++A SARS-CoV-2 testing program combining pooled saliva sample surveillance leading to diagnosis and intervention surveyed over 112,000 samples from 18,029 students, staff and faculty, as part of integrative efforts to mitigate transmission at the Georgia Institute of Technology in Fall 2020. Cumulatively, 1,508 individuals were confirmed diagnostically. The surveillance strategy, including focused intensification of testing given case clusters, was effective in disrupting transmission following rapid case increases upon entry in August 2020, and again in November 2020. Owing to broad adoption by the campus community, the program protected higher risk staff while allowing some normalization of research activities. +
++The coronavirus disease 2019 (COVID-19) epidemic in the United States has disproportionately impacted communities of color across the country. Focusing on COVID-19-attributable mortality, we expand upon a national comparative analysis of years of potential life lost (YPLL) attributable to COVID-19 by race/ethnicity (Bassett et al., 2020), estimating percentages of total YPLL for non-Hispanic Whites, non-Hispanic Blacks, Hispanics, non-Hispanic Asians, and non-Hispanic American Indian or Alaska Natives, contrasting them with their respective percent population shares, as well as age-adjusted YPLL rate ratios - anchoring comparisons to non-Hispanic Whites - in each of 45 states and the District of Columbia using data from the National Center for Health Statistics as of December 30, 2020. Using a novel Monte Carlo simulation procedure to quantify estimation uncertainty, our results reveal substantial racial/ethnic disparities in COVID-19-attributable YPLL across states, with a prevailing pattern of non-Hispanic Blacks and Hispanics experiencing disproportionately high and non-Hispanic Whites experiencing disproportionately low COVID-19-attributable YPLL. Furthermore, observed disparities are generally more pronounced when measuring mortality in terms of YPLL compared to death counts, reflecting the greater intensity of the disparities at younger ages. We also find substantial state-to-state variability in the magnitudes of the estimated racial/ethnic disparities, suggesting that they are driven in large part by social determinants of health whose degree of association with race/ethnicity varies by state. +
++We estimated the aggregate prevalence over time for Europe and the Northeast United States to characterize the COVID-19 second surge in these regions. We find a starting date as early as July 3 for Europe and August 19 for the Northeast; subsequent infectious populations that, as of January 07, 2021, have always increased or remained stagnant; and the resurgences being the collective effect of each overall region with no location dominating the dynamics by itself. +
++The COVID-19 pandemic has had severe impacts on global public health. In England, social distancing measures and a nationwide lockdown were introduced to reduce the spread of the virus. Green space accessibility may have been particularly important during this lockdown, as it could have provided benefits for physical and mental wellbeing. However, the effects of public green space use on the rate of COVID-19 transmission are yet to be quantified, and as the size and accessibility of green spaces vary within England9s local authorities, the risks and benefits to the public of using green space may well be context-dependent. To evaluate how green space affected COVID-19 transmission across 98 local authorities in England, we first split case rates into two periods, the pre-peak rise and the post-peak decline in cases, and assessed how baseline health and mobility variables influenced these rates. Next, looking at the residual case rates, we investigated how landscape structure (e.g. area and patchiness of green space) and park use influenced transmission. We first show that pre- and post-peak case rates were significantly reduced when overall mobility was low, especially in areas with high population clustering, and high population density during the post-peak period only. After accounting for known mechanisms behind transmission rates, we found that park use (showing a preference for park mobility) decreased residual pre-peak case rates, especially when green space was low and contiguous (not patchy). Whilst in the post-peak period, park use and green landscape structure had no effect on residual case rates. Our results suggest that a reduction in overall mobility is a good strategy for reducing case rates, endorsing the success of lockdown measures. However, if mobility is necessary, outdoor park use is safer than indoor aggregated activities (e.g. shopping or office-based working), especially during an exponential phase of transmission. +
++In early January 2021, England entered its third national lockdown of the COVID-19 pandemic to reduce numbers of deaths and pressure on healthcare services, while rapidly rolling out vaccination to healthcare workers and those most at risk of severe disease and death. REACT-1 is a survey of SARS-CoV-2 prevalence in the community in England, based on repeated cross-sectional samples of the population. Between 6th and 22nd January 2021, out of 167,642 results, 2,282 were positive giving a weighted national prevalence of infection of 1.57% (95% CI, 1.49%, 1.66%). The R number nationally over this period was estimated at 0.98 (0.92, 1.04). Prevalence remained high throughout, but with suggestion of a decline at the end of the study period. The average national trend masked regional heterogeneity, with robustly decreasing prevalence in one region (South West) and increasing prevalence in another (East Midlands). Overall prevalence at regional level was highest in London at 2.83% (2.53%, 3.16%). Although prevalence nationally was highest in the low-risk 18 to 24 year old group at 2.44% (1.96%, 3.03%), it was also high in those over 65 years who are most at risk, at 0.93% (0.82%, 1.05%). Large household size, living in a deprived neighbourhood, and Black and Asian ethnicity were all associated with higher levels of infections compared to smaller households, less deprived neighbourhoods and other ethnicities. Healthcare and care home workers, and other key workers, were more likely to test positive compared to other workers. If sustained lower prevalence is not achieved rapidly in England, pressure on healthcare services and numbers of COVID-19 deaths will remain unacceptably high. +
++SARS-CoV-2 infection has so far affected over 42 million people worldwide, causing over 1.1 million deaths. With the large majority of SARS-CoV-2 infected individuals being asymptomatic, major concerns have been raised about possible long-term consequences of the infection. We developed an antigen capture assay to detect SARS-CoV-2 spike protein in urine samples from COVID-19 patients whose diagnosis was confirmed by PCR from nasopharyngeal swabs (NP-PCR+). The study used a collection of 233 urine samples from 132 participants from Yale New Haven Hospital and the Childrens Hospital of Philadelphia obtained during the pandemic (106 NP-PCR+ and 26 NP-PCR-) as well as a collection of 20 urine samples from 20 individuals collected before the pandemic. Our analysis identified 23 out of 91 (25%) NP-PCR+ adult participants with SARS-CoV-2 spike S1 protein in urine (Ur-S+). Interestingly, although all NP-PCR+ children were Ur-S-, 1 NP-PCR- child was found to be positive for spike protein in urine. Of the 23 Ur-S+ adults, only 1 individual showed detectable viral RNA in urine. Our analysis further showed that 24% and 21% of NP-PCR+ adults have high levels of albumin and cystatin C in urine, respectively. Among individuals with albuminuria (>0.3 mg/mg of creatinine) statistical correlation could be found between albumin and spike protein in urine. Together, our data showed that 1 of 4 of SARS-CoV-2 infected individuals develop renal abnormalities such as albuminuria. Awareness about the long-term impact of these findings is warranted. +
++While emergence of new SAS-COV-2 variants is posing grave challenge to efforts to deal with the COVID-19 pandemic, the structural and molecular basis of their fitness remain poorly understood. We performed in silico analysis of structures of two most frequent SARS-COV-2 mutations, namely, N501Y and E484K, to identify plausible basis of their fitness over the original strain. The analysis suggested that the N501Y mutation is associated with strengthening of intra- as well as intermolecular H-bond in the hACE2 receptor-spike protein complex, which could result in increased affinity and, therefore, higher infectivity. While E484K mutation did not seem to directly affect the binding with hACE2 receptor, it disrupted H-bonding and salt-bridge interaction associated with binding with neutralizing antibody, which could affect chance of re-infection, disease outcome. Survey of several other mutations showing reduction in antibody-mediated neutralization also revealed that similar disruption of H-bonding or salt-bridge or Van der Waals interaction might explain their phenotype. Analysis of GESS database indicated that N501Y, EK484 as well as these other mutations existed since March-April, 2020, might have evolved independently across the world and may keep accumulating, which could affect efficacy of vaccination and antibody-based therapies. Our analysis also indicated that these may spread in spite of current travel restrictions focused on few countries and evolve indigenously warranting intensification of surveillance for emerging mutations among all travellers as well as people in their dwelling zones. Meta-analysis of existing literature showed that repeat testing of travellers, contacts and others under scrutiny 7-11 days after the initial RT-PCR test may significantly help to contain the spread of emerging variants by catching false negative results. In addition, existing evidence calls for development of strain-specific tests, escalated sequencing and broadening the scope of surveillance including in hospitals and animal farms to contain the threat of emerging variants. +
++In the fight against COVID-19, there remains unmet needs in developing point-of-care (POC) diagnostic testing tools that can rapidly and sensitively detect the causative SARS-CoV-2 virus to control disease transmission and improve patient management. Although recent CRISPR-Cas-assisted SARS-CoV-2 detection assays (such as DETECTR and SHERLOCK) are viewed as transformative solutions for POC diagnostic testing, their lack of simple sample processing and full integration within an automated and portable device hamper their potential for POC use. We report herein POC-CRISPR - a new single-step CRISPR-Cas-assisted assay that is coupled to droplet magnetofluidics (DM) - that leverages simple magnetic concentration and transport of nucleic acid-binding magnetic beads to accomplish sample preparation and assay automation. By further adapting the assay into a fully integrated thermoplastic cartridge within a palm-sized mobile device, POC-CRISPR was able to detect 1 genome equivalent (GE)/μL SARS-CoV-2 RNA from a sample volume of 100 μL in 30 min. Moreover, when evaluated with unprocessed clinical nasopharyngeal (NP) swab eluates, POC-CRISPR identified SARS-CoV-2 positive samples in as short as 20 min and achieved full concordance with standard RT-qPCR. +
++Background: Estimated seroprevalence of Coronavirus Infectious Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) is a critical evidence for a better evaluation of the virus spread and monitoring the progress of the COVID-19 pandemic in a population. In the Kingdom of Saudi Arabia (KSA), SARS-CoV-2 seroprevalence has been reported in specific regions, but an extensive nationwide study has not been reported. Here, we report a nationwide study to determine the prevalence of SARS-CoV-2 in the population of KSA during the pandemic, using serum samples from healthy blood donors, non-COVID patients and healthcare workers (HCWs) in six different regions of the kingdom, with addition samples from COVID-19 patients. Methods: A total of 11703 serum samples were collected from different regions of the KSA including; 5395 samples from residual healthy blood donors (D); 5877 samples from non-COVID patients collected through residual sera at clinical biochemistry labs from non-COVID patients (P); and 400 samples from consented HCWs. To determine the seroprevalence of SARS-CoV-2, all serum samples, in addition to positive control sera from RT-PCR confirmed COVID-19 patients, were subjected to in-house ELISA with a sample pooling strategy, which was further validated by testing individual samples that make up some of the pools, with a statistical estimation method to report seroprevalence estimates Results: Overall (combining D and P groups) seroprevalence estimate was around 11% in Saudi Arabia; and was 5.1% (Riyadh), 1.5% (Jazan), 18.4% (Qassim), 20.8% (Hail), 14.7% (ER; Alahsa), and 18.8% in Makkah. Makkah samples were only D group and had a rate of 24.4% and 12.8% in the cities of Makkah and Jeddah, respectively. The seroprevalence in Saudi Arabia across the sampled areas would be 12 times the COVID-19 infection rate. Among HCWs, 7.5% (4.95-10.16 CI 95%) had reactive antibodies to SARS-CoV-2 without reporting any previously confirmed infection. This was higher in HCWs with hypertension. The study also presents the demographics and prevalence of co-morbidities in HCWs and subset of non-COVID-19 population. Interpretation: Our study estimates the overall national serological prevalence of COVID-19 in Saudi Arabia to be 11%, with an apparent disparity between regions. +
++Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led to poorly defined viral prevalence rates. To address this, we analyzed seropositivity in US adults who have not previously been diagnosed with COVID-19. Individuals with characteristics that reflect the US population (n = 11,382) and who had not previously been diagnosed with COVID-19 were selected by quota sampling from 241,424 volunteers (ClinicalTrials.gov NCT04334954). Enrolled participants provided medical, geographic, demographic, and socioeconomic information and 9,028 blood samples. The majority (88.7%) of samples were collected between May 10th and July 31st, 2020. Samples were analyzed via ELISA for anti-Spike and anti-RBD antibodies. Estimation of seroprevalence was performed by using a weighted analysis to reflect the US population. We detected an undiagnosed seropositivity rate of 4.6% (95% CI: 2.6 - 6.5%). There was distinct regional variability, with heightened seropositivity in locations of early outbreaks. Subgroup analysis demonstrated that the highest estimated undiagnosed seropositivity within groups was detected in younger participants (ages 18-45, 5.9%), females (5.5%), Black/African American (14.2%), Hispanic (6.1%), and Urban residents (5.3%), and lower undiagnosed seropositivity in those with chronic diseases. During the first wave of infection over the spring/summer of 2020 an estimate of 4.6% of adults had a prior undiagnosed SARS-CoV-2 infection. These data indicate that there were 4.8 (95% CI: 2.8-6.8) undiagnosed cases for every diagnosed case of COVID-19 during this same time period in the United States, and an estimated 16.8 million undiagnosed cases by mid-July 2020. +
+Phase III Study of AZD7442 for Treatment of COVID-19 in Outpatient Adults - Condition: COVID-19
Interventions: Drug: AZD7442; Drug: Placebo
Sponsor: AstraZeneca
Not yet recruiting
Fluvoxamine Administration in Moderate SARS-CoV-2 (COVID-19) Infected Patients - Condition: Covid19
Interventions: Drug: Placebo; Drug: Fluvoxamine
Sponsor: SigmaDrugs Research Ltd.
Recruiting
TOCILIZUMAB - An Option for Patients With COVID-19 Associated Cytokine Release Syndrome; A Single Center Experience - Condition: Covid19
Intervention: Drug: Tocilizumab
Sponsor: FMH College of Medicine and Dentistry
Completed
APT™ T3X on the COVID-19 Contamination Rate - Condition: COVID-19
Interventions: Drug: Tetracycline hydrochloride 3%; Drug: Placebo
Sponsors: University of Nove de Julho; Santa Casa de Misericórdia de Porto Alegre
Not yet recruiting
COVID-19 Immunologic Antiviral Therapy With Omalizumab - Condition: Covid19
Interventions: Biological: Omalizumab; Other: Placebo
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Not yet recruiting
An Outpatient Clinical Trial Using Ivermectin and Doxycycline in COVID-19 Positive Patients at High Risk to Prevent COVID-19 Related Hospitalization - Condition: Covid19
Interventions: Drug: Ivermectin Tablets; Drug: Doxycycline Tablets; Drug: Placebo
Sponsor: Max Health, Subsero Health
Recruiting
Safety and Efficacy of Doxycycline and Rivaroxaban in COVID-19 - Condition: COVID-19
Interventions: Drug: Doxycycline Tablets; Drug: Rivaroxaban 15Mg Tab; Combination Product: Hydroxychloroquine and Azithromycin
Sponsor: Yaounde Central Hospital
Recruiting
Phase IIb Clinical Trial of Recombinant Novel Coronavirus Pneumonia (COVID-19) Vaccine (Sf9 Cells) - Condition: COVID-19
Interventions: Biological: Recombinant COVID-19 vaccine (Sf9 cells); Biological: Placebo
Sponsors: Jiangsu Province Centers for Disease Control and Prevention; West China Hospital
Not yet recruiting
Famotidine vs Placebo for the Treatment of Non-Hospitalized Adults With COVID-19 - Condition: Covid-19
Interventions: Drug: Famotidine; Drug: Placebo
Sponsors: Northwell Health; Cold Spring Harbor Laboratory
Recruiting
COVID-19 and Pregnancy: Placental and Immunological Impacts - Condition: Covid19
Intervention: Other: Specimens specific for the study
Sponsor: Hopital Foch
Recruiting
Study to Assess Efficacy and Safety of Inhaled Interferon-β Therapy for COVID-19 - Conditions: Severe Acute Respiratory Syndrome Coronavirus 2; COVID-19
Interventions: Drug: SNG001; Drug: Placebo
Sponsor: Synairgen Research Ltd.
Recruiting
Convalescent Plasma in the Treatment of Covid-19 - Condition: Covid19
Interventions: Biological: Convalescent plasma from COVID-19 donors; Biological: Placebo
Sponsors: Helsinki University Central Hospital; Finnish Red Cross
Recruiting
Early Use of Hyperimmune Plasma in COVID-19 - Condition: Covid19
Intervention: Other: hyperimmune plasma
Sponsors: Catherine Klersy; Policlinico San Matteo Pavia Fondazione IRCCS
Recruiting
Efficacy of Nano-Ivermectin Impregnated Masks in Prevention of Covid-19 Among Healthy Contacts and Medical Staff - Condition: Covid-19
Intervention: Other: ivermectin impregnated mask
Sponsor: South Valley University
Recruiting
Restoration of Endothelial Integrity in Patients With COVID-19 (RELIC) - Condition: COVID-19
Intervention: Biological: Thawed plasma
Sponsor: University of Alabama at Birmingham
Not yet recruiting
Structural basis of SARS-CoV-2 polymerase inhibition by Favipiravir - The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogues, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs by targeting the viral polymerases. However, the underlying mechanisms for the antiviral efficacies of these drugs are far from well understood. Here we reveal that Favipiravir, as a pyrazine derivative, could be incorporated into the viral RNA products...
Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19 - Authors' reply - No abstract
Genetic IL-6R variants and therapeutic inhibition of IL-6 receptor signalling in COVID-19 - No abstract
Efficacy matters: broadening complement inhibition in COVID-19 - No abstract
Efficacy matters: broadening complement inhibition in COVID-19 - Authors' reply - No abstract
Antiviral activity of sulfated polysaccharides from marine algae and its application in combating COVID-19: Mini review - Marine-derived sulfated polysaccharides possess various antiviral activities against a broad range of enveloped and non-enveloped viruses. It has become the potential source of antiviral drugs for pharmaceutical development. In this review, we will discuss the different types of sulfated polysaccharides and their structural classification. Some of the major sulfated polysaccharides with potent antiviral activity, including carrageenan, agar, ulvan, fucoidan, and alginates, are considered in this...
Hypoxia-inducible factor (HIF): The link between obesity and COVID-19 - The COVID-19 death toll has involved to date more than 1 million confirmed deaths. The death rate is even higher in the obese COVID-19 patients, as a result of hypoxia, due to the interplay between adipose tissue hypoxia and obstructive sleep apnea. The discrepancy of manifestations seen in COVID-19 seems to be mediated by a differential immune response rather than a differential viral load. One of the key players of the immune response is HIF. HIF-1β is a stable constitutively expressed protein...
Manipulated bio antimicrobial peptides from probiotic bacteria as proposed drugs for COVID-19 disease - Coronavirus disease 19 (COVID-19) is the latest pandemic resulted from the coronavirus family. Due to the high prevalence of this disease, its high mortality rate, and the lack of effective treatment, the need for affordable and accessible drugs is one of the main challenges in this regard. It has been proved that RdRp, 3CL, Spike, and Nucleocapsid are the most important viral proteins playing vital roles in the processes of proliferation and infection. Therefore, we started studying a wide...
Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach - CONCLUSION: Our study highlights the potential of existing mushroom-derived natural compounds for further investigation and possibly can be used to fight against SARS-CoV-2 infection.
Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection - BACKGROUND AND AIM: The novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now become a worldwide pandemic bringing over 71 million confirmed cases, while the specific drugs and vaccines approved for this disease are still limited regarding their effectiveness and adverse events. Since virus incidences are still on rise, infectivity and mortality may also rise in the near future, natural products are highly considered to be valuable...
Molecular docking analysis of rutin reveals possible inhibition of SARS-CoV-2 vital proteins - BACKGROUND AND AIM: COVID-19 emerged by the end of 2019 in Wuhan, China. It spreaded and became a public health emergency all over the world by mid of April 2020. Flavonoids are specialized metabolites that have antimicrobial properties including anti-viral activity. Rutin, a medicinally important flavonoid belongs to one of the best natural antioxidant classes. It has antiprotozoal, antibacterial, and antiviral properties. Keeping the antimicrobial potential of rutin in mind, we studied its...
FDA Recommended Potent Drugs against Covid-19: Insight through Molecular Docking - Human Coronavirus (COVID-19) is a worldwide pandemic of 2019-20 that was emerged in China in December, 2019. More than 37,000deaths with7, 84, 440confirmed cases has been reported from around 200 different countries has been reported till now and the number is increasing every second. The spread is said to be throughhuman to human transmission via close contact or respiratory droplets produced when people cough or sneeze. No treatment for the illness has been approved yet. The urgent need is to...
Random forest regression analysis on combined role of meteorological indicators in disease dissemination in an Indian city: A case study of New Delhi - Meteorological parameters show a strong influence on disease transmission in urban localities. The combined influence of factors such as daily mean temperature, absolute humidity and average wind speed on the attack rate and mortality rate of COVID-19 rise in Delhi, India has been investigated in this case study. A Random forest regression algorithm has been utilized to compare the epidemiological and meteorological parameters. The performance of the model has been evaluated using statistical...
Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites - There are numerous trials underway to find treatment for the COVID-19 through testing vaccines as well as existing drugs. Apart from the many synthetic chemical compounds, plant-based compounds could provide an array of candidates for testing against the virus. Studies have confirmed the role of many plants against respiratory viruses when employed either as crude extracts or their active ingredients in pure form. The purpose of this review article is to highlight the importance of...
Two Pronged Approach for Prevention and Therapy of Covid-19 (Sars-CoV-2) by a Multi-targeted herbal Drug, a component of Ayurvedic decoction - CONCLUSION: : The resultant compound could act as a repurposed drug or like other methoxyphenols, could be a good lead molecule for a potent drug for Covid-19.
METHOD AND APPARATUS FOR ACQUIRING POWER CONSUMPTION IMPACT BASED ON IMPACT OF COVID-19 EPIDEMIC - - link
A PHARMACEUTICAL COMPOSITION OF ARTESUNATE AND MEFLOQUINE AND METHOD THEREOF - A pharmaceutical composition for treating Covid-19 virus comprising a therapeutically effective amount of an artesunate or its pharmaceutically acceptable salts thereof and a mefloquine or its pharmaceutically acceptable salts thereof is disclosed. The pharmaceutical composition comprises the artesunate in the ratio of 0.25% to 66% w/v and mefloquine in the ratio of 0.25% to 90% w/v. The composition is found to be effective for the treatment of COVID -19 (SARS-CoV2). The pharmaceutical composition of Artesunate and Mefloquine has been found to be effective and is unexpectedly well tolerated with a low rate of side-effects, and equally high cure-rates than in comparable treatments. The present invention also discloses a method to preparing the pharmaceutical composition comprising of Artesunate and Mefloquine. - link
+
Zahnbürstenaufsatz für eine elektrische Zahnbürste (20) umfassend einen Koppelabschnitt (2), über den der Zahnbürstenaufsatz (1) mit einer elektrischen Versorgungseinheit (10) der elektrischen Zahnbürste (20) verbindbar ist und einen Bürstenabschnitt (3), der zur Reinigung der Zähne ausgebildete Reinigungsmittel (3.1) aufweist, dadurch gekennzeichnet, dass an dem Zahnbürstenaufsatz (1) eine Sensoreinheit (4) vorgesehen ist, die dazu ausgebildet ist, selektiv das Vorhandensein eines Virus oder eines Antigen im Speichel eines Nutzers des Zahnbürstenaufsatzes (1) durch Messen zumindest eines virusspezifischen Parameters zu bestimmen.
COVID-19 CLASSIFICATION RECOGNITION METHOD BASED ON CT IMAGES OF LUNGS - - link
+
Vorrichtung (10) umfassend einen Schutzschirm (12) und einen Filter (14) zum Herausfiltern von Viren (16) aus einem Schall erzeugenden Luftstrom (18), der von einem Musiker (20) beim Musizieren mit einem Musikinstrument oder beim Singen erzeugt wird, wobei der Schutzschirm (12) zur Verringerung des Risikos einer Infektion mit den Viren (16) dafür vorgesehen ist, wenigstens einen Teil der mit dem Luftstrom transportierten Viren (16) aufzufangen, der Schutzschirm (12) eine erste Seite (22) und eine zweite Seite (24) aufweist, die voneinander abgewandt sind, und der Schutzschirm (12) wenigstens einen sich von der ersten (22) bis zu der zweiten Seite (24) erstreckenden Durchlass (26) aufweist, wobei dieser Durchlass (26) zum Durchströmen mit wenigstens einem Teil des beim Musizieren erzeugten Luftstroms (18) vorgesehen ist und der Filter (14) zum Herausfiltern von Viren (16) aus dem Luftstrom (18) in dem Durchlass (26) des Schutzschirms (12) angeordnet ist.
+Seil-Haltevorrichtung (1)
mit einer Seil-Klemmeinrichtung (3), die auf dem Träger (2) angeordnet ist.
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
Covid 19 - Chewing Gum - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
+
Die Erfindung betrifft ein Fahrzeuglüftungssystem (1) zum Belüften einer Fahrgastzelle (2) eines Fahrzeugs (3), mit einem Umluftpfad (5). Die Erfindung ist gekennzeichnet durch eine wenigstens abschnittsweise in einen Umluftansaugbereich (4) des Umluftpads (5) hineinreichende Sterilisationseinrichtung (6), wobei die Sterilisationseinrichtung (6) dazu eingerichtet ist von einem aus der Fahrgastzelle (2) entnommenen Luftstrom getragene Schadstoffe zu inaktivieren und/oder abzutöten.
Biden’s Pandemic Plan Might Just Work - The coronavirus is devastating America, and getting worse—but it’s not too late for a concerted effort to save countless lives. - link
The GameStop Stock Saga Is Dangerous and All Too Familiar - As the Federal Reserve surely knows, the longer that speculative bubbles are allowed to inflate, the bigger the eventual bust, and the more negative fallout there is for the economy as a whole. - link
The Biden Administration’s Landmark Day in the Fight for the Climate - The newly announced actions may well mark the beginning of the end of the fossil-fuel era. - link
The Coronavirus Vaccine Presents a Dilemma for Pregnant Women - Vaccine trials have excluded the pregnant population, even though women of reproductive age make up a majority of frontline workers. - link
The Three Biggest Lessons of the Coronavirus Economy - Nearly a year into the pandemic, solving the economic crisis means defeating the virus. - link
++If Democrats agreed to the proposal, they would be able to pass bipartisan relief via the normal voting process. +
++A group of 10 Republican senators sent a letter to President Joe Biden on Sunday proposing a smaller coronavirus relief package than his $1.9 trillion plan, and asking him to negotiate with them to find compromise on the issue of new Covid-19 stimulus efforts. +
++The number of signatories is significant, because any bill taken up under normal Senate rules would need at least 10 GOP backers in order to be successful. This renders the letter, in effect, an offer to work with Democrats to pass new stimulus measures — with certain conditions. +
++In the letter, the Republican lawmakers — a group that includes Sens. Mitt Romney of Utah, Susan Collins of Maine, and Lisa Murkowski of Alaska, as well as other relative moderates — argued their proposal, which they promised to release in full on Monday, would be able to receive bipartisan support, given that it mirrors Biden’s call for $160 billion for coronavirus testing, tracing, treatment, and protective supplies. +
++The lawmakers also said their bill will include funding for direct payments to “families who need assistance the most,” a reference to some lawmakers’ desire to needs-test direct payments; assistance for small businesses and child care; and $4 billion for mental health and substance use. +
++They did not provide specifics, but the Washington Post reports the GOP proposal would cut the cost of new stimulus by $1.3 trillion, to around $600 billion, and that it would do so by making major cuts to a number of Democratic priorities. +
++For instance, Democrats have pushed for another round of direct payments of $1,400 to single people making $75,000 or less per year, and to couples making $150,000 or less. As Sen. Bernie Sanders pointed out on ABC’s This Week Sunday, Democrats promised there would be another round of direct payments of at least $1,400 if they won both Senate seats in January’s Georgia runoff races — and they did. +
++“You can’t campaign on a series of issues, and then, after the election, when you get power, say, ‘Oh, well, you know what, we’re changing our mind,’” Sanders said. +
++Accepting the new Republican proposal would force Democrats to do just that, however — it would reduce the direct payments to $1,000 per person, the Post reports. +
++And those payments would likely be sent out to a much smaller group of people under the new Republican plan. Ohio Sen. Rob Portman, one of the letter’s signatories, said on CNN’s State of the Union Sunday that direct payments should be capped at individuals earning $50,000, or families earning $100,000. “Let’s focus on those who are struggling,” Portman said. +
++++A group of GOP senators, including Sen. Rob Portman, sent a letter to President Biden proposing their own Covid-19 relief package framework and asking to work together.
+— State of the Union (@CNNSotu) January 31, 2021 +
“We need to be sure this is targeted,” Portman says. https://t.co/iFpCBrgsrH #CNNSOTU pic.twitter.com/4wycNDmQO8 +
+Portman also said that the Democratic proposal to extend federal unemployment insurance — currently valued at $300 per week — through September was premature, and that that program should also be better targeted. +
++Democrats have proposed not just extending that program, but expanding it, by bumping up weekly payments to $400. The Post reports that the GOP plan envisions keeping the weekly allowance at $300, and extending the program, currently set to expire in March, until June. +
++The GOP plan also reportedly gets rid of the Democratic proposal to raise the federal minimum wage to $15 per hour, and would likely reduce the amount of aid available to state and local governments. +
++The GOP signatories argue in their letter — and in television appearances Sunday — that their proposal will give Biden a chance to make good on his promise for “unity,” a theme of his inaugural address. +
++“In the spirit of bipartisanship and unity, we have developed a COVID-19 relief framework that builds on prior COVID assistance laws, all of which passed with bipartisan support,” the letter reads. “We request the opportunity to meet with you to discuss our proposal in greater detail and how we can work together to meet the needs of the American people during this persistent pandemic.” +
++And they claim that Democrats’ current plans to push their preferred proposal through Congress through a process known as reconciliation, which allows for legislation related to budgetary matters to be passed in the Senate with a simple majority vote (a majority Democrats now have due to their victories in Georgia), would — in Portman’s words — “poison the well” for any future attempts at bipartisan legislating. +
++State of the Union host Dana Bash asked Portman why he had supported Republicans using reconciliation to advance controversial legislation in the past, noting it had been used both in the Republican effort to destroy the Affordable Care Act and to pass Trump’s tax cuts into law. Portman replied that “reconciliation is not meant for the purposes that they are trying to use it for,” and argued Democrats should not use reconciliation as their first resort. +
++Democrats, however, have long been stymied in their efforts to pass a sweeping stimulus package, agreeing to a compromise bill in late 2020 after months of Republican refusals to consider a $3 trillion bill that passed the House in May 2020. +
++Senate Majority Leader Chuck Schumer has said he is willing “to work with our Republican colleagues to advance” coronavirus relief, but that Democrats are “keeping all our options open, on the table, including budget reconciliation.” +
++What reception the new GOP proposal will receive from Biden remains to be seen. Appearing on State of the Union on Sunday, the director of the National Economic Council, Brian Deese, told Bash, “We welcome input to say where we may have not gotten everything right,” but argued, “The cost of doing too little right now far outweighs the cost of doing too much.” +
++Given that many federal coronavirus programs are set to expire in the coming months, there is a need for urgency in work on the next round of stimulus. As Vox’s Emily Stewart has reported, delays in passing the last round meant coverage gaps for many of the unemployed. +
++Friday, Biden stressed the importance of getting a coronavirus stimulus bill passed, saying, “I support passing Covid relief with support from Republicans if we can get it, but the Covid relief has to pass. There are no if, ands, or buts.” +
++++Biden on if he supports passing Covid relief through budget reconciliation: "I support passing Covid relief with support from Republicans if we can get it, but the Covid relief has to pass. There are no if, ands, or buts." pic.twitter.com/rm4etycvKb +
+— Aaron Rupar (@atrupar) January 29, 2021 +
+Given the House’s Democratic majority, and the fact that legislation can pass in that chamber by a simple majority vote, the Senate is where any difficulty in quickly passing aid will arise. There, Democrats have been faced with either finding 10 Republicans to support their proposal, compromising with moderate Republicans on a plan like that advanced by the 10 GOP senators on Sunday, or passing legislation through reconciliation. +
++For any of these routes to work in the Senate, Democrats would need to be a united front. As it stands, they hold the narrowest possible majority in the evenly-split Senate, with Vice President Kamala Harris serving as a tie-breaker. +
++And a united front is not a given, because there are some right-leaning Democrats in the Senate who have not fully embraced all the proposals in Biden’s plan, something that ABC’s Martha Raddatz asked Sanders about on Sunday. +
++Specifically, she asked Sanders about West Virginia’s Joe Manchin, who has said that bipartisan lawmaking is important to him and who has not offered full-throated support of a $15 minimum wage. He has also not said whether he would go along with Democrats if they choose to pursue reconciliation. Sanders expressed faith that “all Democrats understand the need to go forward” with coronavirus relief. +
++++“I believe that we do,” Sen. Bernie Sanders tells @MarthaRaddatz when asked if Democrats have enough votes to pass the COVID-19 relief bill.
+— This Week (@ThisWeekABC) January 31, 2021 +
Despite “differences and concerns” about the bill, the American people need relief, he adds. https://t.co/0tIupXQlob pic.twitter.com/aGbtmRQ7b1 +
+“The question is not bipartisanship, the question is how to address these crises right now,” said Sanders. “If Republicans want to work with us, they have better ideas on how to address those crises, that’s great. But to be honest with you, I have not yet heard that.” +
++Sanders added that there would be other opportunities for bipartisanship in the future, especially around issues like prescription drug reform and infrastructure. “But right now, this country faces an unprecedented set of crises,” he said. +
++One of the GOP letter’s signatories, Louisiana Sen. Bill Cassidy, suggested Sunday that Republicans hadn’t been given enough of a chance to work on a bipartisan agreement. +
++“If you want unity, you want bipartisanship, you ought to start with the group that’s willing to work together,” Cassidy said on Fox News Sunday. +
++As Republicans have pointed out, Biden has stated a desire to work with Republicans on legislation. But as Vox’s Ella Nilsen has written, Biden’s ambitions to work across the aisle and to pass his relief package may be at odds with one another — particularly given the more limited scale of relief the 10 GOP senators now propose. +
++And Democrats seem to believe that if they can only fulfill one of the president’s ambitions, the priority is on getting the package done. As Nilsen writes: +
++++While Republicans in the bipartisan group are the ones advocating for cutting back on Biden’s Covid-19 bill, Democratic senators in the centrist group haven’t been as eager to scale back. Democrats remember that Senate Republicans used the budget reconciliation mechanism to pass their massive tax cut bill in 2017, and some in the Democratic caucus think they should give their priorities the same treatment now that they hold the majority. +
++Sanders, the Senate Budget Committee chair, and House Budget Committee Chair John Yarmuth have each told reporters their committees are working on drafting budget reconciliation resolutions for the Covid-19 relief bill, which could pass in a matter of days if Schumer and House Speaker Nancy Pelosi give them the green light. +
+
+Those reconciliation resolutions are now expected as early as this week. Republicans can also sign onto them if they so desire. +
+
++The head of Trump’s impeachment defense team has left; his exit was followed by several others. +
++With just over a week until his Senate impeachment trial, former President Donald Trump’s defense team is disintegrating, with at least five lawyers departing or declining to join it, including a South Carolina attorney selected just last week to lead the defense effort. +
++That attorney, Karl “Butch” Bowers Jr., will no longer represent Trump when the former president faces the Senate on February 9 over his alleged role in inciting the violent insurrection at the US Capitol. Politico reports that Bowers and another South Carolina-based attorney, Deborah Barbier, were confirmed on Saturday to have departed from the team. +
++CNN’s Kaitlan Collins then reported on Saturday night that lawyer Josh Howard, a recent addition to the defense effort, also would not be part of the team. +
++These resignations came, Collins’s sources said, because “Trump wanted the attorneys to argue there was mass election fraud and it was stolen from him rather than focus on proposed arguments about constitutionality.” +
++Finally, two other South Carolina attorneys who reportedly planned to be part of Trump’s team, Johnny Gasser and Greg Harris, have exited as well, according to the New York Times. +
++The news comes after Trump reportedly struggled to find lawyers to represent him. +
++Oral arguments are due to begin on February 9, a date chosen after some negotiation among party leaders. House Democrats serving as impeachment managers have their first filing in the proceedings due on Tuesday. Trump has until the day before the arguments begin to file his briefs. +
++Bowers, who previously successfully defended former South Carolina Gov. Mark Sanford in a 2009 impeachment hearing, was considered a measured alternative to the more bombastic Rudy Giuliani, Trump’s longtime attorney who oversaw the Trump campaign’s failed attempts to overturn the 2020 election results in court. +
++Giuliani had suggested that he might lead Trump’s defense, after representing Trump during a special counsel investigation into his 2016 campaign. However, he later said he can’t represent Trump in this case, as his presence at the Trump rally that proceeded the insurrection makes him a “witness.” +
++The departure of Barbier and Bowers was described to Politico as a “mutual decision.” Trump reportedly did not feel that he had chemistry with Bowers, “a quality the former president generally prizes in his relationships,” reported the Times’s Maggie Haberman. Additionally, Bowers does not maintain a significant media presence, another quality that Trump likes in his lawyers, according to Haberman. +
++Bowers is a longtime friend of Sen. Lindsey Graham, who first announced the hiring during a Senate GOP meeting on January 21. At the time, Graham suggested that the defense’s legal strategy might hinge on the idea that the impeachment proceedings should be considered unconstitutional, coming, as they will, weeks after Trump left office. +
++However, as Vox’s Ian Millhiser has explained, a majority of legal scholars say that holding an impeachment trial for a former president would be constitutional. Nevertheless, following the dissolution of Trump’s legal team, a spokesperson for the president again made the claim that the trial is unconstitutional, while also saying that Trump’s defense is still being finalized. +
++“The Democrats’ efforts to impeach a president who has already left office is totally unconstitutional and so bad for our country,” Trump spokesperson Jason Miller said. “In fact, 45 senators have already voted that it is unconstitutional. We have done much work, but have not made a final decision on our legal team, which will be made shortly.” +
++Here, Miller was referring to a motion led by Sen. Rand Paul of Kentucky last Tuesday to force a vote on whether impeaching a former president would be constitutional. Paul, who has declined to admit that the November election was not stolen, was attempting to demonstrate that there will not be sufficient GOP support for conviction. +
++An impeachment trial conviction requires the support of two-thirds of the Senate, which means at least 17 Republicans would need to vote in favor of convicting Trump for the effort to be successful. There is little indication that many GOP senators will be willing to do so. +
++It is not clear who will now step up to represent Trump in the historic proceedings, which come after he was impeached in the House on January 13 for “incitement of insurrection,” after a mob of his supporters violently attacked the US Capitol building shortly after a Trump-led rally on January 6. The attack left five people, including a Capitol Police officer, dead. +
++Giuliani has said he cannot. And Trump’s lawyers from his first impeachment, including former White House counsel Pat Cipollone and Jay Sekulow, have signaled that they will not represent him in this one. +
++Even as Trump works to quickly reassemble his legal team, Democrats are moving full speed ahead with their prosecution. +
++According to the Washington Post, House Democrats have made plans to bring evidence linking Trump to the injuries sustained by police officers during the insurrection, and are using cell phone footage taken on January 6 to “build an emotionally compelling impeachment case.” +
++At least 140 Capitol Police officers were injured during the day’s events, according to their union. One is in danger of losing an eye, one was stabbed with a metal fence stake, and others have suffered spinal and brain damage, Gus Papathanasiou, the chair of the Capitol Police Labor Committee, said this week. +
++One officer died from injuries sustained during the attack, and two other police officers who responded to the attack have died by suicide in the days since. Four of the rioters also died on January 6; one was shot by police, while three others died in separate medical emergencies, according to DC Metropolitan Police at the time. +
++Democrats appear poised to use video evidence of the day’s dramatic and bloody events to make the case that it was Trump who incited this level of violence, and that he did so in an undemocratic attempt to maintain his hold on the presidency. +
++Democrats may also attempt to leverage the fact that members of Congress and their staffs were witnesses to the storming of the Capitol, and are reportedly considering calling police officers who tried to repel the insurrectionists to testify as witnesses. +
++As painstaking as Democrats’ preparations are, and as chaotic as Trump’s have been, for many observers it is all but a foregone conclusion that Trump will not be convicted. +
++While a handful of Senate Republicans have been critical of Trump in the wake of the attempted coup, most still support the former president, and have either signaled or said outright that they will not vote to convict. Many do not believe the proceedings should be allowed to go forward at all. +
++Both parties have suggested that they want the trial to be speedy — preferably lasting a week — as the country continues to face down a roiling pandemic and related economic calamity. However, the trial may not be the end of potential consequences for Trump’s role in attempting to overturn the election: If the Senate does not vote to convict, Democrats are also beginning to weigh a censure resolution, proposed by Sen. Tim Kaine of Virginia. +
++
+
++The skit investigated Rep. Marjorie Taylor Greene, GameStop, social media, Covid-19, and Tom Brady. +
++After a year that seemed to last a decade, the month of January has somehow also managed to pack a lifetime’s worth of major historic events into a few weeks. +
++That was the premise of Saturday Night Live’s cold open for its January 30 show, which featured a spoof of gentle morning talk shows, called What Still Works? +
++Kate McKinnon played the host, and began the segment with the question: “It’s a new year and we have a new president, so some things should work. But do they?” +
++A range of characters came out to answer that question by speaking on topics including politics, finance, technology, and health — each touching on the fact that in the past few weeks, a new Congress has been sworn in, there was an attempted insurrection at the US Capitol, former President Donald Trump became the first president to be impeached twice, an internet community helped drive a major stock market squeeze, and the pandemic continues to take thousands of lives per day. +
++Out first was QAnon adherent Rep. Marjorie Taylor Greene (played by Cecily Strong) to talk about the government. McKinnon prompted her to review her week, which included the surfacing of previous incorrect statements, ranging from her claim that California’s 2018 forest fires were caused by Jewish-controlled space lasers to her suggestions that school shootings aren’t real. +
++“And those are real things you believe and tell other people about? And you’re a US representative?” McKinnon asked, to which Strong replied, “Mmhm, yep.” +
++“People can Google you and it’ll say, ‘She’s a real member of the US government?’” McKinnon asked. +
++“That may not be the first thing that comes up, but yes,” Strong replied. +
++“So, government doesn’t work,” McKinnon concluded. +
++Next, McKinnon turned to talking about the stock market. “That usually works, right? That’s where people invest all their retirement money, so it should probably work.” +
++Out came Pete Davidson as Derrick Boner, introduced as the new majority shareholder of GameStop. This week, that company saw its share prices soar after an army of small investors, largely encouraged by a Reddit forum, turned that stock into a valuable meme. +
++When asked if the stock market still works, Davidson — attired in a GameStop shirt, an enormous gold chain, and a a gaudy wristwatch — replied, “Hell yeah.” +
++But McKinnon questioned whether GameStop, which currently relies on an increasingly obsolete business model at a time when many people download or stream games, will be able to maintain its sky-high share prices. +
++“So now it seems like — ” she prompted Davidson. +
++“The entire system is a joke?” he replied. +
++“Exactly,” she said. “So, the stock market no longer works.” +
++Next, McKinnon questioned Twitter CEO Jack Dorsey (played by Mikey Day), and Facebook CEO Mark Zuckerberg (played by Alex Moffat), quickly concluding that social media is broken, too, after each reflected on the role the major tech platforms played in amplifying far-right voices ahead of the violent siege of the Capitol. +
++In focusing on the Covid-19 vaccine rollout, McKinnon brought out Kenan Thompson as O.J. Simpson, who received an inoculation this week. +
++“Get your shot. I got mine!!!” the 73-year-old, whose age puts him in his state’s priority group, posted on Twitter on Friday. The post drew backlash from some who felt the former football star was getting special treatment, as millions of vulnerable Americans still have not received theirs amid a bumpy and disorganized distribution scheme. +
++“Teachers can’t get vaccines, but you did? People with long-term lung conditions can’t get the vaccine, but you did?” McKinnon asked. “Among the first 3 percent of Americans given the vaccine was O.J. Simpson?” +
++“Hey, guilty as charged,” Thompson’s Simpson laughed. “About the vaccine!” +
++Finally, McKinnon brought out Tampa Bay Buccaneers quarterback Tom Brady, played by the show’s host, John Krasinski. +
++“You might be the only thing in America that still works,” McKinnon said. “So I guess everyone must be rooting for you, right?” +
++“Almost no one,” Krasinski replied. +
++McKinnon said she’d root for him, because “it’s not like you’re a weird Trump guy or anything, right?” +
++Brady has long faced such questions over his relationship with Trump, and at that, Krasinski left. +
++McKinnon ended the segment by joking that she’s been “slowly losing my mind with all of you,” and with a more sober acknowledgment that amid all the news, it is okay to sometimes feel overwhelmed. +
+50% crowd for 2nd India-England Test; media also allowed to cover from press box - The issue was discussed by the TNCA members after fresh COVID-19 guidelines on easing of public movement and entry of spectators into sporting venues were issued
100th Test at Chennai is very special: Root - England skipper talks about the milestone and how it all began in India in 2012
La Liga | Messi hits goal 650 as Barcelona get revenge on Athletic - Ronald Koeman's Barca side saw out the game to record a fifth straight Liga victory.
Syed Mushtaq Ali Trophy | No stopping Tamil Nadu - Siddharth spins a web around the Baroda batsmen
Possibility of fans being allowed for second Test - ‘Good possibility’ of spectators being allowed for second Test
Watch | Highlights of Union Budget 2021 - A video on the highlights from the Budget Speech 2021-22 of Finance Minister Nirmala Sitharaman.
Order on Sivasankar’s bail plea on Wednesday - The Economic Offences Court, Ernakulam, will pronounce its order on the bail application of M. Sivasankar, former Principal Secretary of Chief Ministe
Union Budget disappointing for salaried class, says TN government transport staff federation - The Union Budget 2021-22 has been a big disappointment to the salaried class with no relief given in income tax, said joint secretary of Tamil Nadu Go
Portal to collect data on gig workers in Budget - It helps in formulating health, housing, skill, insurance, credit and food schemes for migrant workers, says Minister
Punjab Mail diverted, another train short-terminated amid charges farmers denied reaching Delhi - Sources said that a group of farmers had boarded the Punjab Mail last night at Ferozepur (in Punjab) and they were to join others who have been protesting against the Central laws
Austria Covid: Brits among 96 skiers quarantined in St Anton - Police say they found the foreigners breaking Covid-19 rules by staying in the St Anton ski resort.
Covid: EU and AstraZeneca in 'step forward' on vaccines - The Commission chief announces a "step forward" after criticism over EU handling of vaccine plans.
Navalny protests: Thousands across Russia join demonstrations - More than 5,000 people are arrested amid demonstrations for the jailed opposition leader.
Ryanair forecasts 'strong return' of beach holidays this summer - Boss Michael O'Leary thinks travel restrictions will be dropped once high risk groups are vaccinated.
Ancient Jersey teeth find hints at Neanderthal mixing - A re-study of the prehistoric find from 1910 suggests interbreeding between two human species.
Hedge fund Melvin sustains 53% loss after Reddit onslaught - $4.5 billion drop in assets after bets against the likes of GameStop go sour. - link
Multi-layered Outside the Wire is part action thriller, part intimate drama - Director Mikael Håfström on making a military action movie that is ultimately anti-war. - link
An electric race car has lapped Daytona for the first time - We may well see an electric touring car series in the US in the next few years. - link
A curious observer’s guide to quantum mechanics, pt. 4: Looking at the stars - How do photons travel across light years? (Their quantum waviness enables modern telescopes.) - link
New study: A zero-emissions US is now pretty cheap - In 2050, benefits to the US offset costs, but there are some unexpected outcomes. - link
+It's so deep that they can’t see the bottom. One hunter goes looking for something to throw down the hole hoping to see how deep it is. +
++He finds a rusty old anvil near by and throws it down the hole. The hole is so deep they never hear it hit the bottom. +
++Suddenly, they hear speeding hooves behind them and a goat goes flying past them and jumps right into the hole. +
++A few seconds later, they hear a farmer calling out for his goat. "Betsy! Betsy!" +
++He sees the two hunters and asks if they had seen his goat Betsy."Yeah", they say, "She ran right passed us at like 80 miles and hour and jumped right into this hole!" +
++“That’s impossible, the man says, "I had her chained to an anvil! ” +
++ +
++(Not mine, just thought I'd share) +
+ submitted by /u/zaqwert6
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+It scares the shit out of their dogs. +
+ submitted by /u/spaceman190207
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+He opens the door and there is a young man standing there. +
++"Hello. My name is Tobias. I'm here to fuck your daughter." +
++The man can't believe his ears: "To what?!" +
++"Tobias" +
+ submitted by /u/Sycod
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+She said it was disgusting to let my grandma touch me like that. +
+ submitted by /u/mrbadassmotherfucker
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+When I was born, god gave me the option between choosing the ability to finish stories, or having a big dick. +
++Obviously, I chose +
+ submitted by /u/Shadowzer
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