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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Pandemic and student mental health: A cross-sectional and longitudinal analysis of mental health symptoms amongst university students and young adults after the first cycle of lockdown in the UK</strong> -
<div>
Background Early COVID-19 research suggests a detrimental impact of the initial lockdown on young people’s mental health. Aims We investigated mental health amongst university students and young adults after the first UK lockdown and changes in symptoms over 6 months. Method 895 university students and 547 young adults not in higher education completed an online survey at T1 (July-September 2020). A subset of 201 university students also completed a 6-month follow-up survey at T2 (January-March 2021). Anxiety, depression, insomnia, substance misuse and suicide risk were assessed. Results At T1, ~40%, 25% and 33% of the participants reported moderate-severe anxiety and depression and substance misuse risk; clinically significant insomnia; and suicidal risk. Reduction in anxiety and depression were observed in participants reassessed at T2, but not in insomnia, substance misuse and suicidality. Student and non-student participants reported similar levels of mental health symptoms. Student status was not a significant marker of mental health symptoms, except for lower substance misuse risk. Cross-sectionally, greater symptoms across measures were consistently associated with younger age, pre-existing mental health condition(s), being a carer, worse-off financial status, increased sleep irregularity and difficulty since lockdown. Longitudinally, T2 symptoms were consistently associated with worse-off financial status and increased difficulty sleeping at T1. These associations however attenuated when baseline mental health symptoms were adjusted for in the models. Conclusions Mental health symptoms were prevalent in a large proportion of young people after the first UK lockdown. Risk factors identified may help characterise high-risk groups for enhanced support and inform interventions.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/w5k8e/" target="_blank">Pandemic and student mental health: A cross-sectional and longitudinal analysis of mental health symptoms amongst university students and young adults after the first cycle of lockdown in the UK</a>
</div></li>
<li><strong>The Emotional Anatomy of Lockdown</strong> -
<div>
Throughout the COVID-19 pandemic, policy makers have tried to balance the effectiveness of lockdowns (or stay-at-home orders) with their potential mental health costs. Yet, two years into the pandemic we lack solid evidence about the toll of lockdowns on daily emotional functioning, a key building block of mental health. Using data from two intensive longitudinal studies of 441 Australian participants, sampled at 14,511 occasions during COVID-19 lockdowns in 2021, we compared the degree, persistence, and regulation of people’s emotions on days in and out of lockdown. We found that the emotional toll of lockdowns was relatively mild: In lockdown, people experienced slightly more negative and slightly less positive emotion; returned to a mildly negative emotional state more quickly; and tended to use low-effort emotion regulation strategies. We conclude that people may be quite resilient to the psychological challenges posed by lockdowns.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/hxatc/" target="_blank">The Emotional Anatomy of Lockdown</a>
</div></li>
<li><strong>Assessment of Canadian perinatal mental health services from the perspective of providers: Where can we improve?</strong> -
<div>
Purpose: Perinatal mental health disorders are common, and rates have increased during the COVID-19 pandemic. It is unclear where providers may improve perinatal mental health care, particularly in countries lacking national guidelines, such as Canada. Methods: A cross-sectional survey of perinatal health providers was conducted to describe the landscape of perinatal mental health knowledge, screening, and treatment practices across Canada. Providers were recruited through listservs, social media, and snowball sampling. Participants completed an online survey that assessed their perinatal mental health training, service provision types, their patient wait times, and treatment barriers, and COVID-19 pandemic-related impacts. Results: A total of 435 providers completed the survey, including physicians, midwives, psychologists, social workers, nurses, and allied non-mental health professionals. Most (87.0%) did not have workplace mandated screening for perinatal mental illness but a third (66%) use a validated screening tool. Many (42%) providers stated their patients needed to wait more than 2 months for services. More than half (57.3%) reported they did not receive or were unsure if they received specialized training in perinatal mental health. Most (87.0%) indicated there were cultural, linguistic, and financial barriers to accessing services. Over two-thirds (69.0%) reported the COVID-19 pandemic reduced access to services. Conclusions: Survey findings reveal significant gaps in training, screening tool use, and timely and culturally safe treatment of perinatal mental health concerns. There is critical need for coordinated and nationally mandated perinatal mental health services in Canada to improve care for pregnant and postpartum people.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/cgy8b/" target="_blank">Assessment of Canadian perinatal mental health services from the perspective of providers: Where can we improve?</a>
</div></li>
<li><strong>Health impacts of COVID-19 disruptions to primary cervical screening by time since last screen: A model-based analysis for current and future disruptions</strong> -
<div>
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Background. We evaluated how temporary disruptions to primary cervical cancer (CC) screening services may differentially impact women due to heterogeneity in their screening history and test modality.&lt;br /&gt;&lt;br /&gt;Methods. We used three CC models to project the short- and long-term health impacts assuming an underlying primary screening frequency (i.e., 1, 3, 5, or 10 yearly) under three alternative COVID-19-related screening disruption scenarios (i.e., 1-, 2- or 5-year delay) versus no delay, in the context of both cytology-based and HPV-based screening.&lt;br /&gt;&lt;br /&gt;Results. Models projected a relative increase in symptomatically-detected cancer cases during a 1-year delay period that was 38% higher (Policy1-Cervix), 80% higher (Harvard) and 170% higher (MISCAN-Cervix) for under-screened women whose last cytology screen was 5 years prior to the disruption period compared with guidelines-compliant women (i.e., last screen three years prior to disruption). Over a woman’s lifetime, temporary COVID-19-related delays had less impact on lifetime risk of developing CC than screening frequency and test modality; however, CC risks increased disproportionately the longer time had elapsed since a woman’s last screen at the time of the disruption. Excess risks for a given delay period were generally lower for HPV-based screeners than for cytology-based screeners&lt;br /&gt;&lt;br /&gt;Conclusions. Our independent models predicted that the main drivers of CC risk were screening frequency and screening modality, and the overall impact of disruptions from the pandemic on CC outcomes may be small. However, screening disruptions disproportionately affect under-screened women, underpinning the importance of reaching such women as a critical area of focus, regardless of temporary disruptions.&lt;br /&gt;&lt;br /&gt;Funding. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by funding from the National Cancer Institute (U01CA199334). The contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute. Megan A Smith receives salary support from the National Health and Medical Research Council, Australia (APP1159491) and Cancer Institute NSW (ECF181561). Matejka Rebolj is funded by Cancer Research UK (reference: C8162/A27047). James O’Mahony is funded by Ireland’s Health Research Board (EIA2017054). Karen Canfell receives salary support from the National Health and Medical Research Council, Australia (APP1194679). Emily Burger receives salary support from the Norwegian Cancer Society.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.07.25.22278011v1" target="_blank">Health impacts of COVID-19 disruptions to primary cervical screening by time since last screen: A model-based analysis for current and future disruptions</a>
</div></li>
<li><strong>Transfer learning for Covid-19 detection in medical images</strong> -
<div>
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As of late, the Covid infection 2019 (COVID-19) has caused a pandemic sickness in more than 200 nations, therefore impacting billions of people. To control the spread of the coronavirus, it is crucial to detect infected individuals and ensure their complete isolation to prevent further infection. Chest X-rays and CT-scans have been proven to be very promising as signals of the infection can be clearly shown in lung areas. Transfer learning from ImageNet dataset has become the latent trend in medical imaging applications. However, there are major differences between ImageNet and medical imaging datasets. Therefore, the feasibility of transfer learning in medical applications remains questionable. This paper investigates the performance of five fine-tuned pre-trained models for chest x-rays and CT-scans classification in contrast with a deep CNN model built from scratch. DenseNet121, Resnet-50, Inception v2, Resnet101-V2 and VGG16 are selected and initialized with either random or pre-trained weights to classify augmented images into two classes: Covid and non-Covid. The performance evaluation proves the minuscule impact of training transfer learning models for good quality results, as all CNN models contribute almost equally to the classification and achieve considerable results in terms of precision, accuracy, recall and F1 score.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.07.25.22278017v1" target="_blank">Transfer learning for Covid-19 detection in medical images</a>
</div></li>
<li><strong>McAN: an ultrafast haplotype network construction algorithm</strong> -
<div>
Haplotype network is becoming popular due to its increasing use in analyzing genealogical relationships of closely related genomes. We newly proposed McAN, a minimum-cost arborescence based haplotype network con-struction algorithm, by considering mutation spectrum history (mutations in ancestry haplotype should be contained in descendant haplotype), node size (corresponding to sample count for a given node) and sampling time. McAN is two orders of magnitude faster than the state-of-the-art algorithms, making it suitable for analyzation of massive se-quences. Availability: Source code is written in C/C++ and available at https://github.com/Theory-Lun/McAN and https://ngdc.cncb.ac.cn/biocode/tools/BT007301 under the MIT license. The online web service of McAN is available at https://ngdc.cncb.ac.cn/ncov/online/tool/haplotype. SARS-CoV-2 dataset are available at https://ngdc.cncb.ac.cn/ncov/.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.23.501111v1" target="_blank">McAN: an ultrafast haplotype network construction algorithm</a>
</div></li>
<li><strong>Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2</strong> -
<div>
COVID-19 is a respiratory disease affecting multiple organs including the central nervous system (CNS), with a characteristic loss of smell and taste. Although frequently reported, the neurological symptoms remain enigmatic. There is no consensus on the extent of CNS infection. Here, we derived human induced pluripotent stem cells (hiPSC) into neural progenitor cells (NPCs) and glutamatergic neurons to study their permissiveness to SARS-CoV-2 infection. Flow cytometry and western blot analysis indicated that NPCs and neurons do not express detectable levels of the SARS-CoV-2 receptor ACE2. We thus generated cells expressing ACE2 by lentiviral transduction to analyze in a controlled manner the properties of SARS-CoV-2 infection relative to ACE2 expression. Sensitivity of parental and ACE2 expressing cells was assessed with GFP- or luciferase- carrying pseudoviruses and with authentic SARS-CoV-2 Wuhan, D614G, Alpha or Delta variants. SARS-CoV-2 replication was assessed by microscopy, RT-qPCR and infectivity assays. Pseudoviruses infected only cells overexpressing ACE2. Neurons and NPCs were unable to efficiently replicate SARS-CoV-2, whereas ACE2 overexpressing neurons were highly sensitive to productive infection. Altogether, our results indicate that primary NPCs and glutamatergic neurons remain poorly permissive to SARS-CoV-2 across the SARS-CoV-2 variants inoculated, in the absence of ACE2 expression.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.25.501370v1" target="_blank">Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2</a>
</div></li>
<li><strong>Waning and boosting of functional humoral immunity to SARS-CoV-2</strong> -
<div>
Since the emergence of the SARS-CoV-2 virus, we have witnessed a revolution in vaccine development with the rapid emergence and deployment of both traditional and novel vaccine platforms. The inactivated CoronaVac vaccine and the mRNA-based Pfizer/BNT162b2 vaccine are among the most widely distributed vaccines, both demonstrating high, albeit variable, vaccine effectiveness against severe COVID-19 over time. Beyond the ability of the vaccines to generate neutralizing antibodies, antibodies can attenuate disease via their ability to recruit the cytotoxic and opsinophagocytic functions of the immune response. However, whether Fc-effector functions are induced differentially, wane with different kinetics, and are boostable, remains unknown. Here, using systems serology, we profiled the Fc-effector profiles induced by the CoronaVac and BNT162b2 vaccines, over time. Despite the significantly higher antibody functional responses induced by the BNT162b2 vaccine, CoronaVac responses waned more slowly, albeit still found at levels below those present in the systemic circulation of BNT162b2 immunized individuals. However, mRNA boosting of the CoronaVac vaccine responses resulted in the induction of significantly higher peak antibody functional responses with increased humoral breadth, including to Omicron. Collectively, the data presented here point to striking differences in vaccine platform-induced functional humoral immune responses, that wane with different kinetics, and can be functionally rescued and expanded with boosting.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.22.501163v1" target="_blank">Waning and boosting of functional humoral immunity to SARS-CoV-2</a>
</div></li>
<li><strong>Multi-omics integrated analysis reveals a specific phenotype of CD8+ T cell may contribute to immunothromosis via Th17 response in severe and critical COVID-19</strong> -
<div>
T lymphocyte reduction and immunosenescence frequently occur in severe and critical coronavirus disease 2019 (COVID-19) patients, which may cause immunothrombosis and numerous sequelae. This study integrated analyzed multi-omics data from healthy donors, pneumonia, COVID-19 patients (mild &amp; moderate, severe, and critical), and convalescences, including clinical, laboratory test, PBMC bulk RNA-seq, PBMC scRNA-seq and TCR-seq, BAL scRNA-seq, and lung proteome. We revealed that there are certain associations among T lymphocyte reduction, CD8+ T cell senescence, Th17 immune activation, and immunothrombosis. A specific phenotype (S. P.) CD8+ T cells were identified in severe and critical COVID-19 patients in both PBMC and BAL scRNA-seq, which showed highly TCR homology with terminal effector CD8+ T cells and senescent CD8+ T cells. Pseudotime analysis showed that the S. P. CD8+ T cells were located in the transition trajectory from mild to severe disease. Which may be activated by terminal effector CD8+ T cells or senescent CD8+ T cells, thereby promoting Th17 cell differentiation. This phenomenon was absent in healthy donors, mild and moderate COVID-19 patients, or convalescences. Our findings are an important reference for avoiding the conversion of patients with mild to severe diseases and provide insight into the future prevention and control of COVID-19 and its variants.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2022.07.23.501235v1" target="_blank">Multi-omics integrated analysis reveals a specific phenotype of CD8+ T cell may contribute to immunothromosis via Th17 response in severe and critical COVID-19</a>
</div></li>
<li><strong>The impact of surgical mask-wearing, contact tracing program, and vaccination on COVID-19 transmission in Taiwan from January 2020 to March 2022: a modelling study</strong> -
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The effectiveness of interventions such as public mask-wearing, contact tracing, and vaccination presents an important lesson for control of the further COVID-19 outbreaks without of whole country lockdowns and the restriction of individual movement. We simulated different scenarios of COVID-19 waves in Taiwan from 2020 to the beginning of March 2022 and considered the following interventions: travel restrictions, quarantine of infected individuals, contact tracing, mask-wearing, vaccination, and mass gathering restrictions. We propose an epidemiological compartmental model modified from the susceptible-exposed-infectious-removed (SEIR) model and derive a formula for the basic reproduction number (R0) describing its dependence on all investigated parameters. The simulation results are fitted with the official Taiwanese COVID-19 data. Thus, the results demonstrate that the fast introduction of the interventions and maintaining them at a high level are able the outbreak control without strict lockdowns. By estimation of the R0, it was shown that it is necessary to maintain on high implementation level of both non- and pharmaceutical intervention types to control the COVID-19 transmission. Our results can be useful as advice or recommendation for public health policies, and our model can be applied for other epidemiological simulation studies.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.06.06.22276025v2" target="_blank">The impact of surgical mask-wearing, contact tracing program, and vaccination on COVID-19 transmission in Taiwan from January 2020 to March 2022: a modelling study</a>
</div></li>
<li><strong>Managing bed capacity and timing of interventions: a COVID-19 model considering behavior and underreporting</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Introduction: At the start of the pandemic, the Philippine capital Metro Manila was placed under a strict lockdown termed Enhanced Community Quarantine (ECQ). When ECQ was eased to General Community Quarantine (GCQ) after three months, healthcare systems were soon faced with a surge of COVID-19 cases, putting most facilities at high or critical risk and prompting a return to a stricter policy. Methods: We developed a mathematical model considering behavior changes and underreporting to represent the first major epidemic wave in Metro Manila. Key parameters were fitted to the cumulative cases in the capital from March to September 2020. A bi-objective optimization problem was formulated that allows easing of restrictions at an earlier time and minimizes the necessary additional beds to ensure sufficient capacity in healthcare facilities once ECQ was lifted. Results: If behavior was changed one to four weeks earlier before GCQ, then the cumulative number of cases can be reduced by up to 55% and the peak delayed by up to four weeks. Increasing the reporting ratio during ECQ threefold may increase the reported cases by 23% but can reduce the total cases, including the unreported, by 61% on June 2020. If GCQ began on May 28, 2020, 48 beds should have been added per day to keep the capacity only at high-risk (75% occupancy). Among the optimal solutions, the peak of cases is lowest if ECQ was lifted on May 20, 2020 and with at least 56 additional beds per day. Conclusion: Since infectious diseases are likely to reemerge, the formulated model can be used as a decision support tool to improve existing policies and plan effective strategies that can minimize the socioeconomic impact of strict lockdown measures and ensure adequate healthcare capacity.
</p>
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.03.29.22273148v2" target="_blank">Managing bed capacity and timing of interventions: a COVID-19 model considering behavior and underreporting</a>
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<li><strong>The adverse impact of consecutive COVID-19 waves on mental health</strong> -
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Background: Although several studies documented the impact of COVID-19 on mental health, the long-term effects of COVID-19 on mental health remain unclear. Aims: To examine longitudinal changes in mental health prior to and during the consecutive COVID-19 waves in a well-established probability sample. Method: An online survey was completed by the participants of the COVID-19 add-on study at 4 timepoints (N1=1823, N2=788, N3=532, N4=383): pre-COVID period (2014/2015), 1st COVID-19 wave (April-May, 2020), 2nd COVID-19 wave (August-October, 2020) and 3rd COVID-19 wave (March-April, 2021). Data were collected via a set of validated instruments and analysed using latent growth models. Results: During the pandemic, we observed a significant increase in stress levels (slope=1.127, P&lt;0.001) and depressive symptoms (slope=1.177, P&lt;0.001). The rate of increase in stress levels (cov=2.167, P=0.002), but not in depressive symptoms (cov=0.558, P=0.10), was associated with the pre-pandemic mental health status of the participants. Further analysis revealed two opposing clusters of factors that influenced mental health: loneliness and COVID-19 showed a negative effect on emotionality, while higher resilience acted protectively. A greater increase in stress was observed in women and younger participants. Conclusions: The surge in stress levels and depressive symptoms persisted across all three consecutive COVID-19 waves. This surge is attributable to the effect of several risk factors including the status of mental health prior to the COVID-19 pandemic. Our findings have implications for strategies promoting resilience and addressing loneliness to mitigate the mental health impact of COVID-19 pandemic.
</p>
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<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2021.07.25.21261094v3" target="_blank">The adverse impact of consecutive COVID-19 waves on mental health</a>
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<li><strong>Genomic epidemiology and phylodynamics for county-to-county transmission of SARS-CoV-2 in Minnesota, from 19A to Omicron</strong> -
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SARS-CoV-2 has had an unprecedented impact on human health and highlights the need for genomic epidemiology studies to increase our understanding of the evolution and spread of pathogens and to inform policy decisions. Most efforts have focused on international or country-wide transmission, which are unable to highlight state-wide trends. We sequenced virus genomes from over 22,000 patients tested at Mayo Clinic Laboratories between 2020-2022 and leveraged detailed patient metadata to describe county-to-county spread in Minnesota. Our findings indicate that spread in the state was mostly dominated by viruses from Hennepin County, which contains the largest metropolis. For many counties, we found that state government restrictions eventually led to a decrease in the diversity of circulating viruses from other counties and that their complete removal in May of 2021 saw a drastic revert to levels at or greater than those observed during the months before. We also linked over 14,000 genomes with patient risk characteristics and infection-related phenotypes from the Mayo Clinic electronic health record. We found that the genetic relationship of Omicron viruses was structured by clinical outcomes when stratifying by patient risk factor and variant of concern. However, we were unable to identify nucleotide variants that drove this association.
</p>
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.07.24.22277978v1" target="_blank">Genomic epidemiology and phylodynamics for county-to-county transmission of SARS-CoV-2 in Minnesota, from 19A to Omicron</a>
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<li><strong>Biomarkers and Outcomes in Hospitalized Covid-19 Patients: A Prospective Registry</strong> -
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ABSTRACT Objectives: To determine association of biomarkers high sensitivity C-reactive protein (hsCRP), D-dimer, interleukin-6 (IL-6), lactic dehydrogenase (LDH), ferritin and neutrophil-lymphocyte ratio (NLR) at hospital admission with clinical features and outcomes in Covid-19. Methods: Successive virologically confirmed Covid-19 patients hospitalized from April 2020 to July 2021 were recruited in a prospective registry. Details of clinical presentation, investigations, management and outcomes were recorded. All the biomarkers were divided into tertiles to determine associations with clinical features and outcomes. Numerical data are presented in median and interquartile range (IQR 25-75). Univariate and multivariate (age, sex, risk factor, comorbidity adjusted) odds ratio (OR) and 95% confidence intervals (CI) were calculated to determine association of deaths with each biomarker. Results: We identified 3036 virologically confirmed Covid-19 patients during the study period, 1215 were hospitalized and included in the present study. Men were 70.0%, aged &gt;60y 44.8%, hypertension 44.8% diabetes 39.6% and cardiovascular disease 18.9%. Median symptom duration was 5 days (IQR 4-7) and SpO2 95% (90-97). Total white cell count was 6.9x103/micro-litre, (5.0-9.8), neutrophils 79.2% (68.1-88.2) and lymphocytes 15.8% (8.7-25.5). Medians (IQR) for biomarkers were hsCRP 6.9 mg/dl (2.2-18.9), D-dimer 464 ng/dl (201-982), IL-6 20.1 ng/dl (6.5-60.4), LDH 284 mg/dl (220-396) and ferritin 351 mg/dl (159-676). Oxygen support at admission was in 38.6%, and non-invasive or invasive ventilatory support in 11.0% and 11.6% respectively. 173 (13.9%) patients died and 15 (1.2%) transferred to hospice care. For each biomarker, those in the second and third tertiles, compared to the first, had worse clinical and laboratory abnormalities, and greater oxygen and ventilatory support. Multivariate adjusted OR (95% CI) for deaths in second and third vs first tertiles, respectively, were for hsCRP 2.29(1.14-4.60) and 13.39(7.23-24.80); D-dimer 3.26(1.31-7.05) and 13.89(6.87-28.27); IL-6 2.61(1.31-5.18) and 10.96(5.88-20.43); ferritin 3.19(1.66-6.11) and 9.13(4.97-16.78); LDH 1.85(0.87-3.97) and 10.51(5.41-20.41); and NLR 3.34(1.62-6.89) and 17.52(9.03-34.00) (p&lt;0.001). Conclusions: In Covid-19, high levels of biomarkers- hsCRP, D-dimer, IL-6, LDH, ferritin and NLR are associated with more severe illness and significantly greater in-hospital mortality. NLR, a simple, widely available and inexpensive investigation provides prognostic information similar to the more expensive biomarkers.
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🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.07.20.22277718v1" target="_blank">Biomarkers and Outcomes in Hospitalized Covid-19 Patients: A Prospective Registry</a>
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<li><strong>Reduced Olfactory Bulb Volume Accompanies Smelling Dysfunction After Mild SARS-CoV-2 Infection: The Hamburg City Health Study COVID Program</strong> -
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Background: Despite its high prevalence, the determinants of smelling impairment in COVID-19 remain opaque. Olfactory bulb volumetry has been previously established as a promising surrogate marker of smelling function in multiple otorhinolaryngological diseases. In this work, we aimed to elucidate the correspondence between olfactory bulb volume and the clinical trajectory of COVID-19-related smelling impairment. Therefore, we conducted a large-scale magnetic resonance imaging (MRI)-based investigation of individuals recovered from mainly mild to moderate COVID-19. Methods: Data of 233 COVID-19 convalescents from the Hamburg City Health Study COVID Program were analyzed. Upon recruitment, patients underwent cranial MR imaging and assessment of neuropsychological testing. Automated olfactory bulb volumetry was performed on T2-weighted MR imaging data. Olfactory function was assessed longitudinally after recruitment and at follow-up via a structured questionnaire. Follow-up assessment included quantitative olfactometric testing with Sniffin Sticks. Group comparisons of olfactory bulb volume and olfactometric scores were performed between individuals with and without smelling impairment. The associations of olfactory bulb volume and neuropsychological as well as olfactometric scores were assessed via multiple linear regression. Results: Longitudinal assessment demonstrated a declining prevalence of olfactory dysfunction from 67.6% at acute infection, 21.0% at baseline examination (on average 8.31 +- 2.77 months post infection) and 17.5% at follow-up (21.8 +- 3.61 months post infection). Participants with post-acute olfactory dysfunction had a significantly lower olfactory bulb volume [mm3] at scan-time than normally smelling individuals (mean +- SD, baseline: 40.76 +- 13.08 vs. 46.74 +- 13.66, f=4.07, p=0.046; follow-up: 40.45 +- 12.59 vs. 46.55 +- 13.76, f=4.50, p=0.036). Olfactory bulb volume successfully predicted olfactometric scores at follow-up (r_sp = 0.154, p = 0.025). Performance in neuropsychological testing was not significantly associated with the olfactory bulb volume. Conclusions: Our work demonstrates the association of smelling dysfunction and olfactory bulb integrity in a sample of individuals recovered from mainly mild to moderate COVID-19. Olfactory bulb volume was demonstrably lower in individuals with sustained smelling impairment and predicted smelling function longitudinally. Collectively, our results highlight olfactory bulb volume as a surrogate marker that may inform diagnosis and guide rehabilitation strategies in COVID-19.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2022.07.24.22277973v1" target="_blank">Reduced Olfactory Bulb Volume Accompanies Smelling Dysfunction After Mild SARS-CoV-2 Infection: The Hamburg City Health Study COVID Program</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Puerto Rico COVID-19 Vaccine Uptake Study</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Educational intervention<br/><b>Sponsors</b>:   University of Puerto Rico;   National Institutes of Health (NIH);   National Institute on Minority Health and Health Disparities (NIMHD)<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Learn About a New COVID-19 RNA Vaccine Candidate as a Booster Dose in COVID-19 Vaccine-Experienced Healthy Adults</strong> - <b>Conditions</b>:   SARS-CoV-2 Infection;   COVID-19<br/><b>Interventions</b>:   Biological: BNT162b5 Bivalent (WT/OMI BA.2);   Biological: BNT162b2 Bivalent (WT/OMI BA.1)<br/><b>Sponsors</b>:   BioNTech SE;   Pfizer<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bank of Human Leukocytes From COVID-19 Convalescent Donors With an Anti-SARS-CoV-2 Cellular Immunity</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Other: Generation of a biobank allowing the cryopreservation of leucocytes from COVID19 convalescent donors<br/><b>Sponsor</b>:   Central Hospital, Nancy, France<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Beta-glucans for Hospitalised Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: MC 3x3;   Drug: Placebo<br/><b>Sponsors</b>:   Concentra Educacion e Investigación Biomédica;   Wohlstand Pharmaceutical<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: Molnupiravir 200 mg<br/><b>Sponsors</b>:   University of Witwatersrand, South Africa;   Bill and Melinda Gates Foundation<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An Observer-blind, Cohort Randomized, Exploratory Phase 3 Study to Evaluate the Safety and Immunogenicity of Recombinant Covid-19 Vaccine, mRNA Covid-19 Vaccine and Recombinant SARS-CoV-2 Trimeric S-protein Subunit Vaccine as 4th Dose in Individuals Primed/ Boosted With Various Regimens</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AstraZeneca/Fiocruz;   Biological: Pfizer/Wyeth;   Biological: Clover SCB-2019<br/><b>Sponsors</b>:   D’Or Institute for Research and Education;   Bill and Melinda Gates Foundation;   University of Oxford<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Recombinant COVID-19 Vaccine (Sf9 Cell) as a Booster</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 Vaccine (Sf9 Cell);   Biological: COVID-19 Vaccine (Vero Cell), Inactivated<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity of Recombinant COVID-19 Variant Vaccine (Sf9 Cell) as a Booster</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Infection<br/><b>Interventions</b>:   Biological: Recombinant COVID-19 variant Vaccine (Sf9 Cell);   Biological: COVID-19 Vaccine (Vero Cell), Inactivated;   Biological: mRNA COVID-19 vaccine (Moderna);   Biological: Viral Vector COVID-19 vaccine (AstraZeneca)<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention</strong> - <b>Condition</b>:   Post-acute COVID-19 Syndrome<br/><b>Intervention</b>:   Behavioral: PACS Coping and Recovery (PACS-CR) Intervention<br/><b>Sponsor</b>:   VA Office of Research and Development<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mineralocorticoid Use in COVID-19 Patients</strong> - <b>Conditions</b>:   COVID-19;   ARDS<br/><b>Intervention</b>:   Drug: Fludrocortisone Acetate 0.1 MG<br/><b>Sponsor</b>:   Ain Shams University<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Xanthohumol as an Adjuvant Therapy in Critically Ill COVID-19 Patients</strong> - <b>Condition</b>:   COVID-19 Respiratory Infection<br/><b>Intervention</b>:   Biological: Xanthohumol - prenylated chalcone extracted from female inflorescences of hop cones (Humulus lupus). Hop-RXn™, BioActive-Tech Ltd, Lublin, Poland; http://xanthohumol.com.pl/<br/><b>Sponsor</b>:   Medical University of Lublin<br/><b>Suspended</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Clinical Trial of Immuno-bridging Between Different Manufacture Scales of Recombinant COVID-19 Vaccine (Sf9 Cell)</strong> - <b>Conditions</b>:   COVID-19;   SARS-CoV-2 Pneumonia<br/><b>Intervention</b>:   Biological: Recombinant COVID-19 vaccine (Sf9 cell)<br/><b>Sponsor</b>:   WestVac Biopharma Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Dose Escalation Phase 1 Study Evaluating the Safety and Pharmacokinetics of an Inhaled COVID-19 Inhibitor Delcetravir in Healthy Subjects</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Combination Product: Delcetravir dry powder inhaler<br/><b>Sponsor</b>:   Esfam Biotech Pty Ltd<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Physiotherapy for Persistent COVID-19 Disease Using Aerobic Exercise</strong> - <b>Conditions</b>:   COVID-19;   Genetic Predisposition to Disease<br/><b>Interventions</b>:   Device: Experimental;   Genetic: Control<br/><b>Sponsors</b>:   Universidad Francisco de Vitoria;   Universidad Rey Juan Carlos<br/><b>Completed</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Phase II/III Study of PIKA Recombinant SARS-CoV-2 Vaccine as a Booster Dose.</strong> - <b>Condition</b>:   Covid-19 Vaccine<br/><b>Intervention</b>:   Biological: PIKA COVID-19 vaccine<br/><b>Sponsor</b>:   Yisheng Biopharma (Singapore) Pte. Ltd.<br/><b>Not yet recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2</strong> - Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly on expression of the ACE2 receptor at the muscular injection site. Here, we report that such a viral vector vaccine did not induce protective immunity following intramuscular immunization of K18-hACE2 transgenic mice. However, when the viral vector was trans-complemented with the VSV glycoprotein, intramuscular…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression</strong> - The SARS-CoV-2 frameshifting element (FSE), a highly conserved mRNA region required for correct translation of viral polyproteins, defines an excellent therapeutic target against Covid-19. As discovered by our prior graph-theory analysis with SHAPE experiments, the FSE adopts a heterogeneous, length-dependent conformational landscape consisting of an assumed 3-stem H-type pseudoknot (graph motif 3_6), and two alternative motifs (3_3 and 3_5). Here, for the first time, we build and simulate, by…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding</strong> - Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg) cell counts compared to those with short viral RNA course (SC) in terms of viral load. Longitudinal proteomics and metabolomics analyses of the patient sera uncovered that prolonged viral RNA shedding was associated with inhibition of the liver X…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study</strong> - CONCLUSIONS: Striking antibody evasion manifested by the Omicron variant in patients with ARDs and current vaccine-induced immunity may not confer broad protection from Omicron breakthrough infection, highlighting the need for further research on vaccine effectiveness in patients with immune dysfunctions.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Development and operation of the defence COVID-19 lab as a SARS-CoV-2 diagnostic screening capability for UK military personnel</strong> - CONCLUSIONS: Through a sustained effort and despite various operational issues, the collaboration between Dstl scientific expertise and Defence Pathology clinical expertise provided the UK military with an accredited high-throughput SARS-CoV-2 PCR test capability at the height of the COVID-19 pandemic. The DCL helped facilitate military training and operational deployments contributing to the maintenance of UK military capability. In offering a bespoke capability, including features such as…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation</strong> - Viruses evade the innate immune response by suppressing the production or activity of cytokines such as type I interferons (IFNs). Here we report the discovery of a mechanism by which the SARS-CoV-2 virus coopts an intrinsic cellular machinery to suppress the production of the key immunostimulatory cytokine IFN-β. We reveal that the SARS-CoV-2 encoded nonstructural protein 2 (NSP2) directly interacts with the cellular GIGYF2 protein. This interaction enhances the binding of GIGYF2 to the mRNA…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protease-Responsive Peptide-Conjugated Mitochondrial-Targeting AIEgens for Selective Imaging and Inhibition of SARS-CoV-2-Infected Cells</strong> - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to human health and lacks an effective treatment. There is an urgent need for both real-time tracking and precise treatment of the SARS-CoV-2-infected cells to mitigate and ultimately prevent viral transmission. However, selective triggering and tracking of the therapeutic process in the infected cells remains challenging. Here, we report a main protease (M^(pro))-responsive, mitochondrial-targeting, and…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the dual effects of antiviral drugs on SARS-CoV-2 receptors and the ACE2 receptor using structure-based virtual screening and molecular dynamics simulation</strong> - The use of US FDA-approved drugs is preferred due to the need for lower costs and less time. In in silico medicine, repurposing is a quick and accurate way to screen US FDA-approved medications to find a therapeutic option for COVID-19 infection. Dual inhibitors possess dual inhibitory activity, which may be due to the inhibition of two different enzymes, and are considered better than combination therapy from the developmental and clinical perspectives. In this study, a molecular docking…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting the Receptor-Binding Motif of SARS-CoV-2 with D-Peptides Mimicking the ACE2 Binding Helix: Lessons for Inhibiting Omicron and Future Variants of Concern</strong> - The COVID-19 pandemic continues to spread around the world, with several new variants emerging, particularly those of concern (VOCs). Omicron (B.1.1.529), a recent VOC with many mutations in the spike protein’s receptor-binding domain (RBD), has attracted a great deal of scientific and public interest. We previously developed two D-peptide inhibitors for the infection of the original SARS-CoV-2 and its VOCs, alpha and beta, in vitro. Here, we demonstrated that Covid3 and Covid_extended_1…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Unsymmetrical aromatic disulfides as SARS-CoV-2 Mpro inhibitors: Molecular docking, molecular dynamics, and ADME scoring investigations</strong> - COVID-19 pandemic caused by very severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) agent is an ongoing major global health concern. The disease has caused more than 452 million affected cases and more than 6 million death worldwide. Hence, there is an urgency to search for possible medications and drug treatments. There are no approved drugs available to treat COVID-19 yet, although several vaccine candidates are already available and some of them are listed for emergency use by the…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Severity, predictors and clinical correlates of post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study</strong> - BACKGROUND: Post-COVID syndrome (PCS) is an important sequela of COVID-19, characterised by symptom persistence for &gt;3 months, post-acute symptom development, and worsening of pre-existing comorbidities. The causes and public health impact of PCS are still unclear, not least for the lack of efficient means to assess the presence and severity of PCS.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Targeting ACLY efficiently inhibits SARS-CoV-2 replication</strong> - The Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the biggest public health challenge the world has witnessed in the past decades. SARS-CoV-2 undergoes constant mutations and new variants of concerns (VOCs) with altered transmissibility, virulence, and/or susceptibility to vaccines and therapeutics continue to emerge. Detailed analysis of host factors involved in virus replication may help to identify novel treatment…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation</strong> - COVID-19 which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 Nucleocapsid (N) protein plays a critical role in multiple steps of the viral life cycle and participates in viral replication, transcription, and assembly. The primary roles of N protein are to assemble with genomic RNA into the viral RNA-protein (vRNP) complex and to localize to the replication transcription complexes (RTCs)…</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Friend or Foe? Implication of the autophagy-lysosome pathway in SARS-CoV-2 infection and COVID-19</strong> - There is increasing amount of evidence indicating the close interplays between the replication cycle of SARS-CoV-2 and the autophagy-lysosome pathway in the host cells. While autophagy machinery is known to either assist or inhibit the viral replication process, the reciprocal effects of the SARS-CoV-2 on the autophagy-lysosome pathway have also been increasingly appreciated. More importantly, despite the disappointing results from the clinical trials of chloroquine and hydroxychloroquine in…</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How the Federalist Society Won</strong> - The conservative legal movement was pivotal in getting Roe v. Wade overturned. But does it have any control over what happens next? - <a href="https://www.newyorker.com/news/annals-of-education/how-the-federalist-society-won">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How Much Damage Are the January 6th Hearings Doing to Trump?</strong> - Even as Republican support for another Trump Presidential bid appears to be slipping, he can’t be counted out. - <a href="https://www.newyorker.com/news/our-columnists/how-much-damage-are-the-january-6th-hearings-doing-to-trump">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Agony of an Early Case of Monkeypox</strong> - A friend’s experience revealed a shocking lack of awareness and preparation to counter the spread of the virus in the U.S. - <a href="https://www.newyorker.com/news/dispatch/the-agony-of-an-early-case-of-monkeypox">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Undersea Internet Cables Can Detect Earthquakes—and May Soon Warn of Tsunamis</strong> - A trick of the light is helping scientists turn optical fibres into potential disaster detectors. - <a href="https://www.newyorker.com/science/elements/undersea-internet-cables-can-detect-earthquakes-and-may-soon-warn-of-tsunamis">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Jerome Powell and the Fed Are Still Struggling to Understand a Crazy Economy Hit by the Pandemic and War</strong> - The models that economists have long relied on to analyze inflation have broken down since the coronavirus pandemic began. - <a href="https://www.newyorker.com/news/our-columnists/jerome-powell-and-the-fed-are-still-struggling-to-understand-a-crazy-economy-hit-by-the-pandemic-and-war">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li><strong>Rewatching Gigli in the age of Bennifer’s triumph</strong> -
<figure>
<img alt="A scene from Gigli; Affleck and Lopez sit on a couch together." src="https://cdn.vox-cdn.com/thumbor/-vAX6EDIygpHsM_BZIZs3DT7JmU=/231x0:1599x1026/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71173693/gigli1.0.jpg"/>
<figcaption>
Ben Affleck and Jennifer Lopez met on the set of <em>Gigli</em>, a disaster that still reminds us of how much the movies have changed. | Sony Pictures
</figcaption>
</figure>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Jennifer Lopez and Ben Affleck got married, so I revisited their infamous 2003 flop.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T3j4EK">
The release of the infamous Bennifer train wreck <em>Gigli </em>blipped right by me, a rising college junior, in the doldrums of summer 2003. Since then, thanks to its reputation, it’s existed in my mind only as a shorthand for disaster. I wasn’t in a hurry to verify.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DOqH7A">
It was the Las Vegas nuptials of Ben Affleck and Jennifer Lopez that finally drove me to it. A primer, in case you need it: Affleck and Lopez met on the set of <em>Gigli</em> in 2002 and became an item. They became engaged before the movie was released the following year, then broke up in January 2004 and moved on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2bfv6n">
But last July, in an uneasy pandemic summer, <a href="https://www.vox.com/culture/22629442/bennifer-jennifer-lopez-ben-affleck-reunion-explained">the pair reunited</a>. And though their coupling had provoked a lot of scorn in its early years, now it was an unabashed source of joy for everyone, including them. They finally tied the knot a year later, on July 16, 2022.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8qss0q">
So this week, it was time to watch <em>Gigli</em>.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eNyX78">
Here is the thing: The movie really isn’t <em>quite</em> as bad as its reputation makes it out to be. As others have noted, the infamy of Bennifer contributed mightily to its reception the first time around. (Metacritic rates it as “<a href="https://www.metacritic.com/movie/gigli">overwhelmingly disliked</a>,” at 18/100.) Theaters dropped it like a hot potato; it opened in 2,215 theaters, but dropped by a record-setting 81.9 percent by the second weekend and 97 percent in the third. That means, by its third weekend, it was playing in 73 theaters — a wild bomb for a movie starring not just Affleck and Lopez, who had been on hot streaks, but Christopher Walken and Al Pacino. Al Pacino!
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fqq1R6">
And while a lot of movies from the turn of the millennium feel like they’re from another planet, especially when it comes to misogyny and sexuality, <em>Gigli</em> is from another universe. It’s basically the story of a small-time mobster named Larry Gigli (rhymes with really, played by Affleck) who is hired to kidnap Brian (Justin Bartha), the intellectually disabled younger brother of a district attorney who won’t let a much bigger-time mobster (Pacino) alone. Then another contractor, who introduces herself as Ricki (Lopez), shows up to keep tabs on Larry and an eye on Brian. She and Larry, naturally, end up hooking up.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nT5MTi">
Except Ricki is into women, a fact she makes very clear to Larry from the beginning, making <em>Gigli</em> one of several movies in which a lesbian’s main hurdle to being with a man is that she hasn’t met Ben Affleck yet. (See also <a href="https://www.avclub.com/read-this-why-lesbians-love-and-hate-chasing-amy-20-y-1798260854"><em>Chasing Amy</em></a>.) And Brian’s characterization is — well, it’s a lot. Narratively, there’s really no reason that Brian had to be written as having intellectual disabilities, and not, for instance, as a smart-ass 11-year-old. The main point seems to be that it’s funny to laugh at the silly things he says. It’s … not great.
</p>
<figure class="e-image">
<img alt="The pair in bed." src="https://cdn.vox-cdn.com/thumbor/FCY-nX3AioGcaXYoJiaoI4vrjyY=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23897992/gigli2.jpg"/> <cite>Sony Pictures</cite>
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Lopez and Affleck in <em>Gigli.</em>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KOQnxn">
But, but, but. While <em>Gigli</em> provides plenty to hate on — its tone is all over the place, its score is baffling, and, well, there’s everything mentioned above — I found myself getting oddly nostalgic, and not for ultra-low-rise jeans. Writer and director Martin Brest is no slouch; among his work is the highly decorated <em>Scent of a Woman</em>, shot a decade before <em>Gigli</em>. Affleck, who is a genuinely good director in his own right, has credited his success to his experience watching Brest direct actors on the <em>Gigli </em>set. In <a href="https://www.cinema.com/articles/2349/gigli-production-notes.phtml">the film’s press notes</a>, the cast praised Brest’s direction, with Lainie Kazan, who plays Larry’s mother, saying that “It’s very rare to be directed in such an open, positive way.”
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XcB7pQ">
And notes <a href="https://www.imdb.com/title/tt0299930/alternateversions">on the plot of the original cut of the movie</a>, written up by film critic Michael Dequina following an early screening, show that <em>Gigli</em> was once a darker, weirder, and much more coherent movie. Its key difference from what made it to the screen is that Ricki is only <em>pretending</em> to be a killer. Pacino’s and Walken’s characters, reduced to scene-stealing but somewhat baffling cameos, were far more integrated into the story. The appearance of Ricki’s girlfriend — who in the theatrical version shows up and slits her wrists, then never reappears — suddenly gains meaning: She is the real assassin. Asides that Larry and Ricki make to one another start to make more sense. Even their hookup gains a sort of logic. And in the original version, Larry dies at the end.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4Ya76E">
What happened? <a href="https://www.avclub.com/yes-gigli-really-is-that-bad-1847170362">It seems</a> that the head of Revolution Studios, Joe Roth, was worried after mixed responses in test screenings that the movie wouldn’t do well, and he’d lose his hefty investment in the movie’s co-stars (Lopez made $12 million, Affleck $12.5 million). So though Brest had final cut on the movie, he was strong-armed into recutting it from a weird, offbeat movie about a gangster who wants out into a romantic comedy.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="a4Yg52">
<em>Gigli</em> does not work at all as a rom-com. But knowing this made me wistful for a time when mid-budget rom-coms were the sort of thing you’d make if you needed to earn back your investment. Only in hindsight do we know that 2003 was near the end of the rom-com’s reign; soon they’d start regularly flopping, and now you’re lucky if you can find a watchable new rom-com on streaming services.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="T1dns2">
And yet, it’s fun to see how high the genre was flying at the time. <em>How to Lose a Guy in 10 Days</em> made over $100 million at the box office, a marker of success by any measure, with <em>Something’s Gotta Give</em> hot on its heels at just over $80 million. <em>Love Actually</em>, <em>Intolerable Cruelty</em>, <em>My Big Fat Greek Wedding</em>, and the criminally underrated <em>Down With Love</em> are among <a href="https://www.the-numbers.com/market/2003/genre/Romantic-Comedy">the other rom-coms from that year</a>. This was a time when stars were in mid-budget popcorn movies that now go straight to streaming, and we used to go watch comedies, made from original screenplays, at the theater. It was fun to laugh with other people, and you’d feel good when you went home. Now that sort of movie gets squeezed out entirely by massive-budget franchise films that require diagrams and homework assignments to keep straight.
</p>
<figure class="e-image">
<img alt="Lopez, Affleck, and Justin Bartha in Gigli." src="https://cdn.vox-cdn.com/thumbor/VTp_bj70yn3dJ55tyeFfGcx3JrE=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23897994/gigli3.jpg"/> <cite>Sony Pictures</cite>
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<em>Gigli</em> isn’t good — at all — but it at least seems like it was trying for something.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4s1bbZ">
And then sometimes you’d just discover the movie you’d bought a ticket for was <em>Gigli</em>, and it sucked. Yet even <em>Gigli</em> has its charms. You can feel an independent intelligence — in this case, Brest’s — fighting to get out through the muck and confusion. Bad movies from that era tended, on the whole, to be bad in weird and interesting ways. Like, I don’t know what he was going for here, but you can tell he was going for <em>something</em>. You walk out scratching your head about how it went wrong, but at least it’s clear that <em>this</em> wasn’t really the movie they set out to make.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="B4d9yE">
I thought about this because the week I watched <em>Gigli</em>, I also watched <em>The Gray Man</em>, the new Netflix joint starring Ryan Gosling, Chris Evans, and Ana de Armas (who famously <a href="https://www.glamour.com/story/ben-affleck-and-ana-de-armas-a-complete-relationship-timeline#:~:text=Ben%20Affleck%20and%20Ana%20de%20Armas%20first%20emerged%20as%20a,have%20reportedly%20called%20it%20quits.">dated Affleck for a while, too</a>, though that’s neither here nor there). And it’s bad, but in a deeply boring way. Movies like <em>The Gray Man</em> and the host of other very expensive, very dull films don’t evince some kind of ambition or drive to make a movie, so much as a big chunk of content to send down the tube. (And, in this case, one where the CGI looks truly dreadful.)
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JErK9A">
What was at least potentially fun about <em>Gigli</em> is the way it tried to play with the character of the gangster. Larry doesn’t have a heart of gold, but he does have ambitions to lead a normal life, and in the original version, he gets what he wanted. He’s learned to be a gangster from watching them on TV. Today’s generic bad movie, though, feels like it was created by an AI that’s been fed all the movies in the world and spat out another variation on one.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SFz2If">
All of this should not be taken as an endorsement of <em>Gigli</em>. It’s not even particularly fun to watch, and in our world of unlimited entertainment, who has the time?
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WJahEe">
But I guess I’m glad I watched it, and I suppose I have Bennifer to thank for the reminder that movies don’t always have to be the way they often trend today. If Affleck is grateful for the experience — <a href="https://www.cnn.com/2022/01/12/entertainment/ben-affleck-gigli-jennifer-lopez/index.html">it’s where he met his wife, after all</a> — then who am I to judge?
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="CR9SXs">
Gigli <em>is available to rent or buy on digital platforms.</em>
</p></li>
<li><strong>What if the suburbs were just a first draft?</strong> -
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<img alt="" src="https://cdn.vox-cdn.com/thumbor/r0ac3DCJPANw9hii-dMShSy2UeU=/490x0:3427x2203/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71148817/vox_suburb.0.jpg"/>
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Lia Lao for Vox
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Remote work, the arrival of home-owning millennials, and other forces can be an opportunity to remake them for the better.
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<img alt=" " src="https://cdn.vox-cdn.com/thumbor/YYgW4HsU995yniG4Y5QuEoQvF0Y=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/21899595/VOX_The_Highlight_Box_Logo_Horizontal.png"/>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ZziTnC">
<em>Part of the </em><a href="https://www.vox.com/23178787/highlight-july-2022-issue"><em><strong>July 2022 issue</strong></em></a><em><strong> </strong></em><em>of </em><a href="https://www.vox.com/the-highlight"><em><strong>The Highlight</strong></em></a><em>, our home for ambitious stories that explain our world.</em>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="81lZsm">
The Covid era has produced a number of mixed narratives about housing, land use, and migration patterns. People are <a href="https://www.pewresearch.org/social-trends/2021/12/16/americans-are-less-likely-than-before-covid-19-to-want-to-live-in-cities-more-likely-to-prefer-suburbs/">leaving the city</a>, but also <a href="https://www.wsj.com/articles/these-people-rushed-to-buy-homes-during-covid-now-they-regret-it-11613062856">returning</a>. Remote work is a <a href="https://www.forbes.com/sites/bryanrobinson/2022/02/01/remote-work-is-here-to-stay-and-will-increase-into-2023-experts-say/">historic shift in how Americans work</a>, but <a href="https://www.mckinsey.com/featured-insights/future-of-work/whats-next-for-remote-work-an-analysis-of-2000-tasks-800-jobs-and-nine-countries">50 percent of workers</a> actually can’t work from home. <a href="https://www.washingtonpost.com/nation/interactive/2021/land-development-urban-growth-maps/">Construction is accelerating at the exurban edge</a> of many metro areas — but <a href="https://thedeletedscenes.substack.com/p/what-housing-crisis?s=w">many of the homes going up</a> are dense multifamily structures and mixed-use developments, mimicking what you might find in an urban downtown.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MgPhwH">
Some interesting trends are taking shape in American suburbia. One thing we know, for example, is that the “flight,” or return, to the suburbs is real (though <a href="https://www.bloomberg.com/news/articles/2021-02-02/new-survey-shows-big-cities-aren-t-dead">the death of the city</a> is greatly overstated). We also know that more people are spending more time in the suburbs, and that many who moved there under remote work arrangements are likely to stay. In major American metro areas in East and West Coast cities, suburban prices grew rapidly during the pandemic compared with prices in the urban core, according to one <a href="https://www.brookings.edu/blog/up-front/2022/05/23/did-the-pandemic-advance-new-suburbanization/">Brookings Institution paper</a>. “Further,” it states, “the gap between the two areas — urban and suburban — widened as the pandemic prolonged.” This trend was most pronounced in the Boston and Washington, DC, metro areas; the DC metro area is a premier example of many of these trends, and where they may be going today.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FRzpR4">
“It’s a very strong phenomenon right now, staying within the metro area but moving to a suburban neighborhood rather than central, dense neighborhoods,” <a href="https://www.pewtrusts.org/en/research-and-analysis/blogs/stateline/2022/03/23/the-pandemic-prompted-people-to-move-but-many-didnt-go-far">says economist Stephan Whitaker</a>. It could look like another round of flight from the city. Or what we may be witnessing is a “second draft” of the American suburbs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7pWe0Q">
The suburbs first began to appear in the period after the Civil War, and they grew rapidly with the spread of the electric streetcar in the early 1900s. Many of these very early suburbs retained urban features. When we say “the suburbs” today, however, we often imagine an alternative to, or even a negation of, the city.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QIA2sK">
The suburbs exploded when post-World War II America needed lots of housing cheap and fast — modern suburbia was essentially a housing program. Suburbs received another influx in the era of “white flight” and racial tensions in American cities in the 1960s and 1970s. That era also saw a wave of downzonings across the country, ensuring that most new development would be single-family or, at most, low-rise multifamily.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2JG7IG">
The suburbs are still growing, both getting denser and sprawling outward. Some of this follows the rise of remote work, but much of it is also driven not by would-be residents’ desire to leave the city but by <a href="https://nypost.com/2022/04/28/record-high-rents-are-driving-people-back-out-of-nyc/">sky-high </a>urban housing prices.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="fR7bbw">
The demand for something <em>like</em> urban living is real. Even at the outer edges of growing metro areas, mixed-use walkable developments pop up alongside familiar subdivisions and McMansions. “Mixed-use centers—often in suburban locations—continue to be built from the ground up in many communities across the US,” <a href="https://www.cnu.org/publicsquare/2019/12/11/designing-and-building-mixed-use-centers-suburbs">wrote the Congress for the New Urbanism</a> in 2019.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DYY9rC">
As more immigrants and millennials become suburbanites, and as Covid and remote work give the suburbs another growth spurt, they are evolving into something different. Between 2019 and 2020, <a href="https://www.ksat.com/news/local/2020/11/23/research-shows-millennials-are-leaving-cities-and-buying-homes-in-suburbs/">the share of millennials who live in suburbs increased by 4 percentage points</a>; and in 2014, <a href="https://www.theatlantic.com/politics/archive/2014/12/americas-immigrants-are-moving-to-the-suburbs/431748/">more than 60 percent of immigrants lived in suburbs</a>, up from just over half in 2000.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mQs41G">
Many communities that were once white, exclusionary, and car-dependent are today diverse and evolving places, still distinct from the big city but just as distinct from their own “first draft” more than a half-century ago.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="37uNP7">
Consider the <a href="https://www.nytimes.com/2018/12/19/realestate/levittown-ny-the-original-starter-community.html">Levitt houses of Long Island</a> — a sort of ur-suburbia — very few of which still look like they did when they were built. Most have been modified, renovated, and expanded over the years; what was once a standard product has diverged in thousands of ways. (Some are even under-the-table duplexes, and it seems to work just fine.)
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SkzdRz">
Levittown was the first draft, not the final or perpetual state. The distributed, incremental evolution we can observe with these decades-old tract houses is coming to fruition in the suburbs, writ large.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="j1b2P9">
The ongoing diversification of the suburbs is coinciding with the appearance of New Urbanist, mixed-use development there, and the renewed interest in suburban living following the pandemic. The makings of a suburban transformation are here.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t4QgRR">
It’s likely that the average person isn’t necessarily thinking in terms of urban design, or density, or mixed-use development. They simply have, as Maryland-based urban planner Dan Reed told me, “the desire to be near things.” Even before the pandemic, Business Insider listed the 25 fastest-appreciating suburbs in the United States — a list that included places as different as <a href="https://www.businessinsider.com/suburbs-where-home-values-are-increasing-fastest-america-ranked-2019-7#lynnwood-washington-over-the-past-five-years-the-median-home-value-in-lynnwood-has-increased-by-663-1">exurban, car-dependent DeSoto, Texas, and New Jersey’s more urban Union City</a>. It includes several suburbs in Florida and Washington, but also a couple in seemingly less likely Michigan.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rxeqAs">
This desire to be near things is as likely to lure millennials leaving the city to seek less expensive housing as it is immigrants coming from countries with more traditional urbanism, and remote workers looking for amenities they used to find near their urban offices. What makes suburbs desirable for many people today is not what Americans traditionally associate with “the suburbs.” It’s vibrant dining scenes — according to the New York Times, <a href="https://www.nytimes.com/2022/01/18/dining/best-restaurants-suburbs.html">some of the best in the country</a> — nightclubs, taller buildings, and walkable developments.
</p>
<hr class="p-entry-hr" id="EQkV9Z"/>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="sXiEk4">
Even before the pandemic, these trends were intersecting. The DC metro area, where I live, is one of the finest examples. But it is not the only one.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tJmZVC">
Edison, New Jersey, for example, boasts a large Indian American population, and its unassuming Oak Tree Road corridor is one of America’s largest concentrations of Indian restaurants and businesses. In suburban Atlanta, Georgia, <a href="https://www.atlantamagazine.com/dining-news/buford-highways-accidental-advocate/">the Buford Highway commercial strip</a> is a lively international neighborhood inhabiting what might otherwise have aged into a worn-out postwar suburban development.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="luzk0u">
In my own region, there’s a 1950s strip plaza noted for its concentration of Bangladeshi and other South Asian shops and restaurants, and an even larger shopping center <a href="https://www.strongtowns.org/journal/2022/1/18/eden-center-is-this-strip-mall-paradise">boasting one of the country’s largest concentrations of Vietnamese restaurants and businesses</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ynLDmp">
All of these places serve as community fixtures for whichever immigrant communities live and shop there, and that’s how they first arose. Over time, they’ve also become local attractions, part of the appeal for other suburbanites, too. Lifestyle magazines, geared toward an upper-middle-class readership, frequently feature these diverse suburban community centers in restaurant reviews and “things to see” lists. New Jersey Monthly, for example, heralds <a href="https://njmonthly.com/articles/eat-drink/oak-tree-road-street-of-dreams/">Oak Tree Road as a dream for Indian food lovers</a>; Food &amp; Wine Magazine <a href="https://www.foodandwine.com/travel/restaurants/buford-highway-atlanta-best-restaurants">dubs Atlanta’s Buford Highway corridor</a> “one of the South’s most fascinating places.” <a href="https://www.arlingtonmagazine.com/eden-center-falls-church/">Ditto for Northern Virginia’s Eden Center</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VTEDxm">
Unlike urban immigrant neighborhoods of the 19th and 20th centuries, many of these communities inhabit what are now older suburban landscapes. Annandale, a Fairfax County, Virginia, community of largely postwar vintage, is the DC area’s Koreatown. In Maryland’s DC suburbs, many aging strip plazas are filled with African and Latino small businesses. Many of us have seen an urban food hall inhabiting an old factory, with exposed brick and Edison bulbs; Annandale <a href="https://www.washingtonian.com/2019/09/10/arturo-mei-the-block-virginia-food-hall/">has a food hall, too</a>, founded and owned by Asian Americans, but it inhabits an old strip mall that was all but abandoned after the closure of a Kmart.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WRNX9S">
That’s the essence of the subtle but real suburban transformation. These days, they serve immigrants but also attract tourists and other visitors, and serve as places of cultural interest for residents in general.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SEHI4P">
Reed says he thinks people are looking for something that “feels enough like a place.” That can be something like an upscale mixed-use town center; it can be informal arrangements like food trucks, barbecue smokers, and coffee shops setting up in disused suburban parking lots. Some are disused because they were park-and-rides; others sit in neighborhoods that now tilt working-class, where fewer households own two cars. What these places aren’t, any longer, is that flight-from-the-city first draft.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="30aWfZ">
If a “second draft” of the suburbs is now being written — at least in some of America’s growing and expensive metro areas — what might it actually look like? On that note, back to the DC suburbs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IRItYu">
Rockville, Maryland, a suburban community about half an hour from DC by car, didn’t always look like standard suburban sprawl. In the early 20th century, it <a href="https://peerlessrockville.org/historic-rockville/rockvilles-past/the-trolley-era-in-rockville-1900-1935/">had trolley service into the urban core</a>. The trolleys completed “24 trips a day between 6:30 a.m. and 12:30 a.m.,” not unlike the region’s subway service today. The trolleys were scrapped in 1935, and it was not until 1984 that the Metro system was extended out to Rockville.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="X3j4EN">
Looking back, scrapping the trolleys wasn’t Rockville’s only mistake. In 1962, the town embraced urban renewal and leveled nearly all of its original downtown, wiping not only the buildings but even the street grid off the map. In its place, they built a mall and office complex. That period, from 1935 to 1984, and especially from 1962 to 1984 — no rail, no downtown — typifies what we often mean by “suburban.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="geofL5">
Today, Rockville is very different, and in some ways it resembles its original state more than its “suburban interlude.” Rockville is widely considered to be the region’s main Chinatown, with a population that is about 20 percent Asian American, and an array of restaurants, Chinese newspapers, and other businesses that serve a predominantly Chinese customer base. In the 2000s, the mall that stood atop the old “downtown” was demolished, and a “town center” with gridded streets was built in its place. For curmudgeons or NIMBYs who think these trends are altering Rockville’s character, they just need to look further back for their baseline. The changes in Rockville aren’t turning it into something it <em>isn’t</em>; they’re turning it into something it used to be, and continuing a process artificially arrested by the suburban era.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tddV8u">
It’s a matter of some debate whether suburbs were “supposed” to become encased in amber, built at once <a href="https://www.strongtowns.org/journal/2017/6/14/the-end-of-incrementalism">“to a finished state”</a> and barely changing after that, their land use destined to end up at the mercy of NIMBYism. Zoning codes were not really meant to be perpetual; master plans were supposed to guide their evolution over the decades, planning for and accommodating growth. But in most places, that did not happen: Most growth was sprawling and horizontal, and many suburban landscapes still appear essentially unchanged from when they were built in the midcentury.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oMAMsf">
But allowing these places to change, and embracing the change already occurring, doesn’t mean wiping them off the map — hopefully, we learned that from our urban renewal mistakes. Their next chapter is waiting to be written; maybe this time, we’ll understand that the writing is never done.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qpIRuM">
<em>Addison Del Mastro writes on urbanism and cultural history. He’s also the author </em><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__thedeletedscenes.substack.com_&amp;d=DwMFaQ&amp;c=7MSjEE-cVgLCRHxk1P5PWg&amp;r=Rg_frVECyHq8RLGpsvHBW3D76DIRpCQrSH_yE2X1iQg&amp;m=2hPu9pzb7IoPVuWmJVCfDBHVWx1ePIG25y4fDynXxgO35cHfaU88S1Gi1YaDc2HK&amp;s=Zig9VPS7LuZCO_JboAZOI6fVcMOYhwf3VHJSoan4Qs0&amp;e="><em>The Deleted Scenes</em></a><em> on Substack. </em>
</p>
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<div id="123QmI">
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<li><strong>A Black rodeo rewrites the story of the West</strong> -
<figure>
<img alt="Two riders on horseback with print skirts that extend over the rumps of their horses." src="https://cdn.vox-cdn.com/thumbor/desKlE7bNqSqdWEBdirDx-QLVNI=/0x0:1635x1226/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/71148820/B0000910_exclusive.0.jpg"/>
<figcaption>
Juanita Brown, left, and her granddaughter Iyauna Austin don African print skirts in this 2018 photo. The women wore the skirts for the Black Cowboy Parade and later for the Bill Pickett Invitational Rodeo. “They get to see the hard work you put into your horse to make you look good,” Austin told photographer Gabriela Hasbun. “What you wear also helps your horse.” | Photos by Gabriela Hasbun
</figcaption>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
At the Bill Pickett Invitational Rodeo, Black riders and fans bring a sense of swaggering cool to a culture overlooked by the history books.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2fbhqA">
<em>Part of the </em><a href="https://www.vox.com/23178787/highlight-july-2022-issue"><em><strong>July 2022 issue</strong></em></a><em><strong> </strong></em><em>of </em><a href="https://www.vox.com/the-highlight"><em><strong>The Highlight</strong></em></a><em>, our home for ambitious stories that explain our world.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bTHZHC">
The tale of Bill Pickett, a legendary Black cowboy often barred from competing in largely white rodeos, stuck with Lu Vason. A Denver entrepreneur, Vason had first heard of Pickett — who invented the skill known as “bulldogging” to subdue wayward steers — on a chance visit to Denver’s Black American West Museum.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4gd70N">
Historians estimate that <a href="https://www.smithsonianmag.com/history/lesser-known-history-african-american-cowboys-180962144/">one-quarter</a> of American cowboys were Black, but Vason felt that Pickett and other turn-of-the-century Black figures who were part of the fabric of America’s Western expansion had been all but written out of history books. So, in 1984, Vason started the Bill Pickett Invitational Rodeo, a Black rodeo that he saw as a way to challenge and broaden the narrow lore of the West. Today, the rodeo crisscrosses the US, serving as an inclusive gathering place for Black rodeo fans and budding Black rodeo stars alike.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4mxMaQ">
San Francisco-based photographer Gabriela Hasbun was invited to tag along with friends to a Bill Pickett rodeo stop in 2007 at Rowell Ranch Rodeo, east of Oakland, California. Captivated, she returned a year later with a medium-format camera and a bag of film. For a decade, Hasbun captured what she saw: an age-old tradition infused with pride, highly modern fashion, and personal expression. A Bill Pickett rodeo is a place you might meet a horse named after <a href="https://dapperdanofharlem.com/">Dapper Dan</a>, catch a glimpse of a saddle emblazoned with the Louis Vuitton logo and artisan metalwork, or marvel at all the hair (horse), the nails (human), and the swagger (everyone).
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kU6QI3">
Like Vason, Hasbun didn’t think the community was getting its due. “I couldn’t believe there was this huge Black community — very family-driven — having a wholesome event, and the media was overlooking it,” she told Vox.
</p>
<div class="p-fullbleed-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/2nkWra970bWxN1kL-jdHhFIXJtU=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23865595/19_2019_07_13_BillPickett_0512.jpg"/>
<figcaption>
Prince Damons and cowboys Sam Styles and Jonathan Higgenbotham parade through the grand entry of the Bill Pickett Invitational Rodeo in 2019. The touring rodeo, which launched in 1984 in Denver, attracts fans across the nation. “These kids are cool. They look cool,” says Hasbun. “They reek of cool. It’s this crazy attraction they have with the whole sport.”
</figcaption>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="72buyb">
“These kids are cool. They look cool,” says Hasbun. “They reek of cool. It’s this crazy attraction they have with the whole sport.”
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/2Q9tHZbwSm6KzvDLwXEZslMEEiw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23875393/01_2019_07_13_BillPickett_767.jpg"/>
<figcaption>
Rodeo attendee Deidre Webb of Washington state shows off her manicure at the California Bill Pickett rodeo in 2019. “My first day there, Pam let me ride her horse, and she had one of the other cowgirls walk me around that whole big back area on the horse,” she told Hasbun. She has since become a rodeo regular.
</figcaption>
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<img alt=" " src="https://cdn.vox-cdn.com/thumbor/Kqk2xnQcdCrsoVs4Lc0oPFamVGw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23865667/2018_07_14_BillPickettRodeo_5628__2.jpg"/>
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<img alt=" " src="https://cdn.vox-cdn.com/thumbor/g5YAzXuYM_r3y7Pz1AKD-msko9A=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23884168/18_BillPickett_4155_35_RET.jpeg"/>
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<p class="caption" data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
From top left, an attendee of the rodeo shows off his style in this undated photo; longtime rider and rancher known as Mr. Theus, for whom decking out himself and his horse — he has saddles, he says, by the saddle maker for Roy Rogers and Gene Autry — has earned him many fans at the rodeo.<em> </em>Bottom, from left: Harold Williams Jr. (in chaps) and Lindon Demery, two junior rodeo champions, captured in 2018; and Adrian Vance and Ronnie Franks, left, in red, who are mother-daughter cowgirls from Atlanta. The two sit with other contestants to watch the races in this 2008 photo. Many cowgirls compete in the rodeo’s barrel-racing competition.
</p>
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</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vlpoQ2">
Hasbun’s new book, <em>The New Black West</em>, captures the horsey set as a colorful whirl of activity and flash amid the faded, sun-washed backdrop of the dusty beiges of the drought-ridden country and the denim blue of the clear sky.
</p>
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/24P2Q0MCQCI_JuEO2aOj0vYTeUg=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23875709/60_BillPickett_2643_28x.jpg"/>
<figcaption>
Ronald Jennings III, a Texas teenager active in the rodeo, visits the Bay Area Rodeo in 2019 with his family. “I had to take care of all the steers and bulls at the rodeo and on my parents’ ranch,” he told Hasbun. “Having horses is a big responsibility.”
</figcaption>
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<div class="p-fullbleed-block">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/iZfmShhC2J9FTHEp9LAadfmge8k=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23875378/12_BillPickett_4157_f17.jpg"/>
<figcaption>
Joseph “Dugga” Matthews (far right), a horse trainer and veterinarian, is pictured with a group of riders from Stockton, California, in this 2008 photo. The parking lot, Hasbun writes, regularly turns into a social scene, allowing riders to interact, and fans to try riding — sometimes for the first time.
</figcaption>
</figure>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8MHgGO">
Images like her striking shot of Juanita Brown and her granddaughter Iyauna Austin atop their horses, with their African print skirts draped across their horses, and their dusty, worn lace-up boots peeking out from the stirrups, Hasbun believes, will help rewrite the story of the West, and of cowboy culture.
</p>
<div class="c-wide-block">
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<img alt=" " src="https://cdn.vox-cdn.com/thumbor/p_7PL2mSjEd2Mc_07xVnRmYqVHE=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23884178/38_2018_07_01_Damons_1705__8.jpeg"/>
<figcaption>
Prince Damons, a recording artist, tends his horse, Jesse James. “I know pretty much every time I get on my horse’s back, I’m breaking the stereotype out on the trails,” he told Hasbun.
</figcaption>
</figure>
</div>
<div class="c-image-grid__item">
<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/_l93bN1A41Q2tGyJbnWAwgrhWYs=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23884182/37_2018_07_01_Damons_1705__9.jpeg"/>
<figcaption>
A detail of Prince Damons with Jesse James. “I see people and a lot of them give me the same kind of look,” he told Hasbun. “Just like, ‘Oh, look! There’s a real-life Black cowboy?! I can’t believe it.’”
</figcaption>
</figure>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="InThNf">
“No one,” Hasbun says, “can ignore a Black woman on a horse.”
</p>
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<figure class="e-image">
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/BKr3q65W_SKKxW04PD0X_p3Cu68=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/23875420/16_2018_07_14_BillPickettRodeo_5609.jpg"/>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="zZqEVE">
<em>The </em><a href="https://www.chroniclebooks.com/products/the-new-black-west-hc">New Black West</a><em> was published by Chronicle Books in 2022. Gabriela Hasbun is a photographer specializing in portraits; her work highlights marginalized and under-explored communities. </em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8N2GvV">
<em>Lavanya Ramanathan is the editor of the Highlight. </em>
</p>
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</div></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kerala’s boat race season begins: Here is a list of the main races, their dates and locations</strong> - A series of water spectacles awaits the viewers in Kerala this season</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Qatar World Cup | 24 teams to be based within 10km radius</strong> - Unlike in previous editions of the FIFA World Cup, all teams in Qatar will stay in the same hotel and use the same training base throughout the tournament</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rally of Coimbatore: JK Tyre fields power-packed line-up</strong> - Gaurav Gill &amp; Co. will be looking to make amends for a disappointing first round</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Leopard Rock shines</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cristiano Ronaldo set for talks with Manchester United on arrival at Carrington training base</strong> - Cristiano Ronaldo has yet to start preseason training with Manchester United and is set to hold talks with recently hired manager Erik ten Hag</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kumarakom boat tragedy memorial in Kerala in neglect</strong> - Officials attribute the apathy to dispute between various departments</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Army pays tribute to Kargil hero</strong> - Underwater portrait of Captain Vikram Batra installed</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Kerala’s boat race season begins: Here is a list of the main races, their dates and locations</strong> - A series of water spectacles awaits the viewers in Kerala this season</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Rain pounds and floods State capital overnight</strong> - Most areas in Hyderabad received copious rainfall</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Andhra Pradesh CM to visit flood-hit hamlets on July 27</strong> -</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>EU agrees to cut gas use over Russia supply fears</strong> - EU members agree to voluntarily reduce gas use by 15%, but some members can seek exemptions.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Czech forest fire smoke drifts across country</strong> - People have been told to keep windows closed as the smell of smoke spreads to many areas.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Freya the 600kg walrus causes a stir in Norway</strong> - The young female marine mammal has been spotted clambering onto boats to doze in the summer sun.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Basketball player’s missing wheelchair found in Amsterdam</strong> - Basketball player Jess Whyte’s £7,000 chair was lost after she flew from East Midlands Airport.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UK to host next year’s Eurovision Song Contest</strong> - Ukraine expresses its gratitude amid promises the show will celebrate the winning country.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New hypothesis emerges to explain mysterious hepatitis cases in kids</strong> - Two viruses and a genetic pre-disposition linked to the puzzling condition in preliminary data. - <a href="https://arstechnica.com/?p=1869296">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Climate change is turning up the heat on lakes</strong> - Climate change is wreaking havoc on the planet’s 117 million lakes - <a href="https://arstechnica.com/?p=1869273">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NFL+ is here, but it’s probably not what you’re looking for</strong> - NFL streaming is still mired in a mess of tangled platform agreements. - <a href="https://arstechnica.com/?p=1869117">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>2K relents to fans, turns servers back on for abandoned “4v1” online game</strong> - Online-only <em>Evolve</em> gets second lease on life, complete with matchmaking. - <a href="https://arstechnica.com/?p=1869239">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Motherboards are already supporting unreleased, unannounced 13th-gen Intel CPUs</strong> - The first “Raptor Lake” processors are expected sometime this fall. - <a href="https://arstechnica.com/?p=1869160">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
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<li><strong>A man at my wife’s workplace has been sexually harassing her, but honestly I feel like it’s her fault.</strong> - <!-- SC_OFF -->
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She’s the one who chose to work from home, and she knows how I feel about dat ass.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/JoeyRobot"> /u/JoeyRobot </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w84mhr/a_man_at_my_wifes_workplace_has_been_sexually/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w84mhr/a_man_at_my_wifes_workplace_has_been_sexually/">[comments]</a></span></p></li>
<li><strong>Bob returned from a Doctor’s visit and told his wife Alma that the Doctor said he only had 24 hours to live</strong> - <!-- SC_OFF -->
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<em>Bob returned from a Doctor’s visit and told his wife Alma that the Doctor said he only had 24 hours to live.</em>
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Wiping away her tears, he asked her to make love with him. Of course she agreed and they made passionate love.
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Six hours later, Bob went to her again, and said, “Honey, now I only have 18 hours left to live. Maybe we could make love again?” Alma agreed and again they made love.
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Later, Bob was getting into bed when he realized he now had only eight hours of life left.
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He touched Alma’s shoulder and said, “Honey Please? Just one more time before I die.” She agreed, then afterwards she rolled over and fell asleep.
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Bob, however, heard the clock ticking in his head, and he tossed and turned until he was down to only four more hours.
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He tapped his wife on the shoulder to wake her up. “Honey, I only have four hours left! Could we…?”
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His wife sat up abruptly, turned to him and said :
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<em>"Listen Bob, I have to get up in the morning for your funeral &amp; You don’t have to get up !!!</em>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/confusedvagabond"> /u/confusedvagabond </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w7wdv9/bob_returned_from_a_doctors_visit_and_told_his/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w7wdv9/bob_returned_from_a_doctors_visit_and_told_his/">[comments]</a></span></p></li>
<li><strong>What starts with a P and ends in an S? (hint: men have it and women want it)</strong> - <!-- SC_OFF -->
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Pockets
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/moistIam"> /u/moistIam </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w7xukm/what_starts_with_a_p_and_ends_in_an_s_hint_men/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w7xukm/what_starts_with_a_p_and_ends_in_an_s_hint_men/">[comments]</a></span></p></li>
<li><strong>A reddit moderator walks into a bar</strong> - <!-- SC_OFF -->
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[removed]
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/encrustedpeanut43"> /u/encrustedpeanut43 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w8ff0y/a_reddit_moderator_walks_into_a_bar/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w8ff0y/a_reddit_moderator_walks_into_a_bar/">[comments]</a></span></p></li>
<li><strong>Because the punchline gets spoiled early.</strong> - <!-- SC_OFF -->
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Why is this time travel joke not funny?
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Winkelkater"> /u/Winkelkater </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/w7zouv/because_the_punchline_gets_spoiled_early/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/w7zouv/because_the_punchline_gets_spoiled_early/">[comments]</a></span></p></li>
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