navan
/
Daily-Dose
mirror of https://github.com/navanchauhan/Daily-Dose.git
1
0
Fork 0
Code Issues Projects Releases Wiki Activity

Added daily report

This commit is contained in:
Navan Chauhan 2023-12-17 12:42:44 +00:00
parent a5f120a612
commit 40b05d3d0b
3 changed files with 586 additions and 2 deletions
Show Stats Download Patch File Download Diff File Expand all files Collapse all files

174
archive-covid-19/17 December, 2023.html Normal file
View File

@ -0,0 +1,174 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>17 December, 2023</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
ul.task-list{list-style: none;}
</style>
<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation</strong> -
<div>
The 800 million human infections with SARS-CoV-2 and the likely emergence of new variants and additional coronaviruses necessitate a better understanding of the essential spike glycoprotein and the development of immunogens that foster broader and more durable immunity. The S2 fusion subunit is more conserved in sequence, is essential to function, and would be a desirable immunogen to boost broadly reactive antibodies. It is, however, unstable in structure and in its wild-type form, cannot be expressed alone without irreversible collapse into a six-helix bundle. In addition to the irreversible conformational changes of fusion, biophysical measurements indicate that spike also undergoes a reversible breathing action. However, spike in an open, -breathing- conformation has not yet been visualized at high resolution. Here we describe an S2-only antigen, engineered to remain in its relevant, pre-fusion viral surface conformation in the absence of S1. We also describe a panel of natural human antibodies specific for S2 from vaccinated and convalescent individuals. One of these mAbs, from a convalescent individual, afforded a high-resolution cryo-EM structure of the prefusion S2. The structure reveals a complex captured in an -open- conformation with greater stabilizing intermolecular interactions at the base and a repositioned fusion peptide. Together, this work provides an antigen for advancement of next-generation -booster- immunogens and illuminates the likely breathing adjustments of the coronavirus spike.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.14.571764v1" target="_blank">Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation</a>
</div></li>
<li><strong>SARS-CoV-2 and other coronaviruses in rats, Berlin, Germany, 2023</strong> -
<div>
We tested 130 rats trapped in Berlin for coronaviruses. Antibodies against SARS-CoV-2 were detected in a single animal only, but not in further 66 rats from the same location, speaking against virus circulation in the rat population. All animals tested negative for SARS-CoV-2 by RT-PCR. However, rodent-associated alphacoronaviruses were found.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.15.571826v1" target="_blank">SARS-CoV-2 and other coronaviruses in rats, Berlin, Germany, 2023</a>
</div></li>
<li><strong>“Life would have been harder, harder and more in chaos, if there wasn’t internet”: Digital Inclusion among Newly Arrived Refugees in Australia during the Covid-19 Pandemic</strong> -
<div>
Globally we are living through a continuing transition into the ‘information age’, where information and communication technology has transformed almost every aspect of people’s lives. The COVID-19 pandemic arguably accelerated this change. For refugees, as with other people, digital inclusion is arguably critical to social inclusion. This article seeks to better understand the digital inclusion of refugees during the COVID-19 pandemic, using data from two phases of research conducted in 2020 and 2021 with refugees who had recently resettled in Australia. Digital inclusion was mapped against three domains – access, affordability, and literacy – used in the annual Australian Digital Inclusion Index. Our research makes three contributions: it examines levels of digital inclusion among recently arrived refugees; it explores the relation of these levels to social links and bonds; and discusses differences within the sample according to gender, age, language group and type of digital inclusion.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/nqu8c/" target="_blank">“Life would have been harder, harder and more in chaos, if there wasn’t internet”: Digital Inclusion among Newly Arrived Refugees in Australia during the Covid-19 Pandemic</a>
</div></li>
<li><strong>How Generative AI Portrays Science. Interviewing ChatGPT from the Perspective of Different Audience Segments</strong> -
<div>
Generative AI in general and ChatGPT in particular have risen in importance. ChatGPT is widely known and used increasingly as an information source for different topics, including science. It is therefore relevant how ChatGPT portrays science and science-related topics. Research on this question is lacking, however. Hence, we “interview” ChatGPT and reconstruct how it presents science, scientists, scientific misbehavior and controversial scientific fields. Combining qualitative and quantitative content analysis, we find that, generally, ChatGPT portrays science largely as the STEM disciplines, in a positivist-empiricist way and a positive light. We compare ChatGPT’s responses to different simulated user profiles and two versions of GPT and find similarities in that the scientific consensus on questions like climate change, COVID-19 vaccinations or astrology is consistently conveyed across them. Beyond these similarities in substance, however, pronounced differences are found in the personalization of responses to different user profiles and between GPT-3.5 and GPT-4.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/erf36/" target="_blank">How Generative AI Portrays Science. Interviewing ChatGPT from the Perspective of Different Audience Segments</a>
</div></li>
<li><strong>A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia</strong> -
<div>
Pathogen clearance and resolution of inflammation in patients with pneumonia require an effective local T cell response. Nevertheless, local T cell activation may drive lung injury, particularly during prolonged episodes of respiratory failure characteristic of severe SARS-CoV-2 pneumonia. While T cell responses in the peripheral blood are well described, the evolution of T cell phenotypes and molecular signatures in the distal lung of patients with severe pneumonia caused by SARS-CoV-2 or other pathogens is understudied. Accordingly, we serially obtained 432 bronchoalveolar lavage fluid samples from 273 patients with severe pneumonia and respiratory failure, including 74 unvaccinated patients with COVID-19, and performed flow cytometry, transcriptional, and T cell receptor profiling on sorted CD8+ and CD4+ T cell subsets. In patients with COVID-19 but not pneumonia secondary to other pathogens, we found that early and persistent enrichment in CD8+ and CD4+ T cell subsets correlated with survival to hospital discharge. Activation of interferon signaling pathways early after intubation for COVID-19 was associated with favorable outcomes, while activation of NF-{kappa}B-driven programs late in disease was associated with poor outcomes. Patients with SARS-CoV-2 pneumonia whose alveolar T cells preferentially targeted the Spike and Nucleocapsid proteins tended to experience more favorable outcomes than patients whose T cells predominantly targeted the ORF1ab polyprotein complex. These results suggest that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterize patients who recover, yet these responses progress to NF-{kappa}B activation against non-structural proteins in patients who go on to experience poor clinical outcomes.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.13.571479v1" target="_blank">A distinctive evolution of alveolar T cell responses is associated with clinical outcomes in unvaccinated patients with SARS-CoV-2 pneumonia</a>
</div></li>
<li><strong>Scm6A: A fast and low-cost method for quantifying m6A modifications at the single-cell level</strong> -
<div>
It is widely accepted that m6A exhibits significant intercellular specificity, which poses challenges for its detection using existing m6A quantitative methods. In this study, we introduce Scm6A, a machine learning-based approach for single-cell m6A quantification. Scm6A leverages input features derived from the expression levels of m6A trans regulators and cis sequence features, and found that Scm6A offers remarkable prediction efficiency and reliability. To further validate the robustness and precision of Scm6A, we applied a winscore-based m6A calculation method to conduct m6A-seq analysis on CD4+ and CD8+ T-cells isolated through magnetic-activated cell sorting (MACS). Subsequently, we employed Scm6A for analysis on the same samples. Notably, the m6A levels calculated by Scm6A exhibited a significant positive correlation with m6A quantified through m6A-seq in different cells isolated by MACS, providing compelling evidence for Scm6A's reliability. Additionally, we performed single-cell level m6A analysis on lung cancer tissues as well as blood samples from COVID-19 patients, and demonstrated the landscape and regulatory mechanisms of m6A in different T-cell subtypes from these diseases. In summary, our work has yielded a novel, dependable, and accurate method for single-cell m6A detection. We are confident that Scm6A have broad applications in the realm of m6A-related research.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.14.571511v1" target="_blank">Scm6A: A fast and low-cost method for quantifying m6A modifications at the single-cell level</a>
</div></li>
<li><strong>Inactivation of the Niemann Pick C1 cholesterol transporter 1 (NPC1) restricts SARS-CoV-2 infection</strong> -
<div>
The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in the late endosome/lysosome (LE/Ly) and is involved in cholesterol mobilization. Loss-of-function mutations of the NPC1 gene lead to accumulation of cholesterol and sphingolipids in LE/Ly, resulting in severe fatal NPC1 disease. Cellular alterations associated with NPC1 inactivation affect both the integrity of lipid rafts and the endocytic pathway. Because the angiotensin-converting enzyme 2 (ACE2) and type 2 serine transmembrane protease (TMPRSS2) of the SARS-CoV-2 Spike (S) protein also localize to lipid rafts, we sought to investigate the hypothesis that NPC1 inactivation would generate an intrinsically unfavorable barrier to SARS-CoV-2 entry. In this study, we demonstrate that NPC1 pharmacological inactivation or CRISP/R-Cas mediated ablation of NPC1 dramatically reduced SARS-CoV-2 infectivity. More specifically, our findings demonstrate that pharmacological inactivation of NPC1 results in massive accumulation of ACE2 in the autophagosomal/lysosomal compartment. A &gt;40-fold decrease in virus titer indicates that this effectively prevents VSV-Spike-GFP infection by impeding virus binding and entry. A similarly marked decrease in viral infectivity is observed in cells that had NPC1 expression genetically abrogated. These observations were further confirmed in a de novo SARS-CoV-2 infection paradigm, where cells were infected with the naturally pathogenic SARS-CoV-2. Overall, this work offers strong evidence that NPC1 function is essential for successful SARS-CoV-2 infection, thus implicating NPC1 as a potential therapeutic target in COVID-19 management.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.13.571570v1" target="_blank">Inactivation of the Niemann Pick C1 cholesterol transporter 1 (NPC1) restricts SARS-CoV-2 infection</a>
</div></li>
<li><strong>Differential outcomes of infection by wild-type SARS-CoV-2 and the B.1.617.2 and B.1.1.529 variants of concern in K18-hACE2 transgenic mice</strong> -
<div>
Background: SARS-CoV-2 is a respiratory virus with neurological complications including loss of smell and taste, headache, and confusion that can persist for months or longer. Severe neuronal cell damage has also been reported in some cases. The objective of this study was to compare the infectivity of Wild-type virus, Delta and Omicron variants in transgenic mice that express the human angiotensin-converting enzyme 2 (hACE2) receptor under the control of the keratin 18 promoter (K18) and characterize the progression of infection and inflammatory response in the lung, brain medulla oblongata and olfactory bulbs of these animals. We hypothesized that Wild-type, Delta and Omicron differentially infect K18-hACE2 mice, thereby inducing distinct cellular responses. Methods: K18-hACE2 female mice were intranasally infected with Wild-type, Delta, or Omicron variants and euthanized either at 3 days post-infection (dpi) or at the humane endpoint. None of the animals infected with the Omicron variant reached the humane endpoint and were euthanized at day 8 dpi. Virological and immunological analyses were performed in the lungs, olfactory bulbs, medulla oblongata, and brains. Results: Mice infected with Wild-type and Delta display higher levels of viral RNA in the lungs than mice infected with Omicron at 3dpi. Viral RNA levels in the brains of mice infected with the Wild-type virus were however significantly lower than those observed in mice infected with either Delta or Omicron at 3dpi. Viral RNA was also detected in the medulla oblongata of mice infected by all these virus strains at 3dpi. At this time point, mice infected with the Delta virus display a marked upregulation of inflammatory makers both in the lungs and brains. Upregulation of inflammatory markers was also observed in the brains of mice infected with Omicron but not in mice infected with the Wild-type virus, suggesting that during the initial phase of the infection only the Delta and Omicron variants induce strong inflammatory response in the brain. At the humane endpoint/8dpi, mice infected by any of these strains display elevated levels of viral RNA and upregulation of a subset of inflammatory markers in the lungs. There was also a significant increase in viral RNA in the brains of mice infected with Wild-type and Delta, as compared to 3dpi. This was accompanied by an increase in the expression of most cytokines and chemokines. In contrast, mice infected with the Omicron variant showed low levels of viral RNA and downregulation of cytokines and chemokines expression at 8dpi, suggesting that brain inflammation by this variant is attenuated. Reduced RNA levels and downregulation of inflammatory markers was also observed in the medulla oblongata and olfactory bulbs of mice infected with Omicron, while infection by Wild-type and Delta resulted in high levels of viral RNA and increased expression of inflammatory makers in these organs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.09.08.556906v2" target="_blank">Differential outcomes of infection by wild-type SARS-CoV-2 and the B.1.617.2 and B.1.1.529 variants of concern in K18-hACE2 transgenic mice</a>
</div></li>
<li><strong>Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease</strong> -
<div>
Codon optimization describes the process used to increase protein production by use of alternative but synonymous codon changes. In SARS-CoV-2 mRNA vaccines codon optimizations can result in differential secondary conformations that inevitably affect a protein’s function with significant consequences to the cell. Importantly, when codon optimization increases the GC content of synthetic mRNAs, there can be an inevitable enrichment of G-quartets which potentially form G-quadruplex structures. The emerging G-quadruplexes are favorable binding sites of RNA binding proteins like helicases that inevitably affect epigenetic reprogramming of the cell by altering transcription, translation and replication. In this study, we performed a RNAfold analysis to investigate alterations in secondary structures of mRNAs in SARS-CoV-2 vaccines due to codon optimization. We show a significant increase in the GC content of mRNAs in vaccines as compared to native SARS-CoV-2 RNA sequences encoding the spike protein. As the GC enrichment leads to more G-quadruplex structure formations, these may contribute to potential pathological processes initiated by SARS-CoV-2 molecular vaccination.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/bcsa6/" target="_blank">Differences in Vaccine and SARS-CoV-2 Replication Derived mRNA: Implications for Cell Biology and Future Disease</a>
</div></li>
<li><strong>Examining perceptions of stress, wellbeing and fear among Hungarian adolescents and their parents under lockdown during the COVID-19 pandemic</strong> -
<div>
Intensified anxiety responses and even symptoms of post-traumatic stress are commonly observed under quarantine conditions. In this study, the effects on fear, anxiety and wellbeing of the recent pandemic caused by SARS-CoV-2 were investigated in a sample of otherwise healthy Hungarians. Taking the family as a microsystem, differences in gender, age, family relationships and time spent in isolation were the main focus of this investigation. 346 parent-child dyads were examined; the children were 11-17 years of age. Standard psychological questionnaires (Perceived Stress Scale, WHO Wellbeing Index), and an open question test (the Metamorphosis test) were used, and the results analysed with the aid of basic statistical methods. Stress levels and wellbeing displayed a significant negative correlation with each other in both parents and children. Parental stress and levels of wellbeing had a weak but significant impact on the wellbeing of their children. Among the demographic variables examined, none of them was found to explain the wellbeing or stress level of parents. Natural catastrophes, such as pandemics, create a stressful social environment for parents, and therefore directly impact the psychological wellbeing of all family members.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/psyarxiv/feth3/" target="_blank">Examining perceptions of stress, wellbeing and fear among Hungarian adolescents and their parents under lockdown during the COVID-19 pandemic</a>
</div></li>
<li><strong>Acceptability and feasibility of a theatre-based wellness programme to support people living with Long COVID: a single arm feasibility study.</strong> -
<div>
Objectives: To determine acceptability and feasibility of a theatre-based wellness programme to support the health and wellbeing of people with long COVID. Design: Single group, repeated measures feasibility study. Setting: Community centre and online. Participants: Adults with a diagnosis of long COVID experiencing breathlessness, mild to moderate pain, and/or loneliness. Intervention: A six-week participatory creative intervention delivered to two groups of participants, one online and one in-person. The groups were facilitated by movement, voice and drama consultants and designed to improve wellbeing, fatigue, pain, strength and balance through a series of breathing exercises, visualisation, group singing and sound imagery, storytelling, movement exercises and poetry. Primary outcome measures: Acceptability of the intervention and feasibility of recruitment procedures and data collection. Secondary outcome measures: Changes in mental health, wellbeing, quality of life, loneliness, social support, fatigue, breathlessness, and post-COVID-19 functional status. Results: 20 participants took part in the intervention, 19 completed baseline assessments and 16 completed study follow-up. Most participants found the programme acceptable and feasible and improvements were identified in all outcomes at 8-week follow-up, including decreases in generalised anxiety and depressive symptoms, loneliness, shortness of breath, respiratory dysfunction, chronic fatigue and increased mental wellbeing, social support, and self-rated health. Key programme features and mechanisms of action that led to improvements in health and wellbeing were identified in qualitative interviews. Barriers to engagement included: activities being outside of the participant’s comfort zone, ongoing and fluctuating long COVID symptoms, emotional consequences of sharing experiences with the group and connectivity and connecting with others online. Conclusions: A six-week theatre-based programme was perceived as acceptable to most participants and resulted in positive psychosocial impacts. The findings provide a rationale for supporting the ongoing development of this and related programmes and for scaling up research into arts programmes to support people living with long COVID.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/k25qj/" target="_blank">Acceptability and feasibility of a theatre-based wellness programme to support people living with Long COVID: a single arm feasibility study.</a>
</div></li>
<li><strong>Artificial Intelligence and Robotics for Reducing Waste in the Food Supply Chain: Systematic Literature Review, Theoretical Framework, and Research Agenda</strong> -
<div>
The COVID-19 pandemic has unraveled the inefficiencies in the global food supply chain. One glaring distortion is the wastage of close to a third of global food production, in the face of widespread food insecurity. With population explosion and climate change as additional pressure points, reducing food waste has emerged as an urgent imperative for achieving food security for all. In this paper, we develop a research framework and agenda for the use of Artificial Intelligence and robotics in reducing food loss and waste. The Cognitive Automation for Food (COGAF) has been developed as a theoretical framework for guiding future research. This framework delineates the research landscape into five distinct research streams: sensory enhancement, cognitive automation, physical automation, sensory-motor fusion, and collaborative automation. In order to develop a systematic research agenda, propositions have been developed in each of these research streams. In conjunction with the COGAF framework, this research agenda attempts to provide a road map for future research and knowledge creation pertaining to the use of AI and robotics to reduce food loss and waste.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/h3jgb/" target="_blank">Artificial Intelligence and Robotics for Reducing Waste in the Food Supply Chain: Systematic Literature Review, Theoretical Framework, and Research Agenda</a>
</div></li>
<li><strong>Ursodeoxycholic acid and severe COVID-19 outcomes in people with liver disease: a cohort study using the OpenSAFELY platform</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Biological evidence suggests ursodeoxycholic acid (UDCA) - a common treatment of cholestatic liver disease - may prevent severe COVID-19 outcomes. With the approval of NHS England, we conducted a population-based cohort study using primary care records, linked to death registration data and hospital records through the OpenSAFELY-TPP platform. We estimated the hazard of COVID-19 hospitalisation or death between 1 March 2020 and 31 December 2022, comparing UDCA treatment to no UDCA treatment in a population with indication. Of 11,320 eligible individuals, 642 were hospitalised or died with COVID-19 during follow-up, 402 (63%) events among UDCA users. After confounder adjustment, UDCA was associated with a 21% (95% CI 7%-33%) relative reduction in the hazard of COVID-19 hospitalisation or death, consistent with an absolute risk reduction of 1.3% (95% CI 1.0%-1.6%). Our findings support calls for clinical trials investigating UDCA as a preventative measure for severe COVID-19 outcomes.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2023.12.11.23299191v1" target="_blank">Ursodeoxycholic acid and severe COVID-19 outcomes in people with liver disease: a cohort study using the OpenSAFELY platform</a>
</div></li>
<li><strong>A software tool for at-home measurement of sensorimotor adaptation</strong> -
<div>
Sensorimotor adaptation is traditionally studied in well-controlled laboratory settings with specialized equipment. However, recent public health concerns such as the COVID-19 pandemic, as well as a desire to recruit a more diverse study population, have led the motor control community to consider at-home study designs. At-home motor control experiments are still rare because of the requirement to write software that can be easily used by anyone on any platform. To this end, we developed software that runs locally on a personal computer. The software provides audiovisual instructions and measures the ability of the subject to control the cursor in the context of visuomotor perturbations. We tested the software on a group of at-home participants and asked whether the adaptation principles inferred from in-lab measurements were reproducible in the at-home setting. For example, we manipulated the perturbations to test whether there were changes in adaptation rates (savings and interference), whether adaptation was associated with multiple timescales of memory (spontaneous recovery), and whether we could selectively suppress subconscious learning (delayed feedback, perturbation variability) or explicit strategies (limited reaction time). We found remarkable similarity between in-lab and at-home behaviors across these experimental conditions. Thus, we developed a software tool that can be used by research teams with little or no programming experience to study mechanisms of adaptation in an at-home setting.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.12.571359v1" target="_blank">A software tool for at-home measurement of sensorimotor adaptation</a>
</div></li>
<li><strong>Identification of an allele-specific transcription factor binding interaction that regulates PLA2G2A gene expression</strong> -
<div>
The secreted phospholipase A2 (sPLA2) isoform, sPLA2-IIA, has been implicated in a variety of diseases and conditions, including bacteremia, cardiovascular disease, COVID-19, sepsis, adult respiratory distress syndrome, and certain cancers. Given its significant role in these conditions, understanding the regulatory mechanisms impacting its levels is crucial. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs), including rs11573156, that are associated with circulating levels of sPLA2-IIA. Through Genotype-Tissue Expression (GTEx), 234 expression quantitative trait loci (eQTLs) were identified for the gene that encodes for sPLA2-IIA, PLA2G2A. SNP2TFBS (https://ccg.epfl.ch/snp2tfbs/) was utilized to ascertain the binding affinities between transcription factors (TFs) to both the reference and alternative alleles of identified SNPs. Subsequently, ChIP-seq peaks highlighted the TF combinations that specifically bind to the SNP, rs11573156. SP1 emerged as a significant TF/SNP pair in liver cells, with rs11573156/SP1 interaction being most prominent in liver, prostate, ovary, and adipose tissues. Further analysis revealed that the upregulation of PLA2G2A transcript levels through the rs11573156 variant was affected by tissue SP1 protein levels. By leveraging an ordinary differential equation, structured upon Michaelis-Menten enzyme kinetics assumptions, we modeled the PLA2G2A transcription's dependence on SP1 protein levels, incorporating the SNP's influence. Collectively, these data strongly suggest that the binding affinity differences of SP1 for the different rs11573156 alleles can influence PLA2G2A expression. This, in turn, can modulate sPLA2-IIA levels, impacting a wide range of human diseases.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2023.12.12.571290v1" target="_blank">Identification of an allele-specific transcription factor binding interaction that regulates PLA2G2A gene expression</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID</strong> - <b>Conditions</b>: Long Covid19; Exercise Intolerance, Riboflavin-Responsive <br/><b>Interventions</b>: Behavioral: Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Behavioral: Light Stretching/Breathing Exercises <br/><b>Sponsors</b>: Columbia University; New York University <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Pilot Study of Liraglutide (A Weight Loss Drug) in High Risk Obese Participants With Cognitive and Memory Issues</strong> - <b>Conditions</b>: Multiple Sclerosis; Long COVID; Long Covid19; Obese; Obesity; Obesity, Morbid; Acute Leukemia in Remission <br/><b>Interventions</b>: Drug: Liraglutide Pen Injector [Saxenda]; Other: Medication Diary <br/><b>Sponsors</b>: University of Chicago <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>EXERCISE TRAINING USING AN APP ON PHYSICAL CARDIOVASCULAR FUNCTION INDIVIDUALS WITH POST-COVID-19 SYNDROME</strong> - <b>Conditions</b>: Post-Acute COVID-19 Syndrome <br/><b>Interventions</b>: Behavioral: Exercise; Behavioral: Control <br/><b>Sponsors</b>: University of Nove de Julho <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 1 Trial of Recombinant COVID-19 Trivalent Protein Vaccine （CHO Cell）LYB002V14 in Booster Vaccination</strong> - <b>Conditions</b>: SARS-CoV-2; COVID-19 Vaccine <br/><b>Interventions</b>: Biological: 30μg dose of LYB002V14; Biological: 60μg dose of LYB002V14; Biological: placebo <br/><b>Sponsors</b>: Guangzhou Patronus Biotech Co., Ltd.; Yantai Patronus Biotech Co., Ltd. <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Vaccine Effectiveness Against Recurrent Infection Among Lung Cancer Patients and Biomarker Research</strong> - <b>Conditions</b>: COVID-19 Recurrent; Lung Cancer; Vaccination; Antibody; Chemotherapy; Immune Checkpoint Inhibitor <br/><b>Interventions</b>: Biological: Any Chinese government-recommended COVID-19 booster vaccine <br/><b>Sponsors</b>: Peking Union Medical College Hospital <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMMUNERECOV CONTRIBUTES TO IMPROVEMENT OF RESPIRATORY AND IMMUNOLOGICAL RESPONSE IN POST-COVID-19 PATIENTS.</strong> - <b>Conditions</b>: Long Covid19; Dietary Supplements; Respiratory Tract Infections; Inflammation <br/><b>Interventions</b>: Dietary Supplement: Nutritional blend (ImmuneRecov). <br/><b>Sponsors</b>: Federal University of São Paulo <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Physical Activity Coaching in Patients With Post-COVID-19</strong> - <b>Conditions</b>: Post-COVID-19 Syndrome <br/><b>Interventions</b>: Behavioral: Self-monitoring; Behavioral: Goal setting and review; Behavioral: Education; Behavioral: Feedback; Behavioral: Contact; Behavioral: Exercise; Behavioral: Report; Behavioral: Social support; Behavioral: Group activities; Behavioral: World Health Organization recommendations for being physically active <br/><b>Sponsors</b>: University of Alcala; Professional College of Physiotherapists of the Community of Madrid <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients by Respiratory Training</strong> - <b>Conditions</b>: COVID-19, Post-Acute COVID-19 Syndrome, Dyspnea, Incentive Spirometer <br/><b>Interventions</b>: Device: breathing training <br/><b>Sponsors</b>: Tri-Service General Hospital <br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID</strong> - <b>Conditions</b>: Long COVID; Post Acute Sequelae of COVID-19; Post-Acute COVID-19 <br/><b>Interventions</b>: Drug: Ensitrelvir; Other: Placebo <br/><b>Sponsors</b>: Timothy Henrich; Shionogi Inc. <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Low-intensity Aerobic Training Associated With Global Muscle Strengthening in Post-COVID-19</strong> - <b>Conditions</b>: COVID-19 <br/><b>Interventions</b>: Procedure: muscle strengthening <br/><b>Sponsors</b>: Centro Universitário Augusto Motta <br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intravenous Immunoglobulin Replacement Therapy for Persistent COVID-19 in Patients With B-cell Impairment</strong> - <b>Conditions</b>: COVID-19 <br/><b>Interventions</b>: Drug: Immunoglobulins <br/><b>Sponsors</b>: Jaehoon Ko <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Inhaled Hydroxy Gas on Long COVID Symptoms</strong> - <b>Conditions</b>: Post-Acute COVID-19 Syndrome <br/><b>Interventions</b>: Device: Hydroxy gas <br/><b>Sponsors</b>: Oxford Brookes University <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Community Care Intervention to Decrease COVID-19 Vaccination Inequities</strong> - <b>Conditions</b>: COVID-19 Vaccination <br/><b>Interventions</b>: Behavioral: Community Health Worker Intervention to Enhance Vaccination Behavior (CHW-VB) <br/><b>Sponsors</b>: RAND; Clinical Directors Network; National Institute on Minority Health and Health Disparities (NIMHD) <br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PROmotion of COVID-19 BOOSTer VA(X)Ccination in the Emergency Department - PROBOOSTVAXED</strong> - <b>Conditions</b>: COVID-19 <br/><b>Interventions</b>: Behavioral: Vaccine Messaging; Behavioral: Vaccine Acceptance Question <br/><b>Sponsors</b>: University of California, San Francisco; National Institute of Allergy and Infectious Diseases (NIAID); Pfizer; Duke University; Baylor College of Medicine; Thomas Jefferson University <br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial</strong> - <b>Conditions</b>: Long-COVID; Long Covid19; Post-COVID-19 Syndrome; Post-COVID Syndrome; Fatigue <br/><b>Interventions</b>: Other: COVIDEx <br/><b>Sponsors</b>: Lawson Health Research Institute; Western University <br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2</strong> - During the coronavirus reproduction process, 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro) are accountable for the fragmentation of two polyprotein precursors (pp1a/pp1ab) into substructural proteins. These two proteins are vital for the replication and transcription of the viral genome. Therefore, 3CLpro is a key protein and target for the design of coronavirus inhibitors. In previous studies, we found that betulinic acid has an inhibitory effect on 3CLpro, with 51.5 %…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chlorogenic acid inhibits porcine deltacoronavirus release by targeting apoptosis</strong> - Porcine deltacoronavirus (PDCoV), belonging to family Coronaviridae, genus Deltacoronavirus, can cause acute diarrhea in piglets, and also possesses cross-species transmission potential, leading to severe economic losses and threatening public health. However, no approved drug against PDCoV infection is available. Here, we investigated the antiviral effect of chlorogenic acid (CGA), the main active component of Lonicerae Japonicae Flos, against PDCoV infection. The results showed that CGA…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protective Efficacy of Novel Engineered Human ACE2-Fc Fusion Protein Against Pan-SARS-CoV-2 Infection In Vitro and in Vivo</strong> - Enduring occurrence of severe COVID-19 for unvaccinated, aged, or immunocompromised individuals remains an urgent need. Soluble human angiotensin-converting enzyme 2 (ACE2) has been used as a decoy receptor to inhibit SARS-CoV-2 infection, which is limited by moderate affinity. We describe an engineered, high-affinity ACE2 that is consistently effective in tissue cultures in neutralizing all strains tested, including Delta and Omicron. We also found that treatment of AC70 hACE2 transgenic mice…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>C<sub>60</sub> -based Multivalent Glycoporphyrins Inhibit SARS-CoV-2 Specific Interaction with the DC-SIGN Transmembrane Receptor</strong> - Since WHO has declared the COVID-19 outbreak a global pandemic, nearly seven million deaths have been reported. This efficient spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is facilitated by the ability of the spike glycoprotein to bind multiple cell membrane receptors. Although ACE2 is identified as the main receptor for SARS-CoV-2, other receptors could play a role in viral entry. Among others, C-type lectins such as DC-SIGN are identified as efficient trans-receptor…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DYRK1A is a multifunctional host factor that regulates coronavirus replication in a kinase-independent manner</strong> - Coronaviruses, like other positive-sense RNA viruses, can remodel the host membrane to form double-membrane vesicles (DMVs) as their replication organelles. Currently, host factors involved in DMV formation are not well defined. In this study, we used transmissible gastroenteritis virus (TGEV) as a virus model to investigate the regulatory mechanism of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) on coronavirus. Results showed that DYRK1A significantly inhibited TGEV…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase I study, and dosing regimen selection for a pivotal COVID-19 trial of GST-HG171</strong> - This study is aimed to evaluate the safety, tolerability, and pharmacokinetics (PK), as well as to select an appropriate dosing regimen for the pivotal clinical trial of GST-HG171, an orally bioavailable, potent, and selective 3CL protease inhibitor by a randomized, double-blind, and placebo-controlled phase I trial in healthy subjects. We conducted a Ph1 study involving 78 healthy subjects to assess the safety, tolerability, and PK of single ascending doses (150-900 mg) as well as multiple…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Promises and Pitfalls of Calcineurin Inhibitors in COVID-19: A Systematic Review and Meta-analysis of Controlled Trials</strong> - CONCLUSION: CIs are able to inhibit the virus nucleocapsid protein so that they can prevent replication and respiratory tract tissue damage caused by SARS-CoV-2. Based on the characteristics mentioned in detail, CIs can play a potential therapeutic role for COVID-19 patients.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor</strong> - Viruses communicate with their hosts through interactions with proteins, lipids, and carbohydrate moieties on the plasma membrane (PM), often resulting in viral absorption via receptor-mediated endocytosis. Many viruses cannot multiply unless the host’s cholesterol level remains steady. The large endo/lysosomal membrane protein (MP) Niemann-Pick C1 (NPC1), which is involved in cellular cholesterol transport, is a crucial intracellular receptor for viral infection. NPC1 is a ubiquitous…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice</strong> - CONCLUSIONS: This study confirmed the attenuating effect of acarbose on P. aeruginosa RTIs in T2DM and nondiabetic mice and investigated its mechanism, providing novel support for its clinical application in related diseases.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex</strong> - Nucleotide analogues (NA) are currently employed for treatment of several viral diseases, including COVID-19. NA prodrugs are intracellularly activated to the 5’-triphosphate form. They are incorporated into the viral RNA by the viral polymerase (SARS-CoV-2 nsp12), terminating or corrupting RNA synthesis. For Coronaviruses, natural resistance to NAs is provided by a viral 3’-to-5’ exonuclease heterodimer nsp14/nsp10, which can remove terminal analogues. Here, we show that the replacement of the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical phenotype and outcome of persistent SARS-CoV-2 replication in immunocompromised hosts: a retrospective observational study in the Omicron era</strong> - CONCLUSION: Ongoing SARS-CoV-2 replication in the lower respiratory tract is a relevant differential diagnosis in patients with severe immunosuppression and continuous cough, fever or dyspnoea even if nasopharyngeal swabs test negative for SARS-CoV-2. Especially in B cell-depleted patients, this may lead to inflammatory or fibrotic-like pulmonary changes, which are partially reversible after inhibition of viral replication. Antiviral therapy seems to be most effective in combination and over a…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibitory effect of napabucasin on arbidol metabolism and its mechanism research</strong> - As a broad-spectrum antiviral, and especially as a popular drug for treating coronavirus disease 2019 (COVID-19) today, arbidol often involves drug-drug interactions (DDI) when treating critical patients. This study established a rapid and effective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to detect arbidol and its metabolite arbidol sulfoxide (M6-1) levels in vivo and in vitro. In this study, a 200 μL incubation system was used to study the inhibitory…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tumor Treating Fields (TTFields) demonstrate antiviral functions <em>in vitro</em>, and safety for application to COVID-19 patients in a pilot clinical study</strong> - Coronaviruses are the causative agents of several recent outbreaks, including the COVID-19 pandemic. One therapeutic approach is blocking viral binding to the host receptor. As binding largely depends on electrostatic interactions, we hypothesized possible inhibition of viral infection through application of electric fields, and tested the effectiveness of Tumor Treating Fields (TTFields), a clinically approved cancer treatment based on delivery of electric fields. In preclinical models,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Repurposing of Rutan showed effective treatment for COVID-19 disease</strong> - Previously, from the tannic sumac plant (Rhus coriaria), we developed the Rutan 25 mg oral drug tablets with antiviral activity against influenza A and B viruses, adenoviruses, paramyxoviruses, herpes virus, and cytomegalovirus. Here, our re-purposing study demonstrated that Rutan at 25, 50, and 100 mg/kg provided a very effective and safe treatment for COVID-19 infection, simultaneously inhibiting two vital enzyme systems of the SARS-CoV-2 virus: 3C-like proteinase (3CLpro) and RNA-dependent…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of the K<sub>Ca</sub>2 potassium channel in atrial fibrillation: a randomized phase 2 trial</strong> - Existing antiarrhythmic drugs to treat atrial fibrillation (AF) have incomplete efficacy, contraindications and adverse effects, including proarrhythmia. AP30663, an inhibitor of the K(Ca)2 channel, has demonstrated AF efficacy in animals; however, its efficacy in humans with AF is unknown. Here we conducted a phase 2 trial in which patients with a current episode of AF lasting for 7 days or less were randomized to receive an intravenous infusion of 3 or 5 mg kg^(-1) AP30663 or placebo. The…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<script>AOS.init();</script></body></html>

410
archive-daily-dose/17 December, 2023.html Normal file
View File

@ -0,0 +1,410 @@
<!DOCTYPE html>
<html lang="" xml:lang="" xmlns="http://www.w3.org/1999/xhtml"><head>
<meta charset="utf-8"/>
<meta content="pandoc" name="generator"/>
<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
<title>17 December, 2023</title>
<style>
code{white-space: pre-wrap;}
span.smallcaps{font-variant: small-caps;}
span.underline{text-decoration: underline;}
div.column{display: inline-block; vertical-align: top; width: 50%;}
div.hanging-indent{margin-left: 1.5em; text-indent: -1.5em;}
ul.task-list{list-style: none;}
</style>
<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
<body>
<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How a Student Group Is Politicizing a Generation on Palestine</strong> - Activists with Students for Justice in Palestine have mobilized major campus demonstrations in support of Gaza—and provided an intellectual framework for protesters watching what’s happening in the Middle East. - <a href="https://www.newyorker.com/news/annals-of-education/how-a-generation-is-being-politicized-on-palestine">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The U.N. Human-Rights Chief and the Fugitive Princess of Dubai</strong> - Michelle Bachelet’s private meeting with Sheikha Latifa bint Mohammed Al Maktoum was viewed as proof that a long-imprisoned royal was finally free. In her first interview about the encounter, Bachelet reveals her doubts. - <a href="https://www.newyorker.com/news/news-desk/the-un-human-rights-chief-and-the-fugitive-princess-of-dubai">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Congressional Christmas Gift to Putin</strong> - Biden’s signature support for Ukraine goes from “as long as it takes” to “as long as we can.” - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/a-congressional-christmas-gift-to-putin">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Chancellor of Berkeley Weighs In</strong> - Carol Christ reflects on campus protests, then and now. - <a href="https://www.newyorker.com/news/the-new-yorker-interview/the-chancellor-of-berkeley-weighs-in">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Watching Rudy Giuliani Self-Destruct at a Defamation Trial in Washington</strong> - A jury decided that Giuliani owes two election workers whom he defamed nearly a hundred and fifty million dollars. Even his lawyer suggested he “hasn’t been so great lately.” - <a href="https://www.newyorker.com/news/the-political-scene/watching-rudy-giuliani-self-destruct-at-a-defamation-trial-in-washington">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>How to navigate a chronic illness</strong> -
<figure>
<img alt="Illustration of a solitary bus passenger siting and wearing a mask." src="https://cdn.vox-cdn.com/thumbor/xpu1HV7pOr-Snh21v8G7FbsP-mI=/286x0:2021x1301/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72971590/GettyImages_1215979660__1_.0.jpg"/>
<figcaption>
Getty Images/fStop
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Whether it’s your own or someone else’s.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ULvOmO">
In 2020, Dave Venus couldn’t catch a break. First, he got sick with a mysterious illness that caused him constant fatigue. Then, a week before his wife, Claire, gave birth to their daughter, both of them got <a href="https://www.vox.com/coronavirus-covid19">Covid-19</a>. Dave couldn’t be in the delivery room. After the birth, while Claire made every effort to recover and care for the newborn, Dave was diagnosed as having H.pylori, a bacteria that can infect the stomach and small intestine, likely the trigger of his initial sudden illness. Claire’s Covid cleared up, but Dave’s never did. He developed an array of long Covid symptoms: tingling hands and feet, crushing pressure on his chest, heart racing like he’d run a marathon. The ongoing symptoms made it impossible for him to do even small tasks around the house, let alone return to his job as a physical trainer. But his bloodwork looked fine, and doctors said there was nothing else to do.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DX5mJI">
“I became obsessed with finding solutions,” Claire said, “I took to <a href="https://www.vox.com/twitter">Twitter</a>, where people were talking about going to Germany and having their blood cleaned, and there were osteopaths and floatation tanks and all the other kinds of stress relief stuff.” She knew these treatments weren’t likely to be effective, but, she said, “I was just desperate to try and help him heal.” Dave, on the other hand, tended to look for solace in prayer and meditation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jDEvjI">
“I just felt the sickness was stalking me and I was exhausted trying to keep two steps ahead of it,” Dave said. The ensuing journey for Dave, with his chronic illness, and Claire, as his primary supporter, would be long, winding, and unpredictable.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GhpWuR">
Dave’s experience isn’t unique. And it reflects a problem bigger than even long Covid. The incidence of chronic illness is growing rapidly, and today <a href="https://www.cdc.gov/chronicdisease/resources/infographic/chronic-diseases.htm">six in 10 Americans have at least one chronic disease</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="knQ1a5">
These include widespread diseases like Type 2 diabetes and hypertension, as well as rapidly rising autoimmune diseases like lupus, inflammatory bowel disease, Type 1 diabetes, and dozens of other disorders that <a href="https://autoimmune.org/wp-content/uploads/2019/12/1-in-5-Brochure.pdf">now affect one in five Americans</a>. Some autoimmune conditions can hit in the prime of life, meaning that more people are grappling with the implications of living with chronic illness for decades. Long Covid, which has an autoimmune component, accelerated and highlighted this trend. Even <a href="https://www.vox.com/2016/3/2/11141452/living-with-cancer-chronic">many types of cancer, with new management techniques, have become chronic illnesses</a>. Most people today either struggle with a chronic illness or know someone who does.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vrOGcu">
These conditions challenge many of the cultural narratives about illness that underlie our medical system: that sickness should be fixed, that we address disease with medical interventions and get better on a certain timeline, that we overcome. Instead, people with chronic illness face immense uncertainty about the duration and trajectory of their diseases, often live without clear medical explanations and guidelines, and typically experience cycles of worse and better health rather than a neat linear path back to <a href="https://www.vox.com/health">wellness</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V6NGt7">
As a result, whether you have a chronic illness or know someone who does, it can be difficult to figure out how to process the new reality and find ways to create a fulfilling life in the context of uncertainty and new constraints. Here are some ideas from patients, supporters, and <a href="https://www.vox.com/health-care">health care</a> practitioners.
</p>
<h3 id="MLHI3h">
It’s important to acknowledge grief
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BE18Bn">
We tend to associate grief with death and bereavement, but chronic conditions also come with loss and grieving. “You might lose all sorts of things through illness,” said Emily Bazalgette, who suddenly came down with unexplained, debilitating fatigue at the age of 28 and was eventually diagnosed with a host of chronic diseases including long Covid. “You might lose your identity, your career, relationships, hobbies, your lifestyle. Your sense of safety, your sense of trust in your body, and also the futures that you had imagined for yourself. That’s a lot.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hc4jXS">
All of these losses require a grieving process, says Bazalgette, who now conducts interviews, facilitates group discussion, and writes a newsletter on chronic illness grief, all while managing her ongoing fatigue. But for many people with chronic conditions and their supporters, it’s not obvious that grief is at the center of the experience, and there are few resources for those going through it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6Xgi4n">
“I wish I had known that word earlier,” said Bazalgette. “For a long time I was very angry. I was jealous of other people who were not ill. I spent a lot of time writing very angrily in my journal. It’s hard to feel our grief, so it can manifest as other things, like rage. But over time, I was able to get to the sadness and the sorrow underneath.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="btHKNj">
Deborah Miller, who has spent decades as a therapist at the Cleveland Clinic working with patients and families with multiple sclerosis, noted the same theme. “Whether [patients] put the word to it or not, we identify it as a grieving process. That really resonates with people. They are grieving the loss of themselves and who they were.” It can be a relief to have a name for the experience and to know that it is both common and normal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pBFoRx">
Inevitably, this grieving process will be different for every person, making it difficult to know how to navigate the process or support someone who is going through it. Meghan Jobson, internist and co-author of the book <em>Long Illness: A Practical Guide to Surviving, Healing, and Thriving</em>, says it will involve learning about yourself or your loved one in this new phase of life.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nk9yFM">
“Having a new chronic illness identity is no different than when people have experiences with another new identity,” said Jobson. “Like when people come out, when people become parents, when people go to college — during all these big changes where we’re learning new things about ourselves and we’re evolving.”
</p>
<h3 id="yTIvVH">
Allow time to adjust to the new normal
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="alKnGi">
Adjusting to a new chronic illness rarely happens quickly, which challenges the common desire to find the solution and move on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zfklgb">
While some chronic conditions come with clear medical guidelines, many do not, and people facing ongoing symptoms can easily become overwhelmed with trying to learn all the information available to fix the problem. This is often an impossible task and can cause feelings of paralysis and anxiety. “There’s usually a deep desire to learn everything to do because so much focus is on doing things the right way,” said Beth Kane, a clinical social worker and integrative therapist who focuses on clients with chronic illness.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1IYab5">
On top of that, well-intentioned efforts from loved ones to propose possible solutions can add to the overwhelm. Juliet Morgan, a physician, co-author of <em>Long Illness,</em> and a neurologist and psychiatrist who works with people with chronic conditions, recognized this pattern in herself in her early career. “I went to medical school steeped in this thought that I was going to make people better. And that was my job, and that if I didn’t, I was doing something wrong.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="I9D12b">
This is a common sentiment among supporters as well as doctors, Morgan said. But it can be more damaging than helpful in the case of chronic conditions, when “getting better,” in the sense of returning to life the way it was before, may not be possible. Messages on social media about bravery, tips and tricks for wellness, and stories about people pushing through and winning can be further damaging because they imply that the sick person should be able to solve their health problems. Posts like “Wake up every morning and fight” or “Your strength and courage defines you” can sound uplifting, but actually add to the emotional burden of illness.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="H2ICxQ">
“We put pressure on people that they need to perform perfection, even while they’re totally struggling,” said Morgan.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EtgDyW">
The healthy alternative, according to Kane, Jobson, and Morgan, is to allow time for the process to unfold, including the loss and grief, a shifting identity, major lifestyle changes, and figuring out what works within the new reality. Accepting the drawn-out nature of this process can be challenging for both those with chronic illnesses and their supporters.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Gour8z">
“It’s really, really hard,” Morgan acknowledged. “It’s really hard because it forces you to realize you don’t have control, that none of us really do.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dD7iCC">
While allowing time for this adjustment is important, there may be indications that you or a loved one should seek professional help. In particular, it’s important to watch for signs of depression, including losing interest in hobbies, friends, or things that once were pleasurable; changes in sleep or appetite; changes in concentration; or persistent feelings of hopelessness. If someone is considering ending their life, seek professional help immediately.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oObKDl">
Depression and other <a href="https://www.vox.com/mental-health">mental health</a> issues can show up in other ways, too; when in doubt, it’s important to talk to a licensed mental health professional.
</p>
<h3 id="u4FfCq">
Cultivating creativity and community can be therapeutic
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TcsJQn">
Even as loss is a defining feature of chronic illness, the changes and new constraints can also prompt discoveries and creative approaches to living. The key for many people with chronic illness is identifying what really matters to them and figuring out new ways to achieve that within the constraints, says therapist Deborah Miller. “I had one patient [with MS] who, the day I met her, she was in four-inch spiky heels, and she swore that she was never ever going to give up her four-inch spikes. I thought that we were headed for trouble,” said Miller.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jURLCU">
But as the disease progressed, Miller’s patient adapted. She could no longer walk in heels, so “sometimes she would go to parties … in her flats and then put her high heels on when she sat down so that she had a sense of being that fashionable person, but in a safe way. It’s about keeping in mind what’s important to you.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="14BkFO">
For Kathryn Vercillo, who has struggled for decades with major depressive disorder as well as a host of physical symptoms like fatigue and brain fog, learning to crochet has been foundational to her health and sense of purpose. “I couldn’t get away from the feeling that if I was doing nothing, I was worthless. So I had to find something that I could do lying down and that was portable and cheap. With crochet, I could make a gift for someone or I could make a blanket for myself. Turning a piece of yarn into something is a magical thing.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AtTRhf">
Vercillo has since interviewed hundreds of chronically ill women about using crochet and knitting as part of their healing process, and has found that, for many people, these creative acts offer a sense of purpose. “We all need purpose. Making things and gifting things to people gives us that. Even when I am at my lowest, I can find this way to contribute, and that helped pull me out, helped rebuild some self-esteem, helped distract me.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="axrmWD">
For people with chronic illnesses, finding new ideas like this often comes from connecting with others who are having similar illness experiences. Vercillo has found this through a vibrant crochet community.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AGSfMJ">
Some people find in-person groups through a health care provider, or they find like-minded people on internet forums for a specific disease. It can be tricky to find a good fit, particularly in online forums where there is often a fire hose of recommendations and it can be unclear who is citing credible, evidence-based information. Ideally, people with chronic illnesses can explore a variety of groups and formats — <a href="https://www.vox.com/facebook">Facebook</a> forums, Zoom support groups, in-person workshops, and others — to figure out what works best for them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sYQ1PQ">
More than anything, people with chronic conditions say that these communities provide comfort and relieve isolation. “For years, I didn’t know anyone else with a similar illness, so it was a very lonely journey,” said Bazalgette. “Finding my community of people online gave me a sense of solidarity, and it also introduced me to a network of researchers, clinicians, and patient advocates who are pushing research and treatment forward, which gave me hope.”
</p>
<h3 id="xZsl5C">
Expect to receive and give help imperfectly
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OIWfq1">
For many people with chronic illnesses, particularly those who are newly diagnosed, it isn’t obvious what help they need. And within a state of overwhelm, it’s difficult to come up with ideas. Typically, friends and family who want to help also don’t know exactly what to do.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3byvnU">
“It seemed like everyone just kept saying, ‘How can I help?’ And I kept saying, ‘I don’t know.’ And then we got no help,” said Claire Venus, Dave’s wife. The best times, she said, were when someone just did something, like bringing over a meal, or offered a specific favor, like picking up their son from school.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5qvcIB">
Across the board, patients and health care professionals recommend that, when in doubt, supporters default to just listening. “You could say, ‘Do you want to talk and I’ll just listen?’” said Claire. “People are quite quick to try and move you on to a more positive frame of mind or another place, but there’s nowhere to move on to, this is so heavy. I just need to talk it out.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="p40e5c">
Morgan echoed this sentiment. “[Supporters] want to give a life raft, but sometimes you’ve just got to hold someone’s hand while they’re going through the bad part.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cK1mhb">
This approach can also help avoid common pitfalls, like offering solutions or trying to look on the bright side, which can increase feelings of overwhelm. “I really noticed a tendency of people to brush off the grief and say, ‘It isn’t so bad, Emily, other people have it worse,’” said Bazalgette. “I wish that people around me had been able to just listen to my grief and to witness it.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IRYR61">
Inevitably, in trying to adjust to the new reality, supporters and people with chronic illness will make mistakes communicating. It is helpful to expect these imperfections and frame the experience as a time of learning and growth.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PoGR5U">
“I think it’s a time as a friend and as an ally to grow as a person, and to learn, and to listen,” said Jobson. And the same thing goes for people who have chronic illnesses. “The biggest gift you can give yourself is to be patient with yourself, to be compassionate toward yourself, and to be open to different paths on the journey that can get you to the healing you want.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ekDBx5">
For the Venuses, this journey has included losses and gains. The couple now says no to many activities that used to fill their life — social engagements, work obligations, certain travel — and says yes to other ideas that may have felt too weird or scary before, like buying a used camper van and loading in their family for local summer camping trips.
</p>
<p class="c-end-para" data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XnmVEl">
It is still hard, of course. Things will not go back to how they were before, and the couple has had to remove themselves from their former lives in many ways. But on many days, they feel empowered in their decisions, like they are charting a new course. “There’s almost less fear now,” Claire said. “All the rules are made up, so we get to choose. Even if we’re living a life that nobody else understands, and even if society at large doesn’t make space for it, it’s still our life, isn’t it? It’s not anybody else’s life, it’s ours.”
</p></li>
<li><strong>A historian’s advice to the Democrats trying to build stuff</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/oSeSEKeSINW_ZhQLSJeDSWIla80=/310x0:5259x3712/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72971538/GettyImages_1236626897.0.jpeg"/>
<figcaption>
President Joe Biden (right) stands on the GMC Hummer EV production line as he tours the General Motors Factory ZERO electric vehicle assembly plant in Detroit, Michigan, on November 17, 2021. | Magdel Ngan/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
What supply-side liberals can learn from the past
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LwsG8f">
These days, political leaders and commentators talk often about “<a href="https://www.vox.com/policy/2023/4/5/23668755/industrial-policy-biden-chips">industrial policy</a>” and stimulating supply in the economy, rather than just demand. Whether it’s to spur new construction to tackle the nation’s affordable housing crisis, or decarbonize the country through <a href="https://www.vox.com/policy-and-politics/2022/7/28/23281757/whats-in-climate-bill-inflation-reduction-act">clean energy tax credits</a>, or pour subsidies into a <a href="https://www.vox.com/recode/2022/7/27/23277664/chips-act-solve-chip-shortage-biden-manufacturing">nascent US microchip sector</a>, policymakers have paid a lot more attention to the idea of government playing a more proactive role in private-sector development.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="H8cMoc">
But central to the debate over this idea known as “supply-side liberalism” is whether the government should attempt to do more on top of these efforts to stimulate businesses, like leveraging public subsidies to strengthen unions and environmental protections, or helping women and people of color access new jobs and opportunities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MMThN6">
Critics of this latter approach say a government that tries to do too much at once will inevitably <a href="https://www.nytimes.com/2023/04/02/opinion/democrats-liberalism.html">do nothing at all</a>, and that if we want a public sector that can actually deliver at scale, we’ll need to cut red tape, stay laser-focused on production, and resist pressure from clamoring interest groups. Others say bringing interest groups along and fighting for progressive goals while boosting industrial production is essential. “The answer is not a liberalism that builds, but a liberalism that builds power,” <a href="https://prospect.org/economy/2023-05-25-liberalism-that-builds-power/">argued</a> American Prospect<em> </em>editor David Dayen earlier this year, in an essay defending a more multifaceted approach, calling them “mutually reinforcing.” <a href="https://live-sas-www-history.pantheon.sas.upenn.edu/people/faculty/brent-cebul">Brent Cebul</a>, a professor of history at the University of Pennsylvania, offers some new perspective to this often intractable-seeming debate. The author of <a href="https://www.pennpress.org/9781512823813/illusions-of-progress/"><em>Illusions of Progress</em></a>, a book that traces earlier iterations of “supply-side liberalism” throughout the 20th century, Cebul argues that a government hoping to march forward on economic objectives under the belief it can circle back later to tackle social problems should expect to find those social problems in much worse shape. He thinks the key to doing both at once involves ensuring everyone can claim some semblance of victory.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0QTwuU">
Senior policy reporter Rachel Cohen talked with Cebul about his research and how Democrats interested in leveraging markets might avoid some of the mistakes of the past. Their conversation has been lightly edited and condensed for clarity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u3shZm">
—
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fh6PBT">
<strong>Rachel Cohen: </strong>Your book focuses on something you call “supply-side liberalism” — an idea you trace back to the 1930s. Can you briefly explain what you mean by the term?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LhE0Rc">
<strong>Brent Cebul: </strong>So “supply-side conservatism” is about cutting taxes and regulations in hopes that economic growth will trickle down. In broad strokes what I mean by “supply-side liberalism” is structuring markets to deliver social goods rather than the state delivering them directly itself. In the book, I walk through a handful of different ways in which, beginning in the New Deal, liberals sought to stimulate markets to ensure market activity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qZjqhM">
<strong>Rachel Cohen: </strong>Is that the same thing as “<a href="https://www.vox.com/the-big-idea/2017/7/18/15992226/neoliberalism-chait-austerity-democratic-party-sanders-clinton">neoliberalism</a>,” which people typically trace back to the 1970s? Or is it an earlier descendant?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Vb3oET">
<strong>Brent Cebul: </strong>So the way I think about its relationship to neoliberalism is the supply-side liberalism I write about was always embedded in a broader set of social aspirations that New Dealers and mid-century liberals pursued, that contained some more universal-style benefits, like Social Security. Eventually, in the 1960s, we get Medicare and Medicaid. Part of what I try to show in the book is that by the 1970s and 1980s, in the wake of the 1970s’ fiscal and political crises, a new generation of Democrats start using some of these same supply-side ideas to basically shear off some of the more progressive universal direct budget items.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="L66EBa">
The case that I use in the 1990s, in particular, is welfare. Bill Clinton <a href="https://www.vox.com/2016/6/20/11789988/clintons-welfare-reform">replaces Aid to Families with Dependent Children</a>, and takes the same money that would have gone to support mothers to instead subsidize businesses that hire people who are coming off welfare rolls. Part of what I try to show is that the logic and tools of Clinton’s policy are similar to the supply-side liberalism of the earlier 20th century, but the tools are turned back on the liberal state itself in an effort to drain the politics out of welfare.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GdcVBk">
<strong>Rachel Cohen: </strong>Today we have an emergent intellectual movement calling themselves supply-side liberals, or supply-side progressives, organizing around what they call an “<a href="https://www.theatlantic.com/ideas/archive/2022/01/scarcity-crisis-college-housing-health-care/621221/">abundance agenda</a>.” Led by people<a href="https://www.nytimes.com/2021/09/19/opinion/supply-side-progressivism.html"> like Vox co-founder Ezra Klein</a>, they’re calling for more housing, transit, more stuff in general, and say they want to help make democratic governments more effective and nimble. Do you see this movement as part of the same supply-side lineage you trace?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M25IN4">
<strong>Brent Cebul: </strong>I do think that they see a similar sort of market-sculpting role for government to play, and I think there’s a similar developmental pragmatism that defines both of these periods, which is making the best of what the constitutional federal structure will offer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g91338">
I think in both cases, there’s much to commend that outlook for in terms of recognizing the ways in which the government can actually play a remarkably innovative role in creating new markets. And what I think they recognize is that there are vast sectors of business that, despite all the ideological pronunciations against government and regulation, are absolutely happy to take subsidies. I think that’s actually a really crucial insight for liberalism in general, and just the rediscovery of the potential for partnerships between the liberal state and business is really promising.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ggxKgg">
<strong>Rachel Cohen: </strong>What lessons or historical advice would you give to this modern-day supply-side liberal movement? Are there any mistakes you think they should work to avoid or be mindful of?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VSyMMr">
<strong>Brent</strong> <strong>Cebul: </strong>Where they risk repeating the same kinds of mistakes as liberals going back to the New Deal is if they are less willing to impose certain types of progressive regulations along with those subsidies. The classic case recently is the resistance to using green subsidies, electric car subsidies, to stimulate union employment. My historical assumption is basically that if the subsidies are good enough, businesses will go along with that. And I think there’s a liberal tendency to sort of negotiate down before you’ve even had the hard conversation with the businesspeople or your opposition. And so the historical lesson from this is there’s been in the past an unwillingness to really include protections for minority constituencies in communities all across the country.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vhD1Qw">
I think liberals sell themselves short if they don’t demand more. One example I talk about at the end of my book is the number of businesses like Steris that received venture capital startup funds from the federal government and have now done things like tax inversions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9rA7pf">
<strong>Rachel Cohen: </strong>Can you say more about what you mean by demanding more?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aNRDM0">
<strong>Brent Cebul: </strong>One of the things that you often saw in the 1980s and ’90s with the neoliberal generation of Democrats is this sort of hard-nosed language around economic growth, that it’s more important than social values at the moment, and once we get our economic house in order then we’ll be able to deal with these downstream social issues. And surprise, it turns out they’re completely inextricable from each other. And if you only focus on the economic, then you’re largely going to entrench and worsen the social issues.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eaXjYs">
So they just have to be dealt with at the same time, and what I would say is that subsidizing economic growth actually gives the state leverage to pursue some of the social goals if they choose to take advantage of it. I think that’s precisely one of the things that the Roosevelt administration bumbled its way into. I don’t think it’s an accident that they were able to get a whole lot of their social programs through in the 1930s at a moment when all of these local Chambers of Commerce were also feeding at the trough of federal subsidies.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hlXBew">
<strong>Rachel Cohen: </strong>Your book is called <em>Illusions of Progress</em>. Can you talk about the title?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xz0XIA">
<strong>Brent Cebul: </strong>The illusion is that by putting businesspeople in the cockpit of momentous federal programs that you’re going to be able to deliver broader gains for the poor and the racially and socially marginalized.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bwN5YF">
<strong>Rachel Cohen: </strong>You describe how Black Americans started to demand “administrative enfranchisement” in new federal programs. Can you talk briefly about what happened?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7fXGEN">
<strong>Brent Cebul: </strong>Cities are so dependent on property values for property taxation, which is their lifeblood. So very early in the New Deal, urban governments started using the Public Works Administration, the Works Progress Administration, and the housing programs as an excuse to clear out what they viewed as “decadent communities” — meaning Black communities that didn’t have very high property values and were perceived as being a sort of net drain on city services. So under the aegis of the New Deal, and its subsidized labor programs, all these local governments started clearing Black neighborhoods, and as early as 1937 the NAACP and local Black political leaders are calling for a seat at the table to help determine how these really momentous federal programs are being handled at the local level.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lKwQBC">
What I tried to show is that protesting urban renewal was central to what the civil rights movement was up to, no matter where you look.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vFoL4y">
<strong>Rachel Cohen: </strong>So how do we go from that pursuit of “administrative enfranchisement” to where we are today, where it feels like powerful interests and lobbyists so often monopolize this community input process?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jVVuVZ">
<strong>Brent Cebul:</strong> What happens in the 1960s is totally fascinating, because the community action programs in the War on Poverty had this incredibly radical idea, which is what they call “maximum feasible participation” — that they’re going to allow local community groups to apply for federal community development funds, to do a whole range of things from opening community centers, to job training programs, to even, you know, opening a McDonald’s franchise in one case. But then marginalized community members start using it to protest local business, and people’s domination of the local political scene, and almost immediately the Lyndon Johnson administration moves to bring local businesspeople back in to lead these very programs. And so what I tried to show in the book is that the actual maximum feasible participation principle gets kneecapped really quickly.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RBeQZ2">
But the participatory principle itself sort of retains this sort of curious half-life, really up until today, where the federal government, local governments, and businesspeople learn that they need to have something that <em>looks and feels</em> like participation for marginalized people, but by the 1980s it’s really about managing their participation — getting them to buy in on various austerity measures by choosing where the cuts are going to be made, that sort of thing. So to your point, more mobilized interests have since been able to capitalize on those same practices and to actually implement their vision or block programs that they might otherwise not have been able to do without this “participation.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RTR0RO">
<strong>Rachel Cohen: </strong>After studying these periods, do you have any thoughts on how we can better bring in community participation or administrative enfranchisement without getting ensnared in the kind of co-optive politics and NIMBYism we see today?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wto9hy">
<strong>Brent Cebul: </strong>One of the things that I think Lyndon Johnson failed to do in the 1960s was to anticipate the blowback he was going to get for the community action program. As a result, he didn’t realize that it would have benefited him to buy off the local businesspeople by having a commensurate program for them. So one of the things I would urge modern-day supply-side liberals to do is to have as capacious a range of potential beneficiaries of any given program as possible, and to make sure that you’re being careful that there isn’t, you know, jealousy structured by the programs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0WZsne">
There’s obviously going to be competition and jealousy anyway, and there are going to be normative claims about who should and shouldn’t be getting federal aid and there are going to be scandals, but I think you could turn the temperature down on that if you’re willing to build a big enough bill and a big enough boat.
</p></li>
<li><strong>Black and Latino Americans haven’t experienced the same economy as everyone else</strong> -
<figure>
<img alt="President Joe Biden arrives to speak about his Bidenomics agenda at Tioga Marine Terminal in Philadelphia, Pennsylvania." src="https://cdn.vox-cdn.com/thumbor/C0r4Pcm22ewy9nW3QKKl5NZ_WQY=/869x0:7760x5168/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/72969219/1723099595.0.jpg"/>
<figcaption>
President Joe Biden arrives to speak about his Bidenomics agenda at Tioga Marine Terminal in Philadelphia, Pennsylvania. | Andrew Caballero-Reynolds / AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
For these families, the last few years’ economic tumult has been particularly pronounced.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oBeAn0">
Of all the difficult questions Democrats face ahead of 2024, two storylines are particularly confounding. The first is the <a href="https://www.vox.com/economy">economy</a>: Most Americans are still pretty pissed about its state, even though economists can point to plenty of positive indicators. And the second is in the polling: <a href="https://www.vox.com/joe-biden">Joe Biden</a> <a href="https://www.vox.com/2024-elections/23873568/biden-polling-black-latino-voters-2024-election-trump">continues to underperform</a> among Black and Latino Americans, who are a significant part of the Democratic base.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="paU1z3">
Those two features are likely connected. And understanding that connection might offer some greater insights into why today’s vibes remain so lousy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OBaNhC">
Those vibes are independent of whether the economy is “good” or “bad” in any objective sense. That’s a political hornet’s nest, particularly when Biden’s economic record will be front and center in 2024 — and it will likely matter less than how voters are feeling when they go to the polls. Some pundits argue that the sour feelings about the economy are a reflection of real-world conditions and lived experience, while others argue that it’s a perception issue, and that the economy is objectively lifting Americans’ fortunes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6yw8VY">
But not all Americans live under the same economic conditions, and <a href="https://www.pewresearch.org/race-ethnicity/2023/12/04/wealth-surged-in-the-pandemic-but-debt-endures-for-poorer-black-and-hispanic-families/">two</a> <a href="https://www.newyorkfed.org/medialibrary/Research/Interactives/Data/equitable-growth-indicators/downloads/10_2023_EGI_national_FULL">recent</a> reports shed light on the different economic experiences of Black and Latino Americans.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BMXIZc">
The news is, in short, a mixed bag. One study found that during the height of the <a href="https://www.vox.com/coronavirus-covid19">Covid-19 pandemic</a>, years that included the end of Trump’s term and the beginning of Biden’s, Black and Latino households made gains in accumulating wealth. But in the years that followed, those gains slowed significantly or even reversed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rLUi8z">
Part of that slide was due to inflation, the main economic villain of the Biden years. Another <a href="https://libertystreeteconomics.newyorkfed.org/2023/01/inflation-disparities-by-race-and-income-narrow/">2023 study</a> found that Black and Latino households suffered more from inflation than their white counterparts, as the higher costs of <a href="https://www.vox.com/transportation">transportation</a> and food took bigger bites out of their paychecks. But it’s not all bad news: There’s evidence that real wages — the value of workers’ pay when inflation is taken into account — grew for Black and Latino workers in recent years, and even that it grew faster for them than for workers overall.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YkoSyf">
Still, those silver linings do not seem like they’re putting Black and <a href="https://www.vox.com/politics/2023/5/4/23708278/joe-biden-kamala-harris-2024-election-latino-voters-julie-chavez-rodriguez">Latino voters</a> in a good mood about the nation’s economic environment. In <a href="https://www.nytimes.com/interactive/2023/11/07/us/elections/times-siena-battlegrounds-registered-voters.html">the New York Times’s surveys</a> of battleground states, Black voters, a loyal Democratic constituency, view the economy as negatively as white voters. And Latino voters viewed the economy more negatively than white voters in these states.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VhdGXW">
It’s worth breaking down these studies for answers on why that might be so.
</p>
<h3 id="WI79oB">
The early pandemic years saw Black and Latino families make economic gains
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FGzVUo">
Despite the initial shock of mass unemployment and fears about just how much lasting damage the Covid-19 pandemic would do to people of color in the US, it turns out that the worst of the pandemic years saw significant financial benefits for low-income and working-class Black and Latino families.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IQA4PH">
The clearest positive sign was an increase in wealth. The typical US household saw its <a href="https://www.federalreserve.gov/publications/changes-in-us-family-finances-from-2019-to-2022.htm">wealth increase</a> by about 37 percent from 2019 to 2022, even after adjusting for inflation, according to analysis from the Federal Reserve’s Board of Governors. Those are overall numbers, but a <a href="https://www.pewresearch.org/race-ethnicity/2023/12/04/wealth-gaps-within-racial-and-ethnic-groups/">recent report from the Pew Research Center</a> suggests that those gains in wealth were shared by the lowest-income Black and Latino households. (By “wealth,” Pew means net worth — or the sum of all the investments, property, and savings a family has, with debt subtracted from that figure.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FVlldW">
That greater wealth was born of a combination of factors. The job market recovered quickly after the economy began to open up, and competition for workers led to better wages for employees, who either got raises at their workplace or moved to better-paying jobs. Stocks and investments delivered better returns, while home values rose quickly. Families built up their savings during the pandemic, while the federal government gave out huge amounts of assistance. That help, which came in the form of direct stimulus payments, tax credits, or small business aid, was especially impactful for lower- and middle-income families.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u3kqAY">
The fact that low-income and working-class Black and Latino Americans saw their wealth increase during these years did not, by any stretch of the imagination, vault them into the upper class. The median low-income Black household, for example, was able to cut debt by about $6,000 — an improvement, but one that left them still in debt and with a negative net worth. The median low-income Latino household, meanwhile, was able to cut debt by about $1,000 and get itself out of debt. But even that growth meant achieving a net worth of zero.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UjMqkC">
And despite Black and Latino households gaining wealth during these years, the massive gap in actual wealth between Black and Hispanic families and white families actually grew. In 2019, the typical white household had $168,800 more in wealth than the typical Latino family, according to Pew. By 2021, that gap had grown by nearly $33,000.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fstgq4">
Even among Black and Latino households only, those pandemic gains were still uneven. Richer Black and Latino families still did better than poorer ones. And despite increases in wealth across both richer and poorer families, richer households still held the overwhelming majority of wealth going into 2022. This uneven recovery meant that those <a href="https://www.pewresearch.org/race-ethnicity/2023/12/04/wealth-gaps-within-racial-and-ethnic-groups/">who were already better off benefitted more</a> in absolute terms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sQof23">
But despite being uneven, the pandemic-era gains were still improvements. They were meaningful in getting families through a crisis and helping them improve their finances, even if for a brief moment. The next two years would bring more challenges, including some that would make many families, including Black and Latino households, feel like they were taking a step back.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HNZEn0">
Inflation picked up quickly starting in the second half of 2021, and many of the factors that contributed to the pandemic-era wealth boost either changed direction or became less favorable for all families. And incomes fell. As <a href="https://www.pewresearch.org/race-ethnicity/2023/12/04/wealth-surged-in-the-pandemic-but-debt-endures-for-poorer-black-and-hispanic-families/">Pew’s report notes</a>, after rising during the peak of the pandemic, the pre-tax income of US households then fell by 2.3 percent. After-tax income fell even more (8.8 percent), likely because federal stimulus payments stopped and tax breaks like the <a href="https://www.vox.com/future-perfect/2023/9/21/23882353/child-poverty-expanded-child-tax-credit-census-welfare-inflation-economy-data">expanded</a> child tax credit ended.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aXOGUA">
Meanwhile, <a href="https://apnews.com/article/spending-consumers-inflation-economy-growth-federal-reserve-b1d34bc43a0da960a152911b7c230881">spending remained high</a> as pandemic-era savings were used to offset inflation and address pent-up demand — which also slowly drained some of the wealth that had been accumulated, including by lower-income Black and Latino households, Pew notes. Home values, which had been increasing quickly in 2021, slowed down in 2022. And mortgage rates doubled as the Federal Reserve began responding to inflation.
</p>
<h3 id="p0Xj5J">
Inflation became a huge problem in 2021, especially for Black and Latino families
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M8vCgQ">
When talking about economic concerns, <a href="https://www.nytimes.com/2023/11/20/upshot/economy-voters-poll.html">Black</a> and <a href="https://unidosus.org/wp-content/uploads/2023/11/unidosus_national_surveyoflatinovoters.pdf">Latino</a> survey respondents in recent years are usually talking about inflation. And there’s good reason for this: Not everyone was affected by inflation in the same way. Inflation inequality — what the Federal Reserve Bank of New York calls the uneven rates of inflation experienced by different subgroups of Americans — got worse for Black and Latino families over the last two years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TguZQR">
New York Fed analysts did a <a href="https://libertystreeteconomics.newyorkfed.org/2023/01/inflation-disparities-by-race-and-income-narrow/">deep dive</a> into this question earlier this year, looking at the subcategories of spending that may have put greater strain on the <a href="https://www.vox.com/personal-finance">personal finances</a> of Asian American, Black, Latino, and white families. Using data from the Bureau of Labor Statistics — specifically, CPI numbers (which track inflation) and the Consumer Expenditure Survey (which tracks how subgroups spend their money) — the analysts found a stark difference in how inflation played out throughout 2021 and 2022.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Z5wKus">
Black and Latino Americans experienced “steadily higher price increases relative to the overall average between early 2021 and June 2022,” largely because of the way prices increased for transportation (specifically the price of cars and gasoline) and food. A few things explain this: larger families than white or Asian American households, different jobs that require different modes of transportation, and the kind of urban communities in which they live. But the evidence the analysts found is convincing: Black and Hispanic families spent a bigger portion of their paycheck on these more costly things than Asian American and white families did.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Bv0OAv">
Those disparities were biggest for Latinos when it came to spending on food, used cars, and gasoline, the <a href="https://libertystreeteconomics.newyorkfed.org/2023/01/inflation-disparities-by-race-and-income-narrow/">New York Fed analysts</a> found. And compared to white families, both Black and Latino families spent a bigger share of their paychecks on housing as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="d2EQGr">
As overall inflation rates have declined, these gaps have also shrunk, according to the New York Fed’s report. But they’re not entirely gone. And if you look at how inflation rates vary depending on income, you also see another disparity: For most of 2021 and 2022, it was middle-income families that felt the biggest crunch from inflation. But about halfway through 2022 and into 2023, the burden of inflation got worse for low-income families — which disproportionately tend to be Black and Latino households.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u1T6xL">
Into 2023, according to <a href="https://www.newyorkfed.org/medialibrary/Research/Interactives/Data/equitable-growth-indicators/downloads/10_2023_EGI_national_inflation">the New York Fed’s latest update</a>, those gaps still exist despite improvements. But Black and Latino families have also experienced another positive change in the last few years. Real wages, or the amount of money workers make after taking into account inflation, have steadily increased for Black and Latino workers since the pandemic’s onset, <a href="https://www.nber.org/system/files/working_papers/w31010/w31010.pdf">a November working paper</a> from the National Bureau of Economic Research (NBER) confirmed. Despite some volatility throughout the last couple of years, Black and Latino workers are making more money than they did before the pandemic. This matches <a href="https://www.nber.org/digest/20235/pandemic-related-shifts-low-wage-labor-markets">another trend</a> these NBER authors found earlier in the year: Real wages for the least-well-off workers, who disproportionately tend to be Black or Latino, have also been improving in the last two years. This is one reason why inflation isn’t a full picture of economic well-being. If wages (and other sources of income) remain higher than inflation, then households can still be better off — even if they’re paying higher sticker prices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ufTPfn">
That doesn’t mean, however, that people <em>feel</em> better off.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xwzvps">
In the New York Times poll, only 19 percent of Black voters and 14 percent of Latino voters had a generally positive view of the economy. (Twenty percent of white voters had a positive view.) Meanwhile, 48 percent of Black voters and 50 percent of Latino voters rated the economy as “poor.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0iHQE3">
While Black and Latino households have faced particular headwinds in recent years, and reaped fewer benefits from pandemic-era stimulus relative to already better-off white households, they’re not alone in feeling disgruntled: 52 percent of white voters rated the economy as “poor” in the same New York Times poll, more than either Black or Latino voters.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8jOMwj">
For the Democratic Party, however, the frustrations of voters of color should be sounding some particularly loud alarms with the <a href="https://www.vox.com/2024-elections">2024 election</a> on the horizon. For one, there’s a <a href="https://www.pewresearch.org/politics/2023/04/07/evaluations-of-the-economy-and-the-state-of-the-nation/">partisan gap in how voters feel about the economy</a>, and white voters make up a far larger share of the Republican electorate. And second, a turnout problem among voters of color, fueled by flagging economic satisfaction, would be a much bigger deal for Democratic candidates — including Joe Biden.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IgZNAo">
In other words, Democrats have a long way to go if they’re going to convince Black and Latino voters that today’s economy is anything to celebrate. And with election year approaching, they have relatively little time to do it.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kolkata 25K | Daniel Ebenyo and Sutume Kebede clinch titles with new World Best times</strong> - Sawan Barwal (1:17:49) and Reshma Kevate (1:30:38) recorded convincing wins among Indians</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Arshdeep Singh becomes first Indian pacer to take five-wicket haul against South Africa in ODIs</strong> - Arshdeep said that he was trying to keep things simple and it is great to open his wicket tally in ODIs with a five-wicket haul.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nathan Lyon celebrates 500 wickets as Australia thrash Pakistan by 360 runs</strong> - Lyon joined Shane Warne (708) and Glenn McGrath (563) among Australians with 500 wickets and become the eighth player overall</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SA vs IND first ODI | Arshdeep, Avesh star in emphatic Indian victory over South Africa</strong> - It seemed that Arshdeep (5/37 in 10 overs) and Avesh (4/27 in 8 overs) had picked up a cue from their seniors Mohammed Shami and Jasprit Bumrah</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Morning Digest | Parliament security breach: Raising voice against unemployment is not treason, says ‘mastermind’ Lalit Jha’s father; Kamal Nath removed as Madhya Pradesh Congress chief, and more</strong> - Here is a select list of stories to start the day</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Proposal to name Navi Mumbai airport after D B Patil likely to get Centre’s nod soon: Minister</strong> - Mr. Patil said the name of the new airport will be confirmed at the last stage of its construction</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“Look beyond the binary of public and private spaces to battle discrimination in terms of gender, disability and caste”: CJI</strong> - Justice Chandrachud elaborated on the need to make courts across the country disabled friendly</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Second home-built 700 MW nuclear plant at Kakrapar achieves first criticality</strong> - This sets the stage for its gradual move towards producing electricity for commercial purposes.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exercise Astrashakti: Indian Akash air defence missile system destroys 4 targets simultaneously</strong> - India has become the first to demonstrate the capability of engaging four targets simultaneously at such ranges by command guidance using a single firing unit</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kerala’s Shaikh Hassan Khan now scales Mount Vinson in Antarctica</strong> -</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cardinal Becciu: Vatican court convicts former Pope adviser of financial crimes</strong> - Italian cardinal Angelo Becciu is sentenced to five-and-a-half years in jail for financial crimes.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Alex Batty: British teen found in France returns to UK</strong> - Alex Batty, who was missing for six years, has returned to the UK, Greater Manchester Police says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>More big shipping firms stop Red Sea routes after attacks</strong> - MSC, the world’s largest shipping group, becomes the fourth company to divert ships following attacks.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How a Dutch tragedy made people take loneliness seriously</strong> - After a Dutch woman’s body was found 10 years after she died, politicians pushed to tackle loneliness.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Notre-Dame Cathedral spire gets new rooster weathervane ahead of 2024 reopening</strong> - The rooster - a French national symbol - replaces one damaged in the fire that ravaged the cathedral in 2019.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Here’s how an off-road racing series will make its own hydrogen fuel</strong> - Extreme E, the electric off-road series, is switching to hydrogen in 2025. - <a href="https://arstechnica.com/?p=1991074">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>This “smoking gun” killed the McDonald’s ice cream hackers’ startup</strong> - Three-year-old email shows evidence of plot to undermine repair business. - <a href="https://arstechnica.com/?p=1991363">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A top-secret Chinese spy satellite just launched on a supersized rocket</strong> - This satellite may carry a large telescope to continuously monitor the Indo-Pacific. - <a href="https://arstechnica.com/?p=1991612">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Marketer sparks panic with claims it uses smart devices to eavesdrop on people</strong> - “Real-time” listening claims were exaggerated, but the creepy factor remains. - <a href="https://arstechnica.com/?p=1991469">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Pixel 9 might come with exclusive “Pixie” AI assistant</strong> - What will happen to the Google Assistant when the new AI assistant comes out? - <a href="https://arstechnica.com/?p=1991507">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<script>AOS.init();</script></body></html>

4
index.html
View File

File diff suppressed because one or more lines are too long