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+ + + ++The immune system plays a crucial role in many human diseases. In this context, genome-wide association studies (GWAS) offer valuable insights to elucidate the role of immunity in health and disease. The present multi-omics study aimed to identify genetic determinants of immune cell type distributions in the blood of healthy individuals and to assess whether the distributions of these cells may play a role for autoimmune and COVID-19 disease risk. To this end, the frequencies of different immune cells in 483 healthy individuals from the Berlin Aging Study II were quantified using flow cytometry, and GWAS was performed for 92 immune cell phenotypes. Additionally, we performed linear regression analyses of immune cell distributions using polygenic risk scores (PRS) based on prior GWAS for five autoimmune diseases as well as for COVID-19 infection and post-COVID syndrome (âlong COVIDâ). We validated seven previously described immune loci and identified 13 novel loci showing genome-wide significant (α=5.00E-8) association with different immune cell phenotypes. The most significant novel signal was conferred by the SLC52A3 locus, encoding for a riboflavin transporter protein, which was associated with naïve CD57+ CD8+ T cells (p=4.13E-17) and colocalized with SLC52A3 expression. Several novel loci contained immunologically plausible candidate genes, e.g., variants near TBATA and B3GAT1 representing genes associated with T cell phenotypes. The PRS of type 1 diabetes were significantly associated with CD8+ T cells at different differentiation states (pâ€7.02E-4), and PRS of long COVID were associated with early-differentiated CD4+ T cells (pâ€1.54E-4). In conclusion, our extensive immune cell GWAS analyses highlight several novel genetic loci of likely relevance for immune system function. Furthermore, our PRS analyses point to a shared genetic basis between immune cell distributions in healthy adults and T1D (CD8+ T cells) as well as long COVID (CD4+ T cells). +
++PLOS DH (298/300 word limit) Sepsis occurs predominantly in low-middle-income countries. Sub-optimal triage contributes to poor early case recognition and outcomes from sepsis. We evaluated the impact of Smart Triage using improved time to intravenous antimicrobial administration in a multisite interventional study. Smart Triage was implemented (with control sites) in Kenya (February 2021-December 2022) and Uganda (April 2020-April 2022). Children presenting to the outpatient departments with an acute illness were enrolled. A controlled interrupted time series was used to assess the effect on time from arrival at the facility to intravenous antimicrobial administration. Secondary analyses included antimicrobial use, admission rates and mortality (NCT04304235). During the baseline period, the time to antimicrobials decreased significantly in Kenya (132 and 58 minutes) at control and intervention sites, but less in Uganda (3 minutes) at the intervention site. Then, during the implementation period in Kenya, the time to IVA at the intervention site decreased by 98 min (57%, 95% CI 81-114) but increased by 49 min (21%, 95% CI: 23-76) at the control site. In Uganda, the time to IVA initially decreased but was not sustained, and there was no significant difference between intervention and control sites. At the intervention sites, there was a significant reduction in IVA utilization of 47% (Kenya) and 33% (Uganda), a reduction in admission rates of 47% (Kenya) and 33% (Uganda) and a 25% (Kenya) and 75% (Uganda) reduction in mortality rates compared to the baseline period. We showed significant improvements in time to intravenous antibiotics in Kenya but not Uganda, likely due to COVID-19, a short study period and resource constraints. The reduced antimicrobial use and admission and mortality rates are remarkable and welcome benefits but should be interpreted cautiously as these were secondary outcomes. This study underlines the difficulty of implementing technologies and sustaining quality improvement in resource-poor health systems. +
++Purpose: Digital health is an important factor in Indias healthcare system. Inclusive policy measures, a fertile technological landscape, and relevant infrastructural development with unprecedented levels of telemedicine adoption catalysed by the recent COVID-19 pandemic have thrown open new possibilities and opportunities for clinicians, end-users, and other stakeholders. Nevertheless, there are still several challenges to properly integrating and scaling telemedicine use in India. This studys objective was to understand the views of practising physicians in India on the use of telemedicine and the challenges experienced during the accelerated rollout during the first wave of the COVID-19 pandemic. Methods: We acquired data through an anonymous, cross-sectional, internet-based survey of physicians (n=444) across India on the COVID-19 frontline. These responses were subjected to qualitative data analysis (via inductive coding and thematic analyses) and descriptive statistics, as appropriate. Results: Most responses (n=51) were categorised under a code indicating that telemedicine-led healthcare delivery compromised treatment quality. The second largest proportion of responses (n=22) suggested that Accessibility, quality and maturity of software and hardware infrastructure was a considerable challenge. Conclusions: Despite the considerable uptake, perceived benefits, and the foreseen positive role of telemedicine in India, several challenges of telemedicine use (viz., technical, user experience-based integration, and non-user-based integration challenges) have been identified. These must be addressed through suggested relevant opportunities to realise telemedicines potential and help inform the future design of effective telemedicine policy and practice in India. +
++Background: Little is known about public perceptions of antivirals for the treatment of mild-to-moderate COVID-19 in the United States (US). Our objective was to explore adult perceptions toward COVID-19 antivirals with the goal of improving outreach communications about antivirals for COVID-19. Methods: During July 2022, potential respondents 18 years and older were randomly sampled from a national opt-in, non-representative, cross-sectional internet panel, with oversampling of African Americans, Hispanics, and adults 65 years and older. Respondents were asked about sociodemographic factors, and knowledge, attitudes, and perceptions regarding COVID-19 antivirals. Results were weighted to represent the non-institutionalized US adult population. Results: Among 1,155 respondents, 51% were female, 60% were 18-49 years, 21% were 50-64 years, and 19% were 65 years or older. Compared to those aged 18-49 years and 50-64 years, a greater proportion of adults 65 years and older were knowledgeable about COVID-19 antivirals and would take them if they tested positive or their doctor recommended them. Adults 65 years and over and those reporting immunosuppression or disability had the highest rates of willingness to take antivirals. For all groups, the proportion of people willing to take antivirals increased by >20% if recommended by their doctor. Respondents in the 50-64 and 65+ groups who were sure they would take COVID-19 antivirals were more likely to be fully vaccinated and less likely to be living in isolation. Conclusion: Groups that are less likely to have been vaccinated, those living in isolation, and those not sure about whether they would take an antiviral or not may be at risk for not receiving treatment to prevent severe COVID-19 outcomes. However, trust in doctor recommendations may be enough to overcome individual patient concerns about COVID-19 antivirals. Targeted initiatives to educate those at risk for severe COVID-19 outcomes about the effectiveness of antivirals, including those who are unvaccinated given their increased risk of severe disease, may be needed to further lower this population9s risk of severe COVID-19. +
+SGB for COVID-induced Parosmia - Conditions: COVID-19-Induced Parosmia
Interventions: Drug: Stellate Ganglion Block; Drug: Placebo Sham Injection
Sponsors: Washington University School of Medicine
Recruiting
Investigating the Effectiveness of Vimida - Conditions: Long COVID; Post COVID-19 Condition
Interventions: Behavioral: vimida
Sponsors: Gaia AG; Medical School Hamburg; Institut Long-Covid Rostock
Not yet recruiting
Effects of Physiotherapy Via Video Calls on Cardiopulmonary Functions, Physical Function, Cognitive Function, Activity Daily Livings, and Quality of Life in Patients With COVID-19 - Conditions: COVID-19; Long COVID-19; Cardiopulmonary Function; Physical Function
Interventions: Behavioral: Exercise training
Sponsors: Chulabhorn Hospital
Active, not recruiting
Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-COVID-19 Syndrome - Conditions: Post-Acute COVID-19 Syndrome
Interventions: Behavioral: Exercise session; Behavioral: Control session
Sponsors: University of Nove de Julho
Not yet recruiting
Reducing Respiratory Virus Transmission in Bangladeshi Classrooms - Conditions: SARS-CoV2 Infection; Influenza Viral Infections; Respiratory Viral Infection
Interventions: Device: Box Fan; Device: UV Germicidal Irradiation Lamp Unit; Device: Combined: Box Fan and UV Germicidal Irradiation Lamp Units
Sponsors: Stanford University; Centers for Disease Control and Prevention; International Centre for Diarrhoeal Disease Research, Bangladesh
Not yet recruiting
SMILE: Clinical Trial to Evaluate Mindfulness as Intervention for Racial and Ethnic Populations During COVID-19 - Conditions: Anxiety; COVID-19 Pandemic
Interventions: Behavioral: Mindfulness
Sponsors: University of North Carolina, Chapel Hill; National Institute on Minority Health and Health Disparities (NIMHD); RTI International
Not yet recruiting
A Study to Learn About a Combined COVID-19 and Influenza Shot in Healthy Adults - Conditions: Influenza, Human; SARS-CoV-2 Infection; COVID-19
Interventions: Biological: BNT162b2 (Omi XBB.1.5)/RIV; Biological: BNT162b2 (Omi XBB.1.5); Biological: RIV; Other: Normal saline placebo
Sponsors: Pfizer
Recruiting
The Impact of the Covid-19 Pandemic on Orthopedic Trauma Management - Conditions: Trauma; COVID-19 Pandemic
Interventions: Other: epidemyolojical
Sponsors: Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Completed
The Effects of Nutritional Intervention on Health Parameters in Participants With Type 2 Diabetes Mellitus - Conditions: Diabetes Mellitus Type 2; Diabetes Mellitus Type 2 in Obese; Diabetes; Diabetes Mellitus Non-insulin-dependent; Hypertension; Type 2 Diabetes Mellitus
Interventions: Behavioral: Nutritional Intervention
Sponsors: Sao Jose do Rio Preto Medical School; Fundação de Amparo à Pesquisa do Estado de São Paulo
Completed
Open-label, Multi-centre, Non-Inferiority Study of Safety and Immunogenicity of BIMERVAX for the Prevention of COVID-19 in Adolescents From 12 Years to Less Than 18 Years of Age. - Conditions: SARS CoV 2 Infection
Interventions: Biological: BIMERVAX
Sponsors: Hipra Scientific, S.L.U; Veristat, Inc.; VHIR; Asphalion
Recruiting
A Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid - Conditions: Long COVID; Post-Acute COVID-19 Syndrome
Interventions: Drug: Amantadine; Other: Physical, Occupational, Speech Therapy; Other: Provider Counseling; Other: Medications for symptoms management
Sponsors: University of Texas Southwestern Medical Center
Not yet recruiting
Balance Acceptance and Commitment Therapy for Long COVID - Conditions: Post-COVID-19 Syndrome; Long COVID
Interventions: Behavioral: Balance Acceptance and Commitment Therapy
Sponsors: Kingâs College London
Not yet recruiting
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19 - Conditions: COVID-19 Pandemic; Diabetes; Hypertension; Cardiac Disease; Long COVID
Interventions: Behavioral: Incentive Spirometer respiratory training
Sponsors: National Taipei University of Nursing and Health Sciences; Tri-Service General Hospital
Not yet recruiting
Combination of Polygonatum Rhizoma and Scutellaria baicalensis triggers apoptosis through downregulation of PON3 -induced mitochondrial damage and endoplasmic reticulum stress in A549 cells - CONCLUSION: SP inhibits proliferation of lung cancer A549 cells by downregulating PON(3) -induced apoptosis in the mitochondrial and ER pathways.
Omicron BA.4/5 neutralization and cell-mediated immune responses in relation to baseline immune status and breakthrough infection among PLWH: A follow-up cohort study - There is a paucity of data on hybrid immunity (vaccination plus breakthrough infection [BI]), especially cell-mediated responses to Omicron among immunosuppressed patients. We aim to investigate humoral and cellular responses to Omicron BA.4/5 among people living with HIV (PLWH) with/without BIs, the most prevalent variant of concern after the reopening of China. Based on our previous study, we enrolled 77 PLWH with baseline immune status of severe acute respiratory syndrome coronavirus 2âŠ
Low pre-existing endemic human coronavirus (HCoV-NL63)-specific T cell frequencies are associated with impaired SARS-CoV-2-specific T cell responses in people living with HIV - CONCLUSION: Our results indicate that the decrease in SARS-CoV-2 specific T cell responses in PLWH may be attributable to reduced frequencies of pre-existing cross-reactive responses. However, HIV infection minimally affected the quality and magnitude of humoral responses, and this could explain why the risk of severe COVID-19 in PLWH is highly heterogeneous.
Nebulized pH-Responsive Nanospray Combined with Pentoxifylline and Edaravone to Lungs for Efficient Treatments of Acute Respiratory Distress Syndrome - The COVID-19 pandemic has become an unprecedented global medical emergency, resulting in more than 5 million deaths. Acute respiratory distress syndrome (ARDS) caused by COVID-19, characterized by the release of a large number of pro-inflammatory cytokines and the production of excessive toxic ROS, is the most common serious complication leading to death. To develop new strategies for treating ARDS caused by COVID-19, a mouse model of ARDS was established by using lipopolysaccharide (LPS)âŠ.
Influenza vaccination during the 2021/22 season: A data-linkage test-negative case-control study of effectiveness against influenza requiring emergency care in England and serological analysis of primary care patients - We present England 2021/22 end-of-season adjusted vaccine effectiveness (aVE) against laboratory confirmed influenza related emergency care use in children aged 1-17 and in adults aged 50+, and serological findings in vaccinated vs unvaccinated adults by hemagglutination inhibition assay. Influenza vaccination has been routinely offered to all children aged 2-10 years and adults aged 65 years + in England. In 2021/22, the offer was extended to children to age 15 years, and adults aged 50-64âŠ
Evaluation of molecular mechanisms of riboflavin anti-COVID-19 action reveals anti-inflammatory efficacy rather than antiviral activity - CONCLUSIONS: It is concluded that riboflavin reveals anti-inflammatory rather than antiviral activity for SARS-CoV-2 infection.
An enhanced broad-spectrum peptide inhibits Omicron variants in vivo - The continual emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) poses a major challenge to vaccines and antiviral therapeutics due to their extensive evasion of immunity. Aiming to develop potent and broad-spectrum anticoronavirus inhibitors, we generated A1-(GGGGS)7-HR2m (A1L35HR2m) by introducing an angiotensin-converting enzyme 2 (ACE2)-derived peptide A1 to the N terminus of the viral HR2-derived peptide HR2m through a long flexible linker,âŠ
Mesenchymal stromal cells (MSCs) as a therapeutic agent of inflammatory disease and infectious COVID-19 virus: live or dead mesenchymal? - The COVID-19 infection is a worldwide disease that causes numerous immune-inflammatory disorders, tissue damage, and lung dysfunction. COVID-19 vaccines, including those from Pfizer, AstraZeneca, and Sinopharm, are available globally as effective interventions for combating the disease. The severity of COVID-19 can be most effectively reduced by mesenchymal stromal cells (MSCs) because they possess anti-inflammatory activity and can reverse lung dysfunction. MSCs can be harvested from variousâŠ
Genetic justification of COVID-19 patient outcomes using DERGA, a novel data ensemble refinement greedy algorithm - Complement inhibition has shown promise in various disorders, including COVID-19. A prediction tool including complement genetic variants is vital. This study aims to identify crucial complement-related variants and determine an optimal pattern for accurate disease outcome prediction. Genetic data from 204 COVID-19 patients hospitalized between April 2020 and April 2021 at three referral centres were analysed using an artificial intelligence-based algorithm to predict disease outcome (ICU vsâŠ.
Milk Antiviral Proteins and Derived Peptides against Zoonoses - Milk is renowned for its nutritional richness but also serves as a remarkable reservoir of bioactive compounds, particularly milk proteins and their derived peptides. Recent studies have showcased several robust antiviral activities of these proteins, evidencing promising potential within zoonotic viral diseases. While several publications focus on milkâs bioactivities, antiviral peptides remain largely neglected in reviews. This knowledge is critical for identifying novel research directionsâŠ
The Inhibition of Serine Proteases by Serpins Is Augmented by Negatively Charged Heparin: A Concise Review of Some Clinically Relevant Interactions - Serine proteases are members of a large family of hydrolytic enzymes in which a particular serine residue in the active site performs an essential role as a nucleophile, which is required for their proteolytic cleavage function. The array of functions performed by serine proteases is vast and includes, among others, the following: (i) the ability to fight infections; (ii) the activation of blood coagulation or blood clot lysis systems; (iii) the activation of digestive enzymes; and (iv)âŠ
A Narrative Review: The Role of NETs in Acute Respiratory Distress Syndrome/Acute Lung Injury - Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and the alleviation and treatment of ARDS remains a major research focus. There are various causes of ARDS, among which pneumonia and non-pulmonary sepsis are the most common. Trauma and blood transfusion can also cause ARDS. In ARDS, the aggregation and infiltration of neutrophils in the lungs have a great influence on the development of the disease. Neutrophils regulate inflammatory responses through variousâŠ
Unveiling the Antiviral Properties of Panduratin A through SARS-CoV-2 Infection Modeling in Cardiomyocytes - Establishing a drug-screening platform is critical for the discovery of potential antiviral agents against SARS-CoV-2. In this study, we developed a platform based on human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) to investigate SARS-CoV-2 infectivity, with the aim of evaluating potential antiviral agents for anti-SARS-CoV-2 activity and cardiotoxicity. Cultured myocytes of iPSC-CMs and immortalized human cardiomyocyte cell line (AC-16) were primarily characterized for theâŠ
Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres - Trypsin-like serine proteases are involved in many important physiological processes like blood coagulation and remodeling of the extracellular matrix. On the other hand, they are also associated with pathological conditions. The urokinase-pwlasminogen activator (uPA), which is involved in tissue remodeling, can increase the metastatic behavior of various cancer types when overexpressed and dysregulated. Another member of this protease class that received attention during the SARS-CoV 2 pandemicâŠ
Phytochemical Elucidation and Effect of Maesa indica (Roxb.) Sweet on Alleviation of Potassium Dichromate-Induced Pulmonary Damage in Rats - Maesa indica (Roxb.) Sweet is one of the well-known traditionally-used Indian plants. This plant is rich in secondary metabolites like phenolic acids, flavonoids, alkaloids, glycosides, saponins, and carbohydrates. It contains numerous therapeutically active compounds like palmitic acid, chrysophanol, glyceryl palmitate, stigmasterol, ÎČ-sitosterol, dodecane, maesaquinone, quercetin 3-rhaminoside, rutin, chlorogenic acid, catechin, quercetin, nitrendipine, 2,3-dihydroxypropylâŠ
What Do We Owe a Prison Informant? - A man in Georgia says he risked his life for years and was abandoned. But there are very few rules protecting those who provide law enforcement with information. - link
Is the Media Prepared for an Extinction-Level Event? - Ads are scarce, search and social traffic is dying, and readers are burned out. The future will require fundamentally rethinking the pressâs relationship to its audience. - link
The Friendship Challenge - How envy destroyed the perfect connection between two teen-age girls. - link
The Art World Before and After Thelma Golden, by Calvin Tomkins - When Golden was a young curator in the nineties, her shows, centering Black artists, were unprecedented. Today, those artists are the stars of the art market. - link
A Teenâs Fatal Plunge Into the London Underworld - After Zac Brettler mysteriously plummeted into the Thames, his grieving parents were shocked to learn that heâd been posing as an oligarchâs son. Would the police help them solve the puzzle of his death? - link
+States prepare to use Medicaid for rental assistance for the first time. +
++For more than a decade, researchers and advocates have argued that housing is a fundamental part of health care. Beginning this fall, for the first time, federal Medicaid dollars will start going toward paying some peopleâs rent. +
++Itâs a significant policy development. Congressional regulations have long barred Medicaid funds from being used to pay for rent for people staying outside of nursing homes or medical facilities like hospitals. And while some states have used philanthropy or state-based Medicaid funding to pay for housing, those pots of money were extremely limited. Now, with rates of unsheltered homelessness reaching record highs in 2023, and rents growing to their most unaffordable levels ever, some states are preparing to use federal Medicaid dollars in the hopes that health will improve as housing stabilizes. +
++The Biden administration has made this possible through a longstanding Medicaid waiver program that allows states to test out new Medicaid ideas. +
++For nearly a decade, the federal agency that runs Medicare and Medicaid has been warming to the idea that housing could be health care. Since 2015, the Centers for Medicare and Medicaid Services has affirmed that Medicaid funds could go toward services that help people move into new housing, like moving costs or security deposits. In 2018, an influential federal commission told Congress that, while itâs long been known that poor housing conditions can worsen health outcomes, more recent data suggests that providing supportive housing to chronically homeless people also reduces ER visits in ways that case management or other outpatient services does not. +
++The âhousing is health careâ mantra got another major boost during the pandemic, when calls to stay at home to avoid catching and spreading disease grew louder and more urgent. Communities that halted evictions saw lower rates of Covid-19, a stark example of how access to housing is linked to health. +
++And in 2022, the Biden administration encouraged states to consider using Medicaid dollars for âhealth-related social needsâ like housing, nutrition, and transportation â part of a broader White House effort to address social determinants of health. +
++âWe think itâs incredibly exciting,â Dan Tsai, the deputy administrator and director of the Center for Medicaid and CHIP Services, told me. âThis is a firm, clear stance, and we spent about a year of this administration working through how to define and create with guardrails the role of Medicaid in housing and nutrition.â +
++Tsai said their conclusion was based on both common sense and evidence-based practices, that for some groups of people, throwing âthe same old against the wallâ just would not drive better health. +
++Jeff Olivet, the executive director of the US Interagency Council on Homelessness, similarly told me he sees the ability to use Medicaid dollars for purposes like rent as âa real potentially game-changing set of supportsâ to help people exit homelessness and then stay stably housed. +
++Not everyone thinks this possibility is a good move for Medicaid, an already strained federal program with notoriously low reimbursement rates for doctors that disincentive treating patients. Just 3 percent of a stateâs Medicaid spending can go toward âhealth-related social needsâ like housing, but that could still easily amount to billions of dollars annually. Others doubt the claims that paying for housing will drive down overall government spending. +
++Sherry Glied, a dean and professor of public service at New York University, warned recently of âmission creepâ in health systems, arguing that having hospitals and other medical institutions focus on the provision of social services could be a âdangerous distractionâ from their core mission of serving patients, and one that policymakers should discourage. +
++The failure of Congress to dedicate more money to agencies like the Department of Housing and Urban Development is how we got to this point, said senior policy director for National Health Care for the Homeless Council Barbara DiPietro. +
++âMore and more states are desperate to find any help, and thatâs why theyâre turning to Medicaid because theyâre not getting real assistance from HUD,â she told Vox. âAnd Medicaid is an entitlement program while housing is not.â +
++The new pilot program authorizes Medicaid dollars for up to six months of rent and could herald much bigger shifts down the line if state results show improvements in health outcomes or cost-savings. It could also augur much larger shifts across state and federal governments to bring about more comprehensive visions of health care. +
++The federal government has approved a handful of states to use waivers to finance rental assistance for up to six months. The first states to put this into practice are Arizona starting this October, and Oregon this November. The two are planning to target different subpopulations of Medicaid beneficiaries, and both are scrambling to figure out how to make this all possible given shortages of affordable housing. +
++Oregonâs Medicaid program currently provides coverage to roughly 1.5 million Oregonians, and the state estimates 125,000 of those people will soon be eligible to qualify for rental assistance under this new waiver. Oregon is opting to target beneficiaries at risk of becoming homeless, in effect using the funds as a preventive tool to help stave off the devastating economic, physical, and mental harms that come with losing oneâs home. Individuals will literally get a âprescriptionâ for housing. +
++To refer eligible people, the state will look to partner with community-based organizations. Housing nonprofits that get involved in this work will need to train their caseworkers as certified community health workers. +
++âItâs a little scary for them, because they donât want to become medical providers in the same way a doctor doesnât want to become a housing provider,â Dave Baden, the deputy director of Oregonâs Health Authority, told me. âWe canât medicalize the housing world.â +
++Over time, Baden hopes the state will be able to use this kind of funding to pay rent for people living on the streets, but he thinks Oregon needs to increase its housing supply first. +
++âThis Medicaid waiver is not magically going to make housing exist, and I feel like we would have gummed our work to focus on those who were houseless to start with,â he said. âI donât want to create a false benefit where we say, âHey, Amy, hereâs six months of rent, oh, Iâm sorry I donât have any housing for you.ââ +
++Arizona, by contrast, is planning to target people designated as having a serious mental illness, building off a similar but much smaller state program that subsidizes rent for about 3,000 Medicaid beneficiaries each year. +
++That program, which is not time-limited, has been considered an extraordinary success: State data showed financing rent led to a 31 percent reduction in ER visits, a 44 percent reduction in inpatient hospital stays, and savings overall to Arizonaâs Medicaid program of more than $5,500 per member per month. +
++âThatâs one of the big reasons we felt so strongly about pursuing [the 1115 waiver] and being able to federalize some of that work,â said Alex Demyan, an assistant director with Arizonaâs Health Care Cost Containment System. âWeâre in a unique and advantageous position because we have a runway.â +
++With a significant affordable housing shortage, Arizona is looking to authorize a new kind of housing provider to help with supply issues, known as an âenhanced shelter.â These will be new organizations that contract with Medicaid to provide mostly congregate housing, and get reimbursed on a per-diem basis. +
++Demyan sees the opportunity to use Medicaid for rent as potentially transformative. âItâs a huge deal; this kind of cutting-edge work is really what makes working in Medicaid so rewarding in a lot of ways,â Demyan told me. âWe get to play around in the sandbox of health policy and do things differently. I donât think itâs any secret that there are better ways that we can do things.â +
++As Oregon and Arizona â as well as other states that have applied to use federal Medicaid dollars for rent like New York, California, Hawaii, and Washington â prepare for the opportunity, they are hoping to build collaboration between government agencies, private companies, and community nonprofits that historically have rarely worked together. +
++âThere has to be some system-level linkage between the housing and homelessness systems and the medical services; otherwise, we are very concerned about what will happen to people at the end of their six months,â said Marcella Maguire, the director of Health Systems Integration for the Corporation for Supportive Housing. âThis funding will put more people into an already underresourced system. Long-term, I think it will reduce strain, but short-term it will increase strain.â +
++DiPietro, of the National Health Care for the Homeless Council, said she has some worries about how states might use this new Medicaid opportunity to jump people ahead of those waiting in the established line for subsidized housing, or even how receiving Medicaid funding could threaten their eligibility for other homeless services programs. +
++Olivet, of the US Interagency Council on Homelessness, said the eligibility issue is âcertainly on our radar screenâ and that his agency wants to serve as âconnective tissueâ to ensure federal policies are implemented in a strategic way. But state Medicaid departments have a âtremendous roleâ to play in shaping the specifics of each waiver, Olivet added, and coordination between health and housing providers âis where the real work will happen.â +
++Richard Cho, a senior housing and services adviser at HUD, told me thereâs legal precedent for these kinds of eligibility concerns and that his agency is working closely to provide technical assistance to states. +
++When asked if he thinks Medicaid could one day fund rent for longer than six months, Tsai, of CMS, emphasized the importance of getting data first from these pilots. âItâs a huge first step,â he said. âNo one believes Medicaid is here to supplant or replace the role of housing and nutritional agencies, but at the same time, clearly thereâs a better way.â +
++One undoubtedly appealing aspect of the policy proposal is that by paying for housing, Medicaid spending could ultimately go down over time, similar to how it worked with Arizonaâs smaller program. Itâs well-documented that people experiencing homelessness use significantly more health care resources on average than people with stable housing. +
++Proponents point to some encouraging research to back the idea, like a California permanent supportive housing program that reduced the use of expensive medical care and resulted in a roughly 20 percent net savings of total public cost. Another program in New York reduced inpatient hospital days by 40 percent, inpatient psychiatric admissions by 27 percent, and ER visits by 26 percent. +
++But other research evidence is less persuasive. One literature review published in 2022 found âmixed and mostly low-certainty evidenceâ that interventions to drive housing affordability and stability led to improved adult health outcomes. Another study published this month found participants had no difference in ER visits, inpatient use, or chronic disease control, but did report real mental health improvements, particularly from housing providers who showed them compassion. +
++âThe success of health careâbased housing interventions must not be judged solely by short-term chronic disease control and changes in health care use,â the study authors argued. âGiven the complexity of US health care systems, innovations often struggle to demonstrate return on investment ⊠[and] had our evaluation measured only health care use and chronic disease control, we would have overlooked the strong relational connection between patients and their advocates and missed the housing programâs possible effects on the social burden of disease in the current epidemic of social isolation in the US.â +
++Paula Lantz, a professor of health policy at the University of Michigan, told me sheâs very supportive of Medicaid programs getting into housing interventions but has doubts about whether it will ultimately reduce costs, and notes there are moral challenges of really studying that question over time. âIf you have a bunch of people in a control group who you know need services and help and youâre using them for research, the longer [theyâre denied help], the larger the ethical issues there are,â she said. +
++Lantz says she worries that if the waivers donât save Medicaid money, critics might seize on that to attack health care spending more broadly. Demyan, the assistant director with Arizonaâs state Medicaid program, told me he would not be surprised if thereâs âan initial bump in increase in cost of careâ as states transition to this new model. +
++And what if itâs not, ultimately, cost-effective? +
++Tsai, the federal Medicaid official, said heâs confident there are âinefficienciesâ in the system, and that governments can use funding in âwiserâ ways to target certain groups of people. He also stressed the need to think about public savings over time, to remember some that many of the countryâs biggest health disparities didnât happen overnight. +
++Still, Tsai acknowledges, there is currently a lot of âunmet needâ in health care, and saving money isnât the only thing that matters. âThat is why we want to evaluate very objectively,â he said, âand why we want to look at both health outcomes and cost.â +
++
+Congress should have approved Ukraine aid yesterday. +
++As the Senate considered approving $61 billion to Ukraine this weekend, Donald Trump published an all-caps rant making his opposition clear. +
++âFROM THIS POINT FORWARD, ARE YOU LISTENING U.S. SENATE(?), NO MONEY IN THE FORM OF FOREIGN AID SHOULD BE GIVEN TO ANY COUNTRY UNLESS IT IS DONE AS A LOAN,â he wrote on his Truth Social platform on Friday. +
++The Senate rejected Trumpâs order, passing the bill Tuesday morning 70-29. But the bill still needs to clear the Republican-controlled House, where the former presidentâs influence has proven powerful in the past. Indeed, House Speaker Mike Johnson (R-LA) has already stated opposition to the Senate aid bill. +
++Which makes now a good time to remind ourselves that the objections to Ukraine aid are absurd. +
++Supporting Ukraineâs defense is one of the single easiest foreign policy calls of my lifetime, a policy that has both protected Ukrainians from Russian slaughter and advanced Americaâs geopolitical interests in Europe. It has done so at a relatively low cost in dollars and zero cost in American lives. There is nothing to gain by abandoning it, and everything to lose. +
++Letâs start with the most basic point: Russiaâs invasion of Ukraine was an act of evil. Since the warâs beginning, the Russian government and its propaganda outlets have openly announced that their war aim is to seize Ukrainian territory and subjugate its government to the Kremlin. +
++This was evident not just in words, like President Vladimir Putinâs recent interview with Tucker Carlson, but also in deeds. The war began with a failed lightning thrust targeting the Ukrainian capital in Kyiv, during which Russian forces engaged in horrific atrocities: executing entire families and indiscriminately bombing populated areas. +
+ ++There are many problems with the Ukrainian government it is an imperfect democracy whose battlefield performance has worsened as the war degenerated into a kind of stalemate. Its maximalist stated objective of winning all its territory back through force may very well be impossible. +
++But the justice of its basic cause is unimpeachable. Ukraine is fighting a classic war of self-defense, a country protecting its people and its sovereignty from a large neighboring dictatorship that wishes to crush it. +
++And the success of Ukraineâs war hinges crucially on American support. +
++The United States, labeled âthe arsenal of democracyâ during World War II, is playing that role again today. America is providing Ukraine with advanced weapons systems, like HIMARS mobile artillery, and ammunition that neither the Ukrainians nor European allies can get to the field on their own in sufficient numbers. +
++Currently, American funding has been effectively suspended due to the holdup in Congress. We can already see the consequences: Ukrainian fighters, working with a third of the ammunition they need to fight, being forced to retreat. +
++What happens if the aid dries up indefinitely? Voxâs Josh Keating reported on this extensively, and his sources painted a grim picture: +
++++âA failure to supply military aid to Ukraine isnât going to cause an immediate Russian victory, but it is going to change the character of the war,â said Franz-Stefan Gady, a defense analyst with the Center for a New American Security who has made multiple research trips to the front lines in Ukraine. Gady said that while Ukraineâs military has traditionally been an âartillery dominant military force,â without shells for those guns, âthey would likely start pursuing more asymmetric strategies. That is, withdrawing from certain sectors of the front lines into urban settlements, trying to draw Russian forces into urban combat.â +
++This scenario is ⊠a grim prospect for Ukraineâs civilians. Urban combat always has an extremely high civilian death toll and given the heavy-handed tactics employed by the Russian military, the list of Ukrainian cities and towns entirely decimated by war â Mariupol, Bakhmut â would likely grow. +
+
+Even if you see the US government as human rights hypocrites or donât believe protecting Ukrainian lives is Americaâs concern, the outcome of this war directly affects US interests. +
++Currently, the fighting is mostly in Ukraineâs more rural eastern half. If it moves west, into the heart of Ukraineâs largest cities, it moves closer to nearby NATO treaty allies. The odds of a scary spillover incident â of a miscalculation that could trigger a wider war between Russia and the American-led alliance â would rise accordingly. +
++At present, the best way to limit the risk of war between nuclear-armed powers is to help Ukraine keep Russia physically further away from NATO borders. Continuing aid, by contrast, is unlikely to trigger a direct escalation between Russia and the United States â as the past two years of fighting have shown. +
++Again, it is unlikely that Ukraine will simply defeat Russia and win back all of its territories. The most likely scenario for the warâs end is â like most wars â negotiation. +
++But as in any negotiation, leverage matters. Political scientists often describe war as itself a process of bargaining, one in which itâs rational for states to continue fighting until the balance of power between the two sides is clear. To bring about a settlement in which Russiaâs aggression is punished rather than rewarded, Ukraine needs to be strong on the battlefield. +
++And if Russia is rewarded, it has an incentive to engage in more provocations on NATOâs frontier. A world where Ukraine is forced to the table by American abandonment is a vastly more dangerous one. +
++Sixty-one billion dollars sure sounds like a lot of money. But the amount it purchases â sovereignty for an embattled democracy, civilian safety from Russian massacres, and decreasing the odds of a terrifying wider war â is easily worth the price. For Congress to do anything but rush it through would be an appalling betrayal not just of Ukraine, but of America. +
++This story appeared originally in Today, Explained, Voxâs flagship daily newsletter. Sign up here for future editions. +
+Is the situation really so dire for Democrats? Tuesdayâs special election will give us a clue. +
++Even the race to replace George Santos in Congress is packed with drama. +
++The historic expulsion of Santos in December has prompted a rare special election in a swing congressional district that could prove a bellwether for November. A Democratic win in New Yorkâs Third Congressional District, which Joe Biden won by 8 in 2020, would further shrink the already tenuous Republican majority and make it that much easier for Democrats to win back the House. A Republican hold, though, would be a huge boost for the GOP in the Long Island district located on the edge of New York City. After all, if they can survive George Santosâs scandals in the suburbs, perhaps they can survive Donald Trumpâs too. +
++Democrats are running perhaps their strongest possible candidate in the district: former Rep. Tom Suozzi. Suozzi represented the seat for three terms before giving it up in 2022 for a long-shot primary challenge to incumbent Gov. Kathy Hochul. Suozzi is a longtime local politician who is well-liked and has cultivated a moderate image. In contrast, the Republican candidate, Mazi Pilip, is a relative newcomer to politics, albeit one with a sterling biography. A first-term member of the county legislature and a mother of seven, Pilip is an Ethiopian Jew who served in the Israel Defense Forces before immigrating to the United States with her husband. She has run a cautious, sheltered campaign, dodging reporters and holding relatively few public events. +
++The limited public polling available shows that the race will be very close. A recent Newsday/Siena College poll shows Suozzi with a narrow 48 percent to 44 percent lead, and one from Emerson College gives the Democrat an almost identical 50 percent to 47 percent margin. Both polls show Biden being deeply unpopular in the district with an approval rating under 40 percent, and the Siena poll shows Donald Trump winning a head-to-head matchup against Biden by a 47 percent to 42 percent margin in the district. +
++First of all, itâs close because no one particularly cares about George Santos anymore. The disgraced former Congress member hasnât been a major issue in the election, and local Republicans have done a good job of distancing themselves from him. Most called for Santos to be ousted from Congress over a year ago, and now Santos is simply viewed by voters as an aberration. +
++But there are also dynamics on the ground in the district that make it different from other suburban areas where Democrats have surged in the Trump era. Instead, it was a place where Republicans had made significant gains in local elections in recent years. Steve Israel, who represented a similar district in Congress for eight terms before retiring in 2016, told Vox that âit had strongly over-performed for Republicans and underperformed for Democrats, even while Democrats have been winning handily in suburbs across the rest of the country.â +
++In particular, Israel pointed to anxiety about crime and migrants in a district that borders New York City. âWhen progressives talked about defunding the police and cashless bail, that pushes a lot of moderate suburban voters to Republicans,â said the former Democratic representative. âA lot of suburban voters are either cops or know cops.â Further, he pointed out that âa lot of suburban voters [in the district] commute to New York City. So youâve had this perfect storm of headlines on crime. And then add to that more recent headlines about migrants being bused into Manhattan. And that has triggered anxieties in a population that is generally moderate, that is generally progressive on social issues.â +
++These trends were clear in 2022 when Republicans overwhelmingly carried the district. Lee Zeldin, the GOP nominee for governor, won it by double digits as Republicans picked up a number of House seats in New York while having a disappointing night elsewhere. +
++The other key factor keeping things close is the strength of the Nassau County Republican Party. Itâs one of the last political machines in the country and has a strong get-out-the-vote operation that has been credited with helping Republicans win an array of local races in recent years and creating a strong bench in the district. Thereâs the belief among Republicans that, if the race is close, it will carry Pilip to victory, despite the fact that Suozzi and his allies have outspent her on TV and radio ads. +
++At the most basic level, a Democratic win on Tuesday reduces the Republican majority on Capitol Hill to just three votes. With House Speaker Mike Johnson struggling to keep his conference united, this will make his task that much harder as Congress faces yet another government funding deadline in March â let alone as he deals with contentious issues like aid to Ukraine and immigration reform. A Republican win would give him just a little extra breathing room and provide a morale boost. +
++Further, Democrats see their path to taking back the House as winning the 18 GOP congressional districts that Joe Biden won in 2020. This is one of them, and if they canât pick up this one, it bodes ill for their prospects in the other 17 districts â particularly the six other districts in New York and New Jersey. +
++At a broader level, it becomes a referendum on how much the migrant crisis will be an issue in 2024. As unprecedented numbers of undocumented immigrants enter the United States, straining social services in cities across the country, the issue has become increasingly front of mind for voters. Republicans have harped on it throughout the campaign, forcing Suozzi to go on the defensive about it. With the special election being the only one held in a competitive seat before Novemberâs presidential election, the result will be a key data point moving forward on the topic. +
++It will also be a measuring stick for how much abortion will continue to be a live political issue now that more than a year has passed since the Supreme Court overturned Roe v. Wade. Suozzi has run as a stalwart pro-abortion-rights candidate, while Pilip has broadly labeled herself as âpro-lifeâ while dodging more detailed questions about how she would vote on Capitol Hill. +
++And as Democrats respectively stay focused on abortion and Republicans on immigration, the result on Tuesday will be a clear indicator which of the two issues voters are more focused on ahead of November. +
Young sailors Banny and Akshay await their big break - HYDERABAD
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Premier League | Chelsea snatch last-gasp win at struggling Palace - The 3-1 win was Chelseaâs 13th straight league win over Crystal Palace â a club record.
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Reality tech firm unveils digital twin of Mohammed Quli Qutb Shahâs tomb -
Former I-T officer inducted into Kerala CMâs personal staff as reward for his clean chit in SNC-Lavalin case, alleges Shaun George - Shaun George alleges that R. Mohan gave clean chit to Pinarayi Vijayan in his capacity as Additional Director of Income Tax, Director General of Income Tax, Kochi, in a report dated July 24, 2008
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Watch: Huge fire engulfs new Swedish water park - Video shows huge flames and thick smoke rising from large water slides in Gothenburg.
Europe âneeds a decade to build up arms stocksâ - The head of Rheinmetall, Germanyâs biggest defence firm, says Europeâs ammunition stocks are currently empty.
Polish state TV host decries past anti-LGBT output - Wojciech Szelag apologised to LGBT people for the TVP Info channelâs âhateful wordsâ targeted at them.
A new generation of storm chasers takes on Mother Nature in Twisters trailer - âYou donât face your fears, you ride âem.â - link
Ongoing campaign compromises senior execsâ Azure accounts, locks them using MFA - The wide range of employee roles targeted indicates attackerâs multifaceted approach. - link
F-Zero courses from a dead Nintendo satellite service restored using VHS and AI - Thereâs still a $5,000 prize for the original Japanese Satellaview broadcasts. - link
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Roman soldier says, âWe lost a man and now number only 99â. His centurion replies, âI seeâ. The soldier responds⊠-
++No, XCIX +
+ submitted by /u/NYY15TM
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Mary is invited to her boyfriend Johnnyâs home for dinner and to meet his parents -
++Sheâs very nervous about meeting them, and is on her best manners so as to ensure she gives her best impression. +
++The parents are warm and seem pleased to make her acquaintance after all theyâve heard from Johnny. The family dog Fido is also very friendly and soon takes a liking to her. +
++They sit to sumptuous dinner which the parents have prepared and begin eating and making conversation. Fido wants to stay close to his new best friend and seats himself uunder Maryâs chair. +
++Soon into the meal, Mary begins to regret the extra large burger she had for lunch. The gas is building uncomfortably inside her and she realises she has no choice but to let it out. Not wanting to make a bad impression she carefully squeezes the fart out as quietly as she can. Only the slightest noise can be heard and nobody seems to notice. But nobody could ignore the smell. The mother looks over in Maryâs direction, spots Fido and sternly exclaims âFido!â. Mary is relieved to be rid of her fart and relieved that Fido has taken the blame. +
++The evening continues amicably but soon the pressure begins to build again. Mary lets another, bigger fart free, a little more boldly this time. Everyone could hear and nobody would be able to mistake the direction the fart came from. Fortunately, to Maryâs satisfaction, the mother again looks toward Mary then at Fido and once more exclaims âFido!â. The poor dog looks up guiltily. Mary feels a little bad for the dog but is glad to have a way to relieve herself without embarassing herself. +
++Mary is relaxed now, getting along very well with the parents and confident that she is making a good impression on her boyfriendâs parents. The pressure of another large fart again builds in her gut but now she knows the dog will take the blame she doesnât bother holding back. She letâs free a roaring, explosive and eye-watering fart that makes everyone stop their dinner. The mother puts her utensils down, rubs her eyes and angrily shouts at the dog âFido! This is the last time! Get out from under there before she shits on you!â +
+ submitted by /u/robreim
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A Union Brothel -
++A grumpy old man walks into a brothel and asks the madam âIs this a union brothel?â âNo, sir,â she replies âIâve owned and operated this bordello for 50 years without a union!â âWell, Iâm a union man, so I only visit union brothels!â the man replies as he slams the door on his way out. +
++Three more cathouses, the same thing. Until he visits the very last bang shack in town; where the madam says âWhy yes, weâre the only union pleasure house this side of the Mississippi!â +
++âThatâs great!â he shouted excitedly âI want an hour with your prettiest, most voluptuous girl!â +
++âIâm sure you do.â she replied âBut Agnes has seniority!â +
+ submitted by /u/daschande
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What do you call a man with no arms and no legs fighting with his cat? -
++Claude +
+ submitted by /u/kickypie
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John asks his high school crush Mary to the senior prom -
++The day arrives, and he picks her up in his dadâs car, sporting a fresh new suit, and heâs just buzzing with excitement to be going out with the most beautiful girl in the world. +
++Once they arrive Mary insists they take their picture together - itâs a long line of other couples but eventually they get to the front and get their picture +
++Afterward they make their way to the auditorium and Mary turns to John and says, âooohh they have cookies! Will you get me one?â John quickly obliges, only to find that thereâs another long line at the concession table. He eventually secures a chocolate chip cookie and brings it over to Mary. +
++âThis is amazing but listen, I didnât have diner yet, will you get me a slice of pizza?â John agrees, eager to make his date happy and once again waits in the long line for pizza. +
++He returns with the food and watches her eat, very eager to get to dance with her. She looks up at him and bats her eyelashes âJohn, this has all made me rather thirsty, will you bring me a glass of punch?â +
++John obliges again, eager to impress his date. He makes his way over to the drink table and finds that thereâs no punch line. +
+ submitted by /u/rebekoning
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