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<title>18 June, 2021</title>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Facilitating Informed Decision Making: Determinants of University Students’ COVID-19 Vaccine Uptake</strong> -
<div>
Objective: Although several COVID-19 vaccines are available, the current challenge is achieving high vaccine uptake. We aimed to explore university students’ intention to get vaccinated and select the most relevant determinants/beliefs to facilitate informed decision-making around COVID-19 vaccine uptake. Methods: A cross-sectional online survey with students (N = 434) from Maastricht University was conducted in March 2021. The most relevant determinants/beliefs of students’ COVID-19 vaccine intention (i.e., determinants linked to vaccination intention, and with enough potential for change) were visualized using CIBER plots. Results: Students’ intention to get the COVID-19 vaccine is high (80 %). Concerns about safety and side effects of the vaccine and trust in government, quality control, and the pharmaceutical industry are identified as the most relevant determinants of vaccine intention. Other predictors are risk perception, attitude, perceived norm, and self-efficacy beliefs. Conclusion: Our study identified several predictors of COVID-19 vaccine intention (e.g., safety, trust, risk perception, etc.) and helped to select the most relevant determinants/beliefs to target in an intervention to maximize the COVID-19 uptake. Where concerns and trust related to the COVID-19 vaccine are the most important target for future interventions, other determinants that were already positive (i.e., risk perception, attitudes, perceived norms, and self-efficacy) could be further confirmed.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/u46bm/" target="_blank">Facilitating Informed Decision Making: Determinants of University Students’ COVID-19 Vaccine Uptake</a>
</div></li>
<li><strong>Out-of-Pocket Spending for Health Care Within 90 Days of COVID-19 Hospitalization</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
INTRODUCTION: Millions of U.S. patients have been hospitalized for coronavirus disease 2019 (COVID-19). After discharge, these patients often have extensive health care needs, but out-of-pocket burden for this care is poorly described. Using national data, we assessed out-of-pocket spending during the 90 days after COVID-19 hospitalization among privately insured and Medicare Advantage patients. METHODS: In May 2021, we conducted a cross-sectional analysis of the IQVIA PharMetrics Plus for Academics Database, a national de-identified claims database. Among privately insured and Medicare Advantage patients hospitalized for COVID-19 between March-June 2020, we calculated mean out-of-pocket spending for care within 90 days of discharge. To contextualize results, we repeated analyses for patients hospitalized for bacterial pneumonia. RESULTS: Among 1,465 COVID-19 patients included, 516 (35.2%) and 949 (64.8%) were covered by private insurance and Medicare Advantage plans. Among these patients, mean (SD) post-discharge out-of-pocket spending was $534 (1,045) and $680 (1,360); spending exceeded $2,000 for 7.0% and 10.3%. Compared with patients with pneumonia, mean post-discharge out-of-pocket spending among COVID-19 patients was higher among the privately insured ($534 vs $445) and lower among Medicare Advantage patients ($680 vs $918). CONCLUSIONS: Out-of-pocket spending for immediate post-discharge care can be substantial for many patients hospitalized for COVID-19. Among Medicare Advantage patients, post-discharge out-of-pocket spending was higher after pneumonia hospitalizations, potentially because insurer cost-sharing waivers fully covered the costs of COVID-19-related readmissions during the study period. As many insurers allowed such waivers to expire in 2021, it is important to repeat analyses among patients more recently hospitalized for COVID-19.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.06.11.21258766v2" target="_blank">Out-of-Pocket Spending for Health Care Within 90 Days of COVID-19 Hospitalization</a>
</div></li>
<li><strong>Phylogenomics and population genomics of SARS-CoV-2 in Mexico reveals variants of interest (VOI) and a mutation in the Nucleocapsid protein associated with symptomatic versus asymptomatic carriers</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Understanding the evolution of SARS-CoV-2 virus in various regions of the world during the Covid19 pandemic is essential to help mitigate the effects of this devastating disease. We describe the phylogenomic and population genetic patterns of the virus in Mexico during the pre-vaccination stage, including asymptomatic carriers. A RT-qPCR screening and phylogenomics reconstructions directed a sequence/structure analysis of the Spike glycoprotein, revealing mutation of concern E484K in genomes from central Mexico, in addition to the nationwide prevalence of the imported variant 20C/S:452R (B.1.427/9). Overall, the detected variants in Mexico show Spike protein mutations in the N-terminal domain (i.e., R190M), in the receptor-binding motif (i.e., T478K, E484K), within the S1-S2 subdomains (i.e., P681R/H, T732A), and at the basis of the protein, V1176F, raising concerns about the lack of phenotypic and clinical data available for the variants of interest (VOI) we postulate: 20B/478K.V1 (B.1.1.222 or B.1.1.519) and 20B/P.4 (B.1.1.28.4). Moreover, the population patterns of Single Nucleotide Variants (SNVs) from symptomatic and asymptomatic carriers obtained with a self-sampling scheme confirmed the presence of several fixed variants, and differences in allelic frequencies among localities. We identified the mutation N:S194L of the Nucleocapsid protein associated with symptomatic patients. Phylogenetically, this mutation is frequent in Mexican sub-clades, so we propose an additional VOI, 20A/N:194L.V2 (B.1.243). Our results highlight the dual and complementary role of Spike and Nucleocapsid proteins in adaptive evolution of SARS-CoV-2 to their hosts and provide a baseline for specific follow-up of mutations of concern during the vaccination stage.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.05.18.21256128v2" target="_blank">Phylogenomics and population genomics of SARS-CoV-2 in Mexico reveals variants of interest (VOI) and a mutation in the Nucleocapsid protein associated with symptomatic versus asymptomatic carriers</a>
</div></li>
<li><strong>COVID-19 Outcomes and Sequencing of SARS-CoV-2 isolated from Veterans in New England</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Clinical and virologic characteristics of COVID-19 infections in veterans in New England have not been described. Objectives: To evaluate clinical and virologic factors impacting COVID-19 outcomes. Study Design: We reviewed charts and sequenced virus from nasopharyngeal specimens with confirmed SARS-CoV-2 from 426 veterans in six New England states between April and September, 2020. Peak disease severity, hospitalization, and mortality were correlated to clinical, demographic, and virologic factors. Results: Of 426 veterans, 274 had complete and accessible charts. 92.7% were men, 83.2% White, with mean age 63 years. On multivariate regression, significant predictors of hospitalization were age (OR: 1.05) and non-white race (OR: 2.39). Mortality and peak disease severity varied by age (OR 1.06 and 1.07 respectively) and oxygen requirement on admission (OR6.74 and 45.7). Dementia (OR: 3.44) was also associated with mortality. Most (97.3%) of our samples were dominated by the spike protein D614G substitution, and were from SARS-CoV-2 B.1 lineage or one of 37 different B.1 sub-lineages, with none representing more than 8.7% of the cases. Conclusions: In an older cohort of veterans from the six New England states with a high comorbidity burden, age was the largest predictor of hospitalization, peak disease severity, and mortality. Non-white veterans were more likely to be hospitalized, and patients who required oxygen on admission were more likely to have severe disease and higher rates of mortality. Multiple SARS-CoV-2 lineages were distributed in patients in New England early in the COVID-19 era, mostly related to viruses from New York with D614G mutation.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.04.27.21256222v3" target="_blank">COVID-19 Outcomes and Sequencing of SARS-CoV-2 isolated from Veterans in New England</a>
</div></li>
<li><strong>Quantifying the Benefits of Targeting for Pandemic Response</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
To respond to pandemics such as COVID-19, policy makers have relied on interventions that target specific age groups or activities. Such targeting is potentially contentious, so rigorously quantifying its benefits and downsides is critical for designing effective and equitable pandemic control policies. We propose a flexible modeling framework and algorithms to compute optimally targeted interventions that coordinate across two dimensions of heterogeneity: age of different groups and the specific activities that individuals engage in during the course of a day. We showcase a complete implementation in a case study focused on the COVID-19 epidemic in the Île-de-France region of France, based on hospitalization, community mobility, social contacts and economic data. We find that optimized dual-targeted policies generate substantial complementarities that lead to Pareto improvements, reducing the number of deaths and the economic losses overall and reducing the time in confinement for each age group, compared to less targeted interventions. These policies have a simple and explainable structure. Since dual-targeted policies could lead to increased discrepancies in the confinements faced by distinct groups, we also quantify the impact of requirements that explicitly limit such disparities, and find that satisfactory trade-offs may be achievable through limited targeting.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.03.23.21254155v3" target="_blank">Quantifying the Benefits of Targeting for Pandemic Response</a>
</div></li>
<li><strong>Estimation and worldwide monitoring of the effective reproductive number of SARS-CoV-2</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The effective reproductive number Re is a key indicator of the growth of an epidemic. Since the SARS-CoV-2 pandemic started, many methods and online dashboards have sprung up to monitor this number. However, these methods are not always thoroughly tested or are applied only to a limited geographic range. Here, we present a method for near real time monitoring of Re, applied to epidemic data from 170 countries. We thoroughly validate the method on simulated data, and present an intuitive web interface for interactive data exploration. We show that in the majority of countries the estimated Re dropped below 1 only after the introduction of major non-pharmaceutical interventions. For Europe, Asia, and North America we found that the implementation of non-pharmaceutical interventions was associated with reductions in the effective reproductive number. Globally, we found that relaxing non-pharmaceutical interventions did not fully revert Re values to their original levels. Generally, our framework is useful both to inform governments and the general public on the status of the epidemic in their country, as well as a source for detailed comparison between countries and in relation to local public health policies and external covariates such as mobility, behavioural, or weather data.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.11.26.20239368v2" target="_blank">Estimation and worldwide monitoring of the effective reproductive number of SARS-CoV-2</a>
</div></li>
<li><strong>Implementation of ICT tools to improve the object-oriented distance education in India: A perspective</strong> -
<div>
India, being a country with a majority youth population, has a good opportunity to strengthen its economy in the next few decades. However, this could only be possible, if the youth population is trained with the required skill-set for the job market with improved opportunities for higher education. Unfortunately, the percentage of higher education enrolment does not possess encouraging numbers due to various social &amp; economic reasons. The ratio in the coming years can be improved by offering the higher education courses in open &amp; distance learning mode (ODL). Recently University Grants Commission (UGC also eased the norms for the higher educational institutes to offer ODL programs. However, the present ODL programs that are being offered were challenged with (i) lack of quality checks (ii) lack of paradigm shift in the course delivery, which is still through correspondence mode (iii) the degrees offered by the distance mode are not on par with regular courses. In this view, it is time to assess the quality of the present ODL programs and the necessary steps have to be initiated to improve the quality of the program. Due to the COVID 19 pandemic condition, major parts of the world dependent on online classes for the delivery of the regular courses, in this view, various tools for delivery and assessment are being widely used/developed. The integration of these tools with the present corresponding courses shall improve the quality of the courses. Herein, we comprehensively present the above-mentioned problems and solutions to improve the quality of ODL courses in India.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/6b7su/" target="_blank">Implementation of ICT tools to improve the object-oriented distance education in India: A perspective</a>
</div></li>
<li><strong>A Comprehensive Analysis and prognostication of COVID-19 (SARS-Cov-2) Outbreak situation in India</strong> -
<div>
Covid-19 is an infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in late December 2019 in China and later spread worldwide. The first case of Covid-19 was diagnosed in the last week of January 2020, India. Subsequently, the number of cases drastically rose. As of May 11, 2021, in India, 2,33,40,375 positive cases have been reported, out of which 1,93,76,561 recovered and 2,53,634 death were reported as per covid19india report. To avail in designing better strategies and in making effective decisions, we can use forecasting techniques. These techniques assess the past situation, thereby enabling better prognostications about the situation to occur in the future. Based on these time series modeling, this paper tries to study the prediction of Covid-19 in terms of total substantiated, recovered, and death cases. It also examines the daily infected, active, recovery, and death cases. The correlation coefficients and sarimax forecasting model were applied for prediction and statistical measures used for population variance equality.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/v9n7s/" target="_blank">A Comprehensive Analysis and prognostication of COVID-19 (SARS-Cov-2) Outbreak situation in India</a>
</div></li>
<li><strong>Western diet increases COVID-19 disease severity in the Syrian hamster</strong> -
<div>
Pre-existing comorbidities such as obesity or metabolic diseases can adversely affect the clinical outcome of COVID-19. Chronic metabolic disorders are globally on the rise and often a consequence of an unhealthy diet, referred to as a Western Diet. For the first time in the Syrian hamster model, we demonstrate the detrimental impact of a continuous high-fat high-sugar diet on COVID-19 outcome. We observed increased weight loss and lung pathology, such as exudate, vasculitis, hemorrhage, fibrin, and edema, delayed viral clearance and functional lung recovery, and prolonged viral shedding. This was accompanied by an increased trend of systemic IL-10 and IL-6, as well as a dysregulated serum lipid response dominated by polyunsaturated fatty acid-containing phosphatidylethanolamine, recapitulating cytokine and lipid responses associated with severe human COVID-19. Our data support the hamster model for testing restrictive or targeted diets and immunomodulatory therapies to mediate the adverse effects of metabolic disease on COVID-19.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.17.448814v1" target="_blank">Western diet increases COVID-19 disease severity in the Syrian hamster</a>
</div></li>
<li><strong>A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice</strong> -
<div>
As SARS-CoV-2 continues to cause morbidity and mortality around the world, there is an urgent need for the development of effective medical countermeasures. Here, we assessed the antiviral capacity of a minimal RIG-I agonist, stem-loop RNA 14 (SLR14), in viral control, disease prevention, post-infection therapy, and cross-variant protection in mouse models of SARS-CoV-2 infection. A single dose of SLR14 prevented viral replication in the lower respiratory tract and development of severe disease in a type I interferon (IFN-I) dependent manner. SLR14 demonstrated remarkable protective capacity against lethal SARS-CoV-2 infection when used prophylactically and retained considerable efficacy as a therapeutic agent. In immunodeficient mice carrying chronic SARS-CoV-2 infection, SLR14 elicited near-sterilizing innate immunity by inducing IFN-I responses in the absence of the adaptive immune system. In the context of infection with variants of concern (VOC), SLR14 conferred broad protection and uncovered an IFN-I resistance gradient across emerging VOC. These findings demonstrate the therapeutic potential of SLR14 as a host-directed, broad-spectrum antiviral for early post-exposure treatment and for treatment of chronically infected immunosuppressed patients.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.16.448754v1" target="_blank">A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice</a>
</div></li>
<li><strong>Designing a Novel Multi-Epitope Vaccine against SARS-CoV-2; Implication for Viral Binds and Fusion Inhibition through Inducing Neutralizing Antibodies</strong> -
<div>
Recently the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a pervasive threat to public health so it is an emergency to vaccine development. The SARS-CoV-2 spike (S) glycoprotein plays a vital role in binds and fusion to the angiotensin-converting enzyme 2 (ACE2). The multi-epitope peptide vaccines are capable of inducing the specific humoral or cellular immune responses. In this regard, the RBD and spike cleavage site is the most probable target for vaccine development to inducing binds and fusion inhibitors neutralizing antibodies. In the present study, several immunoinformatics tools are used for analyzing the spike (S) glycoprotein sequence including the prediction of the potential linear B-cell epitopes, B-cell multi-epitope design, secondary and tertiary structures, physicochemical properties, solubility, antigenicity, and allergenicity for the promising vaccine candidate against SARS-CoV-2.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.06.16.448772v1" target="_blank">Designing a Novel Multi-Epitope Vaccine against SARS-CoV-2; Implication for Viral Binds and Fusion Inhibition through Inducing Neutralizing Antibodies</a>
</div></li>
<li><strong>The Development of Digital MSME in the Covid-19 Pandemic</strong> -
<div>
The global Covid-19 pandemic that has plagued all countries of the world has affect all sectors of people’s lives. In Indonesia, almost all sectors experience impacts, especially the economic ecosystem which has been become the focus of society. Furthermore, the Covid-19 pandemic has made the slowdown in the economic sector in Indonesia with its various derivatives. The Micro, Small and Medium Enterprises (MSME) sector which is part of the most important sector of the economy is very important feel. This is what worried by all parties, because it has made the MSME sector experienced a significant decline. Moreover, currently many MSMEs are experiencing various problems such as: decrease in sales, capital, hampered distribution, difficulty in raw materials, decreased production and the occurrence of many layoffs for workers and hunting which later became a threat to the national economy. MSMEs as a driver of the domestic economy and a middle labor absorber face a decline in productivity which results in a decrease in profits significant. Even based on the related Asian Development Bank (ADB) survey, the impact of the pandemic on MSMEs in Indonesia, 88% of micro businesses run out of cash or savings, and more than 60% of these micro and small enterprises have reduced their workforce work.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/zu3hd/" target="_blank">The Development of Digital MSME in the Covid-19 Pandemic</a>
</div></li>
<li><strong>How scientific reasoning correlates with health-related beliefs and behaviors during the COVID-19 pandemic?</strong> -
<div>
We examined whether scientific reasoning is associated with health-related beliefs and behaviors over and above general analytic thinking ability in the general public (N = 783, aged 18–84). Health-related beliefs included: anti-vaccination attitudes, COVID-19 conspiracy beliefs, and generic health-related epistemically suspect beliefs. Scientific reasoning correlated with generic pseudoscientific and health-related conspiracy beliefs and COVID-19 conspiracy beliefs. Crucially, scientific reasoning was a stronger independent predictor of unfounded beliefs (including anti-vaccination attitudes) than general analytic thinking was; however, it had a more modest role in health-related behaviors.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/tfy5q/" target="_blank">How scientific reasoning correlates with health-related beliefs and behaviors during the COVID-19 pandemic?</a>
</div></li>
<li><strong>The Development of Digital in the Covid-19 Pandemic</strong> -
<div>
The global Covid-19 pandemic that has plagued all countries of the world has affect all sectors of people’s lives. In Indonesia, almost all sectors experience impacts, especially the economic ecosystem which has been become the focus of society. Furthermore, the Covid-19 pandemic has made the slowdown in the economic sector in Indonesia with its various derivatives. The Micro, Small and Medium Enterprises (MSME) sector which is part of the most important sector of the economy is very important feel. This is what worried by all parties, because it has made the MSME sector experienced a significant decline. Moreover, currently many MSMEs are experiencing various problems such as: decrease in sales, capital, hampered distribution, difficulty in raw materials, decreased production and the occurrence of many layoffs for workers and hunting which later became a threat to the national economy. MSMEs as a driver of the domestic economy and a middle labor absorber face a decline in productivity which results in a decrease in profits significant. Even based on the related Asian Development Bank (ADB) survey, the impact of the pandemic on MSMEs in Indonesia, 88% of micro businesses run out of cash or savings, and more than 60% of these micro and small enterprises have reduced their workforce work.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/p6sqg/" target="_blank">The Development of Digital in the Covid-19 Pandemic</a>
</div></li>
<li><strong>The Development of Digital in the Covid-19 Pandemic</strong> -
<div>
The global Covid-19 pandemic that has plagued all countries of the world has affect all sectors of people’s lives. In Indonesia, almost all sectors experience impacts, especially the economic ecosystem which has been become the focus of society. Furthermore, the Covid-19 pandemic has made the slowdown in the economic sector in Indonesia with its various derivatives. The Micro, Small and Medium Enterprises (MSME) sector which is part of the most important sector of the economy is very important feel. This is what worried by all parties, because it has made the MSME sector experienced a significant decline. Moreover, currently many MSMEs are experiencing various problems such as: decrease in sales, capital, hampered distribution, difficulty in raw materials, decreased production and the occurrence of many layoffs for workers and hunting which later became a threat to the national economy. MSMEs as a driver of the domestic economy and a middle labor absorber face a decline in productivity which results in a decrease in profits significant. Even based on the related Asian Development Bank (ADB) survey, the impact of the pandemic on MSMEs in Indonesia, 88% of micro businesses run out of cash or savings, and more than 60% of these micro and small enterprises have reduced their workforce work.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/djrn6/" target="_blank">The Development of Digital in the Covid-19 Pandemic</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ivermectin Treatment Efficacy in Covid-19 High Risk Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Ivermectin 0.4mg/kg/day for 5 days<br/><b>Sponsor</b>:   Clinical Research Centre, Malaysia<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>To Evaluate the Safety and Efficacy of TQ Formula in Covid-19 Participants</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Black Seed Oil Cap/Tab<br/><b>Sponsor</b>:   Novatek Pharmaceuticals<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of XAV-19 for the Treatment of Moderate-to-severe COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: XAV-19;   Drug: Placebo<br/><b>Sponsor</b>:   Xenothera SAS<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intramuscular VIR-7831 (Sotrovimab) for Mild/Moderate COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: VIR-7831<br/><b>Sponsors</b>:   Vir Biotechnology, Inc.;   GlaxoSmithKline<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Trial With N-acetylcysteine and Bromhexine for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Vitamin C;   Drug: N-acetylcysteine (NAC);   Drug: NAC + Bromhexine (BMX)<br/><b>Sponsors</b>:   Universidade Federal do Ceara;   Paulista School of Medicine-EPM, UNIFESP;   Health Surveillance Secretariat - SVS;   Central Laboratory of Public Health of Ceara - LACEN-CE;   Leonardo da Vinci Hospital - HLV;   São José Hospital for Infectious Diseases - HSJ;   Ceará Health Secretariat - SESA;   Municipal Health Secretary - SMS-Fortaleza<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Augmentation of Immune Response to COVID-19 mRNA Vaccination Through OMT With Lymphatic Pumps</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Osteopathic Manipulative Treatment (OMT)<br/><b>Sponsors</b>:   Western University of Health Sciences;   American College of Osteopathic Physicians;   American Osteopathic Foundation;   Osteopathic Physicians and Surgeons of California;   Xavier-Nichols Foundation<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nervous System Symptoms Associated With COVID 19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: NEURO +;   Other: NEURO -<br/><b>Sponsor</b>:   University Hospital, Toulouse<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Open Label, Single-Center Study Utilizing BIOZEK COVID-19 Antigen Rapid Test</strong> - <b>Condition</b>:   Covid-19 Testing<br/><b>Intervention</b>:   Diagnostic Test: Biozek Covid-19 Antigen Rapid Test (Saliva)<br/><b>Sponsor</b>:   Mach-E B.V.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Burden of COVID-19 Survivorship</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Exercise Training<br/><b>Sponsor</b>:   Mayo Clinic<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Community-based Post-exposure Prophylaxis for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Guduchi Ghanvati;   Other: Standard guidelines<br/><b>Sponsors</b>:   NMP Medical Research Institute;   Aarogyam UK;   Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University;   Samta Ayurveda Prakoshtha, India;   Padmanabhama Ayurveda Hospital and Research Centre<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vitamin A Supplementation in Children With Moderate to Severe Covid-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Dietary Supplement: Vitamin A supplement<br/><b>Sponsor</b>:   Shiraz University of Medical Sciences<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Favipiravir +/- Nitazoxanide: Early Antivirals Combination Therapy in COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Favipiravir;   Drug: Nitazoxanide;   Other: Nitazoxanide Placebo<br/><b>Sponsors</b>:   Coordinación de Investigación en Salud, Mexico;   University College, London;   Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional (CINVESTAV);   Universidad Autonoma de Guadalajara;   Siegfried Rhein S.A. de C.V.;   Strides Pharma Science Limited;   Hakken Enterprise<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Efficacy of Dupilumab for Treatment of Hospitalized COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: Dupilumab;   Drug: Placebo<br/><b>Sponsors</b>:   University of Virginia;   PBM C19 Research, LLC (PBM);   Virginia Catalyst, Virginia Biosciences Health Research Corporation (VBHRC)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impact of Moderate Exercise Training on Vitals and Peak VO2 in Different Age Categories of Adult in COVID-19.</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Other: Moderate Exercise Training (Age Group 1; Young adult 17 -30 years);   Other: Moderate Exercise Training (Age Group 2; 31 to 45 years);   Other: Moderate Exercise Training (Age Group 3; Above 45 years)<br/><b>Sponsor</b>:   Riphah International University<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Infliximab in the Treatment of Patients With Severe COVID-19 Disease</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Infliximab;   Other: Standard of Care<br/><b>Sponsors</b>:   Jena University Hospital;   German Federal Ministry of Education and Research;   Celltrion<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants</strong> - The SARS-CoV-2 variants replacing the first wave strain pose an increased threat by their potential ability to escape pre-existing humoral protection. An angiotensin converting enzyme 2 (ACE2) decoy that competes with endogenous ACE2 for binding of the SARS-CoV-2 spike receptor binding domain (S RBD) and inhibits infection may offer a therapeutic option with sustained efficacy against variants. Here, we used Molecular Dynamics (MD) simulation to predict ACE2 sequence substitutions that might…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Melatonin and other indoles show antiviral activities against swine Coronaviruses in vitro at pharmacological concentrations</strong> - The current coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlights major gaps in our knowledge on the prevention control and cross-species transmission mechanisms of animal coronaviruses. Transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), and porcine delta-coronavirus (PDCoV) are three common swine coronaviruses and have similar clinical features. In absence of effective treatments, they…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection</strong> - Coronavirus infection induces the unfolded protein response (UPR), a cellular signalling pathway composed of three branches, triggered by unfolded proteins in the endoplasmic reticulum (ER) due to high ER load. We have used RNA sequencing and ribosome profiling to investigate holistically the transcriptional and translational response to cellular infection by murine hepatitis virus (MHV), often used as a model for the Betacoronavirus genus to which the recently emerged SARS-CoV-2 also belongs….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phenolic compounds disrupt spike-mediated receptor-binding and entry of SARS-CoV-2 pseudo-virions</strong> - In the pursuit of suitable and effective solutions to SARS-CoV-2 infection, we investigated the efficacy of several phenolic compounds in controlling key cellular mechanisms involved in its infectivity. The way the SARS-CoV-2 virus infects the cell is a complex process and comprises four main stages: attachment to the cognate receptor, cellular entry, replication and cellular egress. Since, this is a multi-part process, it creates many opportunities to develop effective interventions. Targeting…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Laboratory testing for suspected COVID-19 vaccine-induced (immune) thrombotic thrombocytopenia</strong> - COVID-19 (coronavirus disease 2019) represents a pandemic, and several vaccines have been produced to prevent infection and/or severe sequelae associated with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. There have been several reports of infrequent post vaccine associated thrombotic events, in particular for adenovirus-based vaccines. These have variously been termed VIPIT (vaccine-induced prothrombotic immune thrombocytopenia), VITT (vaccine-induced [immune]…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An in vitro antiviral activity of iodine complexes against SARS-CoV-2</strong> - Since the emergence of COVID-19 pandemic in China in late 2019, scientists are striving hard to explore non-toxic, viable anti-SARS-CoV-2 compounds or medicines. We determined In vitro anti-SARS-CoV-2 activity of oral formulations (syrup and capsule)of an Iodine-complex (Renessans). First, cell cytotoxicity of Renessans on the Vero cells was determined using MTT assay. Afterwards, the antiviral activity of Renessans was determined using viral inhibition assays and TCID(50). For this, nontoxic…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Correction to “Synergistic Inhibition of SARS-CoV-2 Replication Using Disulfiram/Ebselen and Remdesivir”</strong> - [This corrects the article DOI: 10.1021/acsptsci.1c00022.].</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potent Molecular Feature-based Neutralizing Monoclonal Antibodies as Promising Therapeutics Against SARS-CoV-2 Infection</strong> - The 2019-2020 winter was marked by the emergence of a new coronavirus (SARS-CoV-2) related disease (COVID-19), which started in Wuhan, China. Its high human-to-human transmission ability led to a worldwide spread within few weeks and has caused substantial human loss. Mechanical antiviral control approach, drug repositioning, and use of COVID-19 convalescent plasmas (CPs) were the first line strategies utilized to mitigate the viral spread, yet insufficient. The urgent need to contain this…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Humoral Response after SARS-Cov-2 mRNA Vaccine in a Cohort of Hemodialysis Patients and Kidney Transplant Recipients</strong> - Background Kidney transplant recipients and patients receiving hemodialysis are immunocompromised populations that are prioritized for COVID-19 vaccination but were excluded from clinical trials of SARS-CoV-2 mRNA vaccines. Antibody titers and rates of seroconversion following vaccination are lower among patients with chronic kidney disease and those taking immunosuppressants compared with controls. Data are lacking regarding their humoral response to vaccination to prevent COVID-19. Methods…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity</strong> - Infection by highly pathogenic coronaviruses results in substantial apoptosis. However, the physiological relevance of apoptosis in the pathogenesis of coronavirus infections is unknown. Here, with a combination of in vitro, ex vivo, and in vivo models, we demonstrated that protein kinase R-like endoplasmic reticulum kinase (PERK) signaling mediated the proapoptotic signals in Middle East respiratory syndrome coronavirus (MERS-CoV) infection, which converged in the intrinsic apoptosis pathway….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Higher Levels of Harsh Parenting During the COVID-19 Lockdown in the Netherlands</strong> - Previous studies on the impact of COVID-19 indicate that pandemic-related distress increases risks for child maltreatment, although data on the scope of this problem are still scarce. Here, we assessed whether parents with toddlers (n = 206) more often used harsh discipline during the lockdown in the Netherlands compared to a matched parent sample collected prior to the pandemic (n = 1,030). Parents were matched on background characteristics using propensity score matching. We found that harsh…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Humoral and cellular immune responses against SARS-CoV-2 variants and human coronaviruses after single BNT162b2 vaccination</strong> - CONCLUSION: These results call into question whether neutralizing antibodies significantly contribute to protection against COVID-19 upon single vaccination and suggest that cellular immunity is central for the early defenses against COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1</strong> - Nonstructural protein 1 (Nsp1) of severe acute respiratory syndrome coronaviruses (SARS-CoVs) is an important pathogenic factor that inhibits host protein translation by means of its C terminus. However, its N-terminal function remains elusive. Here, we determined the crystal structure of the N terminus (amino acids [aa] 11 to 125) of SARS-CoV-2 Nsp1 at a 1.25-Å resolution. Further functional assays showed that the N terminus of SARS-CoVs Nsp1 alone loses the ability to colocalize with ribosomes…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>alpha(V) beta(6) Integrin: An Intriguing Target for COVID-19 and Related Diseases</strong> - The outbreak of SARS-CoV-2 has been an extraordinary event that constituted a global health emergency. As the novel coronavirus is continuing to spread over the world, the need for therapeutic agents to control this pandemic is increasing. α(V) β(6) Integrin may be an intriguing target not only for the inhibition of SARS-CoV-2 entry, but also for the diagnosis/treatment of COVID-19 related fibrosis, an emerging type of fibrotic disease which will probably affect a significant part of the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A comprehensive review of the therapeutic potential of curcumin nanoformulations</strong> - Today, due to the prevalence of various diseases such as the novel coronavirus (SARS-CoV-2), diabetes, central nervous system diseases, cancer, cardiovascular disorders, and so on, extensive studies have been conducted on therapeutic properties of natural and synthetic agents. A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>폐마스크 밀봉 회수기</strong> - 본 발명은 마스크 착용 후 버려지는 일회용 폐마스크를 비닐봉지에 넣은 후 밀봉하여 배출함으로써, 2차 감염을 예방하고 일반 생활폐기물과 선별 분리 배출하여 환경오염을 방지하는 데 그 목적이 있다. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=KR325788342">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COST EFFECTIVE PORTABLE OXYGEN CONCENTRATOR FOR COVID-19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU324964715">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA)</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323956811">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Erweiterbare Desinfektionsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Erweiterbare Desinfektionsvorrichtung, umfassend: einen Hauptkörper, der eine umgekehrt U-förmige Basisplatte aufweist, wobei die umgekehrt U-förmige Basisplatte mit einer Öffnung versehen ist und jeweils eine Seitenplatte sich von zwei Seiten der umgekehrt U-förmigen Basisplatte nach außen erstreckt; und mindestens eine Desinfektionslampe, die in den auf zwei Seiten des Hauptkörpers befindlichen Seitenplatten angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402480">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Einfache Sterilisationsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Einfache Sterilisationsvorrichtung, mit einem Hauptkörper (11), der in Längsrichtung einen ersten Plattenabschnitt (111) und in Querrichtung einen zweiten Plattenabschnitt (112) aufweist, wobei der erste Plattenabschnitt (111) und der zweite Plattenabschnitt (112) L-förmig miteinander verbunden sind; und einer Sterilisationslampe (12), die an dem Hauptkörper (11) angeordnet ist und eine Lichtemissionseinheit (121), eine Sensoreinheit (122), eine Steuereinheit (123) und eine Stromeinheit (124) aufweist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402479">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Klemmarme aufweisende Desinfektionsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Klemmarme aufweisende Desinfektionsvorrichtung, umfassend: einen Hauptkörper; eine Desinfektionslampe, die im Hauptkörper angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst; einen Klemmabschnitt, der auf einer Seite des Hauptkörpers angeordnet ist, wobei der Klemmabschnitt zwei gegenüberliegende Greifbacken umfasst, wobei mindestens eine der beiden Greifbacken mit einer Schwenkachse versehen ist, wobei ein Klemmraum durch passgenaues Schließen der beiden Greifbacken entsteht und die beiden Greifbacken jeweils mit einem Durchgangsloch versehen sind; einen Befestigungsabschnitt, der durch die Durchgangslöcher der beiden Greifbacken hindurchgeführt ist;und ein Schild, das auf einer Seite des Klemmabschnitts angeordnet und mit einem Aufnahmeloch versehen ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402478">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Aufhängbare Sterilisationsvorrichtung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Aufhängbare Sterilisationsvorrichtung, mit einem Hauptkörper (11); einer Sterilisationslampe (12), die an dem Hauptkörper (11) angeordnet ist und eine Lichtemissionseinheit (121), eine Sensoreinheit (122), eine Steuereinheit (123) und eine Stromeinheit (124) aufweist; einem Klemmabschnitt (13), der an einer Seite des Hautpkörpers (11) angeordnet ist und zwei gegenüberliegend angeordnete Klemmbacken (131) aufweist, wobei mindestens eine der beiden Klemmbacken (131) mit einem Achsbolzen (132) versehen ist, wobei die beiden Klemmbacken (131) beim Schließen einen Klemmraum (134) bilden, und wobei die beiden Klemmbacken (131) jeweils mit einem Durchgangsloch (135) versehen sind; und einem Befestigungselement (14), das durch die Durchgangslöcher (135) der beiden Klemmbacken (131) hindurchgeführt wird.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402477">link</a></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sterilisationsvorrichtung zur Verbesserung der Desinfektionswirkung</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
</p><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">Sterilisationsvorrichtung zur Verbesserung der Desinfektionswirkung, umfassend: einen Hauptkörper, der eine erste Oberfläche, eine von der ersten Oberfläche abgewandte zweite Oberfläche und ein Aufnahmeloch aufweist, wobei die zwei Seiten des Hauptkörpers jeweils mit einem Durchgangsloch versehen sind, wobei die Durchgangslöcher mit dem Aufnahmeloch durchgängig verbunden sind; eine Desinfektionslampe, die auf der zweiten Oberfläche des Hauptkörpers angeordnet ist und eine Lichtemissionseinheit, eine Erfassungseinheit, eine Steuereinheit und eine Stromversorgungseinheit umfasst; und ein Befestigungsteil, das durch die Durchgangslöcher und das Aufnahmeloch des Hauptkörpers hindurchgeführt ist.</p></li>
</ul>
<img alt="embedded image" id="EMI-D00000"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=DE326402481">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295937">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DEEP LEARNING BASED SYSTEM FOR DETECTION OF COVID-19 DISEASE OF PATIENT AT INFECTION RISK</strong> - The present invention relates to Deep learning based system for detection of covid-19 disease of patient at infection risk. The objective of the present invention is to solve the problems in the prior art related to technologies of detection of covid-19 disease using CT scan image processing. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN324122821">link</a></p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can Biden Reverse Trump’s Damage to the State Department?</strong> - Reeling from the leadership of Rex Tillerson and Mike Pompeo, career officials wonder whether Secretary of State Antony Blinken can revitalize American diplomacy. - <a href="https://www.newyorker.com/books/page-turner/can-biden-reverse-trumps-damage-to-the-state-department">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Iran Moves Toward a One-Party State</strong> - The Supreme Leader is willing to risk the legitimacy of an election to consolidate monolithic hard-line control. - <a href="https://www.newyorker.com/news/our-columnists/iran-moves-toward-a-one-party-state">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The High Cost of Biden’s Meeting with Putin</strong> - To Biden, illusions are a hazard in foreign policy; to Putin, they are its currency. - <a href="https://www.newyorker.com/news/our-columnists/the-high-cost-of-bidens-meeting-with-putin">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How a Conservative Activist Invented the Conflict Over Critical Race Theory</strong> - To Christopher Rufo, a term for a school of legal scholarship looked like “the perfect weapon.” - <a href="https://www.newyorker.com/news/annals-of-inquiry/how-a-conservative-activist-invented-the-conflict-over-critical-race-theory">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Joe Biden Just Had a Summit with Vladimir Putin and Nothing Crazy Happened</strong> - The triumph of Geneva is that it was not Helsinki. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/joe-biden-just-had-a-summit-with-vladimir-putin-and-nothing-crazy-happened">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
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<li><strong>Chimamanda Ngozi Adichie’s cancel culture screed is a dangerous distraction</strong> -
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<img alt="Chimamanda Ngozi Adichie attends Paris Fashion Week 2020. " src="https://cdn.vox-cdn.com/thumbor/bUclV2lgwseFBhCKm--WBRL8xEU=/314x200:2281x1675/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69471504/1200754155.0.jpg"/>
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Other prominent writers have accused Chimamanda Ngozi Adichie of transphobia. | Francois Durand/Getty Images for Dior
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
We’re having the wrong conversation.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PuPjc4">
One of the worst aspects of any cancel culture debate is the tendency to obscure, deny, and dismiss as invalid any actual harm caused by whatever sparked the debate. Frequently, this cycle is tied to transphobia: Prominent public figures who’ve been criticized for making transphobic statements have frequently mounted angry backlashes against “cancel culture” as a way of denigrating their critics.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CMc9oS">
The latest person to fall into this pattern is the well-known feminist author Chimamanda Ngozi Adichie.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8ZGcmj">
Earlier this week, Adichie published a lengthy and eloquent takedown of cancel culture on her personal website. In <a href="https://www.chimamanda.com/news_items/it-is-obscene-a-true-reflection-in-three-parts/">the essay</a>, which has an estimated reading time of 16 minutes, she personally discusses two former students of hers, people who she feels have personally attacked and maligned her as a transphobe.
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Though Adichie does not name either of the two former students, one of them <a href="https://thecorrespondent.com/810/naming-is-a-tool-of-power/107226949500-916fc9b7">appears to be</a> Nigerian writer and queer activist OluTimehin Adegbeye. The other <a href="https://www.theguardian.com/books/2021/jun/16/chimamanda-ngozi-adichie-social-media-sanctimony">appears to be</a> writer (and Vox Book Club selected author) <a href="https://www.vox.com/culture/22423435/akwaeke-emezi-interview-death-of-vivek-oji">Akwaeke Emezi</a>, who is nonbinary. Both have spent the past several years criticizing a series of Adichie’s public statements that have seemed to increasingly embrace transphobic ideology and language — a framing Adichie claims is false.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fUUFX8">
Since 2017, Adichie has drawn criticism from trans activists for seeming to embrace rhetoric championed by <a href="https://www.vox.com/identities/2019/9/5/20840101/terfs-radical-feminists-gender-critical">trans-exclusionary radical feminists (TERFs)</a>, who argue that trans women are not women — and for dismissing her critics when called out. Adichie doesn’t really confront this history in her essay. Instead, she characterizes the two former students as manipulative, and accuses them of using progressive social justice rhetoric to mask motivations that are, respectively, “calculating and insincere,” and “seeking attention and publicity to benefit themselves.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XeDo6Y">
It’s not precisely clear what prompted Adichie’s essay, though many observers have questioned her motives in choosing to publish it during <a href="https://www.vox.com/the-goods/22463879/kink-at-pride-discourse-lgbtq">Pride Month</a>. That timing, along with the letter’s tone, has made Adichie’s post come off as a direct attack against the individual students the essay refers to, even if she does not name them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0tbtZs">
Notably, the essay glosses over and decontextualizes criticisms the two former students have made against her, in order to claim that their statements were both personal and “violent.” For example, without directly quoting anyone, Adichie writes that one of the students in question “asked followers to pick up machetes and attack me” — an apparent reference to a January Twitter thread in which Emezi <a href="https://twitter.com/azemezi/status/1346268453221658624">wrote</a>: “I trust that there are other people who will pick up machetes to protect us from the harm transphobes like Adichie &amp; [J.K.] Rowling seek to perpetuate. I, however, will be in my garden with butterflies, trying to figure out how to befriend the neighborhood crows.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RNy6PS">
Adichie devotes the final third of her essay to condemning a polarized social media climate, essentially lashing out against <a href="https://www.vox.com/22384308/cancel-culture-free-speech-accountability-debate">cancel culture</a>, which she describes as “obscene.” She writes:
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There are many social-media-savvy people who are choking on sanctimony and lacking in compassion. … People who wield the words ‘violence’ and ‘weaponize’ like tarnished pitchforks. …
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I have spoken to young people who tell me they are terrified to tweet anything, that they read and re-read their tweets because they fear they will be attacked by their own. The assumption of good faith is dead. What matters is not goodness but the appearance of goodness. We are no longer human beings. We are now angels jostling to out-angel one another. God help us.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZrGokI">
Across social media, this finale to Adichie’s essay has been greeted by many with praise and glee. Though others have expressed reservations because of her attitude toward cancel culture and her minimization of her own words, much of the reception has indeed been positive. The public loves a good takedown, and hers is one of the most savage we’ve had in a while.
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It’s also the most pernicious.
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In a rush to praise the most quotable parts of Adichie’s cutting essay, many on the left have joined notorious transphobes, TERFs, and their allies, including signatories of the infamous 2020 <a href="https://www.vox.com/policy-and-politics/2020/7/22/21325942/free-speech-harpers-letter-bari-weiss-andrew-sullivan">Harper’s open letter</a> against the concept of cancel culture.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QYC43b">
As with that letter, which was signed by several figures who had publicly <a href="https://www.themarysue.com/harpers-mag-open-letter-dog-whistles/">expressed transphobic views</a>, transphobia has inevitably attached to the conversation around Adichie’s essay. On Twitter, those who say they are boycotting Adichie in response to learning of her transphobia are <a href="https://twitter.com/BlackQueerBC/status/1404913466381570049/retweets/with_comments">being harassed</a>. Adegbeye has locked her Twitter account; Emezi’s has been flooded with detractors.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2N1Fm2">
Worst of all, a conversation that should have been about transgender identity has been reframed. Now it’s about how “<a href="https://twitter.com/dhincha/status/1405200091523162121">difference of opinion doesn’t mean hatred</a>” and how <a href="https://twitter.com/thomaschattwill/status/1405172793780604929">social media “amplifies pathological and anti-social tendencies.”</a> Adichie’s essay minimizes and obscures her original actions and speech, and fans of the essay have joined her in that effort. They’re helping to further discredit Adegbeye and Emezi and the message they’ve been trying to amplify.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="U71EIv">
We’re having the wrong conversation — not the one about cancel culture, but the one about whether one of the most famous feminists in the world is actually transphobic, and what it means for trans women if she is.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ljsPxW">
Looking at the history of Adichie’s run-ins with the trans community, it’s clear that Adichie, not her critics, placed herself in this position, and that like many people who’ve faced similar callouts by vulnerable communities, she’s now calling out “cancel culture” as a tool of misdirection.
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Adichie’s public clashes with trans women and their allies date back to 2017
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Kw7MOL">
Adichie shot onto the global stage in 2006 with the publication of her acclaimed novel <em>Half a Yellow Sun</em>. Since then, she’s been a prominent author and an even more prominent feminist. In 2014, her viral TED talk (which was later published as a book) <em>We Should All Be Feminists</em> drew raves and wound up sampled in Beyonce’s song “<a href="https://www.vox.com/2014/8/28/18010546/beyonce-political-views">Flawless</a>.” Suffice to say, she’s not just <em>a</em> feminist — she’s a prominent feminist voice and, for many people, a crucial entry point to the entire concept of feminism.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CQHlaY">
In 2017, Adichie sat for an <a href="https://www.channel4.com/news/chimamanda-ngozi-adichie-on-feminism">interview</a> where she explained feminism for Britain’s Channel 4 News. In it, <a href="https://www.vox.com/identities/2017/3/15/14910900/chimamanda-ngozi-adichie-transgender-women-comments-apology">she responded</a> to the question, “If you’re a trans woman who grew up as a man … does that take away from becoming a woman — are you any less of a real woman?” (For the purposes of this argument, let’s set aside the issue with asking this question of a cisgender woman who has no idea what the experience of being a trans woman is like.)
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Adichie answered:
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mqySBb">
When people talk about, “Are trans women women?” my feeling is trans women are trans women. But I think if you’ve lived in the world as a man, with the privileges the world accords a man, and then sort of change — switch gender, it’s difficult for me to accept that then we can equate your experience with the experience of a woman who has lived from the beginning in the world as a woman and who has not been accorded those privileges that men are.
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I don’t think it’s a good thing to conflate everything into one. I don’t think it’s a good thing to talk about women’s issues being exactly the same as the issues of trans women. What I’m saying is that gender is not biology. Gender is sociology.
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</blockquote>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JQW8ah">
Adichie’s point that trans women have very different experiences than cisgender women is well-made and very important. Trans women experience higher rates of <a href="https://www.nsvrc.org/sites/default/files/publications/2019-02/Transgender_infographic_508_0.pdf">sexual assault and domestic violence</a>, <a href="https://endhomelessness.org/resource/transgender-homeless-adults-unsheltered-homelessness-what-the-data-tell-us/">homelessness</a>, <a href="https://pediatrics.aappublications.org/content/144/5/e20191183">suicide, and suicide attempts</a> than cisgender women, and they’re more likely to be <a href="https://scholarworks.gsu.edu/cgi/viewcontent.cgi?article=1060&amp;context=ssw_facpub">re-victimized</a> when they seek support. Further, Adichie’s insistence that gender is tied to sociology, not biology, is a crucial distinction in the debate over trans rights — one <a href="https://www.scientificamerican.com/article/sex-redefined-the-idea-of-2-sexes-is-overly-simplistic1/">backed by science</a>.
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But Adichie’s response also felt alarmingly aligned with the rhetoric of TERFism. People who buy into TERFism <a href="https://www.mediamatters.org/sexual-harassment-sexual-assault/comprehensive-guide-debunked-bathroom-predator-myth">explicitly paint</a> trans women as manipulative straight cisgender men, sexual predators just using a fake identity as “trans women” to get close to cisgender women in order to assault them. <a href="https://www.vox.com/identities/2019/12/19/21029874/jk-rowling-transgender-tweet-terf">Millions</a> of people subscribe to strains of this dangerous belief, including prominent public figures like Harry Potter creator <a href="https://www.vox.com/culture/21285396/jk-rowling-transphobic-backlash-harry-potter">J.K. Rowling</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="V95H88">
Adichie’s statements shared a number of commonalities with TERFism, starting with the idea that trans women “change — switch gender,” inaccurate phrasing which seems to discount gender dysphoria and the feeling of gender-centered disconnect between one’s brain and one’s body that many trans people experience throughout their lives.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hzEzQE">
Her depiction of trans women as being born with substantial amounts of male privilege also hewed uncomfortably close to the TERF argument that trans women don’t lose male privilege if they transition. As the transgender actress Laverne Cox has said, “the binary narrative, which suggests that all trans women transition from male privilege, erases a lot of experiences.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lcp7tn">
Most especially, Adichie’s refusal to say the oft-uttered words, <a href="https://www.hrc.org/resources/5-things-to-know-to-make-your-feminism-trans-inclusive">“trans women are women,”</a> and instead insist that “trans women are <em>trans</em> women” is a phrase that can easily stand in for a denial of trans identity. As Emily Crockett <a href="https://www.vox.com/identities/2017/3/15/14910900/chimamanda-ngozi-adichie-transgender-women-comments-apology">explained for Vox</a> in 2017, “when trans advocates and allies say that ‘trans women are women, they’re not actually trying to say that transgender women are the same as cisgender women (women who aren’t transgender). They’re trying to say that these differences shouldn’t disqualify trans women from the broader category of ‘womanhood.’”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ke3Ztv">
Adichie’s original comments in the interview regarding her wariness about “conflating women’s issues” with “trans women’s issues” made it difficult to tell whether she believes trans women do belong to that broader category of womanhood. Consequently, when trans activists heard Adichie use phrases as loaded as these, they were immediately on alert. Adichie later responded in <a href="https://www.facebook.com/chimamandaadichie/photos/a.469824145943.278768.40389960943/10154893542340944/?type=3&amp;theater">a Facebook post</a> in which she apologized and called her critics “valid” but also doubled down on much of her rhetoric about male privilege and inherent differences between cisgender women and trans women.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BTZGTN">
If Adichie had stopped speaking about this issue, the moment might have retained its ambiguity and lack of clarity — though it’s worth noting that, a year later, she seemed to dismiss the entire debate as “<a href="https://www.okayafrica.com/a-controversy-followed-chimamanda-ngozi-adichie-to-abantu-book-fest/">trans noise</a>.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZABFtM">
In 2020, Adichie spoke out again, this time in defense of <a href="https://www.vox.com/culture/21285396/jk-rowling-transphobic-backlash-harry-potter">a transphobic manifesto published by J.K. Rowling</a>, and her new comments framed her earlier ones in a much different light.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8vZ9or">
Rowling’s piece is rife with overt expressions of harmful TERF ideology, depicting trans teens as being merely influenced by Tumblr culture rather than experiencing actual dysphoria, and tying gender to biology despite clear scientific consensus to the contrary. Instead of acknowledging the<a href="https://ovc.ojp.gov/sites/g/files/xyckuh226/files/pubs/forge/sexual_numbers.html"> 50 percent of trans people</a> who experience sexual abuse or assault, Rowling uses her own status as a survivor of domestic violence to explain why she’s so afraid that trans women might be a threat to cisgender women, loudly expressing fear of what might happen “when you throw open the doors of bathrooms and changing rooms to any man who believes or feels he’s a woman.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="awATd7">
From start to finish, it is textbook transphobia, published by a woman with incredible cultural influence.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5uN8PD">
In November 2020 — during<a href="https://www.glaad.org/transweek"> Transgender Awareness Week</a> — the Guardian published<a href="https://www.theguardian.com/books/2020/nov/14/chimamanda-ngozi-adichie-america-under-trump-felt-like-a-personal-loss"> an interview</a> with Adichie in which she articulated her dislike of cancel culture. Then, out of nowhere, she offered a defense of Rowling’s “perfectly reasonable” piece, calling her “a woman who is progressive, who clearly stands for and believes in diversity,” and decrying the social media outrage against her as “cruel and sad.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="aCVR1e">
To date, the reaction to Rowling’s manifesto remains one of the clearest examples of a pattern that Adichie’s essay now upholds. From the moment Rowling published her manifesto, much of the conversation around it centered on how left-wing zealots wanted to “cancel” a beloved children’s author — with the result being that the cancel culture backlash frequently obscured the harm at the center of a transphobic argument.
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Condemning cancel culture has become a reliable way to obscure transphobia. That has real, harmful consequences for trans people.
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The public support of Rowling’s contemporaries — figures like Adichie and the 58 British public figures who defended Rowling in <a href="https://twitter.com/thesundaytimes/status/1310509608713302017">an open letter</a> last fall — furthers the narrative that anyone who’s upset is just an angry social justice warrior. Meanwhile, trans and nonbinary people like me are left smarting from the damaging impact of her words, which empower other public figures to promote a toxic, deeply regressive argument that denies trans women their humanity.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LiLIi0">
The idea that Adichie, with all her understanding of the struggles that trans people face, could read Rowling’s words and frame them as part of a “progressive worldview” is maybe the gaslight of all gaslights. I cannot see it as anything but a full embrace of TERFism.
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I also find it impossible to interpret her new essay as anything but another iteration of a pattern in which railing against cancel culture becomes a tool to dismiss legitimate arguments about the hateful thing you said and did.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="A1rwQN">
This conversation should be about trans identity. It should be about how awful it is for trans and nonbinary people to see beloved figures like Rowling and Adichie promoting an ideology that insists we’re not really the gender we say we are, that we’re liars and sexual predators, that we’re chasing a social media fad and performing wokeness for leftist clout, that we’re making it all up. It should be about figuring out why women with so much education and so much initial empathy wind up adopting a belief system so dedicated to othering people who are already vulnerable and at-risk.
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It should be about how political debates about trans identity negatively impact the mental health of <a href="https://www.thetrevorproject.org/survey-2021/">94 percent of trans teens</a>. It should be about the damage that is done when respected public figures like Adichie and Rowling use their massive influence to air transphobic views under the guise of “perfectly reasonable” debate about whether trans women are women.
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It should not be about what a sick burn Adichie delivered.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DrF3kW">
It is not difficult to write a takedown of cancel culture, or to explain why it’s so painful to be denied a good-faith conversation with people you have a personal relationship with. (Though according to the essay, Adichie apparently disliked and distrusted her two former students from the outset.)
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It takes much more courage to grapple with the reason they denied you that interaction. That’s what Adichie should be doing now, instead of extending the pain she caused others to many more of her trans readers.
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Adichie’s essay is a distraction. She should not, now, get to own the conversation about the harmful impact of her words and actions.
</p></li>
<li><strong>What tennis pros look at when they choose a ball</strong> -
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/ddBD4zDArCEhRTb7-fy2ZrknWpI=/240x0:1680x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69471324/TennisThumb_Clean.0.png"/>
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It all comes down to fluff.
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Before each serve, most professional tennis players go through a ritual to get in the zone. Novak Djokovic will bounce the ball with his racket, then with his hand. Rafael Nadal will usually pull at his shorts and the sleeves around his shoulders, then touch his nose and tuck his hair behind his ears. Each has a very distinctive routine. But there’s one tennis ritual nearly every pro tennis player does: choosing a specific tennis ball. A common belief among players is that the ball they choose can help them win.
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But there’s real physics at play behind this ritual — and It all comes down to the fuzz. For a faster serve, players try to find a compact ball. For a slower serve, they feel for more fuzz. The idea is that a fluffier ball is more likely to be slowed by drag as it travels through the air — and that choosing the right level of fuzz can help the serving player defeat their opponent.
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You can find this video and all of <a href="https://www.youtube.com/channel/UCLXo7UDZvByw2ixzpQCufnA">Vox’s videos on YouTube</a>. And if you’re interested in supporting our video journalism, you can <a href="https://www.vox.com/join">become a member of the Vox Video Lab on YouTube</a>.
</p></li>
<li><strong>US investment alone won’t solve Central America’s migrant crisis</strong> -
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/yAMYML10dNDgMW0WpH52BN67YeY=/267x0:4267x3000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69471378/1233232172.0.jpg"/>
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US Vice President Kamala Harris answers a question about her upcoming trip to Guatemala and Mexico in Washington, DC on June 2. | Mandel Ngan/AFP/Getty Images
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Kamala Harris wants big US companies to invest in Central America.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jSqg21">
A key prong of the Biden administration’s plan to address the root causes of migration from Central America is to bring more foreign investment to the region, to improve economic opportunities and give people a reason to stay.
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Vice President Kamala Harris recently announced a partnership with 12 private-sector companies and organizations to support “<a href="https://www.whitehouse.gov/briefing-room/statements-releases/2021/05/27/fact-sheet-vice-president-harris-launches-a-call-to-action-to-the-private-sector-to-deepen-investment-in-the-northern-triangle/">inclusive economic development</a>” in the Northern Triangle of Central America, which includes Guatemala, Honduras, and El Salvador. US government agencies, including the State Department, will also work with governments in the region to remove impediments to international investment and foster new private-sector partnerships.
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Among the commitments, Mastercard is supporting 1 million small businesses in the region; Chobani is creating a startup incubator for food entrepreneurs in Guatemala; Microsoft is expanding broadband access to up to 3 million people by next July; and Nespresso is starting to source coffee from El Salvador and Honduras and expanding its existing operations in Guatemala with a minimum $150 million investment by 2025.
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Though the lack of foreign investment is far from the only factor driving people to make the journey north, the idea is that improving economic conditions will contribute to overall stability in the region, which has long suffered from persistent corruption, weak government institutions, and high levels of violent crime.
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“The benefit of this effort will probably not evidence itself overnight, but will be well worth it,” Harris <a href="https://www.npr.org/2021/05/27/1001026383/harris-issues-a-call-to-action-to-invest-in-central-america">said</a> of the initiative. “We do understand our work is in the context of long-standing and deep-rooted factors.”
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But experts say there’s a long way to go in persuading would-be migrants that the economic opportunities at home are better than what they might find in the US.
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“The amount of money that needs to be going into these countries to really begin to make a dent in matters of employment — in allowing people to make salaries to fulfill their basic needs — is far bigger than we have seen in any recent time,” said Oscar Chacon, executive director of Alianza Americas, a network of Latin American and Caribbean immigrant organizations in the United States.
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Currently, an average of <a href="https://www.statista.com/statistics/1037216/informal-employment-share-latin-america-caribbean-country/">about 76 percent of workers among the three Northern Triangle countries</a> have informal, often low-paying jobs — as street vendors, domestic workers, farm workers, and in service industries — without a fixed monthly salary or benefits. They typically do not pay taxes, meaning that they cannot access government pensions or credit from financial institutions, and are often working in poor conditions with little job security or assurance that they can meet their families’ basic needs.
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What’s more, direct foreign investment in the region has been minimal in recent decades. In 2019, the last year for which there is available data, foreign investment to El Salvador, Honduras and Guatemala was just under <a href="https://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en">$2.2 billion</a> combined, according to data from the United Nations Conference on Trade and Development. By comparison, migrants who left those countries sent a total of<a href="https://unctadstat.unctad.org/wds/ReportFolders/reportFolders.aspx?sCS_ChosenLang=en"> $22 billion in remittances</a> back home that year.
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<img alt=" " src="https://cdn.vox-cdn.com/thumbor/z-IRPmaIvevqsXhB_-nfDZ6B0xM=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22663376/EoQz9_weak_foreign_investment_in_the_northern_triangle.png"/> <cite>Nicole Narea/Vox</cite>
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That suggests that the levels of foreign investment required to change the calculus around people’s decisions to migrate is much larger than what the region has received in the past. Harris’s initiative, therefore, only represents a starting point.
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And experts say it should be coupled with other measures to improve the quality of life in the Northern Triangle and not come at the expense of partnerships with local organizations that might have a better sense of how to effectively put US dollars to use than large, multinational companies.
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The US needs to help Northern Triangle countries prepare their workforce for better opportunities
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Harris’s public-private partnership recognizes that immediately putting money in people’s pockets is the first step toward meaningfully improving quality of life in the Northern Triangle.
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For immigrant advocates and civil society groups working in the region, that understanding is a welcome shift from former President Donald Trump’s decision to <a href="https://www.cfr.org/backgrounder/central-americas-turbulent-northern-triangle">slash US aid</a> to the region by a third, as well as from the security-focused agenda of the Obama administration, which tied US aid to governments’ ability to crack down on crime and reduce homicide rates.
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But there’s a question of what happens if that money stops flowing in the long term — say, if the midterm elections in the US bring about changes in congressional leadership, or if there is a change in administration in 2024.
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A potentially more enduring solution is ensuring that the Northern Triangle’s workforce is prepared to attract more foreign investment and compete for higher-quality jobs in a global market. That can also help alleviate the structural inequality in these economies, which are <a href="https://www.atlanticcouncil.org/in-depth-research-reports/issue-brief/combatting-corruption-in-the-northern-triangle-prioritizing-a-whole-of-society-approach/">dominated by elites</a>, many of whom bribe politicians to enable their illicit and anticompetitive business practices.
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But such a transformation of the workforce might take well over a decade to achieve.
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“In order for Honduras, El Salvador, and Guatemala to really compete for good jobs, there is a bit of a homework that needs to be done in terms of preparing the actual workforce in these countries to be in a position to assimilate the possibility of a Microsoft or Google or any other technology company that wants to do heavy investments in these countries,” Chacon said.
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That means improving education — and not just formal education, but also vocational training that can set up students to fill niches sought out by international investors.
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“We still don’t have a level of education such that we can manufacture or assemble cars or computers,” said Lester Ramirez, the director of governance and transparency at the Association for a More Just Society, a civil society group based in Honduras. “That is something that we should be working on, if we want to be part of the global market.“
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It also involves more basic quality-of-life improvements, such as ensuring that workers are healthy and have access to medical care, and that there is rule of law.
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Costa Rica, which brought in <a href="https://www.state.gov/reports/2020-investment-climate-statements/costa-rica/">$2.5 billion</a> in direct foreign investment in 2019 — more than all of the Northern Triangle countries combined — can serve as a potential model in that respect. Unlike the Northern Triangle, it has invested in preparing a qualified workforce to be competitive, and not just for low-paying jobs, Chacon said.
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“Investors in Costa Rica are very confident that the rules are there solidly in place, that they have a very good system of checks and balances, and that there is hardly any corruption anybody can point to,” he said. “That is very different from Guatemala, Honduras, and El Salvador.”
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US companies can help curb corruption — so long as they don’t exploit workers
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There are pros and cons to bringing in big, multinational companies to invest in the Northern Triangle.
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They can help bring more people into the formal economy and will pay taxes, which can help support a social safety net that governments in the region have so far been unable to provide.
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That’s important because countries in the Northern Triangle have among the lowest effective tax rates in the world. Workers with informal jobs don’t typically pay taxes and local corporations often try to evade them, which has hampered governments’ ability to <a href="https://www.cfr.org/backgrounder/central-americas-turbulent-northern-triangle">provide social services</a>.
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Guatemala’s 2019 tax revenue, for instance, was just <a href="https://www.oecd-ilibrary.org/docserver/42696dbd-en-es.pdf?expires=1623779575&amp;id=id&amp;accname=guest&amp;checksum=1679863E930A79C77BD163FB6791C00D">13.1 percent</a> of its GDP — the lowest among Latin America and Caribbean countries, which by comparison brought in nearly 23 percent of their GDP on average.
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“The private sector in Central America has demonstrated decade after decade that it really is unwilling to pay higher taxes to reinvest in the human capital of the people of Central America,” said Paul Angelo, a fellow for Latin America studies at the Council on Foreign Relations.
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While US companies might also try to get out of paying their fair share of taxes, they are still better than their Central American counterparts in that respect.
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What’s more, American companies can serve as a more reliable partner for the Biden administration than government actors in the region who have perpetuated the problems that are driving people to flee.
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Juan Orlando Hernández, the president of Honduras, has been named as a co-conspirator in his brother’s drug crimes by US prosecutors and remains under investigation by the Department of Justice. Nayib Bukele, the president of El Salvador, has earned a reputation as a “<a href="https://www.latimes.com/world-nation/story/2021-05-16/nayib-bukele-the-most-popular-president-in-the-world-is-a-man-with-one-ideology-power">millennial dictator</a>” for strong-arm tactics such as sending troops to pressure lawmakers to approve anti-crime funding and ousting his critics in the country’s Supreme Court and attorney general’s office.
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“In the Northern Triangle countries, we don’t really have any democratically-minded or reform-minded [government] partners,” Angelo said. “And so I think it’s only natural that the US government would seek to partner with the private sector, and particularly with American companies that we know generally abide by the rule of law.”
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But the influence of US corporations in the region hasn’t been all positive in the past. They have engaged in their own kind of <a href="https://www.thenation.com/article/archive/what-free-trade-has-done-central-america/">exploitative business practices</a>: for example, preventing workplaces from unionizing by simply taking their business to another country in the region to assure themselves cheap labor, Chacon said.
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He added that the US government has historically ignored these practices and allowed American companies to perpetuate “voracious capitalism.” The Biden administration can’t allow international companies to repeat those mistakes. Just as the Biden administration is turning attention to worker rights in the US, it should do the same in Central America, Chacon said.
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And some say the administration should focus its efforts primarily on coordinating with local civil society groups, who better understand the challenges on the ground than any large multinational corporation or organization or even US government agency. Harris has prioritized meeting with such groups early on — particularly in Guatemala, which has the most developed civil society of the three countries — but advocates from the region want to see even more collaboration.
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Civil society groups in the Northern Triangle are “much more committed to see that the projects are successful,” Chacon said. “The US would do much better by not only investing more, but investing in a truly new set of partners, both in the rural areas as well as in the cities.”
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</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Milkha Singh battles “rough day”, oxygen saturation level dips</strong> - The 91-year-old, who tested negative for COVID-19 on Wednesday, is being closely monitored by a team of doctors.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Ravindra Jadeja takes care of his mental health</strong> - From dealing with criticism to battling injuries, Ravindra Jadeja talks about everything cricket and how he keeps mental health in check</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>World Test Championship final: First session rained out</strong> - The match was scheduled to start at 3pm (IST) but the weather ensured that the pitch at the Ageas Bowl was covered and the toss was delayed.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ten debutants in Indian men’s hockey squad for Tokyo Olympics</strong> - India on Friday name 10 Olympic debutants in its 16-member men’s hockey squad, which also features seasoned performers like PR Sreejesh and Manpreet</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Vukomanovic takes charge of Blasters</strong> - The Serb has coached top clubs in Belgium, Slovakia and Cyprus</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Malnad areas receive heavy rains</strong> - The south-west monsoon has been active in the Malnad areas of the district. Many parts of Shivamogga, Chikkamagaluru, and Hassan district received hea</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Data | Centre’s tax revenues grew despite stringent lockdown on the back of excise duties</strong> - Shift in tax burden comes at a time when pandemic has led to many job losses and reduced income levels</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kasturba Hospital in Manipal to resume all medical services from June 21</strong> - COVID-19 test (RT-PCR) is mandatory for in-patient admission for surgical services</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Doctors stage protest against attacks on healthcare professionals</strong> - They raise slogans and urge people to support their cause</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Fr. Muller Medical College Hospital to begin COVID-19 vaccination from June 21</strong> - Covishield will be administered at a price of ₹750 per dose</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Greece killing: Husband confesses to Caroline Crouch death</strong> - Police say a Greek pilot has admitted suffocating his wife in a crime that shocked the country.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Far-right abuse: Racism case seen as threat to whole German army</strong> - Germany’s defence minister condemns a platoon accused of sexual abuse and singing racist songs.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Alarming Covid surge cools Russia’s football fever</strong> - Despite being one of the first countries to develop a jab, Covid cases are sharply rising in Russia.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Alieu Kosiah: Liberian convicted of war crimes in Swiss court</strong> - Alieu Kosiah is the first Liberian to be convicted for acts committed during the country’s civil war.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UK food and drink exports to the EU almost halve in first quarter</strong> - The pandemic and Brexit hit exports in the first three months of the year, says the Food and Drink Federation.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Arcade1Up pinball cabinet review: Fine for families, interesting for modders</strong> - The default package is worth its $600 cost, but do your research before buying. - <a href="https://arstechnica.com/?p=1774443">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apple and Google’s AI wizardry promises privacy—at a cost</strong> - Upgraded data protection and less reliance on the cloud could lock users in. - <a href="https://arstechnica.com/?p=1774415">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rocket Report: China launches crew mission, SpaceX runs into road troubles</strong> - “The Space Safari team intends to push the envelope.” - <a href="https://arstechnica.com/?p=1774379">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine arrests ransomware gang in global cybercriminal crackdown</strong> - Arrests of Cl0p hacker group members adds to pressure on other countries to follow suit. - <a href="https://arstechnica.com/?p=1774423">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Game Boy Advance game gets split-screen multiplayer through new FPGA core</strong> - No link-cable needed for this emulated single-machine, single-display solution. - <a href="https://arstechnica.com/?p=1774517">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A wealthy, but stingy father was trying to put a birthday party together for his 18 y/o daughter.</strong> - <!-- SC_OFF -->
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He wanted the party to be extravagant, but wanted to spend as little money as possible. He had finished all of the other decorations, and he was left to work on the cake.
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“Why not get it ordered from an upscale bakery?” his wife said.
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So the father visited a ton of different bakeries and did research, but found the prices to be too high.
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My daughter is inviting all of her friends, and I’ll look bad if I don’t put together a good cake, he thought. Then, he stumbled upon a shop that opened once a year to provide free cake to its customers.
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How quaint, the father thought, but desperate, he walked inside to see if they could provide a cake for his daughter’s birthday.
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He was met by a Buddhist monk chanting and lighting incense.
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“Hello,” the father asked, “I would like to buy a cake.”
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“Of course,” the monk replied, “just draw a picture of the cake you would like on the notepad on the desk.”
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The father thought this to be weird, but wanting to save as much money as possible, he gave him the address and told him to come in the backdoor, just in case the cake was bad.
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The day of the party arrived and the monk visited the house with the most extravagant cake the family had ever seen. All of the guests were in awe, and whispered to each other about how much the cake could have cost.
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The monk became the guest of honor and at the end of the party, the father approached the monk and asked,
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“Why do you do this for free? You should take money for your services!”
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The monk smiled and said, “I do this for free because a cake day is the best way to earn karma.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/albene"> /u/albene </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o2e0np/a_wealthy_but_stingy_father_was_trying_to_put_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o2e0np/a_wealthy_but_stingy_father_was_trying_to_put_a/">[comments]</a></span></p></li>
<li><strong>An 80 year old man finds a talking frog</strong> - <!-- SC_OFF -->
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An 80 year old man is out by a pond one day when a frog jumps onto a lily pad nearby.
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“Excuse me sir,” says the frog, “I know I may appear to be just a frog, but I’m actually a beautiful princess. A witch has placed a curse on me to keep me in this form. The only thing that can break this curse is a kiss. Sir, if you kiss me and break this curse, I’ll turn back into a beautiful princess and I’ll make love to you all day and night. So what do you say?”
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The 80 year old man thinks for moment then picks up the frog and puts it in his pocket and continues on his walk.
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“Didn’t you hear me?”, says the frog, “I said if you kiss me I’ll turn back into a beautiful princess and make love to you all day and night.”
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“Eh”, says the man, “I’m 80 years old. At this point I think I’d rather have a talking frog.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/hazardadams"> /u/hazardadams </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o2ae87/an_80_year_old_man_finds_a_talking_frog/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o2ae87/an_80_year_old_man_finds_a_talking_frog/">[comments]</a></span></p></li>
<li><strong>I accidentally sprayed deodorant in my mouth today…</strong> - <!-- SC_OFF -->
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Now when I talk I have this weird axe scent
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/TheGertruder"> /u/TheGertruder </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o21p08/i_accidentally_sprayed_deodorant_in_my_mouth_today/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o21p08/i_accidentally_sprayed_deodorant_in_my_mouth_today/">[comments]</a></span></p></li>
<li><strong>Communist jokes aren’t funny</strong> - <!-- SC_OFF -->
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Unless everyone gets them.
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My favorite joke for my cake day
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/treatfriday"> /u/treatfriday </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o2cgo0/communist_jokes_arent_funny/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o2cgo0/communist_jokes_arent_funny/">[comments]</a></span></p></li>
<li><strong>I’ve recently became a father, so for the past few weeks I thought I’d try my hand at telling dad jokes.</strong> - <!-- SC_OFF -->
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He says I should go home and support my wife.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Got-a-PhD-in-THC"> /u/Got-a-PhD-in-THC </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/o2coaa/ive_recently_became_a_father_so_for_the_past_few/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/o2coaa/ive_recently_became_a_father_so_for_the_past_few/">[comments]</a></span></p></li>
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