diff --git a/archive-covid-19/31 March, 2021.html b/archive-covid-19/31 March, 2021.html new file mode 100644 index 0000000..e56f3d4 --- /dev/null +++ b/archive-covid-19/31 March, 2021.html @@ -0,0 +1,215 @@ + +
+ + + ++Vaccination and non-pharmaceutical interventions (NPIs) reduce transmission of SARS-CoV-2 infection, but their effectiveness depends on coverage and adherence levels. We used scenario modeling to evaluate their effects on cases and deaths averted and herd immunity. NPIs and vaccines worked synergistically in different parts of the pandemic to reduce disease burden. +
++The five boroughs of New York City (NYC) were early epicenters of the Covid-19 pandemic in the United States, with over 380,000 cases by May 31. High caseloads were also seen in nearby counties in New Jersey (NJ), Connecticut (CT) and New York (NY). The pandemic started in the area in March with an exponential rise in the number of daily cases, peaked in early April, briefly declined, and then, showed clear signs of a second peak in several counties. We will show that despite control measures such as lockdown and restriction of movement during the exponential rise in daily cases, there was a significant net migration of households from NYC boroughs to the neighboring counties in NJ, CT and NY State. We propose that the second peak in daily cases in these counties around NYC was due, in part, to the movement of people from NYC boroughs to these counties. We estimate the movement of people using âChange of Addressâ (CoA) data from the US Postal Service, provided under the âFreedom of Information Actâ of 1967. To identify the timing of the second peak and the number of cases in it, we use a previously proposed SIR model, which accurately describes the early stages of the coronavirus pandemic in European countries. Subtracting the model fits from the data identified, we establish the timing and the number of cases, NCS, in the second peak. We then related the number of cases in the second peak to the county population density, P, and the excess Change of Address, ECoA, into each county using the simple model N_CS~P^α E_CoA^ÎČ which fits the data very well with α = 0.68, ÎČ = 0.31 (R^2 = 0.74, p = 1.3e-8). We also find that the time between the first and second peaks was proportional to the distance of the county seat from NY Penn Station, suggesting that this migration of households and disease was a directed flow and not a diffusion process. Our analysis provides a simple method to use change of address data to track the spread of an infectious agent, such as SARS-Cov-2, due to migrations away from epicenters during the initial stages of a pandemic. +
++IMPORTANCE: The emergency of COVID-19 requires the implementation of urgent strategies to prevent the spread of the disease, mainly in health personnel, who are the most exposed and has the highest risk of becoming infected with the SARS-COV-2. Drug repurposing is a pragmatic strategy, a faster and cheaper option, compared to the new drug development that has proven successful for many drugs and can be a key tool in emergency situations such as the current one that requires quick action. In addition, considering the limited access to vaccines for developing countries, preventive use of ivermectin can be a palliative that minimizes the risks of infection. OBJECTIVE: To evaluate the protective effect of the combination Ivermectin / Iota- Carrageenan (IVER/IOTACRC), intensive treatment with repeated administration in oral- and nasal-spray, respectively, as a prophylaxis treatment prior to exposure to SARS-CoV-2, in health personnel at Public Healthcare Centers. PARTICIPANTS, DESIGN AND SETTING: Randomized controlled 1-1 clinical trial in Personal Health, n = 234. The subjects were divided into experimental (EG: n=117; 39.6 ± 9.4 years old, 65F) and control groups (CG: n=117; 38.4 ± 7.4 years old, 61F). The EG received Ivermectin orally 2 tablets of 6 mg = 12 mg every 7 days, and Iota-Carrageenan 6 sprays per day for 4 weeks. All participants were evaluated by physical examination COVID-19 diagnosed with negative RT-PCR at the beginning, final, and follow-up of the protocol. Differences between the variables were determined using the Chi-square test. The proportion test almost contagious subject and the contagion risk (Odds Ratio) were calculated using software STATA. The level of statistical significance was reached when p-Value < 0.05. RESULT: The number of subjects who were diagnosed with COVID-19 in EG was lower, only 4 of 117 (3.4%) than subjects in CG: 25 of 117 (21.4%) (P-Value = 1.10-5). Nineteen patients had mild symptoms, 4 were in EG whereas, 15 were in CG (p-Value = 0.001). Seven subjects were moderate, and 3 with severe diagnostics, all them in CG. The probability (Odds Ratio) of becoming ill with COVID-19 was significantly lower in EG with values of 0.13, 95% 0.03 to 0.40; p-Value = 1.10-4, this value (<1) indicates a protective effect of the IVER/IOTACRC in the EG. Logistic regression test demonstrated that treatment was effective to prevent COVID-19 (Odds Ratio 0.11, 95% 0.03 to 0.33; p-Value = 1.10-4). We also found that when increase the age, decrease contagious risk (Odds Ratio 0, 93, 95% 0.88 to 0.98, p-Value= 0, 02). On the other hand, the probability of contracting COVID-19 was dependent on the patient9s preexisting comorbidity (Odds Ratio 5.58, 95% 2.20 to 14.16, p-Value = 1.10-5). The other variables sex and designation were independent. CONCLUSION: The intensive preventive treatment (short-term) with IVER/IOTACRC was able to reduce the number of health workers infected with COVID-19. This treatment had also effect in preventing the severity of the disease, since all patients treated were mild. We propose a new therapeutic alternative for prevention and short-term intervention scheme (intensive) that is of benefit of the health worker in this pandemic accelerated time. This intervention did not produce lack of adherence to treatment or adverse effects. +
++Background: The emergence of COVID-19 requires alternative treatments based on the reuse of drugs as a strategy to prevent the progression of the disease in patients infected with SARS-COV-2. The goal was to evaluate the use of ivermectin in mild stage outpatients to heal and / or reverse the progression of COVID-19 disease towards the development of moderate or severe stages. Methods: Cluster Assigned Clinical Trial (2:1) in outpatients, n = 234. The subjects were divided into experimental (EG: n = 110) and control groups (CG: n = 62). The EG received ivermectin orally 4 drops of 6 mg = 24 mg every 7 days for 4 weeks. All participants were diagnosed by positive RT-PCR for COVID-19 and were evaluated by clinical examination, at the beginning and the end of protocol. Data analyzed were applied the proportion, bivariate, and logical regression tests with level significance p < 0.05. This study was registered at ClinicalTrials.gov Identifier NCT04784481. Findings: Both groups were similar in age, sex, and comorbidities (EG: 56F, median age= 40.0, range: 18.0 - 75.0; CG: 34F, median age = 37.5, range: 18.0 - 71.0). A significant reduction in the symptom numbers was observed in the EG when the medical examination was performed from 5th to 9th days, after starting treatment (p = 0.0026). Although, medical examination from 10th to 14th day, showed a progressive reduction of the percentage symptom numbers, these were not significative in both groups. A higher proportion of medical release was observed in EG (98.2%) vs CG (87.1%) (p = 0.003). EG showed 8 times more chance of receiving medical release than CG (OR 7.99, 95% CI: 1.64 -38.97, p = 0.003). The treatment effect with ivermectin to obtain medical release was analyzed by the logistic regression model based in the following control variables: sex, age, and comorbidities. Then, the chance to obtain medical release was maintained in EG (OR 10.37, 95% CI: 2.05 - 52.04, p = 0.005). Interpretation: Treatment with ivermectin in outpatients with mild stage COVID-19 disease managed to slightly reduce the symptom numbers. Also, this treatment improved the clinical state to obtain medical release, even in the presence of comorbidities. The treatment with ivermectin could significantly prevent the evolution to serious stages since the EG did not present any patient with referral to critical hospitalization. +
++Previous COVID-19 prognostic models have been developed in hospital settings, and are not applicable to COVID-19 cases in the general population. There is an urgent need for prognostic scores aimed to identify patients at high risk of complications at the time of COVID-19 diagnosis. The RDT COVID-19 Observational Study (RCOS) collected clinical data from patients with COVID-19 admitted regardless of the severity of their symptoms in a general hospital in India. We aimed to develop and validate a simple bedside prognostic score to predict the risk of hypoxaemia or death. 4035 patients were included in the development cohort and 2046 in the validation cohort. The primary outcome occurred in 961 (23.8%) and 548 (26.8%) patients in the development and validation cohorts, respectively. The final model included 12 variables: age, systolic blood pressure, heart rate, respiratory rate, aspartate transaminase, lactate dehydrogenase, urea, C-reactive protein, sodium, lymphocyte count, neutrophil count and neutrophil/lymphocyte ratio. In the validation cohort, the area under the receiver operating characteristic curve (AUROCC) was 0.907 (95% CI, 0.892-0.922) and the Brier Score was 0.098. The decision curve analysis showed good clinical utility in hypothetical scenarios where admission of patients was decided according to the prognostic index. When the prognostic index was used to predict mortality in the validation cohort, the AUROCC was 0.947 (95% CI, 0.925-0.97) and the Brier score was 0.0188. If our results are validated in other settings, the RCOS prognostic index could help improve the decision making in the current COVID-19 pandemic, especially in resource limited-settings. +
++Background and objective. Long-term pulmonary sequelae following SARS-CoV-2 pneumonia are not yet confirmed, however preliminary observations suggests a possible relevant clinical, functional and radiological impairment. The aim of this study was to identify and characterise pulmonary sequelae caused by SARS-CoV-2 pneumonia at 6-month follow-up. Methods. In this multicenter, prospective, observational cohort study, patients hospitalised for SARS-CoV-2 pneumonia and without prior diagnosis of structural lung diseases were stratified by maximum ventilatory support (oxygen only, continuous positive airway pressure (CPAP) and invasive mechanical ventilation (IMV)) and followed up at 6 months from discharge. Pulmonary function tests and diffusion capacity for carbon monoxide (DLCO), 6 minutes walking test, chest X-ray, physical exam and modified Medical Research Council (mMRC) dyspnoea score were collected. Results. Between March and June 2020, 312 patients were enrolled (83, 27% women; median [IQR] age 61.1 [53.4,69.3] years). The parameters that showed the highest rate of impairment were DLCO and chest-X-ray, in 46% and 25% of patients, respectively. However, only a minority of patients reported dyspnoea (31%), defined as mMRC â„ 1, or showed a restrictive ventilatory defects (9%). In the logistic regression model, having asthma as comorbidity was associated with DLCO impairment at follow-up, while prophylactic heparin administration during hospitalisation appeared as a protective factor. Need for invasive ventilatory support during hospitalisation was associated with chest imaging abnormalities. Conclusion. DLCO and radiological assessment appear to be the most sensitive tools to monitor patients with COVID-19 during follow-up. Future studies with longer follow-up are warranted to better understand pulmonary sequelae. +
+Study to Evaluate the Viral Load Reduction of a Single Dose of Plitidepsin in Adult Patients With COVID-19 - Condition: Â COVID-19
Interventions:  Drug: Plitidepsin;  Drug: Symptomatic Treatment
Sponsors:  PharmaMar;  Apices Soluciones S.L.
Not yet recruiting
ANTIcoagulation in Severe COVID-19 Patients - Condition:  Severe COVID-19 Pneumonia
Interventions:  Drug: Tinzaparin, Low dose prophylactic anticoagulation;  Drug: Tinzaparin, High dose prophylactic anticoagulation;  Drug: Tinzaparin,Therapeutic anticoagulation
Sponsor:  Assistance Publique - HÎpitaux de Paris
Not yet recruiting
Immunogenicity and Safety of Recombinant COVID-19 Vaccine (CHO Cells) - Condition: Â COVID-19
Interventions: Â Biological: a middle-dose recombinant COVID-19 vaccine (CHO Cell) (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose recombinant COVID-19 vaccine (CHO Cell) (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a middle-dose recombinant COVID-19 vaccine (CHO Cell) (60-85 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose recombinant COVID-19 vaccine (CHO Cell) (60-85 years) at the schedule of day 0, 28, 56; Â Biological: a middle-dose placebo (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose placebo (18-59 years) at the schedule of day 0, 28, 56; Â Biological: a middle-dose placebo (60-85 years) at the schedule of day 0, 28, 56; Â Biological: a high-dose placebo (60-85 years) at the schedule of day 0, 28, 56
Sponsors:  Jiangsu Province Centers for Disease Control and Prevention;  Academy of Military Medical SciencesïŒAcademy of Military SciencesïŒPLA ZHONGYIANKE Biotech Co, Ltd. LIAONINGMAOKANGYUAN Biotech Co, Ltd
Recruiting
Neuromodulation in COVID-19 Patients - Condition: Â COVID-19
Interventions:  Device: Transcranial direct-current stimulation;  Device: Sham Transcranial direct-current stimulation
Sponsors:  DâOr Institute for Research and Education;  Rio de Janeiro State Research Supporting Foundation (FAPERJ);  Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico;  Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior.
Not yet recruiting
Clinical Decision Support System Based on Non-invasive Tele-monitoring of COVID-19 Patients - Condition: Â COVID-19
Intervention: Â Device: Clinical decision support system based on non-invasive multimodal monitoring
Sponsors:  Increase-Tech;  Hospital ClĂnico Universitario de Valladolid;  University of Valladolid;  Sanidad de Castilla y LeĂłn
Active, not recruiting
Evaluation of ADG20 for the Treatment of Mild or Moderate COVID-19 - Condition: Â COVID-19
Interventions:  Drug: ADG20;  Drug: Normal saline
Sponsor:  Adagio Therapeutics, Inc.
Recruiting
A Study to Test BI 767551 in People With Mild to Moderate Symptoms of COVID-19 - Condition: Â COVID-19
Interventions:  Drug: BI 767551 intravenous;  Drug: BI 767551 inhaled;  Drug: Placebo intravenous;  Drug: Placebo inhaled
Sponsor:  Boehringer Ingelheim
Not yet recruiting
Tele-rehabilitation Program After Hospitalization for COVID-19 - Condition: Â COVID-19Â Pneumonia
Interventions: Â Other:Â TR; Â Other:Â TSu
Sponsors:  Istituti Clinici Scientifici Maugeri SpA;  Istituto Auxologico Italiano
Recruiting
Pilot Trial of XFBD, a TCM, in Persons With COVID-19 - Condition: Â Covid19
Interventions:  Drug: Xuanfei Baidu Granules;  Other: Placebo
Sponsor:  Darcy Spicer
Recruiting
SERUR: COVID-19 Serological Survey of Staff From the University Reims-Champagne Ardennes - Condition: Â Covid19
Intervention:  Diagnostic Test: Anti-SARS-CoV2 Serology
Sponsor:  Université de Reims Champagne-Ardenne
Completed
Study to Evaluate the Safety, Tolerability, and Immunogenicity of a Lyophilized Formulation of BNT162b2 Against COVID-19 in Healthy Adults - Conditions: Â SARS-CoV-2Â Infection; Â COVID-19
Intervention: Â Biological:Â BNT162b2
Sponsors:  BioNTech SE;  Pfizer
Not yet recruiting
Safety and Tolerability of Emricasan in Symptomatic Outpatients Diagnosed With Mild-COVID-19 - Condition: Â Covid19
Interventions: Â Drug:Â Emricasan; Â Other:Â Placebo
Sponsor: Â Histogen
Recruiting
Efficacy of Reinforcing Standard Therapy in COVID-19 Patients With Repeated Transfusion of Convalescent Plasma - Condition: Â Covid19
Interventions:  Other: Convalescent Plasma with antibody against SARS-CoV-2.;  Other: Standard treatment for COVID-19
Sponsors:  Hospital Son Llatzer;  FundaciĂł dâinvestigaciĂł SanitĂ ria de les Illes Balears
Recruiting
Assessment of the Impact of Oral Intervention With Cetylpyridinium Chloride to Decrease SARS-CoV-2 Viral Load in Patients With COVID-19 - Conditions: Â COVID-19; Â SARS-CoV-2Â Infection
Interventions: Â Other: ORAL INTERVENTION WITH CETYLPYRIDINIUM CHLORIDE; Â Other:Â PLACEBO
Sponsors:  Rosa Tarrago;  Dentaid SL
Recruiting
Study to Evaluate the Safety, Tolerability, and Immunogenicity of an RNA Vaccine Candidate Against COVID-19 in Healthy Children <12 Years of Age - Condition:  SARS-CoV-2 Infection, COVID-19
Interventions: Â Biological:Â Biological/Vaccine:Â BNT162b2Â 10mcg; Â Biological:Â BNT162b2Â 20mcg; Â Biological:Â BNT162b2Â 30mcg
Sponsors:  BioNTech SE;  Pfizer
Not yet recruiting
Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged virus that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2 spike protein, like SARS-CoV-1, uses the angiotensin converting enzyme 2 (ACE2) as a cellular receptor to initiate infection. Compounds that interfere with the SARS-CoV-2 spike protein receptor binding domain protein (RBD)-ACE2 receptor interaction may function as entry inhibitors. Here, we used a dual strategy of molecular docking andâŠ
Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with increased disease severity and poor clinical outcomes in diabetic patients compared with their nondiabetic counterparts. Diabetes/hyperglycemia-triggered endothelial dysfunction and hyperactive inflammatory and immune responses are correlated to twofold to threefold higher intensive care hospitalizations and more than twice the mortality among diabetic coronavirus disease 2019 (COVID-19) patients. WhileâŠ
Design and synthesis of novel phe-phe hydroxyethylene derivatives as potential coronavirus main protease inhibitors - In response to the current pandemic caused by the novel SARS-CoV-2, we design new compounds based on Lopinavir structure as an FDA-approved antiviral agent which is currently under more evaluation in clinical trials for COVID-19 patients. This is the first example of the preparation of Lopinavir isosteres from the main core of Lopinavir conducted to various heterocyclic fragments. It is proposed that main protease inhibitors play an important role in the cycle life of coronavirus. Thus, theâŠ
Role of Tissue Factor in the Pathogenesis of COVID-19 and the Possible Ways to Inhibit It - COVID-19 (Coronavirus Disease 2019) is a highly contagious infection and associated with high mortality rates, primarily in elderly; patients with heart failure; high blood pressure; diabetes mellitus; and those who are smokers. These conditions are associated to increase in the level of the pulmonary epithelium expression of angiotensin-converting enzyme 2 (ACE-2), which is a recognized receptor of the S protein of the causative agent SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronavirusâŠ
Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication - SARS-CoV-2 has currently precipitated the COVID-19 global health crisis. We developed a medium-throughput drug-screening system and identified a small-molecule library of 34 of 430 protein kinase inhibitors that were capable of inhibiting the SARS-CoV-2 cytopathic effect in human epithelial cells. These drug inhibitors are in various stages of clinical trials. We detected key proteins involved in cellular signaling pathways mTOR-PI3K-AKT, ABL-BCR/MAPK, and DNA-damage response that are criticalâŠ
A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples - COVID -19 is an acute infectious disease caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Human surfactant protein D (SP-D) is known to interact with spike protein of SARS-CoV, but its immune-surveillance against SARS-CoV-2 is not known. The study aimed to examine the potential of a recombinant fragment of human SP-D (rfhSP-D) as an inhibitor of replication and infection of SARS-CoV-2. The interaction of rfhSP-D with spike protein of SARS-CoV-2 and hACE-2 receptor wasâŠ
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening - During almost all 2020, coronavirus disease 2019 (COVID-19) pandemic has constituted the major risk for the worldwide health and economy, propelling unprecedented efforts to discover drugs for its prevention and cure. At the end of the year, these efforts have culminated with the approval of vaccines by the American Food and Drug Administration (FDA) and the European Medicines Agency (EMA) giving new hope for the future. On the other hand, clinical data underscore the urgent need for effectiveâŠ
Inhibition of Human Coronaviruses by Antimalarial Peroxides - As the toll of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic continues, efforts are ongoing to identify new agents and repurpose safe drugs for its treatment. Antimalarial peroxides have reported antiviral and anticancer activities. Here, we evaluated the in vitro activities of artesunate (AS) and two ozonides (OZ418 and OZ277) against human α-coronavirus NL63 and ÎČ-coronaviruses OC43 and SARS-CoV-2 in several cell lines. OZ418 had the best selectivity index (SI) inâŠ
Interleukin-1 and interleukin-6 inhibition in patients with COVID-19 and hyperinflammation - No abstract
Interleukin-1 and interleukin-6 inhibition in patients with COVID-19 and hyperinflammation - Authorsâ reply - No abstract
Perspectives on plant flavonoid quercetin-based drugs for novel SARS-CoV-2 - CONCLUSION: The antiviral properties of flavonoid and the molecular mechanisms involved are reviewed. Further, proof for this concept is given by docking of key proteins from SARS-CoV-2 with quercetin.
BRD4 targeting nanotherapy prevents lipopolysaccharide induced acute respiratory distress syndrome - Acute respiratory distress syndrome (ARDS) is a life threatening respiratory disease associated with pulmonary edema, alveolar dysfunction, hypoxia, and inflammatory cell accumulation. The most contagious form of COVID-19 associated with ARDS caused by SARS-CoV-2. SARS-CoV-2 majorly produces the cytokine storm and severe lung inflammation and ultimately leads to respiratory failure. ARDS is a complex disease and there is no proper therapeutics for effective therapy. Still, there is a huge scopeâŠ
Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients - The severe forms and worsened outcomes of COVID-19 (coronavirus disease 19) are closely associated with hypertension and cardiovascular disease. Endothelial cells express Angiotensin-Converting Enzyme 2 (ACE2), which is the entrance door for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The hallmarks of severe illness caused by SARS-CoV-2 infection are increased levels of IL-6, C-reactive protein, D-dimer, ferritin, neutrophilia and lymphopenia, pulmonary intravascularâŠ
Proteomic Analysis Identifies the RNA Helicase DDX3X as a Host Target Against SARS-CoV-2 Infection - COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome in infected cells may represent a powerful tool to identify cellular proteins hijacked by viruses for their life cycle and develop host-oriented antiviral therapeutics. Here we report the proteomic characterization of host proteins interacting with SARS-CoV-2 Nucleoprotein in infected Vero E6 cells. We identified 24âŠ
Fever: Could A Cardinal Sign of COVID-19 Infection Reduce Mortality? - With mortality rising from the COVID-19 pandemic, we may be overlooking a key aspect of the immunological response. Fever is a cardinal sign of this rampant infection; however, little attention has been paid towards how a fever may work in our favor in overcoming this disease. Three key aspects of patient care - fever, fluid, and food - can be harmonized to overcome COVID-19 infection. Both animal and human studies have demonstrated that fever suppression during viral infections, either throughâŠ
5-(4-TERT-BUTOXY PHENYL)-3-(4N-OCTYLOXYPHENYL)-4,5-DIHYDROISOXAZOLE MOLECULE (C-I): A PROMISING DRUG FOR SARS-COV-2 (TARGET I) AND BLOOD CANCER (TARGET II) - The present invention relates to a method ofmolecular docking of crystalline compound (C-I) with SARS-COV 2 proteins and its repurposing with proteins of blood cancer, comprising the steps of ; employing an algorithmto carry molecular docking calculations of the crystalized compound (C-I); studying the compound computationally to understand the effect of binding groups with the atoms of the amino acids on at least four target proteins of SARS-COV 2; downloading the structure of the proteins; removing water molecules, co enzymes and inhibitors attached to the enzymes; drawing the structure using Chem Sketch software; converting the mol file into a PDB file; using crystalized compound (C-I) for comparative and drug repurposing with two other mutated proteins; docking compound into the groove of the proteins; saving format of docked molecules retrieved; and filtering and docking the best docked results. - link
USING CLINICAL ONTOLOGIES TO BUILD KNOWLEDGE BASED CLINICAL DECISION SUPPORT SYSTEM FOR NOVEL CORONAVIRUS (COVID-19) WITH THE ADOPTION OF TELECONFERENCING FOR THE PRIMARY HEALTH CENTRES/SATELLITE CLINICS OF ROYAL OMAN POLICE IN SULTANATE OF OMAN - - link
Peptides and their use in diagnosis of SARS-CoV-2 infection - - link
A PROCESS FOR SUCCESSFUL MANAGEMENT OF COVID 19 POSITIVE PATIENTS - - link
IN SILICO SCREENING OF ANTIMYCOBACTERIAL NATURAL COMPOUNDS WITH THE POTENTIAL TO DIRECTLY INHIBIT SARS COV 2 - IN SILICO SCREENING OF ANTIMYCOBACTERIAL NATURAL COMPOUNDS WITH THE POTENTIAL TO DIRECTLY INHIBIT SARS COV 2Insilico screening of antimycobacterial natural compounds with the potential to directly inhibit SARS COV2 relates to the composition for treating SARS-COV-2 comprising the composition is about 0.1 â 99% and other pharmaceutically acceptable excipients. The composition also treats treating SARS, Ebola, Hepatitis-B and HepatitisâC comprising the composition is about 0.1 â 99% and other pharmaceutically acceptable excipients. - link
Sars-CoV-2 vaccine antigens - - link
SARS-COV-2 BINDING PROTEINS - - link
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Ein BildschirmgerÀt mit verbesserter Wirkung bei der Befestigung von UV-Entkeimungslampen, umfassend: ein BildschirmgerÀt, das einen Umfang hat; eine UV-Entkeimungslampe, die sich am Umfang des BildschirmgerÀts befindet; eine Stromquelle, die elektrisch mit der UV-Entkeimungslampe verbunden ist; eine Steuerschaltung, die elektrisch mit der UV-Entkeimungslampe verbunden ist; und eine Befestigungsvorrichtung, durch die die UV-Entkeimungslampe am Umfang des BildschirmgerÀts befestigbar ist, wobei die Befestigungsvorrichtung einen Sitzkörper, eine erste Klemmplatte und eine zweite Klemmplatte aufweist, wobei der Sitzkörper mit der UV-Entkeimungslampe versehen ist, wobei die erste Klemmplatte und die zweite Klemmplatte beabstandet am Sitzkörper gleitbar angeordnet sind, wodurch ein Klemmabstand zwischen der ersten Klemmplatte und der zweiten Klemmplatte besteht, wobei ein elastisches Element zwischen der zweiten Klemmplatte und dem Sitzkörper angeordnet ist, um die zweite Klemmplatte dazu zu zwingen, sich der ersten Klemmplatte zu nÀhern.
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Schublade mit antiepidemischer Wirkung, mit einem Schrank (1); mindestens einer Schublade (2), die in dem Schrank (1) angeordnet ist, wobei jede Schublade (2) einen Schubladenraum (25) aufweist; einer UV-Sterilisationsvorrichtung (3), die an der Schublade (2) angeordnet ist; einer Stromquelle (4), die elektrisch mit der UV-Sterilisationsvorrichtung (3) verbunden ist; einer Steuerschaltung (5), die elektrisch mit der Stromquelle (4) und der UV-Sterilisationsvorrichtung (3) verbunden ist; und einem Sensor (6), der elektrisch mit der Steuerschaltung (5) verbunden ist.
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LĂŒftungssystem fĂŒr einen mit öffnbaren Fenstern (16) ausgestatteten GebĂ€uderaum, gekennzeichnet dadurch, dass es ein GehĂ€use (18) und einen Ventilator (20) aufweist, wobei durch das GehĂ€use eine vom Ventilator erzeugte Luftströmung strömen kann, wobei das GehĂ€use dafĂŒr eine Einströmöffnung (24) fĂŒr Luft und eine Ausströmöffnung (22) fĂŒr Luft enthĂ€lt, wobei eine der beiden Ăffnungen der Form eines Ăffnungsspalts (26) zwischen einem FensterflĂŒgel (12) und einem Blendrahmen (14) des Fensters (16) angepasst ist.
Inside the Koch-Backed Effort to Block the Largest Election-Reform Bill in Half a Century - On a leaked conference call, leaders of dark-money groups and an aide to Mitch McConnell expressed frustration with the popularity of the legislationâeven among Republican voters. - link
Biden and the Blame Game at the Border - The issues involved are nearly impossible to settle as long as policymakers regard decency as a political weakness rather than as a moral strength. - link
The Politics of Stopping Pandemics - Even before the COVID-19 crisis, global instability had caused a worrying rise in epidemics. Medical science alone wonât be able to turn the tide. - link
In the Clubhouse - The audio-only social network is like a conference in your headphones. Could it become something more? - link
Recovering from the Emotional Challenges of the Pandemic - A psychologist considers the possible effects of a global experience of long-term stress. - link
+Theyâre teens. Theyâre bounty hunters. Theyâre Teenage Bounty Hunters! +
++Is there something about a teen TV show with a ridiculous name? Maybe itâs the outsized weight of Buffy the Vampire Slayer skewing my perceptions, but it seems as though the campier and sillier a teen showâs title is, the better the show is likely to be. +
++Teenage Bounty Hunters, a one-season wonder executive-produced by Jenji Kohan (Orange Is the New Black, Weeds) that premiered on Netflix last summer, is certainly no exception to that theoretical rule. The show is a frothy delight, a sweet-natured and whip-smart coming of age story about two fraternal twins living in Atlanta, Georgia, who find themselves moonlighting as bounty hunters in training. +
++The results are incredibly fun â and they include some pretty sophisticated discussion of heady themes like religion, race, class, and queerness. All that combined with a slyly stylish ear for dialogue that can pull off lines like, âA horse on the force is a cop.â âOf course,â and youâve got a nigh unstoppable charm offensive. Netflix canceled the show after its first and only season despite solid reviews, but you can still inhale all 10 hour-long episodes in a deeply enjoyable weekend binge. +
++At the center of Teenage Bounty Hunters are Blair (Anjelica Bette Fellini) and Sterling (Maddie Phillips), the twins who find themselves juggling their schoolwork with bounty hunting. Their sisterly bond anchors the show: Theyâre prone to periodic bickering, but they are exuberant in their mutual love for one another. In a witty touch, they periodically communicate in twin telepathy, the rest of the world going fuzzy around them as the camera zooms into extreme closeups of their faces and they have extended conversations with their eyes. +
++Both twins consider Blair to be the bad twin and Sterling the good one, which is a matter of aesthetics as much as anything else. Blair is brunette, a metalhead, and into smoky eyeliner, while Sterling is blonde, fond of argyle, and a leader in the sistersâ shared Bible studies class. Obviously Blairâs the bad one. +
++But Teenage Bounty Hunters tips its hand that it will be complicating that dynamic when in Sterlingâs very first scene, she talks her boyfriend into having sex by quoting scripture to him. And when she confesses sheâs lost her virginity, Blair is both scandalized that Sterling has reached this milestone before her â âYou mean sex like Iâm always talking about?â â and sweetly supportive. âI am so proud of her,â she tells their unimpressed boss after filling him in on the details. +
++The boss in question is Bowser (Kadeem Hardison), a bounty hunter who finds himself taken, in spite of himself, with the twinsâ skip-catching abilities. Field hockey star Blair is a fast runner, and daddyâs girl Sterling is an uncanny shot with a gun. Moreover, the upper-class evangelical white twins have access to parts of the Atlanta social scene that Bowser, as a Black man, canât otherwise get to. +
++So Bowser gives in to Blair and Sterlingâs pleas to take them on as his apprentices. He tells their parents that theyâre working at the frozen yogurt shop he manages, and he tells the bail bondswoman who feeds him cases that theyâre college students. (That last oneâs a pretty tricky sell after Blair and Sterling dissolve into teenaged giggles upon seeing the word âpenetrateâ in one of Bowserâs files.) And in exchange, Blair and Sterling earn enough cash to pay for the damages they caused to their fatherâs pickup truck after they crashed it. The team becomes a perfect Odd Trio: Forever grumbling and jaded ex-cop Bowser unites with bubbly private school girls Blair and Sterling, and together, they fight crime. +
++Their cases lead them into tricky social critiques of the police, the Southâs confederate legacy, the criminalization of sex workers, and gun laws. But as they pursue their glamorous new careers in bounty hunting, Blair and Sterling also have to chase the toughest skip of all: adulthood. (Work with me here.) +
++Their snooty Christian private schoolâs resident mean girl spreads a rumor that Sterling is having sex. And while Sterling maintains that she doesnât regret any of her choices and can quote the Bible verses to support them, she still has to navigate the ensuing social fallout. Plus, everything gets a lot more complicated when Sterling starts to realize she might actually have feelings for the mean girl. +
++Meanwhile, Blair is struggling to navigate balancing her first real relationship with the time demands of clandestine bounty hunting. Adding to the complications is the fact that her boyfriend, Miles, is Black, and Blairâs family is both extremely white and extremely conservative. âItâs an honor to be Black for your daughter,â Miles tells Blairâs mother after she makes an awkward speech about how glad she is that he can introduce Blair to a different way of life. +
++Itâs in Teenage Bounty Huntersâ simultaneously affectionate and clear-eyed portrait of white Southern evangelicalism that the show does its most original work. Blair and Sterling are surrounded by hypocritical adults who mouth religious platitudes while glorying in outright racism and misogyny: One early villain is a local church leader who hires and then beats a sex worker. But the twins are also surrounded by well-meaning adults who are genuinely trying to live up to the tenets of their faith, with varying degrees of success, and in their various failures, they spotlight the failures of the systems in which they are living. And as the girls try to confront their growing disillusionment with the grownups all around them, they do so while maintaining a sincere religious faith to which the show never condescends. +
++Now, would the whole thing have been even better if series creator Kathleen Jordan had stuck by her original title of Slutty Teenage Bounty Hunters? Alas, we may never know. But what we did get is pretty fantastic in its own right. +
++Teenage Bounty Hunters is streaming on Netflix. For more recommendations from the world of culture, check out the One Good Thing archives. +
+Bidenâs new plan takes an expansive view of infrastructure. +
++President Joe Biden proposed his opening bid on Wednesday for a $2 trillion infrastructure package that pushes the US towards a clean energy economy. +
++The bulk of Bidenâs plan deals with upgrading Americaâs roads, bridges, and public transit, but it also takes an expansive definition of the word âinfrastructure,â expanding long-term care for the elderly through Medicaid, banning exclusionary zoning, and investing in community-based violence reduction programs, among many other things. +
++âThe American Jobs Plan,â which he will formally introduce later today in Pittsburgh, Pennsylvania, will invest about $2 trillion over the next eight years, amounting to about 1 percent of Americaâs gross domestic product (GDP) per year over that time, an administration official estimated. +
++The plan includes $621 billion in infrastructure spending dedicated to rebuilding the nationâs roads, bridges, ports, and rail systems. It also contains $300 billion to bolster manufacturing, $213 billion for affordable housing, and a collective $380 billion for research and development, modernizing Americaâs electricity grid, and installing high-speed broadband around the country. The plan also contains $400 billion for home and community-based health and elder care. +
++The White House estimates the infrastructure plan will be paid for within the next 15 years, if Bidenâs newly proposed âMade in Americaâ tax plan is also passed. That tax plan would raise the corporate tax rate to 28 percent to pay for infrastructure, and close a number of loopholes to prevent corporations from stashing their money in offshore banks to evade taxes. It does not, however, raise the capital gains tax â an idea Biden initially floated during his presidential campaign. +
++Biden plans to argue that revitalizing American infrastructure will create millions of good-paying jobs, lower the countryâs carbon emissions, and help the US compete on the world stage â especially with China. +
++âPart of the economic logic of this plan is that this is not just about infrastructure, but itâs about creating more jobs and more industrial strength in the United States,â a Biden administration official told reporters. âWhen you make these infrastructure investments and couple it with the presidentâs commitment to buy American, youâre pulling forward and creating demand that will help accelerate new industries in the US.â +
++Bidenâs infrastructure package will be paired with a second piece of his jobs plan, focused on paid family and medical leave and expanded health insurance, that heâs expected to unveil in the coming weeks. +
++This wide-ranging list of priorities â with another package yet to come â shows just how much Biden and Congressional Democrats are hoping to pass in a relatively short amount of time. With the 2022 midterms on the horizon, Democrats are running against the clock with already razor-thin majorities in the House and Senate. And unless Democrats can convince the Senate parliamentarian otherwise, they have just one more chance to pass a bunch of priorities through budget reconciliation â which requires just 51 votes, rather than the filibuster-proof 60. +
++Bidenâs jobs plan also shows an administration that is fundamentally re-thinking the role of government in America. Rather than the anti-government ethos that has permeated both Democratic and Republican administrations since Ronald Reagan, the Biden administration is embracing the big government mantle of historic Democratic presidents Franklin Delano Roosevelt and Lydon B. Johnson. +
++Multiple sources told Vox that while the White House plans to make bipartisan overtures to Congressional Republicans, they ultimately view budget reconciliation as a reliable fallback plan to get an ambitious package passed. +
++âI think that is the end game of all of this, most of this will be done through a reconciliation package,â a Democratic congressional aide told Vox. âThatâs what the White House believes at the end of the day.â +
++Even so, the process will likely drag on much longer than the passage of Bidenâs earlier $1.9 trillion Covid stimulus bill. Precisely because the Covid bill was passed so quickly, there is a lot of pent-up demand from lawmakers to get their state and districtâs priorities included. Many members will be jockeying for their wish-lists to be included in the next budget package. +
++Infrastructure will dominate conversations on Capitol Hill for months to come. To start, hereâs Bidenâs next big economic proposal, broken down. +
++The Biden administrationâs first priority was always to get the Covid-19 pandemic under control. Now that vaccinations are ramping up and Bidenâs $1.9 trillion Covid relief package is law, the president is turning to jobs. +
++The American Jobs Plan is designed to spur job growth in a number of sectors, including construction, clean energy, and long-term care. The plan envisions millions of housing units, school buildings, and veteransâ hospitals being built and retrofitted, lead pipes being eliminated from Americaâs water infrastructure, and 500,000 electrical vehicle charging stations being installed on the nationâs roadways. +
++Comparing the planâs investment to the creation of the American highway system in the 1950s and the space race of the 1950s and 1960s, a Biden administration official said the goal of the plan is to ârevitalize our national imagination and put millions of Americans right now in work thatâs desperately needed for the nation.â +
++Here are the toplines of whatâs in the American Jobs Plan. +
++The bill also includes some ideas that might stretch the traditional definition of infrastructure: +
++Itâs worth repeating that this wide-ranging plan is Bidenâs opening bid, not a final product. The next few months of negotiations with Congress will ultimately determine how many of these provisions will make it into a final bill, and it will take even more negotiations to get that bill passed. +
++Bidenâs infrastructure plans contains one of his key campaign promises to tackle climate change: getting the nationâs economy to be powered by 100 percent clean electricity by 2035. +
++âThis is something that is part of the presidentâs plan and that he intends to work with Congress on,â the Biden administration official said of the clean energy standard in the infrastructure plan. +
++Bidenâs administration has been bullish on the potential of wind, solar, and other forms of renewable energy to become the primary source of power in the United States. Wind and solar are becoming attractive to utility companies simply because theyâve become much cheaper forms of power than that generated by fossil fuels. Renewables already produced 20 percent of US electricity in 2020, and could be poised to generate a greater share if Bidenâs plan is passed by Congress. +
++Even with the weight of the federal government behind this goal, getting the country to 100 percent clean electricity will be easier said than done. Industry and utility representatives told Vox that getting the nation to 80 percent renewable electricity by 2035 is viewed as doable, but finishing the last 20 percent will be more challenging. +
++âItâs going to require everything we have from a policy and technology standpoint, and all of the tools we have in our toolbox,â Dr. Karen Wayland, policy adviser to electricity utility coalition group Gridwise Alliance, told Vox. +
++Congressional Democrats writ large â but especially progressives â view Bidenâs infrastructure bill as their best hope to do something meaningful on climate change. Already, the effects of a warming planet are inescapable, with frequent strong storms and historic wildfires and droughts. As Biden releases his plan, progressives are already calling for something much bigger â $10 trillion in spending over the next decade on infrastructure and climate change. +
++âWe think this is a once in a lifetime opportunity to really put forward what we know we need to tackle the climate crisis that we face,â Congressional Progressive Caucus Chair and Rep. Pramila Jayapal (D-WA) told Vox in a recent interview. +
++Progressives have been in constant communication with White House staff, including White House Chief of Staff Ron Klain, communicating their desire for the administration to go even bigger. +
++âWhile this plan represents some of the boldest thinking weâve seen from the Democratic party in the last decade, the fact is itâs not bold enough to defeat the crises facing our country now,â Evan Weber, political director of youth climate organization Sunrise Movement, told Vox. âWeâre definitely communicating with the administration how weâre feeling every step of the way.â +
++With some Democratic lawmakers in the House already threatening to withhold their votes in order for a state and local tax deduction to be included in any tax policy changes to pay for infrastructure, lines are already being drawn within the Democratic caucus. +
++During Covid-19 relief bill negotiations, Biden was able to get the final product remarkably close to what he originally proposed. That could be much more difficult to replicate with an infrastructure package. +
++Whatever line the White House had to walk between pleasing moderate and progressive Democrats during the American Rescue Plan process will only be magnified in the coming months. Progressives will push the White House to be bolder, while moderates like Sen. Joe Manchin (D-WV) will push them to work with Republicans â who almost certainly would fight any attempt to raise taxes on corporations or the wealthy to pay for a massive bill. +
++âThe question there is really whatâs going to make it through the legislative process,â former Obama climate adviser John Podesta told Vox in a recent interview. +
++The process of drafting and passing an infrastructure bill and a pay-for structure that the White House, the Senate, and the House all agree on will likely be drawn out throughout the summer and into the fall. The House Transportation and Infrastructure Committee has laid out a September deadline to pass the approximately $500 billion five-year surface transportation reauthorization bill, and Senate committees are coming up with a topline number for their version of that bill. Still, negotiations over the surface transportation bill could be overshadowed by Bidenâs larger infrastructure plan. +
++While there has been some talk on Capitol Hill about passing a bipartisan roads and bridges infrastructure bill (which is seen as having the most potential for bipartisan agreement) and then putting the more ambitious pieces of Bidenâs infrastructure plan into a budget reconciliation bill, nothing is final yet. +
++âThereâs going to be a lot of members leaving their print on the next piece,â a Democratic Congressional aide told Vox. +
+Within a year, Covid-19 would take hundreds of thousands of older Americans in nursing homes. Desperate that his ailing father would not be among them, one writer bounded home. +
++
++On Wednesday morning, March 11, 2020 â just over a year ago â there were only 20 known cases of Covid-19 in Los Angeles County. +
++I hauled my 20-month-old son Desi through the airport in the same backpack we used on hikes â the easiest way to keep him from touching anything. The Delta terminal at LAX was quieter than usual but still bustling, and while the TSA agents had added rubber gloves to their ensemble, nothing seemed all that different from the last time Iâd flown earlier in the year. In line to board the plane to Detroit, I counted four people out of a hundred wearing masks. Desi stared at them with wide-eyed intrigue, not sure whether to laugh or to be afraid. +
++Itâs not like the pandemic had caught me by surprise: Iâd been following the coronavirus story since just after New Yearâs, when I saw online video clips of sick patients overwhelming a hospital in Chinaâs Hubei province. By February, the virus had surfaced in the US, and had sparked a lethal outbreak inside a nursing home in Washington state. It was easy to imagine that the virus would eventually spread across the country, but the threat still felt strangely abstract, like a brush fire on a distant ridge. +
++At the same time, I knew that my dad, who lived in a nursing home in Michigan, was in grave jeopardy. In 2018, heâd suffered a massive stroke, was given a 3 percent chance to survive the week, and had miraculously recovered well beyond every doctorâs highest expectations. Now, two years later, he remained mostly bed-bound, frozen on the right side of his body, with limited speech, but otherwise very much himself â cogent and present, able to hold up his end of a conversation through facial expressions, a jolly thumbs-up, and a few words here and there. +
++His nursing home, covered by Medicaid, provided him with a reliable baseline of care: âthree hots and a cot,â as I often joked with him â just like prison. But I knew Covid-19 was bound to eventually reach the Midwest, and that my dad, at age 83 and weakened since his stroke, was at serious risk. Catching Covid, for him, would likely be a death sentence. +
++It would be tough, I felt, to size up his safety at the nursing home and weigh all of his options from all the way across the country. And I wanted one more chance to see him, in case the worst came to pass. +
++For two years, weâd been facing the prospect of eventually losing my dad, but once heâd survived his initial stroke, the idea of his mortality had grown more distant. Now it suddenly felt vivid and close at hand, like weâd reached the final pages of a treasured book. I felt sad and frightened and helpless â so I booked a flight from LA back home to Michigan, along with my son Desmond, whom we call Desi, born the summer after my dadâs stroke. +
++Aboard the flight, I took our window seat and pulled Desi close, relieved that the middle seat was empty but unsure how I was going to manage the next several hours. Iâd been trying to keep myself from rubbing my eyes, scratching my nose, and tugging at my bottom lip â and I was struggling. +
++The idea of keeping a not-quite-2-year-old from constantly touching everything around him, then plunging his hands in his mouth, seemed far-fetched. With a few Clorox wipes, I wiped down our seats, the armrests, the window shade, the seat belt, the TV touchscreen, and the rest of the seat in front of us. Meanwhile, in the aisle seat, a man in his 60s wearing a USC Baseball jacket watched with a bemused look. âJust being extra careful,â I said, feeling sheepish. âWeâre visiting my parents, and theyâre kind of high-risk. Hey, want me to clean your screen?â +
++The guy waved me off, then donned headphones and started swiping through the TV options before popping open a bag of Doritos. +
++Five hours later, on the ride to Ann Arbor, I checked my phone and scrolled through headlines: The entire San Francisco Bay Area had shut down. Schools were closing in LA. The next one made my heart freeze: Michigan had notched its first two cases of Covid. +
++When weâd left our house that morning, we could feel a storm brewing, even if the skies were sunny and clear. +
++Now, the storm was here. +
++Hindsight has an odd way of making even the most shocking things feel predictable. In the past year, more than half a million Americans have died of Covid-19 â including people Iâve known and loved. In my circle of friends, a few have lost a parent to Covid; one unlucky soul lost both. Countless others have had to make impossible decisions to best protect their loved ones, with limited information and often from thousands of miles away. +
++Throughout, a heartless narrative has arisen from certain corners: that the lives of older and medically vulnerable people are expendable, that they can be sacrificed so that daily life for the rest of us can continue without cumbersome restriction. That they must die so the economy can survive. Itâs a line of thinking so wantonly cruel, I canât fathom how anyone could subscribe to it. But, like other global scourges â racial and religious oppression, war, famine â I suppose if you havenât personally been touched by Covidâs dark specter, thereâs a way to keep it compartmentalized. +
++I never could. The threat to my parents felt dire and desperate from the moment Covid reached our shores. And now, a year later, as the death toll continues to climb with metronomic persistence, a thousand more lives every day â I am struck that everyone who succumbs to Covid is somebodyâs mother or father, son or daughter, brother, sister, colleague, neighbor, friend, or loved one. And that the pandemicâs victims include not only those who died of disease but those friends and family members who felt the same dire desperation to keep them safe â but could not. +
++The number 500,000 is almost impossible to grasp â but, for me, the most vivid way to think of it is to picture filling every seat in Michigan Stadium, in my hometown of Ann Arbor, about five times over. Itâs the largest stadium in the country and one of the largest in the world, a place my dad and I have been going to watch college football games since I was a kid. I imagine that stadium filled to the brim on a fall Saturday, an overflowing mass of humanity, and then I imagine what it would feel like to know that every single one of those people was dead. Then I repeat that four more times. (Before long, I worry Iâll have to repeat it a fifth.) +
++Yet somehow, no matter how nightmarish the daily and cumulative tolls might be, weâve also grown used to it. What would have seemed like an implausible, dystopian vision of the future, if shown to us ahead of time, has now, in many ways, become old hat. +
++Our ability to adapt while under siege is a powerful survival mechanism. But part of what it means to adapt is to forget. This is one reason, I think, that Iâve found myself drawn again and again to the memory of those days last March â so recent and so far away â as we transitioned from our former reality into the sad, bitter, and bewildering one we soon found ourselves in. Iâm scouring those early moments: the rush of fear, the hurried trip home; and Iâm inspecting them like beach glass, reflecting on what we left behind and where weâve arrived â and how we passed from one reality to the other. +
++At my parentsâ house, my mom was delighted to see me but especially to see Desi. In turn, Desi was excited to see her but mostly excited to see her dog, a humongous black collie named Banner. As Desi teetered around the dining room, the dog hovered close, poking Desiâs face with his long snout and licking Desiâs hands and chin and the back of his neck, while Desi giggled and cried out with glee. +
++It had been three months since our last visit home, and my mom marveled at how much Desi had grown. In December, Desi had still been a baby â less independent, less aware â and now, he could walk and talk well enough to confidently say, âHi, Grandma!â My mom is deaf â she lost her hearing in 1972, through an illness, at age 29 â but sheâs a skilled lip-reader. âDid he just say, âHi, Grandma?ââ she asked me, amazed. I nodded. Smiling, Desi said it again. +
++Later, after Iâd set up Desiâs crib in my old basement bedroom, plugged in his baby monitor, mini-heater, and white noise machine, and put him to bed, I joined my mom at the dining table for a late meal. +
++âHow are you?â I asked her. +
++âIâm tired,â she said. âIâm just really tired.â Since my dadâs stroke, my mom had been single-mindedly devoted to his recovery. The first few weeks, sheâd spent her days and nights at his hospital bedside, helping him find the will and strength to live. Then, after a couple of months, once my dadâs medical condition had mostly stabilized, sheâd managed his transition out of the hospital, spending their 50th anniversary in his new room at the nursing home. +
++Medicaid covered basic room and board but none of the physical therapy and speech exercises that might help him build enough strength and independence to one day move back home. So in DIY fashion, sheâd also rallied a motley, improvised crew we called âthe Care Teamâ â nursing students and old neighborhood friends of mine who could drive his rehabilitation forward, paying them $15 an hour out of her meager earnings as a meditation teacher. +
++Against all odds, my dad was living a meaningful life again. And it was mainly due to my momâs constant, persistent, and devoted efforts â an incredible feat, all in all, for a woman who was nearly 80 herself and had her own health issues. The irony was that before my dadâs stroke, it was him whoâd been helping to take care of her, taking out the trash and recycling, going for groceries. Beyond her deafness, her vision had faded, which made it harrowing to drive more than a couple of miles, especially at night. Because of her bad knees, she used a walker to get around the house and a motorized scooter at the grocery store or the park. Diabetes and high blood pressure were growing concerns. +
++Now, just as theyâd completed the worst kind of marathon and had at last found stable ground, Covid had appeared. It was too sorrowful and exhausting to contemplate. âWe canât move him home,â she said, despairing. âI canât give him the care he needs. But to leave him at his nursing home could mean he just dies.â +
++Half an hour outside Ann Arbor, my parents owned a ragged, rustic cabin, with electricity but no running water, in the woods near a tiny inland lake. I fantasized about breaking my dad out of his nursing home, bringing him out to the cabin, and caring for him myself. Weâd play euchre, watch old movies on VHS, and listen to ballgames on the radio, until the pandemic tucked its tail between its legs and skedaddled off into the brush. +
++Of course, a fantasy is all it was: Caring for him was more than one person could manage, I had my own family to take care of, and there wouldnât even be any ballgames to listen to. +
++Still, I knew there had to be a way to keep him safe. +
++In February 2018, I was in the town of Why, Arizona, outside of Organ Pipe National Monument, on a road trip with my wife, Margaret, who was several months pregnant. One morning, I woke up to a strange jittering movement in the bed. Our baby was bopping around inside her, the first time Iâd ever been able to feel him kick. It was a thrilling, if surreal and shocking sensation. When I pressed gently back, he jabbed his feet out again: our first little game. +
++After a strange, joyful 20 minutes, Margaret grew sick of it; after all, sheâd been feeling his kicks for weeks. She climbed out of bed and I reached for my phone, only to discover a dozen texts and missed calls. Scrolling through them, I froze in alarm. During the night, my dad â my strong, healthy, buoyant dad â had collapsed in the kitchen. My mom had discovered him, hours later: eyes open, blood seeping from his nose and mouth, a bowl of ice cream melted on the counter. Now he was in the hospital in a coma. If I wanted to see him alive, I was told, I should try to get home immediately. +
++By midnight, my mom, my two brothers (in from New York and Seattle), and I had gathered around my dadâs bed in the neuro ICU at the University of Michigan hospital. We talked to him and sang him songs, though we knew he probably couldnât hear us. His brain had bled so terribly that doctorsâ hopes for recovery were close to zero. The idea that my dad would never get to meet my child â his new grandchild â was especially heartbreaking. Yet somehow, a day at a time, he stayed alive, wrapped in tubes, a ventilator pacing his breaths, until at last he came awake, regained strength, and was well enough to transfer out of the hospital to the long-term care facility where heâd been for the past two years. +
++Now, as Covid cases began to spread in the US, Iâd landed again in Michigan to see him for what I was afraid could be the last time. The plan for the week was for two members of my dadâs Care Team, a young couple named Kaitlin and Phil, to pick my dad up at his nursing home around 9 am and bring him home for a visit before taking him back that night; he often visited the house for a few hours at a time before the pandemic. +
++So when I woke up at 10:30 and the house was quiet, I knew something had gone wrong. I left Desi sleeping in his crib and slipped upstairs. In the living room, my mom sat quietly with Kaitlin and Phil. My dadâs nursing home, they told me, had jumped into lockdown mode that morning. Kaitlin, as my dadâs registered personal care assistant, had been allowed to go inside to see him, but family visitors were now prohibited. The mood in there was tense, she said, and my dad was scared. Even before Covid, he liked to watch CNN around the clock. Like me, heâd followed the coverage of the nursing homes in Seattle that had been wracked by infection, and he was clear-minded enough to understand just how much danger he might be in. +
++Our first thought, of course, was to try to bust him out of there and bring him home more permanently. But his care required more resources and expertise than we could ever manage on our own. No matter that his mind was sharp; his body had its major limitations. He needed to be changed several times a day â a two-person job. Every hour or two, he needed help shifting position to avoid bedsores. He needed an on-call nurse, 24/7, available at the touch of a button, and a doctor on site to monitor his blood pressure, blood sugar levels, and other vitals on a daily basis. Even if I were to move back into the house myself, it was way more than Iâd be able to handle on my own. +
++I felt like I was going to cry. I couldnât believe that had we arrived one single day earlier, Desi and I would have had a chance to see him, and that now our chance was gone. My mom seemed equally distraught: After nearly 52 years of marriage, would she ever see her husband again? +
++Iâve seen, in the year since, so many friends wrestle with the same kinds of regrets â punishing themselves over missed opportunities for extra time with loved ones: a family vacation never taken; a holiday visit theyâd postponed; words never spoken, until it was too late. Covid arrived with a suddenness that few could predict, and sparked outcomes few of us could have foreseen. +
++âWhat if Phil and I moved in here?â Kaitlin said slowly â not suggesting it, so much as playing out the possibilities in her head. Her sense, she told us, was that, after two years in the nursing home, my dad, physically, was entirely stable. He no longer had tubes in him to administer food or fluids. She knew what medicines the nurses gave him, and in what quantities. As for checking his vitals, it was nothing she couldnât do easily herself. +
++Over the baby monitor, I heard Desi crying. Heâd come awake in a dark basement, with no one around, and I knew he must be confused about where he was. The four of us agreed that weâd take a day to think things through. But we knew, if we were going to really try to bring my dad home from the nursing home, weâd have to quickly take decisive action. While my dadâs nursing home had let Kaitlin in that morning, there was no telling how their rules might shift on her next visit. And if Covid cases were already being confirmed in neighboring counties, it meant that undoubtedly it had already begun to spread closer to home. +
++Like every parent, parenthood changed me. While I managed, vaguely, to keep up with work, keep playing sports, keep being creative, and keep seeing friends, my old life had quickly receded. Nothing really mattered to me as much as the time I spent with my son. It was joyful and meaningful, beyond all expectations, to watch Desi evolve each day and begin to discover the world. +
++What was most unexpected, though, was all the ways my dadâs traits and habits began to sprout in me the moment Desi arrived. My whole life, Iâd mostly been annoyed and embarrassed by my dadâs constant singing, and now, bizarrely, I found myself singing all the time â relentlessly, and with unrestrained zeal. It was for Desiâs benefit, since singing seemed to soothe him, I told my wife, when she begged me to lay off. Just like my dad, Iâd make up songs about nothing and everything: hits like âDiaper Time,â âBeing and Peeing,â and âLetâs Treat Mommy Right.â +
++Over Skype, I shared the songs with my dad at his nursing home, so he could learn the words and sing along. Although it was hard for him to say the name Desi or Desmond â since the stroke, many words eluded him â we experimented one day and realized that it was easy when incorporated into a song. My dad found a tune and began to sing: Desmond, Desmond; Desmond, Desmond. I whinnied a line, in an Irish accent: âIâd sail the seven seas, to see my wee laddie,â and my dad launched back into his chorus: Desmond, Desmond. I tried another line: âMy grandson is a king; he makes me want to sing.â And my dad chimed back in: Desmond, Desmond. We made up a dozen verses, and returned to that song again and again. +
++Now my dad was all alone, a few miles away, as a killer virus closed in, and I had only a few days in town to do what I could to make sure he was out of harmâs way. +
++The morning after we arrived in Michigan, I popped Desi into the backpack and carried him down the street to a playground, while my mom cruised alongside us in her scooter, her collie Banner in tow. This was before most playgrounds had been closed off, but it was surreal to be with my mom and my toddler son at the tamest, most ordinary and innocent place imaginable â an empty grade-school playground â and feel confronted with matters of life and death. +
++âWhat do you think?â I asked my mom, as Desi explored a plastic fort. âShould we really try to bring Dad home?â +
++âI wish the house was ready,â she said. Weâd have to quickly locate and buy or rent a hospital bed. His wheelchair could only fit through the front door and the back door, and not into any of the bedrooms, so he would have to live in the living room. And since there was no way to get him into the bathroom for a shower, heâd need to be bathed in bed. +
++âAnd I wish he was more ready,â she added. +
++Slowly, incrementally, my dadâs strength had been increasing. With continued work, in six months or a year perhaps he could learn to transfer himself out of bed into his wheelchair, to dress himself, and even to use the bathroom by himself, dramatically reducing the level of care he needed. But these progressions, while in the realm of possibility, were far from likely, at least anytime soon. +
++If my mom was at all resistant, she told me, it was because after two years of mourning the life with my dad that sheâd lost, the life theyâd had for 50 years, sheâd recently found herself letting go of what was in the past and adjusting to life on her own. After a long, dark, painful period, she found herself, at last, emerging back into the light. To shake everything up overnight was frightening. +
++There was also the expense involved. Through a GoFundMe campaign and her own fundraising efforts, essentially begging friends, extended family, and the spiritual community sheâd led for decades for support, sheâd raised enough money to keep the Care Team mobilized for another year, maybe a year and a half. But if my dad came home and Kaitlin and Phil moved in to take care of him, their hourly wages, as reasonable as they were, would mount impossibly fast â not to mention the costs of the daily medications and medical supplies now covered by the nursing home through Medicaid. âWeâll burn through that money in two months,â my mom lamented. âThen what?â +
++That said, she couldnât imagine the idea of leaving my dad on his own. âItâs not coronavirus Iâm most afraid of,â she said. It was what might happen to my dad if he was left alone at the nursing home for weeks or months on end, while his nursing home was on lockdown, with no visits from the Care Team and no visits from her. âIt just breaks my heart,â she said. Banner, sensing her mood, moved close and dropped his head into her lap. +
++Back at the house, as Desi played with blocks, Banner beside him, I called a local elder care lawyer named Reid, whoâd gone to high school with my younger brother. Reid had been a godsend to us since my dadâs stroke, helping us navigate various state bureaucracies to get my dad enrolled with Medicaid and admitted into a nursing home. My first question was if weâd even legally be allowed to pull my dad out of his nursing home. +
++âHeâs not a hostage,â Reid said. The on-site doctor would have to sign off on it, but if we wanted my dad home, we could surely sort out permission. âBut you want my advice?â +
++âPlease!â +
++Reid paused: âIf it was me, Iâd leave him where heâs at.â Reid knew how limited our finances were, and how little support the state of Michigan offered to people in our circumstances as far as home care. âI just donât think your family can afford it,â he said. +
++But he offered a promising compromise. The residents at his nursing home were allowed what was called âtherapeutic leaveâ â a chance to dip out of the nursing home here and there, for a maximum of 17 days per year. If we really wanted to, Reid said, we could always try bringing my dad home for a couple of weeks, and then reassess. While our goal had always been for him to one day move home permanently, this could allow for some helpful wiggle room. +
++After hanging up, I called my dadâs nursing home directly to speak to the infection control nurse. I told her how worried I was for my dad. âI get it,â she said. âI would be, too.â But she sounded confident. For a few minutes, she detailed their infection control procedures. Nurses and aides were required to wear gloves and masks. Sheâd been having individual conversations with each staff member to help ensure they understood the gravity of the situation. And theyâd been increasing the frequency in which both the residentsâ rooms and public spaces were cleaned. +
++âIf this was your dad,â I asked, âwhat would you do?â It felt strange to pose the question in such a personal way, to ask someone, essentially, how good they were at their job, how much faith they had in their own abilities. +
++âYou know,â she said. âI really donât know. Other people have been asking me that.â Her voice grew distant, like she was talking to me from the other side of the room. I pictured her getting up to close the door to her office. At last, she went on, confidentially: âI guess if it was my dad, Iâd try and bring him home.â +
++Now that a year has passed, Covid deaths in US nursing homes have surpassed 125,000, and long-term care facilities have been called âdeath pitsâ on the front page of the New York Times. It might seem strange to remember a time when we might have considered testing fate and leaving my dad at a nursing home. But at the time I arrived in Michigan, only a handful of nursing homes had been affected. There was some hope that with the right protocols in place, a facility could remain Covid-free. +
++That view has proven to be naive. Almost universally, Covid finds a way in. Thousands of elder care facilities have dealt with Covid deaths among residents. And beyond the nursing homeâs elderly victims, hundreds of thousands of staff members have fallen ill themselves (though residents, many ill and vulnerable, have died in far greater numbers). Among my friends, several have lost their parents to Covid at facilities like my dadâs nursing home. Did they, too, agonize over whether to pull their parents out? Iâm not sure, and it seems cruel to ask now. But I know that people everywhere were â and are â wrestling with similar choices while confronted with limited and conflicting information, as well as their own unique situations. +
++By Friday morning, March 13, President Trump had declared a state of national emergency, and Kaitlin went back to visit my dad at his nursing home. She texted me a picture: two empty boxes of rubber gloves from the rack in my dadâs room. The infection control plan was already flatlining. +
++Briefly, with Kaitlinâs help, I FaceTimed with my dad. He had a chaotic look in his eyes. I tried to keep a brave face but was at a loss for what to say to him. Heâd been watching CNN, just like everyone else. +
++âDad,â I said, âI know it must be really scary right now. Weâre gonna do everything we can to help you stay safe.â I didnât want to suggest that we were going to move him home, since I still didnât know what was possible. For a couple of minutes, I dangled Desi in front of the camera, in an effort to keep the mood upbeat. Desi seemed to catch the frantic edge in my voice and to somehow understand that he was being used as a prop, which he resented; he protested by going limp in my arms. Then, without a goodbye, the connection cut out. +
++An hour later, Kaitlin and Phil came by the house. The scene at the nursing home was rough, Kaitlin said. Already, staff was missing. There was a handwritten sign taped to the front door that said NO VISITORS ALLOWED, but nobody at the entrance to enforce it. Stuck in bed, his routines disbanded, my dad appeared to already be losing it. +
++âWeâre down to try and get him home,â Kaitlin said. She and Phil had talked about it and felt it was the only thing to do. As long as they could bring their dogs along, they could decamp from the farm where they lived and move in with my parents, sleeping in the basement and giving my dad the care he needed. Theyâd keep him clean and well fed, and even continue his exercises and PT to the best extent they could, without access to a gym or a pool. +
++They couldnât stay forever, but at least a month or two, until weâd found other caretakers or another longer-term solution. And, critically, they would do it for a rate my family could afford, what amounted to a few bucks an hour. All in all, it was a moving, almost unbelievably generous offer â downright heroic. They said theyâd give my mom and me some time to discuss and left to run some errands. +
++âWhat do you think?â I asked my mom, Desi balanced in my lap. Would Kaitlin and Phil be able to manage on their own? Who would succeed them? And what if someone â even my dad â brought the virus into the house, so that not only my dadâs life was in danger but my momâs life, too? +
++My mom seemed equally nervous and excited. But after 10 minutes of discussion, she said at last, âI think we should do it. Whatâll be, will be.â She shrugged, flashed a wide smile, and gave me a fist pound. We quickly began hashing out our next steps. +
++First, weâd get the doctorâs approval to get my dad discharged, at least for a temporary âtherapeutic leave.â Hopefully, the move would be more permanent, but at least this way we could hold his room for a little while to see how things shook out. Weâd also have to quickly get a bed for him, and transform the living room to comfortably house him. +
++And weâd have to see what resources might be available from the state for additional care support, since no matter how valiant and motivated Kaitlin and Phil might be, here or there theyâd surely need a break. Talking through these logistics felt giddy and surreal. Although Iâd dreamed that one day my dad might be well enough to move back home, it had mostly seemed like a fantastical notion, like sending astronauts to Mars. But now, suddenly, it was happening. +
++When Kaitlin and Phil came back to the house, my mom and I told them it was a go. âThank you,â my mom said, hugging each of them, a bit emotional. She seemed, at the same time, to be both relieved and scared. +
++âThank you for trusting our instincts,â Kaitlin said. She suggested we make the move on Tuesday morning. That would give my mom and me three and a half days to get the house ready. +
++They drove off and I hurried to get Desi dressed in warm clothes, and loaded him, Banner, and my mom into her minivan for an afternoon field trip. Before we could go shopping for beds, we were going shopping for burial plots. +
++Forest Hill Cemetery, founded in 1857, sprawls across 65 acres on the edge of downtown Ann Arbor, tucked between the University of Michigan and the Nichols Arboretum, beside the Huron River. At its main entrance, a massive Gothic Revival stone archway greets visitors, before a maze of narrow dirt roads that split off among towering oaks and maples and grassy inclines quilted by thousands of tombstones. +
++Over the years, my parents had occasionally mentioned the idea of stopping by Forest Hill to pick out burial plots, but only in the way they might talk about planting turnips or visiting Montreal â something to do one day. +
++Even after my dadâs stroke, there were always other things that needed to be done, and I could understand how it might not be the cheeriest task. Life is littered with these kinds of rotten chores, ripe for procrastination. The tasks, the conversations, that we avoid until we canât, hoping to avoid the discomfort that comes with them. But now, with Covid coiled and ready to strike, choosing plots for my mom and my dad was finally on the front burner, and Iâd made an appointment with the Forest Hill caretaker. +
++âItâs not like weâre expecting you or dad to die anytime soon,â I assured my mom, though we both knew that was only a cloudy partial truth. My brothers and I just didnât want to have to end up making a decision for my parents that should rightfully belong to them. +
++We pulled up and my mom pushed her walker inside the old stone hut â built before the cemetery first opened â that the caretaker used as an office, while I lifted Desi from his car seat and followed her in. The floor, made of bowed, ancient wood, creaked under us, and in the deep darkness of the room, behind an enormous desk and lit in the pale yellow glow of a dying lamp, sat the caretaker, a man in his late 60s, with glasses and a voracious mustache. +
++He had the solitary vibe of a lighthouse keeper, but smiled when we came in and rose to greet us. âHi there, Iâm Larry,â he said kindly, lifting his hand. I leaped over to grasp it before my mom had a chance, like a presidential bodyguard diving in front of an assassinâs bullet. Iâd warned her not to shake anyoneâs hands but knew she still hadnât absorbed it. +
++I took a seat, immediately squeezed sanitizer into my hands, and rubbed them together in the obsessive manner Iâd recently learned from online videos. Larry gave me a peculiar look. âStrange times,â I said, not wanting to offend him. âGotta be so careful. You know. With the coronavirus and all.â +
++âI keep hearing about that,â Larry said, like Iâd mentioned a new buffet restaurant in Arborland Mall. One manâs global crisis, I could see, was another manâs idle footnote. +
++Larry passed a pair of Forest Hill pamphlets to me and my mom. He began breaking down the various costs in what I came to understand was a well-rehearsed but low-pressure sales pitch, and it occurred to me that people must comparison-shop for gravesites the same way they do for refrigerators. +
++I began translating it all into sign language for my mom, but she cut him off. It was her style to be direct, since her deafness could make communicating with strangers a challenge, and sheâd learned to minimize small talk and focus on the essentials. She spoke to him bluntly: She wanted two plots. If possible, far from the traffic on Geddes Avenue and close to the arboretum. There wasnât much more to it. +
++âOkay,â Larry said. âLetâs go take a look.â From a high shelf, he retrieved a mammoth, ragged tome, itself the size of a granite tombstone slab, then led us outside, where he climbed into his old pickup truck and asked us to follow in my momâs van. +
++For the next hour, we cruised along the cemeteryâs winding roads, while I made up silly songs for Desi to keep him mellow. Every few minutes, Larry pulled to a stop, stepped out of his truck, dragged on a cigarette, and pointed to an open patch of grass partway up the hillside where my mom and dad might one day rest in everlasting peace. âI donât think so,â my mom said to me. âToo close to the road.â Or: âThat oneâs not bad. But we can do better.â +
++Finally, at the cemeteryâs very last row, where it abutted the Arboretum, separated by a black iron fence, the truck stopped and my mom said, âThis is the place. This is gonna be it.â +
++Larry took a few steps onto the grass and pointed to a high groove in the shade of a hickory. âIâve got two plots there,â he said, âbut hereâs the thing. Theyâre not side by side. Theyâre head-to-head. Like, the long way.â +
++I explained this to my mom. âReally?â she said, and began to laugh. âI always pictured me and Dad next to each other, not with just our heads touching.â +
++âYou could have your toes touching,â I offered. +
++âOr his toes in my face,â she said, laughing harder. âSmell those stinky feet in the afterlife.â Then she sobered. âLet me get out and take a look.â I helped her out of the passenger seat, down to the muddy road, and let Desi loose from his car seat so he could roam. +
++We fell silent, and for a moment, time seemed to fold in on itself. My mom had sunglasses on, but I could see that her face had taken on a queer expression. âI wish weâd done this a long time ago,â she said. âIt wouldnât have felt so ⊠imminent.â She paused. âBut I think this is it. What do you think?â +
++âItâs a beautiful spot,â I said. âItâs really up to you.â +
++Meanwhile, Larry lit a fresh cigarette as he studied the pages of his cemetery treasure map. âHey, I found something,â he said. Fifty feet up the road, there were two plots in the same grove of trees, with the same view, but side by side. We all made our way over, and my mom took a look and nodded. We had our spot. +
++Driving back to the house, I imagined â years into the future â visiting my parentsâ graves with Desi, whoâd grown to be a teenager, as tall as me. I could see myself telling him stories about his grandparents and what theyâd been like. It was an aching feeling, to picture both of them gone. Then I wondered, would Desi do the same with his children, when I was gone? Would I be buried there, too? +
++I snapped out of it. To spend time right now mourning my parentsâ death â or even my own â would only risk squandering some of the precious moments I still hoped to have with them in the days to come. I looked over at my mom and saw that her eyes were wet. +
++âYou okay?â I asked. +
++âIâve lived a wonderful life,â she said, rubbing tears away. âBut I want to keep living. Iâm not ready to go. I want to see Desi grow up.â With that, I found that my eyes were wet, too. âAnd Jacob and Natalie,â she went on â my brother Mikeâs kids. âIf I die, listen, I want you to share some things with all of them.â +
++I stopped her. âLetâs talk about this stuff when we get home,â I said. âWhen Desi takes a nap.â +
++âAll right,â she said. +
++âYouâre not going to die,â I told her. +
++âSooner or later, I will.â +
++âLater.â +
++âOkay,â she said, tucking a wet Kleenex into her pocket and sitting up straight. âLater.â +
++By Saturday morning, Washtenaw County, where my parents live, was reporting its first Covid case. +
++The weekend passed in a rush. My brother Mike found a hospital bed for rent and arranged to have it delivered on Tuesday morning, right before my dad arrived. My mom and I recruited two people who were already members of the Care Team to come to the house in the weeks ahead as extra support â Sarah, a longtime close friend, and Donny, a high school pal. +
++Sarah lived with her boyfriend, and Donny with his girlfriend, who was Sarahâs twin sister â years before, Iâd been the one to introduce them. All four agreed to begin quarantining, working from home, and staying put other than trips to the grocery store or to my parentsâ house. That meant there would be eight people total in my parentâs âcellâ of support, including Phil and Kaitlin. A tighter circle might have been better, but I trusted everyone to be smart and stay safe in order to keep my parents free from infection, and it was way more protection than we could have offered my dad had we left him at his nursing home. +
++After dinner on Sunday night, I put Desi to bed, then spent an hour with my mom posting updates on my dadâs GoFundMe page, hoping to ignite another round of donations. In the months since weâd launched the campaign, it had been moving to see the support from friends and family, and even the most distant of acquaintances, a few of whom had been especially generous. But now our window for raising funds was narrowing. Would anyone still prioritize supporting my dad once the virus had brought hardship everywhere? +
++âI want to tell you something,â my mom said. âThis is very important.â +
++âAll right.â +
++âIf me or Dad gets sick and dies from this, I donât want you or Mike or Peter to come home for a funeral. You canât risk getting sick yourself.â She spoke pragmatically â not entirely devoid of emotion, but insulated from it. âItâs just a body,â she said. âYou can do a memorial another time, when itâs safe.â In the moment, the idea of not attending her or my dadâs funeral seemed extreme â but of course, now, her concerns have proven to be prescient. Stories abound of funerals that fueled outbreaks of their own, with dire results. And those who have taken my momâs advice have suffered, too: I have friends who still havenât been able to gather with their families to mourn loved ones who died of Covid, months ago. +
++Over the baby monitor, I heard Desi cry out in his sleep. Sometimes, heâd fuss for a minute and fall back asleep, but these cries, I knew right away, were different â a kind of urgent wailing. Still, I thought Iâd give him a few minutes to see if he could soothe himself. +
++I told my mom, âIf you were sick, of course weâd want to come home and try to help.â +
++âThey wonât let you into the hospital anyway. Please. You have to promise me.â +
++I told her that I wanted to talk it through with her, but that Desi was really upset and I had to go check on him. I hurried down to the basement and found him standing in his travel crib, his face soaked in tears. Usually, when he was crying and I picked him up, he quickly chilled out, but now he was nearly inconsolable. His whole body was shaking and wracked with sobs. +
++âWhatâs wrong, Desi?â I said, feeling helpless myself. âItâs okay, itâs okay, itâs okay.â +
++Some of the best advice Iâd gotten early on was that when a baby cries, thereâs usually a reason for it â theyâre tired, hungry, or need a diaper change. Or perhaps they might be too hot or too cold. Rarely was there another explanation. Iâd always found it helpful to have such a clear place to begin to troubleshoot. But these tears, I could tell, were different. It had been a stressful week, Desiâs daily routines were in tatters, and I imagined heâd absorbed some of the tension and heavy emotions heâd been surrounded by. +
++I pulled him into the bed with me, and he wailed against my chest. I tried singing to him, going straight to the big guns â âSwing Low, Sweet Chariot,â a song Iâd sometimes reserved as a last resort when he was an infant and got lost on a crying jag. +
++Finally, finally, Desiâs breathing slowed. I slid my phone from my pocket and sent my mom a text; she read these on her iPad, which she always kept close at hand. âHeâs OK now,â I wrote. âBut I need to stay with him. Sorry I might fall asleep.â I felt bad ditching her mid-conversation, aware it wasnât the only time Iâd shut things down when she tried to broach vital topics. But right now, Desi needed me more than my mom did. And I needed him. +
++âThatâs OK,â she wrote back. âTalk more tomorrow.â +
++âYeah tomorrow. Love you Mom.â +
++âLove you.â +
++Some people appear in your life and bring you such goodness, youâre not sure what you could have done to deserve it, but you learn, eventually, just to accept their love and kindness with a sense of mystified gratitude. Sarah is that kind of angel. +
++I met her in 2004 â a tiny, brash Native American punk rocker who grew up in a remote Chippewa community in Michiganâs Upper Peninsula â and she quickly became one of my closest friends. +
++Over the years, Sarah had grown close with my parents, too. When my dad retired, he hired her as a kind of general assistant, working one day a week, to help him with various creative projects he hoped to dig into. They became genuine pals. +
++After my dadâs stroke, Sarah rushed to the hospital â she was the first of us to arrive â and in the months that followed, she became a vital lifeline for my whole family. I stayed in Michigan for a couple of months following the stroke but eventually had to return to LA, where Margaret was getting late into her pregnancy. Crucially, Sarah continued spending time with my dad a couple of days a week â at the hospital, then at his nursing home â making it possible for me to FaceTime with him on a regular basis. +
++Now, two years after heâd collapsed in the kitchen, my dad was due to move home again, in less than 24 hours. Monday afternoon, Sarah rolled by to help me prep the house for his arrival. I popped Desi into the backpack, and he kept to himself, clutching his beloved stuffed animal, Ellie the elephant, as Sarah and I cleared out the living room and transformed it into a new room for my dad. We hauled sofas out to the garage, shifted heavy bronze sculptures my mom had welded decades earlier from one end of the room to the other, and hung drapes to give my dad a measure of privacy, since the front windows of the house looked out on the street. +
++My dad was scheduled to come home around 10 the next morning, and to catch our flight to LA, Desi and I would have to head for the airport around 5 pm. On one hand, it pained me to know that our time together would be so limited, but I wasnât sure I could extend the trip. +
++There were the small factors: When my dad came home, Kaitlin and Phil and their dogs would also be moving in, and the house would be crowded. And after a chaotic week, managing Desi all by myself, I was running out of juice. If Iâd made the trip without him, it wouldâve been a lot easier to hang in town for longer, but I was feeling burned out, and Desi seemed to also be at the end of his rope. +
++And then there were the larger factors, based on fear â rational fear â and a sense of self-preservation. I knew that the virus had been spreading, doubling its cases in three days. +
++To wait longer to fly back to LA meant increasing my chances of coming into contact with people who were infected. And Iâm in a high-risk category myself: For 15 years, Iâve been taking a drug called Humira, a powerful immunosuppressant, to combat a rare form of arthritis. From what I understood, I might not be at a substantially higher risk for contracting Covid, but if infected, my body would struggle to fight it, and my chances for a severe outcome were hugely increased. I desperately didnât want to get sick or to die, and felt eager to rejoin Margaret and cocoon myself safely at home. +
++Still, I thought of sticking around for a week or two and then renting a car and driving cross-country, back to LA, with Desi in tow. We could make it into a special kind of father-son road trip, I mused, stopping in national parks along the way, sleeping in the car or finding out-of-the-way spots to pop a tent. But Desi could barely tolerate a half-hour in his car seat. Driving 2,500 miles would be tough. Our best and safest bet was to fly back the next night, as originally planned. +
++Later, I put Desi down to sleep and began to pack up all of our stuff for the trip back to Cali; I wanted to minimize any time Iâd have to spend packing the next day, when my dad was home with us. Iâd moved most of my stuff out of the basement years before, but still there were remnants from earlier, wide-ranging chapters of my life â and every time I was home for a visit, I liked to bring a couple of random, forgotten things from the house back to LA with me: NFL pennants from my childhood, an old to-do list. +
++Far from home, the sight of these items, their weight in my hands, and even their smell, was endlessly transporting. I knew I might not be back in Michigan for many months, depending on how the pandemic shook out. (A year later, I still havenât returned.) I thought about what it would be like if my parents died and the house was sold, and how much Iâd miss it â the house Iâd grown up in, the only house our family had ever lived in. Conceivably, this might be my last night in the house as Iâd known it. What would it be like to be home again, on the far side of all of this, if my mom or my dad â or both of them â were no longer here? +
++I woke up Tuesday morning to voices upstairs, in the living room, right above me. Sarah had arrived early, by 8 am, to meet the delivery drivers from the medical supply company whoâd brought my dadâs hospital bed. Over the roar of Desiâs white-noise machine, I could hear her directing them, and the sound of the bedâs tiny wheels running over the floorboards, as the floor creaked under its intense weight. Feeling oddly jittery, I took a few deep breaths to steady myself, and squeezed out the very last dollop of adrenaline from my reserve tank, like it was an empty tube of toothpaste. Then I pulled my clothes on, careful not to wake Desi, and slipped upstairs. +
++It was a bright, gorgeous day that felt more like April or May than mid-March. For an hour, Sarah and I finished getting the house ready, sweeping and mopping, washing dishes, and ordering a few more supplies for my dad â fitted sheets for his new bed, pillows and pillowcases, gauze pads, juice, juice thickeners. Desi woke up and we fed him breakfast and got him dressed. âGrandpaâs coming home soon!â I told him. âWant to see your grandpa?â +
++âYes,â Desi nodded. He seemed to actually know who I was talking about. +
++Phil called me from in front of my dadâs nursing home. Though we hadnât told them that he was most likely moving out for good, just to keep our options open, they seemed to be assuming as much; they had rounded up my dadâs clothes, CDs, boombox, and other personal effects â cards from friends, drawings from his grandchildren â and stuffed them all in a pair of garbage bags. At 10:30, an aide wheeled him out to the parking lot, set his bags of stuff next to him, and retreated inside. +
++Twenty minutes later, Dad, Kaitlin, and Phil pulled into the driveway in Kaitlinâs Nissan Cube, with Phil driving and my dad crammed into the front passenger seat, like a circus bear in a go-kart. I lifted Desi into my arms and hurried outside to greet them, my mom and Sarah trailing just behind us. +
++âHey, Pops!â I cried, opening his door. âWelcome home, man!â I held Desi out so they were face to face. âSay, âHi, Grandpa,ââ I told Desi, forcing the action. âSay, âItâs good to see you.ââ But Desi was shy, and he turned his head away, wriggling in my grasp. My dad, meanwhile, looked frazzled, slightly confused, and rough around the edges. It was clear heâd had a tough go of it ever since his nursing home had been on lockdown. But at last he turned his head creakily to the side, took a peek at us, and flashed a wry smile, looking happy to see us, and genuinely happy to be home. +
++Once my dad was settled in his wheelchair, he looked comfortable and at ease. +
++âNice day, right?â I said. +
++âNice day,â my dad repeated, with a smile. +
++âNice day!â Desi chimed in. +
++Phil pushed my dad along the driveway, up a gentle wooden ramp, and through the front door, into the house, while I carried Desi in behind them. +
++We headed for the dining room, where my mom had laid out a spread of bagels, cream cheese, and veggies. The windows looked out over the backyard, alive with birds, and my momâs garden, which seemed to have bloomed overnight. My dad joined us at the table, Sarah made him a bagel sandwich, and my dad dug in ravenously, while Desi sat with us in his own grown-up chair, with his own bagel on a plate, slouching like a teenager. His transformation over the course of one week was astounding. Even his face looked older, rounder, more thoughtful and mature. +
++My mom, Sarah, Kaitlin, and Phil found chairs and joined us. For months after my dadâs stroke, heâd been fed through a tube, and even though heâd been eating regular meals for a year now, and making visits home every week, it was always a little surprising to see him sitting there, feeding himself, just hanging out as though heâd never left. It seemed both utterly miraculous â given all that my dad had been through and the arrival of the pandemic â and at the same time strangely normal for all of us to be gathered around the table, sharing a meal. +
++Once we were done eating, Desi climbed to the floor to play with his toys, my mom and I joined him, and Sarah rolled my dad over beside us. My dad glowed, watching Desi build stacks of blocks and knock them down, run a little wooden train along its track, and roll around with Ellie and the gaggle of stuffed animals heâd collected from around the house. +
++At one point, Desi stood and teetered over to him, hugging my dadâs leg to keep balance, like it was the trunk of a tree. I tried to imagine what it would be like, one day, for Desi to have his own child, and to be able to watch that child laugh and play and learn to walk and start to talk, the same way my dad was watching Desi â a living creature, finding its own path, that had somehow splintered off of you. +
++I picked Desi up and balanced him in my dadâs lap. âIâm your daddy, and Grandpa is my daddy,â I reminded him. âGrandpa is your daddyâs daddy.â At first, Desi wasnât too sure he wanted to be held, and looked dismayed and unsteady, as though afraid heâd get dropped. But my dad reached his left arm â his good arm â around him, and Desi relaxed in his perch. +
++âHow about âHappy Birthday?ââ I suggested. I explained that in a week, Desi would be 21 months, or one and three-quarters years old. Not the most widely celebrated of birthdays, perhaps, but Iâd noticed that Desi loved hearing âHappy Birthday,â and I liked to sing it for him whenever the 24th day of the month drew near. I also knew it was a song my dad could sing with us, without needing help with the lyrics. +
++With Desi still in my dadâs lap, all of us burst into song, and an enormous, radiant smile spread across Desiâs face. He seemed tickled by the attention and happy to be hanging with his grandpa, whoâd mostly just been the Man in the iPhone but now was here with him in real life. +
++We finished singing to him, and Desi laughed and clapped his hands together, and cried, âYay!â +
++âYay!â we cheered along with him. The room was bright with sunlight, like a Polaroid picture that had been overexposed. I felt myself glowing, surrounded by my mom, dad, and Desi, and the rest of my ad hoc family â Sarah and Kaitlin and Phil. I couldnât imagine how heartbreaking it would have been not to have had the chance to see my dad at least one more time. But if weâd come all this way and had managed only these few minutes with my dad, it wouldâve been worth it. At the same time, it crushed me to know that this could be the last of it. Why couldnât the pandemic have come a few years later, when my dad was already gone? +
++By mid-afternoon, my dad was tired. Typically, at his nursing home, he took naps for an hour or two. We wheeled him into the living room â his new bedroom â and stretched him out in a reclining chair, where he closed his eyes and was quickly asleep. Desi was ready for a nap, too. I put him in his crib in the basement with Ellie, then hurried around the house, ticking off a long list of last-minute tasks â changing a lightbulb in the attic, loading a box of my parentsâ old books â and then finished packing. +
++Sarah brought me things sheâd found over the past few months, as sheâd helped my mom pare down clutter from around the house, to send home with me to LA: old clothes, kidsâ toys, a clay sculpture Iâd made in seventh grade. Kaitlin joined in. Since she and Phil were moving into the basement, I realized, the more they could get me to pack out, the more space theyâd have for their own stuff. +
++Finally, all of our bags were packed, all of Desiâs stuff collected and stowed, and Sarah helped me lug it all out to my momâs van. In the front yard, she pointed out an abandoned waspâs nest in the branches of a maple tree. âThose are the wasps that stung me last summer!â she said. âCan you get it down?â +
++The nest, about 20 feet up, was beige, the size of a bowling ball, and looked like it was made of papier-mùché. I found a fireplace log from a stack of wood by the garage, positioned myself right underneath, and heaved it up at the nest. Right height, but a foot wide. The log crashed down and I tried again. This time, I nudged the nest ever so slightly, but it was fastened tightly to its branch and absorbed the blow without flinching. +
++My next throw was way off, the one after that far worse. But on such a beautiful spring day, with Sarahâs gleeful company, it felt just right to be flinging a log in the air, again and again, however fruitlessly, in the same yard where Iâd played as a kid, in front of the same house, surrounded by the same trees, as Sarah laughed and laughed and laughed. +
++Through the front window, I could see my dad, asleep in his chair. It was past 4 oâclock, and I knew it was irrational to spend the last hour I might ever have with him this way, pointlessly throwing a log into a tree. But that morning and early afternoon Iâd already had the golden moments with him Iâd been hoping for â and a part of me knew that whatever remaining time we spent together would only be difficult and sad. The longer I spent outside, the longer I could postpone the hardest part of my visit: having to say goodbye. +
++As he slept, my dadâs chest rose and fell with each deep breath he took. We were so lucky for him to have lived as long as he already had, I realized. A lot of my friends had lost their fathers in recent years, to cancer, heart attacks, strokes, even car accidents, at ages a decade or two younger than Dad was now. But how could anyone not feel greedy for another year with the ones they loved, then one more year, and just one more year after that? +
++Though we lived thousands of miles apart, my life was far richer with my dad around. It meant something to me to talk regularly and share stories with him of my stumbles and my successes. I especially wanted him to stick around to get to know Desi. And I wanted Desi to get to know my dad â to have his own memories of him, and not just learn about him from pictures and secondhand stories, as I had with my dadâs parents, who died before I was born. Every extra month, week, and day with my dad in the world is meaningful to me, to us. Because, despite the narrative that would soon emerge around Covid-19, the truth is, no oneâs life is disposable â no matter how old, frail, or vulnerable they might be. +
++I saw that at last my dad was awake again. All of us went out to the back porch, including Banner, for what I knew would be my last 15 or 20 minutes with my mom and my dad for the foreseeable future. +
++It was a lovely spring afternoon, but as the sun dipped lower behind the spruce trees at the edge of the yard, a cold breeze blew. Kaitlin helped my dad pull on a hoodie. I hadnât written any kind of grand speech, but I had a few ideas for how we might spend these last moments together: Among other things, I planned to present him with an Oscar. +
++My dad was a lifelong cinephile; he was the one whoâd lit in me a love for movies and had sparked my interest in filmmaking. When I was a kid, heâd hung a movie screen in our living room. Once a month he borrowed a projector from a local church and got hold of closed-captioned versions of movies like Das Boot, The African Queen, North by Northwest, and Kurosawaâs Ran. Often, before the film, my dad showed us a couple of shorts â Laurel & Hardy; The Magnificent Six-and-a-Half â the way movie houses had done when he was a kid. We made popcorn, refilling our bowls between reels. +
++The Academy Awards became a special night for us each year. For months beforehand, weâd talk about who should win and who was likely to win. And for months afterward, weâd rehash our favorite speeches, and imagine the speeches our favorite actors and filmmakers might have made, if they hadnât been robbed. No award loomed larger in Dadâs consciousness than an Oscar; it was bigger than Major League Baseballâs MVP trophy, bigger than a MacArthur âgeniusâ grant, bigger than the Nobel Prize. +
++In the weeks before my visit to Michigan, Iâd gone online and ordered a replica from an eBay store based in China and had it sent directly to my parentsâ house, in hopes it would arrive in time for me to present it to him. Serendipitously, it had shown up earlier that day. Just to be safe, Iâd cleaned the statue thoroughly with a couple of Clorox wipes. +
++On the back porch, I drew the Oscar from its case and handed it to my dad. âThis is for you, Dad,â I told him. âThank you for inspiring me.â +
++He set it on his left knee, peering at it, a little confused. A local trophy shop, I explained, had agreed to craft a nameplate for the base of the statue, once it felt safe for nonessential businesses to reopen. My dad lit up, briefly, and flashed me a smile and a thumbs-up. As Iâd hoped, he didnât seem to care that the award was fake; it signified his genuine achievements as a father. I launched into a lame and winding speech about how grateful I was that my dad had always responded to whatever interests I had as a kid by encouraging them. +
++The Oscar, I said, represented a fundamental lesson heâd instilled in me: that if something in the world excited and intrigued us, like filmmaking, we could find a way to get involved as creators, not just as fans. I reminded him of the time, at age 12, when Iâd told him Iâd wanted to make comic books, and heâd found an art class to enroll me in. +
++It wasnât an awful sentiment to share, but I could see, even as the words tumbled out of my mouth, like teeth in a bad dream, how out of place and inadequate they were, in this moment. This was a time to go bigger, deeper, not just to thank him for signing me up for a one-day class where Iâd learned to draw Marmaduke. Already, heâd lost focus on what I was saying, and was gazing with a sad look at Desi, in my lap, then out across the yard, where two squirrels battled over an acorn. +
++âDad, listen,â I told him, reaching out to clasp his left hand, the one with feeling. âYouâve been the most amazing dad. I love you so much, and I appreciate all that youâve ever done for us â Mom, me, Mike, and Peter. Weâre so lucky weâve had you in our lives, and had you as a dad.â My eyes were wet, and I could see that his eyes were moistening, too. âIâm going to try to be the kind of dad to Desi that youâve been to me. To give him all of the opportunities that youâve given me. And to show him what a wonderful world it can be.â +
++I hated that my words sounded so final, like I was afraid Iâd never see him again, even if that was exactly the case. And truthfully, it wasnât just his life I was frightened about, it was mine, too: Covid was already claiming the lives of people my age and younger. +
++I veered in a new direction. âDad,â I said, âThereâs this disease going around, and you know what, maybe you will get sick. But I know, if it happens, that youâll be all right. Youâll make it through.â I felt like a football coach giving a locker room speech, down 24 points at the half â but at the same time, I believed every word that I said. I squeezed my dadâs hand and he squeezed mine back. âI love you,â I told him. +
++He looked me in the eye and nodded. âLove you.â +
++âAnd Desi loves you.â +
++My dad smiled and eyed him. He began to sing, in a quiet voice, âDesmond, Desmond; Desmond, Desmond.â Desi watched him, eyes wide. I felt twin balloons of sadness and joy rising in my chest. +
++âWe should go,â said Kaitlin, whoâd offered to drive me to the airport. âYouâll miss your flight.â +
++âOkay,â I said, checking the time on my phone. âJust a couple more minutes.â Quickly, I snapped a few selfies of Desi, my mom, my dad, and me. Sarah took a few more of us. Then, before I said goodbye and hurried out, I asked my dad to sing one more song: âEdelweiss,â from The Sound of Music. A couple of weeks before, over FaceTime, heâd really nailed it. +
++I pulled it up on YouTube, a version with words and music, so we could all sing along. My dad started out shaky at first, but soon found his footing: +
++Edelweiss, edelweiss, every morning you greet me. +
++Small and white, clean and bright, you look happy to meet me ⊠+
++Iâd been signing the words to my mom, and after a moment she joined in: +
++Blossom of snow, may you bloom and grow, +
++Bloom and grow forever ⊠+
++Between the three of us, it might have been the most warbling, tuneless rendition of the song ever attempted, but it didnât mean we sang with any less feeling. In the film The Sound of Music, Baron von Trapp, whose native Austria has fallen under siege by the Nazis, sings âEdelweissâ as both an elegy for the country he loves and as a subtle act of defiance against an occupying force. When my dad sang the last mournful lines of the song â then, and again, now, on the back porch â I felt like he was expressing what every one of us felt, across America and around the world, praying for salvation. I lifted my voice and sang along: +
++Edelweiss, edelweiss, +
++Bless my homeland forever ⊠+
++In a week, everything had changed. The airport in Detroit was a grim, barren place, with a militarized vibe that reminded me of the weeks after 9/11. Police in midnight camo roamed with German shepherds so fierce that even Desi, doggie lover of all doggie lovers, edged away in fear. Was their presence, I wondered, meant to keep Covid at bay? +
++I wore pink rubber gloves, but it was no longer strange â many others wore gloves, too, while the TSA agents had added fierce-looking masks. Iâd dressed Desi in a Detroit Tigers jacket that Sarah had uncovered deep in my dadâs closet â a jacket that had belonged to me when I was about 6. It was still a dozen sizes too big for him, making it perfect for this trip: the ends of the sleeves dangled uselessly a foot past his hands, which meant that he couldnât touch anything. +
++We boarded the plane, and found that we were among maybe 30 passengers on the entire flight, with no one else in our row, or the rows in front of us or behind us. It may have been overkill, but after reading so much about how long the virus could live on surfaces, and knowing that Desi might very well lick the back of a seat or chew on an armrest, I cleaned the seats with Clorox wipes again, then spread an old spare sheet Iâd dug out of the basement across our entire row, and a second sheet over the row in front of us. I wasnât going to take any chances. (The irony is that neither Desi nor I had a mask; this was before the science had emerged around their efficacy.) +
++I glanced at the headlines on my phone: California had shut down all of its schools for the rest of the year. In New York City, Mayor Bill de Blasio was preparing to do the same. Four members of the Brooklyn Nets had tested positive for Covid, including Kevin Durant. And in Michigan, the number of cases had doubled since the day before, to 65. +
++Then I scrolled through the photos Iâd taken over the course of the week â my mom and Desi playing; Desi, my parents, and me, on the back porch, just a couple hours before, the sun behind us, casting a rainbow lens flare. Already, my time in Michigan seemed like a dream. I felt as tired as Iâd ever been, sleep-deprived and emotionally spent, and I stretched out across the row and closed my eyes, holding Desi as tightly to me as he was holding his furry stuffed elephant, breathing in step with him. +
++Past midnight, Michigan time, Desi and I reached LA. Margaret was there at the curb to collect us. In need of emotional release and relieved for the three of us to be reunited, I nearly cried when I saw her. It felt like weâd been gone for a year. +
++Margaret gathered Desi up in her arms and kissed his face and his head and his ears while I loaded all of our things into the trunk of her Jeep. The curbside, I noticed, was littered with hundreds of pairs of rubber gloves, tossed to the ground by passengers upon pickup, a rainbow-colored pastiche. It made sense, I supposed: No one wanted to bring dirty gloves into their loved onesâ cars. +
++For a moment I wavered, as I tugged off my own gloves and climbed behind the wheel so Margaret could ride in back with Desi, unsure which was stronger: my instinct not to risk bringing the virus into the car or my impulse never to litter. Finally, I zagged back inside the terminal to stash my used gloves in the garbage â one small, righteous deed after a week of overwhelming, confusing, and uncertain ones. Then I hopped back in the Jeep and we headed for home. +
++Five days later, my dadâs nursing home sent out a letter to every residentâs family. Since my dad hadnât officially moved out yet â he was home, technically, only on a 17-day therapeutic leave â we were still on their mailing list. The letter began: âWe want to inform you that we have received confirmation that an individual at [our nursing home] has been diagnosed with Covid-19 âŠâ +
++In the days that followed, new cases appeared. Quickly, it became clear just how lucky we were to get him home, and just how narrowly he may have escaped. A Michigan government website tallied at least 50 Covid cases at his nursing home. In the months that followed, around the country, some nursing homes would, true to the headlines, become death traps, with bodies stacked in the laundry room, in utility closets, or in sheds in the yard. A veterans home in Massachusetts clocked 76 deaths. A retirement home in South Carolina had 59. Still others have emerged largely unscathed. +
++In his first months at home, my dad thrived. Desi and I liked to FaceTime with him in the morning. Weâd sing songs and make faces at each other, and sometimes Iâd read kidsâ books to both of them, my dad chiming in here and there with a hoot or a chuckle. Sometimes Iâd run to the other room to pee or to grab Desi a snack, and Iâd leave them alone to bond with each other. When Iâd come back, Iâd try not to interrupt, but instead just watch from the doorway: the two of them communicating in their own slapdash, improvised language, a mix of simple words, grunts, squeaks, and laughter, like alien species across a vast cosmos. +
++Whatever happened, I knew it had been worth it to find a way to get my dad to safety. In the best case, weâd be home to visit him again before long, as the virus became contained. Worst case, my dad would have spent his final days in the house where heâd lived more than half his life, the house where heâd raised his family, with my mom and Banner close at his side. I knew he was taking joy, every day, in being there with them. +
++Things got harder mid-summer, when Phil and Kaitlin moved out. My brother Mike came home for a few weeks to help, but he, too, had his own family who needed him. A series of other caregivers came into our lives, some heroic, others harrowingly cavalier in their approach to Covid safety. But our options were limited to what we could afford, particularly as the pandemic stretched from weeks to months and beyond. My gravest fear, knowing how much time my mom spent at my dadâs side, was that not only would he get infected, but that she would, too. By bringing him home, and cycling caregivers through the house every day, we were putting them both at enormous risk. +
++Before Christmas, just as the first vaccine vials began to be distributed, my dadâs most capable and reliable caregiver fell sick with what seemed like Covid symptoms; his partner worked as a hospital nurse and was also sick. Only after a terrifying week did we learn that both had tested negative. +
++In January, a different caregiverâs live-in girlfriend tested positive for Covid. He had spent three days at my parentsâ house the previous week. We knew that if the caregiver was infected, my dad would likely be, too. It was painful and perverse to imagine that my parents might have evaded the disease for so long, only to get sick when they were weeks away from getting vaccinated. +
++Ultimately, the caregiver never tested positive, and neither my dad nor my mom got sick. We have been extremely lucky. Friends of mine who perfected safer protocols, who lived in parts of the country with lower infection rates â who did everything ârightâ â still lost their parents to Covid. Reasonably, they are heartsick and furious at the lack of national leadership, and at the way partisan politics eroded trust in basic science and deepened the virusâs spread. +
++I knew these friendsâ parents. Their lives were in no way expendable, and their loss is felt every hour of every day. +
++A few weeks ago, my mom wheeled my dad into Michigan Stadium, the stateâs largest vaccination site, for his first shot. The same stadium that had become a way for me to quantify the countryâs escalating death toll, as I multiplied its capacity by two, then three, then four, then five. It felt especially meaningful to me for the stadium to now signify life, hope, and renewal. My mom texted me a picture of my dad getting jabbed in the arm while flashing a thumbs-up. I was overcome, flooded with tears of relief. +
++Last week, a friend drove my mom to downtown Detroit, where she got her second shot, in the parking garage of the TCF Center, where votes were counted â and challenged â after the 2020 presidential election. In the coming months, I hope to get a shot or two myself, and then, eventually, to visit home again for the first time since the pandemic began, bringing Desi with me. Last March, a year ago, he was a baby who had just learned to walk. Now heâs a little boy who climbs mountains by my side. +
++For us, even the bleakest challenges of the past year have been redeemed by our time in nature. In the evenings, every day, an hour before sunset, Desi and I hike up Elephant Hill, a lookout point behind our house in Northeast LA. The place is a haven for Jeeps, ATVs, and motorcycles, and the dirt road that winds its way to the top is strewn with mounds of trash, but is heavenly nonetheless: towering yellow wildflowers on either side, and a dazzling three-sixty view from the summit, stretching from downtown L.A. to the snow-capped San Gabriel Mountains. Down the backside of Elephant Hill, Desi and I have our âpicnic spotâ where we hang out, wrestle, read books, eat snacks, look for birds and rabbits and butterflies, and watch the sun go down. From up here, the world looks green, fertile, both idyllic and foreboding. +
++Often, as the sun slips out of sight, and the weeds around us blow this way and that, Desi sits quietly in my lap, staring across the valley at the distant, jagged peaks. I wonder if later in life heâll remember these moments, the way I remember walking with my parents through the patch of woods behind our house when I was his age. +
++My quarantine life, like so many other peopleâs, is a strange, formless, timeless thousand-mile stroll through a desert, laced with danger, boredom, and beauty. I donât know how the pandemic will play out, if new variants or decreased vigilance will threaten the progress weâre making with vaccines; I donât know how much longer it will be until I see my parents â Desiâs grandparents â in person again. But for now, Desi and I have this lush landscape, a hawkâs caw, a rabbitâs scamper, a helicopter droning over the city. I have my parents, my wife, and my friends. +
++For now, I have hope. +
++For now, we have each other. +
++Davy Rothbart is the creator of Found magazine, a filmmaker, contributor to This American Life, and author of My Heart Is An Idiot. +
++
++
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+âSir, youâre only allowed one seat, can you please sit up?â +
++The man groans, but remains seated. The Usher becoming impatient with the man, âsir, if you donât get up, I will need to get my manager involvedâ +
++Again the man just groans, which infuriates the Usher as he marches off to get the manager. In a few moments he returns with the manager and they both repeatedly attempt to move him, but with no success. It was at this point that the manager calls the police. +
++Moments later, a police officer arrives and approaches the man, âalright buddy, whatâs your name?â +
++âSamâ the man moans. +
++âAnd where ya from Sam?â +
++With pain in his voice Sam replied, âthe balconyâ. +
+ submitted by /u/Wanan1
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+Itâs the little things that count. +
+ submitted by /u/VERBERD
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+Me: 0mg +
+ submitted by /u/itsaveryshittyname
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+There Once Was A Poet Named Bates, +
++His poems werenât always first rate, +
++His first lines werenât bad, but the problem he had, +
++Was that he always tried to put too many syllables into the last line. +
+ submitted by /u/b_ootay_ful
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+Because he was told his password should contain at least 8 characters and one capital. +
+ submitted by /u/AmilyForChanini
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