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 <h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-preprints">From Preprints</a></li>
 <li><a href="#from-clinical-trials">From Clinical Trials</a></li>
 <li><a href="#from-pubmed">From PubMed</a></li>
 <li><a href="#from-patent-search">From Patent Search</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
 <ul>
 <li><strong>The Effects of Coronavirus Victimization Distress and Coronavirus Racial Bias on Mental Health Among AIAN, Asian, Black, and Latinx Young Adults</strong> -
 <div>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Objectives. Racial/ethnic minorities have been disproportionately impacted by the COVID 19 pandemic in rates of infection and morbidity. The effect of Coronavirus specific forms of discrimination have not been examined. This study assessed the effect of economic, pre-existing health factors, and COVID 19 specific victimization and racial bias beliefs on depression and anxiety among young adults of color in the U.S. Methods. A national online survey of 399 AIAN, Asian, Black, and Latinx adults (18 to 25 years) included demographic variables, and measures of depression, anxiety, Coronavirus victimization distress (CVDS) and related racial bias beliefs (CRBS). Results. Employment, financial and prescription insecurity, COVID 19 health risks, CVDS and CRBS were positively correlated with depression and anxiety. CRBS was higher among Asian and Black respondents. SEM controlling for race/ethnicity and demographics indicated CRBS mediated the effect of CVDS on both mental health indices. Conclusion. COVID 19 has created new pathways to mental health disparities among young adults of color by reversing formerly protective factors such as employment, and by exacerbating structural and societal inequities linked to race. Findings highlight the necessity of creating mental health services tailored to the specific needs of racial/ethnic minorities during the current and future health crises. Public Significance Statement. COVID 19 has created new pathways to mental health disparities among young adults of color by reversing formerly protective factors such as employment, and by increasing Coronavirus stigma and racial bias. Mental health services need to be tailored to reducing such disparities during the current and future health crises.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.08.19.20178343v4" target="_blank">The Effects of Coronavirus Victimization Distress and Coronavirus Racial Bias on Mental Health Among AIAN, Asian, Black, and Latinx Young Adults</a>
 </div></li>
 <li><strong>Prediction of residue-specific contributions to binding and thermal stability using yeast surface display</strong> -
 <div>
 Quantitative prediction of residue-specific contributions to protein stability and activity is challenging, especially in the absence of experimental structural information. This is important for prediction and understanding of disease causing mutations, and for protein stabilization and design. Using yeast surface display of a saturation mutagenesis library of the bacterial toxin CcdB, we probe the relationship between ligand binding and expression level of displayed protein, with in vivo solubility in E.coli and in vitro thermal stability. We find that both the stability and solubility correlate well with the total amount of active protein on the yeast cell surface but not with total amount of expressed protein. We coupled FACS and deep sequencing to reconstruct the binding and expression mean fluorescent intensity of each mutant. The reconstructed mean fluorescence intensity (MFIseq) was used to differentiate between buried site, exposed non active-site and exposed active-site positions with high accuracy. The MFIseq was also used as a criterion to identify destabilized as well as stabilized mutants in the library, and to predict the melting temperatures of destabilized mutants. These predictions were experimentally validated and were more accurate than those of various computational predictors. The approach was extended to successfully identify buried and active-site residues in the receptor binding domain of the spike protein of SARS-CoV-2, suggesting it has general applicability.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.31.446445v1" target="_blank">Prediction of residue-specific contributions to binding and thermal stability using yeast surface display</a>
 </div></li>
 <li><strong>The Covid-19 Crisis and People’s Right to Food</strong> -
 <div>
 India’s national lockdown in 2020, in response to the Covid-19 crisis, was one of the harshest in the world. Multiple household surveys indicate that the lockdown and the economic recession that followed led to a severe nutrition crisis. Food deprivation was most intense during the national lockdown but continued throughout the year. Relief measures helped, but they compensated for just a fraction of people’s income losses, even among poor households. It is doubtful that employment, income and nutrition among informal-sector workers and their families ever regained their pre-lockdown levels before a second wave of the Covid-19 epidemic hit the country in early 2021. The Indian government’s failure to put in place more effective relief measures is a serious denial of people’s right to food. With relief measures off the table in 2021, at the time of writing, there is a serious danger of another wave of intense food deprivation.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/ybrmg/" target="_blank">The Covid-19 Crisis and People’s Right to Food</a>
 </div></li>
 <li><strong>COVID-19 Sex-Age Mortality Modeling - A Use Case of Risk-Based Vaccine Prioritization</strong> -
 <div>
 This research builds upon the previous publications claiming that the male sex population and both sex individuals of advanced age are more susceptible to COVID-19’s risks. Relations between sex and age gradients are explored analytically based upon the proposed log-polynomial regression model of COVID-19 mortality. This model enables predicting mortality risk at any arbitrary age, as well as the derivation of several useful secondary metrics: • Sex differential: a ratio of male-to-female death risks for a given age group. • Age parity: age at which both sexes have an equal vulnerability. • Age lag: the number of years to subtract from a male’s age to match a female’s death risk. • Male equal risk age: male’s age at which male’s odds of dying from COVID-19 will equate female’s given the cutoff age. These metrics allow solving such practical problems as, e.g., prioritizing vaccine based on COVID-19 mortality risk associated with sex and age. Modeling techniques, refined in the paper, are by no means unique to COVID-19 and would apply to analyses of other diseases.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/5c8bd/" target="_blank">COVID-19 Sex-Age Mortality Modeling - A Use Case of Risk-Based Vaccine Prioritization</a>
 </div></li>
 <li><strong>COVID-19 European regional tracker</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 This Tracker presents data on daily COVID-19 cases at the sub-national level for 26 European countries from January 2020 till present. Country-level data sources are identified and processed to form a homogenized panel at the NUTS3 or NUTS2 level, the two lowest standardized administrative units of Europe. The strengths and weaknesses of each country dataset are discussed in detail. The raw data, spatial layers, the code, and the final homogenized files are provided in an online repository for replication. The data highlights the spatial distribution of cases both within and across countries that can be utilized for a disaggregated analysis on the impacts of the pandemic. The Tracker is updated monthly to expand its coverage.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.02.15.21251788v3" target="_blank">COVID-19 European regional tracker</a>
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 <li><strong>Implementing Essential Coaching for Every Mother during COVID-19: A Pilot Pre-Post Intervention Study</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 OBJECTIVES: The primary objective was to evaluate the preliminary impact of Essential Coaching for Every Mother on self-efficacy, social support, postpartum anxiety and postpartum depression. The second objective was to explore the acceptability of the Essential Coaching for Every Mother program provided during the COVID-19 pandemic. METHODS: A prospective pre-post study was conducted with first time mothers in Nova Scotia, Canada between July 15th and September 19th, 2020. Participants completed a self-report survey at enrolment (after birth) and six-weeks postpartum. Various standardized measures were used and qualitative feedback on the program was also collected. Paired t-tests were carried out to determine changes from baseline to follow-up on psychosocial outcomes and qualitative feedback was analysed through thematic analysis. RESULTS: A total of 88 women enrolled. Self-efficacy increased between baseline (B) and follow-up (F) (B:33.33; F:37.11, p=0.000) while anxiety (STAI) declined (B:38.49; F:34.79; p=0.004). In terms of acceptability, 89% of participants felt that the number of messages were just right, 84.5% felt the messages contained all the information they needed relative to caring for a newborn and 98.8% indicated they would recommend this program to other new mothers. CONCLUSION: Essential Coaching for Every Mother may play a role in increasing maternal self-efficacy and decreasing anxiety, although future work with a control group is needed to delineate the true effects of the program. Overall, mothers were satisfied with the Essential Coaching for Every Mother program and would recommend it for other mothers, during COVID-19 and beyond.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.01.13.21249598v2" target="_blank">Implementing Essential Coaching for Every Mother during COVID-19: A Pilot Pre-Post Intervention Study</a>
 </div></li>
 <li><strong>Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants</strong> -
 <div>
 Both Pfizer-BNT162b2 and Moderna-mRNA-1273 vaccines can elicit an effective immune response against SARS-CoV-2 infection. However, the elicited serum antibody levels vary substantially and longitudinally decrease after vaccination. We examined the correlation of vaccination-induced IgG levels and neutralization titers against newly emerged variants remains and demonstrate a significant reduction of neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351) in Pfizer or Moderna vaccined sera. There was a significant and positive correlation between serum IgG levels and ID50 titers for not only SARS-CoV-2 WT but also the variants. These findings indicate that a high level of anti-spike IgG may offer better protection against infection from SARS-CoV-2 and its variants. Therefore, it is necessary to longitudinally monitor specific serum IgG level for evaluating the protective efficacy of the vaccines against SARS-CoV-2 and its new variants.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.31.445871v1" target="_blank">Correlation of vaccine-elicited antibody levels and neutralizing activities against SARS-CoV-2 and its variants</a>
 </div></li>
 <li><strong>Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2</strong> -
 <div>
 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 pandemic, most likely emerged from bats. A prerequisite for this devastating zoonosis was the ability of the SARS-CoV-2 Spike (S) glycoprotein to use human angiotensin-converting enzyme 2 (ACE2) for viral entry. Although the S protein of the closest related bat virus, RaTG13, shows high similarity to the SARS-CoV-2 S protein it does not efficiently interact with the human ACE2 receptor. Here, we show that a single T403R mutation allows the RaTG13 S to utilize the human ACE2 receptor for infection of human cells and intestinal organoids. Conversely, mutation of R403T in the SARS-CoV-2 S significantly reduced ACE2-mediated virus infection. The S protein of SARS-CoV-1 that also uses human ACE2 also contains a positive residue (K) at this position, while the S proteins of CoVs utilizing other receptors vary at this location. Our results indicate that the presence of a positively charged amino acid at position 403 in the S protein is critical for efficient utilization of human ACE2. This finding could help to predict the zoonotic potential of animal coronaviruses.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.31.446386v1" target="_blank">Spike mutation T403R allows bat coronavirus RaTG13 to use human ACE2</a>
 </div></li>
 <li><strong>Accelerated Antibody Discovery Targeting the SARS-CoV-2 Spike Protein for COVID-19 Therapeutic Potential</strong> -
 <div>
 Rapid deployment of technologies capable of high-throughput and high-resolution screening is imperative for timely response to viral outbreaks. Risk mitigation in the form of leveraging multiple advanced technologies further increases the likelihood of identifying efficacious treatments in an aggressive timeline. In this study, we describe two parallel, yet distinct, in vivo approaches for accelerated discovery of antibodies targeting the SARS-CoV-2 spike protein. Working with human transgenic Alloy-GK mice, we detail a single B-cell discovery workflow to directly interrogate antibodies secreted from plasma cells for binding specificity and ACE2 receptor blocking activity. Additionally, we describe a concurrent accelerated hybridoma-based workflow utilizing a DiversimAb mouse model for increased diversity. The panel of antibodies isolated from both workflows revealed binding to distinct epitopes with both blocking and non-blocking profiles. Sequence analysis of the resulting lead candidates uncovered additional diversity with the opportunity for straightforward engineering and affinity maturation. By combining in vivo models with advanced integration of screening and selection platforms, lead antibody candidates can be sequenced and fully characterized within one to three months.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.31.446421v1" target="_blank">Accelerated Antibody Discovery Targeting the SARS-CoV-2 Spike Protein for COVID-19 Therapeutic Potential</a>
 </div></li>
 <li><strong>COVID-19 Mortality is Associated with Impaired Innate Immunity in Pre-existing Health Conditions</strong> -
 <div>
 Background: COVID-19 poses a life-threatening endangerment to individuals with chronic diseases. However, not all comorbidities affect COVID-19 prognosis equally. Some increase the risk of COVID-19 related death by more than six folds while others show little to no impact. To prevent severe outcomes, it is critical that we comprehend pre-existing molecular abnormalities in common health conditions that predispose patients to poor prognoses. In this study, we aim to discover some of these molecular risk factors by associating gene expression dysregulations in common health conditions with COVID-19 mortality rates in different cohorts. Methods: We focused on fourteen pre-existing health conditions, for which age-and-sex-adjusted hazard ratios of COVID-19 mortality have been documented. For each health condition, we analyzed existing transcriptomics data to identify differentially expressed genes (DEGs) between affected individuals and unaffected individuals. We then tested if fold changes of any DEG in these pre-existing conditions were correlated with hazard ratios of COVID-19 mortality to discover molecular risk factors. We performed gene set enrichment analysis to identify functional groups overrepresented in these risk factor genes and examined their relationships with the COVID-19 disease pathway. Results: We found that upregulated expression of 70 genes and downregulated expression of 181 genes in pre-existing health conditions were correlated with increased risk of COVID-19 related death. These genes were significantly enriched with endoplasmic reticulum (ER) function, proinflammatory reaction, and interferon production that participate in viral transcription and immune responses to viral infections. Conclusions: Impaired innate immunity in pre-existing health conditions are associated with increased hazard of COVID-19 mortality. The discovered molecular risk factors are potential prognostic biomarkers and targets for therapeutic interventions.
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.31.446476v1" target="_blank">COVID-19 Mortality is Associated with Impaired Innate Immunity in Pre-existing Health Conditions</a>
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 <li><strong>Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19, A double-blind, randomized placebo-controlled trial.</strong> -
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 Background: Ivermectin, an antiparasitic agent, also has antiviral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early stage of COVID19 infection. Methods: The double blinded trial compared patients receiving ivermectin 0.2 mg/kg for 3 days vs. placebo in non-hospitalized COVID19 patients. RT-PCR from a nasopharyngeal swab was obtained at recruitment and then every two days. Primary endpoint was reduction of viral-load on the 6th day (third day after termination of treatment) as reflected by Ct level&gt;30 (non-infectious level). The primary outcome was supported by determination of viral culture viability. Results: Eighty nine patients were eligible (47 in ivermectin and 42 in placebo arm). Their median age was 35 years. Females accounted for 21.6%, and 16.8% were asymptomatic at recruitment. Median time from symptom onset was 4 days. There were no statistical differences in these parameters between the two groups. On day 6, 34 out of 47 (72%) patients in the ivermectin arm reached the endpoint, compared to 21/ 42 (50%) in the placebo arm (OR 2.62; 95% CI: 1.09 to 6.31). In a multivariable logistic regression model, the odds of a negative test at day 6 was 2.62 time higher in the ivermectin group (95% CI: 1.06 to 6.45). Cultures at days 2 to 6 were positive in 3/23 (13.0%) of ivermectin samples vs. 14/29 (48.2%) in the placebo group (p=0.008). Conclusions: There were significantly lower viral loads and viable cultures in the ivermectin group, which could lead to shortening isolation time in these patients.
 </p>
 </div>
 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.05.31.21258081v1" target="_blank">Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19, A double-blind, randomized placebo-controlled trial.</a>
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 <li><strong>Antigenic minimalism of SARS-CoV-2 is linked to surges in COVID-19 community transmission and vaccine breakthrough infections</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 The raging COVID-19 pandemic in India and reports of vaccine breakthrough infections globally have raised alarm mandating the characterization of the immuno-evasive features of SARS-CoV-2. Here, we systematically analyzed over 1.3 million SARS-CoV-2 genomes from 178 countries and performed whole-genome viral sequencing from 53 COVID-19 patients, including 20 vaccine breakthrough infections. We identified 116 Spike protein mutations that increased in prevalence during at least one surge in SARS-CoV-2 test positivity in any country over a three-month window. Deletions in the Spike protein N-terminal domain (NTD) are highly enriched for these surge-associated mutations (Odds Ratio = 18.2, 95% CI: 7.53-48.7; p=1.465x10-18). In the recent COVID-19 surge in India, an NTD deletion (ΔF157/R158) increased over 10-fold in prevalence from February 2021 (1.1%) to April 2021 (15%). During the recent surge in Chile, an NTD deletion (Δ246-253) increased rapidly over 30-fold in prevalence from January 2021 (0.86%) to April 2021 (33%). Strikingly, these simultaneously emerging deletions associated with surges in different parts of the world both occur at an antigenic supersite that is targeted by neutralizing antibodies. Finally, we generated clinically annotated SARS-CoV-2 whole genome sequences and identified deletions within this NTD antigenic supersite in a patient with vaccine breakthrough infection (Δ156-164) and other deletions from unvaccinated severe COVID-19 patients that could represent emerging deletion-prone regions. Overall, the expanding repertoire of NTD deletions throughout the pandemic and their association with case surges and vaccine breakthrough infections point to antigenic minimalism as an emerging evolutionary strategy for SARS-CoV-2 to evade immune responses. This study highlights the urgent need to sequence viral genomes at a larger scale globally and to mandate that sequences are deposited with more granular and transparent clinical annotations to ensure that therapeutic development keeps pace with the evolution of SARS-CoV-2.
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 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.05.23.21257668v1" target="_blank">Antigenic minimalism of SARS-CoV-2 is linked to surges in COVID-19 community transmission and vaccine breakthrough infections</a>
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 <li><strong>A molecular toolbox for ADP-ribosyl binding proteins</strong> -
 <div>
 Proteins interacting with ADP-ribosyl groups are often involved in disease-related pathways or in viral infections, which makes them attractive targets for the development of inhibitors. Our goal was to develop a robust and accessible assay technology that is suitable for high-throughput screening and applicable to a wide range of proteins acting as either hydrolysing or non-hydrolysing binders of mono- and poly-ADP-ribosyl groups. As a foundation of our work, we developed a C-terminal protein fusion tag based on a Gi protein alpha subunit peptide (GAP), which allows for site-specific introduction of cysteine-linked mono- and poly-ADP-ribosyl groups as well as chemical ADP-ribosyl analogs. By fusion of the GAP-tag and ADP-ribosyl binders to fluorescent proteins, we were able to generate robust FRET signals and the interaction with 22 previously described ADP-ribosyl-binders was confirmed. To demonstrate the applicability of this binding assay for high-throughput screening, we utilized it to screen for inhibitors of the SARS-CoV-2 nsp3 macrodomain and identified the drug suramin as a moderate yet unspecific inhibitor of this protein. To complement the binding technology, we prepared high-affinity ADP-ribosyl binders fused to a nanoluciferase, which enabled simple blot-based detection of mono- and poly-ADP-ribosylated proteins. These tools can be expressed recombinantly in E. coli using commonly available agents and will help to investigate ADP-ribosylation systems and aid in drug discovery.
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 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.31.445082v1" target="_blank">A molecular toolbox for ADP-ribosyl binding proteins</a>
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 <li><strong>Characterising long term Covid-19: a living systematic review</strong> -
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Background While it is now apparent clinical sequelae (often called Long Covid) may persist after acute Covid-19, their nature, frequency, and aetiology are poorly characterised. This study aims to regularly synthesise evidence on Long Covid characteristics, to inform clinical management, rehabilitation, and interventional studies to improve long term outcomes. Methods A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research Database on Covid-19, LitCOVID, and Google Scholar were searched up to 17th March 2021. Published studies including at least 100 people with confirmed or clinically suspected Covid-19 at 12 weeks or more post-onset were included. Results were analysed using descriptive statistics and meta-analyses to estimate prevalence with 95% confidence intervals (CIs). Results Thirty-nine studies were included: 32 cohort, six cross-sectional, and one case-control. Most showed high or moderate risk of bias. None were set in low-income countries, limited studies included children. Studies reported on 10,951 people (48% female) in 12 countries. Most followed-up post hospital discharge (78%, 8520/10951). The longest mean follow-up was 221.7 (SD: 10.9) days post Covid-19 onset. An extensive range of symptoms with wide prevalence was reported, most commonly weakness (41%; 95% CI 25% to 59%), malaise (33%; 95% CI 15% to 57%), fatigue (31%; 95% CI 24% to 39%), concentration impairment (26%; 95% CI 21% to 32%), and breathlessness (25%; 95% CI 18% to 34%). Other frequent symptoms included musculoskeletal, neurological, and psychological. 37% (95% CI 18% to 60%) of people reported reduced quality of life. Conclusion: Long Covid is a complex condition with heterogeneous symptoms. The nature of the studies precludes a precise case definition or evaluation of risk factors. There is an urgent need for prospective, robust, standardised controlled studies into aetiology, risk factors, and biomarkers to characterise Long Covid in different at-risk populations and settings. Systematic review registration The protocol was prospectively registered on the PROSPERO database (CRD42020211131).
 </p>
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 <div class="article-link article-html-link">
 🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.08.20246025v2" target="_blank">Characterising long term Covid-19: a living systematic review</a>
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 <li><strong>Kite-shaped molecules block SARS-CoV-2 cell entry at a post-attachment step</strong> -
 <div>
 Anti-viral small molecules are currently lacking for treating coronavirus infection. The long development timescales for such drugs are a major problem, but could be shortened by repurposing existing drugs. We therefore screened a small library of FDA-approved compounds for potential severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antivirals using a pseudovirus system that allows a sensitive read-out of infectivity. A group of structurally-related compounds, showing moderate inhibitory activity with IC50 values in the 1-5M range, were identified. Further studies demonstrated that these kite-shaped molecules were surprisingly specific for SARS-CoV and SARS-CoV-2 and that they acted early in the entry steps of the viral infectious cycle, but did not affect virus attachment to the cells. Moreover the compounds were able to prevent infection in both kidney- and lung-derived human cell lines. The structural homology of the hits allowed the production of a well-defined pharmacophore that was found to be highly accurate in predicting the anti-viral activity of the compounds in the screen. We discuss the prospects of repurposing these existing drugs for treating current and future coronavirus outbreaks.
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 🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2021.05.29.446272v1" target="_blank">Kite-shaped molecules block SARS-CoV-2 cell entry at a post-attachment step</a>
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 <h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Allogeneic Adipose-Derived Mesenchymal Stem Cells for Treatment of COVID-19 Acute Respiratory Distress</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: COVI-MSC;   Drug: Placebo<br/><b>Sponsor</b>:   Sorrento Therapeutics, Inc.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate a Single Intranasal Dose of STI-2099 (COVI-DROPS™) in Outpatient Adults With COVID-19 (US)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: COVI-DROPS;   Drug: Placebo<br/><b>Sponsor</b>:   Sorrento Therapeutics, Inc.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Evaluate a Single Intranasal Dose of STI-2099 (COVI-DROPS™) in Outpatient Adults With COVID-19 (UK)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Biological: COVI-DROPS;   Drug: Placebo<br/><b>Sponsor</b>:   Sorrento Therapeutics, Inc.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Low-Dose Radiation Therapy to Lungs in Moderate COVID-19 Pneumonitis: A Case-Control Pilot Study</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Radiation: Low dose radiotherapy<br/><b>Sponsor</b>:   Mahatma Gandhi Institute of Medical Sciences<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CRP-Apheresis for Attenuation of Pulmonary, MYocardial and/or Kidney Injury in COvid-19</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Device: CRP-apheresis<br/><b>Sponsor</b>:   University Hospital, Essen<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Using Text Messages to Improve COVID-19 Vaccination Uptake</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Behavioral: Text message content<br/><b>Sponsors</b>:   Imperial College Healthcare NHS Trust;   Central London CCG;   Imperial College Health Partners;   Institute for Global Health Innovations;   The Behavioural Insights Team<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prophylaxis for COVID-19: Ivermectin in Close Contacts of COVID-19 Cases (IVERNEX-TUC)</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Ivermectin;   Other: Placebo<br/><b>Sponsor</b>:   Ministry of Public Health, Argentina<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mix and Match of the Second COVID-19 Vaccine Dose for Safety and Immunogenicity</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: mRNA-1273 SARS-CoV-2 vaccine;   Biological: BNT162b2;   Biological: ChAdOx1-S [recombinant];   Other: 0, 28 day schedule;   Other: 0, 112 day schedule<br/><b>Sponsors</b>:   Canadian Immunization Research Network;   Canadian Center for Vaccinology;   BC Children’s Hospital Research Institute;   Children’s Hospital Research Institute of Manitoba;   CHU de Quebec-Universite Laval;   Ottawa Hospital Research Institute;   Northern Alberta Clinical Trials + Research Centre;   Ontario Agency for Health Protection and Promotion;   University of Toronto;   Massachusetts General Hospital<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CISCO-21 Prevent and Treat Long COVID-19.</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Other: Resistance Exercise<br/><b>Sponsors</b>:   NHS Greater Glasgow and Clyde;   University of Glasgow;   Chief Scientist Office of the Scottish Government<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leronlimab in Moderatelly Ill Patients With COVID-19 Pneumonia</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: Leronlimab;   Drug: Placebo<br/><b>Sponsors</b>:   Hospital Israelita Albert Einstein;   CytoDyn, Inc.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Anti COVID 19 Intravenous Immunoglobulin (C-IVIG) Therapy for Severe COVID-19 Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Biological: Anti COVID 19 Intravenous Immunoglobulin (C-IVIG)<br/><b>Sponsors</b>:   Dow University of Health Sciences;   Higher Education Commission (Pakistan)<br/><b>Recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leronlimab in Critically Ill Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Drug: Leronlimab;   Drug: Placebo<br/><b>Sponsors</b>:   Hospital Israelita Albert Einstein;   CytoDyn, Inc.<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Amantadine for COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Amantadine;   Drug: Lactose monohydrate<br/><b>Sponsors</b>:   Copenhagen University Hospital, Hvidovre;   University of Copenhagen<br/><b>Not yet recruiting</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Intervention</b>:   Biological: Mesenchymal Stem Cells Transplantation<br/><b>Sponsors</b>:   SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi;   Istinye University;   Liv Hospital (Ulus)<br/><b>Completed</b></p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antigen Rapid Test Screening to Prevent SARS-CoV-2 Transmission (COVID-19) at Mass Gathering Events.</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Diagnostic Test: SARS-CoV-2 antigen rapid test<br/><b>Sponsors</b>:   Norwegian Institute of Public Health;   University of Oslo<br/><b>Not yet recruiting</b></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Quercetin for COVID-19 and DENGUE co-infection: a potential therapeutic strategy of targeting critical host signal pathways triggered by SARS-CoV-2 and DENV</strong> - CONCLUSIONS: This study is the first to reveal quercetin as a pharmacological drug for COVID-19 and DENGUE co-infection. COVID-19 and DENGUE co-infection remain a potential threat to the world’s public health system. Therefore, we need innovative thinking to provide admissible evidence for quercetin as a potential molecule drug for the treatment of COVID-19 and DENGUE, but the findings have not been verified in actual patients, so further clinical drug trials are needed.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TLR7 Ligation Inhibits TLR8 Responsiveness in IL-27-Primed Human THP-1 Monocytes and Macrophages</strong> - Regulation of proinflammatory cytokine expression is critical in the face of single-stranded RNA (ssRNA) virus infections. Many viruses, including coronavirus and influenza virus, wreak havoc on the control of cytokine expression, leading to the formation of detrimental cytokine storms. Understanding the regulation and interplay between inflammatory cytokines is critical to the identification of targets involved in controlling the induction of cytokine expression. In this study, we focused on…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG</strong> - Hydroxychloroquine (HCQ) was noted to produce severe cardiac arrhythmia, an adverse effect as its use against severe acute respiratory syndrome caused by coronavirus 2 (SAES-CoV-2). HCQ is an antimalarial drug with quinoline structure. Some other quinoline compounds, such as fluoroquinolone antibiotics (FQs), also lead to arrhythmias characterized by QT prolongation. QT prolongation is usually related to the human ether-a-go-go-related gene (hERG) potassium channel inhibitory activity of most…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Structure-based design and characterization of novel fusion-inhibitory lipopeptides against SARS-CoV-2 and emerging variants</strong> - The ongoing pandemic of COVID-19, caused by SARS-CoV-2, has severely impacted the global public health and socio-economic stability, calling for effective vaccines and therapeutics. In this study, we continued our efforts to develop more efficient SARS-CoV-2 fusion inhibitors and achieved significant findings. First, we found that the membrane-proximal external region (MPER) sequence of SARS-CoV-2 spike fusion protein plays a critical role in viral infectivity and can serve as an ideal template…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 death</strong> - Most COVID-19 victims are old and die from unrelated causes. Here we present twelve complete autopsies, including two rapid autopsies of young patients where the cause of death was COVID-19 ARDS. The main virus induced pathology was in the lung parenchyma and not in the airways. Most coagulation events occurred in the intra-alveolar and not in the intra-vascular space and the few thrombi were mainly composed of aggregated thrombocytes. The dominant inflammatory response was the massive…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Accommodating receptor flexibility and free energy calculation to reduce false positive binders in the discovery of natural products blockers of SARS-COV-2 spike RBD-ACE2 interface</strong> - The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2), which causes coronavirus disease-19 (COVID-19) has caused more than 2 million deaths around the globe. The high transmissibility rate of the disease is related to the strong interaction between the virus spike receptor-binding domain (RBD) and the human angiotensin-converting enzyme 2 (ACE2) as documented in several reports. In this study, using state-of-the-art computational methods, natural products were screened…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Synthetic Siglec-9 Agonists Inhibit Neutrophil Activation Associated with COVID-19</strong> - Severe cases of coronavirus disease 2019 (COVID-19), caused by infection with SARS-CoV-2, are characterized by a hyperinflammatory immune response that leads to numerous complications. Production of proinflammatory neutrophil extracellular traps (NETs) has been suggested to be a key factor in inducing a hyperinflammatory signaling cascade, allegedly causing both pulmonary tissue damage and peripheral inflammation. Accordingly, therapeutic blockage of neutrophil activation and NETosis, the cell…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The First Insight Into the Supramolecular System of <em>D,L</em>-α-Difluoromethylornithine: A New Antiviral Perspective</strong> - Targeting the polyamine biosynthetic pathway by inhibiting ornithine decarboxylase (ODC) is a powerful approach in the fight against diverse viruses, including SARS-CoV-2. Difluoromethylornithine (DFMO, eflornithine) is the best-known inhibitor of ODC and a broad-spectrum, unique therapeutical agent. Nevertheless, its pharmacokinetic profile is not perfect, especially when large doses are required in antiviral treatment. This article presents a holistic study focusing on the molecular and…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prediction of repurposed drugs for Coronaviruses using artificial intelligence and machine learning</strong> - The world is facing the COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Likewise, other viruses of the Coronaviridae family were responsible for causing epidemics earlier. To tackle these viruses, there is a lack of approved antiviral drugs. Therefore, we have developed robust computational methods to predict the repurposed drugs using machine learning techniques namely Support Vector Machine, Random Forest, k-Nearest Neighbour, Artificial Neural…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Intestinal Microbiota-A Promising Target for Antiviral Therapy?</strong> - The intestinal microbiota is thought to be an important biological barrier against enteric pathogens. Its depletion, however, also has curative effects against some viral infections, suggesting that different components of the intestinal microbiota can play both promoting and inhibitory roles depending on the type of viral infection. The two primary mechanisms by which the microbiota facilitates or inhibits viral invasion involve participation in the innate and adaptive immune responses and…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles</strong> - Human SP-D is a potent innate immune molecule whose presence at pulmonary mucosal surfaces allows its role in immune surveillance against pathogens. Higher levels of serum SP-D have been reported in the patients with severe acute respiratory syndrome coronavirus (SARS-CoV). Studies have suggested the ability of human SP-D to recognise spike glycoprotein of SARS-CoV; its interaction with HCoV-229E strain leads to viral inhibition in human bronchial epithelial (16HBE) cells. Previous studies have…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>beta-Caryophyllene, A Natural Dietary CB2 Receptor Selective Cannabinoid can be a Candidate to Target the Trinity of Infection, Immunity, and Inflammation in COVID-19</strong> - Coronavirus disease (COVID-19), caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an ongoing pandemic and presents a public health emergency. It has affected millions of people and continues to affect more, despite tremendous social preventive measures. Identifying candidate drugs for the prevention and treatment of COVID-19 is crucial. The pathogenesis and the complications with advanced infection mainly involve an immune-inflammatory cascade. Therefore,…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Flavonoids are promising safe therapy against COVID-19</strong> - Flavonoids are a class of phenolic natural products, well-identified in traditional and modern medicines in the treatment of several diseases including viral infection. Flavonoids showed potential inhibitory activity against coronaviruses including the current pandemic outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and designated as COVID-19. Here, we have collected all data related to the potential inhibitory mechanisms of flavonoids against SARS-CoV-2…</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Potential protective mechanisms of green tea polyphenol EGCG against COVID-19</strong> - BACKGROUND: The world is in the midst of the COVID-19 pandemic. In this comprehensive review, we discuss the potential protective effects of (-)-epigallocatechin-3-gallate (EGCG), a major constituent of green tea, against COVID-19.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DFT, Molecular Docking and Molecular Dynamics Simulation Studies on Some Newly Introduced Natural Products for Their Potential Use Against SARS-CoV-2</strong> - Throughout the history, natural products always give new paths to develop new drugs. As with many other diseases, natural compounds can be helpful in the treatment of COVID-19. SARS-CoV-2 main protease enzyme has an important role in viral replication and transcription. Therefore, inhibiting this enzyme may be helpful in the treatment of COVID-19. In this study, it is aimed to investigate eight natural compounds which have recently entered the literature, computationally for their potential use…</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COST EFFECTIVE PORTABLE OXYGEN CONCENTRATOR FOR COVID-19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU324964715">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>METHOD OF IDENTIFYING SEVERE ACUTE RESPIRATORY SYNDROME CORONA VIRUS 2 (SARS-COV-2) RIBONUCLEIC ACID (RNA)</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323956811">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IMPROVEMENTS RELATED TO PARTICLE, INCLUDING SARS-CoV-2, DETECTION AND METHODS THEREFOR</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295937">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>DEEP LEARNING BASED SYSTEM FOR DETECTION OF COVID-19 DISEASE OF PATIENT AT INFECTION RISK</strong> - The present invention relates to Deep learning based system for detection of covid-19 disease of patient at infection risk. The objective of the present invention is to solve the problems in the prior art related to technologies of detection of covid-19 disease using CT scan image processing. - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN324122821">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A COMPREHENSIVE DISINFECTION SYSTEM DURING PANDEMIC FOR PERSONAL ITEMS AND PROTECTIVE EQUIPMENT (PPE) TO SAFEGUARD PEOPLE</strong> - The current Covid-19 pandemic has led to an enormous demand for gadgets / objects for personal protection. To prevent the spread of virus, it is important to disinfect commonly touched objects. One of the ways suggested is to use a personal UV-C disinfecting box that is “efficient and effective in deactivating the COVID-19 virus. The present model has implemented the use of a UV transparent material (fused silica quartz glass tubes) as the medium of support for the objects to be disinfected to increase the effectiveness of disinfection without compromising the load bearing capacity. Aluminum foil, a UV reflecting material, was used as the inner lining of the box for effective utilization of the UVC light emitted by the UVC lamps. Care has been taken to prevent leakage of UVC radiation out of the system. COVID-19 virus can be inactivated in 5 minutes by UVC irradiation in this disinfection box - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=IN322882412">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UBIQUITOUS COMPUTING SYSTEM FOR MENTAL HEALTH MONITORING OF PERSON DURING THE PANDEMIC OF COVID-19</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU323295498">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种预判重症新冠肺炎（COVID-19）的标志物及其产品和用途</strong> - 本发明提供了一种预判重症疾病的标志物，所述的预判重症疾病的标志物为S100A12，序列为SEQ ID NO.1，所述的重症疾病为重症新冠肺炎、重症感染中的一种。S100A12基因作为标志物，在预判重症疾病时对全血中的S100A12基因的表达水平进行检测即可，无需对白细胞进行分离，简化检测流程。S100A12的表达水平可以指导感染类疾病包括新冠肺炎重症的预判，从而及早施治，降低病死率，具有很好的临床应用前景。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN325296031">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>INDICATING SYSTEM</strong> - A visual indicating system for use with a hospital bed, the hospital bed comprising a bed frame extending between a head end and a foot end of the bed frame, the visual indicating system comprising: an indicating member adapted to be coupled with the bed frame wherein the indicating member comprises an indicia for indicating one of a plurality of pre-determined health conditions.</p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">FIGURE 1 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU322897510">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>USE OF IMINOSUGAR COMPOUND IN PREPARATION OF ANTI-SARS-COV-2 VIRUS DRUG</strong> - - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=AU322897928">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种高灵敏SARS-CoV-2中和抗体的检测方法、检测试剂盒</strong> - 本发明公开了一种高灵敏SARS‑CoV‑2中和抗体的检测方法、检测试剂盒，属于生物医学检测技术领域，本发明试剂盒包括层析试纸、卡壳和样本稀释液，所述层析试纸包括底板、样品垫、结合垫、NC膜和吸水垫，所述NC膜上依次设置有捕获线、检测线和质控线，所述捕获线包被有ACE2蛋白，所述检测线包被有RBD蛋白，所述结合垫设置有RBD蛋白标记物；本发明采用阻断法加夹心法原理提高检测中和抗体的灵敏度，通过添加捕获线的方式，将靶向RBD的非中和抗体提前捕获，保证后续通过夹心法检测中和抗体的特异性。 - <a href="https://patentscope.wipo.int/search/en/detail.jsf?docId=CN323798634">link</a></p></li>
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 <h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
 <h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
 <ul>
 <li><a href="#from-new-yorker">From New Yorker</a></li>
 <li><a href="#from-vox">From Vox</a></li>
 <li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
 <li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
 <li><a href="#from-bbc-europe">From BBC: Europe</a></li>
 <li><a href="#from-ars-technica">From Ars Technica</a></li>
 <li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
 </ul>
 <h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Sudden Rise of the Coronavirus Lab-Leak Theory</strong> - Scientists and political commentators are no longer dismissing the possibility that COVID-19 emerged from a Chinese laboratory. What changed? - <a href="https://www.newyorker.com/news/annals-of-inquiry/the-sudden-rise-of-the-coronavirus-lab-leak-theory">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>American Democracy Isn’t Dead Yet, but It’s Getting There</strong> - A country that cannot even agree to investigate an assault on its Capitol is in big trouble, indeed. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/american-democracy-isnt-dead-yet-but-its-getting-there">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>California’s Novel Attempt at Land Reparations</strong> - Property seized from a Black family a century ago is being returned to their descendants. - <a href="https://www.newyorker.com/news/us-journal/californias-novel-attempt-at-land-reparations">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>La lucha por mejorar las tasas de vacunación entre los latinos en Nueva York</strong> - Enormes disparidades persisten en los niveles de inmunización entre las comunidades de la ciudad. - <a href="https://www.newyorker.com/news/our-local-correspondents/la-lucha-por-mejorar-las-tasas-de-vacunacion-entre-los-latinos-en-nueva-york">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Republican Party, Racial Hypocrisy, and the 1619 Project</strong> - As the G.O.P. seeks to deny Americans knowledge of their own history, Nikole Hannah-Jones is denied tenure. - <a href="https://www.newyorker.com/news/daily-comment/the-republican-party-racial-hypocrisy-and-the-1619-project">link</a></p></li>
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 <h1 data-aos="fade-right" id="from-vox">From Vox</h1>
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 <li><strong>June is stacked with new movies. Here are 12 to watch for.</strong> -
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 <img alt="Two images, one from In the Heights and one from Zola. Both are brightly colored pictures of scenes from the movie in which two people look at one another." src="https://cdn.vox-cdn.com/thumbor/9gyZpU8G8mN6mC-7DtuFElZS9J8=/100x0:1700x1200/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69370926/headshots_1622128525455.0.jpg"/>
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 <em>In the Heights</em> and <em>Zola</em> are both due out in June. | Warner Bros./A24
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 Beach vacations, tragic romances, a living legend, and more.
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 <a href="https://www.vox.com/22419048/summer-movies-2021-blockbusters-streaming">Movies are back in full force this summer</a>, and June feels like the month the floodgates break. There’s action comedies! Experimental documentaries! Sexy European romantic tragedies! Horror flicks! <a href="https://www.vox.com/22440448/in-the-heights-movie-review-miranda-ramos-chu-hudes"><em>In the Heights</em></a> is coming out and so is <em>Zola</em>. Plus a new Pixar movie and an animated film about a chainsaw-wielding George Washington leading a team to fight Benedict Arnold. Get ready, friends.
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 Here are a dozen of June’s most interesting films to look for in theaters or on streaming platforms.
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 <em>All Light Everywhere</em>
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 <strong>Release date: </strong>June 4
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 We undeniably live in a surveillance society. Cameras are ubiquitous, from body cameras on cops to drone-enabled cameras that capture views from above to the phone cameras we hold in our hands every day. But what do cameras miss? Do they really give us a more objective view of reality? Those are the questions Theo Anthony (<em>Rat Film</em>) tackles in <em>All Light, Everywhere</em>, a sprawling essay film about “blind spots” in the technologies we trust (or don’t trust) to keep us safe and the illusions they too often depend upon. Watching <em>All Light, Everywhere</em> is informative, but more importantly, it’s an experience — and a sobering one.
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 <strong>How to watch it:</strong> <em>All Light, Everywhere</em> will premiere in theaters.
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 <em>The Conjuring: The Devil Made Me Do It</em>
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 <strong>Release date: </strong>June 4
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 The latest installment in the <em>Conjuring</em> universe (and a direct sequel to <a href="https://www.vox.com/2016/6/10/11874598/the-conjuring-2-review-scarier-than-original">2016’s <em>The Conjuring 2</em></a>) returns to paranormal investigative couple Ed and Lorraine Warren (Patrick Wilson and Vera Farmiga). The Warrens were <a href="https://en.wikipedia.org/wiki/Ed_and_Lorraine_Warren">real people</a>, and just like other movies from the series, this one draws on their files for its source material. Some of the story in <em>The Conjuring: The Devil Made Me Do It</em> is expected — a little boy exhibits weird behavior, and the Warrens are convinced it’s a case of possession. But the film also covers <a href="https://en.wikipedia.org/wiki/Trial_of_Arne_Cheyenne_Johnson">the first court case in US history in which a murder suspect used demonic possession as a defense</a>. If the previous <em>Conjuring</em> films are any indication, <em>The Devil Made Me Do It</em> will be taut and spooky.
 </p>
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 <strong>How to watch it: </strong><em>The Conjuring: The Devil Made Me Do It</em> will premiere in theaters and stream on HBO Max.
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 <em>Undine</em>
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 <strong>Release date: </strong>June 4
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 Christian Petzold, one of Europe’s greatest living filmmakers (<em>Transit</em>; <em>Barbara</em>), returns with <em>Undine</em>, which transports an ancient mythological creature into the present day. In European mythology, an “undine” is a water nymph who falls in love with a man, but will die if he is unfaithful to her. In <em>Undine</em>, a (modern-day) historian who studies the urban development of Berlin falls in love with a man, but he betrays her — and she must kill him and return to the water. It’s stylish, passionate, and full of enchantment.
 </p>
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 <strong>How to watch it: </strong><em>Undine</em> will premiere in theaters.
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 <a href="https://www.vox.com/22440448/in-the-heights-movie-review-miranda-ramos-chu-hudes"><em>In the Heights</em></a>
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 <strong>Release date:</strong> June 11
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g1TWre">
 <em>In the Heights</em> is poised to be the smash hit of the summer — and that would probably be true even if it wasn’t perfectly timed to welcome moviegoers back to theaters after a long pandemic year. Lin-Manuel Miranda’s (pre-<em>Hamilton</em>) musical was a hit on Broadway, and now it’s been translated to the big screen by <a href="https://www.vox.com/summer-movies/2018/8/14/17688338/crazy-rich-asians-review-constance-wu-henry-golding-gemma-chan-romantic-comedy"><em>Crazy Rich Asians</em></a> director Jon M. Chu. Starring a bevy of talent — Anthony Ramos, Corey Hawkins, Leslie Grace, Melissa Barrera, Olga Merediz, Daphne Rubin-Vega, Gregory Diaz IV, Stephanie Beatriz, Dascha Polanco, Jimmy Smits, Marc Anthony, and Miranda himself — it’s a joyful, music-filled story about a community pulling together and their dreams of a better life.
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 <strong>How to watch it:</strong> <em>In the Heights </em>will open in theaters and on HBO Max.
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 <em>Hitman’s Wife’s Bodyguard</em>
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 <strong>Release date: </strong>June 16
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 As you may have deduced from the title, <em>Hitman’s Wife’s Bodyguard</em> is a sequel to the 2017 comedy <em>The Hitman’s Bodyguard</em>, in which Michael Bryce (Ryan Reynolds) must protect hitman Darius Kincaid (Samuel L. Jackson) from a bunch of pretty bad dudes. Everyone’s back for the new film, including Darius’s wife Sonia (Salma Hayek), who drags Bryce — who’s been on a sabbatical, at his company’s insistence — back into the fray. Will it be kind of stupid? Probably. But Jackson, Reynolds, and Hayek all have proven comedy chops, so it’s also likely to be the platonic ideal of a mindless summer blockbuster.
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 <strong>How to watch it: </strong><em>Hitman’s Wife’s Bodyguard</em> will open in theaters.
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 <em>Luca</em>
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 <strong>Release date:</strong> June 18
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 Pixar’s latest is set in the Italian Riviera, a place I’d give my eyeteeth to vacation in right about now. The film is<em> </em>a coming-of-age story about a kid named Luca, who’s about to have the best summer of his life in Italy. He meets another boy and they become fast friends. But Luca has a secret: He’s actually a sea monster. What? I don’t know, but it sounds fun to me.
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 <strong>How to watch it: </strong><em>Luca </em>will premiere on Disney+.
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 <em>Rita Moreno: Just a Girl Who Decided to Go For It</em>
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 <strong>Release date: </strong>June 18
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="K6BYKT">
 Living legend Rita Moreno is one of the most highly decorated actors in American entertainment, and her success spans decades: Her first major award was the Best Supporting Actress Oscar for <em>West Side Story</em> in 1961. (She’s also one of the few actors to ever accomplish the elusive EGOT — Emmy, Grammy, Oscar, Tony.) But more importantly, she’s an absolute icon, a woman who blazed trails for Latinas — Moreno is from Puerto Rico — with determination, commitment, and skill. In this documentary, she tells her story, from the good times to the hard times, and it is absolutely delightful.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BKlcip">
 <strong>How to watch it: </strong><em>Rita Moreno: Just a Girl Who Decided to Go For It</em> will premiere in theaters.
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 <em>Summer of 85</em>
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 <strong>Release date: </strong>June 18
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 French director François Ozon makes entertaining, passionate melodramas, and <em>Summer of 85</em> is no exception. The drama — which premiered at the virtual Toronto International Film Festival last fall — is about a 16-year-old named Alexis (Félix Lefebvre), who is spending his summer at a seaside resort in Normandy. He meets David (Benjamin Voisin), and they fall into a relationship that quickly becomes a romance. But tragedy is always lurking around the edges. <em>Summer of 85</em> is a coming-of-age story, and if you’re up for some sexy French summer fun and emotional implosions, this is it.
 </p>
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 <strong>How to watch it: </strong><em>Summer of 85</em> will premiere in theaters.
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 </p>
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 <em>F9</em>
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 <strong>Release date: </strong>June 25
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 You don’t go see a <em>Fast &amp; Furious</em> movie for the plot; you go for the cars and the camaraderie, and that’s what <em>F9</em> promises to serve up as well. Directed and co-written (with Daniel Casey) by Justin Lin, who also made <em>Fast &amp; Furious 6</em>, <em>F9</em> has been delayed several times due to the pandemic. But now it’s here, with a stacked cast: Vin Diesel, Michelle Rodriguez, Tyrese Gibson, Chris “Ludacris” Bridges, John Cena, Jordana Brewster, Nathalie Emmanuel, Sung Kang, Helen Mirren, and Charlize Theron.<em> </em>Presumably, there will also be really cool stunts.
 </p>
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 <strong>How to watch it: </strong><em>F9</em> will open in theaters.
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 <em>False Positive</em>
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 <strong>Release date: </strong>June 25
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 <em>Broad City</em>’s Ilana Glazer co-wrote <em>False Positive </em>with director John Lee, and it’s a spin on <em>Rosemary’s Baby</em>. Glazer plays Lucy, who has been trying to get pregnant with her partner Adrian (Justin Theroux), with little success. Then they find a fertility doctor they love, Dr. Hindle (Pierce Brosnan), and hopes run high. But when Lucy becomes pregnant, she starts to suspect something is afoot with Dr. Hindle and sets out to investigate. A spooky horror film about pregnancy? Sounds great to me.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w3cMpM">
 <strong>How to watch it: </strong><em>False Positive</em> will premiere on Hulu.
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 <em>Zola</em>
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 <strong>Release date: </strong>June 30
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 I am reasonably confident that <em>Zola </em>(which premiered at Sundance in 2020) is the first movie based on a Twitter thread, and it is a humdinger. In 2015, dancer A’Ziah King — who goes by Zola — <a href="https://www.rollingstone.com/feature/zola-tells-all-the-real-story-behind-the-greatest-stripper-saga-ever-tweeted-73048/">told the story, in 148 tweets, of a strange but true trip to Florida</a> with a girl named Stefani; the trip went terribly, terribly wrong when King discovered Stefani’s “roommate” was actually her pimp. King later admitted that some parts of her account were exaggerated, but <em>Zola </em>director<em> </em>Janicza Bravo is less interested in facts than she is in crafting an entertaining tale and exploring how our perceptions of the characters are affected by who’s telling the story. It’s wild, raunchy, and very funny, with a cast that includes Riley Keough, Colman Domingo, Nicholas Braun (a.k.a. <em>Succession</em>’s Cousin Greg), and a marvelous Taylour Paige, plus a screenplay co-written by Bravo and <a href="https://www.vox.com/culture/2019/12/5/20961826/slave-play-broadway-2019-review"><em>Slave Play</em></a> writer Jeremy O. Harris.
 </p>
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 <strong>How to watch it: </strong><em>Zola</em> will open in theaters.
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 <em>America: The Motion Picture</em>
 </h3>
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 <img alt="Animation of six characters, five in pants and stars-and-stripes shirts and one in armor, standing on a pile of rubble." src="https://cdn.vox-cdn.com/thumbor/sA5jTzwz2TYjEim37lZ8t9AFZUw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22541226/America__The_Motion_Picture_01_19_07_14.jpg"/> <cite>Netflix</cite>
 <figcaption>
 Killer Mike as “Blacksmith,” Olivia Munn as “Thomas Edison,” Jason Mantzoukas as “Samuel Adams,” Channing Tatum as “George Washington,” Bobby Moynihan as “Paul Revere,” and Raoul Max Trujillo as “Geronimo” in a still from <em>America: The Motion Picture</em>.
 </figcaption>
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 <strong>Release date: </strong>Wednesday, June 30
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Isg3rY">
 This movie sounds very wild, which is probably the idea. It’s kind of a revisionist history of America, helmed by <em>Archer </em>executive producer Matt Thompson; George Washington (voiced by Channing Tatum, who’s also one of the film’s producers) leads a team to take on Benedict Arnold and King James, and Washington, uh, wields a chainsaw? Phil Lord and Christopher Miller of <em>Lego Movie</em> fame are among the film’s producers, and the voice cast is full of top-flight talent, probably because everyone’s been stuck in lockdown for a year. In addition to Tatum, listen for Simon Pegg, Judy Greer, Bobby Moynihan, Amber Nash, Killer Mike, Andy Samberg, Jason Mantzoukas, Olivia Munn (who, I need to point out, is playing Thomas Edison), Raoul Max Trujillo, Will Forte, and more. The film is slated to come out just before the July Fourth weekend, so I guess it’s time to celebrate.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xKWJcE">
 <strong>How to watch it: </strong><em>America: The Motion Picture</em> will premiere on Netflix.
 </p></li>
 <li><strong>Do we really need influencers’ Israel-Palestine hot takes?</strong> -
 <figure>
 <img alt="" src="https://cdn.vox-cdn.com/thumbor/u4M2DwJHdsluTthf-cedEXstX6M=/38x0:1015x733/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69370790/Screen_Shot_2021_05_28_at_1.37.54_PM.0.png"/>
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 The demand that people with a platform “speak out” on every issue feels misdirected.
 </p>
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 A couple of days ago, <a href="https://www.tiktok.com/@river0fdeceit/video/6964876495261027590"><strong>I saw a TikTok</strong></a> that began as a callout toward creators who were too busy posting goofy videos to speak out on <a href="https://www.vox.com/22430488/israel-gaza-war-2021-hamas-sheikh-jarrah"><strong>the Israeli-Palestinian conflict</strong></a>. Then, abruptly, the video stopped, cutting to another user.
 </p>
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 “You guys want <span class="citation" data-cites="Spencewuah">@Spencewuah</span>?” the second user asked, referring to an example of the type of popular creator the original video was calling out. “What is he gonna say of any fucking substance about the most pressing current event going on right now? If people want to educate themselves they should go to real fucking sources anyway,” she said. “Do you guys even care about the issue or do you care about influencers caring about the issue?”
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 It reminded me of a discussion that I’d been seeing a lot on TikTok about the way social media has given us the expectation that every video, every tweet, every take needs to be a 100 percent irreproachable statement and encompass the lived experiences of everyone who might read it. “The way this app makes us act like teenagers need to have PhD-level expertise on every single topic is crazy,” was the gist of one TikTok I saw months ago and haven’t been able to stop thinking about.
 </p>
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 The same is true, evidently, for influencers. Beyond constant calls in comments sections from their followers to speak up on political issues, even other celebrities have joined the chorus. Earlier this month, the rapper Noname called out famous people who’d stayed silent on the <a href="https://www.vox.com/22453241/biden-blinken-israel-gaza-ceasefire"><strong>latest phase of the conflict</strong></a>.
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 It’s a natural inclination to demand action from the most privileged. The problem is that this desire for others to say something — anything! — feels misdirected. One anonymous beauty influencer <a href="https://graziadaily.co.uk/life/in-the-news/celebrities-influencers-speaking-about-israel-palestine-conflict/"><strong>told the UK fashion magazine Grazia</strong></a> that she’d received DMs from followers telling her they were “disappointed” that she hadn’t spoken up to advocate for Palestinians. She’d read the news but said that to share exactly what she was reading might be considered patronizing to her audience — or worse, end up spreading misinformation. As a woman of color, she also remembered her frustration last summer when non-Black creators kept chiming in about Black Lives Matter. “I didn’t want to be one of those people in this instance,” she said.
 </p>
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 <a href="https://www.tiktok.com/@river0fdeceit" target="_blank" title="@river0fdeceit"><span class="citation" data-cites="river0fdeceit">@river0fdeceit</span></a>
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 <a href="https://www.tiktok.com/tag/greenscreenvideo" target="_blank" title="greenscreenvideo">#greenscreenvideo</a>
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 <a href="https://www.tiktok.com/music/original-sound-6964876353099270917" target="_blank" title="♬ original sound - haley">♬ original sound - haley</a>
 </section>
 </blockquote>
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="17mOF5">
 After enough pressure, however, she shared a link to a news article. That still didn’t satisfy her followers. They told her that “the media wasn’t to be trusted” and sent her other resources instead.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Zh83U5">
 Would there have been a “right way” for a celebrity or influencer who is otherwise unconnected to <a href="https://www.vox.com/policy-and-politics/22442052/israel-palestine-two-state-solution-gaza-hamas-one"><strong>the Israel-Palestine crisis</strong></a> to “speak out”? I’m not entirely sure. As Habiba Katsha <a href="https://www.independent.co.uk/voices/palestine-celebrities-politics-bella-hadid-b1849291.html"><strong>writes in the Independent</strong></a>, “Forcing a group of people who haven’t expressed an interest in social issues to post political content can encourage performative allyship. If influencers are only posting political content because they’ve been told to, it means they’re posting out of obligation rather than desire, which is performative.” She contrasts this to, say, Bella and Gigi Hadid, who as half-Palestinian women have been able to draw on their personal experiences to be vocal about current events. (After they attended a pro-Palestine rally in New York, the <a href="https://www.elle.com/uk/life-and-culture/a36446264/bella-hadid-palestine/"><strong>Israeli government condemned their actions</strong></a> as anti-Semitic.) Israeli actress Gal Gadot also <a href="https://www.hollywoodreporter.com/news/general-news/gal-gadot-israel-palestine-controversy-1234952290/"><strong>drew backlash</strong></a> for her tweets in support of her home country.
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 Many celebrities who have made statements have faced immediate backlash. For weeks, Mark Ruffalo had made clear that his pro-Palestine remarks had nothing to do with anti-Semitism, but after extended pressure, he walked back <a href="https://www.avclub.com/mark-ruffalo-walks-back-his-comments-about-the-israel-p-1846963023"><strong>his original criticisms of Israel</strong></a>. Rihanna, meanwhile, was <a href="https://www.theroot.com/on-rihanna-palestine-and-celebrities-having-the-range-1846884902"><strong>accused of “All Lives Mattering”</strong></a> the issue when she wrote on Instagram that her “heart was breaking with the violence I’m seeing displayed between Israel and Palestine.”
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 The number of people who believe celebrities should “stay out of politics” and the number of those who believe that they should speak up on every platform available is about even, at 29 percent and 28 percent, respectively, according to a <a href="https://morningconsult.com/2018/10/10/hollywood-should-mostly-stay-out-politics/"><strong>2018 poll from Morning Consult and the Hollywood Reporter</strong></a>. Gen Z and millennials <a href="https://morningconsult.com/2018/10/10/hollywood-should-mostly-stay-out-politics/"><strong>are more likely to say</strong></a> that a celebrity speaking out would influence how they vote in an election.
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 Yet the value of these statements should be considered as much as whether the statements should exist at all. For the most part, influencers exist because we like looking at them, their lives, their homes, and their clothes, and not necessarily their ability to articulate nuanced debates. Just as we <a href="https://www.vox.com/recode/22453449/corporate-tax-jeff-bezos"><strong>should be suspicious of any big business</strong></a> that weighs in on political issues, so too should we be of celebrities, because ultimately both are beholden to their own economic success.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9Iququ">
 Rather than share empty <a href="https://www.vox.com/the-goods/21359098/social-justice-slideshows-instagram-activism"><strong>infographics on Instagram</strong></a> or make grandiose statements with little action to back them up, a better way the wealthy could use their platforms is by sharing what, exactly, they’re doing in support of their causes. Reminders from influencers that they engage in activism, that they give a certain percentage of their income to charitable causes, that they volunteer and support their local mutual aid groups, can normalize these activities to the point where more people feel as though we should be regularly incorporating them into our lives.
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 But I don’t know that the demand for influencers to speak out on complex political issues is entirely about the issues themselves. It feels more like a test: Am I, as a fan, justified in having this parasocial relationship with you? Who are you, anyway? Should I be uncomfortable with how much attention we’re all giving you?
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 I can’t help but feel the inevitable anger is similar to what happens when a certain type of always-mad-online person reads a news article about a celebrity wedding or a new fashion trend or, I don’t know, TikTok influencers. They’ll unleash their frustrations over the fact that too much media attention is spent on frivolous-seeming topics and lash out at the writer (“Why don’t you cover something actually important for once?” is a reply every culture reporter repeatedly gets on Twitter). It’s the same kind of misdirection — there are clearly thousands of other reporters covering the topics that said reader has deemed “actually important,” reporters who are far more knowledgeable and well-sourced on such things. Do you really want to read a heady explainer on a new health care bill written by me? Of course you don’t!
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MAn45u">
 Celebrities, in other words, should not be the moral compasses of the masses. We have other people who are supposed to be doing that — for example, political and spiritual leaders who are beholden to us as citizens rather than as consumers. To the extent that those people aren’t doing their jobs is a problem with a solution: Demand better from them, instead of unloading in a beauty influencer’s Ins
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sxXgyz">
 <em>This column first published in The Goods newsletter. </em><a href="https://www.vox.com/pages/newsletters"><em>Sign up here</em></a><em> so you don’t miss the next one, plus get newsletter exclusives.</em>
 </p></li>
 <li><strong>Is it time to rethink the value of college?</strong> -
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 <img alt="" src="https://cdn.vox-cdn.com/thumbor/yVfsOHWiuo09XzVGIEfoTcRfIpU=/329x0:5570x3931/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/69370705/GettyImages_1228201959.0.jpg"/>
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 Students wearing protective masks talk on campus on the first day of classes at Ohio State University in Columbus, Ohio, on August 25, 2020. | Ty Wright/Bloomberg via Getty Images
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 Higher education may not be doomed, but it’s in trouble.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rRZdM1">
 The pandemic hit almost every industry hard, but few were hit as hard as <a href="https://www.nbcnews.com/news/education/crisis-looming-u-s-colleges-not-just-because-pandemic-n1235338">higher education</a>.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="n0z1L9">
 Times were already tough for many American universities, mostly because of <a href="https://www.insidehighered.com/news/2021/03/11/colleges-continue-losing-undergraduate-enrollment-spring-even-graduate-enrollment#:~:text=This%20past%20fall%2C%20undergraduate%20enrollment,decline%20compared%20with%20last%20spring.&amp;text=So%20far%2C%20public%20two%2Dyear,fall%20decline%20in%20the%20sector.">declining enrollment numbers</a> and <a href="https://www.insidehighered.com/news/2020/05/05/public-higher-education-worse-spot-ever-heading-recession">weakening financial support</a> from state governments. The pandemic accelerated these trends and forced colleges — especially smaller private colleges and a ton of midlevel state schools — to gut their budgets and lay off workers to offset revenue losses.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iR0f8Z">
 As we emerge from this pandemic, it’s worth asking what will become of higher education in America. And if the situation is as dire as it appears, should students — and parents — seriously rethink the value of college?
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wr5BPi">
 To get some answers, I reached out to Kevin Carey, who covers higher education for the New York Times, to talk about the state of American colleges. We discuss the <a href="https://www.vox.com/the-highlight/22324143/student-debt-forgiveness-loan-cancellation-economy">student debt crisis</a>, why the pandemic is impacting institutions in wildly disparate ways, what kinds of schools are facing extinction, and if he thinks the future of higher ed in America will look anything like its past.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dc9YdQ">
 A lightly edited transcript of our conversation follows.
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 <h4 id="xtH04e">
 Sean Illing
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pK4eDx">
 Is there an actual crisis in American higher education?
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 Kevin Carey
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M9EIoO">
 Parts of it are facing a crisis. It’s an enormously diverse system with lots of institutions serving different people and goals. If you’re a wealthy university that enrolls wealthy students, times are still pretty great. If you’re a small private college with a small endowment that lives year to year on tuition, these are really tough times. If you’re one of those mid-tier public universities, particularly in states that have pulled back on funding, things are bad.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hrKyM6">
 New undergraduate enrollment is down by about a million and a half students from the peak in the late aughts, which was a high-water mark. We’ve seen income growth remain pretty stagnant for everyone except the well-off, and there just aren’t as many students, and families don’t have enough money to pay tuition. There’s been a real sea change in social attitudes toward debt, and people are (rightly) worried about it.
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 So, yeah, from a pure business standpoint, a lot of colleges are having a hard time making the numbers add up — and that will continue to get worse.
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 Sean Illing
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 What about larger, more prestigious public universities in states that value higher education?
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 Kevin Carey
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 They have problems, but public universities in states that support higher education are doing better. Historically, support for higher education has been a fairly bipartisan or nonpartisan thing in this country. But that’s changed as the electorate has been bifurcated along education and class lines.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vhxV61">
 You can see this after the Great Recession. That was an enormous hit to state budgets. Every state cut funding to its higher education system; one, because they didn’t have as much money, and two, because in recessions, states always disproportionately cut university budgets because universities can raise prices, whereas K-12 schools and prisons can’t. The difference is that some states — like New York and California — put money back into the system as their budgets recovered. Other states, like Louisiana or Pennsylvania, that historically have done a bad job of funding higher ed didn’t put money back in, and those are places that are really struggling.
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 <h4 id="jZjjho">
 Sean Illing
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 Was the pandemic a bigger hit on higher ed than the Great Recession?
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 Kevin Carey
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 We really don’t know yet. The effects of the Great Recession unfolded over the course of five years or so, mostly because the public revenues didn’t snap back for a long time. Traditionally, college enrollment is kind of cyclical. People get laid off and then they’ll go back to get a credential in order to improve their value in the labor market and also because they have the time.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="p3UCW2">
 The pandemic recession was different because it was so fast and so severe, but also weird and unique and it happened so fast. People were going back to school when they were’t ready to go back, and so most of it was online. It was a mess. But things definitely look bad for a lot of colleges right now since enrollment is declining.
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 <h4 id="NHDWk1">
 Sean Illing
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 There are lots of private colleges that are in really dire straits. How many do you think are facing extinction?
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 Kevin Carey
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lfyOkK">
 It’s a good question. Coming up with a precise number is hard, but it’s not a tiny number. Just based on publicly available financial information, you can see that plenty of schools are in danger of going out of business in the next five years or so. Even in the years leading up the pandemic, there has been a steady drip of small private colleges just going bankrupt.
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 A lot of these schools have actually weathered the last year better than I would’ve expected. Overall employment in the higher education sector is down about 15 percent, so I think a lot of institutions took the crisis as an opportunity to lay off people they probably wanted to lay off anyway. I hate to use the phrase “trimming fat” to describe people losing their jobs, but that’s what schools have done to reduce their labor costs.
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 They were also very aggressive about trying to get people back on campus last fall, even when it ran counter to the best interests of public health. But they live and die by enrollment, so they were very adamant about getting people back through the doors. Whether this has a permanent effect on enrollment, I think it’s a little hard to tell at this point.
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 <h4 id="qnFOcC">
 Sean Illing
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0iBhwE">
 Does reducing “labor costs” basically mean firing teachers and gutting liberal arts or humanities problems?
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 Kevin Carey
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SRiWCZ">
 We don’t have those kinds of numbers. Colleges weren’t spending that much money on these things to start with, because not that many students enroll in the humanities. Most of the enrollment is in business, the social sciences, education, and health. There aren’t that many history majors anymore, not like there used to be, anyway. You can hire a history teacher for nothing in the market now because it’s absolutely saturated with people that have the credentials to be college professors. The academic labor market was in a real crisis before the pandemic. Everything that’s happened in the last year has made it worse. I think the hiring will probably accelerate the trend to more contingent faculty, particularly if this big shift to online education continues.
 </p>
 <h4 id="zZpcW2">
 Sean Illing
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 One thing I wonder about is whether the current model can last for much longer, especially in light of the <a href="https://www.vox.com/the-highlight/22324143/student-debt-forgiveness-loan-cancellation-economy">student debt crisis</a>. If people are continually forced to acquire mountains of debt in exchange for the <em>promise</em> of upward mobility, do you feel like we’re going to hit some kind of tipping point where the costs of a degree don’t match the market value and it’s just not feasible for non-wealthy people to attend college anymore? And if that happens, what becomes of higher education?
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 <h4 id="JyD6Zd">
 Kevin Carey
 </h4>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5cYHJz">
 I think the tipping point is more on the institutional side. If people are no longer willing to pay money to certain kinds of colleges, then those colleges will decline and fail. But it’s not that they won’t go anywhere; it’s just that they just won’t go to those places.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jtUL8O">
 The thing is, we have an enormously complicated and highly structured market where there are massive spaces you simply can’t enter without a degree, sometimes even by law. You can’t be a teacher without a degree. Every occupational licensure process is tied to the higher education system. Our entire health system works this way. If you want to be a nurse, you have to go to college. If you want to be part of the professional managerial class, if you want a well-compensated professional life, a stable professional life, you probably have to go to college. And you’re definitely more removed from an acute employment crisis in this economy if you have a college degree.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SmDKjU">
 So I don’t think higher education is going away, but institutions will fail and the market will have to correct.
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 <h4 id="9eFDrJ">
 Sean Illing
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 How much of the turmoil in higher ed is due to the complete embrace of the business mode? So many universities have disinvested in teaching and turned college into a post-adolescent consumer experience. Is that a big part of the story for you?
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 <h4 id="UcvAzm">
 Kevin Carey
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0thYtR">
 Well, there’s only one real model of success in higher education: the academic city-state. It’s the global research university. Everybody wants to be the University of Michigan or something like that. Obviously there’s the Ivy League, but the Ivy League is such a strange and esoteric place. What you really want to be is a big, successful, prosperous institution that has all kinds of smart people and beautiful buildings and sports teams and grassy lawns and football games on Saturdays and social prestige and everyone makes enough money to have a nice little house where they can ride their bike to work. That’s the model of a successful university.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nIKqO8">
 But this is very much a zero-sum game, and everyone’s trying to get there at the same time. There are only so many upper-middle-class students to pay full tuition to support your lazy river and your science center. So there can only be so many University of Michigans. I think a new report came out yesterday that says that private colleges now provide on average about a 54 percent discount against the published tuition price. And that number is going up every year. So they’ve just kind of exhausted their pricing power.
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 If universities play this game and lose, they end up in a tough spot. What we need, from a societal and policy standpoint, is most institutions not trying to be University of Michigan. There shouldn’t be 2,000 research universities in this country. What we need is probably like 300 great research universities and 1,700 universities that are mostly there for teaching. But if status is about research and teaching is just something that you do because you have to, and so therefore you do it as cheaply as possible with basically an indifference to quality, that’s not good for anyone. Including the institution. But that’s where we are right now.
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 <h4 id="19IxyY">
 Sean Illing
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JBmnMs">
 What do you think higher ed looks like in a decade? Does it even resemble its current form?
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 <h4 id="Qn85Qt">
 Kevin Carey
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nVmvSS">
 Lots of institutions that exist today will be gone. There will continue to be attrition and bankruptcy on the private side, probably mergers on the public side. Because almost all the institutions in the bottom half of the distribution of resources and prestige are going to face enormous challenges in terms of their cost structure and the related issues of declining enrollment and a decline in pricing power.
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9saoKx">
 I suspect the long-term trend of more online students will continue as it has for many years. Even before the pandemic, 35 percent of college students were taking at least one online class, and something like 15 percent were totally online. That’s all going to continue. I think you have a relatively small number of institutions that will succeed at that at scale, but most of the colleges that exist now will still exist. Colleges are very resilient historically.
 </p>
 <h4 id="VSbJF2">
 Sean Illing
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 At what point should students and parents seriously reconsider the value of higher education altogether?
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 <h4 id="uJrNHU">
 Kevin Carey
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hSQNOo">
 I think they should think deeply about the value of all of their choices in higher education, because there’s an enormous amount of variance in value. Not all colleges are the same. They don’t charge the same amount of money, they don’t provide the same experience, and your odds of graduating are very different depending on what institution you enroll in.
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 I guess the last thing I’d say is that college has become very high-stakes both from a price standpoint and a value standpoint. So no one should wait to think hard about the value of higher education. The moment is now to take a hard look at all of the choices and not believe all the promises that colleges make. Because they’re making them in their own interest, not in yours.
 </p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Japanese Olympic athletes get vaccine shots as general public lags</strong> - Japanese Olympic Committee official Mitsugi Ogata said the vaccination of young athletes would not affect distribution to the general population, including the elderly and medical workers</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ICC WT20 Rankings: Shafali maintains top spot as Scotland’s Kathryn Bryce enters top-10</strong> - India also has two bowlers in the top-10 list.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Indian boxers to have three-week training camp abroad before Tokyo Olympics</strong> - Indian men’s boxing’s High Performance Director Santiago Nieva said the boxers will reach Tokyo for the Games, five to seven days before the start of the event from July 23.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Birendra Lakra desperate to be in Indian team for Tokyo Olympics</strong> - Lakra, who has played 196 matches for the Indian team, missed out on the Rio Olympics due to a knee injury.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>England tour | Indian players’ families allowed for U.K. trip</strong> - No BCCI office-bearers for World Test Championship final due to quarantine rules</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>CM promises lasting solution for sea erosion</strong> - ‘The issue is of utmost seriousness and extreme erosion had been identified in at least 10 areas’</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Three-day lockdown in Belagavi district</strong> - There will be a complete lockdown in Belagavi district on Friday, Saturday and Sunday to reduce crowds and contain the spread of COVID-19 infection. D</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Post-merger, Syndicate Bank customers told their cheque book is valid only till June 30</strong> - Some customers have expressed concerns over such notifications being sent during the second wave of pandemic</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Yadgir has stemmed second wave, says Deputy Commissioner</strong> - Deputy Commissioner R. Ragapriya has said that the district administration has successfully prevented the spread of COVID-19 in the second wave as the</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NSCN(I-M) using new extremist outfit as front in Assam</strong> - Security forces say arrested ‘army chief’ of Dimasa National Liberation Army revealed links between groups</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
 <ul>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sicilian Mafia: Anger as ‘people slayer’ Giovanni Brusca freed</strong> - Dubbed the “people slayer”, Giovanni Brusca has confessed to his role in more than 100 killings.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Belarus: A climate of fear for opposition activists</strong> - The BBC speaks to some of those whose lives have been changed forever by the protests in Belarus.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Belarus bans most citizens from going abroad</strong> - The travel restriction follows an international outcry over Belarus’s diversion of a Ryanair jet.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NSA spying row: US and Denmark pressed over allegations</strong> - Denmark is accused of helping the US spy on European politicians such as Germany’s Angela Merkel.</p></li>
 <li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Asparagus recipe appears in Belgian law database</strong> - The six-step recipe appears to have been accidentally copied and pasted into a government database.</p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
 <ul>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The US military is starting to get really interested in Starship</strong> - “The Air Force seeks to leverage the current multi-billion dollar commercial investment.” - <a href="https://arstechnica.com/?p=1768781">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The best Memorial Day sales we can find on laptops, video games, and more tech [Updated]</strong> - Including deals on Lenovo ThinkPads, wireless headphones, and PlayStation games. - <a href="https://arstechnica.com/?p=1768406">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Can we keep human inconsistency from confusing expert advice?</strong> - Human variability is great—except when it gets in the way of consistent guidance. - <a href="https://arstechnica.com/?p=1768449">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Genetic tricks of the longest-lived animals</strong> - By studying long-living animals, researchers hope to pinpoint factors affecting human longevity. - <a href="https://arstechnica.com/?p=1768728">link</a></p></li>
 <li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Building a better edible</strong> - Scientists are scouring existing studies and research to learn how edibles interact with the body. - <a href="https://arstechnica.com/?p=1768684">link</a></p></li>
 </ul>
 <h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
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 <li><strong>A boy asked his bitcoin-investing dad for 1 bitcoin for his birthday</strong> - <!-- SC_OFF -->
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 Dad: What? $15,554??? $14,354 is a lot of money! What do you need $16,782 for anyway?
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/Rogitus"> /u/Rogitus </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/npfjys/a_boy_asked_his_bitcoininvesting_dad_for_1/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/npfjys/a_boy_asked_his_bitcoininvesting_dad_for_1/">[comments]</a></span></p></li>
 <li><strong>I met my girlfriend whilst she was working at the zoo.</strong> - <!-- SC_OFF -->
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 There she was in her uniform – straightaway I knew she was a keeper.
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/moosekila"> /u/moosekila </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/npoxbc/i_met_my_girlfriend_whilst_she_was_working_at_the/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/npoxbc/i_met_my_girlfriend_whilst_she_was_working_at_the/">[comments]</a></span></p></li>
 <li><strong>A man in Melbourne walked into the produce section of his local supermarket and asked to buy half a head of cabbage. The boy working in that department told him that they only sold whole heads of cabbage. The man was insistent that the boy ask the manager about the matter…</strong> - <!-- SC_OFF -->
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 Walking into the back room, the boy said to the manager, “Some old bastard outside wants to buy half a head of cabbage.”
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 As he finished his sentence, he turned around to find that the man had followed and was standing right behind him, so the boy quickly added, “…and this gentleman kindly offered to buy the other half.”
 </p>
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 The manager approved the deal and the man went on his way.
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 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 Later, the manager said to the boy, “I was impressed with the way you got yourself out of that situation earlier, we like people who can think on their feet here, where are you from son?”
 </p>
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 “New Zealand, sir.” the boy replied.
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 “Why did you leave New Zealand?” the manager asked.
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 The boy said, “Sir, there’s nothing but prostitutes and rugby players there.”
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 “Is that right?” replied the manager. “My wife is from New Zealand!”
 </p>
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 “Really?” replied the boy. “Who did she play for?”
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/808gecko808"> /u/808gecko808 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/npqab9/a_man_in_melbourne_walked_into_the_produce/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/npqab9/a_man_in_melbourne_walked_into_the_produce/">[comments]</a></span></p></li>
 <li><strong>Studies show that atheists are more likely to own cats than Christians.</strong> - <!-- SC_OFF -->
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 Because owning Christians isn’t legal, obviously.
 </p>
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 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/AmikBixby"> /u/AmikBixby </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/np6i8z/studies_show_that_atheists_are_more_likely_to_own/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/np6i8z/studies_show_that_atheists_are_more_likely_to_own/">[comments]</a></span></p></li>
 <li><strong>A man out shopping bought some new condoms.</strong> - <!-- SC_OFF -->
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 When he got home, his wife noticed the brand. “Olympic condoms? What makes them so special?” she
 </p>
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 asked.
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 “There are three colors,” he replied. “Gold, silver and bronze.”
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 “What color are you going to wear tonight?” she asked.
 </p>
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 “Gold, of course,” said the man.
 </p>
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 “Really?” she said. “Why don’t you wear silver—it would be nice if you came
 </p>
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
 second for a change!”
 </p>
 </div>
 <!-- SC_ON -->
 <p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">  submitted by   <a href="https://www.reddit.com/user/orgasmic2021"> /u/orgasmic2021 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/npms6s/a_man_out_shopping_bought_some_new_condoms/">[link]</a></span>   <span><a href="https://www.reddit.com/r/Jokes/comments/npms6s/a_man_out_shopping_bought_some_new_condoms/">[comments]</a></span></p></li>
 </ul>
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