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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>TinyM2Net: A Flexible System Algorithm Co-designed Multimodal Learning Framework for Tiny Devices</strong> -
<div>
With the emergence of Artificial Intelligence (AI), new attention has been given to implement AI algorithms on resource constrained tiny devices to expand the application domain of IoT. Multimodal Learning has recently become very popular with the classification task due to its impressive performance for both image and audio event classification. This paper presents - a flexible system algorithm co-designed multimodal learning framework for resource constrained tiny devices. The framework was designed to be evaluated on two different case-studies: COVID-19 detection from multimodal audio recordings and battle field object detection from multimodal images and audios. In order to compress the model to implement on tiny devices, substantial network architecture optimization and mixed precision quantization were performed (mixed 8-bit and 4-bit). shows that even a tiny multimodal learning model can improve the classification performance than that of any unimodal frameworks. The most compressed achieves 88.4% COVID-19 detection accuracy (14.5% improvement from unimodal base model) and 96.8% battle field object detection accuracy (3.9% improvement from unimodal base model). Finally, we test our models on a Raspberry Pi 4 to see how they perform when deployed to a resource constrained tiny device.
</div>
<div class="article- link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/e8px7/" target="_blank">TinyM2Net: A Flexible System Algorithm Co-designed Multimodal Learning Framework for Tiny Devices</a>
</div></li>
<li><strong>Protection of prior natural infection compared to mRNA vaccination against SARS-CoV-2 infection and severe COVID-19 in Qatar</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
BACKGROUND: Protection conferred by natural SARS-CoV-2 infection versus COVID-19 vaccination has not been investigated in rigorously controlled studies. We compared head-to-head protection conferred by natural infection to that from the BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccines in Qatar, between February 28, 2020 and March 6, 2022. METHODS: Two national matched retrospective target-trial cohort studies were conducted to compare incidence of SARS-CoV-2 infection and COVID-19 hospitalization and death among those with a documented primary infection to incidence among those with a two-dose primary-series vaccination. Associations were estimated using Cox proportional-hazards regression models. RESULTS: The overall adjusted hazard ratio (AHR) for infection was 0.46 (95% CI: 0.45-0.48) comparing those with a prior infection to those vaccinated with BNT162b2, and 0.51 (95% CI: 0.48-0.53) comparing those with a prior infection to those vaccinated with mRNA-1273. For BNT162b2, the AHR decreased gradually from 0.55 (95% CI: 0.46-0.65) in the fourth month after primary infection/vaccination to 0.31 (95% CI: 0.27-0.37) in the eighth month, while for mRNA-1273, it decreased from 0.80 (95% CI: 0.59-1.07) to 0.35 (95% CI: 0.29-0.41) over the same time period. During the Omicron wave, the AHR was ~0.50 for BNT162b2 and ~0.60 for mRNA-1273. The overall AHR for any severe, critical, or fatal COVID-19 (against all variants) was 0.32 (95% CI: 0.10-1.00) for BNT162b2, and 0.58 (95% CI: 0.14-2.43) for mRNA-1273. CONCLUSIONS: Natural infection was associated with stronger and more durable protection against infection, regardless of the variant, than mRNA primary-series vaccination. Nonetheless, vaccination remains the safest and optimal tool of protection against infection and COVID-19 hospitalization and death.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272529v1" target="_blank">Protection of prior natural infection compared to mRNA vaccination against SARS-CoV-2 infection and severe COVID-19 in Qatar</a>
</div></li>
<li><strong>A log-odds system for waning and boosting of COVID-19 vaccine effectiveness</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Immunity to SARS-CoV-2 following vaccination wanes over time in a non-linear fashion, making modelling of likely population impacts of COVID-19 policy options challenging. We observed that it was possible to mathematize non-linear waning of vaccine effectiveness (VE) on the percentage scale as linear waning on the log-odds scale, and developed a random effects logistic regression equation based on UK Health Security Agency data to model VE against Omicron following two and three doses of a COVID-19 vaccine. VE on the odds scale reduced by 47% per month for symptomatic infection after two vaccine doses, lessening to 35% per month for hospitalisation. Waning on the odds scale after triple dose vaccines was 35% per month for symptomatic disease and 19% for hospitalisation. This log-odds system for estimating waning and boosting of COVID-19 VE provides a simple solution that may be used to parametrize SARS-CoV-2 immunity over time parsimoniously in epidemiological models.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272519v1" target="_blank">A log-odds system for waning and boosting of COVID-19 vaccine effectiveness</a>
</div></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Monoclonal antibody and antiviral therapy for treatment of mild-to-moderate COVID-19 in pediatric patients</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The recent surge of SARS-CoV-2 Omicron variant (B.1.1.529) coincided with new treatment options for mild-to- moderate Covid-19 in high-risk adolescents and adults. In this report we describe patient characteristics, treatment- related process measures and outcomes associated with early Covid-19 therapy in high-risk pediatric patients.
</p>
</div></li>
</ul>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272511v1" target="_blank">Monoclonal antibody and antiviral therapy for treatment of mild-to-moderate COVID-19 in pediatric patients</a>
</div>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Founder effect contributes to the unique pattern of SARS-CoV-2 variant B.1.1.519 emergence in Alaska</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Alaska is the largest geographic state in the United States with the lowest population density and a mix of urban centers and isolated rural communities. The differences in population dynamics in Alaska from the contiguous United States may have contributed to a unique pattern of emergence and spread of SARS-CoV-2 variants observed in early</p></div></li>
</ul>
<ol start="2021" type="1">
<li>Here we examined 2,323 virus genomes from Alaska and 278,635 virus genomes from the contiguous United States collected between the first week of December 2020 through the last week of June 2021. We focused on this timeframe because of the notable emergence and spread of the SARS-CoV-2 lineage B.1.1.519 observed in Alaska. We found that this variant was consistently detected in Alaska from the end of January through June of 2021 with a peak prevalence in April of 77.9% unlike the rest of the United States with a peak prevalence of 4.6%. In Alaska, the earlier emergence of B.1.1.519 coincided with a later peak of Alpha (B.1.1.7) when compared to the rest of the United States. We also observed differences in the composition of lineages and variants over time between the two most populated regions of Alaska. Although there was a modest increase in COVID-19 cases during the peak incidence of B.1.1.519, it is difficult to disentangle how social dynamics conflated changes in COVID-19 during this time. We suggest that the viral characteristics, such as amino acid substitutions in the spike protein, and a founder effect likely contributed to the unique spread of B.1.1.519 in Alaska.
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"></p>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272446v1" target="_blank">Founder effect contributes to the unique pattern of SARS-CoV-2 variant B.1.1.519 emergence in Alaska</a>
</div></li>
</ol>
<ul>
<li><strong>An immune dysfunction score for stratification of patients with acute infection based on whole blood gene expression</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing millions of deaths globally each year. To alleviate this burden, improved prognostication and biomarkers of response are urgently needed. We investigated the use of whole blood transcriptomics for stratification of patients with severe infection by integrating data from 3,149 samples of sepsis patients and healthy individuals into a gene expression reference map. We used this map to derive a quantitative sepsis response signature (SRSq) score reflective of immune dysfunction and predictive of clinical outcomes, which can be estimated using a 19-gene signature. Finally, we built a machine learning framework, SepstratifieR, to deploy SRSq in sepsis, H1N1 influenza, and COVID-19, demonstrating clinically relevant stratification across diseases and revealing the physiological alterations linking immune dysregulation to mortality. Our method enables early identification of individuals with dysfunctional immune profiles, thus bringing us closer to precision medicine in infection.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272427v1" target="_blank">An immune dysfunction score for stratification of patients with acute infection based on whole blood gene expression</a>
</div></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Characteristics of mental health stability during COVID-19: An online survey with people residing in the Liverpool City Region</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background and aim : Despite the significant mental health challenges the COVID-19 pandemic and its associated government measures have presented, research have shown that the majority of people have adapted and coped well. The aim of this study was i) to determine the proportion of people with mental stability and volatility during the pandemic in a North West urban environment sample and ii) to establish group differences in psychosocial variables. Mental stability and volatility refer to the extent to which individuals reported change in levels of common mental health symptoms over the course of 12 weeks. Method : a two-wave-online survey (N = 163) was used to explore the psychological and social impact of the pandemic on relatively disadvantaged neighbourhoods within the Liverpool City Region over 12 weeks. Kruskal-Wallis with post-hoc tests were used to determine how people with mental stability and volatility differed on factors categorised within an ecological framework of resilience (individual, community, societal, and COVID-19 specific). Results : Individuals categorised as stable in terms of mental health symptoms (63.6%) had better mental and physical health; were more tolerant of uncertainty; reported higher levels of resilience and wellbeing compared to very volatile people (19.8%). These individuals also reported feeling less socially isolated, experienced a greater sense of belonging to their community which was more likely to fulfil their needs, and were more likely to have access to green space nearby for their recommended daily exercise. Stable individuals did not report worrying any more during the pandemic than usual and tolerated uncertainty better compared to those in the volatile group. Implications : The majority of participants in this sample were mentally stable and coping well with the challenges presented by the pandemic. The resilience of these individuals was related to key place-based factors such as a strong sense of community and useable local assets. The data showcase the role of place-based social determinants in supporting resilience and thereby highlight key preventative measures for public mental health during times of international crisis.
</p>
</div></li>
</ul>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272479v1" target="_blank">Characteristics of mental health stability during COVID-19: An online survey with people residing in the Liverpool City Region</a>
</div>
<ul>
<li><strong>Effectiveness of whole virus COVID-19 vaccine at protecting health care personnel against SARS-CoV-2 infections in Lima, Peru</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In February 2021, Peru launched a vaccination campaign among healthcare personnel using BBIBP-CorV inactivated whole virus (BBIBP-CorV) COVID-19 vaccine. Two doses of BBIBP-CorV vaccine are recommended, 21 days apart. Data on BBIBP-CorV vaccine effectiveness will inform the use and acceptance of vaccination with BBIBP-CorV vaccine. We evaluated BBIBP-CorV vaccine effectiveness among an existing multi-year influenza cohort at two hospitals in Lima. We analyzed data on 290 participants followed between February and May 2021. Participants completed a baseline questionnaire and provided weekly self-collected anterior nasal swabs tested for SARS-CoV-2 by rRT-PCR for sixteen weeks. We performed multivariable logistic regression models adjusting for pre-selected characteristics (age, sex, exposure to COVID-19 patients, work in intensive care unit or emergency department, BMI, and exposure time in days). BBIBP-CorV vaccine effectiveness was calculated after the two-week post-vaccination period as (1-Odds Ratio for testing SARS-CoV-2 positive)x100%. SARS-CoV-2 was detected by rRT-PCR among 25 (9%) participants during follow-up (February-May 2021). Follow-up period ranged 1-11 weeks (median: 2 weeks). Among cohort participants who were fully vaccinated the adjusted vaccine effectiveness against SARS-CoV-2 infection was estimated as 95% (95% CI: 70%, 99%) and 100% (95% CI: 88%, 100%) for those partially vaccinated. During the study period, vaccination of healthcare personnel with BBIBP-CorV vaccine was effective at reducing SARS-CoV-2 infections in the weeks immediately following vaccination. This information can be used to support vaccination efforts in the region, especially among those who could be concerned about their effectiveness.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22271100v1" target="_blank">Effectiveness of whole virus COVID-19 vaccine at protecting health care personnel against SARS-CoV-2 infections in Lima, Peru</a>
</div></li>
<li><strong>Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background Acute COVID-19 clinical symptoms have been clearly documented, but long-term functional and symptomatic recovery from COVID -19 is less well described. Methods A systematic review and meta-analysis were conducted to describe patient-reported outcome measures (PROMs) in adults at least 8 weeks post hospital discharge for COVID-19. Comprehensive database searches in accordance with the PRISMA statement were carried out up till 31/05/2021. Data were narratively synthesized, and a series of meta-analyses were performed using the random-effects inverse variance method. Results From 49 studies, across 14 countries with between 2-12 months follow up, the most common persisting symptom reported was fatigue with meta-analysis finding 36.6% (95 % CI 27.6 to 46.6, n=14) reporting it at 2-4 months, decreasing slightly to 32.5% still reporting it at &gt;4 months (95% CI 22.6 to 44.2, n=15). This was followed by dyspnoea. Modified MRC score (mMRC) ≥1 was reported in 48% (95% CI 30 to 37, n=5) at 2-4months reducing to 32% (95% CI 22 to 43, n=7) at 4 months. Quality of life (QOL) as assessed by the EQ-5D-5L VAS remained reduced at &gt;4 months (73.6 95% CI 68.1 to 79.1, n=6). Hospitalisation with COVID-19 also resulted in persisting sick leave, change in scope of work, and continued use of primary and secondary healthcare. Conclusion The symptomatic and functional impact of COVID-19 continues to be felt by patients months after discharge from hospital. This widespread morbidity points towards a multi-disciplinary approach to aid functional recovery.
</p>
</div>
<div class="article-link article- html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272509v1" target="_blank">Patient-reported respiratory outcome measures in the recovery of adults hospitalised with COVID-19: A systematic review and meta-analysis</a>
</div></li>
<li><strong>Mobility was a Significant Determinant of Reported COVID-19 Incidence During the Omicron Surge in the Most Populous U.S. Counties</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
We studied the relationship between declines in mobility and subsequently reported COVID-19 case incidence in 111 of the most populous U.S. counties during the Omicron surge from December 2021 through February 2022. We employed principal component analysis to construct a one-dimensional summary measure of the six Google mobility categories that are regularly reported for each county. Among counties with a lower mobility decline between December 20 and January 3, reported COVID-19 incidence did not peak until the week ending January 17, whereas among counties with a higher mobility decline, incidence peaked earlier by the week ending January 10 and remained significantly lower. Based upon a fixed- effects, longitudinal cohort model, we estimated that every 1-percent decline in mobility between December 20 and January 3 was associated with a 0.63 percent decline in peak incidence during the week ending January 17 (95% confidence interval, 0.40-0.86 percent). Based upon a cross-sectional analysis including mean household size and vaccination participation as covariates, we estimated that the same 1-percent decline in mobility was associated with a 0.36 percent decline in cumulative reported COVID-19 incidence from January 10 through February 28 (95% CI, 0.18-0.54 percent). Omicron did not simply sweep through the U.S. population until it ran out of susceptible individuals to infect. To the contrary, a significant fraction managed to avoid infection by engaging in risk-mitigating behaviors. More broadly, the behavioral response to perceived risk should be viewed as an intrinsic component of the natural course of epidemics in humans.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272523v1" target="_blank">Mobility was a Significant Determinant of Reported COVID-19 Incidence During the Omicron Surge in the Most Populous U.S. Counties</a>
</div></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Selection of appropriate reference genes for normalization of qRT-PCR based gene expression analysis in SARS-CoV-2, and Covid-associated Mucormycosis infection</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Selection of reference genes in quantitative PCR is critical to determine accurate and reliable mRNA expression. Despite this knowledge, not a single study has investigated the expression stability of housekeeping genes to determine their suitability to act as reference gene in SARS-CoV-2 or Covid19 associated mucormycosis (CAM) infections. Herein, we address these gaps by investigating the expression stability of nine most commonly used housekeeping genes including TBP, CypA, B2M, 18S, PGC-1α, GUSB, HPRT-1, β-ACTIN and GAPDH in the patients of varying severity (asymptomatic, mild, moderate and severe). We observed significant differences in the expression of candidate genes across the disease spectrum. Next, using various statistical algorithms (delta Ct, Normfinder, Bestkeeper, RefFinder and GeNorm), we observed that CypA demonstrated the most consistent expression across the patients of varying severity and emerged as the most suitable gene in Covid19, and CAM infections. Incidentally, the most commonly used reference gene GAPDH showed maximum variations and found to be the least suitable. Lastly, comparative evaluation of expression of NRF2 is performed following normalization with GAPDH and CypA to highlight the relevance of an appropriate reference gene. Our results reinforce the idea of a selection of housekeeping genes only after validation especially during infections.
</p>
</div></li>
</ul>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.15.22272441v1" target="_blank">Selection of appropriate reference genes for normalization of qRT-PCR based gene expression analysis in SARS-CoV-2, and Covid-associated Mucormycosis infection</a>
</div>
<ul>
<li><strong>Survey of nationwide public perceptions regarding acceptance of wastewater used for community health monitoring in the United States</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
During the coronavirus disease 2019 (COVID-19) pandemic researchers looked for evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in feces dissolved in wastewater samples to assess levels of infection across communities. This activity is known colloquially as sewer monitoring and called wastewater-based epidemiology in academic settings. When used for public health surveillance in the United States, wastewater monitoring is not regulated, although general ethical principles have been described. Prior to this study, no nationwide data existed regarding the public9s perceptions of wastewater being used for community health monitoring. Using an online survey distributed to a representative sample of adults in the Unites States (N=3,083), we investigated the public9s perceptions regarding what is monitored, where monitoring occurs, and privacy concerns related to wastewater monitoring as a public health surveillance tool. Further, the Privacy Attitudes Questionnaire assessed respondents9 general privacy boundaries. The results suggest that respondents supported using wastewater for health monitoring, but within some bounds. Participants were most likely to support or strongly support monitoring for disease (95%), environmental toxins (94%), and terroristic threats (90%, e.g., anthrax). Two-thirds of respondents endorsed no prohibition to locations being monitored while the most common category of location respondents wanted to be prohibited from monitoring was personal residencies. Additionally, the findings suggest that those younger in age and living in an urban area were more supportive of wastewater monitoring, compared to older, suburban dwellers.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272262v1" target="_blank">Survey of nationwide public perceptions regarding acceptance of wastewater used for community health monitoring in the United States</a>
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<li><strong>COVID-19 Disease Model with Reservoir of Infection : Cleaning Surfaces and Wearing Masks Strategies</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
At the end of 2019 a new coronavirus (called SARS-COV-2) epidemic appears in china and spreads from China to the rest of the world at beginning of 2020 and caused a new disease called COVID-19. It9s well known that, COVID-19 disease spreads between humans through the air by coughing and sneezing or by contact. In this paper, we develop a mathematical SIR model which takes into account the effect of disease transmission by coughing and sneezing and the period of latency which is represented by time delays. We prove that, there is non effect of latency period on the dynamics of the propagation and transmission of the coronavirus, and for some critical value of the basic reproduction number a transcritical bifurcation may occur and the disease disappears for values smaller than this critical value and persist otherwise. In the end, we carry out some numerical simulations in order to illustrate our theoretical results. Our study confirm that, cleaning surfaces and wearing masks is a controlling strategy for limiting the propagation of COVID-19.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.16.22272508v1" target="_blank">COVID-19 Disease Model with Reservoir of Infection : Cleaning Surfaces and Wearing Masks Strategies</a>
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<li><strong>SARS-CoV-2 virus dynamics in recently infected people - data from a household transmission study</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
We used daily real-time reverse-transcription polymerase chain reaction (rRT-PCR) results from 67 cases of SARS- CoV-2 infection in a household transmission study to examine the trajectory of cycle threshold (Ct) values, an inverse correlate of viral RNA concentration, from nasal specimens collected between April 2020 and May 2021. Ct values varied over the course of infection, across RT-PCR platforms, and by participant age. Specimens collected from children and adolescents showed higher Ct values and adults aged ≥50 years showed lower Ct values than adults aged 18-49 years. Ct values were lower on days when participants reported experiencing symptoms.
</p>
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<div class="article-link article- html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.17.22272516v1" target="_blank">SARS-CoV-2 virus dynamics in recently infected people - data from a household transmission study</a>
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<li><strong>Large-scale analysis of SARS-CoV-2 synonymous mutations reveals the adaptation to the human codon usage during the virus evolution</strong> -
<div>
Many large national and transnational studies have been dedicated to the analysis of SARS-CoV-2 genome, most of which focused on missense and nonsense mutations. However, approximately 30% of the SARS-CoV-2 variants are synonymous, therefore changing the target codon without affecting the corresponding protein sequence. By performing a large-scale analysis of sequencing data generated from almost 400,000 SARS-CoV-2 samples, we show that silent mutations increasing the similarity of viral codons to the human ones tend to fixate in the viral genome over-time. This indicates that SARS- CoV-2 codon usage is adapting to the human host, likely improving its effectiveness in using the human aminoacyl-tRNA set through the accumulation of deceitfully neutral silent mutations.
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<div class="article-link article-html- link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.04.23.441151v2" target="_blank">Large- scale analysis of SARS-CoV-2 synonymous mutations reveals the adaptation to the human codon usage during the virus evolution</a>
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<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Bronchipret on Antiviral Immune Response in Patients With Mild COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Bronchipret<br/><b>Sponsors</b>:   Dr. Frank Behrens;   Bionorica SE<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating Public Health Interventions to Improve COVID-19 Testing Among Underserved Populations</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Behavioral: Public Health Intervention Package<br/><b>Sponsors</b>:   Kathleen Fairfield;   MaineHealth<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Serologic Strategies for Skilled Nursing Facilities</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Cohorting<br/><b>Sponsors</b>:   NYU Langone Health;   Brown University;   National Institute on Aging (NIA)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety, Tolerability and Immunogenicity of Recombinant COVID-19 Vaccine Betuvax-CoV-2</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Betuvax-CoV-2;   Drug: Placebo<br/><b>Sponsors</b>:   Human Stem Cell Institute, Russia;   Betuvax LLC;   CEG BIO LLC<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Community-based Study of Spikogen®, a Protein-subunit Covid-19 Vaccine</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: Advax-CpG55.2 adjuvanted recombinant spike protein<br/><b>Sponsors</b>:   Professor Nikolai Petrovsky;   Australian Respiratory and Sleep Medicine Institute;   Tasmanian Eye Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Volumetric Quantification on Computer Tomography Using Computer Aided Diagnostics</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Diagnostic Test: CAD analysis<br/><b>Sponsors</b>:  <br/>
Bogdan Bercean;   Pius Brinzeu Timisoara County Emergency Hospital<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults</strong> - <b>Condition</b>:   Post COVID-19<br/><b>Intervention</b>:   Other: Evaluation of Pulmonary and Extrapulmonary Impacts of COVID-19 on Young Adults<br/><b>Sponsor</b>:   Istanbul Arel University<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Early High-Titre Convalescent Plasma in Clinically Vulnerable Individuals With Mild COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: COVID-19 convalescent and vaccinated plasma;   Other: Current standard of care<br/><b>Sponsors</b>:   Centre Hospitalier Universitaire de Besancon;   Deutsches Rotes Kreuz DRK-Blutspendedienst Baden-Wurttemberg-Hessen;   NHS Blood and Transplant<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy of TCM Capsules Lian Hua Qing Wen Jiao Nang in Mild COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Other: TCM intervention;   Other: Placebo intervention<br/><b>Sponsor</b>:   Singapore Chung Hwa Medical Institution<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trial to Study the Efficacy and Safety of BEJO Red Ginger in COVID-19 Patients With Mild Symptoms</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Dietary Supplement: BEJO Red Ginger Extract;   Other: Placebo<br/><b>Sponsors</b>:   Research Center for Chemistry, National Research and Innovation Agency of Indonesia;   National Research and Innovation Agency of Indonesia;   RSDC Wisma Atlet;   PT. Bintang Toedjoe<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Pharmacokinetics of FBR-002 for the Treatment of Patients Hospitalized With COVID-19 in Need of Supplemental Oxygen and at Risk of Severe Outcome</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: FBR-002;   Drug: Placebo<br/><b>Sponsor</b>:  <br/>
Fabentech<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">**Safety and Immune Response of Adjuvanted SARS-CoV-2 (COVID-19) Beta Variant RBD Recombinant Protein (DoCo-Pro-RBD-1</li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">MF59®) and mRNA (MIPSCo-mRNA-RBD-1) Vaccines in Healthy Adults** - <b>Condition</b>:   SARS-CoV-2<br/><b>Interventions</b>:   Biological: Adjuvanted SARS-CoV-2 beta variant RBD recombinant protein vaccine (DoCo-Pro-RBD-1 + MF59);   Biological: SARS-CoV-2 beta variant RBD mRNA vaccine;   Other: Normal Saline<br/><b>Sponsors</b>:   University of Melbourne;   Southern Star Research<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>PROSPECTIVE OPEN LABEL CLINICAL TRIAL TO ADMINISTER A BOOSTER DOSE OF PFIZER/BIONTECH OR MODERNA COVID-19 VACCINE IN HIGH-RISK INDIVIDUALS</strong> - <b>Conditions</b>:   SARS CoV 2 Infection;   COVID-19<br/><b>Interventions</b>:  <br/>
Biological: Pfizer/BioNTech (BNT162b2);   Biological: Moderna<br/><b>Sponsor</b>:  <br/>
DHR Health Institute for Research and Development<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Self-Management Interventions for Long-COVID</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Behavioral: Education and Strategies Intervention;   Behavioral: Mindfulness Skills Intervention<br/><b>Sponsors</b>:   Toronto Rehabilitation Institute;   Canadian Institutes of Health Research (CIHR);   University Health Network, Toronto<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Hyper Coagulability Care by LLLT</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Radiation: Low level laser Therapy;   Other: Circulatory exercises<br/><b>Sponsor</b>:   Cairo University<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Soluble uric acid inhibits beta2 integrin-mediated neutrophil recruitment in innate immunity</strong> - Neutrophils are key players during host defense and sterile inflammation. Neutrophil dysfunction is a characteristic feature of the acquired immunodeficiency during kidney disease. We speculated that the impaired renal clearance of the intrinsic purine metabolite soluble uric acid (sUA) may account for neutrophil dysfunction. Indeed, hyperuricemia (HU, serum UA of 9-12 mg/dL) related or unrelated to kidney dysfunction significantly diminished neutrophil adhesion and extravasation in mice with…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells</strong> - Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. In the present study, we show that type 1 interferon (IFN-I) regulates coinhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting TIGIT expression. High-temporal-resolution mRNA profiling of IFN-I responses established the dynamic regulatory networks uncovering three temporal transcriptional…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules, as well as the virus per se, remain elusive. Here we report a role of RNA G-quadruplex (RG4) in SARS-CoV-2 infection. Combining bioinformatics, biochemical and biophysical assays, we demonstrate the presence of RG4s in both SARS-CoV-2 genome…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevity</strong> - Ferulic acid, a bacterial metabolite of anthocyanins, seems likely to be a primary mediator of the health benefits associated with anthocyanin-rich diets, and has long been employed in Chinese cardiovascular medicine. In rodent studies, it has exerted wide-ranging antioxidant and anti-inflammatory effects, the molecular basis of which remains rather obscure. However, recent studies indicate that physiologically relevant concentrations of ferulic acid can boost expression of Sirt1 at mRNA and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impact of COVID-19 on college student diet quality and physical activity</strong> - Background: The COVID-19 pandemic can cause in increase in stress experienced by college students and consequently, potentially adversely affect their health behaviours. Aims: The aim of this study was to investigate how COVID-19 impacted college-attending young adults diet quality and physical activity. Methods: Students attending an Appalachian university in spring 2020 participated in this cross-sectional study. Participants were surveyed on their eating habits, diet quality, and physical…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Overview of clinical outcome and therapeutic effectiveness of Favipiravir in patients with COVID-19 admitted to intensive care unit, Riyadh, Saudi Arabia</strong> - CONCLUSION: According to the studys results revealing FVP is not superior to other antivirals, patients who received Favipiravir presented with more severe symptoms, more comorbidities, more complications, and is not effective in controlling the cytokine storm which negatively impact the efficacy of Favipiravir. FVP therapy had no influence on ICU and hospital length of stay in comparison with the control group as well as in the overall mortality rate among the FVP group was not statistically…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jumping From Fragment To Drug Via Smart Scaffolds</strong> - A focused drug repurposing approach is described where an FDA-approved drug is rationally selected for biological testing based on structural similarities to a fragment compound found to bind a target protein by an NMR screen. The approach is demonstrated by first screening a curated fragment library using 19F NMR to discover a quality binder to ACE2, the human receptor required for entry and infection by the SARS-CoV-2 virus. Based on this binder, a highly related scaffold was derived and used…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intersected discrimination through the lens of COVID-19: The case example of Christian minority in Iraq</strong> - Compelling evidence proved that coronavirus disease (COVID-19) disproportionately affects minorities. The goal of the present study was to explore the effects of intersected discrimination and discrimination types on COVID-19, mental health, and cognition. A sample of 542 Iraqis, 55.7% females, age ranged from 18 to 73, with (M = 31.16, SD = 9.77). 48.7% were Muslims, and 51.3% were Christians (N = 278). We used measures for COVID-19 stressors, executive functions, intersected discrimination…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection</strong> - C-type lectin domain-containing proteins (CTLDcps) shape host responses to pathogens and infectious disease outcomes. Previously, we identified the murine CTLDcp Cd302 as restriction factor, limiting hepatitis C virus (HCV) infection of murine hepatocytes. In this study, we investigated in detail the human orthologues ability to restrict HCV infection in human liver cells. CD302 overexpression in Huh-7.5 cells potently inhibited infection of diverse HCV chimeras representing seven genotypes….</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Flipped inflammatory time and the role of antibodies against SARS-CoV-2: optimising tocilizumab against COVID-19</strong> - No abstract</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Blocking viral infections with lysine-based polymeric nanostructures: a critical review</strong> - The outbreak of the Covid-19 pandemic due to the SARS-CoV-2 coronavirus has accelerated the search for innovative antivirals with possibly broad-spectrum efficacy. One of the possible strategies is to inhibit the replication of the virus by preventing or limiting its entry into the cells. Nanomaterials derived from lysine, an essential amino acid capable of forming homopeptides of different shapes and sizes through thermal polymerization, are an exciting antiviral option. In this review, we have…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Peramivir, an Anti-Influenza Virus Drug, Exhibits Potential Anti-Cytokine Storm Effects</strong> - Coronavirus Disease 2019 (COVID-19) infected by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a public health emergency of international concerns. Cytokine storm syndrome (CSS) is a critical clinical symptom of severe COVID-19 patients, and the macrophage is recognized as the direct host cell of SARS-CoV-2 and potential drivers of CSS. In the present study, peramivir was identified to reduce TNF-α by partly intervention of NF-κB activity in LPS-induced macrophage…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Allosteric Site of ACE-2 as a Drug Target for COVID-19</strong> - The coronavirus disease 2019 (COVID-19) pandemic has a significant impact on healthcare systems and our lives. Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provide protection against SARS-CoV-2. However, mutations in the viral genome are common, raising concerns about the effectiveness of existing vaccines for SARS-CoV-2. The receptor-binding domain (RBD) of SARS-CoV-2 uses angiotensin-converting enzyme-2 (ACE-2) as a gateway to enter host cells. Therefore, the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Case Report: Tackling Complement Hyperactivation With Eculizumab in Atypical Hemolytic Uremic Syndrome Triggered by COVID-19</strong> - Hemolytic uremic syndrome (HUS) is a rare life-threatening disease of unrestrained complement system dysregulation, microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure in genetically predisposed individuals. In this report, we describe two cases of SARS-CoV-2-associated HUS treated with eculizumab, a C5-blocking monoclonal antibody reported to be remarkably effective in the treatment of HUS. Detailed biochemical and genetic complement system analysis is reported, and the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry</strong> - Coagulopathy is a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin. While certain host proteases, including TMPRSS2 and furin, are known to be important for cleavage activation of SARS-CoV-2 spike to promote viral entry in the respiratory tract, other proteases may also contribute. Using biochemical and cell-based assays, we demonstrate that factor Xa and thrombin can also directly cleave…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>MACHINE LEARNING TECHNIQUE TO ANALYZE THE WORK PRESSURE OF PARAMEDICAL STAFF DURING COVID 19</strong> - Machine learning technique to analyse the work pressure of paramedical staff during covid 19 is the proposed invention that focuses on identifying the stress levels of paramedical staff. The invention focuses on analysing the level of stress that is induced on the paramedical staff especially during pandemic. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN353347401">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CBD Covid 19 Protection</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU353359094">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD AND SYSTEM FOR IMPLEMENTING IMPROVED GENERALIZED FUZZY PEER GROUP WITH MODIFIED TRILATERAL FILTER TO REMOVE MIXED IMPULSE AND ADAPTIVE WHITE GAUSSIAN NOISE FROM COLOR IMAGES</strong> - ABSTRACTMETHOD AND SYSTEM FOR IMPLEMENTING IMPROVED GENERALIZED FUZZY PEER GROUP WITH MODIFIED TRILATERAL FILTER TO REMOVE MIXED IMPULSE AND ADAPTIVE WHITE GAUSSIAN NOISE FROM COLOR IMAGESThe present invention provides a new approach is proposed that includes fuzzy-based approach and similarity function for filtering the mixed noise. In a peer group, the similarity function was adaptive to edge information and local noise level, which was utilized for detecting the similarity among pixels. In addition, a new filtering method Modified Trilateral Filter (MTF) with Improved Generalized Fuzzy Peer Group (IGFPG) is proposed to remove mixed impulse and Adaptive White Gaussian Noise from Color Images. The modified trilateral filter includes Kikuchi algorithm and loopy belief propagation to solve the inference issues on the basis of passing local message. In this research work, the images were collected from KODAK dataset and a few real time multimedia images like Lena were also used for testing the effectiveness of the proposed methodology. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN351884428">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A STUDY ON MENTAL HEALTH, STRESS AND ANXIETY AMONG COLLEGE STUDENTS DURING COVID-19</strong> - SARS-Cov-2 virus causes an infectious disease coronavirus(COVID-19).The Students life is made harder by COVID-19.The human reaction that happens normally to everyone through physical or emotional tension is stress. Feeling of angry, nervous and frustration caused through any thought or events leads to stress. As college closures and cancelled events, students are missing out on some of the biggest moments of their young lives as well as everyday moments like chatting with friend, participating in class and cultural programme. For students facing life changes due to the outbreak are feeling anxious, isolated and disappointed which lead them to feel all alone. We like to take the help of expert adolescent psychologist to find out the techniques to practice self-care and look after their mental health. We would like to find out whether techniques used reduce the anxiety and stress among Engineering Students. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN351884923">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A METHOD FOR THE TREATMENT OF COVID-19 INFECTIONS WITH PALMITOYLETHANOLAMIDE</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU351870997">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CONNECTING A TUTOR WITH A STUDENT</strong> - A system and a method for connecting a tutor with a student in real time. Initially, the system receives a student profile. Further, the system receives a question from the student. Furthermore, the system synthesizes the question based on a set of predefined machine learning model. Subsequently, the system determines a cohort of the students from the set of the cohort of the students. The cohort of the students is determined based on the one or more parameters related to the question. Further, the system identifies a tutor assigned to the cohort of the students. Subsequently, the system notifies the tutor in real time. Further, the system receives an acknowledgement from the tutor within a predefined time. Finally, the system connects the tutor with the student in real time when the acknowledgement is the positive acknowledgement. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN352550208">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A CENTRAL TRANSACTION AUTHENTIC SYSTEM FOR OTP VERIFICATION</strong> - The present invention relates to a central transaction authentic system (100) for OTP verification. The system (100) comprises one or more user display units (102), one or more financial units (104), an account deposit unit (106), an OTP authentication unit (108) and a service server unit (110). The central transaction authentic system (100) for OTP verification work as Anti-money laundering measure. The system (100) also helpful for minimizing rate of cybercrime. The central transaction authentic system (100) for OTP verification that can neutralize digital financial fraud. The present invention provides a central transaction authentic system (100) for OTP verification that can monitor and analyze every transaction and customer interaction across its customer base for suspicious and potentially criminal activity. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN350377210">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FORMULATIONS AND METHOD FOR PREPARATION OF HERBAL MEDICATED TRANSPARENT SOAP</strong> - ABSTRACTFORMULATIONS AND METHOD FOR PREPARATION OF HERBAL MEDICATED TRANSPARENT SOAPThe present invention provides formulations for herbal medicated transparent soaps and method of preparation of the same. Transparent soaps are prepared by saponification of mixture of non-edible oils to get the desired consistency and cleaning action. Nonvolatile alcohols and other transparency promoters are used to get good transparency and binding properties. Herbal extracts of different herbs are added to get medicated properties. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN350377796">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>POOL CAMPUS PLACEMENT INTERACTIVE APP FOR INDUSTRY ACADEMIA</strong> - In recent days students complete the studies through online and find difficult in getting placement. Since the COVID has stopped the Industries/Companies to conduct campus interview and direct recruitment throughout India. This leads to huge unemployment and companies lack in finding the correct person for their job. To overcome this issue it is proposed to develop an application where recruiters can easily conduct their recruitment process. This app integrates the students database and the Industry/company database. This model helps the recruiter to choose the eligible student from the huge database instead of a group of students from a particular University/college. There are many benefits like faster recruitment process, many students finding their dream job, HR process the interview from the remote location, entire process is in online, no need to travel and accommodate a place for rent. The entire process is recorded and saved as a report, this ensures 100 % genuine and no space for malpractice. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN352549250">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SOCIAL NAVIGATION SYSTEM FOR MOBILE ROBOTS IN THE EMERGENCY DEPARTMENT TECHNOLOGY</strong> - The emergency department (ED) is a safety-critical environment in which healthcare workers (HCWs) are overburdened, overworked, and have limited resources, especially during the COVID-19 pandemic. One way to address this problem is to explore the use of robots that can support clinical teams, e.g., to deliver materials or restock supplies. However, due to EDs being overcrowded, and the cognitive overload HCWs experience, robots need to understand various levels of patient acuity so they avoid disrupting care delivery. In this invention, we introduce the Safety-Critical Deep Q-Network (SafeDQN) system, a new acuity-aware navigation system for mobile robots. SafeDQN is based on two insights about care in EDs: high-acuity patients tend to have more HCWs in attendance and those HCWs tend to move more quickly. We compared SafeDQN to three classic navigation methods, and show that it generates the safest, quickest path for mobile robots when navigating in a simulated ED environment. We hope this work encourages future exploration of social robots that work in safety-critical, human-centered environments, and ultimately help to improve patient outcomes and save lives. Figure 1. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN349443355">link</a></p></li>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>In a World on Fire, Stop Burning Things</strong> - The truth is new and counterintuitive: we have the technology necessary to rapidly ditch fossil fuels. - <a href="https://www.newyorker.com/news/essay/in-a-world-on-fire-stop-burning-things">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jerome Powells Double Message on Inflation</strong> - The Fed raised interest rates for the first time since 2018, but its chair insists the move wont deliver a serious hit to the wider economy. - <a href="https://www.newyorker.com/news/our-columnists/jerome-powells-double-message-on-inflation">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Zelensky Invokes Pearl Harbor and 9/11 as He Pleads for More from Washington</strong> - The U.S. sent more than a billion dollars in aid in the past week. But Biden has refused Ukraines two biggest requests. - <a href="https://www.newyorker.com/news/daily-comment/zelensky-invokes-pearl-harbor-and-911-as-he-pleads-for-more-from-%20washington">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Have iPhone Cameras Become Too Smart?</strong> - Apples newest smartphone models use machine learning to make every image look professionally taken. That doesnt mean the photos are good. - <a href="https://www.newyorker.com/culture/infinite-scroll/have-iphone-cameras-become-too-smart">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraines Radio Station of National Resistance</strong> - High up in the Carpathian Mountains, two Kyiv broadcasters keep the signal alive. - <a href="https://www.newyorker.com/news/dispatch/ukraines-radio-station-of-national-resistance">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>How you can help all refugees — from Ukraine and beyond</strong> -
<figure>
<img alt="" src="https://cdn.vox-
cdn.com/thumbor/kmanu1sjiXezPPq4e8SqTEr5KHw=/0x0:1821x1366/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70645309/GettyImages_1239026071_copy.0.jpg"/>
<figcaption>
A defense lawyer, who escaped Afghanistan when the Taliban seized power, takes refuge in Athens, Greece. | Loulou DAki/Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Lets move past the myth of the “deserving” refugee to ease global suffering.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2df9QS">
The war in <a href="https://www.vox.com/russia-invasion-ukraine">Ukraine</a> has captured the worlds attention, and thats as it should be. The devastation is <a href="https://www.vox.com/22970918/russia-war-
in-ukraine-explained">tragic</a>, and its been heartening to see governments and ordinary citizens taking a real interest in Ukrainian refugees and <a href="https://www.vox.com/future-perfect/22955885/donate-ukraine">giving</a> generously to help them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LqF001">
At the same time, we have to ask ourselves why we arent just as attentive and altruistic toward other refugees around the world in circumstances that are just as desperate. Many of us are donating time, money, and even <a href="https://www.vox.com/22973133/ukraine-russia-airbnb-booking-donate-effective-
altruism">Airbnbs</a> to help Ukrainians — but how many of us have done the same for refugees from <a href="https://www.reuters.com/world/us-resume-iraqi-refugee-program-after-fraud-investigation-2022-03-02/">Iraq</a>? <a href="https://www.refugeecouncil.org.au/myanmar-burma/">Myanmar</a>? <a href="https://www.unrefugees.org/emergencies/south-sudan/">South Sudan</a>? <a href="https://www.unrefugees.org/emergencies/yemen/#:~:text=In%20the%20first%20half%20of,under%20the%20age%20of%2018.">Yemen</a>?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bYZC9k">
“Theres been a lot of attention and compassion for Ukrainian refugees and its a stark contrast with other groups,” said Lamis Abdelaaty, a political scientist at Syracuse University who researches why the world treats some refugees better than others. “First of all, it has to do with the identity of the people who are fleeing from Ukraine. Theyre seen as white and Christian. People tend to sympathize with refugees who they think share their identity.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="63medz">
You may have seen discrimination on the basis of race and religion worming its way into media reports. Take, for example, NBC News correspondent Kelly Cobiella, who <a href="https://www.middleeasteye.net/news/russia-ukraine-war-criticised-racism-western-coverage">said</a> that “these are not refugees from Syria, these are refugees from Ukraine. … Theyre Christian, theyre white, theyre very similar.”
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-
cdn.com/thumbor/Z5hpwDZU2J7AT15st7KtA7KgS-A=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23326874/GettyImages_1238841584_copy.jpg"/> <cite>Beata Zawrzel/NurPhoto via Getty Images</cite>
<figcaption>
People who arrived on a train from Ukraine stand in line to buy tickets at a railway station in Poland on February 28, 2022.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="x0YH75">
Or take CBSs senior correspondent Charlie DAgata, who <a href="https://twitter.com/imraansiddiqi/status/1497607326487826435">said</a> in Kyiv that “this isnt a place, with all due respect, like Iraq or Afghanistan. … This is a relatively civilized, relatively European — I have to choose those words carefully, too — city where you wouldnt expect that.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MCQDj1">
Foreign policy is also a salient factor, as is justified moral outrage over the invasion of one country by another. “It matters that Ukrainians are fleeing an invasion by Russia,” Abdelaaty said. “Being especially attuned to them and welcoming them is a powerful way to condemn this aggression … to send a signal that you are on the side of democracy.” Governments as well as ordinary citizens have a chance to position themselves in a satisfying narrative: aligned with the Hero, fighting against the clear Bad Guy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QNruQp">
Nevertheless, Abdelaaty told me, “My hope is that this crisis will lead people to think deeply about why they empathize with certain people over others, and lead people to recognize that all refugees are equally deserving of our compassion.”
</p>
<h3 id="oEKF7A">
The myth of the “deserving” refugee
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2Apcoi">
The number of forcibly displaced people in the world is at a record high — <a href="https://www.unrefugees.org/refugee-
facts/statistics/#:~:text=Global%20Trends%20At%2Da%2DGlance&amp;text=26.6%20million%20refugees%20in%20the,4.4%20million%20asylum%2Dseekers.">84 million</a> by last years count, more than the entire population of Germany, and more than double what the number was a decade ago. Theyre fleeing their homes for reasons ranging from human rights violations (<a href="https://www.hrw.org/news/2021/09/09/whats-next-afghans-fleeing-taliban">like in Afghanistan</a>) to famines and floods spurred by climate change (<a href="https://reliefweb.int/report/south-sudan/unhcr-concerned-climate-change-
impacts-south-sudan">like in South Sudan</a>).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jZMiBx">
But depending on who these displaced people are and where theyre coming from, the world tends to look at them very differently.
</p>
<figure class="e-image"></figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><img alt="The charts show the funding gaps of the top UNHCR situations, and the highest displaced population by
nationality" src="https://cdn.vox-cdn.com/thumbor/ScIB0UzZO4e9zfmOwgFsW_AeEi0=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23327715/idp_mid2021_by_country2.jpg"/> <cite>Youyou Zhou/Vox</cite></p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HJPGiB">
“Theres a dichotomy that tends to be drawn between the deserving refugee and the undeserving migrant,” Abdelaaty said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3RbCpQ">
Under the 1951 Refugee Convention, ratified when the world was still dealing with millions of people displaced during World War II, a refugee is someone fleeing persecution thats targeted to them as an individual based on their race, religion, or political opinions. Most Ukrainians actually wouldnt qualify for refugee status, because theyre fleeing generalized violence, rather than being specifically targeted for one of those criteria, Abdelaaaty explained.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BFm4Mh">
Yet governments and the media were quick to label them refugees — in stark contrast to the reaction in 2015, when there was a <a href="https://www.cnn.com/2022/03/16/middleeast/mideast-summary-03-16-2022-intl/index.html">lot of hand-wringing</a> about whether to call the people arriving in Europe “refugees” or “migrants.” The use of the term “migrants” to describe Syrians likely had a <a href="https://www.unhcr.org/56bb369c9.pdf">negative impact</a> <a href="https://journals.sagepub.com/doi/10.1177/2056305118785638">on public opinion</a> about them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D7XQqf">
Even now, Middle Easterners coming to Europe suffer from a double standard. Nowhere is this clearer today than in Poland. On that countrys border with Ukraine, Ukrainians are being welcomed with open arms. Meanwhile, on Polands border with Belarus, Syrians, Iraqis, and Afghans <a href="https://www.hrw.org/report/2021/11/24/die-here-or-
go-poland/belarus-and-polands-shared-responsibility-border-abuses">have been</a> <a href="https://www.theguardian.com/global-development/commentisfree/2022/mar/04/embraced-or-pushed-back-on-the-polish-
border-sadly-not-all-refugees-are-welcome">forcefully kept out</a>; Poland is even building a <a href="https://www.aljazeera.com/news/2022/1/25/poland-begins-work-on-400m-belarus-border-wall-against-migrants">$400 million wall</a> to repel them.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-
cdn.com/thumbor/WUkRmFZzBWZA0h8MYyHLjMHAgoM=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23326881/GettyImages_1234777759_copy_1.jpg"/> <cite>Wojtek Radwanski/AFP via Getty Images</cite>
<figcaption>
Afghans were left stranded on the border between Belarus and Poland in 2021.
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Vn0ZT6">
“The fact that Ukrainians are being labeled refugees means, for many people, that they are deserving, because theyre being forced to move. Whereas in the popular parlance, people who are migrants are choosing to move and therefore theyre not deserving of our compassion,” Abdelaaty said. “But I would urge people to consider whether people who are moving because theyre fleeing crushing poverty or the effects of climate change are any less deserving of our compassion. Id argue no.”
</p>
<h3 id="mimWS0">
How you can help refugees effectively
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qBHw6V">
All refugees need support, and most refugee crises <a href="https://reporting.unhcr.org/sites/default/files/Underfunding-Report-2021.pdf">are underfunded</a> — especially those that have fallen out of the media spotlight or never captured it to begin with.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="edfFZu">
Before the war in Ukraine, <a href="https://www.unhcr.org/refugee-statistics/">85 percent</a> of the worlds refugees lived in low- and middle-income countries, often in far greater numbers than in rich countries. Turkey, for example, still hosts 3.6 million Syrian refugees. (The US, by contrast, <a href="https://www.migrationpolicy.org/article/refugees-and-asylees-
united-states-2021?gclid=Cj0KCQjwuMuRBhCJARIsAHXdnqNMmGrJrGlwuWo-
SgqjRNoTjagOh821YEw2B3BVv4xuZmL8c-hM36YaAuifEALw_wcB">settled fewer than 12,000 refugees</a> altogether in fiscal year 2020.) These countries often dont have the resources to support their own people, let alone millions of newcomers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3OMKXK">
Thats why Helen Dempster, an assistant director at the Center for Global Development, says, “Countries neighboring Ukraine, such as Poland, definitely do require support, though I would argue not as much support as those low- and middle-income countries that have been hosting refugees for years or decades.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Csvgqr">
UNHCR, the UN Refugee Agency, provides an annual list of the most financially neglected crises. Heres the most recent list:
</p>
<figure class="e-image">
<img alt="The charts show the funding gaps of the top UNHCR situations, and the
highest displaced population by nationality" src="https://cdn.vox-
cdn.com/thumbor/eXy-2fHvHAi3XJEnbmjYFFzPljk=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23327714/funding_gap_unhcr3.jpg"/> <cite>Youyou Zhou/Vox</cite>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vScWSH">
So how can you help people in these crises?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HKWb37">
First of all, you can donate to organizations that are doing effective, transparent, and accountable work. Abdelaaty and Dempster recommended several options:
</p>
<ul>
<li id="j8GpzD">
If you want to support refugees and host communities on the ground, you can donate to organizations like the <a href="https://www.rescue.org/">International Rescue Committee</a>, <a href="https://donate.unhcr.org/int/en/general-v2">UNHCR</a>, <a href="https://www.oxfam.org/en">Oxfam</a>, and <a href="https://www.doctorswithoutborders.org/">Doctors Without Borders</a>. Its best if you give an unrestricted donation, allowing your money to be used where and when its most needed.
</li>
<li id="qlgxtE">
If you really want to support people in a specific crisis, you can donate cash directly to affected people through <a href="https://www.givedirectly.org/refugees/">GiveDirectly</a> or to vetted local organizations through <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.globalgiving.org_search_-3Fsize-3D25-26nextPage-3D1-26sortField-3Dsortorder-26selectedThemes-3Drefugee-26loadAllResults-3Dtrue&amp;d=DwMGaQ&amp;c=7MSjEE-
cVgLCRHxk1P5PWg&amp;r=kV_pE3Fk2uPZQgQK0cNHqCollNEYBT3dTA9DKAIWwEw&amp;m=4HKzQ5v0QTU6T9yN_NxKaMUc2JFrFeJN0i-n2ews3s6XK6iLn8PnPM6yh2ZKDpZj&amp;s=ctRKm3y-E_yRRWIhQ1txgpcSoscAX4lHz__Jrzt_HW8&amp;e=">GlobalGiving</a>. (Disclosure: I donated to GiveDirectly in 2021.)
</li>
<li id="GsYCjU">
If you want to support systemic policy change that will benefit refugee populations, you can donate to nonprofits with a strong track record of achieving results. A prime example is the <a href="https://refugeerights.org/">International Refugee Assistance Project</a>, which advocates for reforms to the US resettlement program while also providing legal aid to displaced people around the world.
</li>
<li id="SaJkPM">
If you want to support refugees once theyve already arrived in your country, you can donate to your <a href="https://www.acf.hhs.gov/orr/map/find-resources-and-contacts-your-state">local resettlement agency</a>, which gives refugees short-term support to help them rebuild their lives in their new community.
</li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YwD2cw">
Beyond donations, you can play an important role by pressuring your government to provide enough aid for people on the ground — and to be receptive to newcomers who are arriving at your countrys borders. If youre in the US, for example, here are concrete things you can do:
</p>
<ul>
<li id="9985bn">
You can contact your representatives to tell the Biden administration to <a href="https://www.raicestexas.org/2022/03/16/tell-the-biden-administration-end-mpp-and-
title-42/">end Title 42</a>, a Trump-era policy blocking displaced people from Central America, Haiti, and around the world from accessing their right to apply for asylum.
</li>
<li id="bkYgUa">
You can contact your representatives to <a href="https://vfai.quorum.us/campaign/38432/">tell them to pass the Afghan Adjustment Act</a> to give evacuated Afghans permanent legal status in the US.
</li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WM649f">
Finally, you can volunteer your time and energy to help refugees settle into their new lives.
</p>
<ul>
<li id="ZobPF5">
You can <a href="https://www.vox.com/future-
perfect/22883775/afghan-refugee-private-sponsorship">sponsor an Afghan refugee family</a> in your community.
</li>
<li id="4mEHWK">
You can <a href="https://rcusa.org/get-involved/volunteer/">volunteer</a> with your <a href="https://www.acf.hhs.gov/orr/map/find-resources-and-contacts-your-state">local resettlement agency</a>, helping with everything from furnishing a refugee familys new apartment to enrolling children in school.
</li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SvN2zQ">
In the US, the official resettlement infrastructure was <a href="https://www.vox.com/policy-and-
politics/22422368/biden-refugee-cap-resettlement">decimated under the Trump administration</a>, and it still hasnt recovered; the Biden administration has arguably been too slow undoing the damage. A huge backlog of refugees need to have their applications processed and then be integrated into new communities. Investing in rebuilding the refugee resettlement infrastructure is a key step to addressing the backlog thats preventing thousands of people from restarting their lives in the US.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7MaCpL">
At the end of the day, donating, advocating, or volunteering in any of the ways listed above is a valuable way to make a difference. Refugees need immediate support when theyre fleeing a nightmare on the ground; they need advocates to shape welcoming policies at their destinations; and they need assistance settling in when they reach their new homes. All of these roles are important.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qxtMHv">
So if the heart-wrenching war in Ukraine has strengthened your desire to reduce the suffering of refugees, its worth trying to expand the circle of compassion to include refugees beyond Ukraine, and get to work helping them, too.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3Pj7sb">
<em>A version of this story was initially published in the Future Perfect newsletter. </em><a href="https://confirmsubscription.com/h/d/A2BA26698741513A"><em><strong>Sign up here to subscribe!</strong></em></a>
</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZJFhR8">
</p>
<ul>
<li><strong>Standup comedy and the myth of cancel culture</strong> -
<figure>
<img alt="A man with a bushy gray beard wears a ball cap and plaid shirt while smiling for the camera." src="https://cdn.vox-cdn.com/thumbor/ouuOpkZYo3xj0DJ5K1wzxDMUzLo=/167x0:2834x2000/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70645220/GettyImages_1146598526.0.jpg"/>
<figcaption>
David Cross at the 2019 Tribeca Film Festival in New York City. | Roy Rochlin/Getty Images for Tribeca Film Festival
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
David Cross on political humor, how standup has changed, and why complaints about cancellation are “bullshit.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5GF7ZO">
What do we want from comedians?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZhuYnN">
We want them to be funny. We want them to turn outrage into laughter. We want them to look at the absurdity of the world and reflect back on it in some kind of cathartic way. We also want them to “punch up,” to mock the powerful. And then sometimes we just want them to get us to stop thinking and laugh.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rofrVs">
<a href="https://www.vox.com/culture/22922007/comedy-isnt-funny-moral-
joe-rogan-whitney-cummings-moses-storm-che-diaz">The role of comedy</a> is always an open question, but it seems to pop up a lot these days. Comics like <a href="https://www.thedailybeast.com/michael-che-claims-he-doesnt-want-any-trouble-
his-new-netflix-special-says-otherwise">Michael Che</a> and <a href="https://www.nytimes.com/2021/10/25/business/media/dave-chappelle-netflix.html">Dave Chappelle</a> have been in the news, for different reasons, and its usually about free speech or “cancel culture.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FxFHEz">
Most of these debates are boring and circular, but I am interested in how comics engage with the world, and what they decide to make fun of and why. So I reached out to David Cross for the latest episode of <a href="https://podcasts.apple.com/us/podcast/vox-conversations/id1081584611"><em>Vox Conversations</em></a>. You probably know him from his TV work. He was the star and co-creator of HBOs <em>Mr. Show</em> and he famously played Tobias Funke on the cult hit <em>Arrested Development</em>. But hes also a long-time standup comedian and has a new special out, called <a href="https://officialdavidcross.com/"><em>Im From the Future</em>.</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ezZb9r">
We talk about the evolution of his comedy, why he doesnt think of himself as a political comedian, and what he thinks about “cancel culture” and the idea of “selling out.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Dq1Zc9">
Below is an excerpt, edited for length and clarity. As always, theres much more in the full podcast, so subscribe to <em>Vox Conversations</em> on <a href="https://apps.apple.com/us/app/vox-conversations/id1215557536">Apple Podcasts</a>, <a href="https://podcasts.google.com/search/vox%20conversations">Google Podcasts</a>, <a href="https://open.spotify.com/show/6NOJ6IkTb2GWMj1RpmtnxP">Spotify</a>, <a href="https://www.stitcher.com/show/vox-
conversations">Stitcher</a>, or wherever you listen to podcasts.
</p>
<div id="bo2SS5">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZX097r">
</p>
<hr class="p-entry-hr" id="AiUAN1"/>
<h4 id="5UgpXd">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t8omQ2">
This is one of those moments where I feel like everyones pissed off about everything, and you definitely seem as pissed off as the rest of us in this special. Did you feel like you had an unusual amount of rage bottled up for this one?
</p>
<h4 id="cGmxQK">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BK9pKC">
Id say it was normal rage. Its always there. The question is always what am I directing it toward? But everything is tempered now because Im a dad and so I try to infuse some sort of optimism in all the anger and negativity and cynicism because I just have to for my kids sake.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DaBdO3">
But I dont know if its rage, exactly. Its mostly incredulousness. Its just the frustration of looking at a world that makes no sense. And youre twisting everything to make it make sense to you and it just doesnt on so many levels. And thats part of where the anger stems from, I guess. We could have a truly great society, but you guys keep fucking it up.
</p>
<h4 id="YdWTxl">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HzMZAx">
My favorite bit in the show is where youre pretending to stand in front of all these imaginary kids and youre telling them all the ridiculous shit theyll organize their political identities around when theyre older, all the inane stuff theyll be pissed off about.
</p>
<h4 id="kDnw8s">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qs1dft">
Yeah, thats where the title of the show comes from, <em>Im From the Future</em>. Thats a good example of a bit where I had a very vague idea of doing something about people who scream at other people in a store for speaking Spanish. They overhear them speaking Spanish and they scream at them. I worked on that for months and I could not find the angle at all, and it just wasnt working. It sounded preachy.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="taOqoj">
And then it occurred to me, “Oh, what if they were 5 or 6 years old and you showed them the person that they were going to become?” The kids would be like, “No, I dont want to do that.” So thats where that whole thing came from.
</p>
<div class="c-float-right">
<aside id="7wyBio">
<q>“I dont know anybody thats not able to do standup anymore because they said something offensive”</q>
</aside>
</div>
<h4 id="jZcEKc">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w8C0y1">
Its funny, when I started preparing for this interview, I thought about the distinction between a political comic and a comic who just talks about politics, and I said to myself, “Of course, Cross is a political comic!” Then I heard you say that youre absolutely not a political comic, and naturally I felt like a jackass.
</p>
<h4 id="e5KEdE">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="seBzgZ">
Well, its not dumb. Ill let you finish your thought, but Ill just say that I can point to different comedians that are political comedians, and the bulk of their material, lets say more than 75 percent of it, deals directly with politics or cultural wedge issues, which might feel like its political, and mine doesnt.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AwrQH6">
I truly understand why sometimes it feels like more of the set is political, and my last few shows have been a little weightier and not as light and breezy as some of the others. I still have some really stupid dad puns, some bad jokes, and some silly impressions and absurdist stuff in there, but when youre doing material about Trump or Obama or even going all the way back to Bush, it feels like it has more weight to it.
</p>
<h4 id="fYc0BH">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BbcNxK">
I dont want to dump on any other comics, but there are some who Im not sure theyd have anything to talk about if they werent talking about politics, and I definitely dont think of you that way. There are the late-night-style comics who use politics as fodder, but theyre not really saying anything — its all discardable blooper stuff. And then there are comics who obviously are funny and tell jokes but theres a moral clarity behind it, and Ive always thought of you in that way, even though theres plenty of silliness in your material.
</p>
<h4 id="Jx5B5X">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AuERCk">
I didnt take it as an insult or anything, and Im not bothered by the idea that Im pigeonholed that way. Its just one of those things where I feel like I have to clarify things because I definitely talk about politics and I definitely have a strong point of view. But I still dont think of myself as a “political comedian.”
</p>
<h4 id="83FRls">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="itKCmv">
Do you talk about politics because you feel like you have to?
</p>
<h4 id="ZuovXz">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g3RP4d">
Not at all. I find that a little pretentious for my taste, the idea that I have a moral obligation to do this thing. And it also implies that I have some sort of galaxy brain that I have to share with people so that theyre enlightened. This is the kind of stuff Id be saying over a few pints at a bar with friends. And when these shows develop, I start at small rooms, like 99-seat rooms in a basement in a club in Brooklyn. So they are my friends. Theyre all right there in front of me. Thats where this stuff develops.
</p>
<h4 id="SBYV7X">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5ogPjQ">
I guess its the ideological comics that dont really work for me. I think you can be a funny political comedian, but Im not sure you can be a funny ideologue. I think you stop being funny when you stop telling the truth and its hard to tell the truth and serve an ideological audience at the same time.
</p>
<h4 id="ty1aTi">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pjtJyI">
I think youve hit on something, whether intentional or not, and it has to do with the polarization and the capitalization and the exploitation of our audiences. And I think you see a lot more people doing that kind of thing. Theyre speaking to a consumer base and theyre looking at it like that. It used to be, back in the late 80s or the early 90s, that there was a kind of stigma around the comics who were just doing standup so that they could get on a sitcom. That was a real thing. Other comics would recognize it immediately.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T3yzyo">
And now there are people who are trying to backdoor into standup via other avenues<strong> </strong>so you can get a podcast or something because thats where the money is. Its a 180 from where it used to be. People are getting into standup now for the money. So you get a lot of people with a foot in both worlds that are using standup specifically to build their base, to build their revenue-streaming possibilities.
</p>
<div class="c-float-right">
<aside id="f4d9iz">
<q>“We could have a truly great society, but you guys keep fucking it up”</q>
</aside>
</div>
<h4 id="qY5PPi">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m3duW0">
It really does feel like comedy has changed so much over the last 20 years, going back to the Bush era and up until today. You put out this <a href="https://www.amazon.com/Shut-Up-You-Fucking-
Baby/dp/B00006YXH0">amazing comedy album</a> shortly after 9/11 and it was one of the first pieces of popular art in those early days that anticipated the horrors of that era, and it seems like things have just gotten steadily darker since.
</p>
<h4 id="lX8Y9L">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Xs1PpX">
Its both a continuation and a heightening of more of the same thing. But I look back, I havent listened to that album, <a href="https://www.amazon.com/Shut-Up-You-Fucking-
Baby/dp/B00006YXH0"><em>Shut Up, You Fucking Baby!</em></a>, in quite a while. But thats a younger guy. Thats a guy who didnt know that things were going to remain awful and actually get worse and worse and worse. That was a guy in his 30s who has the world in front of him and who kind of knew what it was going to be like.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gtdq0z">
I had just moved to New York, maybe eight months prior to that, after being in LA for nine years, where every minute was spent like, “I got to get out of here.” And all the material that has developed subsequently is just a standup getting older and more outraged. But as I said earlier, Ive got to filter things and be as optimistic as I can because of my daughter and her friends. Im around kids a lot more now. I wasnt around kids a lot, certainly not back then. And so its interesting because Im just a different person now. Im the same standup, but my experiences are different. My world is different.
</p>
<h4 id="lMCRwv">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vSXE64">
Have you noticed a shift in the audience over the years?
</p>
<h4 id="oRX2k6">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rjPqQz">
Yeah, theyre older! They used to be in their 20s and 30s, now theyre in their 50s. Whats going on?
</p>
<h4 id="4bHqCO">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OtN0e1">
I just turned 40, man, I think Im one of the olds now. But seriously, do you feel like things have changed on the demand side in terms of where the lines are or what people will laugh at? Theres so much noise about “cancel culture” in comedy and I find most of it boring and I assume comics have always adapted with the times. Do you feel like the pace of adaptation is quicker now than maybe it was when you first started?
</p>
<h4 id="Wh3fUm">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lQAC8J">
I dont think so. Nobodys getting arrested.
</p>
<h4 id="UVjDvJ">
Sean Illing
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FjRTyi">
I dont actually know of any comedians whove been “canceled.”
</p>
<h4 id="zzDpJZ">
David Cross
</h4>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tVIIXw">
No, they havent been. Thats bullshit. If we think about it in less histrionic terminology, theres certainly a reality now where if you say something and if you dont apologize and you double down and then you triple down, then youre going to have a segment of your fan base react. And youre going to have lots of people who didnt care about you in the first place doing that whole performative outrage thing. Theyre just showing their weight as consumers. Its not that different from people saying, “Were going to boycott this thing because they advertise on Tucker Carlson and I dont like what he said.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sH4mAg">
People have every right to do that. We live in a capitalist society, and thats how it works. So people arent getting canceled. Theyre either getting their tickets refunded or trying to shame people from going to see somebodys live show. Who knows what kind of effect thatll have? Probably not very much.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zrWc3r">
I dont know anybody thats not able to do standup anymore because they said something offensive. Obviously, there are people who have done some egregious things that have nothing to do with their comedy and lots of people have made their feelings known about that. But if you say something extremely homophobic or misogynist or racist or anti-Semitic that cannot be defended and people go, “Hey that persons appearing on Apple TV or Netflix or whatever. Lets boycott the sponsors,” then thats their right. But nobodys not able to do standup. Maybe you cant sell out Madison Square Garden eight shows in a row, but youre still going to get to do standup.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6MU1JV">
<em>To hear the rest of the conversation, </em><a href="https://open.spotify.com/episode/4Airr42IpUiPY2ff2Ait4Q?si=96_q6kRjTK6jtI9ugNb-Aw"><em>click here</em></a><em>, and be sure to subscribe to </em>Vox Conversations<em> on </em><a href="https://apps.apple.com/us/app/vox-
conversations/id1215557536"><em>Apple Podcasts</em></a><em>, </em><a href="https://podcasts.google.com/search/vox%20conversations"><em>Google Podcasts</em></a><em>, </em><a href="https://open.spotify.com/show/6NOJ6IkTb2GWMj1RpmtnxP"><em>Spotify</em></a><em>, </em><a href="https://www.stitcher.com/show/vox-conversations"><em>Stitcher</em></a><em>, or wherever you listen to podcasts.</em>
</p></li>
<li><strong>Europes embrace of Ukrainian refugees, explained in six charts and one map</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/5NSJD-
ik84HXpEq36iRGcwSGQz0=/407x0:4766x3269/1310x983/cdn.vox-
cdn.com/uploads/chorus_image/image/70645260/GettyImages_1239264643_copy.0.jpg"/>
<figcaption>
Ukrainians wait to be registered by French immigration workers at a refugee welcome center in Paris on March 17. | Alain Jocard/AFP via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Data shows why Ukrainian refugees are being treated differently than others fleeing violence.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WnQz8a">
More than <a href="https://data2.unhcr.org/en/situations/ukraine">3 million people</a> have fled Ukraine in the weeks since the start of Russias invasion. Europe hasnt seen an <a href="https://www.vox.com/22954721/ukraine-refugee-poland-moldova-europe">exodus of this scale and speed</a> since World War II. Equally unprecedented is the welcoming attitude that countries neighboring Ukraine have had toward these refugees.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="G421qU">
Race, culture, and religion certainly play a role in the warm welcome fleeing Ukrainians have received. But recent history is another factor. Though Ukraine isnt part of the European Union, the ease with which Ukrainians have been able to work and travel to EU countries have made them fixtures in the bloc, and that — perhaps even more than geography — has contributed to a sense that they are Europeans currently in need of aid from other Europeans.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xSHh0h">
In the weeks since the start of the invasion, all of Ukraines borders except those with Russia and Belarus have remained open. Most refugees used one of the 31 border checkpoints in western Ukraine and entered Poland, Slovakia, Hungary, Romania, and Moldova. Poland took the majority, <a href="https://data2.unhcr.org/en/situations/ukraine">close to 2 million as of March 18</a>.
</p>
<div class="c-wide- block">
<figure class="e-image">
<img alt="The map shows the escape routes for people fleeing the Ukraine
crisis. It includes 31 border checkpoints to neighboring countries, and six humanitarian corridors." src="https://cdn.vox-cdn.com/thumbor/F9L7fB2UIh7cRQS7EDWQFnOMN3U=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23328541/Ukrainian_refugee_escape_routes.jpg"/>
</figure>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7rKrI8">
The governments of these nations — and non-governmental groups — quickly worked out emergency plans to help those fleeing the Russian invasion. The EU announced on March 4 that Ukrainian citizens (who, pre-war, didnt need a visa to stay up to 90 days in the EU territory) would be entitled to the newly enacted <a href="https://eur-lex.europa.eu/legal-
content/EN/TXT/PDF/?uri=CELEX:32022D0382&amp;from=EN">temporary protection directive</a> —permitting them to live, work, and study in EU member states for up to three years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fGpvrH">
The exact implementation may differ from country to country, and some plans may still shift. For the five neighboring countries that opened borders to let Ukrainians in, all except Moldova are EU members.
</p>
<figure class="e-image">
<img alt="The emergency
measures toward refugees from Ukraine by recipient countries" src="https://cdn.vox-
cdn.com/thumbor/9kp5UI9ETpczcru5p0yiraoDU1k=/800x0/filters:no_upscale()/cdn.vox-
cdn.com/uploads/chorus_asset/file/23328538/policy_by_recipient_countries_Ukrainian_refugee.jpg"/>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zDfty6">
Non-Ukrainians, however, didnt get the same rights or legal protection. In the first few days of Russias invasion, there were incidents in which Ukrainian citizens were allowed to cross the border while <a href="https://twitter.com/OliverGMarsden/status/1497672106439430145">non-Ukrainians faced obstacles to doing so</a>. Now, at least on paper, people can cross the border regardless of nationality. Poland issues a 15-day temporary permit, Romania a 90-day transit visa, and Hungary a 30-day residence permit to non-Ukrainians. Officials expect them to go back to their home countries before those permits expire, or apply for asylum if they wish to stay longer.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QliLvR">
The disparity between how Ukrainian and non-Ukrainian refugees are being treated is stark. It brings to the fore longstanding debates about what makes someone European, and who is worthy of Europes protection. Its also key to understanding why Ukrainians have been met with open arms by the rest of Europe.
</p>
<h3 id="58PqBF">
Why refugees from Ukraine have been treated differently
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="q5rmXl">
European countries havent seen such a large number of displaced people in this short period of time in recent history. It took three weeks for 3 million to leave Ukraine. While at least <a href="https://www.washingtonpost.com/world/2022/03/13/ukrainians-return-russia-war/">a couple hundred thousand Ukrainians have returned home</a>, thats still an overwhelmingly fast flow of people. When 3 million Syrians fled their country due to the war, it took <a href="https://data2.unhcr.org/en/situations/syria">two years to reach that milestone</a>, and an even longer time for Syrian refugees to reach Europe.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HG11YJ">
To put the size of the population fleeing Ukraine into perspective, nearly 6 million people applied for asylum in European Union countries from 2013 to 2021. About 2.5 million sought asylum during 2015 and 2016.
</p>
<div id="wNkxa8">
<div id="datawrapper-
Lbu6x">
</div></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="c9FK4x">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xCbFl0">
Syrian refugees saw a very different reception than the Ukrainians currently fleeing Russias assault have — one thats more reminiscent of the welcome non-Ukrainians have received, and consistent with the experiences other refugees of color have faced when trying to reach Europe. Hungarian Prime Minister Viktor Orbán called arriving migrants fleeing the Syrian war <a href="https://www.cbc.ca/radio/ideas/how-
the-hungarian-border-fence-remains-a-political-symbol-1.5476964">a Muslim invasion</a> in 2015 and built border walls to fence them off. Last October, Poland entered <a href="https://www.cnn.com/2021/10/10/europe/poland-belarus-border-
crossing-migrants-record-number-intl/index.html">a state of emergency</a> when thousands of refugees from Afghanistan and Iraq attempted to cross the border from Belarus into the European Union.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kzeqOS">
Polls across the EU reflect a deep wariness about certain immigrants. Generally, European countries are less welcoming to immigrants of races and ethnicities that differ from their predominantly white populations. And people in eastern European countries, including Slovakia, Hungary, and Poland, are less likely to think immigrants should be allowed in than their western counterparts, according to <a href="https://www.europeansocialsurvey.org/docs/findings/ESS7_toplines_issue_7_immigration.pdf">the latest European Social Survey</a>, conducted across the bloc in 2018.
</p>
<div id="51cMov">
<div id="datawrapper-3JYnQ">
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6dpvVe">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="u8ZhkS">
A push to repatriate refugees has led to efforts like Denmark working to send its <a href="https://www.nytimes.com/2022/03/07/world/europe/denmark-syrian-refugees.html">Syrian refugees from Damascus back home</a>. Across Europe, far-right parties have <a href="https://www.theguardian.com/world/2020/mar/02/immigration-
attitudes-have-barely-changed-why-far-right-on-rise">expanded their power</a>, both in individual nations and the EU parliament, partially on an anti-immigration platform.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sDTd2r">
The different treatment toward Ukrainian refugees is rooted in a sense that, although Ukraine isnt in the EU, its citizens are European.<strong> </strong>People from European countries see themselves in the Ukrainian refugees fleeing the war. That has been clear from their public statements, including those tinged with racist and xenophobic ideas about what it means to be European.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YS3SRE">
“These people are Europeans,” Bulgarian Prime Minister Kiril Petkov <a href="https://www.cbc.ca/news/world/europe-racism-ukraine-refugees-1.6367932">said</a>. “These people are intelligent. They are educated people. … This is not the refugee wave we have been used to, people we were not sure about their identity, people with unclear pasts, who could have been even terrorists.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ORWxlv">
While refugees from Middle Eastern, African, or Asian countries are seen as “others,” the geographic proximity, similar skin colors and religions, as well as the social-economic ties to the EU states all contribute to the identification of Ukrainians as “us” — Europeans.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ja5Knt">
An increasingly unified European identity has formed among the eastern European countries that joined the EU in the 2000s. Most citizens of Poland, Hungary, Slovakia, and Romania see themselves as citizens of the European Union.
</p>
<div>
<div id="Q6cq4S">
<div id="datawrapper-S9D1X">
</div>
</div>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YaxD5A">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UFcHBW">
While Ukrainians arent EU citizens, they have enjoyed visa-free travel in the EU member states since 2017. By 2020, they were the third-largest group of non-EU citizens living in the bloc, behind citizens of Morocco and Turkey.
</p>
<div id="esuATg">
<div id="datawrapper-ZcvHo">
</div>
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</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vnDJUQ">
Before the war, most Ukrainians in the EU came for work. More than half of Ukrainian migrants residing in the EU got their residence permits through work. In 2020, <a href="https://ec.europa.eu/eurostat/statistics-
explained/index.php?title=Residence_permits_-
_statistics_on_first_permits_issued_during_the_year&amp;oldid=507019#First_residence_permits_by_reason">86 percent of the Ukrainians</a> who applied for residence permits for the first time received their permits for employment-related reasons, the highest among all other nationals.
</p>
<div id="1w8T6H">
<div id="datawrapper-7GfC8">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vPbapi">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S8iKOD">
Ultimately, Ukrainians <a href="https://www.iri.org/resources/iri-ukraine-poll-shows-
support-for-eu-nato-membership-concerns-over-economy-and-vaccines-for-covid-19/">want their country to join the EU</a>. Four days into the war, Ukraines President Volodymyr Zelenskyy <a href="https://www.washingtonpost.com/politics/2022/03/09/ukraine-eu-membership/">submitted an application</a> for EU membership, an act then mirrored by former Soviet states Moldova and Georgia. The EU application and linkage processes take a long time, and western members of the bloc have rebuffed Ukraines request to fast-track its approval. But after years of roadblocks, the path is “<a href="https://www.theguardian.com/world/2022/mar/10/western-europe-leaders-rebuff-
ukraine-fast-track-eu-membership-appeal">open for them to take</a>.”
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2022 | We have got a title winning squad, now need to execute skills under pressure: Punjab Kings captain Mayank Agarwal</strong> - After four seasons with the team, Agarwal has been given the leadership responsibility</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sri Lanka to host Asia Cup T20 tournament from Aug 27 to Sept 11</strong> - Sri Lanka were supposed to host the 2020 edition, but the pandemic pushed event to 2021 before finally being moved to 2022</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jay Shah's term as Asian Cricket Council president extended by one year</strong> - Shah had taken over the reins of the ACC in January last year from Bangladesh Cricket Board president Nazmul Hassan</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Australia vs Pakistan | Steve Smith hopes to score big in Lahore Test</strong> - Steve Smith is disappointed not to have capitalised on two good starts against Pakistan</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IPL 2022 | I'm a work in progress, focussing on controllables: Hardik Pandya</strong> - Captain of new franchise Gujarat Titans, Pandya has been battling fitness concerns ever since injuring his back in 2019</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Geography in Indian Ocean is our basic advantage and we are utilising it: Navy</strong> - Building capacity to counter whatever capacity China can bring into the region, it tells House Committee</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Congress bags mayoral posts in Ballari Municipal Corporation</strong> - M. Rajeshwari and Malan B. got 29 of 44 votes each to get elected as Mayor and Deputy Mayor while their BJP rivals each polled 15 votes</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Manipur CM Biren summoned to Delhi again</strong> - The BJP is yet to form the government in the State</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>When forest fringes went up in flames</strong> - Forest department fights fires with the help of local peoples participation</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Gujarat govt.s 5th phase of water conservation campaign to generate 25 lakh mandays of work under MGNREGA</strong> - Chief Minister Bhupendra Patel formally launched the project with the deepening of a lake in the village, with the State aiming to carry out around 13,000 water conservation works by May 31.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russians board International Space Station in Ukrainian colours</strong> - Three cosmonauts ditch the standard-issue Russian uniforms in an apparent show of solidarity.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>French elections: Putins war gives Macron boost in presidential race</strong> - Russias invasion of Ukraine has shaken up Frances presidential elections, with only three weeks to go.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Putin hails Crimea annexation and war with lessons on heroism</strong> - Eight years after Russia seized Crimea, the event is being celebrated with a concert and in schools.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Four dead after US military plane crashes in Norway</strong> - All four passengers are killed in the accident, which involved a US Marine Corps aircraft.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lupin: Seven charged over armed heist on Paris filming set</strong> - Around 20 hooded attackers used fireworks to steal €300,000 worth of equipment from the crew.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How did a vast Amazon warehouse change life in a former mining town?</strong> - Looking back a decade after the mine closed and Amazon opened up. - <a href="https://arstechnica.com/?p=1842277">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leaked ransomware documents show Conti helping Putin from the shadows</strong> - Hacker gang sometimes acts in Russias interest, with ad hoc links to FSB, Cozy Bear. - <a href="https://arstechnica.com/?p=1842163">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Please stop putting COVID-19 test solution in your eyes and nose, FDA says</strong> - FDA says it has received reports that people are injuring themselves with the tests. - <a href="https://arstechnica.com/?p=1842304">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Android 13 preview locks down notifications, adds more to the tablet taskbar</strong> - Tablets get an apps button in the taskbar and what sounds like a smart-display mode. - <a href="https://arstechnica.com/?p=1842070">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Some types of brain studies need thousands of participants to be reliable</strong> - Researchers split up a big, reliable data set to find out where things go wrong. - <a href="https://arstechnica.com/?p=1842238">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>A man sitting next to me on the bus today showed me a picture of his wife.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He says to me “Isnt she beautiful”?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I replied to him “If you think shes pretty, you should see my wife”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He then asked “Oh, is your wife beautiful too”?, to which I replied “No, shes an optometrist”.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/graboidian"> /u/graboidian </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/thk2hk/a_man_sitting_next_to_me_on_the_bus_today_showed/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/thk2hk/a_man_sitting_next_to_me_on_the_bus_today_showed/">[comments]</a></span></p></li>
<li><strong>filthy old man</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A desperate looking woman stood poised on the edge of a cliff, about to jump off.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
An old homeless man who was wandering by stopped and said
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“Look since youll be dead in a few minutes, and it wont matter to you, how about a quickie before you go?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She screamed “NO! Fuck off you filthy old bastard”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He shrugged and turned away saying “OK then, Ill just wait at the bottom”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
(She didnt jump… Counselling works!!!)
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/mattysms1980"> /u/mattysms1980 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/thqla9/filthy_old_man/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/thqla9/filthy_old_man/">[comments]</a></span></p></li>
<li><strong>A woman marries a man and has 10 children. The man dies, so the woman remarries and has 10 more children. The next man dies, so the woman remarries again and has ten more children. That man dies, so the woman remarries and has 10 more children…</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The husband dies again and finally the woman dies as well.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
At the funeral, the priest mutters, “Thank God! Theyre finally together!”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A man at the funeral asks another man on his left, “Which husband do you think he means? The first, second, or third?”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man on his left says, “I think he means her legs.”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/808gecko808"> /u/808gecko808 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ths2fy/a_woman_marries_a_man_and_has_10_children_the_man/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ths2fy/a_woman_marries_a_man_and_has_10_children_the_man/">[comments]</a></span></p></li>
<li><strong>Once upon a time in a village, a man appeared and announced to the villagers that he would buy monkeys for $10 each…</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The villagers, seeing that there were many monkeys around, went out to the forest and started catching them.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man bought thousands at $10 and as supply started to diminish, the villagers stopped their effort. He further announced that he would now buy at $20. This renewed the efforts of the villagers and they started catching monkeys again.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Soon the supply diminished even further and people started going back to their farms. The offer increased to $25 each and the supply of monkeys became so little that it was an effort to even see a monkey, let alone catch it!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The man now announced that he would buy monkeys at $50! However, since he had to go to the city on some business, his assistant would now buy on behalf of him.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
In the absence of the man, the assistant told the villagers; “Look at all these monkeys in the big cage that the man has collected. I will sell them to you at $35 and when the man returns from the city, you can sell them to him for $50 each.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The villagers rounded up with all their savings and bought all the monkeys.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
They never saw the man nor his assistant, only monkeys everywhere!
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Now you have a better understanding of how the cryptocurrency market works.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/thaeg8/once_upon_a_time_in_a_village_a_man_appeared_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/thaeg8/once_upon_a_time_in_a_village_a_man_appeared_and/">[comments]</a></span></p></li>
<li><strong>Youre offered $50,000, but if you accept it the person you hate the most in the entire world will get $100,000. You taking it?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Yes why wouldnt I want $150,000.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/mostly-chill"> /u/mostly-chill </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/thh6b6/youre_offered_50000_but_if_you_accept_it_the/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/thh6b6/youre_offered_50000_but_if_you_accept_it_the/">[comments]</a></span></p></li>
</ul>
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