diff --git a/archive-covid-19/27 August, 2023.html b/archive-covid-19/27 August, 2023.html new file mode 100644 index 0000000..23b0b48 --- /dev/null +++ b/archive-covid-19/27 August, 2023.html @@ -0,0 +1,188 @@ + +
+ + + ++Background: Regular exercise and community engagement may slow the rate of function loss for people with dementia. However, the evidence is uncertain regarding the cost-effectiveness and social return on investment (SROI) of home exercise with community referral for people with dementia. This study aimed to compare the social value generated from the in-person PrAISED programme delivered before March 2020 with a blended PrAISED programme delivered after March 2020. Methods: SROI analysis was conducted alongside a randomised controlled trial (RCT). Of 205 patient participants and their carers who completed cost data, 61 completed an in-person programme before March 2020. Due to COVID-19 pandemic restrictions, 144 patient participants completed a blended programme consisting of a combination of in-person visits, phone calls and video conferencing with multidisciplinary team (MDT) members. SROI analysis compared in-person and blended delivery formats. Five relevant and material outcomes were identified: three outcomes for patient participants (fear of falling, health-related quality of life, and social connection); one outcome for carer participants (carer strain index), and one outcome for the NHS (health service resource use). Data were collected at baseline and a 12-month follow-up. Results: The in-person PrAISED programme generated SROI ratios ranging from 0.58 Great Britain Pound (GBP) to 2.33 GBP for every 1 GBP invested. In-person PrAISED patient participants gained social value from improved health-related quality of life, social connection, and less fear of falling. In-person PrAISED carer participants acquired social value from less carer strain. The NHS gained benefit from less health care service resource use. However, the blended PrAISED programme generated lower SROI ratios ranging from a negative ratio to 0.08 GBP : 1 GBP. Conclusion: Compared with the blended programme, the PrAISED in-person programme generated higher SROI ratios for people with early dementia. During the COVID-19 pandemic and its restrictions, a blended delivery of the programme and the curtailment of community activities resulted in lower SROI ratios during this period. An in-person PrAISED intervention with community referral is likely to provide better value for money than a blended one with limited community referral, despite the greater costs of the former. +
++Objectives Identify workplace risk factors for SARS-Cov-2 infection, using data collected by a United Kingdom electricity-generating company. Methods Using a test-negative design case-control study we estimated the odds ratios (OR) of infection by job category, site, test reason, sex, vaccination status, vulnerability, site outage, and site COVID-19 weekly risk rating, adjusting for age, test date and test type. Results From an original 80,077 COVID-19 tests, there were 70,646 included in the final analysis. Most exclusions were due to being visitor tests (5,030) or tests after an individual first tested positive (2,968). Women were less likely to test positive than men (OR=0.71; 95% confidence interval=0.58-0.86). Test reason was strongly associated with positivity and although not a cause of infection itself, due to differing test regimes by area it was a strong confounder for other variables. Compared to routine tests, tests due to symptoms were highest risk (94.99; 78.29-115.24), followed by close contacts (16.73; 13.80-20.29) and looser work contacts 2.66 (1.99-3.56). After adjustment, we found little difference in risk by job category, but some differences by site with three sites showing substantially lower risks, and one site showing higher risks in the final model. Conclusions Infection risk was not associated with job category. Vulnerable individuals were at slightly lower risk, tests during outages were higher risk, vaccination showed no evidence of an effect on testing positive, and site COVID-19 risk rating did not show an ordered trend in positivity rates. +
++Introduction Between March 2020-June 2021, over 30 million COVID-19 cases were reported in India. We assessed the COVID-19 response across the US Mission India (US Embassy New Delhi, US Consulates â Mumbai, Hyderabad, Chennai and Kolkata) to plan future mitigation efforts and fill gaps in knowledge about COVID-19 transmission in a unique community like the US Mission. Method We described COVID-19 mitigation activities undertaken by the five US Mission India posts and conducted a secondary analysis of case investigation and contact tracing program data collected by the Health Unit from March 2020âJuly 2021. Results US Mission in India, in collaboration with multiple internal agencies, initiated COVID-19 mitigation activities in March 2020. Activities included educational sessions, training for infection prevention and control, health and safety assessments, and the development of standard operating procedures (SOPs). The Health Unit and US CDC India office initiated COVID-19 case investigations and conducted contact tracing. Between March 2020-July 2021, 636 COVID-19 cases (72% males), including 48 clusters (size range 2-10 cases), were reported. Overall case fatality rate was 1.5%. Of case patients, 82% (523) were Indians, and 18% (113) were Americans. On presentation, 22% (138/625) of cases were asymptomatic. The median time from symptom onset to notification to the Health Unit was three days (Interquartile range 1-5). The Health Unit identified 2,484 contacts (positivity rate 25%). Frequency of case presentation in the US Mission India closely resembled the pattern of COVID-19 waves in India. The attack rates ranged over the time period between 10-19%, the highest at 19% in Delhi. Conclusions COVID-19 mitigation strategies were implemented in collaboration with multiple agencies and helped prevent the transmission of COVID-19 and large COVID-19 clusters in the US Mission India. +
++We demonstrate that heterogeneity within host populations in the perceived risks associated with infection can amplify the chance that superspreading occurs during the crucial, early stages of an epidemic. Under our behavioural model, individuals who are less concerned about the risks of infection are more likely to be infected and to attend larger sized events. For directly communicable diseases, such as COVID-19, this leads to infections being introduced at rates above the population prevalence to events that are most conducive to superspreading, for fixed overall transmission levels. We develop a computational framework for evaluating within-event risks and derive a small-scale reproduction number to measure how introductions and transmission heterogeneities determine the number of infections resulting from an event of given duration. This generalises earlier frameworks and both quantifies and clarifies how event-scale dynamics depend on population-level characteristics. As event duration and size increase, our reproduction number converges to the widely used basic reproduction number, R0. We show that even moderate levels of heterogeneity in the perceived risks associated with infection can substantially increase the risk that disproportionately large numbers of infections are generated at larger events, as compared to assuming homogeneous perceptions of risk across the host population. Behavioural dynamics, which remain understudied in the context of epidemiological modelling, are essential to consider when assessing the risk posed by an invading pathogen in the early stages of an infectious disease epidemic. +
++Introduction: We assessed protection conferred by COVID-19 vaccines and/or prior SARS-CoV-2 infection against Omicron-associated severe outcomes during successive sublineage-predominant periods. Methods: We used a test-negative design to estimate protection by vaccines and/or prior infection against hospitalization/death among community-dwelling, PCR-tested adults aged >50 years in Ontario, Canada between January 2, 2022 and June 30, 2023. Multivariable logistic regression was used to estimate the relative change in the odds of hospitalization/death with each vaccine dose (2-5) and/or prior PCR-confirmed SARS-CoV-2 infection (compared with unvaccinated, uninfected subjects) up to 15 months since the last vaccination or infection. Results: We included 18,526 cases with Omicron-associated severe outcomes and 90,778 test-negative controls. Vaccine protection was high during BA.1/BA.2 predominance, but was generally <50% during periods of BA.4/BA.5 and BQ/XBB predominance without boosters. A third/fourth dose transiently increased protection during BA.4/BA.5 predominance (third-dose, 6-month: 68%, 95%CI 63%-72%; fourth-dose, 6-month: 80%, 95%CI 77%-83%), but was lower and waned quickly during BQ/XBB predominance (third-dose, 6-month: 59%, 95%CI 48%-67%; 12-month: 49%, 95%CI 41%-56%; fourth-dose, 6-month: 62%, 95%CI 56%-68%, 12-months: 51%, 95%CI 41%-56%). Hybrid immunity conferred nearly 90% protection throughout BA.1/BA.2 and BA.4/BA.5 predominance, but was reduced during BQ/XBB predominance (third-dose, 6-month: 60%, 95%CI 36%-75%; fourth-dose, 6-month: 63%, 95%CI 42%-76%). Protection was restored with a fifth dose (bivalent; 6-month: 91%, 95%CI 79%-96%). Prior infection alone did not confer lasting protection. Conclusion: Protection from COVID-19 vaccines and/or prior SARS-CoV-2 infections against severe outcomes is reduced when immune-evasive variants/subvariants emerge and may also wane over time. Our findings support a variant-adapted booster vaccination strategy with periodic review. +
++Background Extreme but discrete fine particle <2.5ÎŒm (PM2.5) exposure is associated with higher prevalence of respiratory symptoms. It is unknown whether these effects abate, persist, or worsen over time, nor whether COVID-19 exacerbates PM2.5 effects. Methods We analysed longitudinal survey data from a cohort residing near a 2014 coalmine fire in regional Australia. A 2016/2017 survey included n=4,056 participants, of whom n=612 were followed-up in 2022. Items include questions about 7 respiratory symptoms, history of COVID-19, and time-location diaries that were combined with geospatial models of fire-related PM2.5. Associations were examined using logistic and mixed-effects logistic regressions. Results PM2.5 exposure predicted higher prevalence of chronic cough and current wheeze 2-3 years post-fire. At the 2022 follow-up, PM2.5 exposure was associated with worsening prevalence of chronic cough and possibly current wheeze. While were no detectable interaction effects between PM2.5 and COVID-19, participants with a history of COVID-19 exhibited more significant associations between PM2.5 exposure and respiratory symptoms. Discussion Short-term but extreme PM2.5 may increase the long-term prevalence of chronic cough, while COVID-19 may exacerbate the effect on other respiratory symptoms. +
++The 2022 mpox outbreak has spread rapidly across multiple countries in the non-endemic region, mainly among men who have sex with men (MSM), while China only has limited recorded importation and no local outbreak. We constructed probabilistic models to simulate the risk of mpox importation in mainland China, with the help of reported monkeypox cases during this multi-country outbreak and the international air-travel data. And we further evaluated the mpox outbreak potential given that undetected mpox infections were introduced into men who have sex with men, considering different transmissibility, population immunity and population activity. We found that the reduced international air-travel volume and stringent border entry policy decreased about 94% and 69% mpox importations respectively. Once a mpox case is introduced into active MSM population with almost no population immunity, the risk of triggering local transmission is estimated at 42%, and would rise to >95% with over six cases. Our study demonstrates the key role of the reduced international air-travel volume and stringent border entry policy during the COVID-19 pandemic on reducing mpox importations, and the subsequent risk of triggering local outbreaks among MSM. +
++Background Surveillance of COVID-19/SARS-CoV-2 dynamics is crucial to understanding natural history and providing insights into the populationâs exposure risk and specific susceptibilities. This study investigated the seroprevalence of SARS-CoV-2 antibodies, its predictors, and immunological status among unvaccinated patients in Cameroon. Materials and Methods A multicentre cross-sectional study was conducted between January and September 2022 in the town of Douala. Patients were consecutively recruited, and data of interest were collected using a questionnaire. Blood samples were collected to determine Immunoglobin titres (IgM and IgG) by ALFA, CD4+ cells by flow cytometry, and interferon gamma (IFN- Îł) and interleukin-6 (IL-6) by ELISA. Results A total of 342 patients aged 41.5 ± 13.9 years were included. Most participants (75.8%) were asymptomatic. The overall prevalence of IgM and IgG was 49.1% and 88.9%, respectively. Ageusia and anosmia have displayed the highest positive predictive values (90.9% and 82.4%) and specificity (98.9% and 98.3%). The predictors of IgM seropositivity were being aged 60 â 70 years (aOR = 0.54, p = 0.02) and ageusia (aOR = 9.31, p = 0.01), whereas those of IgG seropositivity included health facility (aOR = 0.23, p = 0.02) and ageusia (aOR = 0.21, p = 0.04). CD4+, IFN-Îł, and IL-6 were impaired in seropositive individuals, with a confounding role of socio-demographic factors or comorbidities. Conclusion Although the WHO declared the end of COVID-19 as a public health emergency, the findings of this study indicate the need for continuous surveillance to adequately control the disease in Cameroon. +
+THE EFFECT OF ARGININE AND GLUTAMINE ON COVID-19 PATIENTS OUTCOME: A RANDOMIZED CLINICAL TRIAL - Condition: Â COVID-19
Intervention:  Dietary Supplement: Neomune
Sponsors:  Universitas Sriwijaya;  M. Djamil General Hospital
Completed
Study of Obeldesivir in Children and Adolescents With COVID-19 - Condition: Â COVID-19
Intervention: Â Drug:Â Obeldesivir
Sponsor:  Gilead Sciences
Not yet recruiting
KAND567 Versus Placebo in Subjects Hospitalized With COVID-19 - Condition: Â Covid19
Interventions:  Drug: KAND567;  Drug: Microcrystalline cellulose
Sponsor:  Kancera AB
Terminated
Immunogenicity and Safety of AdCLD-CoV19-1 OMI as a Booster: A COVID-19 Preventive Vaccine in Healthy Volunteers - Conditions: Â COVID-19; Â Vaccines
Interventions: Â Biological:Â AdCLD-CoV19-1Â OMI; Â Biological: Comirnaty Bivalent 0.1mg/mL (tozinameran and riltozinameran)
Sponsor:  Cellid Co., Ltd.
Not yet recruiting
A Pilot Clinical Evaluation of AsteproÂź Nasal Spray for Management of Early SARS-CoV-2 Infection - Condition: Â COVID-19
Interventions:  Drug: Experimental: Primary Cohort;  Other: Placebo Comparator: Primary Cohort - Placebo
Sponsor:  University of Chicago
Active, not recruiting
Using Text Messages to Boost COVID-19 Vaccine Booking Rate - Conditions:  Vaccination Hesitancy;  COVID-19
Interventions: Â Behavioral: Behavioural science-informed text messages; Â Behavioral:Â Control
Sponsors:  The Behavioural Insights Team;  Public Health England;  Department of Health and Social Care;  NHS England and NHS Improvement
Completed
Digital Health Literacy on COVID-19 for All: Co-creation and Evaluation of Interventions for Ethnic Minorities and Chinese People With Chronic Illnesses in Hong Kong - Conditions:  Digital Health Literacy;  COVID-19
Intervention:  Behavioral: Digital health literacy intervention
Sponsor:  The Hong Kong Polytechnic University
Not yet recruiting
Ivermectin to Prevent SARS-CoV-2 (COVID-19) Hospitalisation in Subjects Over 50 - Conditions: Â COVID-19; Â SARS-CoV-2
Interventions: Â Drug:Â Ivermectin; Â Drug:Â Placebo
Sponsor:  Insud Pharma
Terminated
Methylprednisolone in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) - Condition: Â Post-COVID-19Â Syndrome
Intervention: Â Drug:Â Methylprednisolone
Sponsor:  Charite University, Berlin, Germany
Not yet recruiting
COVID-19 Vaccination Hesitancy in Adults With Sickle Cell Disease - Conditions:  Sickle Cell Disease;  COVID-19 Vaccine;  Vaccine Hesitancy
Intervention: Â Behavioral: SCD-specific COVID-19 vaccination information (SCVI) video
Sponsors:  Duke University;  American Society of Hematology
Not yet recruiting
Leveraging Community Health Workers to Combat COVID-19 and Mental Health Misinformation in Haiti, Malawi, and Rwanda - Conditions:  Mental Health;  COVID-19;  Misinformation
Interventions: Â Behavioral: Card-Sorting Activity (Pre-intervention design); Â Behavioral: SMS Crafting (Pre-intervention design); Â Behavioral:Â SMSÂ Messaging
Sponsors:  Harvard Medical School (HMS and HSDM);  Partners in Health
Active, not recruiting
Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh - Condition:  Pulmonary Pathology
Intervention:  Behavioral: Pulmonary Rehabilitation
Sponsor: Â Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Active, not recruiting
A Study to Learn About New COVD-19 RNA Vaccine Candidates for New Varients in Healthy Individuals - Conditions: Â SARS-CoV-2Â Infection; Â COVID-19
Intervention:  Biological: BNT162b2 (Omi XBB.1.5)
Sponsors:  BioNTech SE;  Pfizer
Not yet recruiting
Pulmonary Artery Pressure in COVID-19 Survivors - Condition:  Pulmonary Hypertension Secondary
Intervention: Â Diagnostic Test: right heart catheterization (RHC).
Sponsor:  Mansoura University Hospital
Enrolling by invitation
Preliminary Efficacy of a Technology-based Physical Activity Intervention for Older Korean Adults During the COVID-19 Pandemic - Conditions:  Cardiovascular Health;  Physical Function
Intervention:  Behavioral: Golden Circle
Sponsor:  University of Illinois at Urbana-Champaign
Completed
Azvudine and mortality in patients with coronavirus disease 2019: A retrospective cohort study - CONCLUSION: Our results reveal that in patients with COVID-19, FNC administration was associated with a significantly reduced 28-day mortality.
Hexamethylene Amiloride Binds the SARS-CoV-2 Envelope Protein at the Protein-Lipid Interface - The SARS-CoV-2 envelope (E) protein forms a five-helix bundle in lipid bilayers whose cation-conducting activity is associated with the inflammatory response and respiratory distress symptoms of COVID-19. E channel activity is inhibited by the drug 5-(N,N-hexamethylene) amiloride (HMA). However, the binding site of HMA in E has not been determined. Here we use solid-state NMR to measure distances between HMA and the E transmembrane domain (ETM) in lipid bilayers. ^(13) C, ^(15) N-labeled HMA isâŠ
Effectiveness of Bivalent Omicron-Containing Booster Vaccines against SARS-CoV-2 Omicron Variant among Individuals with and without Prior SARS-CoV-2 Infection - In this study, we evaluated the effectiveness of the bivalent mRNA COVID-19 vaccines against the Omicron variant in individuals with or without prior SARS-CoV-2 infection history. We assessed the SARS-CoV-2-specific neutralizing antibody in serum samples by surrogate virus neutralizing assay (sVNT) and determined the serumâs neutralizing capacity against the Omicron BA.5 by a plaque reduction neutralizing test (PRNT50). The results of the sVNT assay demonstrate a higher percentage of inhibitionâŠ
Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters - The successful development of a chemoprophylaxis against SARS-CoV-2 could provide a tool for infection prevention that is implementable alongside vaccination programmes. Nafamostat is a serine protease inhibitor that inhibits SARS-CoV-2 entry in vitro, but it has not been characterised for chemoprophylaxis in animal models. Clinically, nafamostat is limited to intravenous delivery and has an extremely short plasma half-life. This study sought to determine whether intranasal dosing of nafamostatâŠ
Interchangeability of the Assays Used to Assess the Activity of Anti-SARS-CoV-2 Monoclonal Antibodies - The recent global COVID-19 pandemic caused by SARS-CoV-2 lasted for over three years. A key measure in combatting this pandemic involved the measurement of the monoclonal antibody (mAb)-mediated inhibition of binding between the spike receptor-binding domain (RBD) and hACE2 receptor. Potency assessments of therapeutic anti-SARS-CoV-2 mAbs typically include binding or cell-based neutralization assays. We assessed the inhibitory activity of five anti-SARS-CoV-2 mAbs using ELISA, surface plasmonâŠ
Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein - Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and continues to threaten humanity due to the persistent emergence of new variants. Therefore, developing more effective and broad-spectrum therapeutic and prophylactic drugs against infection by SARS-CoV-2 and its variants, as well as future emerging CoVs, is urgently needed. In this study, we screened severalâŠ
Clinical Utility of SARS-CoV-2 Antibody Titer Multiplied by Binding Avidity of Receptor-Binding Domain (RBD) in Monitoring Protective Immunity and Clinical Severity - Conventional serum antibody titer, which expresses antibody level, does not provide antigen binding avidity of the variable region of the antibody, which is essential for the defense response to infection. Here, we quantified anti-SARS-CoV-2 antibody binding avidity to the receptor-binding domain (RBD) by competitive binding-inhibition activity (IC50) between SARS-CoV-2 S1 antigen immobilized on the DCP microarray and various RBD doses added to serum and expressed as 1/IC50 nM. The bindingâŠ
Airway Epithelial-Derived Immune Mediators in COVID-19 - The airway epithelium, which lines the conducting airways, is central to the defense of the lungs against inhaled particulate matter and pathogens such as SARS-CoV-2, the virus that causes COVID-19. Recognition of pathogens results in the activation of an innate and intermediate immune response which involves the release of cytokines and chemokines by the airway epithelium. This response can inhibit further viral invasion and influence adaptive immunity. However, severe COVID-19 is characterizedâŠ
Lavandula austroapennina: Assessment of the Antiviral Activity of Lipophilic Extracts from Its Organs - In a framework aimed at the recovery and enhancement of medicinal plants endemic to the territory of the Cilento and Vallo di Diano National Park, Lavandula austroapennina N.G. Passal., Tundis and Upson has aroused interest. An insight into the chemical composition of the corolla, calyx, leaf, stem, and root organs was carried out following ultrasound-assisted maceration in n-hexane. The obtained lipophilic extracts were explored using ultra-high-performance chromatography coupled toâŠ
Antiviral Effect of Candies Containing Persimmon-Derived Tannin against SARS-CoV-2 Delta Strain - Inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the mouth has the potential to reduce the spread of coronavirus disease 2019 (COVID-19), due to the virus being readily transmitted by dispersed saliva. Persimmon-derived tannin has strong antioxidant and antimicrobial activity owing to its strong adhesion to proteins, and it also exhibited antiviral effects against non-variant and Alpha-variant SARS-CoV-2 in our previous study. In this study, we first demonstratedâŠ
Immunogenicity of Mix-and-Match CoronaVac/BNT162b2 Regimen versus Homologous CoronaVac/CoronaVac Vaccination: A Single-Blinded, Randomized, Parallel Group Superiority Trial - (1) Background: This study aimed to compare the immunogenicity of the mix-and-match CoronaVac/BNT162b2 vaccination to the homologous CoronaVac/CoronaVac regimen. (2) Methods: We conducted a simple-blinded randomized superiority trial to measure SARS-CoV-2 neutralization antibodies and anti-spike receptor binding domain (RBD) IgG concentrations in blood samples of participants who had received the first dose of CoronaVac vaccine followed by a dose of BNT162b2 or CoronaVac vaccine. The primaryâŠ
New Imidazolium Alkaloids with Broad Spectrum of Action from the Marine Bacterium Shewanella aquimarina - The continuous outbreak of drug-resistant bacterial and viral infections imposes the need to search for new drug candidates. Natural products from marine bacteria still inspire the design of pharmaceuticals. Indeed, marine bacteria have unique metabolic flexibility to inhabit each ecological niche, thus expanding their biosynthetic ability to assemble unprecedented molecules. The One-Strain-Many-Compounds approach and tandem mass spectrometry allowed the discovery of a Shewanella aquimarinaâŠ
Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study - Prior evidence indicates the potential central role of the acid sphingomyelinase (ASM)/ceramide system in the infection of cells with SARS-CoV-2. We conducted a multicenter retrospective observational study including 72,105 adult patients with laboratory-confirmed SARS-CoV-2 infection who were admitted to 36 AP-HP (Assistance Publique-HĂŽpitaux de Paris) hospitals from 2 May 2020 to 31 August 2022. We examined the association between the ongoing use of medications functionally inhibiting acidâŠ
Protective Role of Vitamin K3 on SARS-CoV-2 Structural Protein-Induced Inflammation and Cell Death - The structure proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as nucleocapsid protein (N protein) and envelop protein (E protein), are considered to be the critical pro-inflammatory factors in coronavirus disease 2019 (COVID-19). Vitamin K3 has been reported to exert an anti-inflammatory effect. In this study, we investigated the protective effects of vitamin K3 on SARS-CoV-2 N protein induced-endothelial activation and SARS-CoV-2 E protein induced-cell death inâŠ
Establishment of Replication Deficient Vesicular Stomatitis Virus for Studies of PEDV Spike-Mediated Cell Entry and Its Inhibition - The porcine epidemic diarrhea virus (PEDV) is a highly contagious and virulent enteric coronavirus that causes severe enteric disease in pigs worldwide. PEDV infection causes profound diarrhea, vomiting, and dehydration in pigs of all ages, resulting in high mortality rates, particularly among neonatal piglets. The spike glycoprotein (S) of PEDV plays a crucial role in binding to the host cell receptor and facilitating fusion between the viral and host membranes. Pseudotyped viral particlesâŠ
Trumpâs Mug Shot Is His True Presidential Portrait - He might be angry in the mug shot; he might even be scared. But he damn sure doesnât look surprised. Nobody is. - link
What a Heat Wave Does to Your Body - The human body is a remarkably effective cooling machineâbut it has a limit. - link
Vivek Ramaswamy Is Not the Next Trump - Many in the press have declared the entrepreneur and political novice âTrumpâs heir.â The comparison sells the former President short. - link
âBraiding Sweetgrass,â and a Lesson in Extreme Heat - Parul Sehgal visits Robin Wall Kimmerer, who set out to bridge the gap between Western science and Indigenous teaching. Plus, Dhruv Khullar looks at extreme heat and the body. - link
The Harsh Glare of Justice for Donald Trump - On the ex-Presidentâs snarly mug shot from the Fulton County Jail and a 2024 reality of Trump, Trump, and more Trump. - link
+Actually useful ways to help children with homework, bullying, and mental health. +
++In early 2020, around the onset of Covid-19 lockdowns, Jessica Mungekar noticed her seventh grade honor student, Layla, retreat. âI knew that she felt really uncomfortable and she wanted to fall into the background,â Mungekar says. âShe didnât want to be noticed and I didnât quite understand it.â +
++Meanwhile, Layla was keeping the source of her pain secret from her mother: She was being bullied and was struggling with her identity as a biracial teen in a predominantly white town. Layla feared if she told her mom about the extent of the bullying, Jessica would have called the school, making the problem even worse. +
++Things came to a head the summer before Laylaâs first year of high school when she shared with her mom details of a traumatic event. Layla urged her mother not to make decisions on her behalf in the aftermath. Instead, Jessica went into what she calls âmama bear modeâ and made demands of her daughter: Cut off contact with these friends, join these extracurricular activities, you are only allowed out of the house during these hours. Layla felt like her autonomy was being taken away. +
++Over the course of a few months, mother and daughter worked to repair their relationship and communication. Now, Jessica says she is sure to listen to Layla instead of immediately offering advice, validates her daughterâs feelings, and gives her freedom to express herself. For her part, Layla confides in her mother all the time, even about her dating life. Her friends often seek out Jessica for counsel, too. âSheâs become a safe place where people go to get advice,â Layla, now 16, says. âSheâs joyous and doesnât pass judgment.â +
++Students are faced with a daily barrage of potential stressors: a demanding course load, tricky social dynamics, managing both their time and emotions. In a four-year study designed to estimate the prevalence of mental disorders in kindergarteners through 12th graders, findings showed one in six students exhibited enough symptoms to meet the criteria for one or more childhood mental disorders, such as anxiety disorders and attention-deficit/hyperactivity disorder. According to a 2019 Pew Research Center report, 61 percent of teens said they felt a lot of pressure to get good grades. About 22 percent of 12- to 18-year-old students reported being bullied during the school year in 2019, per a National Center for Education Statistics survey. None of these statistics takes into account the toll of the pandemic, which set students back academically and had negative effects on their mental health. +
++Once kids leave the house, parents and other adults in their lives have little influence on their studentsâ school days. Unable to witness or guide children through the difficulties in and out of the classroom, parents often get piecemeal or incomplete views of how their kids spent the last hours, especially if the child is young and canât adequately verbalize their struggles or frustrations. Signs that a student may be experiencing hardship at school include increased irritability, difficulty sleeping or lack of sleep, and changes in appetite, says Jessica Kendorski, the chair of the school psychology department and professor at the Philadelphia College of Osteopathic Medicine. They may also say they feel sick in order to stay home, when in reality they may be stressed or anxious about school, Kendorski says. +
++Another indicator of a struggling child includes extreme people-pleasing, says Meredith Draughn, the school counselor at B. Everett Jordan Elementary School in Graham, NC, and the 2023 American School Counselor Association Counselor of the Year. High school students may also exhibit a âfreezeâ response, Draughn says. âItâs like well, that kid just doesnât care, right? That kidâs super apathetic,â she says. âWhat we find when we dig into it more is theyâre so overwhelmed by everything thatâs happening that they just choose to do nothing because they donât know how to address it.â +
++What, then, is the right way to support the students in your life? The tactics will vary based on the age of your child and the issues theyâre facing. Regardless of your approach, experts say to always keep your kids in the loop of any decisions youâre making about their emotional and academic success. +
++From homework to challenging classes, students experience a number of academic hurdles. Sometimes, they may fail a test or drop the ball on a project. While some students may criticize themselves (âIâm not smart enoughâ) or claim the material was too difficult, parents should promote a growth mindset: the ability to learn from setbacks, implement new processes, and improve. âYou want to praise the effort and the strategies that they used,â Kendorski says. âIf they fail something, you want to talk through âWhy did you fail this? Letâs talk about what you can do to be successful next time.ââ +
++A fixed mindset is one where people believe their skills are set in stone and they have no possibility of improving. When students in his classroom share fixed mindset sentiments like âI canât do this,â elementary school teacher Josh Monroe is quick to amend the statement: âYou canât do this yet.â The power of yet helps students âunderstand that you donât have to know it all right now â and itâs important that you donât, thatâs how you grow,â he says. +
++While itâs crucial to encourage a growth mindset with students who use negative self-talk, like âIâll never learn thisâ or âIâm not good enough,â a fixed mindset can also backfire if you constantly tell a student âYouâre so smart,â Kendorski says. âWhen things start to get really difficult, you might find kids that donât want to take chances,â she says, âbecause they think that if I fail, Iâm going to lose that âIâm so smartâ title.â Instead, she says, focus on accomplishments based on effort and strategies: âIâm really proud of you for organizing a study group with your friends.â +
++To help ensure your kids get their homework done and prepare for tests, Kendorski encourages a routine: dedicating a time and a place for schoolwork. If your student retains information more effectively if they study for a little bit each day instead of cramming, offer that as an option. +
++When the kid in your life asks for help with homework and youâre a little rusty on, say, algebra, donât feel ashamed to admit you donât know how to solve the problem, Draughn says. Monroe recommends the online educational tool Khan Academy, which features videos that guide both parents and students through all levels of educational concepts and lessons. For additional academic resources, reach out to your studentâs teacher who will know about after-school tutoring sessions or extra guidance, Draughn says. âGoing to teachers early and often, when help is needed, is the most crucial part of it,â she says, âbecause there are those programs, but they do fill up pretty quickly.â +
++School can be a social minefield, with kids learning how to independently interact with peers and regulate their emotions. If your child shares that theyâre being picked on or ostracized in school, Draughn suggests that you first validate their experience and never downplay their emotions. Ask them what level of support they want: Do they think it would be helpful to talk to a school counselor or a teacher? Or do they prefer you to reach out to the teacher directly? In Layla Mungekarâs experience, she would have opted for her mother to not interfere with her social life. âLetting them lead the way on that is important,â Draughn says. âThey may say, I feel like I have the tools to handle this â and thatâs great. Then you check in. But doing nothing and just not mentioning it again is not going to help anything.â +
++You might also start counseling your kid on self-advocacy and assertiveness at home, too, Draughn says, helping them identify moments where they should speak out against bad behavior and pointing out trustworthy adults to whom they can report issues, regardless of whether they are on the receiving end or have witnessed another student being bullied. âIf someone is making you feel socially or physically unsafe, thatâs the time to speak up,â says Tracee Perryman, the author of Elevating Futures: A Model For Empowering Black Elementary Student Success. Again, only reach out to the school yourself after talking it over with your kid. +
++However, your child may simply be shy and reserved, not the victim of bullying. Perryman says to help build confidence with the kids in your life by reminding them that what they have to say is important and they have valuable interests and insights worth sharing with others. +
++When it comes to social media, Jessica Mungekar discovered teens will âdo what theyâre going to do, whether you want them to or not,â she says. Itâs better to listen if your child is involved with social media-related conflict, remind them they are not in trouble, and support them as you work to create a plan together. âI think itâs important in this day and age for kids to have social media because otherwise they get [alienated] by their peers,â Layla Mungekar says. âBut itâs a lot safer when parents have those conversations, like yeah, this is going to happen and when it does happen, you should feel safe to come to me and not be blamed for that.â +
++Experts emphasize the transitory nature of school. While itâs crucial for students to apply themselves academically and make strides socially, remind them that one speed bump, fight with a friend, blunder, or bad grade will not drastically alter the trajectory of their lives. âItâs better that I make those mistakes now,â Layla says, âwhile I have someone there to help me.â +
++Just like adults, kids can get stressed due to the demands of school and extracurriculars, as well as conflicts with friends and family. If kids are sleeping very late on weekends or too tired to do activities they typically enjoy, like spending time with friends, they might need more balance in their schedules, Perryman says. +
++Ask your kid directly: âAre you playing T-ball three nights a week because you like it or you feel like you have to?â or âYou had three extracurriculars last semester and it was really overwhelming for you. Do you want to pick two for this coming semester?â Draughn suggests. Remind your kid that just because they step away from a hobby now doesnât mean they canât come back to it in the future. Make sure students have one weeknight and one weekend day solely devoted to downtime, too, Draughn says. However, donât discount the fact that sports and other activities can be rejuvenating for kids, even if theyâre not resting. +
++Parents and supportive adults are quick to problem-solve for the kids in their lives, but Kendorski stresses the importance of asking, âDo you want me to listen? Or do you want me to help?â Your child might just want to vent about a tough baseball practice. When Layla wants validation and a hug from her mom, she asks her âto be a waterfall.â When sheâs feeling less emotionally charged, then Layla and her mom can problem-solve. +
++For high-achieving students who may be stressed about grades and college applications, Kendorski suggests asking your kids what story theyâre telling themselves about success. For example, they might worry that a bad test grade means theyâll never get into their dream college. Help them map more realistic outcomes by thinking about the absolute worst-case scenario and alternative paths. For example, the worst that could happen if they fail a single test is maybe they get a C for the quarter. But reinforce how if they study and complete all their homework, the likelihood of failing is minimized. +
++Remember not to make your stress their stress. Children are intuitive and can pick up on how the adults in their lives are feeling, Kendorski says. Instead of turning away from uncomfortable emotions, encourage open communication. If youâre disappointed in a mediocre grade, try saying, âIâm feeling a little bummed about the C on that test, but thatâs my issue. I know you work hard and with some more practice, I know youâll do better next time.â +
++Parents should always validate their childâs struggles and encourage caring for their mental health. Whether theyâre seeking support from a trusted teacher or you think theyâd benefit from speaking with a therapist â ask them how theyâd feel about chatting with a professional before scheduling an appointment â remind them that âmental health is health,â Draughn says. That matters more than any test score. +
+Auto workers at the âDetroit Threeâ auto companies could stop work on September 14. +
++Members of the United Auto Workers on Friday voted overwhelmingly to authorize a strike at the so-called Detroit Three automobile manufacturers â Ford, General Motors, and Stellantis â should those companies fail to offer a competitive contract by the time the current one expires September 14. +
++The strike authorization is the latest in a series of high-profile labor actions in the US over the past year, including the ongoing SAG-AFTRA and Writerâs Guild of America strikes, a UPS strike authorization that resulted in a fair contract, and a threatened US railway strike thwarted by the government in December. While all of these actions point to a more visible labor presence in the economy, the UAW strike authorization â much like the SAG-AFTRA and WGA strike â is about more than just the conditions under which workers will perform their duties. What the UAW wants, too, is a say in what the industry looks like as it changes with technological developments like the switch to electric vehicles. +
++The UAW represents about 150,000 workers at the three companies â 97 percent of whom voted to authorize the strike. Shawn Fain, the president of the UAW, indicated that the union would not extend the September 14 deadline to ratify a new four-year contract. Union talks with the automakers started in July, according to Reuters, but have progressed slowly since then, Fain said. âWe have a lot of options that we are looking at but extension on the contract is not one of them.â +
++Fain and the UAW are asking for a series of wage increases and improved or reinstated benefits that offset labor concessions over the past few decades, and which would eliminate the two-tiered employment system that the Detroit Three factories have had in place since 2007. +
++US labor unions enjoyed power and popular support until the 1970s and 1980s, when a combination of a series of corruption scandals and the Reagan administrationâs breaking of the Professional Air Traffic Controllers Organization (PATCO) strike in 1981 greatly weakened collective bargaining. Globalization, especially after the North American Free Trade Agreement (NAFTA) came into effect in the 1990s also weakened worker power, since companies could â and did â move their operations to countries where labor was cheaper, decimating entire industries and swaths of the country. +
++Thatâs led to depressed wages despite high inflation, as well as a decrease in benefits like pensions, even as the cost of living increases. And in 2023, companies can now use the specter of artificial intelligence and automation as a bargaining chip against workersâ futures. +
++Like all union contracts, the UAWâs is extremely ambitious; unions go into negotiations knowing theyâll have to compromise on some elements of what theyâre asking for, so they aim high. In the case of the UAW, as well as in other striking industries, the contracts are trying to both regain lost ground and protect workers for the future. +
++âWeâre fed up,â Fain told Reuters. âWeâve sat back for decades while these companies continue to just take and take and take from us.â +
++Real wage growth, representing actual purchasing power, has stagnated since the 1980s, only reaching 1983 levels during the Covid-19 pandemic. Overall, wages havenât grown at the same rate as the cost of living, 401(k) plans replaced pension benefits, putting more pressure on the worker to save for retirement â despite a boom in worker productivity over the past 50 years. +
+ ++The UAW is striking to reverse some of these changes, by including in its contract a demand for a defined-benefit pension and to re-establish the retiree medical benefit program. The union is also demanding a 46 percent wage increase over the life of the contract to keep up with the increased cost of living, as well as reinstituting a cost-of-living allowance which was eliminated in 2009 following the auto industry bailout. With major auto producers on the brink of bankruptcy, the UAW renegotiated its contract at the behest of the federal government. +
++But a major driver of the strike is actually a two-tiered wage system first instituted in the UAWâs 2007 contract; workers hired before that are in the first tier and started at about $28 per hour, while second-tier workers start at between $16 and $19 per hour â a rate that has barely increased over the past decade. The second-tier class of workers grows as first-tier workers retire and are replaced by new second-tier workers, ultimately bringing down wages for an increasing number of workers â who also increasingly make up UAW membership. +
++There are several reasons that labor has become more visible over the past few years, and workers seem increasingly willing to demand more from their employers. That doesnât necessarily mean the US is in a new era of labor power, and even that phrase doesnât mean what it did in the first half of the 20th century. +
++Amazonâs Chris Smalls has been a visible figure demanding the right to unionize and better conditions for his fellow workers, and the combined SAG-AFTRA and WGA strikes have been highly visible because they target the entertainment industry, putting peopleâs favorite TV shows and movies on hold until studios and the unions can agree to fair contracts â including the use of generative AI in writing and shooting films and TV shows. +
++Similarly, the UAW strike is not only about raising individual standards of living but also looking forward to the effect that technology could have on jobs in that sector. As the industry shifts from combustion engines to battery-powered electric cars, manufacturing will need fewer workers with different skills, as Michigan State University professor of employment relations Peter Berg told Michigan State University Today. +
++If the strike action does move forward â and Berg told Vox in an interview that he believes it will in some form â it could cost each company as much as $500 billion per week of stopped work, according to Deutsche Bank analyst Emmanuel Rosner. +
++The moment is right for labor to try and claw back losses of the past few decades and try to gain protection and benefits for the future; there is a tight labor market, an aging workforce, high consumer demand, and political and popular support for trade unions. âThese strike actions on the part of labor unions [are saying], âAlright, we have to renegotiate the fundamentals of how work is done,ââ Berg said, and âusing their power to redefine the working conditions going forward.â +
+Imagine a Breitbart comments forum come to life and given immense power over innocent people. Thatâs Judge James Ho. +
++If you could breathe life into 4chan, the dark corner of the Internet where shitposters, edgelords, Groypers, and trolls of all kinds thrive, and then appoint this new lifeform to the federal bench, you would have created Judge James Ho. +
++Ho, appointed by former president Donald Trump in 2018 to the United States Court of Appeals for the Fifth Circuit, recently argued that anti-abortion doctors may seek a court order banning a commonly prescribed abortion medication, because âdoctors delight in working with their unborn patients â and experience an aesthetic injury when they are aborted.â +
++Heâs written that a federal law prohibiting gun possession by people that a court has determined to be a âcredible threat to the physical safety of [their] intimate partnerâ is unconstitutional. Among other things, Ho claimed that this law âshould give us pauseâ because women getting a divorce sometimes seek such court orders as âa tactical leverage deviceâ in their divorce proceedings. +
++Hoâs very first opinion as a judge, a dissenting opinion in a case he did not even hear, claimed that all laws limiting the amount that wealthy donors may give to political campaigns are unconstitutional. Under Hoâs understanding of the Constitution, nothing prevents Harlan Crow, the billionaire Republican donor famous for lavishing gifts on Justice Clarence Thomas, from funding an entire presidential campaign. +
++Also, speaking of Harlan Crow, Ho held his official ceremony swearing him in as a federal judge in Crowâs personal library. +
+++Honored to attend Jim Hoâs swearing in to the Fifth Circuit Court of Appeals today, alongside Justice Clarence Thomas & Judge Jerry Smith. I am confident my good friend Jim will be an extraordinary appellate judge and a principled jurist faithful to the law. pic.twitter.com/s1tWYu2j2c +
+â Senator Ted Cruz (@SenTedCruz) January 5, 2018 +
+Hoâs work, in other words, is often indistinguishable from that of a professional troll. He revels in taking deliberately provocative positions. He often joins a fairly extreme opinion written by a colleague, and then writes separately to take an even more extreme position. His judicial opinions mingle Fox News talking points, menâs rights activism, Federalist Society fantasies, and discredited legal doctrines that are now taught to law students to warn them of the Supreme Courtâs worst mistakes. +
++Ho seems to never miss an opportunity to weigh in on a political controversy. When heâs not writing concurring opinions arguing that the Supreme Court should bring back the Lochner era, an age when conservative justices imposed their own laissez-faire ideology on the rest of the nation, he can often be found lecturing law schools on the evils of âcancel culture.â +
++(That said, Ho did not respond to a request to be interviewed for this piece.) +
++When I speak to other judges, I often hear them use a derisive word to describe this kind of behavior: âauditioning.â Itâs an increasingly common practice among Republican judges itching for a promotion. +
++In his final years as a lower court judge, Justice Neil Gorsuch wrote several opinions laying out his plans to shift power from federal agencies to the judiciary â a high-priority issue for the Federalist Society, which played a key role in picking Trumpâs judges and justices. These opinions reportedly âproved decisiveâ in the Trump White Houseâs decision to give Gorsuch a big promotion. +
++Similarly, in his final year as a lower court judge, Justice Brett Kavanaugh â who previously had a thin record on abortion â went out of his way to convey both in a published opinion and in a speech to a conservative think tank that he opposed Roe v. Wade. Trump picked Kavanaugh for the next seat to open up on the Supreme Court. +
++The most alarming thing about Judge Ho, in other words, isnât his penchant for trolling. It is the very real possibility that he will be rewarded for it. No judge in America has auditioned harder for a Supreme Court appointment in a Republican administration. And, if the next president is Donald Trump, Trump has already shown that he prefers judges who go out of their way to show their loyalty to Republican causes. +
++Lochner v. New York (1905) is one of a handful of decisions that legal scholars refer to as the âanti-canonâ â a list of cases taught to law students as examples of how judges must never, ever behave. The list also includes the pro-slavery decision in Dred Scott v. Sandford (1857) and the segregationist decision in Plessy v. Ferguson (1896). +
++Ho wants to bring back Lochner. +
++Lochner stuck down a New York state law that limited, to 60 hours a week, the amount of time worked by bakery workers. At the time, these workers were typically paid by the day or by the week, so the law had prevented these workers from being forced to work extraordinarily long shifts for no extra pay. +
++Other cases applying Lochnerâs reasoning struck down minimum wage laws and stripped workers of their right to unionize. +
++Lochner was grounded in what it described as the âright of the individual to ⊠enter into those contracts in relation to labor which may seem to him appropriate or necessary for the support of himself and his family.â The idea was that, if a worker entered into a contract to work long hours for little pay, then the law could not alter this contract â even if the contract was itself the product of exploitation or desperation. +
++Lochner, in other words, not only stripped the government of much of its power to protect workers, it did so on the dubious ground that, by insisting that workers adhere to whatever exploitative employment contracts their bosses imposed upon them, the Court was actually defending the rights of those workers. The Court ultimately abandoned Lochner in West Coast Hotel v. Parrish (1937). +
++Ho picked an inauspicious case, Golden Glow Tanning Salon v. City of Columbus, to offer his love letter to Lochner. In it, a Mississippi tanning salon claimed that Covid era lockdowns violated the salon ownerâs âright to work,â a common argument made by modern day libertarians who seek to revive Lochner. (A âright to workâ is synonymous with Lochnerâs so-called right to âenter into those contracts in relation to labor which may seem to him appropriate.â) +
++Though all three judges who heard Golden Glow agreed that the Supreme Courtâs decisions repudiating Lochnerism prevented them from ruling in the tanning salonâs favor, Ho wrote a brief concurring opinion that relied heavily on scholarship by right-wing lawyers arguing that Lochner should be revived. He suggested that the anti-worker right recognized in Lochner has a âbetter historical grounding than more recent claims of right that have found judicial favor.â And he urged the Supreme Court to take up a pending case seeking to revive Lochner (the justices declined to do so). +
++Hoâs passion for the sorts of economic ârightsâ favored by Gilded Age robber barons is matched by his disdain for abortion. He wrote about the âmoral tragedy of abortionâ in one of his judicial opinions. And heâs urged his Fifth Circuit â which is already the most right-wing federal appeals court in the country, and is typically hostile towards reproductive freedom â to be even more aggressive in quashing abortion rights. +
++Just last week, for example, a three-judge panel that includes Ho attempted to ban the drug mifepristone, which is used in more than half of all US abortions. That decision will have no effect, because the Supreme Court preemptively blocked it last April â a pretty clear sign that even this very conservative Supreme Court thinks that the legal arguments against mifepristone are weak. +
++But Ho didnât just join this attempt to ban the drug, in a case called Alliance for Hippocratic Medicine v. FDA, he wrote a separate opinion arguing that his colleagues were insufficiently hostile to abortion rights. +
++Technically, the Fifth Circuitâs majority opinion in Alliance did not purport to ban mifepristone outright, it merely ordered the FDA to reinstate restrictions on the drug that the agency abandoned in 2016. As a practical matter, this order would prevent the drug from being marketed in the United States for at least a few months, because it would take a long time for government regulators and the drug maker to comply with the pre-2016 rules. But Ho would have gone even further, ordering the FDA to rescind its decision to approve the medication way back in 2000. +
++There are so many errors in Hoâs legal reasoning that it would be tedious to list them all here. One of them is that the statute of limitations to challenge an FDA approval of a drug is six years. While there are legitimate reasons that time period can sometimes be extended, Ho canât rescue a lawsuit that was filed more than two decades after mifepristoneâs approval. +
++On guns, Ho joined the Fifth Circuitâs decision in United States v. Rahimi (2023), a decision the Supreme Court is likely to reverse in its upcoming term, holding that people who violently abuse their romantic partners or their partnerâs child have a Second Amendment right to own a gun â even after a court proceeding determines that the abuser is âa credible threat to the physical safety of such intimate partner or child.â +
++Rahimi is another case where Ho joined an alarming decision written by one of his colleagues, and then wrote separately to argue for an even more extreme position. +
++Ho argues that one reason his court should be skeptical of a law seeking to disarm people subject to domestic violence restraining orders is that women who are not victims of abuse allegedly obtain these orders to âsecure [favorable] rulings on critical issues such as [marital and child] support, exclusion from marital residence and property disposition.â +
++As evidence that this is a real problem that actually exists, Ho cites a handful of court decisions â including a 1993 decision by a court in New Jersey that invalidated a restraining order because of a lack of evidence that the man subjected to it was violent, and a 2005 incident where comedian David Letterman was briefly subject to a restraining order before a court tossed that order out. +
++The fact that Ho had to rely on decades-old cases in faraway jurisdictions to show that judges sometimes issue domestic violence restraining orders for invalid reasons is a sign that, maybe, this isnât as big of a problem as Ho makes it out to be. Nevertheless, Ho would potentially arm hundreds of men who have murderous intentions in order to save someone like Letterman from having to go without a firearm for a couple of weeks. +
++Hoâs penchant for tacking to the right of his already quite reactionary colleagues marks him as an outlier, even within a conservative federal judiciary. But heâs hardly an extreme outlier, especially on the far-right Fifth Circuit. +
++In Collins v. Mnuchin (2019), for example, Ho signed onto an opinion by Judge Don Willett that threatened to invalidate every single action taken by the Federal Housing Finance Agency (FHFA), which was created in 2008 to stabilize the US housing market during a historic recession. Had Willettâs approach prevailed in the Supreme Court, it could have potentially collapsed the US housing market and triggered a global economic depression (the Supreme Court voted 8-1 against Willettâs approach). +
++Notably, however, Ho was one of a total of seven judges who signed onto Willettâs attempt to burn down more than a dozen years of work by a federal agency. There is no shortage of judicial arsonists on the Fifth Circuit. +
++Similarly, the Supreme Court will hear several cases in its upcoming term in which it is likely to reverse similarly aggressive decisions by the Fifth Circuit. Those most likely include the Alliance case about mifepristone, as well as the Rahimi guns case, and two decisions declaring the entire the Consumer Financial Protection Bureau unconstitutional and gutting the federal governmentâs power to enforce securities law. +
++The leading contenders for the Republican presidential nomination are already signaling that they want to pick justices who are well to the right of the three already very conservative justices Trump placed on the Supreme Court. In his infamous speech before the January 6 attack on the US Capitol, Trump said that he is ânot happy with the Supreme Courtâ because they supposedly âlove to rule against me.â (When Trump was president, the Court often manipulated its own procedures to rule in Trumpâs favor, but the Court rejected his bid to overturn the 2020 election.) +
++Florida Gov. Ron DeSantis attacked Trumpâs justices in June, claiming that ânone of those three are at the same level of Justices Thomas and Justice Alito,â two justices who fairly consistently vote like Fifth Circuit judges. +
++Ho, meanwhile, is auditioning harder than anyone in the judiciary to catch Trump or DeSantisâs eye. And, even if the next Republican president decides to pick someone less flamboyant for the high court, they will have no shortage of candidates who are eager to light decadesâ worth of settled law â along with entire federal agencies â on fire. +
+Velavan clinches Canberra Open squash title -
Indian women beat Thailand 5-4 in Asian Hockey 5s World Cup Qualifier - Indian women had registered a 7-1 win over Japan in their second match of the tournament on Saturday night
Prudent to keep K.L. Rahul as a wicketkeeper-batter for Asia Cup: Sanjay Bangar - Bangar spoke about KL Rahulâs role in Team India for the upcoming Asia Cup 2023
BCCI president Roger Binny, VP Rajeev Shukla to be in Lahore on PCBâs invitation - The PCB had extended the invitation to all the principal office-bearers of BCCI and it is understood that president and vice-president have got Indian boardâs approval to accept the invitation accorded to them
FC Goa beat Chennaiyin FC 4-1, enter Durand Cup semis - Bikash Yumnam opened the scoring for Chennaiyin in the fifth minute when he found the net from a corner
NGT raises questions on pesticide unit in Tiruvallur functioning before getting approval - The company applied for Consent to Operate (CTO) on March 12 and subsequently, the consent was given after inspection. But, the Bench said, in one of the product pamphlets produced by the unit, the manufacturing date was printed as December 2022
Annual Pavitrotsavams begin at Tirumala in Andhra Pradesh -
Karnataka BJP reiterates demand for reinvestigation into Soujanya rape and murder case - While the Central Bureau of Investigation has failed to find out the real accused, the lone accused in the case, Santosh Rao, was acquitted in June this year
Five-year-old boy drowns in swimming pool at Marina - CM Stalin announced a solatium of âč3 lakh from the Chief Ministerâs Public Relief Fund.
Tamil Nadu government reconstitutes Puthirai Vannar Welfare Board -
Wagner boss Prigozhin confirmed dead in plane crash - Moscow - Genetic analysis of the bodies was carried out following Wednesdayâs crash, Russian officials say.
Ukraine war: Fighter ace and two other pilots killed in mid-air crash - Andrii Pilshchykov won fame taking part in dogfights over Kyiv during the early phase of Russiaâs invasion.
Spain head coach Jorge Vilda criticises âinappropriateâ Luis Rubiales kiss - Spainâs Womenâs World Cup-winning head coach Jorge Vilda has called the moment Luis Rubiales kissed squad member Jennifer Hermoso âinappropriate and unacceptableâ.
Luis Rubiales kissing Jenni Hermoso unleashes social tsunami in Spain - The Spanish FAâs president kissing player Jenni Hermoso on the lips has sparked a national conversation.
Evidence found of German mass execution by French Resistance after D-Day - Casings and coins at a site in central France suggest prisoners were shot by the French Resistance after D-Day.
Four people from four different nations ride SpaceX rocket into orbit - A new Falcon 9 booster also joins SpaceXâs fleet with Saturdayâs launch. - link
Study: Carbon offsets arenât doing their job, overstate impact - Cambridge study says carbon offsets are not nearly as effective as they claim to be. - link
Renegade certificate removed from Windows. Then it returns. Microsoft stays silent. - The certificate, originally spawned by Symantec, was scheduled to be banished years ago. - link
Hands-on with Cherry MX2A switches: A lot less wobble, a little more confusion - Cherry fights mechanical switch copycats with a new, yet familiar, lineup. - link
Trumpâs mug shot was on the Wii News channel, thanks to RiiConnect24 devs - RiiConnect has been offering Wii online services for longer than Nintendo. - link
Two men and a woman are going to hitman school⊠-
++⊠and their teacher takes one of the men out into the hallway, points at a door and says, âIn this room we have your wife. Hereâs a loaded pistol, go in and kill her.â +
++The guy says âOK.â He goes into the room and comes out a few minutes later. He says, âI love her, I canât do it.â +
++The teacher says, âYou donât have what it takes to be a hitman, get out of here.â +
++The teacher then does the same thing with the other guy with the same result. +
++He then takes the woman out into the hallway, points at a door and says, âIn this room we have your husband. Hereâs a loaded pistol, go in and kill him.â +
++She goes into the room and he hears a gunshot and then all hell breaking loose. Thereâs yelling & screaming plus furniture being broken. After about 15 minutes of this the woman comes out looking disheveled and says, âWhy the hell did you put blanks in the gun? I had to beat the son-of-a-bitch yo death.â +
+ submitted by /u/Indotex
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Picture this: A pandemic is unleashed by ticks that live on and around the mouths of alpacas. Global chaos ensues, the disease wipes out 99% of humanity and desperate survivors are forced to live in⊠-
++âŠa post-alpaca lip tick wasteland. +
+ submitted by /u/madazzahatter
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These two guys had just gotten divorces and they swore they would never have anything to do with women again. They were best friends and they decided to move up to Alaska as far north as they could go and never look at a woman again. -
++They got up there and went into a traderâs store and told him, âGive us enough supplies to last two men for one year.â The trader got the gear together and on top of each oneâs supplies he laid a board with a hole in it with fur around the hole. The guys said âWhatâs that board for?â The trader said, âWell, where youâre going there are no women and you might need this.â They said âNo way! Weâve sworn off women for life!â The trader said, âWell. take the boards with you, and if you donât use them. Iâll refund your money next year.â âOkay,â they said and left. +
++Next year this guy came into the traderâs store and said âGive me enough supplies to last one man for one year.â The trader said, âWerenât you in here last year with a partner?â âYeahâ said the guy. âWhere is he?â asked the trader. âI shot himâ said the guy. âWhy?â âI caught him in bed with my board.â +
+ submitted by /u/YZXFILE
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Four musicians are arguing about who gives the best blowjobs in the band. -
++
The first says, âClarinet players are the best, because they can put so much in their mouth and still play beautifully.â
+ ++
The second says, âNo, itâs flute players! They can handle the mouthpiece sensitively while still using their fingers.â
+ ++
The third still disagrees, and says âItâs oboe players, they have refined how to handle wood down to an art form.â
+ ++
The fourth, hearing all this, pauses to think. Finally, he speaks up and says, âNo, youâre all wrong. Truly, itâs French horn players who give the best blowjobs. Their tongue movements are incredibleâŠ
+ ++
âŠbut the only problem is that they have to have their fist up your ass.â
+ ++
(Not mine, heard this from a musician friend today, and Iâm sure itâs much older)
+ + submitted by /u/Owlmanandy
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[NSFW]I Was Surprised When My deadbeat roommate actually had rent money on time -
++âYeah, man, I got a job.â +
++âDoing what?,â I asked. +
++âI hang out in the alley and give blow jobs.â +
++âSounds like a hard way to make money.â +
++âNah, man, my very first night I made $300.05â +
++I scoffed, âWho paid you a nickel?â +
++He said, âThey all did.â +
+ submitted by /u/Woodentit_B_Lovely
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