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rAdYTe">
|
||||
<strong>You focus on “vision” throughout the book, but it’s sort of a nebulous idea. Are there any historical examples that show how much of an impact guiding visions can have?</strong>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c9Yrt1">
|
||||
<strong>Simon Johnson: </strong>The reason we start in the medieval period is because we’re quite convinced that the so-called Dark Ages were not particularly dark from the point of view of creativity and innovation. From 1,000 years ago, they were actually very creative, with lots of inventions across agriculture and commerce. But the prevailing vision of that medieval period was one where you had a small elite who argued that they had a divinely endowed power, and took pretty much all the proceeds of that higher productivity and put them into monumental cathedrals.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8O1qJ4">
|
||||
Those cathedrals <a href="https://eml.berkeley.edu/~jsteinsson/papers/malthus.pdf">did not increase productivity</a>; they didn’t improve <a href="https://www.vox.com/public-health">public health</a>. They were <a href="https://academic.oup.com/past/article-abstract/70/1/30/1417447">symbols of oppression</a>. You can argue that it was an alternative vision breaking away from that medieval, religious-oriented, top-down control vision that was necessary, though not sufficient, for the beginnings of the modern era and industrialization.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZqAVsQ">
|
||||
<strong>What struck me about your chapter on the Industrial Revolution was the huge gap between the introduction of new technologies and the beginnings of anything that resembled shared prosperity. You argue that for the better part of a century, many people’s lives just became more miserable.</strong>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TyqC0R">
|
||||
<strong>Simon Johnson: </strong>You can argue about when exactly the Industrial Revolution got started. I like the 1720s because that’s when the first big silk mill was built just outside Derby [an English city]. That began putting people into factories with machines that were controlled by an employer. So the 1720s is a good starting point.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s9jbgC">
|
||||
Young children were working 18 hours a day pushing coal carts with their heads deep underground. We know that was happening in the 1840s because that was a matter of investigation by royal commission. Because it wasn’t illegal, everyone involved was quite candid about it, and said, “Look, that’s what you need in order for a coal industry to exist.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xZNrqO">
|
||||
So that’s 120 years where you cannot say that these 6-year-old children were living better. Some people argue a little about wages, but living conditions and public health in those cities were dreadful. And after the 1840s, there was a shift in thinking. It wasn’t particularly altruistic, it was more “My god, we have <a href="https://www.vox.com/infectious-disease">infectious disease</a> rampant in Manchester because there’s no toilets. What are we going to do about it?” Consequently, there was a reimagining of how technology could be applied, including the modern sanitation movement, which was by far the No. 1 breakthrough in the use of technology in the 19th century. And this coincides with trade <a href="https://www.vox.com/unions">unions</a> beginning to get organized and pressure on the political elite to allow wages to rise.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dHFOBJ">
|
||||
So if I said to you that generative AI is here, and that you and your families will be better off in 120 years, I think people should be fairly unsatisfied with that. Why do we have to wait so long?
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0xv0yt">
|
||||
<strong>Daron Acemoglu: </strong>It’s sort of remarkable how consistent this view is among many economists, policymakers, and even the Democratic Party: when you have better technologies, the costs are “transitional.” What that encapsulates is that there’s often an implicit belief that [shared prosperity] is automatic, but it might take time.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tjzTdQ">
|
||||
The biggest target for Simon and I is that there is nothing automatic about it. But the automatic view gives you a real sense of comfort. Wealth inequality may be horrible, democracy may be in a difficult position today, generative AI may create lots of disruptions, but we’ll work it out.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wK0ZyS">
|
||||
<strong>So if there was nothing automatic about that long period of industrial-born misery eventually turning into shared prosperity, why </strong><em><strong>did</strong></em><strong> it eventually begin to shift for the better?</strong>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XV9AdC">
|
||||
<strong>Daron Acemoglu:</strong> Cities and factories created huge amounts of misery, but they also changed how easy it was for people to organize. Once hundreds of thousands of working people were concentrated in cities and workplaces, the demand for representation grew difficult to turn down.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kvcjmz">
|
||||
But there were other factors, like the redirection of technological change. The next phase of industrial technology in heavy industry like chemicals and steel opened up new opportunities for investing in human skills. American technologies had to prioritize making unskilled workers more productive, and once that got started it spread around the world.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E6TqiO">
|
||||
<strong>You make a distinction between two kinds of automation. One, “so-so automation,” just replaces workers outright. The other, “machine usefulness,” either complements their skills or creates new tasks for workers. You argue that we should aim for the latter — what’s an example?</strong>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Q3Shtp">
|
||||
<strong>Simon Johnson: </strong>The central example is when Ford comes to Detroit and takes on car production. In 1900, the US car industry produced about 3,500 cars a year, mostly artisanal. Henry Ford put car production on the assembly line and increased productivity more than 100-fold. He also, of course, automated many of the <a href="https://www.vox.com/labor-jobs">jobs</a> that had previously been done by those artisans. However, what he did, along with the managers and engineers and suppliers and consumers, was create this enormous industry. By the end of the 1920s, the US was making between 2 and 3 million cars a year, employing 400,000 people. Most of those people had tasks, which led to jobs that had never been done by any human ever. And by the way, unions became stronger and pushed for wages.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VR7BI7">
|
||||
So we are in no way opposed to automation. We are encouraging the seeking out and development of those human-complementary innovations and uses of machines, because it’s that increased demand for labor that is the heart of high wages and shared prosperity.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RUQK0S">
|
||||
<strong>Labor movements and unions were the basis of those countervailing social powers in 19th-century America. Today, despite some high-profile media organizing and strike waves, </strong><a href="https://www.vox.com/future-perfect/2023/6/10/23754360/labor-union-resurgence-boom-starbucks-amazon-sectoral-bargaining"><strong>union membership remains at an all-time low in the US</strong></a><strong>. What role do you see for the labor movement going forward?</strong>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zmSCRp">
|
||||
<strong>Daron Acemoglu: </strong>The future of the labor movement is open. We are convinced you need workers’ voice. It’s not good when AI regulation is discussed by senators and the CEOs of the chief tech companies and nobody else. And there are many things that are wrong. Sectoral unions would be better [than individual workplace unions, as is common in the US], but you might need a broader civil society movement to complement the labor movement, and the labor movement itself needs to find new organizational forms.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="70EdL8">
|
||||
<strong>You surveyed 1,000 years of history in order to argue that AI will not automatically lead to shared prosperity and that we’ll need specific policy interventions to achieve that. Could you each share one policy that you’ve come to believe should be a part of that debate?</strong>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hhWNeV">
|
||||
<strong>Daron Acemoglu:</strong> One that I will put on the table is evening out the taxation of labor and capital. Our tax code creates artificial incentives for firms to use capital instead of labor. You can have bipartisan support if it’s presented the right way: not taxing businesses more, but trying to create more opportunities for labor. Corporate income taxes would be one channel. But first, I would start with removing some of the most aggressive <a href="https://www.brookings.edu/articles/does-the-u-s-tax-code-favor-automation/">depreciation allowances</a> [a tax deduction that allows businesses to recover the annual cost of property or equipment use] which essentially enable firms to <a href="https://www.nber.org/papers/w27052">write off a lot of their digital and equipment investments</a>.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dCalVG">
|
||||
<strong>Simon Johnson:</strong> I’ll suggest two. One is surveillance. In the case of employment, if surveillance actually makes your life more stressful, and makes you more likely to cause an accident or injure yourself, that is something that falls within the sphere of reasonable regulation. We should consider negotiating safeguards on surveillance across G7 allies and other industrial democracies.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MpgHsV">
|
||||
The second one is: Show me the new tasks. How do we get more invention in that direction? We know how to do this; we’ve seen it many times since 1940 in the United States. You put some federal government money in.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B8Efyh">
|
||||
The interesting thing about federal money is that it’s catalytic; you don’t have to put that much money in. If you look at the Human Genome Project, for example, which was turned down by venture capitalists in the 1980s because they said, “Hey, great idea, but we don’t know how to benefit from it because it will be general knowledge,” it became a government-funded project. It cost about $10 billion, creating an industry that employed 200,000 people, and changed the world repeatedly. So federal money applied in this strategic, purposeful manner, can change everything.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9fAYuO">
|
||||
<em>Their book, </em><a href="https://www.hachettebookgroup.com/titles/daron-acemoglu/power-and-progress/9781541702530/?lens=publicaffairs"><em>Power and Progress: Our 1000-Year Struggle Over Technology & Prosperity</em></a><em>, is available now.</em>
|
||||
</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How to travel now</strong> -
|
||||
<figure>
|
||||
<img alt="A bright illustration centered on the word “Now.” The O is a compass, while stars and exclamation points decorate the top." src="https://cdn.vox-cdn.com/thumbor/ICqzdGfUTXfwmUxc5cFnRtYEWOQ=/149x0:1589x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72434285/Travel_now_cover.0.jpg"/>
|
||||
<figcaption>
|
||||
Dion Lee/Vox; Getty Images
|
||||
</figcaption>
|
||||
</figure>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The Vox guide to navigating the world, the country, and your own backyard.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4TSMZt">
|
||||
After three years of pandemic life, travel is back in a big way this summer.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WY1HEp">
|
||||
More people are taking trips this summer after putting plans on hold, but climate change, social media-fueled overcrowding, rising costs, and other factors have converged to make travel decisions more fraught than ever. For Vox’s first-ever travel guide, we wanted to answer some of your most pressing questions about travel now, from how to navigate the many decisions and ethical dilemmas around traveling, to explaining why our travel and transportation systems are designed the way they are.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zZDcPK">
|
||||
Each week throughout July, we’ll be publishing new articles and videos answering your biggest travel questions. Stay tuned for more! <em>— Nisha Chittal, managing editor</em>
|
||||
</p>
|
||||
<hr class="p-entry-hr" id="wFBW0i"/>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JxJVnU">
|
||||
<small><strong>CREDITS</strong></small>
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XozT0q">
|
||||
<small><em><strong>Managing editor: </strong></em></small><small><em>Nisha Chittal | </em></small><small><em><strong>Editors:</strong></em></small><small><em> Alanna Okun, Izzie Ramirez, Marina Bolotnikova, Meredith Haggerty, Bryan Walsh | </em></small><small><em><strong>Contributors: </strong></em></small><small><em>Allie Volpe, Kenny Torrella, Rebecca Jennings, Emily Stewart, Julieta Cardenas, Carlye Wisel, Paulette Perhach | </em></small><small><em><strong>Art Director: </strong></em></small><small><em>Paige Vickers | </em></small><small><em><strong>Illustrations:</strong></em></small><small><em> Naomi Elliott | </em></small><small><em><strong>Style & Standards: </strong></em></small><small><em>Tanya Pai, Caity PenzeyMoog, Kim Eggleston, Elizabeth Crane, Sarah Schweppe | </em></small><small><em><strong>Video:</strong></em></small><small><em> Adam Freelander, Bridgett Henwood, Cath Spangler, Christophe Haubursin, Coleman Lowndes, Edward Vega, Joey Sendaydiego, Kim Mas, Kristen Williamson, Laura Bult, Liz Scheltens, Matt Dunne, Mona Lalwani, Valerie Lapinski, Dean Peterson, Estelle Caswell | </em></small><small><em><strong>Audience:</strong></em></small><small><em> Gabby Fernandez, Jayne A. Quan</em></small>
|
||||
</p></li>
|
||||
<li><strong>Why do RVs have these ugly swoops?</strong> -
|
||||
<figure>
|
||||
<img alt="" src="https://cdn.vox-cdn.com/thumbor/qQRDczbZurWv4I6KMT_HXx3MkNQ=/240x0:1680x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72439119/VDC_VBD_015_THUMB_SYN.0.jpg"/>
|
||||
</figure>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
This swoopy, swishy paint job defines the RV aesthetic.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Ck7NO">
|
||||
You’ve seen it on the highway: a giant RV, lumbering by with its exterior totally covered in swishes and swoops. Those swoopy lines of paint seem to grace the sides of every recreational vehicle, and for decades they’ve defined the RV aesthetic. But where did they come from?
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8Ho2wf">
|
||||
In this video, producer Estelle Caswell heads to Elkhart, Indiana — the global capital of RV production — to investigate why these swoops are everywhere, and whether they’re here to stay. While there, she explores Elkhart’s RV history museum and library, and speaks to RV designers who love and hate the swoops.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1hWlam">
|
||||
Will RV makers be forced to change their infamous look to appeal to younger generations obsessed with clean aesthetics? Or are we stuck with this look for the next 20 years? Check out the video to find out.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9aPuzJ">
|
||||
This video is the first of five in our travel design miniseries. Tune in next week <a href="https://www.youtube.com/channel/UCLXo7UDZvByw2ixzpQCufnA">on our YouTube channel</a> to see why train travel has a bad reputation in the US.
|
||||
</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The upcoming Asian Games will be challenging, says Indian TT player Sreeja Akula</strong> -</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Grand Chess Tour: Carlsen wins; Gukesh finishes 5th, Anand settles for 7th in Blitz event</strong> - Carlsen capped off an incredible blitz performance to win the top prize a score of 26 points out of a possible 36, taking home a first-place prize of $40,000</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Archer Salunkhe is recurve men’s under-21 individual champion</strong> - He was the first Indian male archer to achieve the feat</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia’s Warner in spotlight as Cummins says all options on table</strong> - Australia captain Pat Cummins declined to back Warner’s place in the side for Old Trafford, while saying it would be hard to drop Marsh</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indian shuttler Lakshya Sen wins Canada Open 2023</strong> - The 21-year-old Lakshya Sen triumphed over the reigning All England Champion Li Shi Feng by winning the first set by 21-18 and the second set by 22-20.</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>VHP demands fair and transparent probe into murder of Jain monk</strong> - State government urged to initiate stern action against those involved in the heinous killing and also take steps to enhance the safety and protection of religious leaders</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Defence Minister Rajnath Singh discusses strengthening of bilateral ties with Malaysia’s top leadership</strong> - Rajnath Singh arrived in Kuala Lumpur on a three-day visit to Malaysia on Sunday</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>West Bengal panchayat election | Nadda sets up four member committee to probe poll violence</strong> - Official sources said the delegation will reach the State on July 11 and has been asked to submit its report at the earliest</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watch | Inside the iconic Kannan and Co. Goli Soda factory in Vellore</strong> - Kannan and Co. Goli Soda in Vellore district of Tamil Nadu, is successfully marching towards its 100th year. It is one of the first goli soda businesses in the Madras province in the British era.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Here are the big stories from Karnataka today</strong> - Welcome to the Karnataka Today newsletter, your guide from The Hindu on the major news stories to follow today. Curated and written by The Hindu Bureau.</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
||||
<ul>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Wagner boss Yevgeny Prigozhin met Russia’s Vladimir Putin after mutiny</strong> - The meeting in Moscow took place days after last month’s failed rebellion, the Kremlin says.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Migrant boat from Senegal carrying 200 people missing off Canary Islands</strong> - The aid group Walking Borders says many children are on board the missing boat, which departed from Senegal.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dutch PM Mark Rutte to quit politics after government collapse</strong> - Mark Rutte says he will stand down after fresh elections are held in November.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Poland strengthens Belarus border over Wagner fears</strong> - The prospect of Russian Wagner mercenaries moving to Belarus causes concern across the Polish border.</p></li>
|
||||
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Zelensky honours Poles killed by Ukrainians in WW2 Volhynia massacre</strong> - Ukraine’s leader seeks to heal a deep historical wound with his Polish counterpart at a church service.</p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Probing the mysteries of neutron stars with a surprising earthly analog</strong> - Ultracold gases in the lab could help scientists better understand the universe. - <a href="https://arstechnica.com/?p=1952152">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Guidemaster: PC games to keep the dream alive in a cross-platform world</strong> - Only modest computer hardware is required to play these favorites. - <a href="https://arstechnica.com/?p=1952005">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Threads’ privacy policy compares to Twitter’s (and its rivals’)</strong> - Here’s what is collected by Threads, as well as by Twitter, Bluesky, Mastodon, Spill, and Hive Social. - <a href="https://arstechnica.com/?p=1952168">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In-space manufacturing startup aces pharma experiment in orbit</strong> - One more big test remains for Varda’s first-of-its-kind “space factory.” - <a href="https://arstechnica.com/?p=1952343">link</a></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rare case of green hairy tongue is pure nightmare fuel</strong> - The man fully recovered after extra tongue brushing. But you might not. - <a href="https://arstechnica.com/?p=1952298">link</a></p></li>
|
||||
</ul>
|
||||
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
|
||||
<ul>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A taxi passenger tapped the driver on the shoulder to ask him a question.</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The driver screamed, lost control of the car, nearly hit a bus, went up on the footpath, and stopped inches from a shop window.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
For a second, everything was quiet in the cab. Then the driver said, “Look, mate, don’t ever do that again. You scared the living daylights out of me!”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The passenger apologized and said, “I didn’t realize that a little tap would scare you so much.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
The driver replied, “Sorry, it’s not really your fault. Today is my first day as a cab driver — I’ve been driving a funeral van for the last 25 years.”
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/njman10"> /u/njman10 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14vkwr8/a_taxi_passenger_tapped_the_driver_on_the/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14vkwr8/a_taxi_passenger_tapped_the_driver_on_the/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>At a crowded bus stop, a beautiful young woman in a tight leather mini skirt, with matching tight leather boots and jacket was waiting for the bus..</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
As the bus rolled up and it became her turn to get on, she became aware that her skirt was too tight to allow her leg to come up to the height of the first step on the bus.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Slightly embarrassed and with a quick smile to the bus driver, she reached behind and unzipped her skirt a little, thinking that this would give her enough slack to raise her leg.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Again, she tried to make the step onto the bus, only to discover she still couldn’t!
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
So, a little more embarrassed, she once again reached behind and unzipped her skirt a little more and for a second time attempted the step and once again, still she could not raise her leg because of the tight skirt.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
With a coy little smile to the driver, she again unzipped the offending skirt to give a little more slack and again was unable to make the step.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
About this time, a big Texan that was behind her in the line picked her up easily from the waist and placed her lightly on the step of the bus.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Well, she went ballistic and turned on the would-be hero screeching at him, “How dare you touch my body!! I don’t even know who you are!”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
At this, the Texan drawled, “Well ma’am normally I would agree with you, but after you unzipped my fly three times, I kinda figured that we were friends.”
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/HelpingHandsUs"> /u/HelpingHandsUs </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14v6d18/at_a_crowded_bus_stop_a_beautiful_young_woman_in/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14v6d18/at_a_crowded_bus_stop_a_beautiful_young_woman_in/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Every time when I ask someone what does LGBT stand for,</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
I never get a straight answer.
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Baffit-4100"> /u/Baffit-4100 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14vd1gz/every_time_when_i_ask_someone_what_does_lgbt/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14vd1gz/every_time_when_i_ask_someone_what_does_lgbt/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Professor X is talking to a girl, “what is your mutant power?”</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Girl replies: “I can guess how many pulls to turn a ceiling fan off on the first try!”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
She points up and says: “3 pulls”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Professor X stands up and pulls 3 times. After the third pull the fan turns off.
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Professor X: “Yeah thats cool and all, but not really a super power…”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Girl: “Yeah I was jut kidding, I can heal paraplegics”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
Professor X, still standing: “Oh my god”
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/HelpingHandsUs"> /u/HelpingHandsUs </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14v1qdd/professor_x_is_talking_to_a_girl_what_is_your/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14v1qdd/professor_x_is_talking_to_a_girl_what_is_your/">[comments]</a></span></p></li>
|
||||
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A man enters the confessional</strong> - <!-- SC_OFF --></p>
|
||||
<div class="md">
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
He says to the priest “father, do you know that new girl who moved into town?”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Kathrine? That supermodel with the blonde hair and the long legs?”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“That’s the one father. Well, I’ve been sleeping with her all week. We did it twice a day Monday to Friday, and then on Saturday we did it four times, and then just this morning we did it before I came here.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Oh my, and you’re not married to her?”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“No father.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Well do you at least know if she’s a good catholic?”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“She’s not a catholic at all father and neither am I.”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“Well if you’re not a catholic what are you doing telling me?”
|
||||
</p>
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
||||
“I’m telling everybody in town!”
|
||||
</p>
|
||||
</div>
|
||||
<!-- SC_ON -->
|
||||
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Wolfblood-is-here"> /u/Wolfblood-is-here </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/14vlvqi/a_man_enters_the_confessional/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/14vlvqi/a_man_enters_the_confessional/">[comments]</a></span></p></li>
|
||||
</ul>
|
||||
|
||||
|
||||
<script>AOS.init();</script></body></html>
|
||||
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Reference in New Issue