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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Coping with ‘Lockdown Babies’: Understanding Postpartum Maternal Experience in London, UK</strong> -
<div>
The postpartum/postnatal period is a time where mothers require greater levels of support from multiple formal and informal sources. However, stay-at-home orders commonly known as “lockdown” deployed in some countries to limit COVID-19 transmission likely led to reduced availability of support, which may have implications for maternal wellbeing. In-depth understanding of maternal experience during this period of heightened collective stress may reveal factors which are crucial for maternal wellbeing, which in turn can help services and policy makers prioritise, protect, or address these areas. Here we conduct an online focus group study involving 20 mothers living in London, England, with “lockdown babies,” following up on our earlier survey on social support and maternal wellbeing. We conduct thematic analysis of focus group transcripts, and identify several key themes around Lockdown Experience and Determinants of Lockdown Experience. Participants raised some positives of lockdown, including fostering connections and protection from external expectations, but also raised many negatives, including social isolation, institutional abandonment, and intense relationships within the household. Potential reasons behind variations in lockdown experience include physical environments, timing of birth, and parity. Our results reveal complex experiences of the first national lockdown, both positive and negative. We discuss potential implications for post-lockdown policy and practice to promote postpartum wellbeing, such as facilitating partners to stay at home, and addressing the culture of “maternal surveillance” and “parenting experts.”
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/r7enw/" target="_blank">Coping with ‘Lockdown Babies’: Understanding Postpartum Maternal Experience in London, UK</a>
</div></li>
<li><strong>Social factors and UFO reports: was the SARS-CoV-2 pandemic associated with an increase in UFO reporting?</strong> -
<div>
The ongoing SARS-Cov-2 pandemic had many drastic effects upon society beyond the illness and death it caused. Pandemic mitigation measures disrupted and altered behaviors related to social mobility, significantly increasing the time spent at home compared to the pre-pandemic period. Further, it was well documented that social anxiety and stress increased at a population level. Early in the pandemic there was speculation in the popular media that reporting of paranormal phenomena (e.g., UFOs, ghosts, etc.) increased due to factors associated with the pandemic. Past research on UFO/UAP reporting has theorized that increases are triggered by social factors, and so the pandemic provided a natural experiment to test these claims. To measure UFO reports we utilized two public databases of UFO reports for sightings in the United States, provided by the National UFO Reporting Center and the Mutual UFO Network. To estimate the impact of the pandemic we utilized two measures, one for social mobility and one for pandemic/disease severity. Google Community Mobility Reports provided a metric of social mobility for people who use Google Maps on their cellular telephone (i.e., amount of time spent at work compared to home), which we aggregated to a state level to estimate time spent at home. Second, we used new weekly SARS-CoV-2 cases and deaths, both absolute counts and per capita, which can be considered to be an indirect measure of anxiety and stress. We find that UFO reports did increase in 2020 compared to 2019 (p&lt;0.001 for both databases); however, the level of UFO reporting had little to no association with the various pandemic-related measures, offering no support for hypothesized social factors that influence reporting. A complicating factor in UFO reporting is the start in 2019 of Starlink satellite launches. These launches include up to 60 small satellites at once, and so are very distinctive and often easily visible. As a result, many people report these as UFOs. We coded and removed these reports from the sighting databases, and the filtered data similarly have no association with the pandemic-related factors. Further, with Starlink reports removed, there was no increase in sightings in 2020 compared to 2019. Our results contribute to an understanding of large-scale factors that impact the reporting of paranormal events, especially timely given the renewed public and government focus on the UFO phenomenon today.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/exm7c/" target="_blank">Social factors and UFO reports: was the SARS-CoV-2 pandemic associated with an increase in UFO reporting?</a>
</div></li>
<li><strong>Increasing SARS-CoV2 cases, hospitalizations and deaths among the vaccinated elderly populations during the Omicron (B.1.1.529) variant surge in UK.</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
BACKGROUND There were increased SARS-CoV2 hospitalizations and deaths noted during Omicron (B.1.1.529) variant surge in UK despite decreased cases, and the reasons are unclear. METHODS In this observational study, we analyzed reported SARS-CoV2 cases, hospitalizations and deaths during the COVID-19 pandemic in the UK. We also analyzed variables that can affect the outcomes. The vaccine effectiveness among those ≥18 years of age (August 16, 2021 to March 27, 2022) was analyzed. RESULTS Of the total cases (n= 22,072,550), hospitalizations (n=848,911) and deaths (n=175,070) due to COVID-19 in UK; 51.3% of cases (n=11,315,793), 28.8% of hospitalizations (n=244,708) and 16.4% of deaths (n=28,659) occurred during Omicron variant surge. When comparing the period of February 28-May 1, 2022 with the prior 12-weeks, we observed a significant increase in the case fatality rate (0.19% vs 0.41%; RR 2.11[ 2.06-2.16], p&lt;0.001) and odds of hospitalization (1.58% vs 3.72%; RR 2.36[2.34-2.38]; p&lt;0.001). During the same period a significant increase in cases (23.7% vs 40.3%; RR1.70 [1.70-1.71]; p&lt;0.001) among ≥50 years of age and hospitalizations (39.3% vs 50.3%;RR1.28 [1.27-1.30]; p&lt;0.001) and deaths (67.89% vs 80.07%;RR1.18 [1.16-1.20]; p&lt;0.001) among ≥75 years of age was observed. The vaccine effectiveness (VE) for the third dose was in negative since December 20, 2021, with a significantly increased proportion of SARS-CoV2 cases hospitalizations and deaths among the vaccinated; and a decreased proportion of cases, hospitalizations, and deaths among the unvaccinated. The pre-existing conditions were present in 95.6% of all COVID-19 deaths, various ethnic, deprivation score and vaccination rate disparities noted that can adversely affect hospitalization and deaths among compared groups. CONCLUSIONS There is no discernable vaccine effectiveness among ≥18 years of age, vaccinated third dose population since the beginning of the Omicron variant surge. Pre-existing conditions, ethnicity, deprivation score, and vaccination rate disparities data need to be adjusted for evaluating VE for hospitalizations and deaths. The increased cases with significantly increased hospitalizations and deaths among the elderly population during the Omicron variant surge underscores the need to prevent infections in the elderly irrespective of vaccination status with uniform screening protocols and protective measures.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.28.22276926v1" target="_blank">Increasing SARS-CoV2 cases, hospitalizations and deaths among the vaccinated elderly populations during the Omicron (B.1.1.529) variant surge in UK.</a>
</div></li>
<li><strong>Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice</strong> -
<div>
As the SARS-CoV-2 pandemic remains uncontrolled owing to the continuous emergence of variants of concern, there is an immediate need to implement the most effective antiviral treatment strategies, especially for risk groups. Here, we evaluated the therapeutic potency of nirmatrelvir, remdesivir, and molnupiravir and their combinations in SARS-CoV-2-infected K18-hACE2 transgenic mice. Systemic treatment of mice with each drug (20 mg/kg) resulted in slightly enhanced antiviral efficacy and yielded an increased life expectancy of only about 20-40% survival. However, combination therapy with nirmatrelvir (20 mg/kg) and molnupiravir (20 mg/kg) in lethally infected mice showed profound inhibition of SARS-CoV-2 replication in both the lung and brain and synergistically improved survival times up to 80% compared to those with nirmatrelvir (P= 0.0001) and molnupiravir (P= 0.0001) administered alone. This combination therapy effectively reduced clinical severity score, virus-induced tissue damage, and viral distribution compared to those in animals treated with these monotherapies. Furthermore, all these assessments associated with this combination were also significantly higher than that of mice receiving remdesivir monotherapy (P= 0.0001) and the nirmatrelvir (20 mg/kg) and remdesivir (20 mg/kg) combination (P= 0.0001), underscored the clinical significance of this combination. By contrast, the nirmatrelvir and remdesivir combination showed less antiviral efficacy, with lower survival compared to nirmatrelvir monotherapy, demonstrating the inefficient therapeutic effect of this combination. The combination therapy with nirmatrelvir and molnupiravir contributes to alleviated morbidity and mortality, which can serve as a basis for the design of clinical studies of this combination in the treatment of COVID-19 patients.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.27.497875v1" target="_blank">Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice</a>
</div></li>
<li><strong>The Staphylococcus aureus iron-regulated surface determinant A (IsdA) increases SARS CoV-2 replication by modulating JAK-STAT signaling</strong> -
<div>
The emergence and spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) and the associated Coronavirus disease (COVID-19) pandemic have affected millions globally. Like other respiratory viruses, a significant complication of COVID-19 infection is secondary bacterial co-infection, which is seen in approximately 25% of severe cases. The most common organism isolated from co-infection is the Gram-positive bacterium Staphylococcus aureus. Here, we developed an in vitro co-infection model where both CoV-2 and S. aureus replication kinetics can be examined. We demonstrate CoV-2 infection does not alter how S. aureus attaches to or grows in host epithelial cells. In contrast, the presence of replicating S. aureus enhances the replication of CoV-2 by 10-15-fold. We identify this pro-viral activity is due to the S. aureus iron-regulated surface determinant A (IsdA) and this effect is mimicked across different SARS CoV-2 permissive cell lines infected with multiple viral variants. Analysis of co-infected cells demonstrated an IsdA dependent modification of host transcription. Using chemical inhibition, we determined S. aureus IsdA modifies host Janus Kinase - Signal Transducer and Activator of Transcription (JAK-STAT) signalling, ultimately leading to increased viral replication. These findings provide key insight into the molecular interactions that occur between host cells, CoV-2 and S. aureus during co-infection.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.27.497883v1" target="_blank">The Staphylococcus aureus iron-regulated surface determinant A (IsdA) increases SARS CoV-2 replication by modulating JAK-STAT signaling</a>
</div></li>
<li><strong>Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2</strong> -
<div>
The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for pathogenesis and lethality. While small molecule inhibitors of Mac1 have great therapeutic potential, few have been described. Here, we report the structure-based development of several chemical scaffolds exhibiting low- to sub-micromolar affinity for Mac1 through iterations of computer-aided design, structural characterization by ultra-high resolution X-ray protein crystallography, and binding evaluation with in-solution assays. Potent scaffolds were designed with in silico linkage of previously obtained fragment hits and ultra-large library docking screens of more than 450 million molecules. In total, 160 hits comprising 119 different scaffolds were discovered and 152 Mac1-ligand complex crystal structures were determined, typically to 1 [A] resolution or better. The structure-activity-relationships emerging from this study may template future drug development against Mac1.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.27.497816v1" target="_blank">Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2</a>
</div></li>
<li><strong>Wastewater surveillance of influenza activity: Early detection, surveillance, and subtyping in city and neighbourhood communities</strong> -
<div>
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Recurrent epidemics of influenza infection and its pandemic potential present a significant risk to global population health. To mitigate hospitalizations and death, local public health relies on clinical surveillance to locate and monitor influenza-like illnesses and/or influenza cases and outbreaks. At an international level, the global integration of clinical surveillance networks is the only reliable method to report influenza types and subtypes and warn of an emergent pandemic strain. During the COVID-19 pandemic, the demonstrated utility of wastewater surveillance (WWS) in complementing or even replacing clinical surveillance, the latter a resource-intensive enterprise, was predicated on the presence of stable viral fragments in wastewater. We show that influenza virus targets are stable in wastewaters and partitions to the solids fraction. We subsequently quantify, type, and subtype influenza virus in municipal wastewater and primary sludge throughout the course of a community outbreak. This research demonstrates the feasibility of applying influenza virus WWS to city and neighbourhood levels; showing a 17-day lead time in forecasting a citywide flu outbreak and providing population-level viral subtyping in near real-time using minimal resources and infrastructure.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.28.22276884v1" target="_blank">Wastewater surveillance of influenza activity: Early detection, surveillance, and subtyping in city and neighbourhood communities</a>
</div></li>
<li><strong>Evaluating a novel, integrative dashboard for health professionals performance in managing deteriorating patients: quality improvement project</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The quality of recording and documentation of deteriorating patient management by health professionals has been challenged at health system level during the COVID-19 pandemic. Non-adherence to monitoring and escalation guidelines and poor documentation increases risk of serious adverse events. Electronic health record (EHR)-integrated dashboards are real-time auditing tools of patients status and clinicians performance, but neither the views nor the performance of health professionals have been assessed, relating to management of deteriorating patients . Objective: To develop and evaluate a real-time dashboard of deteriorating patients assessment, referral, and therapy by examining the perception of the dashboard and the performance of nurses and physicians. Settings: Five academic hospitals in the largest NHS trust in the UK (Barts Health NHS Trust). Intervention: The dashboard was developed from EHR data to investigate patients with NEWS2&gt;5, assessment, and escalation of deteriorating patients. We adopted the Plan, Do, Study, Act model and followed the SQUIRE framework to evaluate the dashboard. Design: Mixed methods: (i) Virtual, face-to-face, key informant interviews and (ii) Retrospective descriptive EHR data analysis to measure performance change over time. Results: We interviewed 3 nurses (2 quality and safety and 1 informatics specialists). Key themes were: (1) participants perceived the dashboard as a facilitator for auditing NEWS2 recording and escalation of care to improve clinicians practice; (2) There is a need for guiding clinicians and adjusting data sources and metrics which could enhance the functionality and usability. From EHR (2019 to 2022) data analysis showed: (1) NEWS2 recording has gradually improved in the implementation and evaluation phases (May 2021 to Apr 2022) from 64% to 83%; (2) Referral and nurses9 assessment forms completion increased (n: 170 to 6800 &amp; 23 to 540, respectively). Conclusion: The deterioration dashboard is an effective real time data- driven method for improving the quality of managing deteriorating patients. Improving the dashboard by integrating multiple health systems, a wider analysis of further NEWS2 and escalation of care metrics, clinicians learning of digital solutions will enhance functionality and experience, potentially boosting its value. There is a need to examine the generalizability of the dashboard through further validation and quality improvement studies.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.28.22276946v1" target="_blank">Evaluating a novel, integrative dashboard for health professionals performance in managing deteriorating patients: quality improvement project</a>
</div></li>
<li><strong>Changing word meanings in biomedical literature reveal pandemics and new technologies</strong> -
<div>
While we often think of words as having a fixed meaning that we use to describe a changing world, words are also dynamic and changing. Scientific research can also be remarkably fast-moving, with new concepts or approaches rapidly gaining mind share. We examined scientific writing, both preprint and pre-publication peer-reviewed text, to identify terms that have changed and examine their use. One particular challenge that we faced was that the shift from closed to open access publishing meant that the size of available corpora changed by over an order of magnitude in the last two decades. We developed an approach to evaluate semantic shift by accounting for both intra- and inter-year variability using multiple integrated models. Using this strategy and examining year-by-year changes revealed thousands of change points in both corpora. We found change points for tokens including ‘cas9’, ‘pandemic’, and ‘sars’ among many others. The consistent change-points between pre-publication peer-reviewed and preprinted text were largely related to the COVID-19 pandemic. We developed a web app for exploration (https://greenelab.github.io/word-lapse/) that enables users to investigate individual terms. To our knowledge, this analysis is the first to examine the semantic shift in biomedical preprints and pre-publication peer-reviewed text, and it lays the foundation for future work to examine how terms acquire new meaning and the extent to which that process is encouraged or discouraged by peer review.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.27.497742v1" target="_blank">Changing word meanings in biomedical literature reveal pandemics and new technologies</a>
</div></li>
<li><strong>The Origin of Immunity by Means of Prior Infection and Vaccination with Implications for the Origin of Species</strong> -
<div>
The expectation that vaccines would solve the COVID-19 problem through herd immunity, which followed logical deductions from inflammatory phenomena in which Mechnikov and his contemporaries described immunity as originating from the elimination of pathogens by a system of cells and substances which has since been named the immune system which would prevent onward transmission of the pathogen, has failed to find representation in reality. But upon illustrating the reality in which the immunological phenomena through which immune mechanisms protect us from the pathological manifestations that occur in response to the pathogen, they were found to be brought about by the attenuation of the causative influence of the same pathogen from a prior infection and an entity that is immunologically-linked with the pathogen from vaccination so that the single pathway through which such pathological manifestations are brought in response to these influences are blocked and infection with the pathogen remains asymptomatic for as long as either or both of the conditions that hive rise to different but connected paths to immunity persist. Rather than asymptomatically hosted variants and subvariants to have become masters in the art of escaping the system which we have described as immune for in the absence of knowledge of reality for severe manifestations to occur in both the vaccinated and unvaccinated or to have become more transmissible for surges of COVID-19 hospitalizations and death to occur, it is these protective conditions that give rise to immunity that needs to disappear. And the higher likelihood of one path disappearing in the unvaccinated than both disappearing in the vaccinated explains why the unvaccinated are at greater risk of such unfortunate events. If we will put an end to such deaths which claimed the lives of millions prematurely during this pandemic and prevent those which may decimate our populations if pathological manifestations such as malignancies should appear catastrophically in our species as they did in Tasmanian devils, an understanding of the immunological nature of the pathological effects of the pathogens that are linked with these manifestations, which will enable us to keep both conditions stable in the vaccinated until eradication occurs, must be our topmost research priority now.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/py8ju/" target="_blank">The Origin of Immunity by Means of Prior Infection and Vaccination with Implications for the Origin of Species</a>
</div></li>
<li><strong>The COVID-19 pandemic sparked off a large-scale outbreak of carbapenem-resistant Acinetobacter baumannii from the endemic strains of an Italian hospital</strong> -
<div>
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<i>Acinetobacter baumannii</i> is an insidious nosocomial pathogen that poses a serious threat due to the rise of incidence of multidrug resistant (MDR) strains. During the COVID-19 pandemic, MDR <i>A. baumannii</i> clones have caused several outbreaks worldwide. Here we describe a detailed investigation of an MDR <i>A. baumannii</i> outbreak that occurred at Fondazione IRCCS Policlinico San Matteo (Pavia, Italy). A total of 96 <i>A. baumannii</i> strains, isolated between January and July 2020 from 41 inpatients (both SARS-CoV-2 positive and negative) in different wards, were characterized by phenotypic and genomic analyses combining Illumina and Nanopore sequencing. Antibiotic susceptibility testing revealed that all isolates were resistant to carbapenems and the sequence analysis attributed this to the carbapenemase gene <i>bla</i><sub>OXA-23</sub>. Screening of virulence factors unveiled that all strains carried determinants for biofilm formation. A core genome-based phylogeny was inferred to integrate outbreak strain genomes with background genomes from public databases and the local surveillance program. All strains belonged to the globally disseminated ST2 clone and were divided into two main clades. Strains from the outbreak clustered with surveillance isolates from 2019, suggesting that the outbreak was caused by two strains that were already circulating in the hospital before the start of the pandemic. The intensive spread of <i>A. baumannii</i> in the hospital was enhanced by the extreme emergency situation of the first COVID-19 pandemic wave that resulted in minor attention to infection prevention and control practices.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.28.22276851v1" target="_blank">The COVID-19 pandemic sparked off a large-scale outbreak of carbapenem-resistant Acinetobacter baumannii from the endemic strains of an Italian hospital</a>
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<li><strong>BNT162b2 effectiveness against Delta &amp; Omicron variants in teens by dosing interval and duration</strong> -
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Background and Objectives Two- and three-dose BNT162b2 (Pfizer-BioNTech) mRNA vaccine effectiveness (VE) against SARS-CoV-2 infection, including Delta and Omicron variants, was assessed among adolescents in two Canadian provinces where first and second doses were spaced longer than the manufacturer-specified 3-week interval. Methods Test-negative design estimated VE against laboratory-confirmed SARS-CoV-2 infection among adolescents 12-17 years old in Quebec and British Columbia, Canada between September 5, 2021 (epi-week 36), and April 30, 2022 (epi-week 17). Delta-dominant and Omicron-dominant periods spanned epi-weeks 36-47 and 51-17, respectively. VE was assessed from 14 days and explored by interval between first and second doses, time since second dose, and with administration of a third dose. Results Median first-second dosing-interval was ~8 weeks and second-third dosing-interval was ~28-31 weeks. Median follow-up post-second-dose was ~10-11 weeks for Delta-dominant and ~21-22 weeks for Omicron-dominant periods, and ~3-9 weeks post-third dose. VE against Delta was ≥90% to at least the 5th month post-second dose. VE against Omicron declined from ~65-75% at 2-3 weeks to ≤50% by the 3rd month post-vaccination, restored to ~60-65% shortly following a third dose. VE exceeded 90% against Delta regardless of dosing-interval but appeared improved against Omicron with ≥8 weeks between first and second doses. Conclusion In adolescents, two BNT162b2 doses provided strong and sustained protection against Delta but reduced and rapidly-waning VE against Omicron. Longer interval between first and second doses and a third dose improved Omicron protection. Updated vaccine antigens, increased doses and/or dosing-intervals may be needed to improve adolescent VE against immunological-escape variants.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.27.22276790v1" target="_blank">BNT162b2 effectiveness against Delta &amp;amp; Omicron variants in teens by dosing interval and duration</a>
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<li><strong>Outcomes of laboratory-confirmed SARS-CoV-2 infection during resurgence driven by Omicron lineages BA.4 and BA.5 compared with previous waves in the Western Cape Province, South Africa</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objective: We aimed to compare clinical severity of Omicron BA.4/BA.5 infection with BA.1 and earlier variant infections among laboratory-confirmed SARS-CoV-2 cases in the Western Cape, South Africa, using timing of infection to infer the lineage/variant causing infection. Methods: We included public sector patients aged ≥20 years with laboratory-confirmed COVID-19 between 1-21 May 2022 (BA.4/BA.5 wave) and equivalent prior wave periods. We compared the risk between waves of (i) death and (ii) severe hospitalization/death (all within 21 days of diagnosis) using Cox regression adjusted for demographics, comorbidities, admission pressure, vaccination and prior infection. Results: Among 3,793 patients from the BA.4/BA.5 wave and 190,836 patients from previous waves the risk of severe hospitalization/death was similar in the BA.4/BA.5 and BA.1 waves (adjusted hazard ratio (aHR) 1.01; 95% confidence interval (CI) 0.92; 1.12). Both Omicron waves had lower risk of severe outcomes than previous waves. Prior infection (aHR 0.19, 95% CI 0.16; 0.22) and vaccination (aHR 0.24; 95% CI 0.15; 0.39 for boosted vs. no vaccine) were protective. Conclusion: Disease severity was similar amongst diagnosed COVID-19 cases in the BA.4/BA.5 and BA.1 periods in the context of growing immunity against SARS-CoV-2 due to prior infection and vaccination, both of which were strongly protective.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.28.22276983v1" target="_blank">Outcomes of laboratory-confirmed SARS-CoV-2 infection during resurgence driven by Omicron lineages BA.4 and BA.5 compared with previous waves in the Western Cape Province, South Africa</a>
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<li><strong>Impact of COVID-19 on the management and outcomes of ureteric stones in the UK: a multicentre retrospective study</strong> -
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Objectives: To determine if management of ureteric stones in the United Kingdom changed during the COVID-19 pandemic and whether this affected patient outcomes. Patients and methods: We conducted a multicentre retrospective study of adults with CT-proven ureteric stone disease at 39 UK hospitals during a pre-pandemic period (23/3/19 to 22/6/19) and a period during the pandemic (the 3-month period after the first SARS-CoV-2 case at individual sites). The primary outcome was success of primary treatment modality, defined as no further treatment required for the index ureteric stone. Our study protocol was published prior to data collection. Results: A total of 3735 patients were included (pre-pandemic=1956 patients; pandemic=1779 patients). Stone size was similar between groups (p&gt;0.05). During the pandemic, patients had lower hospital admission rates (pre-pandemic=54.0% vs pandemic=46.5%, p&lt;0.001), shorter length of stay (mean=4.1 vs. 3.3 days, p=0.02), and higher rates of use of medical expulsive therapy (17.4% vs. 25.4%, p&lt;0.001). In patients who received interventional management (pre-pandemic n=787 vs. pandemic n=685), rates of ESWL (22.7% vs. 34.1%, p&lt;0.001) and nephrostomy were higher (7.1% vs. 10.5%, p=0.03); and rates of ureteroscopy (57.2% vs. 47.5%, p&lt;0.001), stent insertion (68.4% vs. 54.6%, p&lt;0.001), and general anaesthetic (92.2% vs. 76.2%, p&lt;0.001) were lower. There was no difference in success of primary treatment modality between patient cohorts (pre-pandemic=73.8% vs. pandemic=76.1%, P=0.11), nor when patients were stratified by treatment modality or stone size. Rates of operative complications, 30-day mortality, and readmission and renal function at 6 months did not differ between the data collection periods. Conclusions: During the COVID-19 pandemic, there were lower admission rates and fewer invasive procedures performed. Despite this, there were no differences in treatment success or outcomes. Our findings indicate that clinicians can safely adopt management strategies developed during the pandemic to treat more patients conservatively and in the community.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.27.22276955v1" target="_blank">Impact of COVID-19 on the management and outcomes of ureteric stones in the UK: a multicentre retrospective study</a>
</div></li>
<li><strong>Do Media Objectivity and Frequency of Informing Mediate the Relationship Between Traditionalist Social Attitudes and COVID-19 Conspiracy Beliefs?</strong> -
<div>
In this study, we hypothesized that traditionalist social attitudes (conservatism, religiousness, and authoritarianism) significantly predict COVID-19 conspiracy beliefs (Hiding Information and Harmless Virus), as well as conspiracy mentality in general. We also hypothesized that these relationships are mediated by the objectivity of the media through which individuals inform themselves, and the frequency of informing. The sample consisted of 341 participants from Serbia (mean age 33.51 years), of which 40.5% were women. The results revealed that conservatism predicts both conspiracy belief sets and conspiracy mentality, authoritarianism only COVID-19 conspiracy beliefs, and religiousness only beliefs that the virus is harmless. Media objectivity does not mediate these relationships. The frequency of informing is a significant mediator only of the relationships between authoritarianism, and conspiracy beliefs and conspiracy mentality, indicating that the role of seeking information is in reducing the threat perceived by more authoritarian individuals. The study reveals that media objectivity might not play a role in reducing conspiracy beliefs. An explanation might be found in the importance of the perceived credibility of the media.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/9tq23/" target="_blank">Do Media Objectivity and Frequency of Informing Mediate the Relationship Between Traditionalist Social Attitudes and COVID-19 Conspiracy Beliefs?</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunobridging Study of COVID-19 Protein Subunit Recombinant Vaccine</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVID-19 Protein Subunit Recombinant Vaccine;   Biological: Active Comparator<br/><b>Sponsors</b>:   PT Bio Farma;   Faculty of Medicine, Universitas Indonesia, Jakarta;   Faculty of Medicine, Diponegoro University, Semarang;   Faculty of Medicine, Universitas Andalas, Padang;   Faculty of Medicine, Universitas Hassanudin, Makassar<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate the Safety, Tolerability, and Immunogenicity of SARS-CoV-2 Variant (COVID-19 Omicron) mRNA Vaccine (Phase 1)</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: ABO1009-DP<br/><b>Sponsor</b>:   Suzhou Abogen Biosciences Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate Safety, Tolerability, and Immunogenicity of SARS-CoV-2 Variant (COVID-19) mRNA Vaccines</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: ABO1009-DP;   Biological: ABO-CoV.617.2;   Other: Placebo<br/><b>Sponsor</b>:   Suzhou Abogen Biosciences Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discussing COVID-19 Vaccines in Private Facebook Groups</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Gist messages on COVID-19 vaccination;   Behavioral: COVID-19 vaccine information<br/><b>Sponsor</b>:   George Washington University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety Study of One Booster Dose of Trivalent COVID-19 Vaccine (Vero Cell), Inactivated</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Trivalent COVID-19 Vaccine (Vero Cell), Inactivated, Prototype Strain, Delta Strain and Omicron Strain;   Biological: COVID-19 Vaccine (Vero Cell), Inactivated<br/><b>Sponsors</b>:   Sinovac Biotech (Colombia) S.A.S.;   Sinovac Life Sciences Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Home-Based Exercise Tele-Rehabilitation After COVID-19</strong> - <b>Condition</b>:   Post SARS-CoV2 (COVID-19)<br/><b>Intervention</b>:   Other: Tele-exercise<br/><b>Sponsors</b>:   VA Office of Research and Development;   Baltimore Veterans Affairs Medical Center;   Salem Veterans Affairs Medical Center<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMM-BCP-01 in Mild to Moderate COVID-19</strong> - <b>Conditions</b>:   SARS-CoV2 Infection;   COVID-19<br/><b>Interventions</b>:   Drug: IMM-BCP-01;   Drug: Placebo<br/><b>Sponsors</b>:   Immunome, Inc.;   United States Department of Defense<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mesenchymal Stromal Cells for the Treatment of Patients With COVID-19.</strong> - <b>Conditions</b>:   COVID-19 Pneumonia;   COVID-19<br/><b>Interventions</b>:   Biological: Mesenchymal stem cell;   Other: Placebo<br/><b>Sponsors</b>:   Paulo Brofman;   Conselho Nacional de Desenvolvimento Científico e Tecnológico<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Self-Amplifying Messenger Ribonucleic Acid (samRNA) Vaccines Against COVID-19 in Healthy Adults and People Living With Human Immunodeficiency Virus (HIV)</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2<br/><b>Interventions</b>:   Drug: GRT-R912, samRNA-Spikebeta-TCE11;   Drug: GRT-R914, samRNA-Spikebeta-TCE9;   Drug: GRT-R918, samRNA-SpikeOmicron-N-TCE11<br/><b>Sponsor</b>:   Gritstone bio, Inc.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ACE2 Chewing Gum on SARS-CoV-2 Viral Load (COVID 19)</strong> - <b>Condition</b>:   SARS-CoV-2<br/><b>Interventions</b>:   Drug: ACE2 Chewing Gum;   Other: Placebo Chewing Gum<br/><b>Sponsor</b>:   University of Pennsylvania<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Olfactory Training in COVID-19 Associated Loss of Smell</strong> - <b>Conditions</b>:   COVID-19;   Hyposmia<br/><b>Intervention</b>:   Device: Sniffin’ sticks Duftquartett<br/><b>Sponsor</b>:   Medical University Innsbruck<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Psychological Impact of Medical Evacuations on Families of Patients Admitted to Intensive Care Unit for Severe COVID-19</strong> - <b>Conditions</b>:   COVID-19;   Stress Disorders, Post-Traumatic<br/><b>Interventions</b>:   Other: Revised Impact of Event Scale;   Other: Hospital Anxiety and Depression scale;   Other: 36-Item Short Form Survey;   Other: satisfaction survey;   Other: semi-directed interview with trusted person on the general experience of the patient’s medical evacuation;   Other: semi-directed interview with trusted person on the general experience of hospitalization in intensive care<br/><b>Sponsor</b>:   Centre Hospitalier Metropole Savoie<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of COVID-19 on Platelet Mitochondrial Bioenergetic, Antioxidants and Oxidative Stress in Infertile Men.</strong> - <b>Conditions</b>:   Infertility, Male;   COVID-19<br/><b>Intervention</b>:   Other: diagnostic test and sperm analysis<br/><b>Sponsors</b>:   Comenius University;   GYN-FIV<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Clinical Trial of SARS-CoV-2 mRNA Vaccine(LVRNA009) as Heterologous Booster in Islamabad</strong> - <b>Condition</b>:   SARS-CoV-2<br/><b>Interventions</b>:   Biological: LVRNA009;   Biological: CoronaVac®<br/><b>Sponsor</b>:   AIM Vaccine Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Evaluate Immunogenicity and Safety of MVC-COV1901 Vaccine Compared With AZD1222</strong> - <b>Condition</b>:   COVID-19 Vaccine<br/><b>Interventions</b>:   Biological: MVC-COV1901;   Biological: AZD1222<br/><b>Sponsor</b>:   Medigen Vaccine Biologics Corp.<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Electrospun nanofibrous membrane with antibacterial and antiviral properties decorated with Myoporum bontioides extract and silver-doped carbon nitride nanoparticles for medical masks application</strong> - Public health safety issues have been plaguing the world since the pandemic outbreak of coronavirus disease (COVID-19). However, most personal protective equipments (PPE) do not have antibacterial and anti- toxicity effects. In this work, we designed and prepared a reusable, antibacterial and anti-toxicity Polyacrylonitrile (PAN) based nanofibrous membrane cooperated with Ag/g-C(3)N(4) (Ag-CN), Myoporum.bontioides (M.bontioides) plant extracts and Ag nanoparticles (NPs) by an…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy</strong> - A characteristic feature of COVID-19, the disease caused by SARS-CoV-2 infection, is the dysregulated immune response with impaired type I and III interferon (IFN) expression and an overwhelming inflammatory cytokine storm. RIG-I-like receptors (RLRs) and cGAS-STING signaling pathways are responsible for sensing viral infection and inducing IFN production to combat invading viruses. Multiple proteins of SARS-CoV-2 have been reported to modulate the RLR signaling pathways to achieve immune…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Exploring antiviral and anti-inflammatory effects of thiol drugs in COVID-19</strong> - The redox status of the cysteine-rich SARS-CoV-2 spike glycoprotein (SARS-2-S) is important for binding of SARS-2-S to ACE2, suggesting that drugs with a functional thiol group (“thiol drugs”) may cleave cystines to disrupt SARS-CoV-2 cell entry. In addition, neutrophil-induced oxidative stress is a mechanism of COVID-19 lung injury, and the antioxidant and anti-inflammatory properties of thiol drugs, especially cysteamine, may limit this injury. To first explore antiviral effects of thiol drugs…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting and Modulation of the Natriuretic Peptide System in Covid-19: A single or double-edged effect?</strong> - Natriuretic peptide system [NPS] is a group of peptide hormones or paracrine factors, including atrial natriuretic peptide [ANP], brain natriuretic peptide [BNP], and natriuretic peptide precursor C [NPC], that are structurally related. The physiological effects of NPS include natriuresis, increased glomerular filtration rate, inhibition release of renin, vasopressin, and aldosterone, sympathetic inhibition, vasodilatations, and prevents cardiac hypertrophy and remodeling. ANP has immunological…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Analysis of Interaction between odorant receptors and flexible spike of SARS CoV-2- key to loss of smell</strong> - The vaccine development for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily focused on structure of the spike (S) protein. The heavy glycosylation of S with flexible hinges at stalk shields from antibodies. The flexible nature of hinges may be one of the important factors which are responsible for binding the odorant receptor of those neurons which are responsible for the loss of smell in patients with COVID-19 infection. In this study strong and stable bond formation…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ongoing positive selection drives the evolution of SARS-CoV-2 genomes</strong> - SARS-CoV-2 is a new RNA virus affecting humans and spreads extensively through world populations since its first outbreak in December, 2019. Whether the transmissibility and pathogenicity of SARS-CoV-2 in humans after zoonotic transfer are actively evolving, and driven by adaptation to the new host and environments is still under debate. Understanding the evolutionary mechanism underlying epidemiological and pathological characteristics of COVID-19 is essential for predicting the epidemic trend,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Assessment of disinfectant efficacy in reducing microbial growth</strong> - The incidence of hospital- and community-acquired infections has been dramatically increased worldwide. Accordingly, hands hygiene and the use of disinfectants have been increased leading to the expansion in hand sanitizers production to meet public demand. This study was conducted to assess the efficiency of common disinfectants in the market of Riyadh, Saudi Arabia in inhibiting the microbial growth during the time of Coronavirus disease 2019 (COVID-19) pandemic. Five bacterial strains of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Apixaban, an orally available anticoagulant, inhibits SARS-CoV-2 replication and its major protease in a non-competitive way</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and related sarbecoviruses enter host cells by receptor-recognition and membrane-fusion. An indispensable step in fusion is the formation of 6-helix bundle by viral spike heptad repeats 1 and 2 (HR1 and HR2). Here, we report the construction of 5-helix bundle (5HB) proteins for virus infection inhibition. The optimal construct inhibits SARS-CoV-2 pseudovirus entry with sub-micromolar IC50. Unlike HR2-based peptides that cannot bind…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 Spike interaction with hACE2</strong> - Efficient quantitative assays for measurement of viral replication and infectivity are indispensable to future endeavors to develop prophylactic or therapeutic antiviral drugs or vaccines against SARS-CoV-2. We developed a SARS-CoV-2 cell-cell transmission assay that provides a rapid and quantitative readout to assess SARS-CoV-2 Spike hACE2 interaction in the absence of pseudotyped particles or live virus. We established two well-behaved stable cell lines, which demonstrated a remarkable…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 - A Proof-of-Concept Study</strong> - Coronavirus disease 2019 (COVID-19) is a systemic disease associated with injury (thinning) of the endothelial glycocalyx (eGC), a protective layer on the vascular endothelium. The aim of this translational study was to investigate the role of the eGC-degrading enzyme heparanase (HPSE), which is known to play a central role in the destruction of the eGC in bacterial sepsis. Excess activity of HPSE in plasma from COVID-19 patients correlated with several markers of eGC damage and perfused…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Neutrophil Extracellular Traps, Sepsis and COVID-19 - A Tripod Stand</strong> - The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Majority of COVID-19 patients have mild disease but about 20% of COVID-19 patients progress to severe disease. These patients end up in the intensive care unit (ICU) with clinical manifestations of acute respiratory distress syndrome (ARDS) and sepsis. The formation of neutrophil extracellular traps (NETs) has also been associated with severe…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations</strong> - COVID-19 has proven to be particularly serious and life-threatening for patients presenting with pre-existing pathologies. Patients affected by rheumatic musculoskeletal disease (RMD) are likely to have impaired immune responses against SARS-CoV-2 infection due to their compromised immune system and the prolonged use of disease-modifying anti-rheumatic drugs (DMARDs), which include conventional synthetic (cs) DMARDs or biologic and targeted synthetic (b/ts) DMARDs. To provide an integrated…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Seroprevalence of Anti-S1-RBD Antibodies in Pre-pandemic and Pandemic Subjects From Hail Region, KSA</strong> - CONCLUSION: Antibody levels increased in samples collected during the pandemic, even though these subjects were not clinically COVID-19 positive. A small number of pre-pandemic subjects showed serum antibodies, suggesting prior exposure to other coronaviruses in the region. With dwindling neutralizing antibody levels and reduced vaccine efficacy against newer variants, it remains crucial to develop better assays for surveillance, management, and future research.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 infects an <em>in vitro</em> model of the human developing pancreas through endocytosis</strong> - Recent studies showed that SARS-CoV-2 can infect adult human pancreas and trigger pancreatic damage. Here, using human fetal pancreas samples and 3D differentiation of human pluripotent cells into pancreatic endocrine cells, we determined that SARS-CoV-2 receptors ACE2, TMPRSS2 and NRP1 are expressed in precursors of insulin-producing pancreatic β-cells, rendering them permissive to SARS-CoV-2 infection. We also show that SARS-CoV-2 enters and undergoes efficient replication in human multipotent…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Political Lessons for Democrats in a Post-Roe America</strong> - Democrats can look across the aisle if they want pointers on how to overcome the challenges of an unrepresentative political system, a stacked Court, and their internal divisions. - <a href="https://www.newyorker.com/news/our-columnists/political-lessons-for-democrats-in-a-post-roe-america">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The “Gap” in the Constitution That Led to January 6th</strong> - Trump and his allies exploited key vulnerabilities in the electoral process. Is the biggest one Congress itself? - <a href="https://www.newyorker.com/news/q-and-a/the-gap-in-the-constitution-that-led-to-january-6th">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Supreme Court Decision That Defined Abortion Rights for Thirty Years</strong> - The centrist, compromising view of reproductive rights in Planned Parenthood v. Casey helped clear the path to overturn Roe v. Wade. - <a href="https://www.newyorker.com/news/daily-comment/the-supreme-court-decision-that-defined-abortion-rights-for-thirty-years">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kathy Hochul Is Here to Stay</strong> - Andrew Cuomo’s successor, once seen as a placeholder, is poised to run New York’s state government for the next half decade. - <a href="https://www.newyorker.com/news/our-local-correspondents/kathy-hochul-is-here-to-stay">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cassidy Hutchinson’s Testimony Should Be the End of Donald Trump</strong> - Regardless of the legal obstacles to convicting the former President, Hutchinson’s testimony reconfirmed that he must never again be allowed anywhere near power. - <a href="https://www.newyorker.com/news/our-columnists/cassidy-hutchinsons-testimony-should-be-the-end-of-donald-trump">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>The nontoxic social media app that tells you your toxic traits</strong> -
<figure>
<img alt="Screenshot of the Dimensional app listing personality traits." src="https://cdn.vox-cdn.com/thumbor/lYpDVd6BHv__qpZ-8KjpS1kvFgw=/240x0:1680x1080/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71028465/Untitled_design__9_.0.png"/>
<figcaption>
Sounds about right. | Dimensional/Rebecca Jennings
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Personality tests are mostly bogus. Dimensional is fun anyway.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ygLE05">
I have a confession, which is that although I deeply dislike the way the <a href="https://www.vox.com/the-goods/2021/9/30/22696338/pathologizing-adhd-autism-anxiety-internet-tiktok-twitter">internet encourages us to pathologize each other and ourselves</a> — the overuse (and often misuse) of terms like “emotional labor,” “dissociation” or “sapiosexual” to label everyday phenomena, for instance — I love personality quizzes, which effectively do the same thing. In the parlance of personality quizzes, your everyday behaviors and thought patterns take on spectacular special meanings; you’re not just “adventurous” or “athletic,” you’re a <em>Gryffindor</em>. You’re not obsessive in love, you’re <em>anxious-attached</em>. You’re more than just playful and impulsive, you’re an <em>Enneagram Type 7</em>, a designation I share with <a href="https://www.enneagraminstitute.com/type-7">Joe Biden, Paris Hilton, and Mozart</a>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8rBgV6">
A few weeks ago, I made a new friend (I’m an extrovert!) who told me about an app she was obsessed with called <a href="https://www.dimensional.me/">Dimensional</a>. Basically, you take a series of personality quizzes, and then the app compares you to your loved ones who are also on the app: how similarly you behave in the workplace, how compatible you are in love, whether you share the same values. I downloaded it immediately and then wrangled as many friends as I could to do the same.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3QO2bg">
Like Co-Star, the <a href="https://www.theverge.com/2019/10/4/20879631/co-star-astrology-app-zodiac-signs">wildly popular astrology app</a> that sends its users wry daily missives like “Start a cult” or personal negs like “Maybe you just need a roll in the hay,” Dimensional contains a fair bit of Instagram bait. After you’re done with all the assessments — there are currently 10 of them, relating to things like “conflict style” and “values;” completing them all takes about an hour — Dimensional will serve you “stories,” or Instagram-ready slides listing your “worst habits in love” or “most toxic traits.” (“Taking it personally when other people want alone time” and “crushing on everyone” ripped me to shreds.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="76DR5p">
Its pleasant-looking UX is far from the most fun part about Dimensional. Once you’ve forced a friend to join, you can read an AI’s opinion of your relationship. On my best friend and me: “Rebecca not only loves when they’re told how someone feels about them, they usually need to hear these affirmations to feel appreciated. Mary Kate does not express gratitude or affirmation instinctively.” On another friend and me: “You’re the Bonnie and Clyde of relationships. You two seek independence from the world — not each other.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GDDnJD">
These little insights aren’t interesting to anyone but us, obviously. No personality test is, which is exactly why they’re such good respites from traditional social media: There are no photos, no liking, no performing for an imagined mass of invisible strangers. Rather than act as brands and media companies and megaphones, we reflect on our own humanness — and then, yes, upload that data into the cloud.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SJZ1Sd">
We’ve endured more than a decade of discourse and academic research on whether anyone is really “themselves” on the internet, and we’re now at the stage where a crop of social media platforms have marketed themselves as <a href="https://www.vox.com/the-goods/23075161/bereal-app-authenticity-posting-self">“anti-Instagram” apps</a>: no self-promotion, no ads, no chance at getting famous. Out of them all — Dispo, Poparazzi, BeReal — only the latter has seemed to transcend fad status, although it’s still early in its popularity.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Vv98Qp">
Dimensional doesn’t bear many similarities to these apps. For one, the entire premise of Dimensional relies on what is essentially a one-time experience: You take the quizzes, you wait for your friends to take them, then you compare. There’s a limit on how much time you spend there, which prevents it from attracting the kind of venture capital that helped early social media startups launch but demands growth — more users, more engagement, more ad dollars — at all costs. Paradoxically, that’s exactly what makes it so pleasurable to use: You can get burnt out by the neverending churn of your TikTok or Twitter feeds, but using Dimensional is more like reading an article starring yourself.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TGb6bT">
Personality tests have always been a little cheesy and a little scoffed at, and probably for good reason. As my colleague <a href="https://www.vox.com/culture/2017/8/3/16035100/personality-quizzes-fake-hogwarts-meyers-briggs-mbti-astrology-zodiac">Constance Grady has noted</a>, the most famous, Myers-Briggs, revolves around dualities that don’t actually exist and uses dated Jungian theories as justification for its scientific claims. They satisfy human beings’ instinct for tribalism: Being sorted into a group makes us feel more comfortable. What’s more, we’ll start to identify with that group no matter what it actually is, a phenomenon known as the Barnum effect. We’ve been typifying people as far back as 400 BC, when Hippocrates believed that every person belonged to one of the four humors. The more modern roots of the personality quiz lie in women’s magazines, which <a href="https://archives.cjr.org/behind_the_news/in_search_of_the_ur-quiz.php">started including many more front-of-book</a> games and puzzles post-World War I. By the 2010s, an entire venture-backed media company relied on <a href="https://www.businessinsider.com/how-quizzes-affected-buzzfeeds-facebook-traffic-in-2014-2014-6">addictive quizzes to skyrocket its growth</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ml0mOH">
Personality testing takes on a more complicated meaning in the age of Big Data. If you’re a person who has high “neuroticism” in your Big Five personality chart, you likely see an app like Dimensional as a field day for data privacy abuse. This is a fair concern: In the lead-up to the 2016 presidential election, the data firm <a href="https://www.vox.com/policy-and-politics/2018/3/23/17151916/facebook-cambridge-analytica-trump-diagram">Cambridge Analytica used widely shared personality quizzes</a> to compile data on 87 million Facebook users without them knowing. With access to more intimate details than demographics or hobbies — what makes someone anxious, what they fear, how they form relationships — it’s not difficult to imagine a worst-case scenario.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R9QrV9">
Even so, concerns over what information a relatively tiny app contains about you feel like missing the forest for the trees: What use is my “love language” compared to a <a href="https://www.nytimes.com/2020/08/19/technology/smartphone-location-tracking-opt-out.html">constant log of where I go and who I associate with</a>, which my smartphone already has? I can’t possibly be angry that Dimensional knows my ideal partner is “someone who tells me I’m hot” or that my elemental spirit is “Air” (???). I guess I can sort of be angry that Dimensional told me that I am lower on the “Thinking” function than 85 percent of users, which seems rude.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SRonid">
Mostly, though, I’m reminded of what those little personality quizzes in women’s magazines meant to mid-century housewives, or to me, bored and alone in my room as a child. “They needed things to fill their time,” <a href="https://www.newyorker.com/culture/culture-desk/the-enduring-allure-of-the-personality-quiz">explains the New Yorker’s</a> Maria Konnikova of the initial wave of magazine personality quizzes. “They needed other ways to signal, ‘I’m alive! This is me, this is who I am’ and quizzes were a way of doing that, whereas men had their careers.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hFwY80">
This is what personality tests feel like to me — less exercises in narcissism and more opportunities to reflect, to think about the kinds of things we’re prevented from thinking about by the demands of modern life. “Look, it’s us,” I text my friends, one by one, as I send them Dimensional’s comparisons. Look how alive we are!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VFfpOX">
<em>This column was first published in The Goods newsletter. </em><a href="https://www.vox.com/pages/newsletters"><em>Sign up here</em></a><em> so you don’t miss the next one, plus get newsletter exclusives.</em>
</p></li>
<li><strong>Anyone can fall for online scams — even you. Here’s how to avoid them.</strong> -
<figure>
<img alt="Cartoon drawing of people on laptops with dollar bills flying away on wings." src="https://cdn.vox-cdn.com/thumbor/EpeftwRD-VgGUjG6c11VnfhOL7I=/288x0:3488x2400/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71028250/GettyImages_1329480824_money.0.jpg"/>
<figcaption>
Online scams will make your money fly away. | Denis Novikov/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
From spam texts to payment app fraud to crypto tricks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="l1oqQG">
Alison Giordano just wanted to help out a friend, but instead, she almost lost her Instagram account.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EmnQcB">
The scam was pretty sneaky: A friend messaged Giordano (who, full disclosure, is a friend of mine) on Instagram asking if she could help her win a contest. The friend would send her a text with a link, and all Giordano had to do was take a screenshot of the text and send it back to her friend. Giordano did as instructed. Moments later, she got an email from Instagram saying someone logged into her account from a different location on a different device.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6yzciW">
A screenshot that causes your account to be hacked sounds like a lower-stakes but higher-tech version of <em>The Ring</em>, but what happened to Giordano is actually quite simple. There was no contest, and the text didn’t come from her friend. Giordano’s friend (or, almost certainly, someone who took over her friend’s account and was pretending to be her friend) went to Instagram’s password reset page and requested a reset link for Giordano’s account. That prompted Instagram to send a text to Giordano with a link to access her Instagram account. The URL of the link was in the text, so when Giordano took the screenshot and sent it back, the scammer simply entered the URL in their device, and that let them access Giordano’s account — no password or supernatural curses necessary.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YFktwi">
Fortunately for Giordano, she saw Instagram’s email almost immediately and was able to get back into her account before the scammer took it over. She blocked her friend’s account, changed her password, and enabled <a href="https://www.vox.com/recode/22419794/authenticator-apps-and-you-authy-google-authenticator">two-factor authentication</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YQ9SLJ">
“I was just very naive and trusting,” Giordano tells me. “I felt pretty stupid when all was said and done.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EbEVRP">
She shouldn’t have. The Instagram messages came from what appeared to be a friend, and Giordano’s other friends have asked for her help with (real) social media-based contests in the past, so of course she didn’t think much of it. She certainly didn’t think sending a screenshot could compromise her account. Until we spoke, she didn’t even know how it happened — it took me a while to figure it out too, until <a href="https://mobile.twitter.com/tallpoppyhq/status/1530584650975936513">this tweet</a> warning about this kind of scam clarified things. If Giordano hadn’t seen that email from Instagram, her account might have been lost to her forever, probably going on to try to scam all of her friends.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LF1Ghi">
We’d like to think that scams happen to other people who aren’t as smart or savvy as we are. Many people who get scammed believe this, which is why the <a href="https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3852323">vast majority</a> of them will never report it: Either they don’t know they were scammed or they’re ashamed to admit that it happened to them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eqtnzP">
But it could happen to anyone, including you.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0R9Cpj">
“The reason why these scams work is because some of them are good,” Yael Grauer, content lead for Consumer Reports’ <a href="https://securityplanner.consumerreports.org/">Security Planner</a>, tells Vox. “Even though I think education is important, there’s a reason social engineering is a thing. You can’t be perfect and on guard all the time.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="08g0IN">
Scammers prey on our biggest fears and strongest desires. They get better all the time, so it’s worth your time to learn how to recognize their tactics. The mediums scammers use may change, but many of the underlying strategies stay the same — which means the recommendations for how to protect yourself from them do too.
</p>
<h3 id="CYjkd5">
Don’t panic …
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rzPtNq">
When I got an email saying there was a new login to my Twitter account from Moscow, my initial response was abject terror (My checkmark! My DMs! My reputation!). At first glance, the email looked a lot like the login confirmation emails that Twitter actually sends. Even the email address it was sent from was very close to the one Twitter uses for such notifications. I admit that I almost clicked on the account restoration link. Then the adrenaline wore off, and I realized that the email came from “twitter-act.com” and not “twitter.com.” It was sent to my work email, which isn’t attached to my Twitter account, and it had a typo. Most importantly, I remembered that some of <a href="https://twitter.com/pkafka/status/1506068606152548357">my co-workers</a> had gotten similar phishing emails only a few days before. I <a href="https://twitter.com/SaraMorrison/status/1506072154894393347">actually knew</a> to expect this one, but all of that fell out of my head for a few seconds — which was exactly the point.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ylNuoz">
“It’s really, really hard for us to access logical thinking when we’re in a heightened emotional state, and it’s so hard to get out of that state once you’ve engaged,” says Kathy Stokes, director of fraud prevention at the AARP. “If you feel an immediate sort of visceral, emotional reaction to something coming your way, try to let that be your red flag.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="TpnHie">
Scammers know that emotions make their job easier. People get careless or let their guard down, which is why so many scams start with urgent messages asking you to do something immediately: dispute an erroneous charge on your <a href="https://www.abcactionnews.com/money/consumer/taking-action-for-you/scammers-discover-new-way-to-trick-amazon-customers-tampa-bay-woman-loses-2-000">Amazon account</a>, fix your hacked social media account, avoid being arrested by the IRS police by settling a bill that for some reason can only be <a href="https://www.irs.gov/newsroom/holiday-scam-reminder-gift-cards-are-never-used-to-make-tax-payments">paid off in gift cards</a>. In almost every case, a legitimate message doesn’t need you to respond within the next 30 seconds. So take that 30 seconds to calm down and think before you click anything.
</p>
<h3 id="AznOLT">
… and don’t engage
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uVJQ8A">
If you get a message or call you weren’t expecting and don’t know, the best thing to do is ignore it. Even what appears to be a perfectly innocent wrong number text could be something more insidious: someone <a href="https://www.wrtv.com/news/wrtv-investigates/wrong-number-text-scam-popping-up-on-hoosier-phones-could-have-dire-consequences-if-you-respond#:~:text=When%20you%20respond%20%E2%80%9Csorry%2C%20wrong,money%2C%20or%20even%20explicit%20pictures.">trying to scam you</a> by starting up a conversation. I’ve gotten a few of those wrong number texts, and while I’d like to think they kept texting me back because of my sparkling wit and impeccable conversation skills, that almost certainly wasn’t the reason.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4gvctV">
“Someone texts something important enough for you to tell them it’s a wrong number and suddenly they’re like, ‘You sound like a great person,’” Grauer says. “For the most part, it’s almost always a scam.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UTz8BI">
Find your meet-cute somewhere else.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wzHOeO">
That’s especially true for the texts and calls you know are scams. You may think it’ll be cathartic to respond to those by cursing out the people who are trying to steal your money, but the best thing you can do is block the number and move on with your life. Engaging with a scammer tells them your phone number or email address has a real person on the other end of it, which will only set you up to get more texts and calls and emails.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x5kLDT">
“The basic rule of thumb is simply hang up, and call whatever enterprise you think called you directly,” Alex Quilici, CEO of robocall-blocking software company YouMail, explains. For example, if your “bank” calls, you should hang up, find the number of your bank on your debit card (or another official source, like its website), and call that number back. “That’s the 100 percent safe way to deal with the issue.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hcODjG">
Even better is stopping scam calls and texts from reaching you at all. Phone companies <a href="https://www.vox.com/recode/22882647/robocalls-robotexts-scams-stir-shaken-voip-extended-warranty">now offer</a> free spam-blocking services, which can identify and stop potential scam or spam calls. Some services can block potential spam texts: iOS devices have <a href="https://support.apple.com/guide/iphone/block-filter-and-report-messages-iph203ab0be4/ios">built-in text filters</a>, and Google’s Messages app can <a href="https://www.pcmag.com/how-to/block-robotexts-and-spam-messages">warn you</a> if a text seems suspicious.
</p>
<h3 id="Bjwrwd">
Don’t give out your password
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="z5xpEb">
This should be obvious by now, right? Clearly not, since it’s believed that <a href="https://www2.deloitte.com/my/en/pages/risk/articles/91-percent-of-all-cyber-attacks-begin-with-a-phishing-email-to-an-unexpected-victim.html">90 percent</a> of cyberattacks are the result of successful phishing schemes, where a hacker or scammer tricks victims into thinking they’re a trusted or known source to give their sensitive information to. Some are better than others. I’ve seen some knowledgeable people in my own life fall for <a href="https://www.graphus.ai/blog/one-in-three-employees-will-fall-for-phishing/">email-from-your-employer</a> attacks (they clicked the links, but I hope they all stopped short of giving out their passwords).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0XGRr5">
That’s why most businesses will tell you that they will never ask for your password, and authentication texts will usually say something like “[Company] will never ask you for this code.” Also, you should really stop using two-factor authentication with texts, which are <a href="https://www.cnet.com/news/privacy/do-you-use-sms-for-two-factor-authentication-heres-why-you-shouldnt/">much less secure</a> — use an <a href="https://www.vox.com/recode/22419794/authenticator-apps-and-you-authy-google-authenticator">authenticator app</a> instead. Google makes a popular one for both <a href="https://apps.apple.com/us/app/google-authenticator/id388497605">iOS</a> and <a href="https://play.google.com/store/apps/details?id=com.google.android.apps.authenticator2&amp;hl=en_US&amp;gl=US">Android</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xauHIH">
Scammers love to use social media to find victims, too. If you’ve ever so much as tweeted the word “hack,” you’ll get a series of what I like to call Twitter Scam Reply Guys, who will usually recommend that you contact someone they claim to know who can get your account back, as long as you give them your login credentials and/or pay them (<a href="https://www.vice.com/en/article/k7w39x/account-recovery-service-twitter-hacked-instagram-coinbase">don’t do this</a>).
</p>
<h3 id="2YRO27">
Know where links are taking you
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="opGOKi">
A common way people get hacked or scammed is through malicious links, often in their email, texts, or DMs. Always check where a link is taking you before you click on it, and only go to websites you trust. That’s easier said than done, of course; it can be hard to see where a link is directing you on a smaller mobile device, and shortened link services may make it impossible to know where you’ll end up. If you get a text from FedEx about a package delivery with a link, for example, you may not realize that the website it’s sending you to <a href="https://www.cbsnews.com/news/fedex-scam-text-message-package-phishing-smishing-tracking-number/">isn’t FedEx</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RT1LKz">
The best thing to do is go to a company’s website directly, rather than through a random link in a text you weren’t expecting in the first place. If you get a text that claims to be FedEx or Wells Fargo, go to FedEx.com or WellsFargo.com; don’t click the link on the text. And definitely don’t enter any of your sensitive information — like your credit card, social security number, or your password — on a site if you aren’t absolutely sure that it’s the site you think it is.
</p>
<h3 id="31T2NE">
Be very careful with payment apps
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MBj8ka">
<a href="https://www.ftc.gov/news-events/news/press-releases/2004/12/ftc-warns-consumers-about-check-overpayment-scams">Overpayment scams</a> — when someone sends you more money than you were expecting and then asks you to give them back the difference — have stood the test of time. Once it was paper checks and wire transfers. Payment apps have made it even easier.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bDfxjx">
In fact, peer-to-peer payment apps like Venmo, Zelle, and Cash App have made a lot of scams easier because it’s fairly seamless to send money through them, and those transfers are instantaneous. There’s a reason why those apps tell you over and over again to be sure that the person you’re sending money to is who you think they are: Once your money is sent, you often can’t get it back. These services <a href="https://www.nytimes.com/2022/03/06/business/payments-fraud-zelle-banks.html">don’t have the same protections</a> as, say, a credit card or, in <a href="https://www.paypal.com/c2/webapps/mpp/paypal-safety-and-security?locale.x=en_C2">some cases</a>, PayPal.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VU4qEg">
One example of how scammers exploit these apps (and human decency) is to send money to random accounts (like yours), then claim they sent it to the wrong person and ask you to please send the money back. Being nice, you send the money back, only to later discover that the money that was sent to you came from a stolen credit card. Now <a href="https://www.bbb.org/article/news-releases/22128-scam-alert-this-venmo-scam-sends-you-money-by-accident">you have to pay it back</a> — all of it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7gsWI8">
If you’re the recipient of extra or unexpected funds, don’t just send the money back to wherever it came from, even if the sender gives you a convincing sob story for why you should. The best thing to do is contact the payment app and deal with the matter through them, rather than directly with whoever sent you the money.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uPI9OW">
There are ways to protect yourself to a certain extent on these apps. Most will give you a way to verify that you’re sending money to the right person by confirming their email address or phone number first. Use these safeguards. Consumer Reports <a href="https://www.consumerreports.org/digital-payments/how-to-protect-peer-to-peer-payments-a1478958356/">suggests</a> connecting your peer-to-peer payment apps to a credit card instead of a bank account, as credit cards have more protections for fraudulent transactions. If the app won’t protect you, your credit card company might, though most payment apps make you pay a 3 percent fee on credit card transactions.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="cIWave">
It’s also a good idea to put a PIN code on those apps, so even if someone gets into your phone — say, if they <a href="https://www.wral.com/charlotte-man-warns-of-venmo-cell-phone-scam-after-losing-2-200/19913906/">ask to borrow it</a> to make an emergency call — they can’t get into your apps and send your money away. This will add an extra step to using your payment app, but an easily remembered four-digit PIN takes about a second to enter and could save you a lot of money.
</p>
<h3 id="ZyVpB5">
Don’t use crypto
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0tOFgn">
Even in the best of circumstances, crypto is a loosely (or barely) regulated market that’s <a href="https://www.vox.com/the-goods/23071245/bitcoin-price-crypto-ethereum-nfts-defi-stablecoin">as volatile as it is hard to understand</a>. That has helped make it a prime target for scammers and hackers. The decentralized aspect of crypto may be part of its appeal, but it’s a lot less appealing when you check your wallet one day and discover <a href="https://www.vice.com/en/article/y3v3ny/all-my-apes-gone-nft-theft-victims-beg-for-centralized-saviors">all your apes are gone</a>. Maybe you’ll get lucky and OpenSea will freeze trading of your stolen NFT in time, or Coinbase will <a href="https://www.bleepingcomputer.com/news/security/hackers-rob-thousands-of-coinbase-customers-using-mfa-flaw/">reimburse you</a> if your crypto was stolen through its own security flaw. But don’t <a href="https://www.fox35orlando.com/news/couples-digital-coinbase-account-hacked-24000-stolen">count on it</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9q97xD">
“The advice I give people is that if you don’t understand how it works, don’t get involved in it,” Sean Gallagher, a senior threat researcher at Sophos, says. “Considering that many people who consider themselves educated about crypto still manage to get scammed, it’s probably not a good idea for most people to get into cryptocurrency investing.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="F0SNpq">
While crypto is relatively new, many people are getting scammed through some of the oldest tricks in the book. Stokes, of the AARP, says she has seen “a ton” of scams where someone gains a victim’s trust and claims they can help <a href="https://www.aarp.org/money/scams-fraud/info-2019/cryptocurrency.html">invest their money</a> in crypto for a big return. The Federal Trade Commission <a href="https://www.vox.com/recode/23153469/bitcoin-crypto-scam-report-ftc">recently reported</a> that consumers lost $1 billion to crypto-based fraud between January 2021 and March 2022, with most of those losses coming from bogus investment scams — and most of those came from social media posts or ads. And those are just the losses people told the FTC about; again, most people don’t report being defrauded. These days, it’s <a href="https://www.vox.com/the-goods/23148474/crypto-celebrities-ftx-kim-kardashian-larry-david">easy</a> <a href="https://www.cnn.com/2022/05/12/investing/luna-terra-stablecoin-explained/index.html">enough</a> to lose money in “legitimate” crypto investments. Why make it even riskier?
</p>
<h3 id="MuYHlu">
Protect yourself from yourself
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZRoT4L">
One way to avoid getting scammed is to preemptively protect your accounts from your mistakes as much as possible. If Giordano had two-factor authentication on her Instagram account, the scammers wouldn’t have been able to get into it through the URL — they’d need the code from her authenticator, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2Elbih">
There are <a href="https://www.vox.com/recode/2020/1/28/21080122/avoid-hack-hacker-theft">a few ways</a> you can protect your accounts from getting hacked, including setting up two-factor authentication and using different passwords for everything via a password manager. You can lock things down even more by using <a href="https://www.theverge.com/2019/2/22/18235173/the-best-hardware-security-keys-yubico-titan-key-u2f">hardware authenticators</a> and <a href="https://www.nytimes.com/wirecutter/guides/online-security-built-in-antivirus-software/">anti-malware software</a>, which you can get for mobile devices too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="a9phmX">
“That’s what security software is supposed to do,” Mark Ostrowski, head of engineering at cybersecurity company Check Point, says. It should protect you from “a lapse in judgment or if the scam is really, really, really, really good.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Tb55jQ">
At a certain point, your security measures might feel like more trouble than they’re worth. I have to admit, things were easier when I didn’t have to juggle my password manager, two different authenticator apps, and text messages for the accounts where authenticator apps aren’t available. But I’d rather have to take an extra step to log into an account than go through getting hacked and (temporarily) losing $13,000, like I did <a href="https://www.vox.com/recode/2020/1/28/21080122/avoid-hack-hacker-theft">that time</a> hackers got into my bank account. You never know who has your password or how they got it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="et8Yqw">
“There’s an ongoing usability versus security thing where it’s not fun, it’s time-consuming, it’s annoying,” Grauer, of Consumer Reports, says.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5zbrtV">
It’s up to you to decide where the balance between usability and security should be, keeping in mind what you would lose if someone took over your accounts. After that, all you can do is try to keep these tips in mind, hope for the best, and don’t be too hard on yourself if you fall victim to the worst.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CGq8GY">
“Having a healthy paranoia, I think, is important,” Ostrowski says, before confessing that even he has slipped up and clicked on a few links he shouldn’t have. “I hate to admit it, but I think everybody has, right?”
</p></li>
<li><strong>Here’s why Netflix made you wait a month to watch the rest of Stranger Things</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/JU2jM1gAbTPDl2Kq-IIMTeGU084=/155x0:819x498/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71028024/StrangerThings_season_4_netflix_.0.jpeg"/>
<figcaption>
A scene from the fourth season of Netflix’s <em>Stranger Things</em>. | Netflix
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
One chart that tells you a lot about the state of the streaming service.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zDkHe9">
Netflix spends around $17 billion a year on new TV shows and movies. But its newest customers don’t think they’re getting their money’s worth: New data shows that Netflix subscribers are more likely to bail on the subscription service in the first month than are subscribers of any of its streaming competitors.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hYB5Zw">
That’s a new development, and it syncs with Netflix’s stunning news this spring that <a href="https://www.vox.com/recode/23032705/netflix-subscriber-loss-streaming-wars">it lost 200,000 subscribers in the first three months</a> of the year, and expects to lose another 2 million in the second quarter of the year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xFgtsD">
Those are the first subscriber losses the company has posted in a decade, and the results have led to a huge drop in its stock price, a scramble to find answers, and a <a href="https://www.vox.com/recode/23149037/netflix-streaming-hollywood-chill-peter-kafka">fair degree of schadenfreude</a>.
</p>
<aside id="BrPpui">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dEyGCj">
The data that suggests what kind of problem Netflix is facing comes to Recode via <a href="https://www.antenna.live/our-story">Antenna</a>, a research service that tracks consumer spending on subscription services. And it shows that by the end of April, 23 percent of Americans who signed up for Netflix had dropped the service within a month. That’s more new subscriber cancellations than any other competitive service Antenna tracks — including the likes of Apple TV+ and HBO Max, which used to have higher early churn numbers but have recently improved them.
</p>
<figure class="e-image">
<img alt="Netflix subscribers are now more likely to quit in the first month than any other streaming service " src="https://cdn.vox-cdn.com/thumbor/HVLMMs-q-VhKXS2MbQNGhVxpIxo=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23657781/EYdXt_netflix_subscribers_are_now_more_likely_to_quit_in_the_first_month_than_any_other_streaming_service.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="P9eUX0">
Antenna says its data comes from a panel of 5 million American consumers; the numbers don’t include free trials, or bundles and special offers like the one Verizon and Disney have done in the past.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Rg02YT">
We still don’t know <em>why</em> Netflix subscribers are becoming Netflix cancelers, and there could be several reasons. It could be because of the company’s <a href="https://www.marketwatch.com/story/netflix-increasing-prices-standard-plan-to-top-15-a-month-stock-jumps-11642192358?mod=article_inline">newest price hike</a>, which went into effect early this year — at the same time that new subscribers began to churn out at a higher rate. It could be that after signing up to stream a specific new show or movie, customers looked around and couldn’t find other stuff they wanted to watch — or, at least pay for. It could be that they prefer Netflix rivals like Disney+ or HBOMax. Perhaps all of the above.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BntVcT">
But it’s certainly worrisome for Netflix, which used to offer subscribers a huge swath of Big Media’s best movies and TV shows, because Big Media wasn’t paying attention to streaming. That’s over now, and some of the best-performing stuff that used to be on Netflix — TV shows like <em>The Office</em> and <em>Friends</em>; movies like Disney’s Marvel franchise — are now on competitors’ platforms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gBQe6r">
So Netflix’s response includes a move to offer <a href="https://www.vox.com/recode/23065689/streaming-netflix-ads-tv-peter-kafka">a cheaper version of the service with ads</a>, and an admission that it has to get better at the programming it makes for itself.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="r2k9l5">
It also appears to be intentionally backtracking on its initial pledge to let viewers watch an entire season of a show at once. Instead, in the case of a few high-profile shows, like <em>Ozark</em>, it has released the newest season in two chunks, spaced months apart. It’s doing the same thing for the new season of <em>Stranger Things</em>: The first seven episodes came out on May 27, but the last two won’t come out until this Friday, July 1.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E5Zgxq">
That is: If you want to see all of <em>Stranger Things</em> season 4 right away, you need to subscribe to Netflix for at least two months, and likely for three. You can see the logic for that in the chart of Antenna data below, which tracks the churn of video subscribers who have signed up in the last three months. In this one, you can see that Netflix performs in the middle of the pack of its peers, which tend to release one new episode of a hit show every week. If Netflix can hang onto subscribers for a little bit, its relative performance improves.
</p>
<figure class="e-image">
<img alt="Netflix subscribers who signed up in the last 3 months are more likely to quit than in the past " src="https://cdn.vox-cdn.com/thumbor/OZyvaGesYvlmO0wsDf71HJVJ57s=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23657784/TQR6x_netflix_subscribers_who_signed_up_in_the_last_3_months_are_more_likely_to_quit_than_in_the_past.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dUGraW">
A Netflix rep declined to comment on Antenna’s data, but pointed me to the company’s commentary in its <a href="https://ir.netflix.net/investor-news-and-events/investor-events/event-details/2022/Netflix-First-Quarter-2022-Earnings-Interview/default.aspx">April earnings call</a>, where it acknowledged “slight elevated churn” — but also said that its ability to hang on to customers “remains at a very healthy level.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XcwlcU">
The best news for Netflix, which still has some 220 million subscribers — much more than any competitor — is that the longer someone subscribes to Netflix, the more likely they are to keep subscribing. The company’s lifetime churn rate remains better than anyone else — though it has gone up in recent months as well:
</p>
<figure class="e-image">
<img alt="Netflix’s overall subscriber base is more likely to quit than in the past — but less likely than the competition " src="https://cdn.vox-cdn.com/thumbor/GBDKT9BS9NfPmUZ9kmdUW_fq35Q=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23657789/FYZ3O_netflix_s_overall_subscriber_base_is_more_likely_to_quit_than_in_the_past_but_less_likely_than_the_competition.png"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g5naCh">
But hanging on to older subscribers won’t help Netflix that much if it can’t keep its new ones. And it needs new ones to keep investors at bay. Netflix was worth nearly $300 billion last fall; now it’s worth $84 billion, and that number could keep falling if Wall Street thinks its growth days are over. There’s no single magic bullet for that, and the task may get even tougher if a recession forces consumers to cut back on entertainment spending — and perhaps spend more time watching <a href="https://www.vox.com/recode/2022/6/22/23177051/tiktok-tv-streaming-peter-kafka-media">free entertainment options like TikTok</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9YNDtw">
<em>One of the reasons it’s fun to write about Netflix is that everyone’s a Netflix expert, because everyone uses Netflix. So: What are you seeing? Are you sticking with Netflix? Have you swapped it out for something else? If you’ve dropped it, what would you need to come back? Drop me a line at </em><a href="mailto:kafkaonmedia@recode.net"><em><strong>kafkaonmedia@recode.net</strong></em></a><em> and let me know. </em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="716w4x">
<em>And if you’re reading this on a browser but would like to have it delivered to your inbox, free of charge: Good news! Sign up </em><a href="https://link.vox.com/click/28128670.1102/aHR0cHM6Ly93d3cudm94LmNvbS9wYWdlcy9wZXRlci1rYWZrYS1tZWRpYS1uZXdzbGV0dGVyLXNpZ24tdXA/62975efa4d0fcc71df00a2a9D69b67925"><em>here</em></a><em> for piping hot content (almost) every Wednesday.</em>
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amreli, Ashwa Bravo, Ayr, Caracas, Siege Perilous, and Moon’s Blessing please</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Yay! Chennai’s popular Covelong Classic - Surf, Music and Fitness Festival is back, with a host of new attractions</strong> - It will take place at Surf Turf on ECR, between August 5 and 7</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>I took up boxing because society thought women were not strong enough to box: Nikhat Zareen</strong> - Nikhat Zareen sees familial support as a crucial part of any young athlete’s development</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Viswanathan Anand calls for more women chess players</strong> - Chess found a way to beat COVID-19 with online games, says five-time world champion Anand</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ligue 1 | Monaco signs Japanese forward Minamino from Liverpool</strong> - Takumi Minamino has signed a four-year contract with the Ligue 1 side after 2.5 years at Liverpool. Monaco has bought him for a fee of £15.5 million</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protest withdrawn</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra Pradesh: Somu Veerraju condemns attack on BJP leaders in Anantapur</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India slams U.N. Human Rights for comments on action against Teesta Setalvad, calls it ‘completely unwarranted’</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Executive MBA programme of IIM-K ranked third in country</strong> - Evaluation done at sixth edition of Quacquarelli Symonds global ranking</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Udaipur murder | Kanhaiya Lal had told cops some people were conducting recce of his shop</strong> - Neighbour Nazim had filed a case against him over a controversial social media post</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Nato summit: Turkey pushes Finland and Sweden on extradition after deal</strong> - It calls for the handover of 33 “terror” suspects after a deal to let Finland and Sweden join Nato.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Paris attacks: Survivors who found friendship in marathon terror trial</strong> - The 2015 Paris attacks left 130 people dead and some of the survivors have formed a unique bond.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war cluster munitions: ‘Everything began to explode’</strong> - A BBC investigation has gathered evidence of the repeated use of cluster munitions in the city of Chernihiv, northern Ukraine.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Putin’s cousin among inner circle hit by new UK sanctions</strong> - Sanctions against Anna Tsivileva will help weaken the Russian war machine, the UK’s foreign office says.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: CCTV shows civilians fleeing Russian missile strikes in Kremenchuk</strong> - Footage from a pond in Kremenchuk shows people running for cover as missile strikes hit nearby area.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Couple bought home in Seattle, then learned Comcast Internet would cost $27,000</strong> - City “has no authority to require Comcast” to connect unserved homes. - <a href="https://arstechnica.com/?p=1862620">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A wide range of routers are under attack by new, unusually sophisticated malware</strong> - Router-stalking ZuoRAT is likely the work of a sophisticated nation-state, researchers say. - <a href="https://arstechnica.com/?p=1863305">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sony finally announces a 4K monitor you might actually want</strong> - For the first time in almost 2 decades, Sony announced non-professional monitors. - <a href="https://arstechnica.com/?p=1863146">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Review: Razer Kishi V2 refines the “gamepad that clamps to phone” concept</strong> - But Kishi’s 2020 model will be better for some users, and Razer’s app still stinks. - <a href="https://arstechnica.com/?p=1863247">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NASA aims to launch the SLS rocket in just 2 months</strong> - “We made incredible progress last week.” - <a href="https://arstechnica.com/?p=1863306">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>Recently got a Vasectomy because I did not wish to have children</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
It didn’t work at all. Came home after the procedure and my son was still there
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/CartographerTricky83"> /u/CartographerTricky83 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vn525l/recently_got_a_vasectomy_because_i_did_not_wish/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vn525l/recently_got_a_vasectomy_because_i_did_not_wish/">[comments]</a></span></p></li>
<li><strong>A soviet joke about censorship that I found in my school book</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
An American tells a Russian that people in USA have the freedom of speech and that he even could go to the White House and shout:“Go to hell, Ronald Reagan!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The russian answers:“Oh, we also have freedom of speech. I, too, can go to Kremlin and shout:” Go to hell, Ronald Reagan!"
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/DS_TheOne"> /u/DS_TheOne </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vnckq2/a_soviet_joke_about_censorship_that_i_found_in_my/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vnckq2/a_soviet_joke_about_censorship_that_i_found_in_my/">[comments]</a></span></p></li>
<li><strong>Jesus walks into a restaurant and asks for a table for 23..</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Waitress says, “but there’s only 13 of you”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Jesus says, “yes but we all want to sit on 1 side”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
EDIT; supposed to be 26..
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/gg663"> /u/gg663 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vmtril/jesus_walks_into_a_restaurant_and_asks_for_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vmtril/jesus_walks_into_a_restaurant_and_asks_for_a/">[comments]</a></span></p></li>
<li><strong>How does sex change for a man before and after a vasectomy?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
There’s no vast difference.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
…it’s funnier out loud.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Edit: vas deferens/vast difference
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/FreyrFreyja"> /u/FreyrFreyja </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vmysq8/how_does_sex_change_for_a_man_before_and_after_a/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vmysq8/how_does_sex_change_for_a_man_before_and_after_a/">[comments]</a></span></p></li>
<li><strong>Dear son; Your mom and I love you very much, and we miss you dearly ever since you went to prison. I especially miss you now that spring is here, and it is time to plow the fields. The ground is hard, and my back is old. I am afraid I will never be able to plant the crops in time. Dad</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Dear Dad:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Do not dig in the field. That is where I hid that thing. You know I can not say what it is because they read our mail. Just do not dig out there.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Your son
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
—————————————-
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Dear son:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The cops came out and dug up my fields. They said they were looking for something. Thanks, son. It looks like I will get the crops planted.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Your loving and grateful father
</p>
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