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<title>13 June, 2022</title>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>“Any advice for a pre-dad who is freaking out?”: A qualitative analysis of paternal perinatal experiences during the COVID-19 pandemic using the reddit forum predaddit</strong> -
<div>
During the COVID-19 pandemic, new parents were disproportionately affected due to public health restrictions that changed service accessibility and increased stressors. Yet, minimal research to date has examined specific pandemic-related stressors and experiences of perinatal fathers in naturalistic anonymous settings. An important and relatively novel way parents seek connection and information is through online forum use, which increased during the social isolation of the pandemic. The current study qualitatively analyzed the experiences of perinatal fathers from September to December 2020 (792 posts, 8011 comments) through Framework Analytic Approach to identify unmet support needs during COVID-19 using the online subforum, predaddit. Five main themes emergent in the thematic framework included forum use, COVID-19, psychosocial distress, family functioning, and child health and development, each of which contained related subthemes. Findings highlight the utility of predaddit as a source of information for and interactions of fathers to inform mental health services.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/fdh7k/" target="_blank">“Any advice for a pre-dad who is freaking out?”: A qualitative analysis of paternal perinatal experiences during the COVID-19 pandemic using the reddit forum predaddit</a>
</div></li>
<li><strong>Paternal Depression &amp; Anxiety During the COVID-19 Pandemic</strong> -
<div>
COVID-19 influences maternal mental health; however, paternal mental health must be examined. This study describes depression and anxiety and risk/protective factors among fathers of young children. Fathers (N=106) of children 0-8 years old self-reported mental health symptoms, while mothers (N=263) provided paternal depression reports. Fathers evidenced clinically significant depression (37.1%) and anxiety (22.9%), with financial strain and mental health history increasing risk. Maternal-reported paternal depression was prevalent (61.9%) and associated with financial strain, more children, and lower maternal-reported marital quality. Paternal depression and anxiety are elevated versus pre-pandemic comparisons. We must evaluate parental outcomes to promote family well-being and child development.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/drs9u/" target="_blank">Paternal Depression &amp; Anxiety During the COVID-19 Pandemic</a>
</div></li>
<li><strong>The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice</strong> -
<div>
COVID-19 convalescent plasmas (CCPs) are chosen for plasma therapy based on neutralizing titers and anti-Spike immunoglobulin levels. However, specific CCP characteristics that promote SARS-CoV-2 control in recipients are complex and incompletely defined. Using an in vivo imaging approach, we demonstrate that CCPs with low neutralizing and high Fc-effector activity, in contrast to those with poor Fc-function, afford effective prophylaxis and therapy in K18-hACE2 mice lethally challenged with SARS-CoV-2-nLuc. Macrophages and neutrophils significantly contributed to CCP effects during therapy but to a reduced extent under prophylaxis. Both IgG and Ig(M+A) were required during therapy, but the IgG fraction alone was sufficient during prophylaxis. Finally, despite neutralizing poorly, SARS-CoV-2 Wuhan-elicited CCPs delayed Delta and Beta variants of concern (VOC)-induced mortality in mice illustrating the contribution of polyclonal Fc-effector functions in immunity against VOCs. Thus, in addition to neutralization, Fc-effector activity is a significant criterion for CCP selection for therapeutic applications.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.10.495677v1" target="_blank">The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice</a>
</div></li>
<li><strong>Ivermectin for Treatment of Mild-to-Moderate COVID-19 in the Outpatient Setting: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: The effectiveness of ivermectin to shorten symptom duration or prevent hospitalization among outpatients in the United States with mild-to-moderate symptomatic coronavirus disease 2019 (COVID-19) is unknown. Objective: We evaluated the efficacy of ivermectin 400 mcg/kg daily for 3 days compared with placebo for the treatment of early mild-to-moderate COVID-19. Methods: ACTIV-6 is an ongoing, decentralized, double-blind, randomized, placebo-controlled platform trial to evaluate repurposed therapies in outpatients with mild-to-moderate COVID-19. Non-hospitalized adults age &gt;=30 years with confirmed COVID-19, experiencing 2 or more symptoms of acute infection for &lt;=7 days were randomized to receive ivermectin 400 mcg/kg daily for 3 days or placebo. The main outcome measure was time to sustained recovery, defined as achieving at least 3 consecutive days without symptoms. Secondary outcomes included a composite of hospitalization or death by day 28. Results: Of the 3457 participants who consented to be evaluated for inclusion in the ivermectin arm, 1591 were eligible for this study arm, randomized to receive ivermectin 400 mcg/kg (n=817) or placebo (n=774), and received study drug. Of those enrolled, 47% reported receiving at least 2 doses of SARS-CoV-2 vaccination. The posterior probability for any improvement in time to recovery was 0.91 (hazard ratio 1.07, 95% credible interval 0.96 to 1.17). The posterior probability of this benefit exceeding 24 hours was less than 0.01, as measured by the difference in mean time unwell. Hospitalizations or deaths were uncommon (ivermectin [n=10]; placebo [n=9]). Ivermectin at 400 mcg/kg was safe and without serious adverse events as compared with placebo (ivermectin [n=10]; placebo [n=9]). Conclusions: Ivermectin dosed at 400 mcg/kg daily for 3 days resulted in less than one day of shortening of symptoms and did not lower incidence of hospitalization or death among outpatients with COVID-19 in the United States during the delta and omicron variant time periods. Trial registration: ClinicalTrials.gov Identifier: NCT04885530.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.10.22276252v1" target="_blank">Ivermectin for Treatment of Mild-to-Moderate COVID-19 in the Outpatient Setting: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial</a>
</div></li>
<li><strong>Effect of Yoga on the stress, anxiety, and depression of COVID-19 positive patients. A pre-post quasi randomized study.</strong> -
<div>
Background and aim: - Due to the spread of COVID-19 there have been reports of increase in stress, anxiety, and depression across the society, especially so in the affected people, impacting the mental health and well-being. This paper reports a quasi-randomized control study conducted in covid wards of a hospital, to examine the efficacy of add-on yoga intervention in reducing stress, anxiety, and depression in the covid affected patients under quarantine. The oxygen saturation level (SPO2) and heart rate (HR) of the covid affected patients were also measured along with the stress. Experimental procedure: - A total of sixty-two COVID-19 positive patients participated in the study. The participants were randomized into the control group (n=31) which received conventional medical treatment alone and the yoga intervention group (n=31) which additionally received 50 minutes of yoga intervention along with conventional medical treatment. Standardized scales of Hospital Anxiety and Depression Scale (HADS-14), Generalized Anxiety Disorder (GAD-7), Patient Health Questionnaire (PHQ-9) and Perceived Stress Scale (PSS-10) were administered at the beginning as well as at the end of the quarantine period. Results: - A significant decrease in stress, anxiety and depression were observed in the patients who undertook the add-on yoga intervention. Also, improvement in SPO2 and HR levels were observed in the group of patients who were practicing yoga. Conclusion- Findings of this study suggest that add-on Yoga intervention can be an effective add-on practice in reducing stress, anxiety, and depression level of COVID-19 patients.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/2cswy/" target="_blank">Effect of Yoga on the stress, anxiety, and depression of COVID-19 positive patients. A pre-post quasi randomized study.</a>
</div></li>
<li><strong>Evolutionary trajectory of the physicochemical mechanism of interaction of SARS-CoV-2 spike protein with ACE2</strong> -
<div>
SARS-CoV-2 infects cells by attachment to its receptor the angiotensin converting enzyme 2 (ACE2). Regardless of the wealth of structural data, little is known about the physicochemical mechanism of interactions of the viral spike (S) protein with ACE2 and how this mechanism has evolved during the pandemic. Here, we applied experimental and computational approaches to characterize the molecular interaction of S proteins from SARS-CoV-2 variants of concern (VOC). Data on kinetics, activation- and equilibrium thermodynamics of binding of the receptor binding domain (RBD) from VOC with ACE2 as well as data from computational protein electrostatics revealed a profound remodeling of the physicochemical characteristics of the interaction during the evolution. Thus, as compared to RBDs from Wuhan strain and other VOC, Omicron RBD presented as a unique protein in terms of conformational dynamics and types of non-covalent forces driving the complex formation with ACE2. Viral evolution resulted in a restriction of the RBD structural dynamics, and a shift to a major role of electrostatic forces for ACE2 binding. Further, we investigated how the reshaping of the physicochemical qualities affect the functional properties of S proteins. Data from various binding assays revealed that SARS-CoV-2 Wuhan and Omicron RBDs manifest capacity for off-target (promiscuous) recognition of multiple unrelated proteins, but they harbor distinct reactivity patterns. This study provides mechanistic explanations for changes in the viral tropism, infectivity, and capacity to evade immune responses during evolution.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.11.495733v1" target="_blank">Evolutionary trajectory of the physicochemical mechanism of interaction of SARS-CoV-2 spike protein with ACE2</a>
</div></li>
<li><strong>The Effect of Perceived Workplace Bureaucracies on Self-Evaluated Efficacy, Job Satisfaction and Motivation in the Workplace during the COVID-19 Pandemic</strong> -
<div>
Workplace bureaucracies impact many areas of an employee’s life. Perceived high levels of bureaucracy can negatively impact employees’ job motivation, satisfaction, and performance. During the COVID-19 pandemic, infection containment measures may have contributed to the factors underlying the “great resignation” via the lack of self-efficacy from perceived bureaucracy. Recruiting 240 full-time employees in late 2021 to early 2022 across organisations in both private and public sectors in Singapore online with the Work Extrinsic Intrinsic Motivation Scale, the Workplace Bureaucracy Questionnaire and the General Self-Efficacy Scale among demographic parameters, 228 participants were analysed after removal of missing data. Salary range, education levels, employee self-efficacy and job motivation were found to be negatively associated with perceived workplace bureaucracies but not gender, age, and length of service. The findings of the study may provide insight into the mechanism of increased perceived bureaucracy during the COVID-19 pandemic on the employee experience that would be relevant to the workplace environment during in normal times.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/y83ze/" target="_blank">The Effect of Perceived Workplace Bureaucracies on Self-Evaluated Efficacy, Job Satisfaction and Motivation in the Workplace during the COVID-19 Pandemic</a>
</div></li>
<li><strong>Un nuevo urbanismo para Europa: los fondos europeos de recuperación y su proyección en el futuro de las ciudades - A NEW URBANISM FOR EUROPE: THE EUROPEAN RECOVERY FUNDS, AND THEIR IMPACT ON THE FUTURE OF CITIES</strong> -
<div>
The Next Generation EU (NGEU) fund is a European Union economic recovery package to support member states adversely impacted by the COVID-19 pandemic. This program represents an unprecedented effort. Besides promoting a European Union more ecological, digital, and resilient, the recovery funds aim at financing projects of public-private partnership around a series of issues. Some especially related to urbanism, such as ecological transition, smart, sustainable, integrative growth, or social and territorial cohesion. In the first part of the present work, we analyze the evolution of urbanism in Europe since the 1972 European Soil Charter, adopted by the Council of Europe in Strasbourg. Secondly, we examine potential areas where urban projects could be promoted implementing European funds, in connection with the new Leipzig Charter and the European Territorial Agenda 2030, which support an urban environment more just, green, and productive.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/bypk5/" target="_blank">Un nuevo urbanismo para Europa: los fondos europeos de recuperación y su proyección en el futuro de las ciudades - A NEW URBANISM FOR EUROPE: THE EUROPEAN RECOVERY FUNDS, AND THEIR IMPACT ON THE FUTURE OF CITIES</a>
</div></li>
<li><strong>SARS-CoV-2 minor variant genomes at the start of the pandemic contained markers of VoCs</strong> -
<div>
SARS-CoV-2 emerged through limited zoonotic spillovers and was predicted to have constrained sequence diversity. The dominant consensus and minor variant genomes were determined from the earliest samples associated with the Huanan market and the start of the pandemic. The sequence data confirmed that the dominant consensus genomes shared very close homology. However, there were minor variant genomes present in each sample, which encompassed synonymous and non-synonymous changes. Fusion sequences characteristic of defective RNAs were identified that could be linked between patients. Several substitutions (but not deletions) associated with much later variants of concern (VoCs) were already present as minor variant genomes. This suggests it may be possible to predict futures variants at the start of a pandemic by examining where variability in sequence occurs.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.06.10.495670v1" target="_blank">SARS-CoV-2 minor variant genomes at the start of the pandemic contained markers of VoCs</a>
</div></li>
<li><strong>Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection</strong> -
<div>
The global effort to sequence millions of SARS-CoV-2 genomes has provided an unprecedented view of viral evolution. Characterizing how selection acts on SARS-CoV-2 is critical to developing effective, long-lasting vaccines and other treatments, but the scale and complexity of genomic surveillance data make rigorous analysis challenging. To meet this challenge, we develop Bayesian Viral Allele Selection (BVAS), a principled and scalable probabilistic method for inferring the genetic determinants of differential viral fitness and the relative growth rates of viral lineages, including newly emergent lineages. After demonstrating the accuracy and efficacy of our method through simulation, we apply BVAS to 6.9 million SARS-CoV-2 genomes. We identify numerous mutations that increase fitness, including previously identified mutations in the SARS-CoV-2 Spike and Nucleocapsid proteins, as well as mutations in non-structural proteins whose contribution to fitness is less well characterized. In addition, we extend our baseline model to identify mutations whose fitness exhibits strong dependence on vaccination status as well as pairwise interaction effects, i.e. epistasis. Strikingly, both these analyses point to the pivotal role played by the N501 residue in the Spike protein. Our method, which couples Bayesian variable selection with a diffusion approximation in allele frequency space, lays a foundation for identifying fitness-associated mutations under the assumption that most alleles are neutral.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.05.07.490748v2" target="_blank">Inferring selection effects in SARS-CoV-2 with Bayesian Viral Allele Selection</a>
</div></li>
<li><strong>Can starch-based diet or sugar water put an end to the COVID-19 pandemic?</strong> -
<div>
High valine plus glycine content is a feature of the proteins in SARS-CoV-2 and SARS viruses, and it causes the generation of aggregates between proteins and insoluble calcium salts via secondary chemical bonding. Starch-based diet or sugar water with adequate vitamins can go for many days without the generation of essential amino acids such as valine, creating bottlenecks in virion production in human body. Despite its potential carcinogenicity, modest lysine supplement can be favorable as lysine rich proteins gather chloride and solubilize stressful, insoluble and stiff calcium oxalate and calcium phosphate.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/shmk3/" target="_blank">Can starch-based diet or sugar water put an end to the COVID-19 pandemic?</a>
</div></li>
<li><strong>The Prospective Relationship between Loneliness, Life Satisfaction, and Psychological Distress before and during the COVID-19 Pandemic in the UK</strong> -
<div>
Background Mental wellbeing in the UK seems to have deteriorated significantly during the COVID-19 pandemic, with the rates of loneliness, life satisfaction, and psychological distress taking longer to return to the pre-pandemic levels than elsewhere. Nevertheless, there is little knowledge about the interactions between these outcomes, or the factors that played a role. Methods Longitudinal data from Understanding Society (N=3475) were used to explore the changes in loneliness, life satisfaction, and psychological distress from pre-pandemic levels (2017-19) through November 2020, the interactions between these outcomes, and the role of individual differences in the rates of change, using multivariate latent growth curve model. Results Loneliness, life satisfaction, and psychological distress deteriorated minimally between April and November 2020, compared to the pre-pandemic levels (2017-2019), while the rate of change in each outcome influenced the rate of change in the other two. Key individual (age, gender, physical health), social (number of friends) and environmental (neighbourhood quality) variables influenced baseline scores and the rates of change. Conclusion Considering significant dynamic associations between loneliness, life satisfaction, and psychological distress, we argue that interventions to tackle any one of the outcomes may have beneficial effects on others, while highlighting individual and community-level interventions to tackle loneliness.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/5r4vw/" target="_blank">The Prospective Relationship between Loneliness, Life Satisfaction, and Psychological Distress before and during the COVID-19 Pandemic in the UK</a>
</div></li>
<li><strong>Experiences of First Year University Students Regarding Institutional Mentoring Programme during COVID-19 Outbreak: A Qualitative Evidence Synthesis</strong> -
<div>
Universities had to ensure that students were well supported during the COVID-19 pandemic. Over the years, peer mentors have provided one-on-one psychosocial support to first-year students. Following the outbreak of COVID-19, it became difficult to provide face-to-face assistance. As a result, new forms of communities, networks, and interactions, that student can develop and participate in, emerged to cope with the crisis. The problem is that students encounter unexpected challenges from the moment they arrive at university, owing to the substantial shift in roles and complex responsibilities that comes with being a student at a university. The purpose of this study is to investigate students’ first-year experiences during the COVID-19 outbreak so as to provide insights that could be useful for institutional policy and practice. The study was undertake a Qualitative Evidence Systematic Review, which is a summary of research literature focused on a single subject that claims the role of systematic reviews in evidence-based practices. A qualitative meta-synthesis was conducted using the PICO framework (Population/Place; Intervention; Comparator; Outcome) so as to seek to answer the question: “What are the experiences of first-year university students regarding the institutional mentoring programme during the Covid-19 Outbreak?” Articles were critically reviewed for eligibility using the PRISMA flow diagram, with relevance screening and duplicate removal using the CASP assessment tool. This is a method that allows the researcher to evaluate data both deductively and interpretively to better understand phenomena. In total fifteen articles were selected for this study; they were chosen through purposive sampling and then subjected to thematic analysis. The findings of this study are expected to add to the existing body of knowledge on the first-year university student experience.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/africarxiv/ajmkp/" target="_blank">Experiences of First Year University Students Regarding Institutional Mentoring Programme during COVID-19 Outbreak: A Qualitative Evidence Synthesis</a>
</div></li>
<li><strong>The impact of COVID-19 pandemic on bronchiolitis (lower respiratory tract infection) due to respiratory syncytial virus: A systematic review and meta-analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Objective This systematic review and meta-analysis aimed to quantitatively evaluate the effect of the COVID-19 pandemic on respiratory syncytial virus (RSV) associated bronchiolitis among hospitalised infants. Methods The study protocol was registered in the PROSPERO database (CRD42022314000) and was designed based on PRISMA guidelines updated in May 2020. The meta-analysis component was modified appropriately to synthesise the pooled proportion of infants having RSV-associated bronchiolitis before the COVID-19 pandemic in 2019 and during the pandemic with 95% confidence interval (CI). Results: The eight qualified studies for the meta-analysis were from Spain, Italy, France and China, including 109,186 symptomatic cases of bronchiolitis before the pandemic in 2019 and 61,982 cases in 2020-2021. The quantitative analysis included laboratory-confirmed RSV infection in 7691 infants with bronchiolitis reported before the pandemic in 2019. Meanwhile, during the pandemic, 4964 cases were associated with RSV infection. The pooled proportion of RSV-associated bronchiolitis cases before the pandemic in 2019 was 16.74% (95% CI 11.73-22.43%). The pooled proportion of confirmed RSV cases during the pandemic in 2020/2021 was 19.20 % (95% CI 12.01-27.59%). Conclusion There was an increase in RSV activity after the relaxation of stringent public health measures during the COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.04.26.22274244v6" target="_blank">The impact of COVID-19 pandemic on bronchiolitis (lower respiratory tract infection) due to respiratory syncytial virus: A systematic review and meta-analysis</a>
</div></li>
<li><strong>The impact of COVID-19 pandemic on influenza surveillance: a systematic review and meta-analysis</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Influenza activity was reported to be below the seasonal levels during the COVID-19 pandemic globally. However, during the SARS-CoV-2 outbreak, the routine real-time surveillance of influenza like illness (ILI) and acute respiratory infection (ARI) was adversely affected due to the changes in priorities, economic constraints, repurposing of hospitals for COVID care and closure of outpatient services. A systematic review and meta-analysis were carried out to assess the pooled proportion of symptomatic cases tested for influenza virus before the COVID-19 pandemic in 2019 and during the pandemic in 2020/2021. The study was designed based on PRISMA guidelines and the meta-analysis was performed to synthesise the pooled proportion of patients sampled for influenza surveillance before the COVID-19 pandemic in 2019 and during the pandemic in 2020/21 with 95% confidence interval (CI). The overall pooled proportion of symptomatic cases undergone influenza surveillance before and during the pandemic was 2.38% (95% CI 2.08%-2.67%) and 4.18% (95% CI 3.8%-4.52%) respectively. However, the pooled proportion of samples tested for influenza before the pandemic was 0.69% (95% CI 0.45-0.92%) and during the pandemic was 0.48% (95% CI 0.28-0.68%) when studies from Canada were excluded. The meta-analysis concludes that globally there was a decline in influenza surveillance during the COVID-19 pandemic except in Canada.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.31.22273236v4" target="_blank">The impact of COVID-19 pandemic on influenza surveillance: a systematic review and meta-analysis</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase I Clinical Trial of GEN2-Recombinant COVID-19 Vaccine (CHO Cells) in Healthy People Aged 18 and Above</strong> - <b>Condition</b>:   COVID-19 Pneumonia<br/><b>Interventions</b>:   Biological: Experimental Vaccine 1;   Biological: Experimental Vaccine 2;   Biological: Experimental Vaccine 3;   Biological: placebo<br/><b>Sponsors</b>:   National Vaccine and Serum Institute, China;   Lanzhou Institute of Biological Products Co., Ltd;   Beijing Institute of Biological Products Co Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 Algorithm Treatment at Home</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Recommended treatment schedule;   Drug: Usual care<br/><b>Sponsor</b>:   Mario Negri Institute for Pharmacological Research<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Eucalyptus Oil as Adjuvant Therapy for Coronavirus Disease 19 (COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Eucalyptus Oil;   Drug: Standard COVID medication<br/><b>Sponsors</b>:   Hasanuddin University;   Ministry of Agriculture, Republic of Indonesia<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study of Oral High/Low-dose Cepharanthine Compared With Placebo in Non Hospitalized Adults With COVID-19</strong> - <b>Condition</b>:   Asymptomatic COVID-19<br/><b>Interventions</b>:   Drug: Cepharanthine;   Drug: Placebo<br/><b>Sponsors</b>:   Shanghai Jiao Tong University School of Medicine;   YUNNAN BAIYAO GROUP CO.,LTD<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Epidemiological Monitoring of COVID-19 Patients Hospitalized on Reunion Island</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: telephone interview 24 months after hospitalization for Covid-19<br/><b>Sponsor</b>:   Centre Hospitalier Universitaire de la Réunion<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Real-time Quaking-Induced Conversion (RT-QuIC)<br/><b>Sponsor</b>:   Medical University Innsbruck<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Randomized, Single-blinded, Multicenter Trial Comparing the Immune Response to a 2nd Booster Dose of COVID-19 mRNA Vaccine (Pfizer-BioNTech) or Sanofi /GSK B.1.351 Adjuvanted Vaccine in Adults</strong> - <b>Condition</b>:   COVID-19 Vaccines<br/><b>Interventions</b>:   Biological: 2nd booster with Comirnaty® (Pfizer-BioNTech);   Biological: CoV2 preS dTM adjuvanted vaccine (B.1.351), Sanofi/GSK<br/><b>Sponsors</b>:   Assistance Publique - Hôpitaux de Paris;   IREIVAC/COVIREIVAC Network<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety of a Third Dose of COVID-19 Vaccine(Vero Cell), Inactivated in the Elderly</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: COVID-19 Vaccine (Vero cell), Inactivated<br/><b>Sponsor</b>:   Sinovac Life Sciences Co., Ltd.<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy, Safety and Immunogenicity Study of the Recombinant Two-component COVID-19 Vaccine (CHO Cell)(Recov)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Recombinant two-component COVID-19 vaccine (CHO cell);   Biological: Placebo<br/><b>Sponsor</b>:   Jiangsu Rec-Biotechnology Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Immunogenicity and Safety Study of Booster Vaccine With the COVID-19 Vaccine (Vero Cell), Inactivated, Omicron Strain</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: COVID-19 Vaccine (Vero Cell), Inactivated, Omicron Strain<br/><b>Sponsor</b>:   Sinovac Biotech (Hong Kong) Limited<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase 1b Trial to Evaluate the Safety and Immunogenicity of a SARS-CoV-2 mRNA Chimera Vaccine Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: RQ3013;   Biological: Comirnaty<br/><b>Sponsors</b>:   Walvax Biotechnology Co., Ltd.;   Shanghai RNACure Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Plerixafor in Acute Respiratory Distress Syndrome Related to COVID-19 (Phase IIb)</strong> - <b>Conditions</b>:   COVID-19 Acute Respiratory Distress Syndrome;   COVID-19<br/><b>Interventions</b>:   Drug: Plerixafor 20 MG/ML [Mozobil];   Other: Placebo<br/><b>Sponsor</b>:   4Living Biotech<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effects of Telerehabilitative Aerobic and Relaxation Exercises Patients With Type 2 Diabetes With and Without COVID-19</strong> - <b>Conditions</b>:   COVID-19;   Type 2 Diabetes Mellitus<br/><b>Intervention</b>:   Other: Aerobic and Relaxation Exercises<br/><b>Sponsor</b>:   Bozyaka Training and Research Hospital<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of Bradykinin in COVID-19 Infection With Icatibant</strong> - <b>Condition</b>:   SARS CoV 2 Infection<br/><b>Interventions</b>:   Drug: Icatibant;   Drug: 0.9% Sodium Chloride Injection<br/><b>Sponsors</b>:   Belfast Health and Social Care Trust;   Queen’s University, Belfast<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Effect of Prone Positioning on the Severity of COVID-19 Pneumonia and Acute Respiratory Distress Syndrome.</strong> - <b>Conditions</b>:   COVID-19 Acute Respiratory Distress Syndrome;   COVID-19 Pneumonia;   Prone Positioning<br/><b>Intervention</b>:   Other: Prone Positioning Maneuver<br/><b>Sponsors</b>:   Ayub Medical College, Abbottabad;   Ayub Teaching Hospital<br/><b>Completed</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The use of ivermectin for the treatment of COVID-19: Panacea or enigma?</strong> - The outbreak of SARS-CoV-2 pandemic has triggered unprecedented social, economic and health challenges. To control and reduce the infection rate, countries employed non-pharmaceutical measures such as social distancing, isolation, quarantine, and the use of masks, hand and surface sanitisation. Since 2021 a global race for COVID-19 vaccination ensued, mainly due to a lack of equitable vaccine production and distribution. To date, no treatments have been demonstrated to cure COVID-19. The…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sewage surveillance for SARS-CoV-2: Molecular detection, quantification, and normalization factors</strong> - The presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in wastewater systems provides a primary indication of the coronavirus disease 2019 (COVID-19) spread throughout communities worldwide. Droplet digital polymerase chain reaction (dd-PCR) or reverse transcription-polymerase chain reaction (RT-PCR) administration of SARS-CoV-2 in wastewaters provides a reliable and efficient technology for gathering secondary local-level public health data. Often the accuracy of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>C/EBPα Epigenetically Modulates <em>TFF1</em> Expression <em>via</em> mC-6 Methylation in the Jejunum Inflammation Induced by a Porcine <em>Coronavirus</em></strong> - Porcine epidemic diarrhea virus (PEDV) is an emerging coronavirus which causes acute diarrhea and destroys gastrointestinal barrier function in neonatal pigs. Trefoil factor 1 (TFF1) is a protective peptide for maintaining the integrity of gastrointestinal mucosa and reducing intestinal inflammation. However, its role in protecting intestinal epithelium against PEDV infection is still unclear. In this study, we discovered that TFF1 expression was activated in the jejunum of pigs with PEDV…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Impact of Thermal Pretreatment of Saliva on the RT-PCR Detection of SARS-CoV-2</strong> - The use of saliva directly as a specimen to detect viral RNA by RT-PCR has been tested for a long time as its advantages are relevant in terms of convenience and costs. However, as other body fluids, its proven inhibition effect on the amplification reaction can be troublesome and compromise its use in the detection of viral particles. The aim of the present work is to demonstrate that saliva pretreatment may influence the RT-PCR amplification of three gene targets of SARS-CoV-2 significantly. A…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pralatrexate for Peripheral T-cell lymphoma (PTCL): Chance only supports the prepared mind. Systematic review</strong> - CONCLUSION: While there are manageable side effects such as thrombocytopenia, neutropenia, and mucositis, it is critical to explore new approaches, targeted agents, novel cellular therapies, and immunotherapies to determine optimal pretreatment in the rare but heterogeneous disease PTCL, and future studies and experienced haematologists are needed.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antivirals and the Potential Benefits of Orally Inhaled Drug Administration in COVID-19 Treatment</strong> - Coronavirus Disease 2019 (COVID-19) pandemic has been on the agenda of humanity for more than 2 years. In the meantime, the pandemic has caused economic shutdowns, halt of daily lives and global mobility, overcrowding of the healthcare systems, panic, and worse, more than 6 million deaths. Today, there is still no specific therapy for COVID-19. Research focuses on repurposing of antiviral drugs that are licensed or currently in the research phase, with a known systemic safety profile. However,…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Conserved coronavirus proteins as targets of broad-spectrum antivirals</strong> - Coronaviruses are a class of single-stranded, positive-sense RNA viruses that have caused three major outbreaks over the past two decades: Middle East respiratory syndrome-related coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). All outbreaks have been associated with significant morbidity and mortality. In this study, we have identified and explored conserved binding sites in the key coronavirus…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Combined exploration of the mechanism of Sang Xing Decoction in the treatment of smoke-induced acute bronchitis from protein and metabolic levels</strong> - Sang Xing decoction (SXD) is a typical prescription for treating “warm dryness” in traditional Chinese medicine (TCM), which is equivalent to respiratory diseases such as acute bronchitis in modern medicine. However, its mechanism of action remains unclear. In this study, the representative components of SXD were characterized using liquid chromatography-tandem mass spectrometry (LC-MS). The key targets, signaling pathways, and metabolic pathways associated with SXD in the treatment of acute…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virus</strong> - CONCLUSIONS: GMI prevents SARS-CoV-2 pseudovirus infection via induction of ACE2 degradation in host cells. Our findings suggest that GMI will be a potential prevention agent to alleviate SARS-CoV-2 infection.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Prevalence of alcohol-tolerant and antibiotic-resistant bacterial pathogens on public hand sanitizer dispensers</strong> - CONCLUSION: HSDs serve as potential breeding grounds for dissemination of pathogens and antibiotic resistance across unknowing users. Proper HSD maintenance will ensure protection of public health and sustainable use of sanitizing alcohols, to prevent emergence of alcohol-resistant pathogens.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Risk stratification models for stroke in patients hospitalized with COVID-19 infection</strong> - CONCLUSIONS: We developed a practical clinical score, with similar performance to machine learning estimators, to help stratify stroke risk among patients hospitalized with COVID-19.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The spike glycoprotein of highly pathogenic human coronaviruses: structural insights for understanding infection, evolution and inhibition</strong> - Highly pathogenic human coronaviruses (CoV) including SARS-CoV, MERS-CoV and SARS-CoV-2 have emerged over the past two decades, resulting in infectious disease outbreaks that have greatly affected public health. The CoV surface spike (S) glycoprotein mediates receptor binding and membrane fusion for cell entry, playing critical roles in CoV infection and evolution. The S glycoprotein is also the major target molecule for prophylactic and therapeutic interventions, including neutralizing…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inhibition of SARS-CoV-2 pathogenesis by potent peptides designed by the mutation of ACE2 binding region</strong> - The outbreak of COVID-19 has resulted in millions of deaths. Despite all attempts that have been made to combat the pandemic, the re-emergence of new variants complicated SARS-CoV-2 eradication. The ongoing global spread of COVID-19 demands the incessant development of novel agents in vaccination, diagnosis, and therapeutics. Targeting receptor-binding domain (RBD) of spike protein by which the virus identifies host receptor, angiotensin-converting enzyme (ACE2), is a promising strategy for…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Discovery of novel SARS-CoV-2 inhibitors targeting the main protease M<sup>pro</sup> by virtual screenings and hit optimization</strong> - Two years after its emergence, SARS-CoV-2 still represents a serious and global threat to human health. Antiviral drug development usually takes a long time and, to increase the chances of success, chemical variability of hit compounds represents a valuable source for the discovery of new antivirals. In this work, we applied a platform of variably oriented virtual screening campaigns to seek for novel chemical scaffolds for SARS-CoV-2 main protease (M^(pro)) inhibitors. The study on the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators</strong> - BACKGROUND: Bromodomain and extraterminal proteins (BETs) are more than just epigenetic regulators of transcription. Here we highlight a new role for the BET protein BRD4 in the maintenance of higher order chromatin structure at Topologically Associating Domain Boundaries (TADBs). BD2-selective and pan (non-selective) BET inhibitors (BETi) differentially support chromatin structure, selectively affecting transcription and cell viability.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dishonor, Trump’s and His Party’s, Is the Real January 6th Takeaway</strong> - Liz Cheney, defying the G.O.P., offered a searing indictment of the former President at Thursday’s hearing. - <a href="https://www.newyorker.com/news/letter-from-bidens-washington/dishonor-trumps-and-his-partys-is-the-real-january-6th-takeaway">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why San Francisco Fired Chesa Boudin</strong> - Does the district attorney’s recall reveal the limitations of progressive criminal-justice reform? - <a href="https://www.newyorker.com/news/the-political-scene/why-san-francisco-fired-chesa-boudin">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hiding Buffalo’s History of Racism Behind a Cloak of Unity</strong> - Officials have described the recent shooting as an aberration in the “City of Good Neighbors.” But this conceals the city’s long-standing racial divisions. - <a href="https://www.newyorker.com/news/our-columnists/hiding-buffalos-history-of-racism-behind-a-cloak-of-unity">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Gun Scare at the Anti-Gun Rally</strong> - At the March for Our Lives, in Washington, D.C., a man yelled that he had a gun, sending attendees scrambling. For one local family, it was just more of the same. - <a href="https://www.newyorker.com/news/dispatch/a-gun-scare-at-the-anti-gun-rally">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>André Alexis Reads “Houyhnhnm”</strong> - The author reads his story from the June 20, 2022, issue of the magazine. - <a href="https://www.newyorker.com/podcast/the-writers-voice/andre-alexis-reads-houyhnhnm">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Finding a new job is possible — even when you’re burned out</strong> -
<figure>
<img alt="A cartoon illustration of a computer screen showing a person on a videoconference call." src="https://cdn.vox-cdn.com/thumbor/luYtphzSNQQmGLDgBcX49H0Dqpw=/250x0:2501x1688/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70970321/burnout.0.png"/>
<figcaption>
Shanée Benjamin for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Looking for a new job doesn’t have to be just another exhausting to-do list item.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kAQZ1H">
It’s an ironic Catch-22: Your job is sapping your energy to the point where you can’t muster the strength to look for a new one. So what are you supposed to <em>do?</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t45DGK">
One of the most considerable issues with modern work is pervasive burnout. According to <a href="https://mpleiter.com/">Michael Leiter</a>, co-author of the upcoming book <a href="https://www.hup.harvard.edu/catalog.php?isbn=9780674251014"><em>The Burnout Challenge: Managing People’s Relationships With Their Jobs</em></a>, the core aspects of burnout are feeling exhausted, cynical, and discouraged. Last year, 71 percent of workers reported experiencing work-related stress, according to the American Psychological Association’s <a href="https://www.apa.org/pubs/reports/work-well-being/compounding-pressure-2021">2021 Work and Well-being Survey</a>. Three in five employees said they experienced negative impacts at work from stress; the top impacts reported were lack of interest, motivation, or energy; difficulty focusing; and lack of effort at work — all <a href="https://www.mayoclinic.org/healthy-lifestyle/adult-health/in-depth/burnout/art-20046642">symptoms of burnout</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ALnfrF">
Workplace burnout isn’t a byproduct of the pandemic; this specific breed of exhaustion predates it. The term <a href="https://journals.sagepub.com/doi/pdf/10.1177/2158244017697154">first became popularized in the 1970s</a> to describe the exhaustion human services workers experienced. Over the ensuing decades, burnout has been shown to <a href="https://www.tandfonline.com/doi/full/10.1080/1359432X.2021.1979962">exist in nearly every profession</a>, was <a href="https://www.who.int/news/item/28-05-2019-burn-out-an-occupational-phenomenon-international-classification-of-diseases">classified as an occupational phenomenon</a> by the World Health Organization, and was famously named a <a href="https://www.vox.com/policy-and-politics/21473579/millennials-great-recession-burnout-anne-helen-petersen">hallmark of the millennial generation</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GNY0KB">
If your job is contributing — or is the sole contributor — to your burnout, you may feel pulled to search for greener pastures. But when you’re burned out, completing even the smallest of tasks, let alone a massive undertaking like a job search, can be daunting. “Looking for jobs is one of the hardest jobs there is,” Leiter says. “You’ve got to figure out how you’re going to put your energy together for that.” There are steps you can take to preserve your energy and look for your next role regardless of industry.
</p>
<h3 id="ZIGl3m">
Get to the root of your burnout
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2YGkWv">
Before jumping onto job boards, first determine <a href="https://hbr.org/2019/07/6-causes-of-burnout-and-how-to-avoid-them">what’s causing your burnout</a>, says workplace well-being expert <a href="https://www.jennifer-moss.com/">Jennifer Moss</a>, author of <a href="https://bookshop.org/books/the-burnout-epidemic-the-rise-of-chronic-stress-and-how-we-can-fix-it/9781647820367"><em>The Burnout Epidemic: The Rise of Chronic Stress and How We Can Fix It</em></a>. When you narrow in on why you’re so stressed, you can avoid entering another workplace culture that perpetuates the same issues. Is your workload too overwhelming, or so light you’re feeling bored and unfulfilled? Do you feel lonely and alienated from your colleagues? Are you being overlooked for promotions and raises? These topics are worth discussing with your current manager, Moss says, and can be addressed by fixes like limiting meetings, triaging important tasks, reconnecting with colleagues, having more control over your schedule, and fostering more communication with your manager (however, this will only be successful if your manager meets you halfway). Ideally, your boss will be receptive to your concerns and you won’t need to leave your job. “What are you looking for?” Moss says. “Because it isn’t going to be easy starting a brand new job, especially if you’re burned out.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oOGntx">
Of course, if the workplace is truly toxic, you should feel empowered to quit. An <a href="https://sloanreview.mit.edu/article/why-every-leader-needs-to-worry-about-toxic-culture/">MIT Sloan Management Review analysis</a> of Glassdoor reviews found the top five descriptors of toxic workplaces were “disrespectful,” “non-inclusive,” “unethical,” “cutthroat,” and “abusive.” <a href="https://www.shrm.org/resourcesandtools/hr-topics/benefits/pages/shrm-study-greater-mental-health-challenges.aspx">Women</a>, <a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775738">LGBTQ people</a>, and <a href="https://www.eurekalert.org/news-releases/614959">people</a> <a href="https://utpjournals.press/doi/abs/10.3138/jehr-2021-0007">of</a> <a href="https://journals.sagepub.com/doi/abs/10.1177/00957984211033963">color</a> face systemic and structural issues in workplaces that further contribute to burnout. While quitting an unhealthy job without another offer is a privilege not everyone has, if your mental health is being seriously impacted, “we always have the option to leave,” Moss says.
</p>
<h3 id="bESL9W">
Do some soul-searching
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bZQ9cO">
If you’ve decided to find a new job, it’s helpful to determine what an ideal next position looks like for you in order to avoid getting overwhelmed by the deluge of job listings. To help workers envision their ideal working conditions, Leiter recommends reflecting on your current (or most recent, if you’re unemployed) workday for a week or so, making mental notes of the moments where you felt happy and fulfilled: What were you doing? Who were you working with? Who weren’t you working with?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MJZBrR">
Then, Leiter says, think about the situations where you disliked the job: What were the most tedious moments? What overwhelmed you the most? What was the worst part of the day? What projects or situations gave you the Sunday scaries? “It could be just as simple as, ‘This job requires a lot of travel that takes me away from my family and I hate that,’” Leiter says. ”It could be, ‘People interrupt me all day. I hate it when people interrupt me.’”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="s5os9F">
Instead of looking for narrow skills or specifications in job listings, identify roles and companies that align with your values and well-being, Moss says. All of the factors initially contributing to your burnout can help guide you. For instance, if you’re burned out by isolation, you might want to look for a workplace with a hybrid approach so you can interact with colleagues face-to-face a few days a week. Or if your concern is with workload, perhaps a scrappy startup with a small team won’t be the best fit. “A lot of it is looking for mental health goals and priorities versus some of the other compensation factors that we might have looked for before,” Moss says.
</p>
<h3 id="ZExGni">
Break down the job search
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="R0idtb">
The job search process can be long and arduous. Updating your resume, scouring job listings, writing cover letters, scheduling informational interviews, going on actual interviews, completing skills assessments, and then waiting patiently for updates is a lot even for people who aren’t burned out.
</p>
<div class="c-float-right">
<aside id="5HNp06">
<q>“Looking for jobs is one of the hardest jobs there is”</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Uxsifx">
Don’t be demoralized by the path to employment and instead break down the process into bite-size milestones: Give yourself 30-, 60-, and 90-day goals, says <a href="https://www.mindaharts.com/">Minda Harts</a>, workplace equity consultant and author of <a href="https://www.sealpress.com/titles/minda-harts/the-memo/9781580058452/"><em>The Memo: What Women of Color Need to Know to Secure a Seat at the Table</em></a>. During the first 30 days of your search, consider your values and what you’d like your next role to look like. Another 30-day goal is to <a href="https://www.themuse.com/advice/10-resume-resources-thatll-make-it-almost-impossible-for-a-hiring-manager-to-pass">work</a> on <a href="https://www.ziprecruiter.com/blog/resume-101-4-things-you-must-include/">your</a> <a href="https://www.resumebuilder.com/resume-examples/">resume</a>, Harts says, whether you’re devoting a few hours a week to sprucing it up (college and university career centers often have <a href="https://careercenter.umich.edu/article/resume-resources">free</a> <a href="https://career.berkeley.edu/Tools/Resume">resume</a> <a href="https://www.bc.edu/content/bc-web/offices/student-affairs/sites/careers/jobs-internships/resumes.html">writing</a> <a href="https://careers.umd.edu/find-jobs-internships/resumes-cover-letters/resume-how-to-guide">resources</a> <a href="https://career.virginia.edu/resumes">online</a>) or hiring a resume writer, if you can afford one. Sixty-day goals can include reaching out to folks who work in interesting positions or companies for short informational interviews. By 90 days, you should be applying for jobs. “I’m breaking it down, but I don’t feel overwhelmed,” Harts says. “I’m still able to heal during this process and get healthier because you want to be healthy while you’re job-seeking.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rEqCDg">
While you’re taking on the extra burden of looking for a new job, you’re going to need to outsource some other tasks to create mental space. Harts suggests asking a partner or loved one if they can pick up the kids from day care a few times a week or take on extra chores around the house. You can also work with a <a href="https://hbr.org/2022/02/do-you-need-a-career-coach">career coach</a> who can make the ordeal feel less overwhelming and isolating. Again, working with an expert will come with a price tag — anywhere from <a href="https://www.indeed.com/career-advice/career-development/how-much-does-career-coaching-cost">$100 to $150 per session</a> — which not everyone can afford, but if you go that route, <a href="https://www.themuse.com/advice/how-to-choose-the-right-career-coach-for-you">look for people</a> with personality types you work well with and coaches with expertise in the field or industry where you’re looking to find a job.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dNerXP">
Moss also recommends pairing applying for jobs with a pleasurable activity, like sipping a comforting cup of tea while firing off resumes. “You’re taking a moment to do something that engages those pleasure centers of your brain and then you’re doing something that feels like it’s productive,” she says. Don’t apply for jobs during work hours or on a company-issued laptop or phone, Moss continues, and don’t let applying eat too much into your personal time, either — just keep it to contained moments of the duration of your warm beverage or the time it takes the sun to set.
</p>
<h2 id="lCJgGU">
Make the most of the interview
</h2>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Maw4ig">
Under ordinary circumstances, it’s crucial to come to the table prepared with questions for your interviewer — it’s your chance to figure out if the role and the company are a good fit, after all. When you’re dealing with burnout, it’s even more important to use the Q&amp;A portion to ask pointed questions about culture. Without mentioning burnout outright, you can ask about office self-care practices, paid time off, flexible scheduling, and remote work. “You can get down to the question without actually coming out and saying, ‘Hey, are your employees experiencing burnout?’” Harts says. “You can position the burnout conversation around wellness.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="AZgz4P">
If your boss contributed to your burnout, you can ask about management style or team dynamics, Harts says. If the job listing mentioned flexible scheduling, ask what such flexibility looks like in practice. “Because maybe my last company’s flexibility was working five days a week in the office instead of seven,” Harts says, “so that’s not very flexible.” Moss recommends other sneaky questions worth asking to get to the root of burnout culture: “What are the company’s mental health benefits?” “How does the company build supportive working relationships?” “Tell me about the company’s employee resource groups.” “How are goals met? Are there individual or shared goals?” (Individual goals are more likely to lead to burnout, Moss says.)
</p>
<h2 id="DgiNa6">
Manage rejection
</h2>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UPLRmr">
Rejection is, unfortunately, a requisite part of job searching. When you’re burned out and already contending with a defeatist attitude, rolling with the punches is much more difficult. Acknowledge the feelings of hurt and disappointment, Harts says. “Sometimes it’s easy for us to sweep them under the rug or we dwell on them too much,” she says, “which could create forms of impostor syndrome where we’re starting to gaslight ourselves about the situation.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UGGHmy">
Then, acknowledge your limited control in the interview process and focus on the areas within your power, like which jobs you apply for and how prepared you are for each interview. “I can’t control if this company hires me or calls me back,” Harts says. “We have to remind ourselves, <em>What part of this equation can I control?</em> and I’m going to lean into that. I’m not going to allow myself to overwhelm myself additionally, or gaslight myself additionally by wondering if I’m good enough.”
</p>
<h3 id="zKbeYS">
Don’t bring burnout into your next role
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0IOnA6">
Once you’ve landed a position, the last thing you want to do is bring burnout into your new job. Experts agree taking time off to recharge, log off, and rest is the best way to heal from burnout, so if you can afford to take a couple of weeks to invest in rest, you should. But many workers don’t have the option to forgo work for an extended period. In the absence of a transitory break, Leiter suggests partaking in a reenergizing activity — meditating, reading, spending time with friends — and reflecting on what excites you about work in the first place.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uXhMtQ">
Harts also recommends having a conversation with your future manager to set boundaries, whether that’s determining how many days you’re able to come into the office, hours and days a week you’re able to work, flexibility when it comes to scheduling, or the after-hours email and chat expectations.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FeIG1j">
The goal, Moss says, is to prioritize yourself instead of your work. The best-laid plan for plotting a job change while burned out is one with your needs and values at the center, orchestrated in small, but meaningful, steps.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gvSqXq">
“After two years of facing our own mortality, our identity with work has really changed and our priorities have changed,” Moss says. “How important is work? Is it worth my health? Is it worth my happiness? If the answer is no, you want to think clearly about what the plan is to make that more of a priority.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="D1uGEM">
<a href="http://www.vox.com/even-better"><em>Even Better</em></a><em> is here to offer deeply sourced, actionable advice for helping you live a better life. Do you have a question on money and work; friends, family, and community; or personal growth and health? Send us your question by filling out this </em><a href="https://docs.google.com/forms/d/e/1FAIpQLSfiStGSlsWDBmglim7Dh1Y9Hy386rkeKGpfwF6BCjmgnZdqfQ/viewform"><em>form</em></a><em>. We might turn it into a story.</em>
</p></li>
<li><strong>What’s in the bipartisan plan for gun control</strong> -
<figure>
<img alt="March for our Lives holds D.C. event as lawmakers mull bipartisan gun control measures" src="https://cdn.vox-cdn.com/thumbor/K3Nf5mJbdeOr4f9NPMMYqPVOPxw=/243x0:4126x2912/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70969216/1241255155.0.jpg"/>
<figcaption>
A recent March for our Lives event in Washington, D.C. illustrates the ongoing outrage over lawmakers’ lack of response to mass shootings. | Amanda Andrade-Rhoades via Getty Images
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The forthcoming bipartisan agreement could be the first new gun control laws enacted in decades.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FRdAvU">
A bipartisan group of senators on Sunday <a href="https://www.washingtonpost.com/politics/2022/06/12/senate-gun-deal-framework/">announced a framework for federal gun control legislation</a>, a remarkable breakthrough after years of stasis and obstruction on the part of Republican senators to pass any restrictions on gun ownership. Despite the bipartisan cooperation, the framework is not yet formal legislation — and focuses primarily on mental health and school security interventions, rather than meaningfully restricting access to firearms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2lne0a">
The announcement comes after two horrific mass shootings: one at a grocery store in Buffalo, New York, which killed 10, and the other at an elementary school in <a href="https://www.vox.com/2022/6/12/23157849/teachers-school-shootings-uvalde-texas">Uvalde, Texas</a>, which killed 19 children. As mass-casualty events continue to mount, the country has seen a renewed demand for a significant response on the federal level. March for Our Lives, the gun control activism group founded after the deadly shooting in Parkland, Florida in 2018, <a href="https://www.cnn.com/2022/06/11/politics/march-for-our-lives-dc/index.html">held a rally in Washington, DC on Saturday</a>, calling for congressional action in the wake of the recent shootings.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YrTrH0">
“The injustices we see on the daily are being blatantly ignored by those on Capitol Hill. The cries of the nation’s children can be heard across the world, and you choose to turn a blind eye and a deaf ear to the lives being taken,” March for our Lives board member Trevon Bosley said in a speech during Saturday’s rally, highlighting the lack of political will to pass federal gun control legislation even during the wake of the Parkland shootings, which killed 17. “Your job is to represent and serve all the people who call this country home, and so far you’ve shown us you only represent the pockets of whoever donates the most to your campaign,” Bosley said.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BH7bkO">
Parkland survivor X González echoed that sentiment in an interview with <a href="https://www.theatlantic.com/politics/archive/2022/06/x-gonzalez-parkland-mass-shooting-gun-violence/661244/">the Atlantic</a> about their return to activism after the Buffalo and Uvalde shootings. “I definitely lay the blame on the naysayers within Congress who are against passing gun laws for any reason,” they told interviewer Elaine Godfrey. “They legitimately somehow believe that having guns will make people safer, which has <a href="https://www.hsph.harvard.edu/news/hsph-in-the-news/scientists-agree-guns-dont-make-society-safer/">statistically proven</a> over years and years and years to have especially negatively impacted children. Or they just don’t seem to care.” In 2020, the latest year for which there is data, <a href="https://wisqars.cdc.gov/data/explore-data/explore/selected-years?ex=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%3D">4,368 children 19 and under</a> were killed by firearms in the US, making <a href="https://www.axios.com/2022/05/26/gun-deaths-children-america">firearms the leading cause of death for this age group</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ALxrdJ">
While the legislative framework introduced Sunday is nowhere near what activists and President Joe Biden are calling for, there is a sense that the announcement is the step in the right direction; as Gonzáles said in their Atlantic interview, “It’s definitely a start. We’ve got to begin somewhere.”
</p>
<h3 id="OM0w91">
The framework has a heavy focus on mental health and school interventions
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1nTqKt">
Perhaps what is most surprising about the framework is that it exists at all, and that it’s the product of a bipartisan group of legislators — Sens. Chris Murphy (D-CT), Kyrsten Sinema (D-AZ), John Cornyn (R-TX), Thom Tillis (R-NC), are the lead negotiators on the framework, with a larger group including Sens. Susan Collins (R-ME), Chris Coons (D-DE), Martin Heinrich (D-NM), and Lindsey Graham (R-SC) also engaged in talks.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BLvbOx">
The framework itself is heavy on mental health interventions, like setting aside funding for in-school mental health and support services, as well as telehealth services for individuals and families in mental health crisis. It also calls for a national expansion of community mental health services for children and families.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="3UOqwa">
Those measures echo some of the right-wing talking points that have historically emerged after past mass shooting incidents — that guns are not responsible for gun deaths, but instead, mental illness, the perceived lack of Christian influence on society, inadequate school security, and <a href="https://citationsneeded.libsyn.com/news-brief-rightwing-medias-increasingly-goofy-hyper-militarized-non-solutions-to-mass-shootings">a host of other social ills are to blame</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="C7S5w5">
While expanding access to and investment in mental health services is useful regardless of the reason, that alone can’t stop mass shootings. Nor can the proposed expansion of security measures in schools; although <a href="https://www.murphy.senate.gov/newsroom/press-releases/bipartisan-group-of-senators-announce-agreement">the framework</a> is thin on details, it suggests investing in “programs to help institute safety measures in and around primary and secondary schools, support school violence prevention efforts and provide training to school personnel and students.” Theoretically, that could mean increasing the number of police officers at schools — who, <a href="https://www.nytimes.com/2022/06/09/us/uvalde-shooting-police-response.html">as reporting continues to show</a>, did not prevent the shooting at Robb Elementary School in Uvalde, even as students called 911 from inside the school and parents tried to get in to help their children.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="W4YClv">
The framework also shows a strong focus on schools, though mass shootings can and do happen anywhere — grocery stores, concerts, and nightclubs included. “It’s frustrating to see people only reach out and care about things when it happens in school and to children,” González said in their <a href="https://www.theatlantic.com/politics/archive/2022/06/x-gonzalez-parkland-mass-shooting-gun-violence/661244/">Atlantic interview.</a> “They’re like, ‘This is especially heinous!’ Well, it’s equally heinous when it happens in a synagogue. It’s equally heinous when it happens in a Walmart. It’s equally heinous when it happens to one person on the street. And it’s all the fault of Congress.”
</p>
<h3 id="oEPmxY">
How can we tease meaningful change out of the legislative framework?
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Fed2rj">
There is meaning to be found in the proposal, Although legislation is still in the draft phase and it’s not clear at all whether the final bill could even pass the highly divided Senate, the aspects of the framework that does address firearms could be significant.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="hEeYaq">
For example, state crisis intervention orders are already enacted in some states and, thus far, “don’t represent Second Amendment problems,” according to Ruben. ‘‘There are two lines of constitutional attack here. One would be the Second Amendment, the other would be the Due Process Clause,” he said, explaining that the crisis intervention orders, which allow a civil court to remove firearms or ammunition from people determined to be a danger to themselves or others, “require an initial showing to get a temporary removal order, and then it becomes final only after a hearing, where whoever is petitioning to have the firearms removed has to establish that the person presents a danger to themselves or others — and that person can challenge that effort in court during a hearing.” Expanding crisis intervention orders, then, could prove to be a meaningful, if incremental, step in gun control policy, and one that can withstand constitutional challenges.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4ZSTLS">
Other elements of the framework, like closing the so-called “<a href="https://www.law.georgetown.edu/american-criminal-law-review/aclr-online/volume-55/closing-the-boyfriend-loophole-proposals-to-protect-dating-partners-from-gun-violence/">boyfriend loophole</a>,” could present big wins, too, according to Ruben. That loophole refers to the Lautenberg Amendment, which prevents some domestic violence offenders — but not all violent domestic partners — from owning firearms. Extending that provision to abusive domestic and dating partners who aren’t spouses could make massive inroads in preventing gun violence, especially violence against women. According to a 2020 study published in the <a href="http://jaapl.org/content/early/2020/02/05/JAAPL.003929-20">Journal of the American Academy of Psychiatry and the Law Online</a>, “when women are killed, they are more likely to be killed by an intimate partner than anyone else.” Research suggests a strong correlation between firearm use and intimate partner violence. Better definitions of domestic violence offenders would certainly serve to curb gun-related intimate partner homicides.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QE21ar">
“One thing I will be interested to see, this enhanced background check for under-21 gun buyers… I’ll be really interested to see how that looks,” Ruben said. “The whole idea of the juvenile delinquency system is, these aren’t criminal proceedings, these find young people delinquent, we have a whole different lingo. But this one could be interesting, because in response to the Buffalo and Uvalde shootings, one thing that was notable was that those young men followed the law. They lawfully purchased the gun they purchased, and they bought them at 18.” Extending the background check period for under-21 gun buyers would actually provide adequate time for the <a href="https://rollcall.com/2019/10/10/charleston-mass-murderer-got-his-gun-because-of-background-check-gaps-internal-report-shows/">background checks</a> to be completed, since the current statute provides a three-day window for background checks. If nothing is flagged on a purchaser’s record within that timeframe, even if the background check is incomplete, <a href="https://giffords.org/lawcenter/gun-laws/policy-areas/background-checks/background-check-procedures/">a dealer is allowed to complete the sale</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FjruaJ">
Despite the potential that the framework holds, there’s still the matter of finding 10 Republican senators who could provide a filibuster-proof majority and pass the resulting legislation, which is no small feat. Already, MAGA supporters in the House of Representatives are deriding the framework, falsely claiming that it impinges on Second Amendment rights and calling the Republican legislators working on it RINOs.
</p>
<div id="wL4t7n">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
MAGA reaction to today’s news of a bi-partisan compromise in the Senate for gun control bill. <a href="https://t.co/ZsnJ8gNM8Y">pic.twitter.com/ZsnJ8gNM8Y</a>
</p>
— Ron Filipkowski (<span class="citation" data-cites="RonFilipkowski">@RonFilipkowski</span>) <a href="https://twitter.com/RonFilipkowski/status/1536082129741815809?ref_src=twsrc%5Etfw">June 12, 2022</a>
</blockquote></div></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Mb7l4e">
The Senate also has limited time to draft and vote on the legislation before its two-week July recess — very little time, given the contentious nature of gun control legislation. But if it does happen, the House of Representatives — which <a href="https://apnews.com/article/congress-texas-buffalo-new-york-shootings-0d552cfe6c5a4fb8c83a151ea29d467f">already passed a broad gun control package</a> earlier in the week — <a href="https://www.washingtonpost.com/politics/2022/06/12/senate-gun-deal-framework/">will likely pass whatever is able to make it through the Senate</a>, marking some actual momentum to enact legislation that will curb gun violence and will save lives.
</p>
<ul>
<li><strong>The best $2,618 I ever spent: A second wedding ceremony</strong> -
<figure>
<img alt="An illustration of a wedding invitation atop its envelope." src="https://cdn.vox-cdn.com/thumbor/yjDB5rYLQzomQpo9kiVGnFM4PNs=/500x0:3500x2250/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/70968250/Wedding.0.jpg"/>
<figcaption>
I was fiercely independent, and didn’t have faith I could care for anyone else. But Antoinette always believed in me. | Dana Rodriguez for Vox
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Six months after I nearly destroyed our first $26,112 day.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8n5biw">
Four days after we walked down the aisle for the first time, my wife Antoinette and I cruised off on our honeymoon to Cozumel, Mexico. On our second night, we found ourselves sitting in a theater full of our fellow passengers as contestants on a knockoff version of the ’60s game show, <em>The Newlywed Game</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="meNBrA">
The first question was easy — “Where was your first date?”— but they devolved quickly: Which in-law would you least like to be stuck on a deserted island with? Which movie best describes your love life? What is your husband’s most annoying habit?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KHcCuG">
We got every question correct, and every answer was filled with resentment. Our first date was a 1930s diner outing at Quintessence, a Cap City landmark. We both deemed our love life to be akin to <em>Pee-wee’s Big Adventure</em>, and my wife offered three things she despised about me: how I wiped my nose with my finger, my nail munching, and how I was overall a neurotic nebbish.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iPELiL">
We were suffering from the fallout of the past year: everything leading to what would be our first wedding ceremony. I didn’t deal well with change, and a wedding changes everything. It changes your family structure, changes how to organize finances. I was fiercely independent, and I didn’t have faith I could care for anyone else. But Antoinette always believed in me, and, somehow, every time I struggled with moving forward in our relationship, and every time I struggled with moving forward in life, Antoinette pushed me, and together we got through.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JddSpp">
“Fill in the blank,” the Drew Carey-looking cruise director said to me. “The ugliest thing about my wife is ____.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CxSwsI">
“Her tones,” I said, straight-faced. The host froze up, devoid of one-liners. We won, obviously.
</p>
<hr class="p-entry-hr" id="NcatkG"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wFKEWk">
Antoinette and I met in April 2009, after the lead organizer of the mentoring program I volunteered for asked me to pick up the new mentor, a Brooklynite studying Africana studies and communications at SUNY Albany, speeding toward her bachelor’s in three years.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="co758N">
We cruised through the city in my blue Saturn as I fumbled over icebreakers: Where’re you from? What’re you studying?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="w2Oe8c">
Luckily for me, Antoinette was more skilled at the conversation thing. She dug through my CDs, pointing out that she also loved Maxwell and Amy Winehouse.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="onBwD4">
From then on, every week we drove around discussing race and religion and swapping book recommendations. I learned that, right before we met, Antoinette had left her ex-fiancé. To mark a new beginning, she pierced her nose and went in for the big chop, cutting off any chemically treated hair, and rocked an afro puff. I adored her positive energy, so when she mentioned she wanted to get her driver’s license, I volunteered my car for practice.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LyEaOM">
We spent afternoons circling parking lots and gently bumping cars while parallel parking. When she scored her license, I came up with more excuses to hang out. After six months of being friends, she dropped the bomb, asking me via text: “Do you like me?” My hands shaking, I typed “yes.”
</p>
<div class="c-float-right">
<aside id="Yliraw">
<q>I knew a life with Antoinette was what was best for me. I just feared it wasn’t best for her.</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2sFfrY">
Soon, I introduced her to my small, close-knit Ashkenazi Jewish family, and she welcomed me into her large but distant Nigerian and Jamaican crew. I loved how close she was to her mom, how she planned to have an intergenerational household. She appreciated how I was best friends/nearly twins with my little sister, how my big sister and her husband set my #couplegoals. Together we cooked salt fish latkes.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="g2QAKz">
When Antoinette and I met, I was 28 and three years sober. I had spent most of my early 20s dropping in and out of college, spending time behind the locked double doors of St. Peter’s Hospital detox unit, failing out of their rehab. In the first few years of my sobriety, I spent my days chilling on the stoop outside 12-step meetings on the corner of Lexington, working an entry-level respite position at a local social work agency.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sTdnu1">
I liked my life in early recovery. I liked the room I rented in a two-bedroom on Morris St. Liked making meetings whenever I wanted. Liked volunteering to make myself feel good. My life felt safe. But four years after we started dating, Antoinette was tired of my inertia. She wanted marriage, a house, and a family (with seven kids, she used to joke).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="RoVk8i">
As terrified of change as I was, I feared losing her more. I stalled for another year, but I finally popped the question over a bucket of seafood in a booth at our favorite Times Square eatery, Bubba Gump’s.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M8EUKv">
Then I talked her into delaying the ceremony another year.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BfM8cH">
I knew I loved and adored her, but I didn’t have faith in myself. I had never envisioned a future for me that involved anything more than hitting up meetings and remaining stagnant at the same social work agency. Starting a family felt unfathomable. During my hazy years, I stopped attempting to get sober because I figured I would just relapse. Once sober, I wouldn’t push myself to take any additional risks — whether it be a better job or a marriage — expecting that I’d mess everything up. Proposing was terrifying, but, beneath my distress, I knew a life with Antoinette was what was best for me. I just feared it wasn’t best for her.
</p>
<hr class="p-entry-hr" id="smmRIx"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="GKnyH7">
I remember reading a study that said <a href="https://www.theatlantic.com/health/archive/2014/10/the-divorce-proof-marriage/381401/">the more you spend on your wedding, the more likely it will end in divorce</a>. Every time Antoinette brought up ideas for venues, my mind spiraled. Neither of us made tons of money and neither was great at saving. To me, spending excessively on a wedding made no sense, but to Antoinette, money could always be made and was to be enjoyed. The tradition meant a lot to her so she wanted the perfect wedding ceremony, but, in truth, it probably meant more to me. A wedding made things absolute. I would either succeed at being a good partner forever or destroy her life. The more we spent, the more I felt the pressure mounting. Still, I pushed myself to brave forward with whatever Antoinette wished for.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yxkmeI">
To afford the wedding, I focused on our day-to-day bills — rent, car insurance, internet, groceries — while Antoinette saved for the ceremony. We quickly put a deposit down on the fourth floor of the New York State Museum, claiming Antoinette’s dream location. The setting included a sick view of the Empire State Plaza and Capitol building. It was the perfect Albany landmark for a romance that bloomed across its streets.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ezhn0D">
The wedding was scheduled for a Sunday because we kinda-sorta kept Shabbat, and I used the odd day as leverage to haggle down prices. We locked in Mallozzi’s, one of the capital’s ritziest caterers, as well as DJ Trumastr, Albany’s hottest DJ, who prepped a setlist consisting of Paul Simon, Lynxxx, and Beres Hammond, representing our diverse backgrounds. The affair came out to $26,112.86.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YBGAQ0">
To be clear, we didn’t pay it all ourselves. Her dad handled the photographer and the balance for the venue, and her mom took care of the honeymoon and wedding dress, and she financed transportation for nearly her entire extended family (after the wedding, my parents gifted us a $10,000 check, to start our life together — that promptly went toward debt). The more our family invested in our stock, the more I panicked it would all go belly up.
</p>
<hr class="p-entry-hr" id="wMN0kw"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sTfV8L">
Four months before our scheduled wedding date, my fears of failure turned catastrophic as my family fell into disarray.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fupPLI">
Just weeks before my youngest sister’s wedding — which I already struggled with because it felt like our relationship was changing — my brother-in-law walked out on my older sister. He had been my role model, my biggest male influence. He gave me my first beer, taught me all his comedy routines. I told myself that if my big sister’s marriage went sour, my relationship with Antoinette would, too.
</p>
<div>
<aside id="CnnTQr">
<q>We posed for pictures, smiling before the carousel, but the emotions were staged</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HhU8mK">
I was unable to send the wedding invites. Every time I postponed, Antoinette grew more frustrated, to the point where we were sleeping in separate rooms. I broke up with her, three times, assuring myself she’d be better off without me, but she continued to talk me into staying. Two months before the ceremony, I dropped the invites into the mailbox, but the stabbing thoughts intensified. I had dreams of her happy with someone else, starting a family with a guy who wasn’t as mentally ill as I was. I had nightmares of us getting married, having kids, then me turning into my brother-in-law, leaving the family I loved to suffer the repercussions. A week before the ceremony, I broke up with her for the final time, promising myself I wouldn’t budge.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1W6PyI">
Tears dampening her face, Antoinette smooshed her cheek into mine and whispered, “Just be with me for one day. Not all the future. Just a day.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="erZiDv">
At that moment, I decided to stay. To give it my best shot, just for that day. I tried to tell myself that I wasn’t my family, that I wasn’t the person I used to be. I decided I didn’t like myself at that moment, but I wanted to get better. I wanted to be the best person I could be, and the best person I could be was beside Antoinette, supporting her and celebrating her and growing with her.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gsOT3g">
The day of the wedding, Antoinette half-expected I wouldn’t show. Even though we did the I-dos, she despised me for what I put her through, and I was frustrated with her for not having empathy during my crash. We threw the greatest party most of our guests had ever been to — impressing even my Nigerian ambassador father-in-law — but every kiss was strained. We posed for pictures, smiling before the carousel, but the emotions were staged. When we cruised off on our <em>Newlywed Game</em>-knockoff honeymoon, we were barely speaking.
</p>
<hr class="p-entry-hr" id="SvEYur"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qcxTk2">
In the months that followed, we dedicated ourselves to couples therapy, determined to make our relationship work. We both realized that we struggled with communicating: Antoinette often shut down, while I turned overly emotional. We had to learn new ways to speak to each other. We focused on each other’s strengths, recognizing that we each brought something special to the table that the other lacked. I took responsibility for spiraling out of control, nearly ruining our wedding, and she worked to be empathetic to my anxiety. I realized how desperately I wanted her to attain her every dream and how blessed I was that she chose me to be her partner in achieving them; she believed in me, and I began to believe in me, too.
</p>
<div class="c-float-right">
<aside id="ZY4XEG">
<q>We weren’t trying to show off — we just wanted to feed friends and family yummy food and spin in circles of joy</q>
</aside>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="LRNCSY">
For over a year, Antoinette had been meeting with our rabbi, taking classes, attending shul, moving toward converting to Judaism. We had always planned to have a second, intimate religious wedding after she formally converted. And so six months after the first wedding, my wife dunked herself into the mikvah, a ritual bath, completing the process, and we held a small ceremony in our Albany temple, costing $2,618: enough to rent the social hall, hire a klezmer band, contract a videographer, borrow a chuppah, and buy a crap ton of lox, bagels, and kugel.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sQ38DW">
The first wedding, we were trying to impress people, but this second wedding, we weren’t trying to show off — we just wanted to feed friends and family yummy food and spin in circles of joy. We didn’t even send invites. Instead, we handed out flyers and plastered them online, keeping the ceremony open to anyone who wanted to join.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zZyVXa">
I took pride in planning and paying for the second ceremony myself. Though the event was much cheaper, I didn’t settle for anything. The food was on point. So were our outfits. It felt like victory that every dollar spent was my own — I was investing in our future.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S118m3">
Under the chuppah, I crunched the glass and we jumped the broom. When we leaped, we did it together. The community lifted us aloft in chairs, and, as we floated above the crowd, each grasping the napkin connecting us, I realized I could do it. I could handle life’s changes. I could grow. My wife had been with me when I was at my lowest. I knew I’d do the same for her. We’d survived one of our toughest hurdles, and I had faith we could get through more. I was ready. Ready to create a home, ready to start a family, with faith, with Antoinette.
</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India qualify for FIFAe Nations Series 2022</strong> - India defeated Korea Republic and Malaysia in the FIFAe Nations Series 2022 playoffs to seal their qualification</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Back home: Erling Haaland completes move to Man City from Borussia Dortmund</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Floyd Mayweather Jr. touched by Hall of Fame induction</strong> - Floyd Mayweather Jr. was inducted into the International Boxing Hall of Fame in a ceremony that included the past three classes</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Shadab gives Pakistan ODI series sweep against West Indies</strong> - The series win lifted Pakistan to No. 4 on the points table — immediately above West Indies — in the ICC Cricket World Cup Super League</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Shane Warne honoured posthumously, Ash Barty awarded in Queen's birthday list</strong> -</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Swapna Suresh moves Kerala High Court to quash criminal case</strong> - Revelation of statement in public not illegal, she contends</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Tension prevails at Gudatipally</strong> - Police force enter village in the wee hours</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sixty nine illegally constructed houses inside Manipur forest demolished</strong> - Senior officials of the district administration and Forest Department were present when the houses were demolished.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Scheme to reduce food wastage launched in Tiruvallur</strong> - Ma. Subramanian inaugurates ‘Food Festival 2022’ in the district</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Compensation paid to all, except a few: Husnabad RDO</strong> -</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ukraine war: Former British soldier Jordan Gatley killed in fighting</strong> - Jordan Gatley was killed as Ukrainian forces fought for control of Severodonetsk, his family said.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>French election: Left surge threatens Macron majority in France</strong> - A strong showing by a left-green alliance jeopardises the French president’s parliamentary majority.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Have a look inside Russia’s new ‘Tasty’ McDonald’s replacement</strong> - The new Russian brand is called “Vkusno i Tochka”, which translates to “Tasty and that’s it”.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Azerbaijan Grand Prix: Max Verstappen wins in Baku as Charles Leclerc retires</strong> - Max Verstappen wins the Azerbaijan Grand Prix and takes control of the World Championship after an engine failure on Charles Leclerc’s Ferrari.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia hands out passports in occupied Ukraine cities</strong> - The issuing of Russian passports in occupied Kherson and Melitopol is condemned by Kyiv.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Credentials for thousands of open source projects free for the taking—again!</strong> - Leak of credentials can be used in massive supply-chain attacks. - <a href="https://arstechnica.com/?p=1860268">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Starfield gameplay premiere resembles “No Man’s Skyrim,” leads Xbox showcase</strong> - <em>Forza Motorsport</em> stands out as a current-gen stunner. But what about today’s no-shows? - <a href="https://arstechnica.com/?p=1860390">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why can’t we remember being born or our first words?</strong> - What scientists know about “infantile amnesia.” - <a href="https://arstechnica.com/?p=1860244">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NASA’s plan to get Ingenuity through the Martian winter</strong> - NASA engineers are trying to overcome colder nights and frequent dust storms. - <a href="https://arstechnica.com/?p=1860133">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The weekend’s best deals: Apple Music subscriptions, Sony headphones, and more</strong> - Dealmaster also includes Sonos speakers, lots of video games, and the Google Chromecast. - <a href="https://arstechnica.com/?p=1860239">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>The wage gap isn’t real.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Men simply focus on getting the higher paying jobs like scientist, doctor, engineer. Meanwhile, women tend to go towards the lower paying jobs, like female scientist, female doctor and female engineer.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/LeBoi124"> /u/LeBoi124 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vb388z/the_wage_gap_isnt_real/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vb388z/the_wage_gap_isnt_real/">[comments]</a></span></p></li>
<li><strong>A man walks in a bar and sees a jar full of 100$ bills</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A man walks in a bar and sees a jar full of $100 bills, so he asks the bartender why there is so much money in the jar.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The bartender replies that it is a bet and you have to pay $100 to partecipate. The bet consists in three tests:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The first test: You see that man sitting back there? His name is Big Jim, he stands 6’5 feet tall (2 meters) and weighs 551 pounds (250 Kilograms), you have to knock him out.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The second test: If you pass the first test, you have to get out of the bar, where there’s Big Jim’s dog. You have to remove a tooth from it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The third test: If you pass the second test, you have to go on the second floor where there’s Big Jim’s mom, an 85 years old woman who never reached an orgasm. You have to fuck her like you have never done before.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
If you pass the three tests all the money in the jar will be yours, but I warn you, no one has ever managed to win the bet.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
At this point the man gives up and orders the bartender to give him some whisky. After “a few drinks”, the man, completely drunk, says: “fuck you, I will take the bet!” and puts $100 on the bar counter.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Staggering, he walks over to Big Jim and kicks him in the balls, knocking him out.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He remembers the second test, gets out of the bar and face Big Jim’s dog. At first the dog started to growl, then it starts to howl, and then silence…
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A few seconds later the man returns to the bar and asks the bartender:
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
“AND NOW WHERE IS THE OLD WOMAN WHOSE TOOTH I HAVE TO REMOVE?”
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/XChri"> /u/XChri </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vang2g/a_man_walks_in_a_bar_and_sees_a_jar_full_of_100/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vang2g/a_man_walks_in_a_bar_and_sees_a_jar_full_of_100/">[comments]</a></span></p></li>
<li><strong>A Hunter</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A man goes hunting and runs into a bear. He takes dead aim and fires. When the smoke clears, he sees no bear. The bear taps him on the shoulder and says: bend over or I eat you. The next year, the hunter brings a bear gun, sees the very same bear, takes dead aim and fires. When the smoke clears, the hunter is in shock to find no bear. Tap on shoulder: bend over or I eat you. The next year, the hunter arrives with a bazooka. He sees the bear, takes dead aim and fires. Rocks and earth reign down, the smoke clears and no bear. The bear taps him on the shoulder and says: you don’t come here for the hunting do you?
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Boxwood50"> /u/Boxwood50 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vax2s2/a_hunter/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vax2s2/a_hunter/">[comments]</a></span></p></li>
<li><strong>I asked my boss for a raise.</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He said what for?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I told him 3 different companies are after me. He asked which ones?
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I said: Gas, Water, and Electric.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/drewfussss"> /u/drewfussss </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vam29r/i_asked_my_boss_for_a_raise/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vam29r/i_asked_my_boss_for_a_raise/">[comments]</a></span></p></li>
<li><strong>From my eight year old daughter: What is the strongest bird?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
A crane.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/hadrian217"> /u/hadrian217 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/vawnbs/from_my_eight_year_old_daughter_what_is_the/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/vawnbs/from_my_eight_year_old_daughter_what_is_the/">[comments]</a></span></p></li>
</ul>
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