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+ + + ++Host population demographics and patterns of host-to-host interactions are important drivers of heterogeneity in infectious disease transmission. To improve our understanding of how population structures and changes therein influence disease transmission dynamics at the individual and population level, we model a dynamic age- and household-structured population using longitudinal microdata drawn from Belgian census and population registers. At different points in time, we simulate the spread of a close-contact infectious disease and vary the age profiles of infectiousness and susceptibility to reflect specific infections (e.g. influenza and SARS-CoV-2) using a two-level mixing model, which distinguishes between exposure to infection in the household and exposure in the community. We find a strong relationship between age and household structures, which, in combination with social mixing patterns and epidemiological parameters, shape the spread of an emerging infection. Disease transmission in the adult population in particular is explained by differential household compositions and not just household size. Moreover, we highlight how demographic processes alter population structures in an ageing population and how these in turn affect disease transmission dynamics across population groups. +
++A coordinated testing policy is an essential tool for responding to emerging epidemics, as was seen with COVID-19. However, it is very difficult to agree on the best policy when there are multiple conflicting objectives. A key objective is minimising cost, which is why pooled testing (a method that involves pooling samples taken from multiple individuals and analysing this with a single diagnostic test) has been suggested. In this paper, we present results from an extensive and realistic simulation study comparing testing policies based on individually testing subjects with symptoms (a policy resembling the UK strategy at the start of the COVID-19 pandemic), individually testing subjects at random or pools of subjects randomly combined and tested. To compare these testing methods, a dynamic model compromised of a relationship network and an extended SEIR model is used. In contrast to most existing literature, testing capacity is considered as fixed and limited rather than unbounded. This paper then explores the impact of the proportion of symptomatic infections on the expected performance of testing policies. Only for less than 50% of infections being symptomatic does pooled testing outperform symptomatic testing in terms of metrics such as total infections and length of epidemic. Additionally, we present the novel feature for testing of non-compliance and perform a sensitivity analysis for different compliance assumptions. Our results suggest for the pooled testing scheme to be superior to testing symptomatic people individually, only a small proportion of the population (>2%) needs to not comply with the testing procedure. +
++Rapid, simple, and low-cost diagnostic technologies are crucial tools for combatting infectious disease. Here, we describe a class of aptamer-based RNA switches called aptaswitches that recognize specific target nucleic acid molecules and respond by initiating folding of a reporter aptamer. Aptaswitches can detect virtually any sequence and provide a fast and intense fluorescent readout, generating signals in as little as 5 minutes and enabling detection by eye with minimal equipment. We demonstrate that aptaswitches can be used to regulate folding of six different fluorescent aptamer/fluorogen pairs, providing a general means of controlling aptamer activity and an array of different reporter colors for multiplexing. By coupling isothermal amplification reactions with aptaswitches, we reach sensitivities down to 1 RNA copy/microL in one-pot reactions. Application of multiplexed one-pot reactions against RNA extracted from clinical saliva samples yields an overall accuracy of 96.67% for detection of SARS-CoV-2 in 30 minutes. Aptaswitches are thus versatile tools for nucleic acid detection that can be readily integrated into rapid diagnostic assays. +
++The systemic inflammatory response seen in patients with severe COVID-19 shares many similarities with the changes observed in hemophagocytic lymphohistiocytosis (HLH); a disease characterized by excessive immune activation. Many patients with severe COVID qualify for a diagnosis of HLH. Etoposide, an inhibitor of topoisomerase II is used to control inflammation in HLH. This randomized, open-label, single center phase II trial attempted to determine whether etoposide can be used to blunt the inflammatory response in severe COVID. This trial was closed early after eight patients were randomized. This underpowered trial did not meet its primary endpoint of improvement in pulmonary status by two categories on an 8 point ordinal scale of respiratory function. There were not significant differences in secondary outcomes including overall survival at 30 days, cumulative incidence of grade 2 through 4 adverse events during hospitalization, duration of hospitalization, duration of ventilation and improvement in oxygenation or paO2/FIO2 ratio or improvement in inflammatory markers associated with cytokine storm. A high rate of grade 3 myelosuppression was noted in this critically ill population despite dose reduction, a toxicity which will limit future attempts to explore the utility of etoposide for virally-driven cytokine storm or HLH. +
++Objectives. To assess the association of Long COVID with housing insecurity in the United States. Methods. To compare the prevalence of 3 binary indicators of housing insecurity between people with Long COVID (symptoms > 3 months) and COVID-19 survivors who don9t report long-term symptoms, we used survey-weighted regression models on 203,807 responses from the Household Pulse Survey, a representative survey of US households collected September 2022 - April 2023. Among people with Long COVID, we assessed whether functional impairment, current COVID-19 related symptoms, and symptom impact on day-to-day life were associated with a higher prevalence of housing insecurity. Results. During the study period, 54,446 (27.2%) respondents with COVID-19 experienced symptoms lasting 3 months or longer, representing an estimated 27 million US adults. People with Long COVID were nearly twice as likely to experience significant difficulty with household expenses (Prevalence ratio [PR] 1.85, 95% CI 1.74-1.96), be behind on housing payments (PR 1.76, 95% CI 1.57-1.99), and face likely eviction or foreclosure (PR 2.12, 95% CI 1.58-2.86). Functional limitation and current symptoms which impact day-to-day life were associated with higher prevalence of housing insecurity. Conclusions. Compared with COVID-19 survivors who don9t experience long-term symptoms, people with Long COVID are more likely to report indicators housing insecurity, particularly those with functional limitations and long-term COVID-19 related symptoms impacting day-to-day life. Policies are needed to support people living with chronic illnesses following SARS-CoV-2 infection. +
+Extracorporeal Photopheresis as a Possible Therapeutic Approach to Adults With Severe and Critical COVID-19 - Condition: COVID-19
Intervention: Procedure: Extracorporeal photopheresis
Sponsor: Del-Pest Central Hospital - National Institute of Hematology and Infectious Diseases
Recruiting
A Clinical Trial on Booster Immunization of Two COVID-19 Vaccines Constructed From Different Technical Routes - Condition: COVID-19
Interventions: Biological: Prototype and Omicron BA.4/5 Bivalent Recombinant COVID-19 Vaccine(Adenovirus Type 5 Vector) For Inhalation; Biological: Bivalent COVID-19 mRNA Vaccine; Biological: Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) For Inhalation
Sponsors: Zhongnan Hospital; Institute of Biotechnology, Academy of Military Medical Sciences, PLA of China
Recruiting
Evaluation of Safety, Tolerability, Reactogenicity, Immunogenicity of Baiya SARS-CoV-2 Vax 2 as a Booster for COVID-19 - Conditions: COVID-19 Vaccine; COVID-19
Interventions: Biological: 50 μg Baiya SARS-CoV-2 Vax 2; Other: Placebo
Sponsor: Baiya Phytopharm Co., Ltd.
Not yet recruiting
Safety Study of COVID19 Vaccine on the Market - Condition: COVID-19
Intervention: Biological: Recombinant new coronavirus vaccine (CHO cell)
Sponsors: Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.; Hunan Provincial Center for Disease Control and Prevention; Guizhou Center for Disease Control and Prevention; Hainan Center for Disease Control & Prevention
Recruiting
ACTIV-6: COVID-19 Study of Repurposed Medications - Arm B (Fluvoxamine) - Condition: Covid19
Interventions: Drug: Fluvoxamine; Other: Placebo
Sponsors: Susanna Naggie, MD; National Center for Advancing Translational Sciences (NCATS); Vanderbilt University Medical Center
Completed
Physiotherapy in Mutated COVID-19 Patients - Condition: COVID-19 Pandemic
Intervention: Behavioral: Physiotherapy
Sponsor: Giresun University
Completed
Evaluation of Home Use COVID-19 Frequent Antigen Testing and Data Reporting - Condition: COVID-19 Respiratory Infection
Intervention: Diagnostic Test: SARS CoV-2 antigen tests
Sponsors: IDX20 Inc; National Institute on Minority Health and Health Disparities (NIMHD)
Recruiting
Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19 - Conditions: SARS-CoV Infection; COVID-19
Interventions: Drug: Mitoquinone/mitoquinol mesylate; Other: Placebo
Sponsor: University of Texas Southwestern Medical Center
Not yet recruiting
Pycnogenol® in Post-COVID-19 Condition - Conditions: Post COVID-19 Condition; Long COVID
Interventions: Drug: Pycnogenol®; Drug: Placebo
Sponsor: University of Zurich
Not yet recruiting
To Explore the Regulatory Effect of Combined Capsule FMT on the Levels of Inflammatory Factors in Peripheral Blood of Patients With COVID-19 During Treatment. - Conditions: Fecal Microbiota Transplantation; COVID-19 Infection
Intervention: Procedure: Fecal microbiota transplantation
Sponsor: Shanghai 10th People’s Hospital
Completed
Efficacy of Bailing Capsule on Pulmonary Fibrosis After COVID-19 - Conditions: Pulmonary Fibrosis; COVID-19 Pneumonia
Intervention: Drug: Bailing capsule
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Not yet recruiting
Evaluating Emetine for Viral Outbreaks (EVOLVE) - Condition: COVID-19
Interventions: Drug: Emetine Hydrochloride; Drug: Placebo
Sponsors: Johns Hopkins University; Nepal Health Research Council; Bharatpur Hospital Chitwan; Stony Brook University; Rutgers University
Not yet recruiting
Phase 3 Study of Novavax Vaccine(s) as Booster Dose After mRNA Vaccines - Condition: COVID-19
Interventions: Biological: NVX-CoV2373; Biological: SARS-CoV-2 rS antigen/Matrix-M Adjuvant
Sponsor: Novavax
Active, not recruiting
A Study to Learn About How Loss of Liver Function Affects the Blood Levels of the Study Medicine Called PF-07817883. - Condition: COVID-19
Intervention: Drug: PF-07817883
Sponsor: Pfizer
Not yet recruiting
Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19) - Conditions: Long COVID; Post-Acute Sequela of COVID-19; Post-Acute COVID-19
Interventions: Drug: AER002; Other: Placebo
Sponsors: Michael Peluso, MD; Aerium Therapeutics
Not yet recruiting
Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase - Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (M^(pro), 3CL^(pro)) and papain-like protease (PL^(pro)) are responsible for viral polyprotein cleavage-a process crucial for viral survival and replication. Recently it was shown that 2-phenylbenzisoselenazol-3(2H)-one (ebselen), an organoselenium anti-inflammatory small-molecule drug, is a potent, covalent inhibitor of both the proteases and its potency was evaluated in…
One Week of Oral Camostat Versus Placebo in Non-Hospitalized Adults with Mild-to-Moderate COVID-19: A Randomized Controlled Phase 2 Trial - CONCLUSIONS: In a phase 2 study of non-hospitalized adults with mild-to-moderate COVID-19, oral camostat did not accelerate viral clearance nor time to symptom improvement, nor reduce hospitalizations or deaths. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT04518410.).
A clinical pharmacokinetic drug-drug interaction study between dextromethorphan and emvododstat, a potent anti-SARS-CoV-2 dihydroorotate dehydrogenase inhibitor - CONCLUSION: Emvododstat appears to be a strong CYP2D6 inhibitor. No drug-related treatment emergent adverse effects (TEAEs) were considered to be severe or serious.
The PRMT5/WDR77 complex restricts hepatitis E virus replication - Hepatitis E virus (HEV) is one of the main pathogenic agents of acute hepatitis in the world. The mechanism of HEV replication, especially host factors governing HEV replication is still not clear. Here, using HEV ORF1 trans-complementation cell culture system and HEV replicon system, combining with stable isotope labelling with amino acids in cell culture (SILAC) and mass spectrometry (MS), we aimed to identify the host factors regulating HEV replication. We identified a diversity of host…
Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors - Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the clearance of pathogens. However, pyroptosis is a double-edged sword. Numerous studies have revealed the relationship between abnormal GSDMD activation and various inflammatory diseases, including sepsis, coronavirus disease 2019 (COVID-19),…
Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection - Coronavirus disease 2019 (COVID-19) has had devastating effects worldwide, with particularly high morbidity and mortality in outbreaks on residential care facilities. Amantadine, originally licensed as an antiviral agent for therapy and prophylaxis against influenza A virus, has beneficial effects on patients with Parkinson’s disease and is used for treatment of Parkinson’s disease, multiple sclerosis, acquired brain injury, and various other neurological disorders. Recent observational data…
In silico evidence implicating novel mechanisms of Prunella vulgaris L. as a potential botanical drug against COVID-19-associated acute kidney injury - COVID-19-associated acute kidney injury (COVID-19 AKI) is an independent risk factor for in-hospital mortality and has the potential to progress to chronic kidney disease. Prunella vulgaris L., a traditional Chinese herb that has been used for the treatment of a variety of kidney diseases for centuries, could have the potential to treat this complication. In this study, we studied the potential protective role of Prunella vulgaris in COVID-19 AKI and explored its specific mechanisms applied by…
Analyzing immune responses to varied mRNA and protein vaccine sequences - In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA (mRNA), and protein subunit, have been developed against SARS-CoV-2. This has unintentionally created a unique scenario where heterologous prime-boost vaccination against a single virus has been administered to a large human population. Here, we aimed to analyze whether the immunization order of vaccine types influences the efficacy of heterologous prime-boost vaccination,…
Recent topics in the pathophysiology and treatment of immune thrombocytopenic purpura - Increased and impaired platelet productions via immunological abnormalities are the main pathophysiological mechanisms of primary immune thrombocytopenia (ITP). Recent studies have revealed that platelet removal from circulation involves not only Fc receptor-mediated phagocytosis of immunoglobulin G autoantibodies-bound platelets but also complement-dependent mechanism and platelet glycoprotein desialylation. Understanding the molecular mechanism of ITP pathophysiology has helped develop many…
Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial - BACKGROUND: Activation of the triggering receptor expressed on myeloid cells-1 (TREM-1) pathway is associated with septic shock outcomes. Data suggest that modulation of this pathway in patients with activated TREM-1 might improve survival. Soluble TREM-1 (sTREM-1), a potential mechanism-based biomarker, might facilitate enrichment of patient selection in clinical trials of nangibotide, a TREM-1 modulator. In this phase 2b trial, we aimed to confirm the hypothesis that TREM1 inhibition might…
Isolation of Anti-SARS-CoV-2 Natural Products Extracted from Mentha canadensis and the Semi-synthesis of Antiviral Derivatives - Traditional herbal medicine offers opportunities to discover novel therapeutics against SARS-CoV-2 mutation. The dried aerial part of mint (Mentha canadensis L.) was chosen for bioactivity-guided extraction. Seven constituents were isolated and characterized by nuclear magnetic resonance (NMR) and mass spectrometry (MS). Syringic acid and methyl rosmarinate were evaluated in drug combination treatment. Ten amide derivatives of methyl rosmarinate were synthesized, and the dodecyl (13) and…
Computational design of medicinal compounds to inhibit RBD-hACE2 interaction in the Omicron variant: unveiling a vulnerable target site - The COVID-19 pandemic, caused by SARS-CoV-2, has globally affected both human health and economy. Several variants with a high potential for reinfection and the ability to evade immunity were detected shortly after the initial reported case of COVID-19. A total of 30 mutations in the spike protein (S) have been reported in the SARS-CoV-2 (BA.2) variant in India and South Africa, while half of these mutations are in the receptor-binding domain and have spread rapidly throughout the world. Drug…
In silico screening, ADMET analysis and MD simulations of phytochemicals of Onosma bracteata Wall. as SARS CoV-2 inhibitors - Being attracted with their cardiotonic, antidiabetic, cough relieving activity, treatment of fever, absorbent, anti-asthmatic, etc. activities reported in ancient Ayurvedic literature, phytochemicals of Onosma bracteata wall should be evaluated for their activity against SARS-CoV-2 virus. The main objective of this study is to identify a hit molecule for the inhibition of entry, replication, and protein synthesis of SARS CoV-2 virus into the host. To achieve given objective, computational…
In silico Antivirus Repurposing and its Modification to Organoselenium Compounds as SARS-CoV-2 Spike Inhibitors - <b>Background and Objective:</b> The COVID-19, which has been circulating since late 2019, is caused by SARS-CoV-2. Because of its high infectivity, this virus has spread widely throughout the world. Spike glycoprotein is one of the proteins found in SARS-CoV-2. Spike glycoproteins directly affect infection by forming ACE-2 receptors on host cells. Inhibiting glycoprotein spikes could be one method of treating COVID-19. In this study, the antivirus marketed as a database will be…
PACT inhibits the replication of SARS-CoV-2 through the blockage of GSK-3β-N-nsp3 cascade - The protein activator of protein kinase R (PKR) (PACT) has been shown to play a crucial role in stimulating the host antiviral response through the activation of PKR, retinoic acid-inducible gene I, and melanoma differentiation-associated protein 5. Whether PACT can inhibit viral replication independent of known mechanisms is still unrevealed. In this study, we show that, like many viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks GSK-3β to facilitate its replication….
What if We’re Thinking About Inflation All Wrong? - Isabella Weber’s heterodox ideas about government price controls are transforming policy in the United States and across Europe. - link
What Does the Debt-Ceiling Agreement Say About the U.S. Political System? - The bipartisan deal showed that the government is still capable of avoiding a self-inflicted disaster, but a credit-ratings agency warns it is suffering from slow rot. - link
The Irrational Exuberance of a Non-Catastrophe - The bipartisan debt deal was a win for both Biden and McCarthy, but it might not have been the breakthrough Washington was waiting for. - link
What I Learned at My Audience with the Pope - Addressing the group, Francis spoke about the role of the imagination in the life of Catholicism. - link
Is It Possible to Be Both Moderate and Anti-Woke? - A small nonprofit launched by the journalist Bari Weiss devolves into tribalism. - link
+Countries are negotiating a new global treaty to drastically reduce the plastic waste that has been poisoning the world. +
++Plastic recycling doesn’t work, no matter how diligently you wash out your peanut butter container. Only about 15 percent of plastic waste is collected for recycling worldwide, and of that, about half ends up discarded. That means just 9 percent of plastic waste is recycled. +
++The rest — some 91 percent of all plastic waste — ends up in landfills, incinerators, or as trash in the environment. One report estimated that 11 million metric tons of plastic trash leaked into the ocean in 2016, and that number could triple by 2040 as the global population rises and lower-income countries develop. Plastic is now simply everywhere: at the deepest depths of the ocean, on the tallest mountains, in hundreds of species of wildlife, and even in human placentas. +
+ ++It’s hard to imagine meaningful solutions to a problem of such epic proportions. Campaigns to ban things like plastic straws almost seem like a joke when compared to the staggering amounts of waste produced by everything else we use — including the plastic cups those straws go in. +
++Now, however, there might actually be a reason to feel hopeful. Late last year, world leaders, scientists, and advocates started working on a global, legally binding treaty under the United Nations to end plastic waste. The second round of negotiations concluded last week in Paris with a plan to produce an initial draft of the deal. +
++This treaty could be huge. Although it will take months of negotiating for any of the details to become clear, the agreement — set to be finalized by the end of 2024 — will require countries to do far more than just fix their recycling systems. Negotiators will discuss a menu of options including a cap on overall plastic production, bans on certain materials and products including many single-use plastics, and incentives to grow an industry around reusable items. This treaty could literally transform entire chunks of the global economy. +
++As with any global deal, an ambitious agreement will face several roadblocks, some of which have already appeared. Certain countries, such as Saudi Arabia and the US, for example, are pushing for voluntary terms that would allow them to continue investing in their petrochemical industries (plastic is a petrochemical). +
++Then again, the fact that global talks are happening at all is in itself a big deal and reveals a shift in the politics around waste. “There’s a true willingness to tackle this problem,” said Erin Simon, vice president and head of plastic waste at the World Wildlife Fund, a large environmental group. “We’ve never seen so much progress.” +
++Here’s what a global plastic treaty could do, and why anti-waste advocates are so hopeful. +
+ ++Even if recycling weren’t such a failure, it wouldn’t put an end to plastic waste. Many items can’t be — or are not meant to be — recycled. +
++There’s no real way to fix the plastic problem without simply producing less of it, said Nicky Davies, executive director of the Plastic Solutions Fund, a group that funds projects to end plastic pollution. “The first thing we need to do is turn off the tap,” Davies said. +
++That’s why this treaty is so significant: By conception, the agreement is meant to focus on the design and production of plastics, not just on what happens to plastic items after we use them. In other words, the treaty targets the full life cycle of plastics. +
++What does that mean in practice? The agreement could, for example, include an overall cap on plastic. This would be a global target for reducing the production of new, virgin plastic (which has no recycled content). +
++Such a target could mandate that, by a certain year, total annual plastic production cannot exceed the amount of plastic produced in some baseline year. It’d be kind of like targets to slash fossil fuel production in order to curb climate change — but for plastic polymers. +
++Regardless of whether or not the treaty includes an explicit limit on plastic production, it will almost certainly contain bans or restrictions on some materials. +
++Certain chemicals used in plastics are especially problematic and could be targeted by bans. Some flame retardants, for example, are linked to cancers and endocrine disruption; they can also make plastics hard to recycle. A number of other additives and materials are similarly dangerous to humans or ecosystems, or they make recycling difficult, such as polyvinyl chloride (PVC) and various kinds of PFAS (the so-called forever chemicals). +
++The treaty may also ban or restrict a whole bunch of common, problematic products — namely, packaging and other single-use items, such as cups and cutlery. +
++These are an enormous part of the plastic problem, said Carroll Muffett, president and CEO of the Center for International Environmental Law, an environmental advocacy group. Roughly 40 percent of all plastic waste comes from packaging alone, and nearly two-thirds of it is from plastics that have a lifespan of fewer than five years, according to the Organisation for Economic Co-operation and Development. +
++“These are materials that come into people’s lives that are often unnoticed, and they have useful lives measured in minutes or moments or at best months,” Muffett told Vox. +
+ ++The most immediate bans or restrictions on single-use plastics, researchers say, should apply to products that are most likely to leak into the environment and cause harm and yet are relatively unnecessary. These include takeaway containers, chip bags, balloons, cotton swabs, disposable e-cigarettes, and tea bags. (A number of environmental organizations including WWF have lists of products that the treaty should prioritize.) +
++Speaking of unnecessary: The treaty may also restrict the use of certain microplastics. These are plastic pieces that are under 5 millimeters in length, which are either deliberately put in some products like face wash or are emitted unintentionally by things like car tires and clothing. Scientists have found them everywhere they look including in our blood and lungs, water bottles, and Antarctic snow. +
++Restricting these sorts of plastics isn’t a far-fetched idea. Several US states already ban some plastic bags, including New York and California. The US, Canada, the UK, and other countries, meanwhile, prohibit companies from selling shower gels and many other personal care products with plastic “microbeads” in them. And the EU — home to some of the world’s strictest plastic regulations — prohibits a wide number of single-use items from entering the market, including plastic cutlery and straws. +
++Yet these bans are not global, they’re not always enforced, and they don’t go far enough, experts say. That’s where the treaty could help. +
++Plastic is widespread for a few obvious reasons. It’s lightweight, durable, and easily shaped, making it useful for a large number of applications. Plastic is also incredibly cheap (even if government subsidies help offset some of the costs). +
++Should countries try to phase out single-use plastics, whether by a treaty or not, a key question is: What will replace it? In some cases, other materials like paper might be appropriate, although, of course, they can produce waste as well. +
++A more sustainable solution, Davies said, is to build out what she calls the reuse economy: a system in which many single-use items, like plastic cups, are replaced by containers that are used over and over again. +
++This model offers clear value where consumers buy and eat food in the same place, such as food courts, movie theaters, or music festivals. In a reuse economy, vendors would give customers a reusable cup, which they would then place in a bin before leaving the venue, not unlike how you return trays at some food courts. There’d be central facilities on site to clean the cups and make them available to the next customer. (That means dishwashing would have to become more widespread.) +
+ ++Transforming some other parts of the economy is more challenging, including the food delivery industry. Consider, however, that restaurants often use the same kinds of plastic food containers across large cities like New York. Imagine if those containers were meant to be truly reusable; instead of throwing them out or recycling them, consumers could return them (via some kind of bin, for example) to a central system that cleans the containers and restocks them at restaurants. +
++Obviously, this would require major investments in infrastructure by governments, private funders, and companies — not to mention some changes in behavior among consumers — but there are plenty of examples of these sorts of reuse systems already working successfully. They’ve been around for decades. In Europe and parts of Africa, Asia, and Latin America, restaurants and other retailers commonly sell beer and soda in refillable glass containers. Customers will typically get a small deposit back when they return those items. (An organization called Upstream maintains a list of reuse policies in the US and abroad.) +
++The treaty could help fuel this approach by mandating global targets related to reusing containers, some of which already exist at a country level (in France and elsewhere). For example, it could set a minimum percentage of drinks that must be sold in reusable containers. The treaty could also help set standards for what a good reusable system looks like and define what “reuse” actually means — considering that many plastic bags and other disposable items say they’re “reusable” even though most of us throw them out. +
++Davies says the reuse economy is essential to fixing the plastic problem — as essential as renewable energy is for curbing climate change. “We actually need to build the reuse economy in the same way as we have built the renewable energy economy,” Davies said. +
++The treaty won’t spell the end of recycling. Plenty of plastics aren’t easily cleaned or reused by other people, such as toothbrushes or plastics used in hospitals, so countries will still need recycling — but it requires major improvements. +
++Some cities and countries lack sufficient, conveniently located recycling bins or facilities to process plastic. Even where that infrastructure does exist, recycling runs into all kinds of problems. Plastics in a bin of recyclables typically contain a slew of polymers, dyes, and other chemicals that don’t necessarily mix well together or, when combined, form low-quality plastic, according to a report by the Pew Charitable Trusts, a research organization. Some of those chemicals can also make the recycling process itself unsafe for waste workers, Davies said. +
++“Today’s plastic recycling system is failing us,” authors of the Pew report wrote. +
++Beyond eliminating harmful chemicals in plastics, a key solution is to encourage or mandate that companies design for recycling from the beginning. That means phasing out dyes and other additives that make recycled plastic worth less, using fewer types of polymers that can contaminate recycling streams, and so on. Better labeling is important, too: You shouldn’t have to spend time Googling to figure out how to recycle something. +
++To encourage recycling, cities, and countries can also build out what are called “deposit return systems,” or DRS. In these schemes, customers pay a deposit when they buy a drink in a to-go bottle and get it back if they return the container (you may have seen these return machines by the entrance of some grocery stores). The treaty could mandate that countries require DRS for certain kinds of plastic containers. +
+ ++The treaty could also set a minimum percentage for the amount of recycled plastic in a given product. That would make recycled plastic more valuable and, in turn, encourage more recycling. Again, such targets are not unprecedented: The EU requires that, by 2025, PET plastic drink bottles are made with at least 25 percent recycled plastic. +
++(Treaty negotiators will consider a wide range of other ideas, such as eliminating subsidies for fossil fuels, setting standards for landfilling plastic, including those pertaining to the health of workers, and weeding out misleading claims about compostable or biodegradable plastics.) +
++Treaty negotiations have only just begun, yet some issues are already a source of tension. Perhaps the biggest one is whether targets under the treaty should be globally mandated — and apply to all countries — or voluntary and set by each nation individually. +
++A group of countries including all members of the EU, Japan, and Chile, known as the high ambition coalition, is pushing for global targets, whereas the US, Saudi Arabia, and other big plastic-producing nations are advocating for national voluntary targets. (Those voluntary targets would be similar to those under the 2015 Paris climate agreement, which set the goal of limiting global warming to 1.5 degrees Celsius to combat climate change.) +
++“The number one thing I want is global rules,” said Simon of WWF. “Plastic pollution is so integrated into all of our lives, and through these massive world markets. If we continue to address it in a fragmented way, we will never be successful.” +
+ ++A number of other core issues will likely divide countries along similar lines, such as whether the treaty should cap virgin plastic production and what specific materials it should ban. Generally, major oil-producing nations and other petrochemical interests, such as chemical companies, like to talk up the benefits of recycling instead of taking steps to curb plastic production. +
++Funding will almost certainly be a divisive issue, as well. There’s a common tension during negotiations for global environmental treaties between wealthy and poor nations. In this case, lower-income countries are likely to argue that they should pay less — or be paid — to implement the treaty because they’ve contributed relatively little to the problem of plastic waste (and in some cases suffer most from it). +
++Delegates from 175 countries finished up the last round of negotiations in Paris with a clear objective: To develop a draft of the plastic treaty before November, when they’ll meet again, in Nairobi, Kenya, for round three. The idea is to discuss the terms of the treaty in detail then, using the text (which they call a “zero draft”) as a starting point. +
++While UN treaty processes are often confusing and bogged down by bureaucracy, they’re one of our best defenses against global crises. And plastic pollution is indeed a global crisis. It’s everywhere — in our forests, our mountains, our oceans, our wildlife, our bodies, our children’s bodies. At least 85 percent of all marine waste is plastic. Hundreds of chemicals in plastics pose potential risks to human health. +
++It remains unclear whether negotiators will be able to craft an ambitious treaty. Then there will be questions about implementation. But the good news is that something similar has been done before, albeit on a smaller scale. +
++In 1987, nearly 200 countries agreed to a global deal called the Montreal Protocol designed to phase out chemicals called CFCs that were found in all sorts of products, from aerosol cans to refrigerators, which had put a hole in Earth’s ozone layer. The treaty worked. Today, 99 percent of ozone-destroying chemicals have been phased out and the ozone hole is almost fully repaired. +
++While the plastic problem is much bigger, global rules to phase out harmful materials can work. “This has been done before,” Muffett said. If world leaders take the problem of plastic pollution seriously, he said, “fundamental transformation is very, very possible.” +
+Did Russia do it? +
++A large dam on the Dnipro River, in southern Ukraine, has been destroyed, leading to major flooding and putting thousands at risk of another catastrophe along the war’s front lines. +
++Right now, both Ukraine and Russia are accusing the other of attacking the Nova Kakhovka dam and hydroelectric power plant, which sits about 20 miles from the city of Kherson. +
++Ukraine blamed Russian “terrorists” for the explosion. “This is just one Russian act of terrorism,” Ukrainian President Volodymyr Zelenskyy wrote on Telegram. “This is just one Russian war crime. Now Russia is guilty of brutal ecocide. Any comments are superfluous.” +
++Russia, meanwhile, accused Ukraine of staging an attack to cut off water to the Crimean peninsula and to distract from the start of its counteroffensive, which may finally be underway. “Apparently, this sabotage is also connected with the fact that, having started large-scale offensive actions two days ago, now the Ukrainian armed forces are not achieving their goals — these offensive actions are faltering,” said Kremlin spokesperson Dmitry Peskov. +
+++Satellite images from before and after the destruction of the Kakhovka dam in southern Ukraine.https://t.co/w4wIJdhX1X
+— NBC News (@NBCNews) June 6, 2023 +
: Planet Labs pic.twitter.com/sAHtxwaG0L +
+US and Western officials have also not made any definitive assessments yet, though most are leaning toward Russia as the likely suspect, especially given its history of targeting Ukrainian energy and civilian infrastructure intended to create humanitarian emergencies. Of course, Western leaders have been wrong before in attributing attacks to Russia, as with the sabotage of the Nord Stream pipeline, which is why Western and NATO officials have not drawn firm conclusions. +
++Russia also has controlled the Nova Kakhovka dam since the early days of the war, which means, even if this was somehow an accident or unintentional explosion, it’s happening on its watch. Ukraine has also been warning since last year that Russia had mined the dam, and previously claimed Moscow had plans to destroy it ahead of its retreat from Kherson last fall. +
++And the dam explosion is happening against an uptick in Ukrainian attacks that have some Western officials believing Ukraine’s counteroffensive is underway. Though a lot of that fighting is currently happening in the east, away from the dam, a disaster could tie up Ukrainian resources and potentially make it more difficult for troops to advance in the future. +
+ ++The Kakhovka reservoir and power plant was built in the Soviet era in 1956. The reservoir has about the same volume of water as Utah’s Great Salt Lake. The levels in the Dnipro River had been at record-high water levels in recent days, so the possibility of mismanagement or some sort of accident can’t be ruled out, although that is harder to square with the scale of the damage (and reports of explosions). +
++And the dam is also right along the front lines of the war and had faced shelling and damage during the past year. Right now, the Dnipro is essentially the dividing line between Ukrainian and Russian forces. +
++“This is a massive event, a huge story,” said Peter Gleick, co-founder and senior fellow at the Pacific Institute in California. “The Nova Kakhovka dam is one of the largest dams in Europe.” +
++Early Tuesday local time, reports first emerged of a dam breach, and videos began surfacing of water rushing from the dam. The flooding immediately put communities downriver at risk, and Ukrainian authorities launched evacuation operations. Officials said about 1,300 people had been evacuated so far from Kherson city and other Ukrainian-held areas. About 80 communities total are at risk, including the city of Kherson, according to officials. +
++According to Ukrainian officials, about 40,000 people along the banks of the Dnipro must evacuate — but that population is split between about 17,000 in Ukrainian-controlled territory and another 25,000 or so in the Russian-occupied side of the river. +
++++The Nova Kakhovka dam, a major hydroelectric power plant in southern Ukraine, was severely damaged by an explosion early Tuesday, unleashing flooding near the front lines.
+— The Washington Post (@washingtonpost) June 6, 2023 +
Ukrainian officials said the torrent of water left thousands of people at risk and complicated evacuation… pic.twitter.com/9Nc1DlzK4I +
+Russian officials, meanwhile, downplayed the emergency a bit, though evacuations have reportedly started in some Russian-controlled towns. Vladimir Saldo, the Russia-appointed governor of the Kherson region, said on Telegram that the dam breach “will not greatly affect the situation in the Kherson region. Even a large-scale evacuation of people will not be required.” +
++++Russia-appointed Kherson oblast governor Saldo, speaking right in front of the flooded streets of Novaya Kakhovka:
+— Max Fras (@maxfras) June 6, 2023 +
“Everything is fine in Novaya Kakhovka, people go about their daily business like any day” pic.twitter.com/oTZ8fxMY0O +
+Water was quickly rushing out of the reservoir, with the peak of the flooding expected Wednesday, around noon local time, according to officials, adding urgency to evacuation efforts. Ukrainian officials accused Russia of continuing to shell flood-affected areas. +
++Beyond the immediate emergency, the dam destruction poses risks to the environment, ecology, drinking supply, and energy infrastructure — all in different and complex ways. +
++The area near the Dnipro River is heavily mined, and flood waters could dislodge those explosives. Already there are reports of contamination of industrial chemicals in the Dnipro River. “The surrounding areas, in the Kherson region, Mykolaiv region, they rely on the water for irrigation purposes, for agricultural purposes, and of course, drinking water,” said Maksym Chepeliev, senior research economist at the Center for Global Trade Analysis at Purdue University. +
++Another place at risk of losing access to a water supply is Crimea, which Russia illegally annexed in 2014. At the time, Ukraine blocked off a canal that flowed to the peninsula. But after Russia’s invasion in 2022 and Moscow took control of the dam, it restarted the water supply to Crimea, at substantial cost. Though most goes to agriculture and only a fraction goes to drinking water, Russian officials have already said that the canal is at risk because of the dam damage. +
++Ukrhydroenergo, the Ukrainian state-owned operator of Ukraine’s hydroelectric plants, said that the machine hall inside the Kakhovka Hydroelectric Power Plant was completely destroyed, but so far, the threat to Ukraine’s power grid and electricity supply is pretty contained. Since the plant was seized by Russian forces in the early days of the war, it had not currently been supplying electricity to territory controlled by Ukraine, said Oleksandr Diachuk, leading researcher officer in the Department of Energy Sector Development and Forecasting at the Institute for Economics and Forecasting of the National Academy of Sciences of Ukraine. +
++But that power plant isn’t the one everyone is concerned about. That distinction goes to the Zaporizhzhia nuclear power plant, which is about 75 miles northeast of the dam. That plant relies on water from the reservoir to cool its nuclear reactors. Ukrainian and international nuclear officials have so far said that the dam break poses no “immediate risk” to the plant. The reactors at the power plant have been shut down for many months because of the war, so although they still need to be cooled, they need less water than they would if they were active. Rafael Grossi, head of the International Atomic Energy Agency, said in a statement that the reservoir could supply water to the plant for “a few days” and that the cooling ponds were full, and could provide additional sources of water. (The power plant is also not at risk of flooding.) +
++The Zaporizhzhia plant, in the middle of a war zone, has remained a perpetual possible catastrophe throughout the war, and while those risks are contained now, they have not gone away. “The fact that things are under control now is great, but the situation is very volatile there [at the Zaphorizhia nuclear power plant]. And it’s just something that is an additional thing for us to worry about,” Gleick said. +
++Experts I spoke to cited a litany of potential dire environmental, humanitarian, and ecological risks. Biodiversity destroyed as the reservoir empties. Chemicals leaching into the Dnipro River, polluting water that communities depend on. Those pollutants could travel downstream, into the Black Sea, and contaminate fishing waters. It could affect irrigation levels for wheat and watermelon crops in the region, further choking off food supplies. +
++It will also force the evacuation of thousands who survived a year and a half of artillery shelling, bombs, and war. This flooding would be a disaster at any time, but amid the conflict, it is a potential war crime, one more humanitarian crisis piled on top of all the others, and another years-long rebuilding project Ukraine must take on. +
++“It’s not necessarily easy to mobilize during peacetime,” said Nickolai Denisov, deputy director of the Geneva-based Zoï Environment Network, referring to the disaster response. “During wartime, it’s even more difficult, and it definitely distracts resources from other tasks.” +
++These kinds of disasters are omnipresent in war, but it has become something of a feature of Russia’s invasion of Ukraine. Moscow has systematically targeted Ukrainian infrastructure, and in this case, they had full access to the dam and its facilities. Ukraine has engaged in sabotage efforts against Russian infrastructure, but usually on Russian soil or on strategic targets. +
++US and Western officials have not confirmed publicly who was behind the attack, though the statements have alluded to Russian responsibility. The US said it was aiming to declassify intelligence about the explosion soon. +
++“All things considered, one must naturally assume that this was an aggression perpetrated by the Russian side in order to stop Ukraine’s offensive aimed at liberating its own land,” German Chancellor Olaf Scholz said Tuesday. +
++The timing of this likely explosion is impossible to ignore. Ukraine has been planning to mount a counteroffensive to retake territory for months, and as spring inches into summer, it now seems as if Kyiv is at least laying the groundwork for that major assault. +
++This week, Western officials said they noticed an increase in fighting in the past few days in the east, in Donetsk, with Ukrainian stepping up artillery attacks and ground assaults, potentially to probe Russian fortifications. +
++This isn’t close to the Nova Kakhovka dam, but many Ukraine observers have long pointed to areas in the south as a possible staging point for any operation because it would allow Ukraine to cut off the “land bridge” Russia has built from occupied territories to Crimea. +
++The area now flooded out by the dam breach could potentially have been one attack point, and now it definitely cannot be. But it also probably wasn’t the most likely one, either. Russia was pretty well dug in on its side of the Dnipro, and crossing a river is not exactly an easy operation in the best of times. Ukraine’s forces are likely limited in their ability to conduct an operation like that. +
++Which is also why, if Russia is responsible, this isn’t a hugely strategic move. The flood waters could wash away some of Russia’s fortifications in the Kherson region. And while it may consume Ukrainian resources and attention, it could do the same for Russia, which controls areas that will be affected by this catastrophe. +
++“The motivations for both sides are lacking,” said Emil Kastehelmi, an open source intelligence and military analyst who has been following Russia’s war in Ukraine. +
++But, Kastehelmi pointed out, that doesn’t always matter, especially when it comes to Moscow’s motivations. “As we have seen, they can make huge decisions that might not be beneficial to them. A good example is this whole war that they are waging.” +
++Former New Jersey Gov. Chris Christie is joining the race. +
++Former New Jersey Gov. Chris Christie is the latest Republican to join a growing field of candidates challenging former President Donald Trump for the presidency in 2024. +
++Christie filed paperwork to run for president Tuesday ahead of formally launching his candidacy at an event in New Hampshire. Once a Trump defender, he’s already proved willing to go head to head with the former president, offering criticism of his reluctance to debate, his unwillingness to accept the results of the 2020 election, and calling him a “coward” and “puppet of Putin.” He’s said that he wouldn’t support Trump even if the former president wins the Republican nomination in 2024. +
++It’s a remarkable 180-degree turn for someone who was previously a close ally of Trump, briefly headed his White House transition team, and helped him prepare for debates in 2020. But it’s not clear how that turn will win him support among the many Republican voters who still approve of Trump’s performance in office and have rallied behind him since his indictment in New York, which they perceive as a politically motivated attack. +
+ ++If anything, Christie’s attacks on Trump might spare other GOP candidates from having to go on offense against the former president, who has been known to eviscerate his opponents with mud-slinging and name-calling. That’s what he did to Christie in the 2016 presidential primary, where the former governor finished sixth before ultimately endorsing Trump for the nomination. +
++Christie is likely to run on his record as a moderate governor, though his tenure as New Jersey’s executive was marred by the “Bridgegate” scandal. His aides allegedly orchestrated a plot to close lanes at a bridge that serves as a main artery to New York City in retaliation against a local mayor who did not back his reelection campaign. He continues to deny any knowledge of the plot, despite witnesses in the criminal trial of his aides testifying to the contrary. By the end of his second term, his approval rating had fallen to 15 percent. +
++Christie’s entry nevertheless adds to the competition against Trump, who some Republicans see as a liability in a general election. Not only is Trump the subject of several ongoing civil and criminal investigations, but he’s broadly unpopular. He lost his reelection bid in 2020, and his chosen candidates broadly underperformed in the 2022 midterms. +
++Still, it’s likely to be a tough primary for anyone who’s not Trump. The former president, who announced his candidacy in November, has been increasingly dominant in polling. His closest competitor, Florida Gov. Ron DeSantis, is trailing him by more than 30 percentage points on average as of early June. +
++Besides Trump and DeSantis, no other candidate has received double-digit support in recent weeks. That includes former United Nations ambassador and South Carolina Gov. Nikki Haley and right-wing activist Vivek Ramaswamy, who kicked off their campaigns in February. South Carolina Sen. Tim Scott, who announced in May, has polled near the bottom of the pack. But it’s early in the 2024 cycle, and those numbers could change as candidates consolidate donors, attract endorsements, and expand their campaigns. +
++A broad GOP field may in some ways strengthen Trump’s candidacy, however. The more candidates announce, the greater the competition in the alternative-to-Trump lane. +
++“Everybody sort of agrees we’re going to lose if we [run Trump] again,” said Patrick Hynes, a GOP strategist based in New Hampshire. “But with multiple candidates talking about getting into the race, it just fortifies Trump’s position. And so it’d be really nice if we could just have a united front.” +
++Here are the contenders — besides Trump — so far. +
++Florida Gov. Ron DeSantis is seen as the most viable challenger to Trump. He won reelection by nearly 20 points in 2022, helping usher a red wave into the once-swing state of Florida even though Republican candidates underperformed practically everywhere else in the midterms. But he’s running far behind Trump in the polls, and there are questions as to whether he can run a campaign that feels distinct from MAGA but still has enough general appeal to be successful. +
+ ++DeSantis has been carefully cultivating a national profile for years by making Florida a locus of conservative policymaking that has inspired copycat legislation across the US. He’s promoted popular conservative stances on nearly every culture war issue, including attacking LGBTQ rights, minimizing Covid-19, curtailing abortion access, and eliminating parts of school curriculums deemed too liberal. He worked with the state legislature this session to enact that agenda in Florida, which he is touting as his “blueprint” for America. +
++Beyond just legislating to the right, DeSantis has ensured that Florida will likely stay red for the foreseeable future. In the 2022 redistricting cycle, he pushed for a new, gerrymandered congressional map that ultimately heavily benefited Republicans; the party flipped three House seats in the midterms. He expanded the base, winning counties like Miami-Dade that Republicans haven’t carried in decades, while appearing to make more headway with Latino voters. He raised more than $200 million last cycle, breaking the record for gubernatorial races. +
++Still, he has had a tough few months. He signed an ultra-restrictive six-week abortion ban in Florida that some GOP donors worry will be unpalatable to general election voters. He’s locked in a high-stakes fight with Disney in which he’s suffered loss after loss after loss, neutralizing his ability to claim victory over “woke” corporations. He has left Trump’s attacks largely unanswered for fear of alienating the base. He has already made a few gaffes on subjects from Ukraine to chocolate pudding (allegedly). And there are questions about his likability. +
++He’s trying to carve out his own lane in the primary by running to the right of Trump on issues like Covid-19 and abortion and attempting to draw a contrast with Trump’s bombastic leadership style. But in many ways, his candidacy doesn’t mark a departure from Trumpism. The Florida governor was once a protégé of the former president and employs the same rhetoric to articulate culture war grievances. Their campaign platforms also share many of the same policies. Certainly, DeSantis would have to contort himself to look like a moderate in a general election against President Joe Biden or another Democrat. +
++After months of speculation, former Vice President Mike Pence has filed paperwork for a run with the Federal Election Commission. He is expected to formally launch his campaign June 7 in Iowa, home to many of the Christian right voters he’s hoping to court. His biggest challenge will be stepping out from the shadow of Trump, his one-time running mate from whom he has severed ties. +
++He previously told CNBC that the GOP is “going to have better choices” than the former president. And in an interview with NPR last November, he said he thought Trump was “wrong” in insisting that he won the 2020 election and that he was “reckless” with his words and actions on the day of the January 6 insurrection at the US Capitol. +
++That might not win him any favor among Trump loyalists. But as a prominent evangelical, Pence is hoping to appeal to religious conservatives’ views on abortion, religious liberty, and education. He already seems to be doing so, promoting his memoir, So Help Me God, at megachurches around the country. +
+ ++Though the Supreme Court’s decision to overturn Roe v. Wade dampened GOP gains in the midterms, Pence hasn’t tempered his anti-abortion rhetoric. He has called for a national abortion ban and has thrown his weight behind a proposal by Sen. Lindsey Graham (R-SC) that would ban abortion after 15 weeks of pregnancy, and a ban on abortion pills. +
++Beyond abortion, Pence’s policy group, Advancing American Freedom, has laid out a platform that includes an expansion of 529 college savings plans so they can be used for K-12 schools, promoting the rights of health care providers to decline to perform certain services on the basis of moral or religious objections, and rolling back climate change-related regulations. +
++The question is whether that’s enough to distinguish him from Trump. His agenda touts many of the policies advanced by the Trump-Pence administration, including the still-incomplete construction of the border wall and the United States-Mexico-Canada Agreement. +
++Scott, the three-term South Carolina senator and only Black Republican in the chamber, has framed much of his candidacy around pushing back against Democrats’ views on systemic racism and other disparities in the US. Over the past few years, he’s repeatedly cited his own success as negating the idea that Black Americans are disadvantaged by systematic racism and as proof that anyone can pull themselves up by their bootstraps. +
+ ++In an April video launching a committee to explore a potential 2024 run, Scott describes how he grew up in poverty, was raised by a single mother in South Carolina, and became a member of the US Senate. +
++“They know the truth of my life disproves their lies,” Scott said of Democrats. “I know America is a land of opportunity, not a land of oppression. I know it because I’ve lived it.” +
++As a senator, Scott has struck a similar tone on race, simultaneously acknowledging its role in American life while arguing that racism is largely something that infects individuals rather than being something for society to grapple with. He has previously called out discrimination he’s faced by police, including being pulled over at traffic stops, for example, while calling law enforcement a “noble” profession. Scott touched on these themes during a recent listening tour in Iowa and South Carolina, as well, urging audiences to acknowledge the progress that the US has made. +
++As an evangelical, Scott is also making abortion restrictions a pillar of his campaign. He recently voiced support for a six-week abortion ban in his home state that has now been blocked in court. He has also said that he would enact a 15-week national ban on abortion or “the most conservative pro-life legislation Congress can pass” if elected president. +
++He’s also echoed standard Republican talking points criticizing “Biden liberals” and touting conservative positions on issues like immigration and crime. Legislatively, Scott is known for serving as the GOP’s lead negotiator on police reform and as the sponsor of bipartisan legislation to establish “opportunity zones”’ that intend to drive investment to low-income areas via tax incentives. +
++In early April, former Arkansas Gov. Asa Hutchinson, a longtime Trump critic, joined the GOP field. +
++Hutchinson, a former federal prosecutor who worked on former President Bill Clinton’s impeachment, previously told ABC that he thought Trump should withdraw from the race in light of the criminal charges he’s facing in connection to hush money payments made to the porn star Stormy Daniels during his 2016 campaign. But Hutchinson also acknowledged that Trump probably won’t do that and there’s nothing stopping him from carrying on. +
++“I mean, first of all, the office is more important than any individual person. And so for the sake of the office of the presidency, I do think that’s too much of a sideshow and distraction, and he needs to be able to concentrate on his due process,” Hutchinson said. +
+ ++Hutchinson served eight years as Arkansas governor before stepping down in January because he was term-limited. While in office, he pushed a conservative agenda centered on a near-total ban on abortion without exceptions for cases involving rape and incest, a law banning trans women from participating in school sports teams, and bans on Covid-19 vaccine mandates and state and local mask mandates. +
++He later expressed regret at the lack of exceptions to the abortion ban and that he wanted to reverse the ban on mask mandates amid an August 2021 surge in coronavirus cases. +
++Though she had previously dismissed the prospect of running against Trump if he sought reelection, Trump’s US ambassador to the United Nations and former South Carolina governor Nikki Haley announced in mid-February that she’s running. +
++Haley framed herself as a moderate candidate relative to Trump who can win in a general election. “Republicans have lost the popular vote in seven of the last eight presidential elections. That has to change,” Haley said in her announcement video. “It’s time for a new generation of leadership.” +
++The daughter of Indian immigrants, Haley is centering her pitch for the presidency on foreign policy. In particular, she’s suggested that she would take a hardline stance against America’s foes abroad. She had one of the highest approval ratings of anyone in the Trump administration and was well-respected by her peers on the UN Security Council even when espousing controversial policy decisions, such as Trump’s withdrawal from the Iran nuclear deal, the Paris climate accords, and the UN Human Rights Council. +
+ ++In an environment where most Americans cite government and inflation as the top issues facing the US, it’s not clear whether that foreign policy experience will resonate with voters. But Haley has conservative credentials, too. +
++She won the South Carolina governorship in 2011 with the support of the conservative Tea Party wing of the Republican Party and former Alaska Gov. Sarah Palin. She went on to tighten voter ID laws, oppose Syrian refugee resettlement in the state, and earn bipartisan praise for signing a bill to take down the Confederate flag from the state capitol after a gunman killed nine Black churchgoers in Charleston in 2015. In her announcement video, she hit typical conservative priorities, railing against the “socialist left” while calling for securing the border and fiscal responsibility. +
++But she’s also waded into culture war battles. At a campaign event in May, she went on a rant against a trans influencer who partnered with Bud Light, a collaboration that resulted in a widespread conservative boycott of the brand. She also declared herself to be “unapologetically pro-life” while avoiding questions about whether she would enact a national abortion ban. +
++If Haley prevails, she would be the first woman and first Asian American to win the GOP nomination for president, adding to the list of firsts she has already achieved: South Carolina’s first woman governor and the first Indian American to serve in a statewide office there. +
++The son of Indian immigrants, a former biotech founder, and author of the New York Times bestseller Woke, Inc., Ramaswamy made his name railing against socially responsible investing on cable news shows. Over the past few years, he’s been dubbed “the CEO of Anti-Woke, Inc.” by the New Yorker and has come out with a second book, Nation of Victims: Identity Politics, the Death of Merit and the Path Back to Excellence. Recently, he’s been on a listening tour that included stops in New Hampshire, the second state to cast votes in the presidential primaries. +
++All that led to his announcement for president in February. In his announcement video, he staked his candidacy on combating the “woke left” and what he referred to as “new secular religions like Covidism, climatism, and gender ideology.” +
++“This is psychological slavery, and that has created a new culture of fear in our country that has completely replaced our culture of free speech in America,” he said in the video. +
+ ++His campaign appears as if it will center culture wars: He told former Fox News host Tucker Carlson after jumping into the race that his top priorities include ending affirmative action, “complete decoupling” from China, reenvisioning US immigration policy based on “merit,” and using the American military to combat drug cartels in Central America. +
++While well-known in conservative circles, Ramaswamy would need to find a way to pivot his message to make it more appealing to independents and moderates in a general election. +
++First, though, he will face rivals with far greater platforms, name recognition, donor networks, and war chests — many of whom have spent years developing their own brand of his politics. He’s making some headway in putting himself on the radar with a packed schedule of media appearances that has forced some heavy hitters in the field to take him seriously. +
++Conservative radio host Larry Elder, a frequent talking head on Fox News, announced his long-shot candidacy in May. He has never held political office but led the race to replace California Gov. Gavin Newsom, a Democrat, in an unsuccessful recall campaign in 2021. +
++“America is in decline, but this decline is not inevitable. We can enter a new American Golden Age, but we must choose a leader who can bring us there,” he tweeted of his decision to run for president. +
+ ++Elder, a vocal Trump supporter, has espoused conservative stances on issues from abortion rights to pandemic restrictions, including mask mandates. And as a Black man, he has critiqued the Black Lives Matter movement and called the idea of systemic racism a “lie,” even though he had framed his policies in the recall election as benefiting Black people. +
++He also attributed rising crime in 2021 to a policing pullback spurred by Democratic policies. “When you reduce the possibility of a bad guy getting caught, getting convicted and getting incarcerated, guess what? Crime goes up,” he told the Los Angeles Times. +
++He’s been polling below potential candidates that haven’t yet entered the presidential race, however, so it’s hard to see a path forward for his candidacy. +
++Update, June 6, 3:55 pm ET: This story was originally published on February 23 and has been updated multiple times, most recently to include Christie’s announcement. +
ISSF Junior World Cup | India bags two more golds, medal tally reaches 11 - India picked up two more golds at the ongoing International Shooting Sport Federation (ISSF) World Cup Junior
‘Padel is a wonderful concept for anyone familiar with other racquet sports’ - HYDERABAD
Domingo Oramas named Gokulam’s new coach - KOZHIKODE
Women’s Jr Asia Cup Hockey | India looks to draw against Chinese Taipei to make SF - Unbeaten India would look to seal their semifinal berth when they face Chinese Taipei in their final pool match
WTC Final Day 1 | Warner misses out on fifty, Australia 73/2 at lunch - India picked a lone spinner in all-rounder R. Jadeja, while K.S. Bharat retained his place as the wicketkeeper ahead of Ishan Kishan; R. Ashwin left out.
Autorickshaw drivers fleece commuters, flout norms in Kollam - With surge in customers after school reopening, most drivers refuse to follow fares approved by the State government and force passengers to pay exorbitant rates
Manipur women hold torchlight marches across valley districts - They called for the implementation of the National Register of Citizens, saying the territorial integrity of the State should never be compromised.
Kaziranga mahouts caught for consuming rare turtles - Action against the trio was taken under relevant sections of the Wildlife (Protection) Act of 1972
Environment Day observed at Kollam school -
India has one of the best airfare regimes; there should be no ‘gouging’: Akasa Air CEO - “Gouging is what the government is worried about… as an airline fraternity, we should ensure that there is no gouging,” Akasa Air CEO Vinay Dube said
Ros Atkins unpacks the Ukraine dam breach - The BBC’s analysis editor looks at what we know about the Ukraine dam collapse at Nova Kakhovka.
Pope Francis, 86, to have abdominal surgery - The 86-year-old is being hospitalised for a third time in two years, amid persistent health issues.
Ukraine war: Wagner boss rubbishes Russian claims of Ukrainian casualties - Moscow says it inflicted 3,700 casualties on Kyiv on Monday, but Yevgeny Prigozhin calls the claim “absurd”.
Ukraine war: Kyiv says troops advance on eastern front - Ukraine says its has gained ground near Bakhmut, as Russia claims to have thwarted a new attack.
Ukraine war: Wagner detains Russian officer over ‘drunk’ attack - In a video posted online, the officer says he fired on a Wagner vehicle because he dislikes the group.
FBI warns of increasing use of AI-generated deepfakes in sextortion schemes - Deepfake videos show real people engaged in fake sex. - link
15-inch MacBook Air hands-on: Just what some folks were asking for - Apple hasn’t reinvented anything here, but we like options. - link
Hands-on with Apple Vision Pro: This is not a VR headset - This was the best headset demo I’ve ever seen. But there’s room for improvement. - link
J&J’s COVID vaccine is dead in the US; FDA revokes authorization - The withdrawal leaves the two mRNA vaccines and the Novavax protein subunit vaccine. - link
Dell in hot water for making shoppers think overpriced monitors were discounted - It happened on Dell’s Australia website, but misleading sale claims are common. - link
A man is walking home late at night when he sees a woman in the shadows. “Twenty bucks,” she says… -
++He’s never been with a prostitute before, so excitedly he says, what the hell +
++They are going at it for a minute when all of a sudden a light flashes on them—it’s a policeman. +
++“What’s going on here, people?” asks the officer. +
++“I’m making love to my wife,” the man answers indignantly. +
++“Oh, I’m sorry,” says the cop, “I didn’t know.” +
++“Well,” said the man, “to tell the truth neither did I until you flashed that light on her face.” +
+ submitted by /u/HelpingHandsUs
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If Stranger Things was British it’d be called -
++Bit Odd Innit? +
+ submitted by /u/original_don_dada
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As part of the merger, the PGA will control holes 1-8 and 12-18. -
++The Saudis do 9-11. +
+ submitted by /u/Reg_Cliff
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When Bill and Hillary Clinton got married, Bill informed Hillary that he had a shoebox under the bed, and she was never to open it under any circumstances. Hillary agreed and promised to never open the box. -
++Hillary respected his wish as the years went by and kept her promise. But after several years of marriage, Hillary’s curiosity got the best of her. She opened the box and found several hundred dollars in cash, and a couple of empty beer cans. +
++She felt guilty, and confessed to Bill that she had opened the shoebox, apologizing profusely. Bill said it was okay, but Hillary asked him, “what are the beer cans for?” +
++Bill replies “Hillary, every time I was unfaithful to you, I drank a beer and promised never to do it again.” Hillary is taken aback, but not surprised. She thought well there was Monica, maybe one other woman, I guess that’s not too bad. It’s all good. He was the president and had some flings here and there. +
++She then asks Bill “what’s all the cash for?” Bill says “well, every time the box got full, I took it to the recycling center for the deposit.” +
+ submitted by /u/MaroonTrucker28
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A Mexican man who spoke no English went into a department store to buy socks. -
++He found his way to the menswear department, where a young lady offered to help him. +
++“Quiero calcetines,” said the man. +
++“I don’t speak Spanish, but we have some very nice suits over here,” said the salesgirl. +
++“No, no quiero trajes. Quiero calcetines,” said the man. +
++“Well, these shirts are on sale this week,” declared the salesgirl. +
++“No, no quiero camisas. Quiero calcetines,” repeated the man. +
++“I still don’t know what you’re trying to say. We have some fine pants on this rack,” offered the salesgirl. +
++“No, no quiero pantalones. Quiero calcetines,” insisted the man. +
++“These sweaters are top quality,” the salesgirl probed. +
++“No, no quiero sueter. Quiero calcetines,” said the man. +
++“Our undershirts are over here,” fumbled the salesgirl, beginning to lose patience. +
++“No, no quiero camisetas. Quiero calcetines,” the man repeated. +
++As they passed the underwear counter, the man spotted a display of socks and happily grabbed a pair. Holding them up he proclaimed, “Eso sí que es!” +
++“Why didn’t you just spell it in the first place?!” yelled the salesgirl. +
+ submitted by /u/ThatOnePogger
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