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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Compliance Without Fear: Individual-Level Predictors of Protective Behavior During the First Wave of the COVID-19 Pandemic</strong> -
<div>
Objectives: The outbreak of the COVID-19 pandemic required rapid public compliance with advice from health authorities. Here, we ask who was most likely to do so during the first wave of the pandemic. Design: Quota-sampled cross-sectional and panel data from eight Western democracies (Denmark, France, Germany, Hungary, Italy, Sweden, UK and USA). Methods: We fielded online public opinion surveys to 26,508 citizens between March 19 and May 16. The surveys included questions about protective behavior, perceptions of the pandemic (threat and self-efficacy), as well as broader attitudes towards society (institutional and interpersonal trust). We employ multilevel and fixed-effects regression models to analyse the relationship between these variables. Results: Consistent with prior research on epidemics, perceptions of threat culturally uniform determinants of both avoidant and preventive forms of protective behavior. On this basis, authorities could foster compliance by appealing to fear of COVID-19, but there may be normative and practical limits to such a strategy. Instead, we find that another major source of compliance is a sense of self-efficacy. Using individual-level panel data, we find evidence that self-efficacy is amendable to change and exerts an effect on protective behavior. Furthermore, the effects of fear are small among those who feel efficacious, creating a path to compliance without fear. In contrast, two other major candidates for facilitating compliance from the social sciences, interpersonal trust and institutional trust, have surprisingly little motivational power during the first wave of the COVID-19 pandemic. Conclusions: To address future waves of the pandemic, health authorities should thus focus on facilitating self-efficacy in the public.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/uzwgf/" target="_blank">Compliance Without Fear: Individual-Level Predictors of Protective Behavior During the First Wave of the COVID-19 Pandemic</a>
</div></li>
<li><strong>The novel Artificial Neural Network assisted models: A review</strong> -
<div>
Neural networks are one of the methods of artificial intelligence. It is founded on an existing knowledge and capacity to learn by illustration of the biological nervous system. Neural networks are used to solve problems that could not be modeled with conventional techniques. A neural structure can be learned, adapted, predicted, and graded. The potential of neural network parameters is very strong prediction. The findings are more reliable than standard mathematical estimation models. Therefore, it has been used in different fields. This research reviews the most recent advancement in utilizing the Artificial neural networks. The reviewed studies have been extracted from Web of Science maintained by Clarivate Analytics in 2021. We find that among the other applications of ANN, the applications on Covid-19 are on the rise.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/kygnt/" target="_blank">The novel Artificial Neural Network assisted models: A review</a>
</div></li>
<li><strong>Imagining Personally-Relevant Outcomes Influences Perceived Risk of Viral Transmission for Older Adults</strong> -
<div>
The COVID-19 pandemic has created a serious and prolonged public-health emergency. Older adults have been at significantly greater risk of hospitalization, ICU admission, and death due to COVID-19; as of February 2021, over 81% of COVID-19-related deaths in the U.S. occurred for people over the age of 65. Converging evidence from around the world suggests that age is the most significant risk factor for severe COVID-19 illness and for the experience of adverse health outcomes. Therefore, effectively communicating health-related risk information requires tailoring interventions to older adults’ needs. Using a novel informational intervention with a nationally-representative sample of 546 U.S. residents, we found that older adults reported increased perceived risk of COVID-19 transmission after imagining a personalized scenario with social consequences. Although older adults tended to forget numerical information over time, the personalized simulations elicited increases in perceived risk that persisted over a 1-3 week delay. Overall, our results bear broad implications for communicating information about health risks to older adults, and suggest new strategies to combat annual influenza outbreaks.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/6m5p4/" target="_blank">Imagining Personally-Relevant Outcomes Influences Perceived Risk of Viral Transmission for Older Adults</a>
</div></li>
<li><strong>COVID-19 Pandemic, Personality and Geriatric Population: Proposed Pragmatism</strong> -
<div>
Elderly people are the most sensitive and delicate part of society who must bear the major burn of disruptive social behavior of human being amidst the 2019 coronavirus infectious disease (COVID-19) pandemic. Our aim was (1) to find out the root of disruption of societal integrity and self-centeredness by analyzing spokes of HEXACO; 2) to delineate its possible relationship with the formation of Neuroticism and eventually Psychopathy, and 3) to search for the potential ways to get rid of this darkness. Human civilization is experiencing unique psychosocial problems through emerging COVID 19. Depression, panic buying, herd behavior, yellow journalism, “infodemic” spreading through social media, immense sufferings of marginalized people, children and elderly, a surge of addictive behavior, racism, domestic violence, rape, divorce, financial constraints, and stigmatization, all possibly stem from a constellation of different negative human behaviors which probably originate from negative deflection of components of HEXACO model of personality towards the genesis of the dark triad. COVID-19 and surge of the dark triad in form of Neuroticism, Narcissism and Machiavellianism are causing major mental health threat. Cultivations and practice of positive emotions and triumph of honesty, humility and humanity are utmost desirable to save Earth and its habitants from the cruel claws of this pandemic.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/4d9pz/" target="_blank">COVID-19 Pandemic, Personality and Geriatric Population: Proposed Pragmatism</a>
</div></li>
<li><strong>Family Still Matters: Human Social Motivation during a Global Pandemic</strong> -
<div>
How have people’s fundamental social motives changed during the COVID-19 pandemic? In data collected from 32 countries before the onset of the pandemic, we saw that a) people prioritized family-related motives (romantic relationship maintenance and kin care) over mate-acquisition motives (mate-seeking and breakup concern), and b) family-related motives were positively associated with subjective well-being, whereas mate-acquisition motives were negatively associated with subjective well-being (Ko et al., 2020). Have the pandemic-related changes in people’s social lives affected the relative priority of family-related motives and their relationship with well-being? In data collected from 28 countries during the pandemic, we see that although, as expected, people’s disease avoidance motivation has increased, a) the relative prioritization of family-related motives over mate-acquisition motives remains unchanged, and b) family-related motives remain positively associated with well-being and mate-acquisition motives remain negatively associated.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/z7mjc/" target="_blank">Family Still Matters: Human Social Motivation during a Global Pandemic</a>
</div></li>
<li><strong>No Utilitarians in a Pandemic? Shifts in Moral Reasoning during the COVID-19 Global Health Crisis</strong> -
<div>
The COVID-19 pandemic poses many real-world moral dilemmas, which can pit the needs and rights of the many against the needs and rights of the few. We investigated the influence of this contemporary global crisis on moral judgments in older adults, who are at greatest personal risk from the pandemic. We hypothesized that during this pandemic, individuals would give fewer utilitarian responses to hypothetical dilemmas, accompanied by higher levels of confidence and emotion elicitation. Our pre-registered analysis (https://osf.io/g2wtp) involved two waves of data collection, before (2014) and during (2020) the COVID-19 pandemic, regarding three categories of moral dilemmas (personal rights, agent-centered permissions, and special obligations). While utilitarian responses considered across all categories of dilemma did not differ, participants during the 2020 wave gave fewer utilitarian responses to dilemmas involving personal rights; that is, they were less willing to violate the personal rights of others to produce the best overall outcomes.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/yjn3u/" target="_blank">No Utilitarians in a Pandemic? Shifts in Moral Reasoning during the COVID-19 Global Health Crisis</a>
</div></li>
<li><strong>Genome-Wide Covariation in SARS-CoV-2</strong> -
<div>
The SARS-CoV-2 virus causing the global pandemic is a coronavirus with a genome of about 30Kbase length (Song et al., 2019). The design of vaccines and choice of therapies depends on the structure and mutational stability of encoded proteins in the open reading frames (ORFs) of this genome. In this study, we computed, us-ing Expectation Reflection, the genome-wide covariation of the SARS-CoV-2 genome based on an alignment of {approx}130000SARS-CoV-2 complete genome sequences obtained from GISAID (Shu &amp; McCauley, 2017). We used this covariation to compute the Direct Information between pairs of positions across the whole genome, investigating potentially important relationships within the genome, both within each encoded protein and between encoded proteins. We then computed the covariation within each clade of the virus. The covariation detected recapitulates all clade determinants and each clade exhibits distinct covarying pairs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.08.434363v1" target="_blank">Genome-Wide Covariation in SARS-CoV-2</a>
</div></li>
<li><strong>AI-driven prediction of SARS-CoV-2 variant binding trends from atomistic simulations</strong> -
<div>
We present a novel technique to predict binding affinity trends between two molecules from atomistic molecular dynamics simulations. The technique uses a neural network algorithm applied to a series of images encoding the distance between two molecules in time. We demonstrate that our algorithm is capable of separating with high accuracy mutations with low binding affinity from mutations with high binding affinity. Moreover, we show high accuracy in prediction using a small subset of the simulation, therefore requiring a much shorter simulation time. We apply our algorithm to the binding between several variants of the the SARS-CoV-2 spike protein and the human receptor ACE2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.07.434295v1" target="_blank">AI-driven prediction of SARS-CoV-2 variant binding trends from atomistic simulations</a>
</div></li>
<li><strong>Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses</strong> -
<div>
Although a variety of SARS-CoV-2 related coronaviruses have been identified, the evolutionary origins of this virus remain elusive. We describe a meta-transcriptomic study of 411 samples collected from 23 bat species in a small (~1100 hectare) region in Yunnan province, China, from May 2019 to November 2020. We identified coronavirus contigs in 40 of 100 sequencing libraries, including seven representing SARS-CoV-2-like contigs. From these data we obtained 24 full-length coronavirus genomes, including four novel SARS-CoV-2 related and three SARS-CoV related genomes. Of these viruses, RpYN06 exhibited 94.5% sequence identity to SARS-CoV-2 across the whole genome and was the closest relative of SARS-CoV-2 in the ORF1ab, ORF7a, ORF8, N, and ORF10 genes. The other three SARS-CoV-2 related coronaviruses were nearly identical in sequence and clustered closely with a virus previously identified in pangolins from Guangxi, China, although with a genetically distinct spike gene sequence. We also identified 17 alphacoronavirus genomes, including those closely related to swine acute diarrhea syndrome virus and porcine epidemic diarrhea virus. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species in Southeast Asia and southern China, with the largest contiguous hotspots extending from South Lao and Vietnam to southern China. Our study highlights both the remarkable diversity of bat viruses at the local scale and that relatives of SARS-CoV-2 and SARS-CoV circulate in wildlife species in a broad geographic region of Southeast Asia and southern China. These data will help guide surveillance efforts to determine the origins of SARS-CoV-2 and other pathogenic coronaviruses.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.08.434390v1" target="_blank">Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses</a>
</div></li>
<li><strong>SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection</strong> -
<div>
SARS-CoV-2 spillback from humans into domestic and wild animals has been well-documented. We compared variants of cell culture-expanded SARS-CoV-2 inoculum and virus recovered from four species following experimental exposure. Five nonsynonymous changes in nsp12, S, N and M genes were near fixation in the inoculum, but reverted to wild-type sequences in RNA recovered from dogs, cats and hamsters within 1-3 days post-exposure. Fourteen emergent variants were detected in viruses recovered from animals, including substitutions at spike positions H69, N501, and D614, which also vary in human lineages of concern. The rapidity of in vitro and in vivo SARS-CoV-2 selection reveals residues with functional significance during host-switching, illustrating the potential for spillback reservoir hosts to accelerate evolution, and demonstrating plasticity of viral adaptation in animal models.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.05.434135v1" target="_blank">SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection</a>
</div></li>
<li><strong>Structural Analysis of Spike Protein Mutations in an Emergent SARS-CoV-2 Variant from the Philippines</strong> -
<div>
A SARS-CoV-2 emergent lineage with multiple signature mutations in the Spike protein region was recently reported with cases centered in Cebu Island, Philippines. Whole genome sequencing revealed that the 33 samples with the Ph-B.1.1.28 emergent variant merit further investigation as they all contain the E484K, N501Y, and P681H Spike mutations previously found in other variants of concern such as the South African B.1.351, the Brazil P.1 and the UK B.1.1.7 variants. This is the first known report of these mutations co-occurring in the same virus. The possible implications of the mutations found in the Spike protein were analyzed for their potential effects on structure, stability, and molecular surface character. The analysis suggests that these mutations could significantly impact the possible interactions of the Spike protein monomer with the ACE2 receptor and neutralizing antibodies and warrants further clinical investigation. Some of the mutations affecting the N and C terminal domains may have effects on Spike monomer and trimer stability. This report provides insights on relevant targets for the design of future diagnostics, therapeutics and vaccines against the evolving SARS-CoV-2 variants in the Philippines.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.06.434059v1" target="_blank">Structural Analysis of Spike Protein Mutations in an Emergent SARS-CoV-2 Variant from the Philippines</a>
</div></li>
<li><strong>Comparative studies of the seven human coronavirus envelope proteins using topology prediction and molecular modelling to understand their pathogenicity</strong> -
<div>
Human (h) coronaviruses (CoVs) 229E, NL63, OC43, and HKU1 are less virulent and cause mild, self-limiting respiratory tract infections, while SARS-CoV, MERS-CoV, and SARS-CoV-2, are more virulent and have caused severe outbreaks. The CoV envelope (E) protein, an important contributor to the pathogenesis of severe hCoVs infections, may provide insight into this disparate severity of the disease. Topology prediction programs and 3D modelling software was used to predict and visualize structural aspects of the hCoV E protein related to its functions. All seven hCoV E proteins largely adopted different topologies, with some distinction between the more virulent and less virulent ones. The 3D models refined this distinction, showing the PDZ-binding motif (PBM) of SARS-CoV, MERS-CoV, and SARS-CoV-2 to be more flexible than the PBM of hCoVs 229E, NL63, OC43, and HKU1. We speculate that the increased flexibility of the PBM may provide the more virulent hCoVs with a greater degree of freedom, which can allow them to bind to different host proteins and can contribute to a more severe form of the disease. This is the first paper to predict the topologies and model 3D structures of all seven hCoVs E proteins, providing novel insights for possible drug and/or vaccine development.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.08.434384v1" target="_blank">Comparative studies of the seven human coronavirus envelope proteins using topology prediction and molecular modelling to understand their pathogenicity</a>
</div></li>
<li><strong>Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2</strong> -
<div>
Emerging evidence suggests that host glycans influence infection by SARS-CoV-2. Here, we reveal that the receptor-binding domain (RBD) of the spike (S)-protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (SA), with preference for the oligosaccharide of monosialylated gangliosides. Gangliosides embedded within an artificial membrane also bind the RBD. The monomeric affinities (Kd = 100-200 M) of gangliosides for the RBD are similar to heparan sulfate, another negatively charged glycan ligand of the RBD proposed as a viral co-receptor. RBD binding and infection of SARS-CoV-2 pseudotyped lentivirus to ACE2-expressing cells is decreased upon depleting cell surface SA level using three approaches: sialyltransferase inhibition, genetic knock-out of SA biosynthesis, or neuraminidase treatment. These effects on RBD binding and pseudotyped viral entry are recapitulated with pharmacological or genetic disruption of glycolipid biosynthesis. Together, these results suggest that sialylated glycans, specifically glycolipids, facilitate viral entry of SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.08.434228v1" target="_blank">Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2</a>
</div></li>
<li><strong>Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs</strong> -
<div>
Human coronaviruses have become an increasing threat to global health; three highly pathogenic strains have emerged since the early 2000s, including most recently SARS-CoV-2, the cause of COVID-19. A better understanding of the molecular mechanisms of coronavirus pathogenesis is needed, including how these highly virulent strains differ from those that cause milder, common-cold like disease. While significant progress has been made in understanding how SARS-CoV-2 proteins interact with the host cell, non-structural protein 3 (nsp3) has largely been omitted from the analyses. Nsp3 is a viral protease with important roles in viral protein biogenesis, replication complex formation, and modulation of host ubiquitinylation and ISGylation. Herein, we use affinity purification-mass spectrometry to study the host-viral protein-protein interactome of nsp3 from five coronavirus strains: pathogenic strains SARS-CoV-2, SARS-CoV, and MERS-CoV; and endemic common-cold strains hCoV-229E and hCoV-OC43. We divide each nsp3 into three fragments and use tandem mass tag technology to directly compare the interactors across the five strains for each fragment. We find that few interactors are common across all variants for a particular fragment, but we identify shared patterns between select variants, such as ribosomal proteins enriched in the N-terminal fragment (nsp3.1) dataset for SARS-CoV-2 and SARS-CoV. We also identify unique biological processes enriched for individual homologs, for instance nuclear protein important for the middle fragment of hCoV-229E, as well as ribosome biogenesis of the MERS nsp3.2 homolog. Lastly, we further investigate the interaction of the SARS-CoV-2 nsp3 N-terminal fragment with ATF6, a regulator of the unfolded protein response. We show that SARS-CoV-2 nsp3.1 directly binds to ATF6 and can suppress the ATF6 stress response. Characterizing the host interactions of nsp3 widens our understanding of how coronaviruses co-opt cellular pathways and presents new avenues for host-targeted antiviral therapeutics.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.08.434440v1" target="_blank">Comparative host interactomes of the SARS-CoV-2 nonstructural protein 3 and human coronavirus homologs</a>
</div></li>
<li><strong>Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract</strong> -
<div>
The nasal-mucosa constitutes the primary entry site for respiratory viruses including SARS-CoV-2. While the imbalanced innate immune response of end-stage COVID-19 has been extensively studied, the earliest stages of SARS-CoV-2 infection at the mucosal entry site have remained unexplored. Here we employed SARS-CoV-2 and influenza virus infection in native multi-cell-type human nasal turbinate and lung tissues ex vivo, coupled with genome-wide transcriptional analysis, to investigate viral susceptibility and early patterns of local-mucosal innate immune response in the authentic milieu of the human respiratory tract. SARS-CoV-2 productively infected the nasal turbinate tissues, predominantly targeting respiratory epithelial cells, with rapid increase in tissue-associated viral sub-genomic mRNA, and secretion of infectious viral progeny. Importantly, SARS-CoV-2 infection triggered robust antiviral and inflammatory innate immune responses in the nasal mucosa. The upregulation of interferon stimulated genes, cytokines and chemokines, related to interferon signaling and immune-cell activation pathways, was broader than that triggered by influenza virus infection. Conversely, lung tissues exhibited a restricted innate immune response to SARS-CoV-2, with a conspicuous lack of type I and III interferon upregulation, contrasting with their vigorous innate immune response to influenza virus. Our findings reveal differential tissue-specific innate immune responses in the upper and lower respiratory tract, that are distinct to SARS-CoV-2. The studies shed light on the role of the nasal-mucosa in active viral transmission and immune defense, implying a window of opportunity for early interventions, whereas the restricted innate immune response in early-SARS-CoV-2-infected lung tissues could underlie the unique uncontrolled late-phase lung damage of advanced COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.03.08.434404v1" target="_blank">Human nasal and lung tissues infected ex vivo with SARS-CoV-2 provide insights into differential tissue-specific and virus-specific innate immune responses in the upper and lower respiratory tract</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate a Single Dose of STI-2020 (COVI-AMG™) in Hospitalized Adults With COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: COVI-AMG;   Drug: Placebo<br/><b>Sponsor</b>:   Sorrento Therapeutics, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety &amp; Efficacy of Low Dose Aspirin / Ivermectin Combination Therapy for Treatment of Covid-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: 3-dayIVM 200 mcg/kg/day/14-day 75mgASA/day + standard of care (intervention 1)<br/><b>Sponsors</b>:   Makerere University;   Ministry of Health, Uganda;   Mbarara University of Science and Technology;   Joint Clinical Research Center<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Study in the Treatment of Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Molixan;   Drug: Placebo<br/><b>Sponsor</b>:   Pharma VAM<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Safety and Efficacy of FB2001 in Healthy Subjects and Patients With COVID-19 Infection</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: FB2001;   Drug: FB2001 Placebo<br/><b>Sponsor</b>:   Frontier Biotechnologies Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Diagnostic Performance of the ID Now™ COVID-19 Screening Test Versus Simplexa™ COVID-19 Direct Assay</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: ID Now™ COVID-19 Screening Test<br/><b>Sponsor</b>:   Groupe Hospitalier Paris Saint Joseph<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Safety and Efficacy Study of Human Monoclonal Antibodies, BRII-196 and BRII-198 for the Treatment of Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: BRII-196 and BRII-198;   Drug: Placebo<br/><b>Sponsor</b>:   Brii Biosciences, Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dose-Ranging Study to Assess the Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Melatonin;   Drug: Placebo<br/><b>Sponsors</b>:   State University of New York at Buffalo;   National Center for Advancing Translational Science (NCATS)<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Efficacy and Safety of Brilacidin in Hospitalized Participants With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Brilacidin;   Drug: Placebo;   Drug: Standard of Care (SoC)<br/><b>Sponsor</b>:   Innovation Pharmaceuticals, Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DCI COVID-19 Surveillance Project</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: SARS-CoV-2 RT-PCR Assay for Detection of COVID-19 Infection<br/><b>Sponsors</b>:   Temple University;   Dialysis Clinic, Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety, Tolerability and Pharmacokinetics of Second Generation VIR-7831 Material in Non-hospitalized Participants With Mild to Moderate COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: VIR-7831 (Gen1);   Biological: VIR-7831 (Gen2)<br/><b>Sponsors</b>:   Vir Biotechnology, Inc.;   GlaxoSmithKline<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Honey and Nigella Sativa in COVID-19 Prophylaxis</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Honey;   Drug: Nigella sativa seed;   Other: Placebo<br/><b>Sponsor</b>:   Sohaib Ashraf<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Thymic Peptides in the Treatment of Hospitalized COVID-19 Patients in Honduras</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Thymic peptides<br/><b>Sponsors</b>:   Universidad Católica de Honduras;   Pontificia Universidad Catolica de Chile<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety, Tolerability, and Immunogenicity of the COVID-19 Vaccine Candidate (VBI-2902a)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: VBI-2902a;   Biological: Placebo<br/><b>Sponsor</b>:   VBI Vaccines Inc.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Breathing Exercise After COVID-19 Pneumonia</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Breathing exercise with the phone application;   Other: Breathing exercise<br/><b>Sponsor</b>:   Tokat Gaziosmanpasa University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Comparison of Remdesivir and Tocilizumab Versus Hydroxychloroquine and Tocilizumab Combination in COVID-19 Patients</strong> - <b>Conditions</b>:   Covid19;   Pneumonia<br/><b>Interventions</b>:   Drug: Remdesivir;   Drug: Hydroxychloroquine;   Drug: Tocilizumab<br/><b>Sponsors</b>:   October 6 University;   Beni-Suef University<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication</strong> - The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the coronavirus behind the ongoing COVID-19 pandemic. A recent, large-scale, retrospective clinical study showed that famotidine, when administered at a high dose to hospitalized COVID-19 patients, reduced the rates of intubation and mortality. A separate, patient-reported study associated famotidine use with improvements in…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2</strong> - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome contains nine open reading frames (ORFs) that encode for accessory proteins which, although dispensable for viral replication, are important for the modulation of the host infected cell metabolism and innate immunity evasion. Among those, the ORF8 gene encodes for the homonymous multifunctional, highly immunogenic, immunoglobulin-like protein that was recently found to inhibit presentation of viral antigens by class I major…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An in-silico approach to identify the potential hot spots in SARS-CoV-2 spike RBD to block the interaction with ACE2 receptor</strong> - A novel acute viral pneumonia induced by SARS-CoV-2 exploded at the end of 2019, causing a severe medical and economic crisis. For developing specific pharmacotherapy against SARS-CoV-2, an in silico virtual screening was developed for the available in-house molecules. The conserved domain analysis was performed to identify the highly conserved and exposed amino acid regions in the SARS-CoV-2-S RBD sites. The Protein-Protein interaction analyses demonstrated the higher affinity between the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intestinal SGLT1 as a therapeutic target in COVID-19-related diabetes: A “two-edged sword” hypothesis</strong> - Emerging data are linking coronavirus disease 2019 (COVID-19) with an increased risk of developing new-onset diabetes. The gut has been so far out of the frame of the discussion on the pathophysiology of COVID-19-induced diabetes, with the pancreas, liver, and adipose tissue being under the spotlight of medical research. Sodium-glucose co-transporters (SGLT) 1 represent important regulators of glucose absorption, expressed in the small intestine where they mediate almost all sodium-dependent…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ensemble-based screening of natural products and FDA-approved drugs identified potent inhibitors of SARS-CoV-2 that work with two distinct mechanisms</strong> - The recent outbreak of SARS-CoV-2 is responsible for high morbidity and mortality rate across the globe. This requires an urgent identification of drugs and other interventions to overcome this pandemic. Computational drug repurposing represents an alternative approach to provide a more effective approach in search for COVID-19 drugs. Selected natural product known to have antiviral activities were screened, and based on their hits; a similarity search with FDA approved drugs was performed using…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A SARS-CoV-2 spike binding DNA aptamer that inhibits pseudovirus infection by an RBD independent mechanism</strong> - The receptor binding domain (RBD) of the spike glycoprotein of the coronavirus SARS-CoV-2 (CoV2-S) binds to the human angiotensin converting enzyme 2 (ACE2) representing the initial contact point for leveraging the infection cascade. We used an automated selection process and identified an aptamer that specifically interacts with CoV2-S. The aptamer does not bind to the RBD of CoV2-S and does not block the interaction of CoV2-S with ACE2. Notwithstanding, infection studies revealed potent and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tandem high-dose influenza vaccination is associated with more durable serologic immunity in patients with plasma cell dyscrasias</strong> - Patients with plasma cell dyscrasias (PCDs) experience an increased burden of influenza, and current practice of single-dose annual influenza vaccination yields suboptimal protective immunity in these patients. Strategies to improve immunity to influenza in these patients are clearly needed. We performed a randomized, double-blind, placebo-controlled clinical trial comparing tandem Fluzone High-Dose influenza vaccination with standard-of-care influenza vaccination. Standard-of-care vaccination…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Oral Angiotensin Converting Enzyme Inhibitors for the Treatment of Delayed Inflammatory Reaction of Dermal Hyaluronic Acid Fillers Following COVID-19 Vaccination - A Model for Inhibition of Angiotensin II-Induced Cutaneous Inflammation</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features</strong> - CONCLUSION: Our comprehensive analyses provide important insights into SARS-CoV-2 humoral immunity across distinct serology assays and their applicability for specific research and/or diagnostic questions to assess SARS-CoV-2-specific humoral responses.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19</strong> - CONCLUSION: Despite possible indication bias, until further evidence emerges we recommend adhering to public health measures, a low threshold to seek medical advice and close monitoring of symptoms in those who take immunosuppressants routinely regardless of their indication. However, it should be noted that the inability to control for the underlying condition requiring immunosuppressants is a major limitation, and hence caution should be exercised in interpretation of the results.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Hydroalcoholic Extract of Uncaria tomentosa (Cat’s Claw) Inhibits the Infection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) In Vitro</strong> - The coronavirus disease 2019 (COVID-19) has become a serious problem for public health since it was identified in the province of Wuhan (China) and spread around the world producing high mortality rates and economic losses. Nowadays, the WHO recognizes traditional, complementary, and alternative medicine for treating COVID-19 symptoms. Therefore, we investigated the antiviral potential of the hydroalcoholic extract of Uncaria tomentosa stem bark from Peru against SARS-CoV-2 in vitro. The…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibitory efficacy of RNA virus drugs against SARS-CoV-2 proteins: An extensive study</strong> - Herein we have made a comprehensive analysis of inhibitory efficacy of 16 RNA virus drugs against RdRp, Mpro and PLpro proteins of SARS-CoV-2. Analysis of docked conformation revealed that Baloxavir marboxil (BMX) corresponds to the highest binding energy. Analysis of residue confirmed that BMX strongly interact with these three proteins involving H-bonding, ionic as well as hydrophobic interactions. Molecular dynamics simulation and analysis of parameters like RMSD, RMSF, binding energy…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Screening potential FDA-approved inhibitors of the SARS-CoV-2 major protease 3CL(pro) through high-throughput virtual screening and molecular dynamics simulation</strong> - It has been confirmed that the new coronavirus SARS-CoV-2 caused the global pandemic of coronavirus disease 2019 (COVID-19). Studies have found that 3-chymotrypsin-like protease (3CL^(pro)) is an essential enzyme for virus replication, and could be used as a potential target to inhibit SARS-CoV-2. In this work, 3CL^(pro) was used as the target to complete the high-throughput virtual screening of the FDA-approved drugs, and Indinavir and other 10 drugs with high docking scores for 3CL^(pro) were…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Docking-based virtual screening studies aiming at the covalent inhibition of SARS-CoV-2 M(Pro) by targeting the cysteine 145</strong> - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 which has infected millions of people worldwide. The main protease of SARS-CoV-2 (M^(Pro)) has been recognized as a key target for the development of antiviral compounds. Taking advantage of the X-ray crystal complex with reversible covalent inhibitors interacting with the catalytic cysteine 145 (Cys145), we explored flexible docking studies to select alternative compounds able to target this residue…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity</strong> - BACKGROUND: Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However, antiviral activity of Camostat mesylate metabolites and potential viral resistance have not been analyzed. Moreover, antiviral activity of Camostat mesylate in human lung tissue remains to be demonstrated.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sars-CoV-2 vaccine antigens</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318283136">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-COV-2 BINDING PROTEINS</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318004130">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compositions and methods for detecting SARS-CoV-2 spike protein</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU317343760">link</a></p></li>
<li><strong>Aronia-Mundspray</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Anordnung zum Versprühen einer Substanz in die menschliche Mundhöhle und/oder in den Rachen, dadurch gekennzeichnet, dass die Anordnung eine Sprühflasche mit einer Substanz aufweist, die wenigstens Aroniasaft und eine Alkoholkomponente aufweist.
</p>
<ul>
<li><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE319581893">link</a></li>
</ul></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种3-羟基丁酰化修饰蛋白质药物及其制备方法和应用</strong> - 本发明涉及医药技术领域，公开了一种3‑羟基丁酰化修饰蛋白质药物（例如抗体）及其制备方法和应用，特别是一种3‑羟基丁酰化修饰抗体及其制备方法和应用。发明人经过大量实验发现，3‑羟基丁酸及其类似物修饰蛋白质药物（例如抗体）后，可以显著提高蛋白质药物的热稳定性、对蛋白酶水解的抗性，降低蛋白质药物的等电点，并显著延长其在受试者体内的半衰期，进而提高其药效。修饰后所得蛋白质药物在科研和临床方面具有广阔的应用前景和较高的商业价值。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318140486">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>新冠病毒重组融合蛋白、其制备方法和应用</strong> - 本发明提供一种新冠病毒重组融合蛋白、其制备方法和应用。本发明通过对新冠病毒S和N重组融合蛋白的基因序列进行设计，选择最优的片段进行整合，再通过人源HEK293细胞系统重组表达融合蛋白，经过纯化后对融合蛋白的分子量、纯度进行检测，最后利用融合蛋白制成新冠病毒抗体胶体金检测试纸条/试剂盒。与单独使用S蛋白或N蛋白制备的胶体金检测试纸条相比，该重组融合蛋白制备的胶体金检测试纸条具有更高的灵敏度和更低的漏检率。此外，本发明提供的新冠病毒重组融合蛋白可广泛应用于不同平台技术的新冠抗体检测试剂盒开发，如胶体金、荧光免疫层析、化学发光和酶联免疫等。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318140491">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Atemluft-Desinfektionsvorrichtung und Atemschutzmaske</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Atemluft-Desinfektionsvorrichtung mit einem am Körper eines Lebewesens (2) tragbaren Gehäuse (32), aufweisend:</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">eine im Gehäuse (32) ausgebildete frei durchströmbare Atemluft-Bestrahlungskammer (33), die frei von den Strömungswiderstand erhöhenden Einbauten oder Umlenkabschnitten ist, und die an einem Ende (34.1) der Atemluft-Bestrahlungskammer (33) eine im Strömungsweg der Nase und/oder dem Mund des Lebewesens (2) zugewandte erste Durchtrittsöffnung (35.1) aufweist und an einem anderen Ende (34.2) der Atemluft-Bestrahlungskammer (33) eine im Strömungsweg von der Nase und/oder von dem Mund des Lebewesens (2) abgewandte zweite Durchtrittsöffnung (35.2) aufweist, wobei die Atemluft-Bestrahlungskammer (33) von wenigstens einer UV-reflektierenden Kammer-Innenwand (36) begrenzt ist, die aus einem wärmeleitenden Material besteht,</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">wenigstens eine im Gehäuse (32) angeordnete, in die Atemluft-Bestrahlungskammer (33) einstrahlende UV-LED-Einheit (31, 31.1, 31.2), die ausgebildet und eingerichtet ist, den Innenraum der Atemluft-Bestrahlungskammer (33) mit UV-Strahlen vollständig zu beaufschlagen, und</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">wenigstens einen sich außerhalb der Atemluft-Bestrahlungskammer (33) erstreckenden Kühlkörper (37), der thermisch sowohl an die wenigstens eine UV-LED-Einheit (31, 31.1, 31.2), als auch an die aus dem wärmeleitenden Material bestehende Kammer-Innenwand (36, 39, 40) angekoppelt ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE319581907">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>稳定的冠状病毒重组蛋白二聚体及其表达载体</strong> - 本发明公开了稳定的冠状病毒重组蛋白二聚体及其表达载体，冠状病毒重组蛋白，由冠状病毒S蛋白S‑RBD、冠状病毒N蛋白的CTD区N‑CTD和将二者偶联的连接子构成。本发明一些实例的冠状病毒重组蛋白，可以形成并维持稳定的二聚体结构，避免单体S‑RBD降解，有利于提高冠状病毒重组蛋白的免疫原性，有望用于制备检测试剂原料、疫苗、抗体、预防或治疗性药物。本发明一些实例的冠状病毒重组蛋白二聚体，具有很好的免疫原性。在疫苗开发领域具有广阔的应用前景。本发明一些实例的表达载体，易于表达冠状病毒重组蛋白二聚体且表达量高。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318107321">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SELF-CLEANING AND GERM-KILLING REVOLVING PUBLIC TOILET FOR COVID 19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU318003558">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种新冠病毒S1蛋白的灌流生产系统及方法</strong> - 本发明涉及细胞生物学技术领域，提供了一种新冠病毒S1蛋白的灌流生产系统及方法，包括：细胞反应器，用于培养表达S1蛋白的细胞株；灌流系统，包括过滤装置、出液管、回液管和第一循环泵，所述过滤装置的主体内设有孔径为0.1‑0.2μm的中空纤维柱，用于过滤透出液，截留细胞培养液中的S1蛋白；所述出液管的两端分别与所述细胞反应器和所述中空纤维柱的下端相连通；所述回液管的两端分别与所述细胞反应器和所述中空纤维柱的上端相连通；所述第一循环泵设置于所述出液管与所述中空纤维柱相连的管路中。本发明系统投入成本低且S1蛋白产量高。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN318107249">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What the Coronavirus Variants Mean for the End of the Pandemic</strong> - The virus is mutating—but we can still beat it, one vaccination at a time. - <a href="https://www.newyorker.com/science/medical-dispatch/what-the-coronavirus-variants-mean-for-the-end-of-the-pandemic">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Vicar of Christ Calls on the Grand Ayatollah</strong> - In a historic meeting in Iraq, the leaders of Catholicism and Shiite Islam urged coexistence among the Abrahamic faiths. - <a href="https://www.newyorker.com/news/our-columnists/the-vicar-of-christ-calls-on-the-grand-ayatollah">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Civilian Climate Corps Is a Big-Government Plan That All Americans Can Embrace</strong> - Biden’s proposal draws on a New Deal program that created jobs and helped unite the country. - <a href="https://www.newyorker.com/news/daily-comment/the-civilian-climate-corps-is-a-big-government-plan-that-all-americans-can-embrace">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Life After Vaccination</strong> - Dr. Ashish K. Jha considers what restrictions should remain in place once a large number of Americans have received protection against COVID-19. - <a href="https://www.newyorker.com/news/q-and-a/life-after-covid-19-vaccination">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What Meghan and Harry’s Oprah Interview Clarifies for Americans—and Maybe the British, Too</strong> - Why did we ever find all of this so amusing? - <a href="https://www.newyorker.com/news/daily-comment/what-meghan-and-harrys-oprah-interview-clarifies-for-americans-and-maybe-the-british-too">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>How Meghan Markle’s openness about her suicidal thoughts could help others</strong> -
<figure>
<img alt="Prince Harry and Meghan Markle speak to Oprah in a CBS interview" src="https://cdn.vox-cdn.com/thumbor/U2j_8Unz_MUPDO7i-eybNBhghe8=/0x0:7200x5400/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68932812/1231537336.0.jpg"/>
<figcaption>
Prince Harry and Meghan Markle speak to Oprah in a CBS interview. | Harpo Productions/Joe Pugliese via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In telling Oprah about her struggles with mental health, Meghan shed light on the stigma of asking for help.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cY3Z81">
One of the most emotional moments in Prince Harry and Meghan Markle’s Sunday tell-all interview with Oprah is when Meghan opened up about the suicidal thoughts she experienced during her <a href="https://www.vox.com/culture/22318918/meghan-markle-oprah-race-archie-harry-british-royal-family">pregnancy with Archie</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kg5hdP">
“Look, I was really ashamed to say it at the time and ashamed to have to admit it to Harry, especially, because I know how much loss he has suffered, but I knew that if I didn’t say it, then I would do it,” Meghan told Oprah. “I just didn’t want to be alive anymore.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EEBKqW">
Meghan explained that the relentless, negative media coverage of her — and the palace’s unwillingness to refute false stories — caused her distress. She also said her request for mental health care was denied by the royal family; when she then went to the palace’s human resources department, she said she was told they could not help her, as she was not a paid employee.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Em8xAz">
Meghan’s account paints a bleak picture of royal life, and further elucidates the effects of the UK’s harmful and <a href="https://www.vox.com/culture/22318918/meghan-markle-oprah-race-archie-harry-british-royal-family">racist tabloid press</a>. But her story is also one of resilience, and helps to eliminate the stigma around and bring broader awareness to mental health issues.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dfocze">
To understand more about the impact of Meghan’s story, I spoke with <a href="https://faculty.utulsa.edu/faculty/elana-newman/">Elana Newman</a>, a professor of psychology at the University of Tulsa, as well as the research director at the Dart Center for Journalism and Trauma, a project from Columbia University that trains journalists on how to report about trauma, mental illness, and conflict.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="exgZtL">
This interview has been edited and condensed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5ppJrj">
<strong>What were your initial thoughts about the interview, and Meghan Markle’s admission that she’s had suicidal thoughts and actively sought therapy?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t9jWeV">
I see it as powerful and courageous. It’s incredible in terms of addressing the stigma of suicidal thoughts, because publicly talking about this is very important. The interview can raise that dialogue.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Le8C65">
Some people have such shame and keep it secret. The fact that Meghan said she sought help and then that was thwarted, that also addresses the issue of how we need to improve services and access to mental health resources for people who are suicidal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gtbESb">
I don’t know this for a matter of fact, but I’d be curious on the usage of suicide hotlines today, in response.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xJRFyF">
<strong>Do we often see a demonstrable impact when a celebrity talks about living with trauma?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bIutKi">
I do think Megan Markle talking about suicide has incredible cultural impact. The same was true with Princess Diana and her struggles with eating disorders; that broke through a lot of stigma as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qwR3fm">
There’s a lot of distrust, stereotyping, shunning, and avoidance of those affected by suicide, including family members who’ve had loved ones die by suicide. It’s something that people are uncomfortable with, and so they don’t want to talk about it. That cultural milieu prevents people who need help from seeking it, and Meghan’s interview can be very helpful in empowering people to do so.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8z78Q4">
<strong>Meghan has talked about being mistreated by the media, and the Oprah interview means there will be even more coverage of her, and about very serious and sensitive topics. The Dart Center trains journalists to talk to people experiencing trauma and to write those stories accurately and sensitively. Have you seen this kind of coverage improve?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gv6J2C">
There are certainly more conversations about how the press frames trauma now. People are changing their thoughts about, for example, how you interview rape survivors, and people are thinking about the ethical issues and informed consent. In terms of suicide reporting, in particular, it means providing resources and not focusing on the details.
</p>
<div class="c-float-right">
<div id="uGNS4G">
<div>
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9SkRAb">
In the 20 years that I’ve been doing this work, I think that there is more dialogue. People are doing more innovative reporting, even in the ways that they approach these stories.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OAMR2y">
For example, saying, “How do we look at this?” instead of going over the gory details about suicide. “How is this dialogue going to improve the conversation?” and “What are the next steps?” are questions we should be asking.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gbETcd">
<strong>So what are the next steps?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2ks6P1">
The next steps here are continuing to educate people about the myths about suicide. There’s a conversation about increasing accessibility, too. I mean, if a princess asked for help, and couldn’t get help, what does this say about accessing mental health care? For me, that’s a real question.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Sn7zMp">
What does this say about our own system in the US? If you’re feeling sick and it’s hard to get help, can you imagine what happens when it’s a stigmatized illness? Imagine the energy it takes to ask for help, and then to have that denied.
</p>
<div>
<aside id="jRHYBG">
<q>“If a princess asked for help, and couldn’t get help, what does this say about accessing mental health care?”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7R8Gdy">
<strong>What you’re getting at, I think, is how the conversation we should be having is about inequity. Meghan Markle is a princess and has a lot of resources, and she still struggled to get help. People in poverty or without health insurance do not have those resources, and the story is radically different for them.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S2YAnj">
That’s the story there. What do we need to do to change that? What are the next steps? Because this indicates, if a princess can’t get services, what about the rest of us? And what will it take as a society to enhance access to mental health care?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="00cncN">
<strong>In the interview, Harry and Meghan talk positively about therapy. That seems really big, too.</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vPK7HU">
We don’t have these questions and stigma about treatments for blood pressure, for diabetes, or for [other] ailments. Mental health issues are and should be the same. I think the other, more radical issue for me is the whole issue of having health care and mental health care be associated with your employment.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KCtB92">
It raised that question to me as a citizen. Here’s somebody who goes to their workplace, which isn’t [formally or technically] their workplace, but she was doing work for them. And they’re saying, since you’re unemployed, you don’t get benefits.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sEWwYx">
We need to look at how we help <em>all</em> the citizens of our nation get mental health care and get effective treatments.
</p>
<aside id="9BeLUs">
<div>
</div>
</aside></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>What is “the institution”? What is “the firm”? A royals expert explains.</strong> -
<figure>
<img alt="Tabloid covers of Meghan Markle and the Queen lie scattered." src="https://cdn.vox-cdn.com/thumbor/1T0gTSJWk-d6_tgKnL8aI9g393A=/226x0:3774x2661/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68932738/GettyImages_1231591898.0.jpg"/>
<figcaption>
What does the royal drama mean for the future of the family? | Glyn Kirk/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Here are the answers to your most burning questions about Meghan and Harry’s Oprah interview.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vQKCAD">
Meghan Markle and Prince Harry’s revealing interview with Oprah Winfrey has shocked the world, but for those of us who don’t have an intimate knowledge of the royal family, there might be as many questions as answers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HUYQ0U">
While it seems clear that Meghan and Harry faced racism from the British press and suffered from a lack of support from within Windsor Castle, it can be hard to sort out rules and rankings, especially as an American. What is<em> </em>“the royal institution?” Has Harry lost his title, and was Archie denied a royal title due to all the drama? And in their exodus, how will Meghan and Harry make money? It’s enough to make anyone’s head spin.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PoqIsb">
Victoria Arbiter, a royals commentator based in New York, spoke with Vox to clear up all the confusion and to discuss the repercussions of the bombshell interview.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zeWgHU">
<strong>There’s a lot of confusion around terms like “the institution” and “the firm” and “the royal family.” Can you clear up the difference between those three titles? What is “the institution”?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZWyRTw">
It’s a very complex and complicated answer. “The institution” refers to the institution of monarchy — the business of monarchy — so its public role. Within the institution of monarchy, there are palace aides. There will be private secretaries that oversee the diary and the day-to-day handlings of senior members of the royal family. There is a communications team that handles the press. Within the royal household, there are people that oversee the day-to-day running of the monarchy, whether it’s those that are working in the kitchens or those responsible for winding up the Queen’s clocks — that is a job. The institution of monarchy is the big picture.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Sfn543">
<strong>And what is “the firm”? </strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EhO9Gi">
Now as for the firm, this is quite interesting. George VI, the Queen’s father, was the first person to have coined that phrase. What he was referring to was the family business. So historically, “the firm” has referred to senior working members of the royal family.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ak8Apz">
In the interview, Meghan jumps between saying “the institution” and “the firm.” I don’t think she is saying “the firm” in context to referencing senior members of the family. I think she’s using it in the same vein as she’s using the phrase “the institution.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="znvSBT">
<strong>And then there’s the family? </strong>
</p>
<div class="c-float-right">
<aside id="jmLpMQ">
<q>“The Queen is the head of the institution. She is the monarch and she runs the show.”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OtIfrJ">
This is where the lines become quite blurred because the queen is the head of the institution. She is the monarch and she runs the show. But at the same time, she’s Harry’s grandmother. So it’s difficult in that respect because the buck rests with her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sJELd3">
While Harry and Meghan were very effusive in their praise of the queen, and they reiterated multiple times how wonderful she has been, still, she’s the head of the institution of the monarchy. So in criticizing the institution, they’re essentially laying blame on the queen as well. They’re not doing it directly. And I think they would be saddened if they realized that’s how it comes across because I genuinely believe their great affection for the queen. But it’s like, if you were to criticize Apple, the blame for whatever that criticism is really does rest with the CEO. It’s similar in that respect.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XQhbbz">
<strong>So the firm is more of the upper-level royals, such as the queen, who uphold monarchy?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="njtudi">
I don’t think Meghan was using the words “the firm” in reference to the family in this instance. It appeared that she was alternating between saying “institution” and “firm” but meaning the same thing.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IYIY22">
The senior working members are within the institution of monarchy. But [the institution] also references all the aides that see to the day-to-day running. There were several times that Harry and Meghan said they went to the institution to complain about XYZ issues. There was one point where they did say “senior palace aide.” So the institution can represent the senior members of the working royal family, but can also represent senior members of staff that oversee the day-to-day running of the royal family and indeed the monarchy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6kTrz5">
But historically, “the firm” has referenced senior working members of the royal family.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wgFrVy">
<strong>Meghan and Harry referenced a kind of HR system in place. What is the royal HR system like, and how similar is it to the typical HR departments that Americans in particular might imagine?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OqKWed">
The HR department is human resources, just like at any other company. Because while Buckingham Palace is a palace, it is also the seat of the British monarchy and it is a working office. There is a human resources department because they have a responsibility to protect the staff and to make sure that everything is being done in an ethically moral fashion, just like any business.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vgxtr2">
So if an employee complains, the HR department is responsible for investigating that claim. Meghan said in the interview that she went to HR to say that she needed help, and she wasn’t getting it. Human resources, whichever member of staff it was, said, “We can’t help you because you are not a paid employee.” Which she wasn’t. She was a member of the family. But I think Meghan was sort of looking for help wherever she could find it. That was one area where the door was closed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s31zE1">
But the human resources department would operate just the same as any other business. It is there to protect the welfare and well-being of employees, to make sure there is no harassment and that everything is operating in a safe, acceptable, and professional fashion.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w6bVnz">
<strong>It’s interesting because it functions as a business, but it’s also an actual family. How does money work for the royals, and specifically how do Harry and Meghan make money? Do royals get salaries or any other equivalent?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MomVr0">
This is especially complicated. How Meghan and Harry choose to make money moving forward is entirely their business. We know that they have a very lucrative deal with Netflix and Spotify. We know that Meghan has invested in a vegan coffee brand. We know that they are represented by an agency that oversees public speakers, so there’s a number of ways, but how they choose to do that is their business. They are private citizens and just like anybody else, and they now have to earn a living.
</p>
<div class="c-float-right">
<aside id="mJLuL8">
<q>“Under those rules, at this juncture, Archie would never have been born a Prince or an HRH”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7fyz9E">
<strong>What about other members of the royal family? Does taxpayer money go toward them?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="METLRx">
When it comes to the royal family, there is the Sovereign Grant, which is a percentage of money that’s given to the monarchy each year, and that oversees the business of the monarchy. It pays for anything related to business expenses that are incurred by the running of the British monarchy in its role as public officials. A lot of them have individual investments. We don’t know about that. That is not our business. That is money that they had through inheritances and through investments, but it is not public knowledge nor public business. But the Sovereign Grant is given to them by the government, and it is essentially taxpayer money.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h5aC9h">
The royals are not paid. They do not receive a salary. They are given the funds to run their offices and to oversee their business expenses, but they don’t get a paycheck each week. There are certain things, like any clothes, for example, that Kate buys privately, to wear in her private time, she pays for those herself. But there will be a certain amount of money that is assigned to her from Prince Charles to cover her professional wardrobe. She has to wear hats and certain outfits that are expected and are deemed appropriate for the job that she’s doing. There are business-related expenses, as there are in many professions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IixXFs">
<strong>So Meghan and Harry were cut off from royal security. I’m wondering how royal security works and if this is tied to that budget. Is that something royals are typically provided with?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gTPHwr">
Scotland Yard decides which royals are given taxpayer-funded security. That is determined based on the threat risk. Senior working royals are going to have a far greater threat risk than someone else. Charles, Camilla, the queen, William, Kate, and Harry and Meghan before they left, all had taxpayer-funded security.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9xkFC2">
Their security was removed, but what was not addressed [in the interview] was the fact that British taxpayers fund the police officers that are assigned to look after those royals. They were living in Canada as private individuals. They then moved to the United States. They couldn’t justify to the British taxpayers why they were still having taxpayer-funded security, even though they were living in another country and they were no longer senior working members of the royal family.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rYm1eL">
Now, Harry was right that the threat assessment risk hadn’t dropped. He was just as much a target as he was before, but the royal family answers to the British public, and the British public needs to know that they’re getting value for their money. If they found out that their taxpayer funds were going to protect two private individuals living 6,000 miles away, there would have been an outcry. So that’s why Harry and Meghan lost their taxpayer-funded security.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZI9u3W">
<strong>As for her son, Archie, and his royal title, why was he denied a royal title? How are titles granted throughout the royal family?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QDaS7Z">
In 1917, George V, who is Harry’s great-great grandfather, issued letters patent. The letters patent dictated who would have titles moving forward. It was really in an effort to streamline the monarchy so that there weren’t dozens and dozens of HRHs and princes and princesses. According to that letters patent, the children of the sovereign, the grandchildren of the sovereign in the male line, and the eldest son of the Prince of Wales would have the HRH and a title, meaning prince or princess. That was it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sbUR6o">
In 2012, the Queen amended the letters patent to include all children of the eldest son of the Prince of Wales. The reason she did that is because she had just overseen the changes in the laws to succession. Meaning, that if a daughter was born first, as the first child, she would retain her place in line, as opposed to being set aside in favor of the younger-born brother. So if the Queen did not change the rules, it would mean that if Charlotte was born first, she would be Lady Charlotte. The queen was just tying up loose ends. She was just making sure that she crossed the t’s and dotted the i’s. As it turns out, the boy was born first so it didn’t matter.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xYQbRN">
Under those rules, at this juncture, Archie would never have been born a prince or an HRH. That goes back to 1917. It has absolutely nothing to do with being born to interracial parents.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ojuhXu">
Under these same rules, once Prince Charles becomes king, his status automatically jumps up. So Archie will be a prince when Charles becomes king, based on the rules laid out in 1917. Now, as the son of a Duke, Archie does have a courtesy title. He is entitled to be known as the Earl of Dumbarton, one of Harry’s titles. He could be known by that, but Harry and Meghan chose not to do that, and for him to just be Master Archie Harrison Mountbatten-Windsor.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3jB3sN">
<strong>But Harry is still considered a prince?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3WwwC4">
Harry is, yes, because Harry is the grandchild of the sovereign. But under the 1917 letters patent, he’s the second son of the Prince of Wales. It’s only the eldest son of the Prince of Wales whose children have titles.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="280dVX">
<strong>Some people are wondering if the queen and Prince Philip are related. Is this just a rumor, or are they biologically related?</strong>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l6Ezkk">
They’re husband and wife. They’re both descendants of Queen Victoria, but not in any weird, icky, funky fashion. They’re removed enough.
</p>
<aside id="BPv3nF">
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</aside>
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<li><strong>Georgia Republicans vote to roll back no-excuse absentee voting after Trump’s loss</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/hzJGdRsS0MFA2BlnC_eceDrG81Y=/205x0:3761x2667/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68931435/GettyImages_1230428919.0.jpg"/>
<figcaption>
Donald Trump speaks during a campaign rally in Dalton, Georgia, on January 4, 2021, where he revisited his claims that voter fraud robbed him of reelection. | Elijah Nouvelage/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Georgia Republicans passed no-excuse absentee voting in 2005. Now they want to end it.
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Georgia lawmakers <a href="https://www.brennancenter.org/our-work/research-reports/state-voting-bills-tracker-2021">have introduced more than 20 bills seeking to curtail voting rights</a> this year, including legislation the Senate passed 29-20 today that would repeal no-excuse absentee voting for the vast majority of the state’s voters.
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The <a href="https://www.legis.ga.gov/legislation/60009">new bill</a> would require voters to be absent from their precinct, have a physical disability or care for someone with one, observe a religious holiday, be unable to go to the polls because of their job, be at least 65 years old, or be covered by military absentee voting protections in order to get an absentee ballot. It also establishes ID requirements for requesting an absentee ballot, further complicating the requirements to receive one.
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NEW: Republicans in the Georgia Senate narrowly approved SB 241, an omnibus voting bill that would end no-excuse absentee voting 16 years after Republicans first enacted it. <a href="https://twitter.com/hashtag/gapol?src=hash&amp;ref_src=twsrc%5Etfw">#gapol</a><br/><br/>29-20 vote includes 4 Republicans that didn’t vote.<a href="https://t.co/BH9OAYjxnS">https://t.co/BH9OAYjxnS</a>
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— stephen fowler (<span class="citation" data-cites="stphnfwlr">@stphnfwlr</span>) <a href="https://twitter.com/stphnfwlr/status/1369042267542085636?ref_src=twsrc%5Etfw">March 8, 2021</a>
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As Georgia Public Broadcasting (GPB) <a href="https://www.gpb.org/news/2021/03/07/16-years-later-georgia-lawmakers-flip-views-on-absentee-voting">reports</a>, “some of the most controversial measures now on the table would overturn provisions that Republicans introduced more than 15 years ago — over Democratic objections — and that have guided state elections ever since.” The state’s no-excuse absentee voting that Republicans now want to repeal, for example, was part of the 2005 legislative package which originally allowed vote by mail without excuse or ID.
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No-excuse absentee voting can expand access to the ballot for people who may have trouble finding time to vote in person because of their job, their dependents, or health issues. While detractors point to the potential for fraud or coercion with this type of voting, there is little evidence that these claims are true. According to <a href="https://www.nytimes.com/article/mail-in-vote-fraud-ballot.html">the New York Times</a>, “in states that have long embraced mail-in voting … those running elections see no evidence of widespread fraud.” In Georgia, an audit by Republican Secretary of State Brad Raffensperger’s office of one major Georgia county found <a href="https://www.ajc.com/politics/no-fraud-georgia-audit-confirms-authenticity-of-absentee-ballots/QF2PTOGHLNDLNDJEWBU56WEQHM/">zero cases of fraud</a> among the roughly 15,000 absentee ballots reviewed.
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But the debate has become unmoored entirely from the potential costs and benefits of the system to voters and election integrity and largely hinges on a political question: Do you accept that former President Donald Trump fairly lost the 2020 presidential election?
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GPB notes that Republican Gov. Brian Kemp and Republican Party chairman David Shafer were originally in favor of no-excuse absentee voting, but now Shafer has rescinded his support. Kemp strongly endorses adding photo ID requirements and is “reserving judgment” on a litany of other measures that would raise the bar for ballot access, according to the <a href="https://www.ajc.com/politics/kemp-photo-id-requirements-for-absentee-ballots-front-and-center-this-year/6LXZHEUZKJEVVILOVZORQDYAOI/">Atlanta Journal-Constitution</a>.
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Republicans appear to have made this about-face following Trump’s loss and subsequent attempts to overturn the election results; now they’re seizing on it to enact restrictive voting legislation.<strong> </strong>Morning Consult’s <a href="https://morningconsult.com/form/tracking-voter-trust-in-elections/">polling</a> shows that only 32 percent of registered Republicans believe the 2020 presidential election was “probably” or “definitely” free and fair. Importantly, a lot of this might be reflecting whether or not respondents are happy with the result of the election. On November 1, only 52 percent of registered Democrats said they believed the election was free and fair — 8 days later, following Biden’s victory, that number jumped nearly 40 points.
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<img alt=" " src="https://cdn.vox-cdn.com/thumbor/9UYGc5F0ZIMNLQTn9dDlN8WZTbs=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22354452/Screen_Shot_2021_03_08_at_2.13.03_PM.png"/>
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<a class="ql-link" href="https://morningconsult.com/form/tracking-voter-trust-in-elections/" target="_blank">Morning Consult Jan. 22-25 survey of 1,990 registered voters nationwide. </a>
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Georgia isn’t alone in seeking to make changes to its electoral system — <a href="https://www.brennancenter.org/our-work/research-reports/state-voting-bills-tracker-2021">according to the Brennan Center</a>, “253 bills with provisions that restrict voting access” have been proposed in 43 states. On the flip side, House Democrats have passed House Resolution 1, a massive democracy reform bill that, among other things, expands voting rights. One of its key voting provisions, as Vox’s Ella Nilsen <a href="https://www.vox.com/2021/3/3/22309123/house-democrats-pass-voting-rights-bill-hr1">reports</a>, would prohibit “states from restricting a person’s ability to vote by mail.”
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But the bill appears dead on arrival in a divided Senate where at least 10 Republicans would need to support it to overcome an inevitable filibuster. Otherwise, political observers expect many of Georgia’s voting restrictions to pass into law, evidence that what Democrats call Trump’s <a href="https://www.vox.com/2021/2/28/22306318/trump-cpac-2021-speech-election-lies">“big lie</a>” will affect elections far into the future.
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<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gymnastics | Artistic All-Around World Cup in Tokyo cancelled due to COVID-19 impact</strong> - The event, which had been scheduled for May 4, was meant to conclude this year’s all-around series</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Delhi will bid for 2048 Olympic Games: Manish Sisodia</strong> - Delhi hosted the first Asian Games in 1951, and later the 1982 edition. In 2010, the national capital had hosted the Commonwealth Games.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ind vs SA | Mandhana, Goswami star as India level series with 9-wicket win in second ODI</strong> - Goswami took 4 wickets to restrict South Africa to 157 before Mandhana smashed 80 not out</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New Zealand skipper Williamson ruled out of Bangladesh series</strong> - Williamson, who led the ‘Black Caps’ to a 3-2 T20 series win over Australia on Sunday, has a small tear in his left elbow tendon</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Schwartzman claims Argentina Open title</strong> - It was a fourth ATP Tour title for the world number nine and top seed on the Buenos Aires clay</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>VACB exonerates Babu from bribery charges</strong> - He was charged with nepotism in awarding bar licences</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Political storm over Kolkata fire incident</strong> - BJP West Bengal co-incharge Amit Malviya in a tweet said, the State should equip local bodies with fire fighting equipment and put in place appropriate protocols</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India asks refiners to diversify, cut reliance on Middle East oil after OPEC+ decision</strong> - The country’s top refiner Indian Oil Corporation has renewed its oil import contract with Russia, they added. India hopes to resume Iranian oil imports this year, according to sources.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Student activist gets bail in case linked to CAA protests</strong> - His presence and movement could be controlled through suitable conditions, says HC</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Centre adamant on steel plant privatisation issue, alleges forum</strong> - ‘People should teach a lesson to BJP in municipal polls’</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Puigdemont: EU parliament lifts ex-Catalan leader’s immunity</strong> - Carles Puigdemont and two others are wanted in Spain over a failed independence referendum in 2017.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>France coronavirus: Paris cuts non-Covid treatment amid intensive care surge</strong> - Non-coronavirus care is reduced by 40% but a new lockdown is a “last resort”, officials say.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Samuel Paty: French schoolgirl admits lying about murdered teacher</strong> - The student admits she was not in class when Samuel Paty showed cartoons of the Prophet Muhammad.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>German MP Nikolas Löbel resigns over face mask scandal</strong> - Nikolas Löbel, from Angela Merkel’s party, quits after his firm made almost €250,000 from the deal.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>European Banking Authority hit by Microsoft Exchange hack</strong> - The EU body is one of the first major organisations to admit falling victim to the global email hack.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can $70 games succeed in a subscription-filled, free-to-play world?</strong> - It’s still early, but analysts say the “biggest franchises” can probably sustain $70. - <a href="https://arstechnica.com/?p=1747993">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gab, a haven for pro-Trump conspiracy theories, has been hacked again</strong> - A failure to purge authentication tokens taken in the first breach leads to a second one. - <a href="https://arstechnica.com/?p=1748174">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Chinese hackers targeted SolarWinds customers in parallel with Russian op</strong> - New data suggests that Russia wasn’t the only nation state hacking customers. - <a href="https://arstechnica.com/?p=1748111">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google tells harassment victims to take “medical leave,” report finds</strong> - Nearly two dozen current and former employees reported a widespread pattern. - <a href="https://arstechnica.com/?p=1747883">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Headphones without headphones: We test Lucyd Lyte Bluetooth sunglasses</strong> - Bluetooth sunglasses are a great idea—but these aren’t quite good enough. - <a href="https://arstechnica.com/?p=1747875">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
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<li><strong>John and his girlfriend Mary decide to become bank-robbers.</strong> - <!-- SC_OFF -->
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Mary does the actual robbing at gunpoint inside the banks while John waits outside as the getaway driver. They are initially successful with a string of heists that make headlines and they become folk-heroes. Until one day their luck runs out and they get caught.
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At trial, the judge condemns Mary to ten years in prison, while John gets two years. However, once they get to their respective prisons, they discover that due to a clerical error John will be serving ten years and Mary only two. Despite of her insistence, John convinces Mary to keep quiet about it.
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After two years Mary gets out and she continues to visit John faithfully every month and they exchange letters and phone calls regularly for the remainder of his ten years.
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Finally, after he does his time, John gets out and is joyfully reunited with Mary. They get married and move to a different state and start anew, leaving their life of crime behind. They raise a family with children and grandchildren and eventually reach old age, after having lived a happy marriage.
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On their 50th wedding anniversary party, the entire family and friends are gathered. A great celebration is had, with many laughs and stories, recounting their life together.
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The conversation turns to the secrets to a happy marriage. One of the guests asks Mary why she decided to stick with John while he was in prison, despite all of the hardships.
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Mary answers: “Well… you know you have found the One when you finish each other’s sentences.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/InkaGold"> /u/InkaGold </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/m0w96l/john_and_his_girlfriend_mary_decide_to_become/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/m0w96l/john_and_his_girlfriend_mary_decide_to_become/">[comments]</a></span></p></li>
<li><strong>How many Buzzfeed writers does it take to turn on an electric chair?</strong> - <!-- SC_OFF -->
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Ten. But number four will shock you.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/JesusSaves002"> /u/JesusSaves002 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/m0j6jy/how_many_buzzfeed_writers_does_it_take_to_turn_on/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/m0j6jy/how_many_buzzfeed_writers_does_it_take_to_turn_on/">[comments]</a></span></p></li>
<li><strong>Did you hear? There’s this app that lets you see which of your family members would have been nazis in WWII…</strong> - <!-- SC_OFF -->
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It’s called Facebook.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Apiperofhades"> /u/Apiperofhades </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/m0jh92/did_you_hear_theres_this_app_that_lets_you_see/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/m0jh92/did_you_hear_theres_this_app_that_lets_you_see/">[comments]</a></span></p></li>
<li><strong>A man was dumping toxic waste into a river.</strong> - <!-- SC_OFF -->
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Suddenly, the sky darkened, lightning flashed, and a glowing woman appeared, hovering above the river.
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<strong>“For your crimes, I curse you to only speak in words related to water!”,</strong> she intoned, and then vanished in another flash of lightning.
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The man stood, shocked, before gathering his wits and muttering, “Well dam”.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/L_Circe"> /u/L_Circe </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/m0z80w/a_man_was_dumping_toxic_waste_into_a_river/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/m0z80w/a_man_was_dumping_toxic_waste_into_a_river/">[comments]</a></span></p></li>
<li><strong>A legal representative of KFC manages to arrange a meeting with the Pope.</strong> - <!-- SC_OFF -->
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After receiving the papal blessing, he whispers, “Your eminence, we have an offer for you. KFC is prepared to donate $100 million dollars to the church if you change the Lord’s Prayer from <em>give us this day our daily bread</em> to <em>give us this day our daily</em> <strong>chicken</strong>”.
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The Pope responds, “That is impossible. The Prayer is the word of the Lord - it must not be changed.” “Well,” says the KFC man, “we anticipated your reluctance. For this reason, we will increase our offer to $300 million dollars. All we require is that you change the Lord’s Prayer from <em>give us this day our daily bread</em> to <em>give us this day our daily</em> <strong>chicken</strong>”.
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Again, the Pope replies, “That, my son, is impossible. For the prayer is the word of the Lord and it must not be changed.” Finally, the KFC guy says, “Your Holiness, we at KFC respect your adherence to your faith, but we do have one final offer. We will donate $500 million dollars - that’s half a billion dollars - to the great Catholic Church if you would only change the Lord’s Prayer from <em>give us this day our daily bread</em> to <em>give us this day our daily</em> <strong>chicken</strong>. Please consider it.” And he leaves.
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The next day the Pope convenes the College of Cardinals. “There is some good news,” he announces, “and some bad news.” “The good news is that the Church has come into $500 million dollars.”
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“And the bad news, your eminence?” asks a Cardinal. “We’re losing the Wonderbread account.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/PedroFPardo"> /u/PedroFPardo </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/m0ky9j/a_legal_representative_of_kfc_manages_to_arrange/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/m0ky9j/a_legal_representative_of_kfc_manages_to_arrange/">[comments]</a></span></p></li>
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