diff --git a/archive-covid-19/14 January, 2024.html b/archive-covid-19/14 January, 2024.html new file mode 100644 index 0000000..ad9713a --- /dev/null +++ b/archive-covid-19/14 January, 2024.html @@ -0,0 +1,181 @@ + +
+ + + ++Background: Detecting and foreseeing pathogen dispersion is crucial in preventing widespread disease transmission. Human mobility is a critical issue in human transmission of infectious agents. Through a mobility data-driven approach, we determined municipalities in Brazil that could make up an advanced sentinel network, allowing for early detection of circulating pathogens and their associated transmission routes. Methods: We compiled a comprehensive dataset on intercity mobility spanning air, road, and waterway transport, and constructed a graph-based representation of Brazil9s mobility network. The Ford-Fulkerson algorithm, coupled with centrality measures, were employed to rank cities according to their suitability as sentinel hubs. Findings: Our results disentangle the complex transportation network of Brazil, with flights alone transporting 79.9 million (CI 58.3 to 10.1 million) passengers annually during 2017-22, seasonal peaks occurring in late spring and summer, and roadways with a maximum capacity of 78.3 million passengers weekly. We ranked the 5,570 Brazilian cities to offer flexibility in prioritizing locations for early pathogen detection through clinical sample collection. Our findings are validated by epidemiological and genetic data independently collected during the SARS-CoV-2 pandemic period. The mobility-based spread model defined here was able to recapitulate the actual dissemination patterns observed during the pandemic. By providing essential clues for effective pathogen surveillance, our results have the potential to inform public health policy and improve future pandemic response efforts. Interpretation: Our results unlock the potential of designing country-wide clinical sample collection networks using data-informed approaches, an innovative practice that can improve current surveillance systems. +
++The prevalence of COVID-19 critical illness varies across ethnicities, with recent studies suggesting that genetic factors may contribute to this variation. The aim of this study was to investigate natural selection signals of genes associated with critically-ill COVID-19 in sub-Saharan Africans. Severe COVID-19 SNPs were obtained from the HGI website. Selection signals were assessed in 661 sub-Sahara Africans from 1000 Genomes Project using integrated haplotype score (iHS), cross-population extended haplotype homozygosity (xpEHH), and fixation index (Fst). Allele frequency trajectory analysis of ancient DNA samples were used to validate the existing of selection in sub-Sahara Africans. We also used Mendelian randomization to decipher the correlation between natural selection and critically-ill COVID-19. We identified that CCR3 exhibited significant natural selection signals in sub-Sahara Africans. Within the CCR3 gene, rs17217831-A showed both high iHS (Standardized iHS = 2) and high XP-EHH (Standardized XP-EHH = 2.5) in sub-Sahara Africans. Allele frequency trajectory of CCR3 rs17217831-A revealed natural selection occurring in the recent 1,500 years. Natural selection resulted in increased CCR3 expression in sub-Sahara Africans. Mendelian Randomization provided evidence that increased blood CCR3 expression and eosinophil counts lowered the risk of critically ill COVID-19. Our findings suggest that sub-Saharan Africans are less vulnerable to critically ill COVID-19 due to natural selection and identify CCR3 as a potential novel therapeutic target. +
++Background: Long COVID (LC) is a complex and multisystemic condition marked by a diverse range of symptoms, yet its associated risk factors remain poorly defined. Methods: Leveraging data from the 2022 Behavioral Risk Factor Surveillance System (BRFSS) and National Health Interview Survey (NHIS), both representative of the United States population, this study aimed to identify demographic characteristics associated with LC. The sample was restricted to individuals aged 18 years and older who reported a positive COVID-19 test or doctor9s diagnosis. We performed a descriptive analysis comparing characteristics between participants with and without LC. Furthermore, we developed multivariate logistic regression models on demographic covariates that would have been valid at the time of the COVID-19 infection. Results: Among the 124,313 individuals in BRFSS and 10,131 in the NHIS reporting either a positive test or doctor9s diagnosis for COVID-19 (Table), 26,783 (21.5%) in BRFSS and 1,797 (17.1%) in NHIS reported LC. In the multivariate logistic regression model, we found middle age, female gender, Hispanic ethnicity, lack of a college degree, and residence in non-metropolitan areas associated with higher risk of LC. Notably, the initial severity of acute COVID-19 was strongly associated with LC risk. In contrast, significantly lower ORs were reported for Non-Hispanic Asian and Black Americans compared to Non-Hispanic White. Conclusions: In the United States, there is marked variation in the risk of LC by demographic factors and initial infection severity. Further research is needed to understand the underlying cause of these observations. +
++Background: By March 2023, 54 countries, areas and territories (thereafter âCATâ) reported over 2.2 million coronavirus disease 2019 (COVID-19) deaths to the World Health Organization (WHO) Regional Office for Europe (1). Here, we estimate how many lives were directly saved by vaccinating adults in the Region, from December 2020 through March 2023. Methods: We estimated the number of lives directly saved by age-group, vaccine dose and circulating Variant of Concern (VOC) period, both regionally and nationally, using weekly data on COVID-19 mortality and COVID-19 vaccine uptake reported by 34 CAT, and vaccine effectiveness (VE) data from the literature. We calculated the percentage reduction in the number of expected and reported deaths. Findings: We found that vaccines reduced deaths by 57% overall (CAT range: 15% to 75%), representing ~1.4 million lives saved in those aged â„25 years (range: 0.7 million to 2.6 million): 96% of lives saved were aged â„60 years and 52% were aged â„80 years; first boosters saved 51%, and 67% were saved during the Omicron period. Interpretation: Over nearly 2.5 years, most lives saved by COVID-19 vaccination were in older adults by first booster dose and during the Omicron period, reinforcing the importance of up-to-date vaccination among these most at-risk individuals. Further modelling work should evaluate indirect effects of vaccination and public health and social measures. +
++Adverse effects of COVID-19 on perinatal health have been documented, however there is a lack of research that separates individual disease from other changing risks during the pandemic period. We linked California statewide birth and hospital discharge data for 2019-2020, and compared health indicators among 3 groups of pregnancies: [a] 2020 delivery with COVID-19, [b] 2020 delivery with no documented COVID-19, and [c] 2019 pre-pandemic delivery. We aimed to quantify the links between COVID-19 and perinatal health, separating individual COVID-19 disease (a vs b) from the pandemic period (b vs c). We examined the following health indicators: preterm birth, hypertensive disorders of pregnancy, gestational diabetes mellitus and severe maternal morbidity. We applied model based standardization to estimate âaverage effect of treatment on the treatedâ risk differences (RD), and adjusted for individual and community-level confounders. Among pregnancies in 2020, those with COVID-19 disease had higher burdens of preterm birth (RD[95% confidence interval (CI)]=2.8%[2.1,3.5]), hypertension (RD[95% CI]=3.3%[2.4,4.1]), and severe maternal morbidity (RD[95% CI]=2.3%[1.9,2.7]) compared with pregnancies without COVID-19 (a vs b) adjusted for confounders. Pregnancies in 2020 without COVID-19 had a lower burden of preterm birth (RD[95% CI]=-0.4%[-0.6,-0.3]), particularly spontaneous preterm, and a higher burden of hypertension (RD[95% CI]=1.0%[0.9,1.2]) and diabetes RD[95%CI]=0.9%[0.8,1.1] compared with pregnancies in 2019 (b vs c) adjusted for confounders. Protective associations of the pandemic period for spontaneous preterm birth may be explained by socioenvironmental and behavioral modifications, while increased maternal conditions may be due to stress and other behavioral changes. To our knowledge, our study is the first to distinguish between individual COVID-19 disease and the pandemic period in connection with perinatal outcomes. +
++Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology. Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naĂŻve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-ÎČ and CNTF, among soluble analytes. Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement. +
++Background & objectives: Genomic surveillance of positive SARS-CoV-2 samples is important to monitor the genetic changes occurring in virus, this was enhanced after the WHO designation of XBB.1.16 as a variant under monitoring in March 2023. From 5th February till 6th May 2023 all positive SARS-CoV-2 samples were monitored for genetic changes. Methods: A total of 1757 samples having Ct value <25 (for E and ORF gene) from different districts of Rajasthan were processed for Next Generation sequencing (NGS). The FASTA files obtained on sequencing were used for lineage determination using Nextclade and phylogenetic tree construction. Results and discussion: Sequencing and lineage identification was done in 1624 samples. XBB.1.16 was the predominant lineage in 1413(87.0%) cases while rest was other XBB (207, 12.74%) and other lineages (4, 0.2%). Of the 1413 XBB.1.16 cases, 57.47% were males and 42.53% were females. Majority (66.53%) belonged to 19-59 year age. 84.15% of XBB.1.16 cases were infected for the first time. Hospitalization was required in only 2.2% cases and death was reported in 5 (0.35%) patients. Most of the cases were symptomatic and the commonest symptoms were fever, cough and rhinorrhoea. Co-morbidities were present in 414 (29.3%) cases. Enhanced genomic surveillance helped to rapidly identify the spread of XBB variant in Rajasthan. This in turn helped to take control measures to prevent spread of virus and estimate public health risks of the new variant relative to the previously circulating lineages. XBB variant was found to spread rapidly but produced milder disease. +
+Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction - Conditions: Long Haul COVID-19; Post-Acute COVID-19 Syndrome; Anosmia; Olfaction Disorders
Interventions: Drug: Sodium Citrate; Drug: Normal Saline; Other: Olfactory Training Kit - âThe Olfactory Kit, by AdvancedRxâ
Sponsors: University of North Carolina, Chapel Hill
Recruiting
Phase II, Double Blind, Randomized Trial of CX-4945 in Viral Community Acquired Pneumonia - Conditions: Community-acquired Pneumonia; SARS-CoV-2 -Associated Pneumonia; Influenza With Pneumonia
Interventions: Drug: CX-4945 (SARS-CoV-2 domain); Drug: Placebo (SARS-CoV-2 domain); Drug: CX-4945 (Influenza virus domain); Drug: Placebo (Influenza virus domain)
Sponsors: Senhwa Biosciences, Inc.
Not yet recruiting
Edge AI-deployed DIGItal Twins for PREDICTing Disease Progression and Need for Early Intervention in Infectious and Cardiovascular Diseases Beyond COVID-19 - Investigation of Biomarkers in Dermal Interstitial Fluid - Conditions: Heart Failure
Interventions: Device: Use of the PELSA System for dISF extraction
Sponsors: Charite University, Berlin, Germany
Not yet recruiting
Phase III Clinical Study Evaluating the Efficacy and Safety of WPV01 in Patients With Mild/Moderate COVID-19 - Conditions: Mild to Moderate COVID-19
Interventions: Drug: WPV01; Drug: Placebo
Sponsors: Westlake Pharmaceuticals (Hangzhou) Co., Ltd.
Recruiting
Integrated Mindfulness-based Health Qigong Intervention for COVID-19 Survivors and Caregivers - Conditions: COVID-19 Infection
Interventions: Other: Mindfulness-based Health Qigong Intervention
Sponsors: The Hong Kong Polytechnic University
Recruiting
Effect of Aerobic Exercises Versus Incentive Spirometer Device on Post-covid Pulmonary Fibrosis Patients - Conditions: Lung Fibrosis Interstitial; Post-COVID-19 Syndrome
Interventions: Other: Aerobic Exercises; Device: Incentive Spirometer Device; Other: Traditional Chest Physiotherapy
Sponsors: McCarious Nahad Aziz Abdelshaheed Stephens; Cairo University
Active, not recruiting
SARS-CoV-2 and Influenza A/B in Point-of-Care and Non-Laboratory Settings - Conditions: SARS-CoV-2 Infection; Influenza A; Influenza B
Interventions: Diagnostic Test: Aptitude Medical Systems Metrix COVID/Flu Test
Sponsors: Aptitude Medical Systems; Biomedical Advanced Research and Development Authority
Recruiting
Can Doctors Reduce COVID-19 Misinformation and Increase Vaccine Uptake in Ghana? A Cluster-randomised Controlled Trial - Conditions: COVID-19
Interventions: Behavioral: Motivational Interviewing, AIMS; Behavioral: Facility engagement
Sponsors: London School of Economics and Political Science; Innovations for Poverty Action; Ghana Health Services
Not yet recruiting
Long COVID Ultrasound Trial - Conditions: Long Covid
Interventions: Device: Splenic Ultrasound
Sponsors: SecondWave Systems Inc.; University of Minnesota; MCDC (United States Department of Defense)
Recruiting
Immunogenicity After COVID-19 Vaccines in Adapted Schedules - Conditions: Coronavirus Disease 2019; COVID-19
Interventions: Drug: BNT162b2 30”g; Drug: BNT162b2 20”g; Drug: BNT162b2 6”g; Drug: mRNA-1273 100”g; Drug: mRNA-1273 50”g; Drug: ChAdOx1-S [Recombinant]
Sponsors: Universiteit Antwerpen
Completed
Massively parallel profiling of RNA-targeting CRISPR-Cas13d - CRISPR-Cas13d cleaves RNA and is used in vivo and for diagnostics. However, a systematic understanding of its RNA binding and cleavage specificity is lacking. Here, we describe an RNA Chip-Hybridized Association-Mapping Platform (RNA-CHAMP) for measuring the binding affinity for > 10,000 RNAs containing structural perturbations and other alterations relative to the CRISPR RNA (crRNA). Deep profiling of Cas13d reveals that it does not require a protospacer flanking sequence but is exquisitelyâŠ
Human conjunctiva organoids to study ocular surface homeostasis and disease - The conjunctival epithelium covering the eye contains two main cell types: mucus-producing goblet cells and water-secreting keratinocytes, which present mucins on their apical surface. Here, we describe long-term expanding organoids and air-liquid interface representing mouse and human conjunctiva. A single-cell RNA expression atlas of primary and cultured human conjunctiva reveals that keratinocytes express multiple antimicrobial peptides and identifies conjunctival tuft cells. IL-4/-13âŠ
Inactivation mechanism of cold plasma combined with 222 nm ultraviolet for spike protein and its application in disinfecting of SARS-CoV-2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible virus that has precipitated a worldwide pandemic of coronavirus disease since 2019. Developing an effective disinfection strategy is crucial to prevent the risk of surface cross-contamination by SARS-CoV-2. This study employed pseudovirus and the receptor-binding domain (RBD) protein of SARS-CoV-2 as models to investigate the spike protein inactivation process and its underlying mechanisms using a novelâŠ
Role of TNF-α in the Pathogenesis of Migraine - CONCLUSION: To this end, TNF-α plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy.
TXM peptides inhibit SARS-CoV-2 infection, syncytia formation, and lower inflammatory consequences - After three years of the SARS-CoV-2 pandemic, the search and availability of relatively low-cost benchtop therapeutics for people not at high risk for a severe disease are still ongoing. Although vaccines and new SARS-CoV-2 variants reduce the death toll, the long COVID-19 along with neurologic symptoms can develop and persist even after a mild initial infection. Reinfections, which further increase the risk of sequelae in multiple organ systems as well as the risk of death, continue to requireâŠ
Natural flavonoid pectolinarin computationally targeted as a promising drug candidate against SARS-CoV-2 - Coronavirus disease-2019 (COVID-19) has become a global pandemic, necessitating the development of new medicines. In this investigation, we identified potential natural flavonoids and compared their inhibitory activity against spike glycoprotein, which is a target of SARS-CoV-2 and SARS-CoV. The target site for the interaction of new inhibitors for the treatment of SARS-CoV-2 has 82% sequence identity and the remaining 18% dissimilarities in RBD S1-subunit, S2-subunit, and 2.5% others. MolecularâŠ
Structure-based Virtual Screening from Natural Products as Inhibitors of SARS-CoV-2 Spike Protein and ACE2-h Receptor Binding and their Biological Evaluation In vitro - CONCLUSION: Compound B-8 can be used as a scaffold to develop new and more efficient antiviral drugs.
Lipid Metabolism Modulation during SARS-CoV-2 Infection: A Spotlight on Extracellular Vesicles and Therapeutic Prospects - Extracellular vesicles (EVs) have a significant impact on the pathophysiological processes associated with various diseases such as tumors, inflammation, and infection. They exhibit molecular, biochemical, and entry control characteristics similar to viral infections. Viruses, on the other hand, depend on host metabolic machineries to fulfill their biosynthetic requirements. Due to potential advantages such as biocompatibility, biodegradation, and efficient immune activation, EVs have emerged asâŠ
FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-ÎČ Expression through Regulating IRF-3 - SARS-CoV-2 triggered the global COVID-19 pandemic, posing a severe threat to public health worldwide. The innate immune response in cells infected by SARS-CoV-2 is primarily orchestrated by type I interferon (IFN), with IFN-ÎČ exhibiting a notable inhibitory impact on SARS-CoV-2 replication. FHL2, acting as a docking site, facilitates the assembly of multiprotein complexes and regulates the transcription of diverse genes. However, the association between SARS-CoV-2 and FHL2 remains unclear. InâŠ
Comparative Analysis of Cyclization Techniques in Stapled Peptides: Structural Insights into Protein-Protein Interactions in a SARS-CoV-2 Spike RBD/hACE2 Model System - Medicinal chemistry is constantly searching for new approaches to develop more effective and targeted therapeutic molecules. The design of peptidomimetics is a promising emerging strategy that is aimed at developing peptides that mimic or modulate the biological activity of proteins. Among these, stapled peptides stand out for their unique ability to stabilize highly frequent helical motifs, but they have failed to be systematically reported. Here, we exploit chemically diverse helix-inducing i,âŠ
Computer-Aided Prediction of the Interactions of Viral Proteases with Antiviral Drugs: Antiviral Potential of Broad-Spectrum Drugs - Human society is facing the threat of various viruses. Proteases are promising targets for the treatment of viral infections. In this study, we collected and profiled 170 protease sequences from 125 viruses that infect humans. Approximately 73 of them are viral 3-chymotrypsin-like proteases (3CL^(pro)), and 11 are pepsin-like aspartic proteases (PAPs). Their sequences, structures, and substrate characteristics were carefully analyzed to identify their conserved nature for proposing aâŠ
Viral Targeting of Importin Alpha-Mediated Nuclear Import to Block Innate Immunity - Cellular nucleocytoplasmic trafficking is mediated by the importin family of nuclear transport proteins. The well-characterized importin alpha (IMPA) and importin beta (IMPB) nuclear import pathway plays a crucial role in the innate immune response to viral infection by mediating the nuclear import of transcription factors such as IRF3, NFÎșB, and STAT1. The nuclear transport of these transcription factors ultimately leads to the upregulation of a wide range of antiviral genes, including IFN andâŠ
5â-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2â-O-methyltransferases - Viral RNA cap 2â-O-methyltransferases are considered promising therapeutic targets for antiviral treatments, as they play a key role in the formation of viral RNA cap-1 structures to escape the host immune system. A better understanding of how they interact with their natural substrates (RNA and the methyl donor SAM) would enable the rational development of potent inhibitors. However, as few structures of 2â-O-MTases in complex with RNA have been described, little is known about substrateâŠ
Correction to: Dihydroisocoumarins of Hydrangea macrophylla var. thunbergii inhibit binding of the SARS-CoV-2 spike protein to ACE2 - No abstract
Gut microbiota-derived butyrate promotes coronavirus TGEV infection through impairing RIG-I-triggered local type I interferon responses via class I HDAC inhibition - Swine enteric coronaviruses (SECoVs) infection in vivo alters the composition of short-chain fatty acids (SCFAs)-producing gut microbiota, but whether microbiota-derived SCFAs impact coronavirus gastrointestinal infection is largely unknown. Here, we demonstrated that SCFAs, particularly butyrate, substantially increased alphacoronavirus TGEV infection at the late stage of infection, without affecting viral attachment or internalization. Furthermore, enhancement of TGEV by butyrate depended onâŠ
The Elusive Promise of a Real 2024 Republican Race Against Donald Trump - On the Nikki Haley scenario and the eternal optimism of a New Year. - link
How the Biden Administration Defends Its Israel Policy - Isaac Chotiner interviews John Kirby, the strategic-communications coördinator for the National Security Council, about the Biden Administrationâs policy on Israel. - link
Did Nikki Haley Lose Her Nerve? - The former U.N. Ambassador has been gaining ground on Donald Trump. But, at the fifth Republican debate, she remained stuck in a race for second place. - link
The Deadly Challenges of War Coverage in Gaza - Clarissa Ward, the first Western reporter to enter Gaza without an I.D.F. escort since October 7th, has faced accusations of pro-Israel bias even as she strives to highlight Arab suffering. - link
How Israelâs Inspection Process Is Obstructing Aid Delivery - Senator Chris Van Hollen describes what he witnessed on the Egypt-Gaza border. - link
+How plagiarism became the latest weapon in the culture wars. +
++Plagiarism accusations are being wielded like weapons right now â and the multi-headed plagiarism controversy involving Claudine Gay, Bill Ackman and his wife, and Business Insider is a particularly bizarre one. +
++It began with Gay, who stepped down from her position as Harvardâs president, ostensibly because critics found instances of (real) plagiarism in her work, but really because people didnât like her congressional testimony on antisemitism at Harvard. Shortly thereafter, Business Insider published accusations of plagiarism against designer and former MIT professor Neri Oxman. Oxman is married to Bill Ackman, a major Harvard donor who vocally participated in a public campaign led by right-wing activists against Gay. Ackman, in response, announced that he would be launching his own plagiarism investigation into every person currently serving on MITâs faculty, administration, and board. +
++[Related: The culture war came for Claudine Gay â and isnât done yet] +
++Very few people involved in the mudslinging seem to cherish longstanding commitments to academic integrity, but they are more than willing to act as though they care about plagiarism a lot â or, alternatively, that plagiarism is no big deal â when it serves their political purposes. +
++As this latest battle of our neverending culture wars rages, itâs worth taking a step back and looking at some basic principles. Why is plagiarism a big deal? What does it mean to argue about it? +
++What even is plagiarism, anyway? +
++Weâll start with a basic working definition. +
++âPlagiarism is the use of someone elseâs words or ideas without giving them credit,â says Susan Blum, an anthropology professor at Notre Dame and the author of My Word! Plagiarism and College Culture. âBut when you actually operationalize, thatâs where this slipperiness comes in.â +
++Most people agree that itâs straightforwardly plagiarism to copy and paste someone elseâs work whole cloth and slap your own name on it. Most people also agree that itâs plagiarism to copy someone elseâs sentences or phrases, whether weâre talking about a middle school essay, a doctoral dissertation, or a newspaper article. +
++But what happens if those phrases are clichĂ©s? What if theyâre definitions? What if theyâre widely accepted facts phrased in commonly used language? What if weâre not even talking about words but about a specific chord progression or a bit of software coding? It gets tricky fast. +
++âWe all think we are talking about the same thing when we say the word, âplagiarism,â but that isnât necessarily the case,â writes Sarah Eaton in a blog post. Eaton is an education professor at the University of Calgary who studies academic ethics. âFrom my research, I can say with certainty that there is no singular or universally accepted definition of plagiarism.â +
++One of the biggest variations we see in how people talk about plagiarism comes from the different conventions in different disciplines within academia. Blum says that after she published My Word in 2009, academics in quantitative fields like engineering would tell her that it was common in their areas for people to plagiarize large chunks of their literature reviews. In these disciplines, what counted was the originality of your own research, not the originality of your summary of other peopleâs research. +
++Blum found this shocking. If a substantial part of someoneâs work is expository, she says, âI would expect them â especially a professor â to follow the professional forms of citation.â +
++The distinction Blumâs engineer is making between plagiarizing your literature review, which he says doesnât matter, and plagiarizing your research, which he says does matter, echoes a larger distinction between how academics think about plagiarism and how many others, including journalists, think about plagiarism. +
++In journalism, itâs common for outlets to report on the same story, and they donât always credit the outlet that broke it in the first place. âYou canât claim to own the news,â says Rod Hicks, the director of ethics and diversity at the Society of Professional Journalists. +
++Hicks argues that, for a journalist, itâs hard to prove a plagiarism claim that doesnât involve someone using your language verbatim. For an academic, on the other hand, plagiarism claims are most serious when they involve stealing other peopleâs research and ideas. For what itâs worth, thatâs not what either Gay or Oxman have been accused of. Everyone agrees their ideas and research were original â itâs their words that werenât. +
++Meanwhile, thereâs also a widespread understanding that if you do enough nonfiction writing, youâll end up with some sort of error of attribution somewhere in your work. Ackman, who called plagiarism âvery seriousâ when talking about the charges against Gay, seemed to change his mind after his wife was accused of similar plagiarism. +
++âIt is a near certainty that authors will miss some quotation marks and fail to properly cite or provide attribution for another author on at least a modest percentage of the pages of their papers,â Ackman posted on X. âThe plagiarism of today can be best understood by comparison to spelling mistakes prior to the advent of spellcheck.â (In Ackmanâs analogy, the new spellchecks are the AI filters that can read for plagiarism.) +
++âI worked as a proofreader for a long time, and I have never seen something published without errors,â says Blum. âThereâs almost always some kind of error, especially in the bibliography. If youâre going to reduce all of professional writing ethics to something mechanical like this, you are bound to turn up a lot of instances of error.â +
++The fact that a certain number of errors are unavoidable does not mean that all academics accept the level of plagiarism Gay committed as normal. In an article for the Atlantic, Ian Bogost ran his own dissertation through iThenticate, one of the new AI plagiarism filters. The filter at first told Bogost that 74 percent of his dissertation was copied â but after Bogost went through each match in his similarity score, he found that most of them were from iThenticate comparing his dissertation to a book he wrote based on his dissertation. Once Bogost had eliminated the bogus errors, his similarity score went down to zero. +
++âDoes this imply that Gayâs record is unusual among professors? Not in and of itself,â Bogost wrote. âBut it does at least refute the case that this was nothing more than academic jaywalking, or, in its purest straw-man form, that everybody does it.â +
++Bogost is gesturing at one of the arguments that emerged on the left after Gay was accused of plagiarism: an argument over whether what Gay did was incredibly common and hence no big deal, or whether it was straightforward plagiarism that should be taken very seriously. +
++The split went all the way down to the sources from whom Gay copied. One of them, Gayâs old lab mate D. Stephen Voss, compared Gayâs infraction to âdriving fifty-seven miles per hour on a fifty-five-mile-per-hour highwayâ: technically against the rules, but nothing so egregious that it deserves outsized punishment. Meanwhile, Carol Swain, whose work was also copied by Gay, publicly called for Gay to be fired and announced she was considering her legal options. âI donât know what to make of the scores of black and white professors who have either redefined plagiarism or stated that Gayâs misappropriation of their work is fine and dandy with them,â Swain posted on X. +
++The debate here speaks to the murky way that the accusations against Gay emerged. Gay certainly copied from other people. But Christopher Rufo, the conservative activist who brought the accusations to light, is the same guy who stirred up the crusade against critical race theory, and he openly did so as part of a larger conservative battle against elite colleges. Under those circumstances, for the left to join the calls for Gay to step down could feel like playing into the hands of the right. On the other hand â well, she does seem to have plagiarized, whether you consider this case to be a technicality or not. So how do you handle that? +
++If history is our guide, the academy should respond in earnest. Blum points to the case of historian Doris Kearns Goodwin, who in 2002 was ousted from the Pulitzer board and from her position as a regular guest on PBS NewsHour over a plagiarism scandal. Goodwin blamed the problem on her habit of transcribing quotes out longhand from other sources and then getting confused when she assembled her notes into a book. +
++âShe was found guilty of forgetting the quotation marks around quotations,â says Blum. âBecause she was not following proper citation guidelines, she was punished. I mean, sheâs rehabilitated, itâs not fatal. But it was tangible.â +
++It seems almost accidental that Rufo and his right-wing allies went with plagiarism as their weapon of choice. +
++âAny activist campaign has three points of leverage: reputational, financial and political,â Rufo explained in a Wall Street Journal op-ed. âFor some institutions, one point of leverage is enough, but, for a powerful one such as Harvard, the âsqueezeâ must work across multiple angles.â The plagiarism accusations were just leverage that happened to be particularly easy to acquire. +
++Plagiarism accusations are easier to come by now because of the rise of AI plagiarism detectors, which make it easy to comb through decadesâ worth of text and compare it to a vast library of existing work. Ironically, those detectors themselves were built by what might be considered plagiarism. (âAs far as I can tell, [AI is] just stealing,â Fran Lebowitz told Vox in October.) +
++We know for sure that Open AIâs ChatGPT was trained on a vast corpus that apparently includes pirated texts. Multiple high-profile authors have now sued Open AI for copyright infringement, including Jonathan Franzen and George R.R. Martin. In December, the New York Times sued OpenAI as well, arguing that ChatGPT is responsible for the âunlawful copying and use of The Timesâs uniquely valuable works.â +
++This argument has persisted for a long time. In 2007, a group of students sued the early plagiarism detector Turnitin, alleging that it was plagiarizing their work. Turnitin, after all, works by archiving every student paper thatâs uploaded to run through its filter, and then it charges schools for the use of that archive. The students argued â unsuccessfully â that Turnitin was making money from their intellectual property without their permission. +
++Blum says that every era has its own panic about how innovations are endangering intellectual property. âWhen I first started looking into plagiarism, there was a lot of stuff about how students didnât have to go to the library anymore and copy things by hand. You could just scrape it off the internet and insert it,â she recalls. âThere was a lot of discomfort about this new technology.â +
++Word processing and Google, a lethal combination, made language infinitely copyable and plagiarism incredibly easy to do, both intentionally and accidentally. Academia had to alter the way it thought about plagiarism to keep pace with the new tools. It developed new tools of its own, like Turnitin, and started spending more time on classroom conversations about how serious plagiarism is. +
++Today, one of the great innovations of AIâs large language models like ChatGPT is that they have made text into something not just copyable but synthesizable. The technology of the moment is manipulating texts in ways with which our current ethical frameworks are not built to reckon. +
++We donât have precedents to tell us how to think about whether or not it is plagiarism to take every book ever written and use it to teach a neural network how to talk. We donât have blueprints for dealing with what it means for someone to be able to go through your entire lifeâs work with a fine-tooth comb in a matter of days. +
++Our systems arenât set up to deal with these problems, but these problems are also not going to go away. Our new tools are available to both good-faith and bad-faith actors, and that means we are at the beginning of a very messy new era indeed. +
+Beijing has branded incoming president Lai Ching-te a âtroublemakerâ for his pro-sovereignty stance. +
++Taiwanâs election results are in, and voters chose Lai Chiang-te in a three-way race as the candidate who best represented what theyâre looking for in a leader â that is, the status quo. +
++Lai, the current vice president and head of the ruling Democratic Progressive Party, declared victory Saturday with just over 40 percent of the vote, crowding out his opponents, Hou Yu-ih of the Kuomintang (KMT) and Ko Wen-je of the Taiwan Peopleâs Party. Itâs the first time in Taiwanâs democratic history that a political party has won a third term in office â and Lai has repeatedly told voters heâll preserve outgoing President Tsai Ing-wenâs policies to preserve Taiwanâs democratic system and its sovereignty. While we donât know what Chinaâs response will be or when it will happen, there is expectation among some China experts that it will be âassertiveâ. +
++Though Taiwanese voters have a variety of concerns â including economic and social priorities â the primary question in a presidential election is how each candidate will manage relations with China, which claims Taiwan as its own. Though Lai is not specifically calling for independence from the mainland, both his predecessorâs stance and some of his past comments in favor of independence have gotten him branded a âtroublemakerâ by Beijing. +
++The Chinese Communist Party has harbored the hope that Taiwan, where the nationalist Kuomintang fled following the Chinese civil war in 1949 and 1950, would unify with the mainland and accept CCP rule. Laiâs win means that goal â at least by peaceful means, under the islandâs own volition â is still quite far away, if it is to happen at all. +
++During Tsaiâs eight-year tenure, Taiwan asserted its independence from the mainland by strengthening its relationship with the US, to the ire of Chinese President Xi Jinping. Though the US was already Taiwanâs main security partner, more symbolic acts like former Speaker of the House Nancy Pelosiâs visit to the island in 2022 and Tsaiâs trip to the United States last April infuriated Beijing, which in both instances performed military drills in Taiwanâs vicinity and enacted punitive diplomatic measures. +
++Though China has not yet responded to Laiâs win, Beijing has said that the election was illegitimate, given that it sees Taiwan as part of the mainland. China also attempted to spread disinformation in favor of Hou, the KMT candidate, which it sees as more deferential to the mainland. +
++Lai won with only 40 percent of the vote, and the DPP has lost its parliamentary majority, indicating that voters feel some measure of frustration, likely regarding social issues like the economy and high cost of living. +
++Still, âI think the main headline is continuity over change,â Andrew Scobell, a distinguished fellow with the China program at the US Institute of Peace, told Vox. +
++What Laiâs win means for Taiwanâs standing in the world +
++Tsaiâs tenure saw the loss of some of the islandâs diplomatic allies â countries that had ties with Taipei rather than Beijing. Her 2023 trip to the Americas included stops not only in Washington, but in Latin American countries like Guatemala, too, in an attempt to protect those relationships from Beijingâs economic diplomacy. That policy has drawn Costa Rica, Panama, the Dominican Republic, El Salvador, and Nicaragua into Chinaâs diplomatic orbit over the past 16 years. +
++China has often engaged in economic coercion in some form or another, whether itâs to encourage cash-strapped Latin American and Caribbean nations to recognize Beijing, or to tacitly control important infrastructure in places like Sri Lanka. +
++Efforts to turn Taiwanâs remaining diplomatic allies are likely to continue under Lai â but so are Taiwanâs efforts to cultivate powerful friends. +
++Taiwan under Tsai shored up its relationship with the United States, as well as creating closer ties with Japan and European nations; all three candidates emphasized the importance of the US-Taiwan relationship, with little daylight on their foreign policy. +
++Where Lai broke away with his competitors, and particularly Hou, was in his framing of Fridayâs election as a choice âbetween democracy and autocracy,â as David Sacks, a fellow for Asia studies at the Council on Foreign Relations said in a panel discussion Wednesday. +
++All the candidates indicated that they would continue Taiwanâs defense partnership with the US and would would increase the islandâs defense budget, which currently stands at $19.1 billion, or 2.6 percent of GDP, indicating, as Sacks said, broad agreement that relying on dialogue with Beijing or Xiâs âgoodwillâ isnât enough to keep China from trying to take the island by force. While Lai signaled that heâll raise that percentage, itâs not yet clear by how much. +
++âThe Tsai administration has gotten much more serious about how Taiwan can best defend itself against China,â Scobell said. âTheyâre grappling with, âHow do we stop China from landing on Taiwan?â But if they end up getting there, thinking of how Taiwan can resist.â +
++Thatâs not to say that cross-strait dialogue is out of the question under Lai, Sacks said. +
++âItâs certainly not like he doesnât want dialogue with Beijing, he said that the door is open and heâs willing to talk on an equal footing.â However, âI donât think itâs unfair to say that his top priority is really strengthening ties to the United States, Japan, and other democracies. And cross-strait communication is something thatâs nice to have, but not something that you must have.â +
++Though foreign policy is important, itâs not the only issue voters care about +
++The economy and cost of living are also important to Taiwanese voters, though perhaps less so than the existential threat of war or takeover by China. +
++Taiwan is dealing with a serious real estate crunch, as Margaret Lewis, a law professor at Seton Hall who focuses on human rights in China and Taiwan, told Wednesdayâs panel. âYounger voters [are] more concerned about things like the price of housing,â Lewis said. âItâs very expensive to buy housing. So thereâs talk about sort of preferential loans to first-time homebuyers, especially under a certain age.â +
++Lai has pledged to increase the number of affordable housing units under the plan outlined by Tsai, as well as building new housing units and encouraging further participation in a government-sponsored subsidy program for landlords, according to Focus Taiwan. +
++Another problem is Taiwanâs sluggish economy; wages have failed to increase with the cost of living, and Chinaâs economic retribution â banning key exports and banning Chinese tourism to the island in an effort to both punish Taiwan and encourage residents to favor more dialogue and cooperation with the mainland â is likely to continue after Laiâs win. +
++Taiwan must also diversify its economy away from its focus on semiconductors, of which it is the worldâs largest manufacturer. As Voxâs Joshua Keating wrote earlier this month: +
++âThe worldâs reliance on these chips is so great that it has sometimes been called Taiwanâs âsilicon shield.â The idea is that the global economy, very much including China itself, is simply too reliant on Taiwan-made semiconductors to risk any action that might take the supply offline. But as the invasion of Ukraine has shown, countries can be willing to incur severe economic costs to accomplish what they see as major geopolitical goals â and reunification is about as fundamental as it gets for China.â +
++Ultimately, the economy is not just a domestic issue but a foreign policy and cross-strait issue, too â which points back to relations with China as Taiwanâs main concern. And Laiâs democratic and sovereignty bonafides are certain to garner an angry response from China, on multiple fronts. +
++Though Scobell predicts an âassertive responseâ to Laiâs win on Beijingâs side, he said itâs likely to happen in the coming weeks or months, not in the next few days. +
++âWeâre going to see a reaction from China; the question is, when and how,â Scobell said. âWhereas five, 10, 15 years ago, it was fairly predictable â the kinds of things that Beijing would do. But I think itâs increasingly difficult to predict what is going to happen and when itâs likely to happen.â +
+Itâs an escalation in the region, but weâre not actually headed to outright war with Iran. +
++The United States and the United Kingdom on Thursday night launched strikes against targets in Yemen used by Houthi rebels to antagonize the global shipping industry in the Red Sea, raising fears of further escalation of the simmering conflict in the Middle East over Israelâs war in Gaza. +
++The strikes, which were followed up by an additional, smaller salvo against a radar site Saturday, were the most significant action the US has taken against the Houthis â a militant group in control of much of northern Yemen, who are funded and trained by Iran, and who sympathize with the Palestinian cause â thus far. Their Red Sea operations, they say, are protesting Israelâs war in Gaza, which has killed more than 23,000 Palestinians so far. In other words, the US/UK strikes are both part of and responding to the ongoing regional conflict that has included operations like targeted US attacks in Iraq and Syria for months. And as Thursdayâs strikes demonstrate, that ongoing conflict shows little sign of slowing. +
++US officials said the airstrikes, as well as missiles launched from ships and at least one Tomahawk cruise missile launched from a submarine, hit 60 targets, including Houthi weapons depots, drone and missile launch sites, and radar outposts. âThese targets were very specifically selected for minimizing the risk of collateral damage,â a senior Pentagon official told reporters Thursday night. âWe were absolutely not targeting civilian population centers. We were going after very specific [capabilities] in very specific locations with precision munitions.â +
++Houthi attacks on commercial vessels have been ongoing since mid-November, and have had serious effects on global trade. They have successfully deterred shipping giants like Maersk from traveling through the Red Sea and Suez Canal, an important route for trade between Asia and Western countries. The group claims it only targets ships headed to or affiliated with Israel to protest that countryâs war in Gaza, though it seems to be abandoning that principle as the attacks continue. The Houthis have carried out at least 27 attacks since November 19, and though they donât typically cause casualties or damage, many companies have deemed the Red Sea route too risky and chosen to take the longer, more expensive route around Africaâs Cape of Good Hope, driving up prices for consumer goods. The US began threatening retaliatory strikes against the Houthis over the past week, after the group ignored a âfinal warningâ from the US, and continued its attacks on ships. +
++In addition to the UK, Australia, Bahrain, Canada, and the Netherlands also took part in coordinating the strikes, though their roles in the operation are not yet clear. But regional partners, including Saudi Arabia and the United Arab Emirates, expressed concern about maintaining stability in the region and the possibility that the situation could spiral even more out of control. Some within the US government, like Reps. Ro Khanna (D-CA) and Val Hoyle (D-OR) questioned the constitutionality of the move, and Jeremy Corbyn, former leader of the UKâs Labour Party, denounced it. The US Department of Defense has not yet released information about casualties and continues to assess the success of the strikes. The Houthis claim the attacks killed five of their troops and wounded six others. +
++The Houthis, for their part, have promised to retaliate, saying that âall US, UK interests have become âlegitimate targets.ââ And according to James Jeffrey, chair of the Middle East Program at the Wilson Center and former special envoy to the Global Coalition to Defeat ISIS, while Thursdayâs strikes hit some significant targets, âthey certainly didnât take down the Houthisâ ability to launch these attacks into the Red Sea.â +
++So while there might not be a risk of confrontation between the US and Iran, there are likely more â and potentially larger â tit-for-tat attacks to come. +
++While the strikes represent an escalation on the part of the US and its allies â marking a move from rhetoric to violence â they are unlikely to lead to a full-fledged war with the Houthis, or their sponsors in Iran, and may not change the reality on the water. The Houthis could continue to antagonize ships in the Red Sea, despite the known consequences, because they have much to gain by doing so â and little to lose, Jon Alterman, director of the Middle East Program at the Center for Strategic and International Studies, told Vox. +
++âItâs hard to [eliminate targets] that the Houthis find valuable,â he said. âYou can spend a lot of money trying to destroy some very cheap installations.â +
++Whatâs more, the US-led strike (and any future actions against the group) can be interpreted as the Houthis being elevated on the global stage, giving them a legitimacy and prestige they previously lacked. That symbolic victory is only strengthened by the perception among some supporters of Palestine and the Palestinian Islamic Jihad that the Houthis are the only force willing to take big risks on behalf of the Palestinian cause. âTheyâve become consequential when few other groups are, and theyâve done it from a pretty low base,â Alterman said. +
++A large part of the reason Thursdayâs strikes probably wonât lead to an all-out war with Iran, according to Ali Vaez, the Iran director at the International Crisis Group, is that âthere is only so far [Iranâs] command and control extend across its network.â Whereas Hezbollah in Lebanon is in lock-step with the Islamic Revolutionary Guard Corps, thereâs a spectrum of control that Iran has over its proxy groups. âIt has the least amount of control of the Houthis,â Vaez said. And with its actions in the Red Sea, the Houthis are establishing themselves on their own terms, âpainting themselves not as Iranian proxies,â Alterman said. +
++Iran has no appetite for an expanded conflict, Vaez said. But looking out over the wider region over the past week, itâs clear that lower-level conflict is already occurring on several fronts â in the Red Sea, in Lebanon, and in Iraq. So rather than Israelâs war in Gaza leading to a larger war between global and regional powers, it currently seems more likely the conflict could take the shape of âopen-ended hostilities that you canât find a reason to stop,â Alterman said. +
++Update, January 13, 11:27 am ET: This story has been updated to include details of further attacks by the US and UK. +
PAK vs NZ, 2nd T20I | New Zealand beats Pakistan by 21 runs, leads 5-match series 2-0 - Pakistan stumbled in the second half of its innings and was bowled out for 173 in the 20th over
Indian shooters pick up more gold in Jakarta - India has won 32 medals, making this tournament the countryâs successful outing in the continental tournament
Cascade and Scaramanga excel -
FIH defends its decision to legalise betting in hockey -
Australian Open tennis | Novak Djokovic launches bid for Grand slam history against qualifier - Womenâs second seed Aryna Sabalenka starts her own title defence in sunny Melbourne, while menâs fifth seed Andrey Rublev is also in action.
Rejuvenation of twin lakes near Katpadi will be completed in six months: Duraimurugan - Spread over 100 acres, the twin lakes are separated by a narrow channel. Each lake, on an average, can store 35 mcft of water.
Need united stand against Centreâs unfriendly policies, says K.N. Balagopal - Finance Minister welcomes Oppositionâs decision to accept CMâs invitation for talks on Monday
Maldives asks India to withdraw troops by March 15 - According to the latest government figures, there are 88 Indian military personnel in the Maldives
Sri City-based firm bags international award -
Karnataka government should not delay pensions for the old and needy: H.D. Kumaraswamy - The former Chief Minister cited a shocking incident where a senior citizen crawled for five km to seek her pension
Queen Margrethe: Will abdication cause a ripple effect? - Nordic monarchies are known to embrace modernity. Abdication was one of the few customs they resisted - until now.
Boris Akunin: Russia designates author âforeign agentâ - The Kremlin labels the bestselling author, Boris Akunin, a foreign agent over his stance on Ukraine.
Matteo Salvini: Italian deputy PM takes stand in migrant kidnap trial - Matteo Salvini said he acted âin the national interestâ by banning a rescue ship from docking in Italy.
Gabriel Attal: Youngest French PM hopes to revive Macronâs government - Franceâs youngest PM is already popular with the public but how long will the honeymoon period last?
Huge fire rips through warehouse in Russia - Hundreds of firefighters battled to put out the blaze at the Wildberries warehouse in St Petersburg.
Would Luddites find the gig economy familiar? - Luddites were hardly the anti-tech dullards historians have painted them to be. - link
CDC reports dips in flu, COVID-19, and RSVâthough levels still very high - The dips may be due to holiday lulls and CDC is monitoring for post-holiday increase. - link
Reddit must share IP addresses of piracy-discussing users, film studios say - Reddit says First Amendment rights protect it from having to disclose usersâ info. - link
The Space Force is changing the way it thinks about spaceports - Thereâs not much available real estate to grow Cape Canaveralâs launch capacity. - link
COVID shots protect against COVID-related strokes, heart attacks, study finds - Data provides more evidence older people should stay up to date on COVID vaccines. - link
An elementary school teacher is about to have a bottle of apple cider for his lunch, when one of his student comes running up to him. -
++âWould you mind pouring that bottle of cider into a bowl?â asks the little girl. âI got a thorn in my finger at recess.â +
++Confused, the teacher pours the cider into a bowl. The girl dips her hand into the cider, and screams. âOuch! The cider is making it worse!â +
++âWhy would you think dipping your hand into apple cider would make the pain go away?â asks the teacher. +
++âBecause,â says the girl, âlast weekend, when my sister came home from college, I overheard her saying that whenever she gets a prick in her hand, she canât wait to get it in cider!â +
+ submitted by /u/wimpykidfan37
[link] [comments]
Two Stormtroopers are standing watch, when one of them notices the other has a new iPhone. He asks why he bought an iPhone? -
++The other Stormtroopers replies " I couldnât the find the droid I was looking for" +
+ submitted by /u/4mla4speed
[link] [comments]
Watch out! -
++A father and his 7 yr. old son are standing in line at the bank. The little boy notices a rather large lady wearing a yellow raincoat in line of front of them. The boy tells his dad that lady is big as a truck, the father whispers to his son that it isnât nice to say that people are big. He asks the little boy to be nice. Just after he says this, the ladyâs pager goes off. The little boy screams out really loud. âWatch out - Dad - she is backing upâ . +
+ submitted by /u/4mla4speed
[link] [comments]
A foreign exchange student was caught masturbating furiously in the host coupleâs bed -
++Shocked and offended, the couple say to the kid âwe gave you a place to stay and this is what you do. And why couldnât you do it in your own room?â +
++The student replied â iâm sorry, i thought this is where we were supposed to do it since you kept calling it the masturbate roomâ +
+ submitted by /u/pyrolid
[link] [comments]
Why was the mole depressed -
++His life was boring. +
+ submitted by /u/MildlyJovian
[link] [comments]