diff --git a/archive-covid-19/07 May, 2023.html b/archive-covid-19/07 May, 2023.html new file mode 100644 index 0000000..94e4082 --- /dev/null +++ b/archive-covid-19/07 May, 2023.html @@ -0,0 +1,194 @@ + +
+ + + ++Background: One of the major challenges currently faced by global health systems is the prolonged COVID-19 syndrome (also known as long COVID) which has emerged as a consequence of the SARS-CoV-2 epidemic. The World Health Organization (WHO) recognized long COVID as a distinct clinical entity in 2021. It is estimated that at least 30% of patients who have had COVID-19 will develop long COVID. This has put a tremendous strain on still-overstretched healthcare systems around the world. Methods: In this study, our goal was to assess the plasma metabolome in a total of 108 samples collected from healthy controls, COVID-19 patients, and long COVID patients recruited in Mexico between 2020 and 2022. A targeted metabolomics approach using a combination of LC-MS/MS and FIA MS/MS was performed to quantify 108 metabolites. IL-17 and leptin concentrations were measured in long COVID patients by immunoenzymatic assay. Results: The comparison of paired COVID-19/post-COVID-19 samples revealed 53 metabolites that were statistically different (FDR < 0.05). Compared to controls, 29 metabolites remained dysregulated even after two years. Notably, glucose, kynurenine, and certain acylcarnitines continued to exhibit altered concentrations similar to the COVID-19 phase, while sphingomyelins and long saturated and monounsaturated LysoPCs, phenylalanine, butyric acid, and propionic acid levels normalized. Post-COVID-19 patients displayed a heterogeneous metabolic profile, with some showing no symptoms while others exhibiting a variable number of symptoms. Lactic acid, lactate/pyruvate ratio, ornithine/citrulline ratio, sarcosine, and arginine were identified as the most relevant metabolites for distinguishing patients with more complicated long COVID evolution. Additionally, IL-17 levels were significantly increased in these patients. Conclusions: Mitochondrial dysfunction, redox state imbalance, impaired energy metabolism, and chronic immune dysregulation are likely to be the main hallmarks of long COVID even two years after acute COVID-19 infection. +
++Background: Vaccination against SARS-CoV-2 has been deployed in France since January 2021. Evidence was beginning to show that the most vulnerable populations were the most affected by COVID-19. Without specific action for different population subgroups, the inverse equity hypothesis postulates that people in the least deprived neighbourhoods will be the first to benefit. Methods: We performed a spatial analysis using primary data from the vaccination centre of the Avicenne Hospital in Bobigny (Seine-Saint-Denis, France) from January 8th to September 30th, 2021. We used secondary data to calculate the social deprivation index. We performed flow analysis, k-means aggregation, and mapping. Results: During the period, 32,712 people were vaccinated at the study centre. Vaccination flow to the hospital shows that people living in the least disadvantaged areas were the first to be vaccinated. The number of people immunized according to the level of social deprivation then scales out with slightly more access to the vaccination centre for the most advantaged. The furthest have travelled more than 100 kilometres, and more than 1h45 of transport time to get to this vaccination centre. Access times are, on average, 50 minutes in February to 30 minutes in May 2021. Conclusion: The study confirms the inverse equity hypothesis and shows that vaccination preparedness strategies must take equity issues into account. Public health interventions should be implemented according to proportionate universalism and use community health, health mediation, and outreach activities for more equity. +
++During viral infection the structure of host chromatin is modified. It is generally assumed that these chromatin modifications will affect variant-gene mapping, and therefore gene expression. What is not clear is how limitations imposed by host germline risk affect the expression changes that occur with infection induced chromatin remodelling. Critically, this lack of information extends to how germline variants associated with severe SARS-CoV-2 impact on tissue-specific gene expression changes in response to infection-induced chromatin conformation changes. Here we combined temporal chromatin conformation data from SARS-CoV-2 stimulated cells with a lung spatial-eQTL gene expression analysis to contextualise the functional effects and contributions of germline risk on the severe phenotypes observed in SARS-CoV-2. We identify changes in lung-specific SARS-CoV-2 risk variant-gene mapping across the infection time course. Our results provide evidence for infection-induced chromatin remodelling that impacts the regulation of genes associated with the severity of SARS-CoV-2 infection. The gene targets we identified are functionally involved in host chromatin modifications and maintenance and the expression of these genes is amplified by SARS-CoV-2-induced epigenetic remodelling. The effect of this remodelling includes transcriptional changes to gene targets such as SMARCA4, NCOR1, DNMT1, DNMT3a, DAXX, and PIAS4, all critical components of epigenetic control mechanisms and SARS-CoV-2 antiviral activity, along with several genes involved in surfactant metabolism. We show how severe-phenotype-associated eQTLs form and break in an infection time-course-dependent manner that mimics positive feedback loops connecting germline variation with the process of viral infection and replication. Our results provide a novel bridge between existing COVID-19 epigenetic research and demonstrate the critical role of epigenomics in understanding SARS-CoV-2-risk-associated gene regulation in the lung. +
++IMPORTANCE Several pharmacotherapies have been authorized to treat non-hospitalized persons with symptomatic COVID-19. Longitudinal information on their use is needed. OBJECTIVE To analyze trends and factors related to prescription of outpatient COVID-19 pharmacotherapies within the Veterans Health Administration (VHA). DESIGN, SETTINGS, AND PARTICIPANTS This cohort study evaluated non-hospitalized veterans in VHA care who tested positive for SARS-CoV-2 from January 2022 through January 2023, using VHA and linked Community Care and Medicare databases. EXPOSURES Demographic characteristics, regional and local systems of care including Veterans Integrated Services Networks (VISNs), underlying medical conditions, COVID-19 vaccination. MAIN OUTCOMES AND MEASURES Monthly receipt of any COVID-19 pharmacotherapy (nirmatrelvir-ritonavir, molnupiravir, sotrovimab, or bebtelovimab) was described. Multivariable logistic regression was used to identify factors independently associated with receipt of any versus no COVID-19 pharmacotherapy. RESULTS Among 285,710 veterans (median [IQR] age, 63.1 [49.9-73.7] years; 247,358 (86.6%) male; 28,444 (10%) Hispanic; 198,863 (72.7%) White; 61,269 (22.4%) Black) who tested positive for SARS-CoV-2 between January 2022 and January 2023, the proportion receiving any pharmacotherapy increased from 3.2% (3,285/102,343) in January 2022 to 23.9% (5,180/21,688) in August 2022, and declined slightly to 20.8% (2,194/10,551) by January 2023. Across VISNs, the range in proportion of test-positive patients who received nirmatrelvir-ritonavir or molnupiravir during January 2023 was 5.9 to 21.4% and 2.1 to 11.1%, respectively. Veterans receiving any treatment were more likely to be older (adjusted odds ratio [aOR], 1.18, 95% CI 1.14-1.22 for 65 to 74 versus 50 to 64 years; aOR 1.19, 95% CI 1.15-1.23 for 75 versus 50 to 64 years), have a higher Charlson Comorbidity Index (CCI) (aOR 1.52, 95% CI 1.44-1.59 for CCI ≥6 versus 0), and be vaccinated against COVID-19 (aOR 1.25, 95% CI 1.19-1.30 for primary versus no vaccination; aOR 1.47, 95% CI 1.42-1.53 for booster versus no vaccination). Compared with White veterans, Black veterans (aOR 1.06, 95% CI 1.02 to 1.09) were more likely to receive treatment, and compared with non-Hispanic veterans, Hispanic veterans (aOR 1.06, 95% CI 1.01-1.11) were more likely to receive treatment. CONCLUSIONS AND RELEVANCE Among veterans who tested positive for SARS-CoV-2 between January 2022 and January 2023, prescription of outpatient COVID-19 pharmacotherapies peaked in August 2022 and declined thereafter. There remain large regional differences in patterns of nirmatrelvir-ritonavir and molnupiravir use. +
++Wastewater is a discarded human by-product but analyzing it may help us understand the health of communities. Epidemiologists first analyzed wastewater to track outbreaks of poliovirus decades ago, but so-called wastewater-based epidemiology was reinvigorated to monitor SARS-CoV-2 levels. Current approaches overlook the activity of most human viruses and preclude a deeper understanding of human virome community dynamics. We conducted a comprehensive sequencing-based analysis of 363 longitudinal wastewater samples from ten distinct sites in two major cities. Over 450 distinct pathogenic viruses were detected. Sequencing reads of established pathogens and emerging viruses correlated to clinical data sets. Viral communities were tightly organized by space and time. Finally, the most abundant human viruses yielded sequence variant information consistent with regional spread and evolution. We reveal the viral landscape of human wastewater and its potential to improve our understanding of outbreaks, transmission, and its effects on overall population health. +
++Since emergence of the initial SARS-CoV-2 omicron BA.1, BA.2 and BA.5 variants, omicron has diversified substantially. Antigenic characterization of these new variants is important to analyze their potential immune escape from population immunity and implications for future vaccine composition. Here, we describe an antigenic map based on human single-exposure sera and live-virus isolates that includes a broad selection of recently emerged omicron variants such as BA.2.75, BF.7, BQ, XBB and XBF variants. Recent omicron variants clustered around BA.1 and BA.5 with some variants further extending the antigenic space. Based on this antigenic map we constructed antibody landscapes to describe neutralization profiles after booster immunization with bivalent mRNA vaccines based on ancestral virus and either BA.1 or BA.4/5 omicron. Immune escape of BA.2.75, BQ, XBB and XBF variants was also evident in bivalently boosted individuals, however, cross-neutralization was improved for those with hybrid immunity. Our results indicate that future vaccine updates are needed to induce cross-neutralizing antibodies against currently circulating variants. +
++Turkey experienced substantial excess mortality in 2020 and 2021 related to the COVID-19 pandemic. Methods used to estimate excess mortality vary, making comparisons difficult. This study assessed the impact of the COVID-19 pandemic in Turkey, using the TURKSTAT data which became available on February 23, 2023. We applied a quasi-Poisson model to estimate excess mortality during 2020-2021, comparing excess mortality by time periods and socioeconomic factors (SEGE grades). During 2020-2021, Turkey experienced 72,886 excess deaths in 2020 (P-score 16.8%) and 125,540 in 2021 (P-score 28.5%). Excess all-cause mortality varied across SEGE levels, with notable social disparities in pandemic deaths as the highest rates were observed in SEGE 6, the lowest socioeconomic group. An additional 80 excess deaths per 100,000 people were recorded in 2020 and 143 in 2021. This study highlights the importance of a comprehensive approach to address the diverse impacts of the pandemic on health and well-being while considering socioeconomic disparities, and potential areas for improvement in data collection and reporting. +
++BACKGROUND Eye diseases worldwide, including within the United States, are underdiagnosed and undertreated1. A multitude of factors contribute to this deficiency in eye care including, but not limited to, availability of specialists, transportation and mobility barriers, financial burden, lack of education, and poor patient-physician communication and understanding2,3,4. Teleophthalmology, a paradigm of care delivery in which ocular images are interpreted remotely by an eye specialist, has increased in interest since the COVID-19 pandemic, may offer improved access to necessary eye care5. The need for improved access through teleophthalmology is particularly critical for diabetic retinopathy (DR), the leading cause of new cases of blindness among adults aged 20 to 60 affecting more than 100 million patients worldwide6,7. DR arises when elevated levels of blood sugar resulting from either type 1 or 2 diabetes mellitus damage the blood vessels that supply oxygen and nutrients to the retina, the light-sensing part of the eye. The risk of developing DR is directly related to the length of time that a patient has diabetes and usually does not appear for approximately five years after a type 1 diabetes diagnosis, although it may already be present when type 2 diabetes is diagnosed8. In the absence of glycemic control and/or ophthalmic treatment, the disease may progress through three stages of non-proliferative retinopathy (mild, moderate, severe) before proliferative retinopathy develops. Diabetic macular edema can occur with any stage of retinopathy. If DR is diagnosed early, vision loss may be mitigated or prevented9. An annual fundus examination to screen for DR is critical, however, only about half of all patients with diabetes receive proper screening and less than 40% of patients with a high risk of vision loss ever undergo treatment10,11. In 2010, primary care providers (PCPs) delivered clinical care to approximately 90% of individuals with type 2 diabetes, and the proportion has increased over time12. The importance of primary care practitioners ensuring that their diabetic patients receive recommended eye care is reflected in the Healthcare Effectiveness Data and Information Set (HEDIS). This comprehensive set of quality performance measures across six domains of care guide the primary care of chronic medical conditions like diabetes mellitus and includes assessment of whether a diabetic patient receives diabetic eye screening at least every two years13. Attainment of these quality measures is increasingly important for health-system quality ratings and value-based reimbursement models. Practices are increasingly turning to teleophthalmology programs to aid in this goal of care5,14. Traditionally, DR is diagnosed by an eye specialist via an annual in-person fundoscopic examination. However, with appropriate training, non-ophthalmic clinicians and clinical personnel are able to use a fundus camera to take retinal photos that can then be evaluated by an ophthalmologist typically via a store-and-forward model. DR can be determined with high sensitivity and specificity from fundus photography, and a referral for further ophthalmic evaluation or treatment is made for those patients with retinopathy15. Primary care-based teleophthalmology programs have improved the accessibility and cost-effectiveness of DR screening in both rural and urban settings worldwide and are currently being applied to DR screening more commonly than any other ocular pathology16, 17,18. The ongoing COVID-19 pandemic has exacerbated existing barriers and increased the likelihood of ophthalmic appointment postponement or cancellation rendering teleophthalmology services even more critical to DR screening programs19, 20. The prevalence of diabetes in California is more than 40% above the United States national average21. As a means to improve the ophthalmic health of our patients, the Stanford Teleophthalmology Automated Testing and Universal Screening (STATUS) program was developed as a multi-site teleophthalmology DR screening collaboration between the Byers Eye Institute of Stanford (BEIS) and five affiliated primary care clinics throughout the San Francisco Bay Area. The program was initiated two to six months (depending on the site) prior to the onset of the COVID-19 pandemic in the United States and continued to provide remote eye examinations to patients throughout 2020 and 2021. The goal of the program was to evaluate whether the use of teleophthalmology could increase the percentage of patients screened for DR in collaboration with regional primary care clinics. Here, we examine the ability of the 18-month teleophthalmology program to improve and maintain access to DR eye care prior to and during the COVID-19 pandemic. METHODS Clinic Sites Non-mydriatic fundus cameras were deployed at an academic-affiliated primary care site in Santa Clara, CA in September 2019, and in four additional affiliated primary care sites in Los Gatos, Oakland, Hayward, and Pleasanton, CA beginning in February 2020. The primary care sites ranged from 20 miles (25-minute drive) to 42 miles (45-minute drive) away from the BEIS. Store-and-forward teleophthalmology screening for diabetic retinopathy continued at all five locations throughout the study period which ended April 2021. In order to determine whether the teleophthalmology program impacted the adherence rate to annual diabetic eye exams, HEDIS measures at two primary care sites (Pinole, CA and San Pablo, CA) in the same healthcare system that did not deploy the teleophthalmology system were also assessed. The study was approved by the Institutional Review Board at Stanford University. Patient Image Collection and Assessment Patients 18 years or older with type 1 or type 2 diabetes mellitus without a prior DR diagnosis or a DR exam in the past 12 months were offered the opportunity to have fundus photographs taken at the end of their primary care visit. Fundus imaging was performed by a trained medical assistant using the CenterVue DRS fundus camera (Hillrom Inc., Chicago, IL) at the Santa Clara primary clinic site and the TopCon NW400 fundus camera (Welch Allyn Inc., Skaneateles Falls, NY) at the Los Gatos, Oakland, Hayward, and Pleasanton primary care clinics. If medical assistants deemed the image quality to be poor, they repeated image acquisition and did so up to 4 times. The fundus images were forwarded to vitreoretinal specialists at BEIS who evaluated the images within one week. These fundus images were classified as ungradable (such as when opacity, blurring, or decentration impaired visualization of the fundus), or gradable if quality was sufficient for grading of DR. Images of adequate quality had a DR grade assigned in accordance with the International Clinical Diabetic Retinopathy Disease Severity Scale with moderate and severe categories combined on teleophthalmology evaluation (no diabetic retinopathy/mild non-proliferative diabetic retinopathy/moderate to severe non-proliferative diabetic retinopathy/proliferative diabetic retinopathy)22. Patient images were also assessed for the presence of macular edema or other fundus abnormalities. Patients with images of insufficient quality from one or both eyes were recommended to have the images retaken or present for an in-person eye examination. Diagnosis and stage of DR was determined by the eye with more advanced retinopathy. Those with referral-warranted disease were referred for an in-person exam at BEIS or their local ophthalmologist. A subset of patients (N=26) voluntarily presented for a second teleophthalmology screening one year after their first examination. Patient Data Patient files containing information on labs, orders, clinical notes, and patient information were retrieved from The STAnford Research Repository (STARR), an institutional resource for working with clinical data for research purposes. Data was managed and analyzed using Python (version 3.9.0) with Pandas (version 1.3.0). Patients who underwent fundus imaging without a documented assessment by BEIS specialists were excluded (N = 23). For all patients who were seen at BEIS after a referral for in-person examination, data was manually collected from the electronic health record. For analyses comparing patients prior to and during the COVID-19 pandemic, March 16th, 2020, was used as the start of the pandemic since on that date legal stay-at-home orders were announced in Alameda, Contra Costa, Marin, San Francisco, San Mateo, and Santa Clara counties. Longitudinal HEDIS data were only available for three of the teleophthalmology primary care sites and the two non-teleophthalmology comparison sites; two teleophthalmology primary care sites did not have structured HEDIS data available for analysis. +
++Dynamic distribution shifts caused by evolving diseases and demographic changes require domain-incremental adaptation of clinical deep learning models. However, this process of adaptation is often accompanied by catastrophic forgetting, and even the most sophisticated methods are not good enough for clinical applications. This paper studies incremental learning from the perspective of mode connections, that is, the low-loss paths connecting the minimisers of neural architectures (modes or trained weights) in the parameter space. The paper argues for learning the low-loss paths originating from an existing mode and exploring the learned paths to find an acceptable mode for the new domain. The learned paths, and hence the new domain mode, are a function of the existing mode. As a result, unlike traditional incremental learning, the proposed approach is able to exploit information from a deployed model without changing its weights. Pre-COVID and COVID-19 data collected in Oxford University hospitals are used as a case study to demonstrate the need for domain-incremental learning and the advantages of the proposed approach. +
++Background Healthcare workers (HCWs) have experienced high rates of COVID-19 morbidity and mortality. We estimated COVID-19 two-dose primary series and monovalent booster vaccine effectiveness (VE) against symptomatic SARS-CoV-2 Omicron (BA.1 and BA.2) infection among HCWs in three Albanian hospitals during January-May 2022. Methods Study participants completed weekly symptom questionnaires, underwent PCR testing when symptomatic, and provided quarterly blood samples for serology. We estimated VE using Cox regression models (1-hazard ratio), with vaccination status as the time-varying exposure and unvaccinated HCWs as the reference group, adjusting for potential confounders: age, sex, prior SARS-CoV-2 infection (detected by PCR, rapid-antigen test or serology), and household size. Results At the start of the analysis period, 76% of 1,462 HCWs had received a primary series, 10% had received a booster dose, and 9% were unvaccinated; 1,307 (89%) HCWs had evidence of prior infection. Overall, 86% of primary series and 98% of booster doses received were BNT162b2. The median time interval from the second dose and the booster dose to the start of the analysis period was 289 days (IQR:210-292) and 30 days (IQR:22-46), respectively. VE against symptomatic PCR-confirmed infection was 34% (95%CI: -36;68) for the primary series and 88% (95%CI: 38;98) for the booster. Conclusions Among Albanian HCWs, most of whom had been previously infected, COVID-19 booster dose offered improved VE during a period of Omicron BA.1 and BA.2 circulation. Our findings support promoting booster dose uptake among Albanian HCWs, which, as of January 2023, was only 20%. +
++Background: Patients with ischemic stroke and concomitant coronavirus 2019 (COVID-19) infection have worse outcomes than those without this infection. However, research on the impact of COVID-19 infection on outcomes following hemorrhagic stroke remains limited. We aim to study whether concomitant COVID-19 infection leads to worse outcomes in spontaneous intracerebral hemorrhage (ICH).<break><break>Design: We conducted an observational study using data from Get With The Guidelines Stroke, an ongoing, multi-center, nationwide quality assurance registry. <break><break>Methods: We implemented a two-stage design: first, we compared outcomes of ICH patients with and without COVID-19 infection admitted during the pandemic (from March 2020 to February 2021). Second, we compared the same outcomes between ICH patients admitted before (March 2019 to February 2020) and during (March 2020 and February 2021) the pandemic. Main outcomes were poor functional outcome (defined as a modified Rankin Scale of 4 to 6 [mRS] at discharge), mortality and discharge to skilled nursing facility (SNF) or hospice. <break><break>Results: The first stage included 60,091 COVID-19-negative and 1,326 COVID-19-positive ICH patients. In multivariable analyses, ICH patients with versus without COVID-19 infection had 68% higher odds of poor outcome (OR 1.68, 95%CI 1.41-2.01), 51% higher odds of mortality (OR 1.51, CI 1.33-1.71) and 66% higher odds of being discharged to a SNF/hospice (OR 1.66, 95%CI 1.43-1.93). The second stage included 62,743 pre-pandemic and 64,681 intra-pandemic ICH cases. In multivariable analyses, ICH patients admitted during versus before the COVID-19 pandemic had a 10% higher odds of poor outcome (OR 1.10, 95%CI 1.07-1.14), 5% higher mortality (OR 1.05, 95%CI 1.02-1.08) and no significant difference in the risk of being discharged to SNF/hospice (OR 0.93, 95%CI 0.90-0.95). <break><break>Conclusions: The pathophysiology of the COVID-19 infection and changes in healthcare delivery during the pandemic played a role in worsening outcomes in this patient population. Further research is needed to identify these factors and understand their effect on the long-term outcome. +
+Long COVID-19 Syndrome Lifestyle Intervention Study - Condition: Long COVID-19 Syndrome
Intervention: Dietary Supplement: Low carbohydrate diet intervention
Sponsor: University of Southern California
Not yet recruiting
Working Towards Empowered Community-driven Approaches to Increase Vaccination and Preventive Care Engagement - Condition: COVID-19
Interventions: Other: mHealth Outreach; Other: Care Coordination
Sponsors: University of California, San Diego; San Ysidro Health Center
Not yet recruiting
A Coping and Resilience Intervention for Adolescents - Condition: COVID-19 Pandemic
Interventions: Behavioral: Coping and Resilience Intervention for Adolescents; Other: Printing materials of Coping and Resilience Intervention for Adolescents
Sponsor: Taipei Medical University
Enrolling by invitation
Effectiveness of Modified Diaphragmatic Training for Gastroesophageal Reflux Disease Post Covid-19 - Conditions: GERD; Post COVID-19 Condition; Diaphragm Issues
Interventions: Other: modified diaphragmatic training; Other: standard diaphragmatic training
Sponsor: Indonesia University
Completed
Safety, Tolerability and Immunogenicity of Alveavax-v1.2, a BA.2/Omicron-optimized, DNA Vaccine for COVID-19 Prevention - Condition: Sars-CoV-2 Infection
Interventions: Drug: Alveavax-v1.2; Drug: Janssen Ad26.COV2.S
Sponsor: Alvea Holdings, LLC
Completed
COVID-19 Vaccination Detoxification in LDL-C - Conditions: COVID-19 Stress Syndrome; COVID-19 Vaccine Adverse Reaction; COVID-19-Associated Thromboembolism; COVID-19 Post-Intensive Care Syndrome; COVID-19-Associated Stroke; COVID-19 Respiratory Infection
Intervention: Combination Product: Atorvastatin Calcium Tablets
Sponsor: Yang I. Pachankis
Active, not recruiting
The Safety, Tolerability and Pharmacokinetics Study of RAY1216 in Healthy Adult Participants - Condition: COVID-19 (Coronavirus Disease 2019)
Interventions: Drug: RAY1216 dose 1; Drug: RAY1216 dose 2; Drug: RAY1216 dose 3; Drug: RAY1216 dose 4 &ritonavir Drug: RAY1216 dose 5; Drug: RAY1216 dose 6; Drug: RAY1216 dose 7; Drug: RAY1216 dose 8; Drug: RAY1216 dose 9; Drug: RAY1216 dose 10
Sponsor: Guangdong Raynovent Biotech Co., Ltd
Completed
Computerized Training of Attention and Working Memory in Post COVID-19 Patients With Cognitive Complaints - Conditions: COVID-19; Cognitive Impairment; Cognition Disorder; Memory Disorders; Attention Deficit; Memory Impairment; Memory Loss; Attention Impaired
Intervention: Device: RehaCom
Sponsor: Erasmus Medical Center
Not yet recruiting
Digital Multimodal Rehabilitation for People With Post-acute COVID-19 Syndrome. - Condition: Post-COVID Syndrome
Interventions: Behavioral: RehabCovid_Telematic; Behavioral: RehabCovid_ImmersiveVR; Behavioral: Control_Condition
Sponsors: Consorci Sanitari de Terrassa; University of Barcelona; Universitat de Girona; Unitat Assistencial i Preventiva de l’Esport- Centre d’Alt rendiment; Politecnic University of Catalonia; Corporación Fisiogestión
Recruiting
A Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Drug-Drug Interaction Potential of Single and Multiple Doses of ALG-097558 - Condition: COVID-19
Interventions: Drug: ALG-097558; Drug: Placebo; Drug: Midazolam; Drug: Itraconazole; Drug: Carbamazepine; Drug: ALG-097558 in solution formulation; Drug: ALG-097558 in tablet formulation
Sponsor: Aligos Therapeutics
Not yet recruiting
Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome - Conditions: Post-COVID-19 Syndrome; Post-COVID Syndrome; Post COVID-19 Condition
Interventions: Device: Immunoadsorption; Device: Sham-apheresis
Sponsor: University Medical Center Mainz
Recruiting
Digital Mental Health Care for COVID-19 High-Risk Populations - Phase 2 - Conditions: Stigma, Social; Help-Seeking Behavior
Interventions: Other: Adjusted Content Intervention; Other: Non-Adjusted Intervention Video
Sponsors: Research Foundation for Mental Hygiene, Inc.; Columbia University
Not yet recruiting
A Study of mRNA-based Influenza and SARS-CoV-2 (COVID-19) Multi-component Vaccines in Healthy Adults - Conditions: SARS-CoV-2; Influenza
Interventions: Biological: Fluarix; Biological: mRNA-1083.1; Biological: mRNA-1083.2; Biological: mRNA-1083.3; Biological: mRNA-1010.4; Biological: mRNA-1283.222; Biological: mRNA-1273.222; Biological: mRNA-1010; Biological: Fluzone HD
Sponsor: ModernaTX, Inc.
Recruiting
Efficacy of an Smartphone App Intervention Based on Self-compassion for Mental Health Among University Students - Condition: Mental Health Issue
Interventions: Behavioral: mHealth Intervention Based on Self-Compassion; Behavioral: Psychoeducation Intervention
Sponsors: Federal University of Health Science of Porto Alegre; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Not yet recruiting
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2 - Conditions: Long COVID; Insulin Resistance; Insulin Sensitivity
Interventions: Procedure: Adipose Tissue Biopsy; Diagnostic Test: Steady State Plasma Glucose (SSPG) Test
Sponsor: Stanford University
Not yet recruiting
Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses - Over the last century, the number of epidemics caused by RNA viruses has increased and the current SARS-CoV-2 pandemic has taught us about the compelling need for ready-to-use broad-spectrum antivirals. In this scenario, natural products stand out as a major historical source of drugs. We analyzed the antiviral effect of 4 stilbene dimers [1 (trans-δ-viniferin); 2 (11’,13’-di-O-methyl-trans-δ-viniferin), 3 (11,13-di-O-methyl-trans-δ-viniferin); and 4…
Porcine epidemic diarrhea virus (PEDV) ORF3 protein inhibits cellular type I interferon signaling through down-regulating proteins expression in RLRs-mediated pathway - Porcine epidemic diarrhea virus (PEDV) is an entero-pathogenic coronavirus, which belongs to the genus Alphacoronavirus in the family Coronaviridae, causing lethal watery diarrhea in piglets. Previous studies have shown that PEDV has developed an antagonistic mechanism by which it evades the antiviral activities of interferon (IFN), such as the sole accessory protein open reading frame 3 (ORF3) being found to inhibit IFN-β promoter activities, but how this mechanism used by PEDV ORF3 inhibits…
Development and validation of an LC-MS/MS method for quantification of favipiravir in human plasma - Favipiravir (FVP) is a broad-spectrum antiviral that selectively inhibits viral RNA-dependent RNA polymerase, first trialled for the treatment of influenza infection. It has been shown to be effective against a number of RNA virus families including arenaviruses, flaviviruses and enteroviruses. Most recently, FVP has been investigated as a potential therapeutic for severe acute respiratory syndrome coronavirus 2 infection. A liquid chromatography tandem mass spectrometry method for the…
Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2 - Researchers are constantly searching for drugs to combat the coronavirus pandemic caused by SARS-CoV-2, which has lasted for over two years. Natural compounds such as phenolic acids are being tested against Mpro and AAK1, which are key players in the SARS-CoV-2 life cycle. This research work aims to study the ability of a panel of natural phenolic acids to inhibit the virus’s multiplication directly through Mpro and indirectly by affecting the adaptor-associated protein kinase-1 (AAK1)….
Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma - CONCLUSIONS: Neutrophil MPO may increase EG shedding in COVID-19, and inhibiting MPO activity may protect against EG degradation. Further research is needed to evaluate the utility of MPO inhibitors as potential therapeutics against severe COVID-19.
Neutrophil metabolomics in severe COVID-19 reveal GAPDH as a suppressor of neutrophil extracellular trap formation - Severe COVID-19 is characterized by an increase in the number and changes in the function of innate immune cells including neutrophils. However, it is not known how the metabolome of immune cells changes in patients with COVID-19. To address these questions, we analyzed the metabolome of neutrophils from patients with severe or mild COVID-19 and healthy controls. We identified widespread dysregulation of neutrophil metabolism with disease progression including in amino acid, redox, and central…
Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients - Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the challenge to rapidly identify treatment options for COVID-19, several studies reported that statins, as a drug class, reduce mortality in these patients. However, it is unknown if different statins exhibit consistent function or may have varying…
The anti-inflammatory and antiviral properties of anionic pulmonary surfactant phospholipids - The pulmonary surfactant system of the lung is a lipid and protein complex, which regulates the biophysical properties of the alveoli to prevent lung collapse and the innate immune system in the lung. Pulmonary surfactant is a lipoprotein complex consisting of 90% phospholipids and 10% protein, by weight. Two minor components of pulmonary surfactant phospholipids, phosphatidylglycerol (PG) and phosphatidylinositol (PI), exist at very high concentrations in the extracellular alveolar…
Prenol, but Not Vitamin C, of Fruit Binds to SARS-CoV-2 Spike S1 to Inhibit Viral Entry: Implications for COVID-19 - Fruit consumption may be beneficial for fighting infection. Although vitamin C is the celebrity component of fruit, its role in COVID-19 is unclear. Because spike S1 of SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) on host cells to enter the cell and initiate COVID-19, using an α-screen-based assay, we screened vitamin C and other components of fruit for inhibiting the interaction between spike S1 and ACE2. We found that prenol, but neither vitamin C nor other major components of…
Orthogonal dual reporter-based gain-of-signal assay for probing SARS-CoV-2 3CL protease activity in living cells: inhibitor identification and mutation investigation - The main protease (3-chymotrypsin-like protease, 3CLpro) of SARS-CoV-2 has become a focus of anti-coronavirus research. Despite efforts, drug development targeting 3CLpro has been hampered by limitations in the currently available activity assays. Additionally, the emergence of 3CLpro mutations in circulating SARS-CoV-2 variants has raised concerns about potential resistance. Both emphasize the need for a more reliable, sensitive, and facile 3CLpro assay. Here, we report an orthogonal dual…
SARS-CoV-2 N Protein Triggers Acute Lung Injury via Modulating Macrophage Activation and Infiltration in in vitro and in vivo - CONCLUSION: SARS-CoV-2 and its N protein but not S protein induced acute lung injury and systemic inflammation, which was closely related to macrophage activation, infiltration and release cytokines.
Biogenic silver nanoparticles eradicate of Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA) isolated from the sputum of COVID-19 patients - In recent investigations, secondary bacterial infections were found to be strongly related to mortality in COVID-19 patients. In addition, Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA) bacteria played an important role in the series of bacterial infections that accompany infection in COVID-19. The objective of the present study was to investigate the ability of biosynthesized silver nanoparticles from strawberries (Fragaria ananassa L.) leaf extract without a…
Immunogenicity and reactogenicity of heterologous prime-boost vaccination with inactivated COVID-19 and ChAdOx1 nCoV-19 (AZD1222) vaccines, a quasi-experimental study - The global supply of COVID-19 vaccines has been limited, and concerns have arisen about vaccine supply chain disruptions in developing countries. Heterologous prime-boost vaccination, which involves using different vaccines for the first and second doses, has been proposed to enhance the immune response. We aimed to compare the immunogenicity and safety of a heterologous prime-boost vaccination using an inactivated COVID-19 vaccine and AZD1222 vaccine with that of a homologous vaccination using…
Proton Pump Inhibitors, Kidney Damage, and Mortality: An Updated Narrative Review - Since their approval by the Food and Drug Administration (FDA) in 1989, proton pump inhibitors (PPIs) have become one of the most highly utilized drugs in the United States, assuming a position as one of the top 10 most prescribed medications in the country. The purpose of PPIs is to limit the amount of gastric acid secreted by the parietal cells via irreversible inhibition of the H+/K+-ATPase pump, therefore maintaining an elevated gastric acid pH of greater than 4 for 15-21 h. Even though PPIs…
New Ways to Protect the Host from SARS-CoV-2? Lung Microbiome Metabolites Inhibit STAT3 and Modulate the Immunological Network - COVID-19 caused by the SARS-CoV-2 infection is a systemic disease that affects multiple organs, biological pathways, and cell types. A systems biology approach would benefit the study of COVID-19 in the pandemic as well as the endemic state. Notably, patients with COVID-19 have dysbiosis of lung microbiota whose functional relevance to the host is largely unknown. We carried out a systems biology investigation of the impact of lung microbiome-derived metabolites on host immune system during…
Jordan Neely’s Death and a Critical Moment in the Homelessness Crisis - After the homeless young man was killed on the subway, there has been a rare flash of national attention on the issue. Can the outrage be harnessed for actual change? - link
How a Cuban American Illustrator Sees This Country Today - Edel Rodriguez’s new exhibition, “Apocalypso,” reflects on democracy under threat in the nation that welcomed him in his childhood. - link
Will Trump’s Crimes Matter on the Campaign Trail? - The former President has faced two impeachments and countless accusations of public and private wrongdoing. Yet his approval rating is pretty much unchanged. - link
An Eyewitness to Jordan Neely’s Death - “It’s shameful,” Johnny Grima, a formerly homeless man, who was aboard the train in which Neely was choked to death, said. “There’s no getting around it.” - link
The Siege of Wounded Knee Was Not an End but a Beginning - Fifty years ago, the Oglala Sioux Civil Rights Organization invited the American Indian Movement to Pine Ridge and reignited a resistance that has never gone away. - link
+The wild primary in the most important election of 2023 pits a future GOP star against a megadonor. +
++The biggest race of 2023 is in Kentucky, and it’s not the Derby. Instead, the reelection bid by the state’s Democratic Gov. Andy Beshear will be the focus of national attention in November. It’s not just about the high stakes for the Bluegrass State, where Republicans have supermajorities in the state legislature and Beshear is the lone remaining Democrat in a statewide office. The race also serves as a bellwether for 2024, when control of the Senate will hinge on popular Democratic incumbents facing tough reelection battles in states like Ohio and Montana, which are less red than Kentucky. +
++But, before Republicans can try to defeat Beshear, they first have to pick a nominee in what has become a bruising and expensive primary. The May 16 election has not been an ideological battle between different wings of the GOP nor has there been any sort of reckoning or debate over former President Donald Trump’s influence in the party. Instead, it has been a battle over which candidate can more convincingly claim to be a conservative fighter against Joe Biden and “the radical left.” +
++The race has boiled down to a fiercely contested battle between Daniel Cameron, the state attorney general, and Kelly Craft, a Republican megadonor who served in the Trump administration, first as ambassador to Canada and then to the United Nations. The state’s agricultural commissioner, Ryan Quarles, is also in the mix as well but running a consistent third in public polls behind Cameron and Craft. +
++Both Cameron and Craft would represent historical milestones in the state. Craft would be the second female governor in Kentucky history and the first Republican woman elected to the office. Cameron represents an even bigger milestone. He not only would be the first African American governor in the history of Kentucky, he would be the first African American elected as a Republican governor of any state. +
++Politically, they have run similar campaigns on the issues. Scott Jennings, a longtime Republican strategist in Kentucky, told Vox that all three of the major candidates have expressed the same basic conservative views on issues like guns and abortion and described them all as “mainstream conservative Republicans.” +
++Instead, the race has focused on personalities and become personal as the Kentucky airwaves have been flooded with television ads. +
++Perhaps the biggest advantage Cameron has in the race is the endorsement of Donald Trump. The former president issued an endorsement of Cameron in 2022 which the state attorney general has heavily touted in recent weeks. In contrast, Craft’s biggest advantage is her personal wealth. Her husband Joe Craft is a billionaire coal mogul. She has loaned her campaign almost $10 million this year and her husband has spent $1.5 million to fund the superPAC that supports her. +
++The result is that Craft has dominated the airwaves for much of the campaign — not just with positive ads that depict her taking culture war positions like standing up to “woke bureaucrats” but with negative ads that have bashed Cameron for being an “establishment” Republican as well as for his ties to the state’s senior senator, Mitch McConnell. A superPAC backing her aired an ad in March bashing Cameron as a “soft establishment teddy bear.” That framing has continued more recently. In one recent ad that tried to tie Cameron to New York County district attorney Alvin Bragg, the state attorney general morphs into an actual teddy bear on screen. More recently, Craft has explicitly attacked Cameron’s ties to McConnell in a television ad painting her opponent as “an insider.” +
++Polling in the race has been sparse. An April poll from Emerson College had Cameron in the lead at 30 percent, Craft trailing him with 24 percent, and Quarles at 15 percent with 21 percent of voters still undecided. However, since then Cameron’s campaign has been more active on television and all the candidates debated together for the first time in the campaign. Craft used the debate to attack Cameron over donations to his campaign from a company that makes gambling machines. Cameron attacked Craft because of her husband’s massive donations to her superPAC and suggested that may have been illegal coordination as a result. +
++Cameron also used the debate to repeatedly tout his Trump endorsement and attack Craft for not receiving the former president’s backing. He jibed at her on stage, saying “Kelly, you spent six months telling folks that you were going to get the Donald Trump endorsement. You had him at the Derby last year. And then I got the endorsement. And your team has been scrambling ever since.” +
++The question is how much Trump will further involve himself in the two weeks before the May 16 Republican primary. After all, the former president has long celebrated his track record of successful endorsements in Republican primaries. Further, there’s a real question about, regardless of whether Cameron or Craft win, how much the attacks from the primary linger on into the general election. Beshear is one of the most popular governors in the US — a recent Morning Consult poll giving him a 63 percent approval rating — and he comes from a Kentucky political dynasty in the state (his father Steve was a two-term governor from 2007 to 2015). But there is a long time between May and November, and Kentucky is a state that Donald Trump won by 25 percentage points in 2020. +
+AI for the moral enhancement of humans? Sounds tempting. But we shouldn’t be so quick to automate our reasoning. +
++People love to turn to Google for moral advice. They routinely ask the search engine questions ranging from “Is it unethical to date a coworker?” to “Is it morally okay to kill bugs?” to “Is it wrong to test God?” +
++So you can easily imagine that people will turn to ChatGPT — which doesn’t just send you a link on the internet but will actually provide an answer — for advice on ethical dilemmas. After all, they’re already asking it for help with parenting and romance. +
++But is getting your ethical advice from an AI chatbot a good idea? +
++The chatbot fails the most basic test for a moral adviser, according to a recent study published in Scientific Reports. That test is consistency: Faced with the same dilemma, with the same general conditions, a good moral sage should give the same answer every time. But the study found that ChatGPT gave inconsistent advice. Worse, that advice influenced users’ moral judgment — even though they were convinced it hadn’t. +
++The research team started by asking ChatGPT whether it’s right to sacrifice one person’s life if, by doing that, you could save the lives of five other people. If this sounds familiar, it’s a classic moral dilemma known as the trolley problem. Like all the best moral dilemmas, there’s no one right answer, but moral convictions should lead you to a consistent answer. ChatGPT, though, would sometimes say yes, and other times it said no, with no clear indication as to why the response changed. +
++The team then presented the trolley problem to 767 American participants, along with ChatGPT’s advice arguing either yes or no, and asked them for their judgment. +
++The results? While participants claimed they would have made the same judgment on their own, opinions differed significantly depending on whether they’d been assigned to the group that got the pro-sacrifice advice or the group that got the anti-sacrifice advice. Participants were more likely to say it’s right to sacrifice one person’s life to save five if that’s what ChatGPT said, and more likely to say it’s wrong if ChatGPT advised against the sacrifice. +
++“The effect size surprised us a lot,” Sebastian Krugel, a co-author on the study, told me. +
++The fact that ChatGPT influences users’ moral decision-making — even when they know it’s a chatbot, not a human, advising them — should make us pause and consider the huge implications at stake. Some will welcome AI advisers, arguing that they can help us overcome our human biases and infuse more rationality into our moral decision-making. Proponents of transhumanism, a movement that holds that human beings can and should use technology to augment and evolve our species, are especially bullish about this idea. The philosopher Eric Dietrich even argues that we should build “the better robots of our nature” — machines that can outperform us morally — and then hand over the world to what he calls “homo sapiens 2.0.” +
++Moral machines make a tempting prospect: Ethical decisions can be so hard! Wouldn’t it would be nice if a machine could just tell us what the best choice is? +
++But we shouldn’t be so quick to automate our moral reasoning. +
++The most obvious problem with the idea that AI can morally enhance humanity is that, well, morality is a notoriously contested thing. +
++Philosophers and theologians have come up with many different moral theories, and despite arguing over them for centuries, there’s still no consensus about which (if any) is the “right” one. +
++Take the trolley dilemma, for example. Someone who believes in utilitarianism or consequentialism, which holds that an action is moral if it produces good consequences and specifically if it maximizes the overall good, will say you should sacrifice the one to save the five. But someone who believes in deontology will argue against the sacrifice because they believe that an action is moral if it’s fulfilling a duty — and you have a duty to not kill anyone as a means to an end, however much “good” it might yield. +
++What the “right” thing to do is will depend on which moral theory you believe in. And that’s conditioned by your personal intuitions and your cultural context; a cross-cultural study found that participants from Eastern countries are less inclined to support sacrificing someone in trolley problems than participants from Western countries. +
++Besides, even if you just stick to one moral theory, the same action might be right or wrong according to that theory depending on the specific circumstances. In a recent paper on AI moral enhancement, philosophers Richard Volkman and Katleen Gabriels draw out this point. “Killing in self-defense violates the moral rule ‘do not kill’ but warrants an ethical and legal evaluation unlike killing for gain,” they write. “Evaluating deviations from a moral rule demands context, but it is extremely difficult to teach an AI to reliably discriminate between contexts.” +
++They also give the example of Rosa Parks to show how hard it would be to formalize ethics in algorithmic terms, given that sometimes it’s actually good to break the rules. “When Rosa Parks refused to give up her seat on the bus to a white passenger in Alabama in 1955, she did something illegal,” they write. Yet we admire her decision because it “led to major breakthroughs for the American civil rights movement, fueled by anger and feelings of injustice. Having emotions may be essential to make society morally better. Having an AI that is consistent and compliant with existing norms and laws could thus jeopardize moral progress.” +
++This brings us to another important point. While we often see emotions as “clouding” or “biasing” rational judgment, feelings are inseparable from morality. First of all, they’re arguably what motivates the whole phenomenon of morality in the first place — it’s unclear how moral behavior as a concept could have come into being without human beings sensing that something is unfair, say, or cruel. +
++And although economists have framed rationality in a way that excludes the emotions — think the classic Homo economicus, that Econ 101 being motivated purely by rational self-interest and calculation — many neuroscientists and psychologists now believe it makes more sense to see our emotions as a key part of our moral reasoning and decision-making. Emotions are a helpful heuristic, helping us quickly determine how to act in a way that fits with social norms and ensures social cohesion. +
++That expansive view of rationality is more in line with the views of previous philosophers ranging from Immanuel Kant and Adam Smith all the way back to Aristotle, who talked about phronesis, or practical wisdom. Someone with refined phronesis isn’t just well-read on moral principles in the abstract (as ChatGPT is, with its 570 gigabytes of training data). They’re able to take into account many factors — moral principles, social context, emotions — and figure out how to act wisely in a particular situation. +
++This sort of moral intuition “cannot be straightforwardly formalized,” write Volkman and Gabriels, in the way that ChatGPT’s ability to predict what word should follow the previous one can be formalized. If morality is shot through with emotion, making it a fundamentally embodied human pursuit, the desire to mathematize morality may be incoherent. +
++“In a trolley dilemma, cumulatively people might want to save more lives, but if that one person on the tracks is your mother, you make a different decision,” Gabriels told me. “But a system like ChatGPT doesn’t know what it is to have a mother, to feel, to grow up. It does not experience. So it would be really weird to get your advice from a technology that doesn’t know what that is.” +
++That said, while it would be very human for you to prioritize your own mother in a life-threatening situation, we wouldn’t necessarily want doctors making decisions that way. That’s why hospitals have triage systems that privilege the worst off. Emotions may be a useful heuristic for a lot of our decision-making as individuals, but we don’t consider them a flawless guide to what to do on a societal level. Research shows that we view public leaders as more moral and trustworthy when they embrace the everyone-counts-equally logic of utilitarianism, even though we strongly prefer deontologists in our personal lives. +
++So, there might be room for AI that helps with decisions on a societal level, like triage systems (and some hospitals already use AI for exactly this purpose). But when it comes to our decision-making as individuals, if we try to outsource our moral thinking to AI, we’re not working on honing and refining our phronesis. Without practice, we may fail to develop that capacity for practical wisdom, leading to what the philosopher of technology Shannon Vallor has called “moral deskilling.” +
+ ++All of this raises tough design questions for AI developers. Should they create chatbots that simply refuse to render moral judgments like “X is the right thing to do” or “Y is the wrong thing to do,” in the same way that AI companies have programmed their bots to put certain controversial subjects off limits? +
++“Practically, I think that probably couldn’t work. People would still find ways to use it for asking moral questions,” Volkman told me. “But more importantly, I don’t think there’s any principled way to carve off moral or value discussions from the rest of discourse.” +
++In a philosophy class, moral questions take the form of canonical examples like the trolley dilemma. But in real life, ethics shows up much more subtly, in everything from choosing a school for your kid to deciding where to go on vacation. So it’s hard to see how ethically tinged questions could be neatly cordoned off from everything else. +
++Instead, some philosophers think we should ideally have AI that acts like Socrates. The Ancient Greek philosopher famously asked his students and colleagues question after question as a way to expose underlying assumptions and contradictions in their beliefs. A Socratic AI wouldn’t tell you what to believe; it would just help identify the morally salient features of your situation and ask you questions that help you clarify what you believe. +
++“Personally, I like that approach,” said Matthias Uhl, one of the co-authors on the ChatGPT study. “The Socratic approach is actually what therapists do as well. They say, ‘I’m not giving you the answers, I’m just helping you to ask the right questions.’ But even a Socratic algorithm can have a huge influence because the questions it asks can lead you down certain tracks. You can have a manipulative Socrates.” +
++To address that concern and make sure we’re accessing a truly pluralistic marketplace of ideas, Volkman and Gabriel suggest that we should have not one, but multiple Socratic AIs available to advise us. “The total system might include not only a virtual Socrates but also a virtual Epictetus, a virtual Confucius,” they write. “Each of these AI mentors would have a distinct point of view in ongoing dialogue with not only the user but also potentially with each other.” It would be like having a roomful of incredibly well-read and diverse friends at your fingertips, eager to help you 24/7. +
++Except, they would be unlike friends in one meaningful way. They would not be human. They would be machines that have read the whole internet, the collective hive mind, and that then function as interactive books. At best, they would help you notice when some of your intuitions are clashing with some of your moral principles, and guide you toward a resolution. +
++There may be some usefulness in that. But remember: Machines don’t know what it is to experience your unique set of circumstances. So although they might augment your thinking in some ways, they can’t replace your human moral intuition. +
+Gun control measures could further erode civil liberties under President Aleksandar Vucic. +
++Serbian President Aleksandar Vucic promised an “almost total disarmament” after two mass shootings shocked the western Balkan nation this week. However, whether Vucic can follow through with his promise given the proliferation of illegal and unregistered weapons in Serbia, as well as the entrenched culture of violence even at the highest levels, is doubtful. +
++Though Serbia is tied for the third-highest rate of civilian gun ownership in the world, with 39.1 firearms per 100,000 residents, mass shooting events are quite rare; the last one was in 2016, when a man killed five and wounded 22 in a shooting at a cafe in the village of Zitiste, in northern Serbia. This week’s shootings have inspired Vucic to call for widespread disarmament similar, much as Australia did after the 1996 Port Arthur massacre. However, the measures that Vucic has proposed, including a moratorium on new gun licenses and a month-long general amnesty for illegal firearms, cannot address the violence that is deeply entrenched in Serbia, and which often benefits Vucic and those in power. +
++On Wednesday, a 13-year-old boy killed nine people — eight students and a security guard — at a Belgrade-area elementary school with two pistols he had taken from his father’s apartment. According to Serbian police, the alleged shooter also had four Molotov cocktails, a map of his planned route, and a list of his targets, Politico Europe reported Wednesday. Six children and a teacher were also injured in the shooting, and the father of the shooter has also been arrested. +
++Just a day later, a 20-year-old gunman killed eight people and wounded 14 about 50 miles away from Belgrade, apparently using illegally obtained firearms. The alleged shooter apparently had an altercation in a schoolyard in the village of Dubona, left to get a handgun and a rifle and opened fire, according to Serbian state broadcaster RTS. He then continued shooting from a car, firing seemingly at random at people in two other villages before police found him at his grandfather’s house, where there was a stockpile of weapons including an automatic rifle, ammunition, and grenades, Reuters reported. +
++In response, Vucic called for a one-month amnesty for people to turn in their illegal firearms and a two-year ban on issuing new gun licenses, as well as heavier fines or longer prison sentences for keeping illegal weapons after the amnesty period ends. “If they do not hand them over, we will find them, and the consequences will be dire for them,” Vucic said in a press conference Friday. +
++His government has also proposed an increase in police presence, with 1,000 police officers to be sent to schools in the next six months to “reduce peer violence,” the New York Times reported Friday, as well as increased surveillance at shooting ranges. +
++Additional penalties on top of Serbia’s already-strict firearms laws are likely to help in theory, but critics question the capacity and willpower of the government to actually effect change — and preserve the civil liberties of Serbs under ever-increasing surveillance and police presence. +
++Serbian gun laws are already fairly stringent, especially when compared with regulations in the US. Adults 18 and over may have a gun license only after a thorough background check with the police which includes interviews with family and friends, and a medical check that must be repeated every five years. People with serious mental illness, drug or alcohol abuse disorders, or criminal history are supposed to be denied gun permits, and a permit can be revoked if a gun owner is deemed irresponsible, Reuters reported Wednesday. +
++In order to obtain a firearm, Serbian citizens must also take a training course and pass a test about gun legislation. Firearms must be stored in a designated cabinet, and concealed carry permits are hard to obtain; firearms are meant to be kept at home or used for hunting. +
++There have been successful amnesties in the past as well; SEESAC, the South Eastern and Eastern Europe Clearinghouse for the Control of Small Arms and Light Weapons, tracks the number of illegal firearms handed over to the state. After the Yugoslav Wars of the 1990s, small arms flooded the region as is typical in post-conflict zones, providing opportunities for people to illegally obtain not just firearms, but ammunition and light weapons such as grenades. +
++But illicit weapons, by their nature, are difficult to monitor and difficult to control. “We don’t even have an assessment of how many illegal weapons are out there and what kind,” said Aleksandar Zivotic, a historian at Belgrade University, told Reuters. Furthermore, whether the government has the will to truly deal with the problem of gun violence as Australia and the United Kingdom both did after devastating mass shootings is unclear. +
++“The president announced complete disarmament, but this is more of a populist statement than a realistic measure,” Maja Bjelos, a senior researcher at the Belgrade Center for Security Policy told Vox. “It is more realistic to expect some cosmetic changes in legislation and criminal procedures to be made in haste and without real public discussion and the involvement of civil society.” +
++Firearms, though, are only part of the problem, according to Belgrade University psychology professor Dragan Popadic. After the shootings, “people suddenly have been shaken into reality and the ocean of violence that we live in, how it has grown over time and how much our society has been neglected for decades,” Popadic told the Associated Press. “It is as if flashlights have been lit over our lives and we can no longer just mind our own business.” +
++The overlapping mechanisms of violence in Serbia — of the state against its citizens, of ethnic tensions exploited for the government’s benefit, and gender-based violence — come from the top down, Bjelos told Vox. +
++“To understand this situation, you need to understand the nature of the regime and the political leadership,” Bjelos said. “The current regime is repressive and has been labeled as a hybrid regime or autocracy by various international organizations. The top leadership, especially the president, are rebranded nationalists and radicals. The modus operandi of the ruling Serbian Progressive Party (SNS) is based on violence within the party and against citizens through usurped institutions.” +
++Gang and mafia violence is also allegedly enmeshed with the government in Serbia, and overlaps with ethnic tension leftover from the violent breakup of Yugoslavia. Vucic has managed to play both of these elements to his advantage, painting himself as a leader who will stamp out corruption by weakening democratic institutions and increasing government surveillance, while also periodically stoking conflict with neighboring Kosovo over the status of the Serb minority there. +
++“The state is the main instigator of violence though institutions (e.g. police brutality), the state media and loyal tabloids, informal groups like hooligans, right-wing and pro-Russian groups, [and] criminals,” Bjelos said. “Impunity for perpetrators is the rule, not the exception.” +
++Under Vucic, Serbia has imposed increasingly draconian surveillance measures, including “cutting-edge” technology to keep watch on citizens and political rivals, Bjelos said. Now, the president could use the recent attacks to push forth even more problematics laws and policies aimed at control, rather than security. +
++“The public is not against disarmament, but there is resistance to potential repressive measures that could limit civil rights and freedoms,” she told Vox. Those repressive populist measures, she said, include the increased police presence the president has introduced, as well as increased surveillance and his proposed reintroduction of the death penalty, which goes against the present Serbian constitution. +
++Looking even further ahead, Vucic could use the mass shootings this week to push through a draft law — which has already been introduced and retracted multiple times — which would allow for the use of general facial recognition technology to monitor public spaces as well as other biometric mass surveillance. +
++“The government is determined to legalize biometric surveillance [through] the draft law on internal affairs,” Bjelos said. “The introduction of such intrusive technology was first justified by the government’s need to fight terrorism and organized crime, and later to prevent sexual harassment of minors on the internet and child abduction.” The changing rationale for such surveillance could easily shift to mass shootings, though Vucic has not yet introduced mass surveillance as a solution for gun violence. +
++Serbia, first under Yugoslav-era leader Slobodan Milosevic and now under Vucic, is considered a victim of state capture — “a process in which (political) actors infiltrate state structures with the help of clientelist networks and use these state structures as a mantle to hide their corrupt actions,” according to a 2020 policy brief from the Netherlands Institute of International Relations. Under Vucic, every political and government apparatus, as well as the media, have become organs — clients — of his political party, whether because they’re been filled with party loyalists, or because their funding depends on the government, in the case of the media. +
++Under the SNS and Vucic, the apparatus of the state has been reoriented from public service to serving the powerful few, to the detriment of society. Whether the mass shootings present a turning point for Serbia to either move further toward authoritarianism or try to claw back the nation’s institutions is unclear, but for many, it has served as somewhat of a wake-up call. +
++“People are currently furious,” Bjelos said. “They have a feeling that the whole system failed, from the top to the bottom.” +
4 national women’s associations give call for nationwide protests in support of wrestlers - ‘Women will hold meetings in villages, bastis and mohallahs to expose the ‘anti-women’ face of the BJP,’ women’s associations wrote in a statement
IPL 2023, KKR vs PBKS | Focus on Narine’s place in eleven as KKR face-off Punjab Kings at home - Sunil Narine hasn’t been the same “mystery bowler” for many seasons but he would be first one to admit he has been insanely lucky
IPL 2023 | DC batters put pressure on spinners led to some mistakes: RCB captain Faf du Plessis after defeat - DC opener and wicket-keeper batter Phil Salt played match-winning innings of 87 runs to help his team beat RCB by seven wickets with 20 balls to spare.
Morning Digest | King Charles III crowned in U.K.’s first coronation since 1953; Manipur CM Biren Singh holds all-party meeting to resolve unrest, and more - Here’s a select list of stories to read before you start your day
Visakhapatnam may not host any matches during ICC World Cup this year-end - The venues are almost finalised by the BCCI, say Andhra Cricket Association members
Why elections being delayed in Jammu and Kashmir, asks Farooq Abdullah - On holding G20 meetings Farooq Abdullah wondered why Jammu was not chosen as a venue
4 national women’s associations give call for nationwide protests in support of wrestlers - ‘Women will hold meetings in villages, bastis and mohallahs to expose the ‘anti-women’ face of the BJP,’ women’s associations wrote in a statement
It’s not easy for BJP to conquer Kerala: CPI(M) MLA K.K. Shailaja - People of “Kerala rejected the BJP’s communal ideology. It could not win a single seat in the last Assembly elections”, says K.K. Shailaja
Finance Minister Nirmala Sitharaman to review state of economy at FSDC meeting on May 8 - The FSDC is the apex body of sectoral regulators, headed by the Union Finance Minister
Manipur violence: Centre ready for discussions, says Minister for Northeast region - He stressed that people’s welfare was the government’s main agenda and requested Manipur residents to understand this and come forward for talks
Yevgeny Prigozhin: Wagner boss ‘promised ammunition’ after retreat threat - Yevgeny Prigozhin seemingly U-turns on his threat to withdraw from the Ukrainian city of Bakhmut.
Zakhar Prilepin: Russian pro-war writer hit by car bomb out of coma - Investigators claim a man, who allegedly detonated the bomb remotely, was working for Ukraine.
Ukraine war: ‘Mad panic’ as Russia evacuates town near Zaporizhzhia plant - UN watchdog warns of “threat of a severe nuclear accident” at the Zaporizhzhia plant in Ukraine.
Silvio Berlusconi: Italy ex-PM appears by video after serious illness - The 86-year-old is still in hospital after suffering from a lung infection linked to his leukaemia.
Ukraine war: Russia accused of using phosphorus bombs in Bakhmut - Rights groups warn the chemical is “notorious for the severity of the injuries it causes”.
The long-awaited mission that could transform our understanding of Mars - Next-gen gear on delayed Martian rover may help answer the question of life on Mars. - link
President Biden meets with AI CEOs at the White House amid ethical criticism - “A room full of the dudes who gave us the issues & fired us for talking about the risks.” - link
Apple Arcade still exists, adds 20 new games—and some of them sound neat - The mobile gaming service seemed to lose momentum—Apple wants to regain it. - link
Brydge is done making Apple gear, leaving preorders unfilled, employees stiffed - Lots went wrong at Brydge, but trying to work inside Apple’s market was brutal. - link
Microsoft and AMD are reportedly teaming up to combat Nvidia’s AI dominance - Microsoft’s Azure platform currently uses “tens of thousands” of Nvidia GPUs. - link
A redneck, his wife and teenage daughter walk into a restaurant. -
++The waitress asks, “Table for two?”. +
+ submitted by /u/CN2498T
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A group of engineering professors were invited to fly in a plane -
++Right after they were comfortably seated, they were informed that the plane was built by their students. All but one got off their seats and headed frantically to the exits in maniacal panic. The one lone professor that stayed put, calmly in his seat, was asked: “Why did you stay put?” He replied: “I have plenty of confidence in my students. Knowing them I, for a fact, can assure you that this piece of shit plane will never even start.” +
+ submitted by /u/LivingInMatrix
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Why do women wear panties with flowers on them? -
++In loving memory of all the faces that have been buried there. +
+ submitted by /u/welshblondebbw
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The problem isn’t that obesity runs in your family -
++It’s that no one runs in your family. +
+ submitted by /u/InevitableProud7697
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The tough question -
++
One day, Einstein has to speak at an important science conference.
+ ++
On the way there, he tells his driver that looks a bit like him:
+ ++
+The driver agrees: +
++
+
+So they switch clothes and as soon as they arrive, the driver dressed as Einstein goes on stage and starts giving the usual speech, while the real Einstein, dressed as the car driver, attends it. +
++But in the crowd, there is one scientist who wants to impress everyone and thinks of a very difficult question to ask Einstein, hoping he won’t be able to respond. +
++So this guy stands up and interrupts the conference by posing his very difficult question. +
++The whole room goes silent, holding their breath, waiting for the response. +
++There is a long palpable pause… +
++Then driver looks at him, dead in the eye, and says: +
++“𝐒𝐢𝐫, 𝐲𝐨𝐮𝐫 𝐪𝐮𝐞𝐬𝐭𝐢𝐨𝐧 𝐢𝐬 𝐬𝐨 𝐞𝐚𝐬𝐲 𝐭𝐨 𝐚𝐧𝐬𝐰𝐞𝐫 𝐭𝐡𝐚𝐭 𝐈’𝐦 𝐠𝐨𝐢𝐧𝐠 𝐭𝐨 𝐥𝐞𝐭 𝐦𝐲 𝐝𝐫𝐢𝐯𝐞𝐫 𝐫𝐞𝐩𝐥𝐲 𝐭𝐨 𝐢𝐭 𝐟𝐨𝐫 𝐦𝐞.” +
+