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+ + + ++The COVID-19 global crisis is facilitated by high virus transmission rates and high percentages of asymptomatic and presymptomatic infected individuals. Containing the pandemic hinged on combinations of social distancing and face mask use. Here we examine the efficacy of these measures, using an agent-based modeling approach that evaluates face masks and social distancing in realistic confined spaces scenarios. We find face masks are more effective than social distancing. Importantly, combining face masks with even moderate social distancing provides optimal protection. The finding that widespread usage of face masks limits COVID-19 outbreaks can inform policies to reopening of social functions. +
++A year since the declaration of the global coronavirus disease 2019 (COVID-19) pandemic there have been over 110 million cases and 2.5 million deaths. Using methods to track community spread of other viruses such as poliovirus, environmental virologists and those in the wastewater based epidemiology (WBE) field quickly adapted their existing methods to detect SARS-CoV-2 RNA in wastewater. Unlike COVID-19 case and mortality data, there was not a global dashboard to track wastewater monitoring of SARS-CoV-2 RNA worldwide. This study describes the development of the COVIDPoops19 dashboard to disseminate information regarding sites, universities, research institutions and private laboratories in countries that are involved in WBE for SARS-CoV-2. Methods to assemble the dashboard combined standard literature review, direct submissions, and daily, social media keyword searches. Over 200 universities, 1,000 sites, and 50 countries with 59 dashboards monitor wastewater for SARS-CoV-2 RNA. However, monitoring is inequitably distributed in high-income countries and data are not widely shared publicly or accessible to researchers to inform public health actions, meta-analysis, better coordinate, and determine equitable distribution of monitoring sites. For WBE to be used to its full potential during COVID-19 and beyond, show us the data. +
+Dose-Ranging Study to Assess the Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19 - Condition: COVID-19
Interventions: Drug: Melatonin; Drug: Placebo
Sponsors: State University of New York at Buffalo; National Center for Advancing Translational Science (NCATS)
Not yet recruiting
A Study to Evaluate the Efficacy and Safety of Brilacidin in Hospitalized Participants With COVID-19 - Condition: COVID-19
Interventions: Drug: Brilacidin; Drug: Placebo; Drug: Standard of Care (SoC)
Sponsor: Innovation Pharmaceuticals, Inc.
Recruiting
Evaluation of ADG20 for the Treatment of Mild or Moderate COVID-19 - Condition: COVID-19
Interventions: Drug: ADG20; Drug: Normal saline
Sponsor: Adagio Therapeutics, Inc.
Not yet recruiting
A Study to Evaluate the Safety and Efficacy of OT-101+Artemisinin in Hospitalized COVID-19 Subjects - Condition: COVID-19
Interventions: Drug: OT-101; Drug: Artemisinin; Drug: Placebo
Sponsor: Oncotelic Inc.
Not yet recruiting
Study of mRNA Vaccine Formulation Against COVID-19 in Healthy Adults 18 Years of Age and Older - Condition: COVID-19
Interventions: Biological: SARS-CoV-2 mRNA vaccine formulation 1; Biological: SARS-CoV-2 mRNA vaccine formulation 2; Biological: SARS-CoV-2 mRNA vaccine formulation 3; Biological: Placebo (0.9% normal saline)
Sponsor: Sanofi Pasteur, a Sanofi Company
Recruiting
Trial to Determine the Efficacy/Safety of Plitidepsin vs Control in Patients With Moderate COVID-19 Infection - Condition: COVID-19 Infection
Interventions: Drug: Plitidepsin; Drug: Dexamethasone; Drug: Remdesivir
Sponsor: PharmaMar
Not yet recruiting
Safety and Immunogenicity Study of a SARS-CoV-2 (COVID-19) Variant Vaccine (mRNA-1273.351) in Naïve and Previously Vaccinated Adults - Conditions: COVID-19; COVID-19 Immunisation
Interventions: Biological: mRNA-1273; Biological: mRNA-1273.351
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); ModernaTX, Inc.
Not yet recruiting
Safety and Tolerability of Emricasan in Symptomatic Outpatients Diagnosed With Mild-COVID-19 - Condition: Covid19
Interventions: Drug: Emricasan; Other: Placebo
Sponsor: Histogen
Recruiting
Efficacy of Reinforcing Standard Therapy in COVID-19 Patients With Repeated Transfusion of Convalescent Plasma - Condition: Covid19
Interventions: Other: Convalescent Plasma with antibody against SARS-CoV-2.; Other: Standard treatment for COVID-19
Sponsors: Hospital Son Llatzer; Fundació d’investigació Sanitària de les Illes Balears
Recruiting
Diagnostic Performance of the ID Now™ COVID-19 Screening Test Versus Simplexa™ COVID-19 Direct Assay - Condition: Covid19
Intervention: Diagnostic Test: ID Now™ COVID-19 Screening Test
Sponsor: Groupe Hospitalier Paris Saint Joseph
Active, not recruiting
A Phase 2 Study of Human Monoclonal Antibodies, BRII-196 and BRII-198 - Condition: COVID-19
Interventions: Drug: BRII-196 and BRII-198; Drug: Placebo
Sponsors: Brii Biosciences Limited; TSB Therapeutics (Beijing) CO.LTD
Not yet recruiting
Off-the-shelf NK Cells (KDS-1000) as Immunotherapy for COVID-19 - Condition: Covid19
Interventions: Biological: KDS-1000; Other: Placebo
Sponsor: Kiadis Pharma
Not yet recruiting
A Study to Assess if a Medicine Called Bamlanivimab is Safe and Effective in Reducing Hospitalization Due to COVID-19 - Condition: Covid19
Interventions: Biological: Bamlanivimab; Other: Standard of Care
Sponsors: Fraser Health; Fraser Health Authrority Department of Evaluation and Research Services; Surrey Memorial Hospital Clinical Research Unit; Centre for Health Evaluation and Outcome Sciences; Surrey Hospitals Foundation; BC Support Unit; University of British Columbia; Ministry of Health, British Columbia
Not yet recruiting
Effects of Telerehabilitation After Discharge in COVID-19 Survivors - Condition: Covid19
Intervention: Other: Telerehabilitation
Sponsor: Hacettepe University
Recruiting
Corticosteroids for COVID-19 - Condition: Covid19
Interventions: Drug: Prednisone; Device: Point of Care testing device for C-reactive protein
Sponsor: University of Alberta
Not yet recruiting
Etoricoxib may inhibit cytokine storm to treat COVID-19 - The worldwide spread of COVID-19 has caused an unprecedented disaster. The emergence of COVID-19-mediated cytokine storm is one of the most important contributors to the development of acute and severe illness in patients. At present, there is an urgent need for drugs that can inhibit cytokine storm to treat COVID-19. In the absence of specific drugs and vaccines, it is important to screen existing drugs as potential treatments. This article introduces a potential repositioning of the existing…
(1)H, (13)C and (15)N Backbone chemical shift assignments of the n-terminal and central intrinsically disordered domains of SARS-CoV-2 nucleoprotein - The nucleoprotein (N) from SARS-CoV-2 is an essential cofactor of the viral replication transcription complex and as such represents an important target for viral inhibition. It has also been shown to colocalize to the transcriptase-replicase complex, where many copies of N decorate the viral genome, thereby protecting it from the host immune system. N has also been shown to phase separate upon interaction with viral RNA. N is a 419 amino acid multidomain protein, comprising two folded,…
Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccines - Phylogenetic and pathogenesis studies of the severe acute respiratory syndrome-related coronaviruses (SARS-CoVs) strains have highlighted some specific mutations that could confer the RNA genome fitness advantages and immunological resistance for their rapid spread in the human population. The analyses of 30 kb RNA SARS-CoVs genome sequences, protein structures, and functions have provided us a perspective of how host-virus protein-protein complexes act to mediate virus infection. The open…
CCR5Delta32 deletion as a protective factor in Czech first-wave COVID-19 subjects - Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease (COVID-19), has spread widely around the globe. Significant inter-individual differences have been observed during the course of the infection, which suggests that genetic susceptibility may be a contributing factor. CC chemokine receptor 5 (CCR5), which acts as a co-receptor for the entry of HIV-1 into cells, is promising candidate whose can have an influence on SARS-CoV-2…
Immunoinformatics and Molecular Docking Studies Predicted Potential Multiepitope-Based Peptide Vaccine and Novel Compounds against Novel SARS-CoV-2 through Virtual Screening - CONCLUSION: Our investigations predicted epitopes and the reported molecules that may have the potential to inhibit the SARS-CoV-2 virus. These findings can be a step towards the development of a peptide-based vaccine or natural compound drug target against SARS-CoV-2.
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 - COVID-19 pandemic is the third zoonotic coronavirus (CoV) outbreak of the century after severe acute respiratory syndrome (SARS) in 2003¹ and Middle East respiratory syndrome (MERS) since 2012². Treatment options for CoVs are largely lacking. Here we show that clofazimine, an anti-leprosy drug with a favourable safety profile³, possesses pan-coronaviral inhibitory activity, and can antagonize SARS-CoV-2 and MERS-CoV replication in multiple in vitro systems. The FDA-approved molecule was found to…
A brief review on potential application of mesenchymal stem cell and secretome in combating mortality and morbidity in COVID-19 patients - Coronavirus disease 2019 (COVID-19) caused by novel Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2), is typically associated with severe respiratory distress and has claimed more than 525,000 lives already. The most fearful aspect is the unavailability of any concrete guidelines and treatment or protective strategies for reducing mortality or morbidity caused by this virus. Repurposing of drugs, antivirals, convalescent plasma and neutralizing antibodies are being considered for…
Human coronaviruses and therapeutic drug discovery - CONCLUSIONS: During the spread of COVID-19 outbreak, great efforts have been made in therapeutic drug discovery against the virus, although the pharmacological effects and adverse reactions of some drugs under study are still unclear. However, well-designed high-quality studies are needed to further study the effectiveness and safety of these potential drugs so as to provide valid recommendations for better control of the COVID-19 pandemic.
COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial - OBJECTIVES: The main goal of the COVIDENZA trial is to evaluate if inhibition of testosterone signalling by enzalutamide can improve the outcome of patients hospitalised for COVID-19. The hypothesis is based on the observation that the majority of patients in need of intensive care are male, and the connection between androgen receptor signalling and expression of TMPRSS2, an enzyme important for SARS-CoV-2 host cell internalization.
A review: Mechanism of action of antiviral drugs - Antiviral drugs are a class of medicines particularly used for the treatment of viral infections. Drugs that combat viral infections are called antiviral drugs. Viruses are among the major pathogenic agents that cause number of serious diseases in humans, animals and plants. Viruses cause many diseases in humans, from self resolving diseases to acute fatal diseases. Developing strategies for the antiviral drugs are focused on two different approaches: Targeting the viruses themselves or the host…
Computational approach to decipher cellular interactors and drug targets during co-infection of SARS-CoV-2, Dengue, and Chikungunya virus - The world is reeling under severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, and it will be frightening if compounded by other co-existing infections. The co-occurrence of the Dengue virus (DENV) and Chikungunya virus (CHIKV) has been into existence, but recently the co-infection of DENV and SARS-CoV-2 has been reported. Thus, the possibility of DENV, CHIKV, and SARS-CoV-2 co-infection could be predicted in the future with enhanced vulnerability. It is essential to elucidate…
Seroconversion stages COVID19 into distinct pathophysiological states - COVID19 is a heterogeneous medical condition involving diverse underlying pathophysiological processes including hyperinflammation, endothelial damage, thrombotic microangiopathy, and end-organ damage. Limited knowledge about the molecular mechanisms driving these processes and lack of staging biomarkers hamper the ability to stratify patients for targeted therapeutics. We report here the results of a cross-sectional multi-omics analysis of hospitalized COVID19 patients revealing that…
Repurposing CFDA-approved drug carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2 - COVID-19 pandemic caused by SARS-CoV-2 infection severely threatens global health and economic development. No effective antiviral drug is currently available to treat COVID-19 and any other human coronavirus infections. We report herein that a CFDA-approved macrolide antibiotic, carrimycin, potently inhibited the cytopathic effects (CPE) and reduced the levels of viral protein and RNA in multiple cell types infected by human coronavirus 229E, OC43, and SARS-CoV-2. Time-of-addition and…
The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue - To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications “off-label” against SARS-CoV-2. Fluoxetine inhibited SARS-CoV-2 at a concentration of 0.8 µg/ml significantly in these screenings, and the EC50 was determined with 387 ng/ml. Furthermore, Fluoxetine reduced viral infectivity in precision-cut human lung slices showing its…
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins - The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic, leading to millions of infections and hundreds of thousands of human deaths. The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human innate immune responses, although the viral proteins responsible for this immune evasion are not clear. In this study, we identified SARS-CoV-2 structural proteins, accessory proteins, and the main viral protease as potent inhibitors of host innate…
Peptides and their use in diagnosis of SARS-CoV-2 infection - - link
A PROCESS FOR SUCCESSFUL MANAGEMENT OF COVID 19 POSITIVE PATIENTS - - link
Sars-CoV-2 vaccine antigens - - link
SARS-COV-2 BINDING PROTEINS - - link
+
Lüftungssystem für einen mit öffnbaren Fenstern (16) ausgestatteten Gebäuderaum, gekennzeichnet dadurch, dass es ein Gehäuse (18) und einen Ventilator (20) aufweist, wobei durch das Gehäuse eine vom Ventilator erzeugte Luftströmung strömen kann, wobei das Gehäuse dafür eine Einströmöffnung (24) für Luft und eine Ausströmöffnung (22) für Luft enthält, wobei eine der beiden Öffnungen der Form eines Öffnungsspalts (26) zwischen einem Fensterflügel (12) und einem Blendrahmen (14) des Fensters (16) angepasst ist.
X射线图像识别方法、装置、计算机设备及存储介质 - 本申请涉及一种X射线图像识别方法、装置、计算机设备和存储介质。通过获取X射线图像,将X射线图像作为训练样本;构建多注意力交互网络,多注意力交互网络包括卷积批处理标准化网络、特征提取网络和输出网络;其中特征提取网络包括多注意力交互特征提取模块和批标准化模块,特征提取网络通过学习通道之间的相关性,多通道之间的信息交互来达到增强模型的识别能力。利用训练样本对多注意力交互网络进行训练,得到X射线图像识别模型;获取待测X射线图像;将待测X射线图像输入到X射线图像识别模型中,得到X射线图像的类别。本方法减少了网络的参数量和计算量,提高了模型的泛化能力。 - link
利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法 - 本发明提供一种利用HEK293细胞制备新型冠状病毒核衣壳蛋白的方法,包括:1)构建新冠病毒核衣壳蛋白(N蛋白)重组表达载体;2)用重组表达载体转染HEK293细胞;3)体外培养细胞,从培养上清中分离纯化N蛋白。利用HEK293表达系统可在短时间内获得大量新冠病毒N蛋白,通过一步亲和层析法可获得纯度高达98%以上的N蛋白。与大肠杆菌相比,采用HEK293表达系统制备的N蛋白在与抗体的结合活性及新冠抗体胶体金检测方面均表现出极大优势,且HEK293表达系统制备的N蛋白其蛋白空间构象接近于病毒N基因在宿主体内的蛋白表达构象,具有更高的免疫诊断和抗体制备的准确性,将其用于制作诊断试剂和疫苗前景广阔。 - link
Compositions and methods for detecting SARS-CoV-2 spike protein - - link
偶联新型冠状病毒S2蛋白的磁珠及其制备方法与应用 - 本发明提供偶联新型冠状病毒S2蛋白的磁珠及其制备方法与应用。所述偶联新型冠状病毒S2蛋白的磁珠是将表面修饰有链霉亲和素的磁珠与生物素标记的新型冠状病毒S2蛋白结合制得的。本发明还提供偶联后磁珠的冻干过程,以及偶联后磁珠的酵母展示scFv文库的筛选。该磁珠具有结合能力强,特异性好,稳定性高,便于操作的特点,既可用于新冠病毒S2抗体的富集,也可用于表达S2抗体的酵母细胞的淘选。利用本发明磁珠进行S2蛋白抗体的富集和表达S2蛋白抗体的细胞筛选,可将低浓度的特异性抗体捕获后进行浓缩,提高了灵敏度。在酵母展示scFv文库细胞筛选上,比流式细胞分选方法所需周期短,可快速筛出目标克隆酵母细胞,提高筛选效率。 - link
靶向SARS-CoV-2的抗体及其制备方法和应用 - 本发明提供了靶向SARS‑CoV‑2的抗体及其制备方法和应用,该抗体包含VH和VL,所述VH包含以下CDR:氨基酸序列如SEQ ID NO:1、2、3所示的VH CDR1、VH CDR2、VH CDR3;所述VL包含以下的CDR:氨基酸序列如SEQ ID NO:4、5、6所示的VL CDR1、VL CDR2、VL CDR3。该抗体能够高亲和且特异地结合SARS‑CoV‑2的S蛋白的RBD,抑制RBD蛋白与受体ACE2蛋白的结合,高效地抑制SARS‑CoV‑2感染细胞,同时对潜在的免疫逃逸突变的假病毒具有很好的中和活性,从而可有效应用于SARS‑CoV‑2病毒及相关疾病的诊断、预防和治疗中。 - link
Why COVID-19 Vaccines Aren’t Yet Available to Everyone - President Biden has promised that all adults will be eligible to receive a vaccine by May. But manufacturing and distributing enough doses will depend on a lot of things going right. - link
Flowers for Sarah Everard - In the aftermath of a horrific kidnapping and murder, the U.K. reckons with the omnipresence of misogyny. - link
A Kansas Bookshop’s Fight with Amazon Is About More Than the Price of Books - The owner of the Raven bookstore, in Lawrence, wants to tell you about all the ways that the e-commerce giant is hurting American downtowns. - link
Larry Summers Versus the Stimulus - Could the passage of a $1.9 trillion coronavirus-relief package mark the end of the neoliberal era? - link
H.R. 1 Is About Climate, Too - The For the People Act says nothing about carbon emissions or solar panels, but it’s still the most important piece of climate legislation today. - link
+I grew up in a “nonworking” family. Biden’s child benefit would’ve been a godsend. +
++Shortly after I turned 8, my father died, leaving my mother a widow. Financially, they had prepared for the worst: life insurance, money in the bank, and a plan for my mother, who had sustained a serious back injury in her previous job at a nursing home, to begin earning a salary in a few years. +
++But then my brother was diagnosed with a disability. Different therapists labeled it different things: ADHD, autism, dyslexia, grief. None of these labels came close to communicating the direness of the situation. He was incapable of doing even the smallest amount of schoolwork without an adult standing by to keep him on task. Later, he developed extreme sensory sensitivities that led to frequent meltdowns at school. After sending him to various schools incapable of handling the problem, my mother resorted to homeschooling. After years of trying to balance this with finding a job, she ran out of my father’s pension as well as her savings. Ultimately, she suffered a stroke that left her unable to speak or live independently and was declared incompetent, unable to be responsible even for herself. +
++Throughout this story, my family was ineligible for any kind of government assistance — not food stamps, not the child tax credit (which requires income), not Temporary Assistance for Needy Families. But recently, the Biden administration announced a benefit as part of the Covid-19 relief package that we would have been eligible for: an expanded child tax credit that allows parents to claim up to $3,600 a year per child under 6 and $3,000 a year for children ages 6 to 17. It’s a huge step toward alleviating many of the financial pressures associated with having children in the modern world. For the moment, the larger credit is available for only one year, but it could easily provide a blueprint for things to come. +
++Immediately after this announcement, there followed a debate in some corners of the internet: Should this child benefit include all parents, or only those who have jobs and are “behaving responsibly?” +
++I understand the impulse to ensure the government isn’t discouraging people from working. I grew up attending a conservative religious school in southern Illinois, where the teachers liked to throw around the phrase, “He who does not work shall not eat.” It’s an ethos I still admire as an adult. +
++But here’s the thing: Child care is work. Even in perfectly average families, it’s work that often complicates holding down a paid job. We’ve developed various ways of dealing with this reality, including public schools, paid day cares, maternity leave, and an acceptance that some people are going to be stay-at-home parents, at least while their children are too small to attend school. But many parents still fall through the cracks of these systems. +
++Unlike most government aid programs, this new proposal isn’t aimed at people specifically because they’re poor. Instead, it’s aimed at those who do a certain kind of work: parenting. Nonworking households — or, more accurately, households where no one has a paid job — still experience all of the financial burdens associated with having children. In 2019, there were just under 3 million of these households, comprising 8.7 percent of families with children younger than 18. That number is just 2.5 percent for households with two parents, and it includes a lot of people for whom unemployment is a temporary state. +
++Significantly, only 64.2 percent of two-parent households with children under 18 include two working parents. When there are two people to share the burdens associated with child care, more than a third of households choose to leave someone home with the children. My mother was one of these parents before her husband died. She was in good company — unpaid child care is arguably the most common full-time job in America. +
++For single parents like my widowed mother, things are harder. Without the flexibility of another person to watch the children, these parents are sometimes unable to hold down two full-time jobs at once. If the parent or one of the children is dealt an unexpected blow — a serious injury, a death in the extended family — two full-time jobs can become outright impossible to manage. Throw in something like a pandemic and an economic crash, and it becomes even harder. +
++Without support, nonworking families eventually end up the way mine did. My clearest memories are of the first three years of high school, when money was tightest. By that point, my mother had accepted she could return to work only if we could find a way to manage my brother’s disability. Like most parents, she kept the specific numbers of our budget a secret from her children, but I understood the general principle: Every dollar we spent left us with less time to find a solution. Absolutely nothing was really in our budget, so we came to reexamine what “absolutely need” meant many times over the course of running out of money. TV was declared nonessential, and we stopped paying for it. We determined we could get by for years without new clothes. When we had budgeting exercises in class, I would dismissively tell my teachers it was easy — all you had to do was never buy anything. +
++By sophomore year, I was spending my Friday nights working the concession stand at my school’s football and basketball games. For five hours of work, I earned $7, which went into a school account that could only be used to purchase dance tickets. More importantly, I was given a free dinner for the night, and I was sometimes allowed to take the extra hot dogs home at the end of my shift. My mother would very seriously thank me, telling me the extra food would really help us. +
++I got really good at appealing to other people’s pity. I was always on the lookout for free food, free clothing, free transportation. I got other students to include me in their carpool to school by waking up at six in the morning. I begged fruit and vegetables off other people’s plates at lunch. It worked out for me, more or less. I was eventually given a privately funded scholarship for high school students who had overcome great adversity (it was the only thing that made it possible for me to attend college). The truth, though, is that living on other people’s pity is pretty terrible, even when all of the people involved are great. You never know when they’re going to decide you don’t need their help anymore — or worse, that you’re no longer worthy of it. +
++The expanded child tax credit is not based on pity. It doesn’t limit itself to those who need it. It defines parents by the work they do — parenting — rather than by their poverty or bad luck. If we specifically excluded “nonworking” parents from a benefit that is offered to all others, we’d be denying it to the parents who need it most. But more than that, we would be denying it to the parents who deserve it most: those for whom parenting has required the greatest sacrifices and are working to overcome the greatest obstacles. +
++My mother never stopped trying to stand up under the weight of her obligations. In fact, just before her stroke, there was a brief ray of hope. She had finally gotten my brother into a charter school, which allowed her to dive back into the process of retraining to become an art therapist. By that point, she was exhausted. But even after years of being beaten down and humiliated for her poverty, her fighting spirit still had not been entirely crushed. After several more months of practical training, she successfully earned her license. If she hadn’t landed in the hospital a month later, she would have eventually rejoined the workforce. +
++The new child tax credit wouldn’t have prevented my father’s death. It wouldn’t have kept my brother from becoming disabled. It wouldn’t have prevented my mother’s stroke. While the best doctors and therapists can be helpful if you have enough resources, even they can do only so much. +
++I do think, however, that it would have given her the resources to do a better job at the work she had devoted herself to: raising her children. It would have been enough to keep the fridge stocked. It would have been enough to try a different psychiatrist for my brother. It would have been enough that she didn’t have to spend time crying over the electric bill. Perhaps most importantly, I think it would have helped preserve that fighting spirit. I think it would have helped her recognize that the work she was doing was valued, that she was not less of a parent just because her children required more care than others. +
++June Kreml is an ex-evangelical Catholic writer and child care worker who lives in Oakland, California. +
+Brands want to help consumers imagine a post-pandemic world, but they’re cautious about celebrating prematurely. +
++In early March, a viral campaign from the menswear company Suitsupply provided a brief, harrowing glimpse into our post-pandemic future — and the advertisements that might usher us into it. The featured models were entangled in a web of tanned limbs, touching aggressively and tongue-kissing sloppily. Everyone was scantily clad except for the campaign’s lead man, dressed in a tailored suit. The “new normal,” the Suitsupply advertisement teased, would be sexy, sweaty, and sensual. +
++The raunchy images set off a frenzy of reactions online, but the campaign’s success at generating discourse led to suggestions that horniness and hedonism might be embraced as brand marketing tactics with the new new normal in sight. Some experts think few companies will be as brash, and instead integrate slow and steady changes in tone when it comes to ads and social media campaigns. Don’t be fooled, though. The summer of 2021 could possibly be the horniest of our lifetimes: We’ve missed the anonymous comfort of dark, crowded spaces and the adrenaline-fueled messiness of a night out among strangers. +
++Sean Cassidy, president of the public relations firm DKC, told me that the CEO of a major media company believed that “by September, some places will feel like a cross between the Roaring ’20s and the Summer of Love.” Most of us have lived the past year operating under “an abundance of caution”: Just last March, brands (even those we barely have relationships with) were flooding our inboxes with updates about the novel coronavirus, detailing all sorts of safety measures and contingency plans. They emphasized ideas of “community” and “health,” and explained how they were “monitoring” the developing “situation.” Vox’s Rebecca Jennings pointed out how even the fashion brand Reformation, known for sending ridiculously random email subject lines, briefly tamped down its over-eager tone. +
++As the pandemic became less novel, so did brand messaging. Reformation and the thousands of brands we have parasocial relationships with have returned to their usual antics. This week, I received an email from nuuly, Urban Outfitters’ subscription clothing service, with an all-caps subject line: IN CASE OF FAMILY EVENTS. In case of which family events? My mom isn’t even vaccinated yet! (In an earnings call on March 2, Urban Outfitters said it has seen increased interest in going-out clothes.) +
++The emails and messages we receive might only become more zealous or carefree. “The tone of paid content will be increasingly optimistic with higher than normal doses of temptation sprinkled in,” Cassidy said. The return to true normalcy is expected to be a slow burn, which leaves more room for error from a public relations standpoint. The timeline for the US to achieve herd immunity is still in flux, despite President Joe Biden’s call to open vaccinations to all adults by May 1. There is no global end date to the pandemic. Plus, economic recovery isn’t a guarantee: Economists don’t expect unemployment rates to bounce back to pre-pandemic levels within 2021. Consumer spending is still being “propped up artificially” through the federal government’s stimulus program, according to Ted Rossman, a senior industry analyst at Bankrate. +
++The fractured nature of America’s recovery makes it incredibly difficult for brands to shape their messaging. Many might hesitate to emulate Suitsupply’s unabashed horniness, especially since consumers have become more consciously critical, even derisive, toward brandspeak. In lockdown, we spent more time online, and encountered an oversaturation of ad content. And the various corporate solidarity statements and initiatives in the wake of the summer’s Black Lives Matter protests weren’t immune to public scrutiny. +
++“I don’t think we’re going to see a sudden switch from brands. It’ll likely be more subtle and slow when it comes to brands adapting to some sort of opening in the future,” said Jenny Gyllander, founder of Thingtesting, a review website for emerging direct-to-consumer brands. “It’s interesting to see the tone of voice changing. I think we’re seeing more optimism, humor, and bold visuals.” +
++The “sensuality” of the Suitsupply ad, she added, doesn’t hold universal appeal for everyone’s experiences in the wake of the pandemic. Some emerging brands have fully leaned into the domestic cozy aspect of quarantine, while emphasizing self-care and the importance of home. While Suitsupply’s campaign went viral, it’s uncertain whether the uptick in online attention translated into significant sales, or communicated loyalty or care to customers. +
++Brand activity during the last year has been overwhelming, and it’s time for companies to shift their outreach, Gyllander said: “In the coming months, I think many will lean towards a hybrid sort of messaging because our lives are not going to quickly return to normal. Most of us will still work from home. Restaurants will still do takeout.” +
++Gyllander predicted certain themes like connection and hope might be more appealing for a wider segment of consumers. We can safely assume, however, that a subset of quirky brands will capitalize on the tempting thrills of vaccination season. Quarantine has led us — social media managers of brands included — to embrace being “horny on main.” +
++Consumers have generally been responsive to ads that showcase intimacy and socialization in a post-pandemic future, Business Insider reported. There has been “a giant spike in the utilization of people in intimate photos” in advertising, according to Pattern89, an artificial intelligence ad company. Still, advertisers are struggling to determine which messages are appropriate to lean into, given the many inequities heightened by the pandemic. There’s the added emotional toll and trauma of the coronavirus that can’t be waved away, and it’ll take time for some to enjoy a renewed world where we are free to touch and talk with strangers. +
++“It has been a horrible year,” Cassidy said. “A lot of consumers want permission to feel a little good, but optimism doesn’t mean recklessness. I tell our clients to avoid any event, stunt, or message that remotely implies any condoning of unsafe, insensitive, or unethical activity under the guise of optimism.” +
++It’s possible the advertising industry could experience a boom, as it did in the aftermath of World War II. Brands then were selling the American future, one that encouraged people to “overcome repressed desires and encourage enjoyment in consumption on a mass scale,” according to Joseph Malherek, a historian of capitalism and American consumer culture. +
++It’s tempting to draw historical parallels with the post-war period: Most Americans had sacrificed years of comfort and luxury to contribute to the war effort, and it was the job of advertisers to lure consumers to spend with the vision of a prosperous, automated future. Today, though, we can collectively roll our eyes at the performative sexuality and hedonism encouraged by the wildest ads, since we no longer need them to tell us how to live. We already are familiar with excess. It’s only a matter of time before we can indulge again. +
++A new study shows that industrial fishing has serious, unreported carbon emissions. +
++Seafood has generally been considered part of a low-carbon diet, but new research points to a surprising link between fishing and carbon emissions. Bottom trawling — a widespread fishing practice — emits as much carbon dioxide as airplanes do annually, a study published Wednesday in the journal Nature found. +
++Bottom trawling, which entails dragging a weighted net along the ocean floor to catch low-lying seafood such as shrimp, crab, and flounder, is notorious for wreaking havoc on ecosystems. In addition to the species the trawler targets, turtles and other marine life can get caught in the large nets and can die as a result. +
++On top of that, we’re learning that trawlers also release significant carbon dioxide emissions into the ocean by disrupting carbon-rich sediments when they rake the seafloor. +
++Countries have an opportunity to tackle this newfound source of emissions and protect marine species later this year. World leaders are expected to convene in Kunming, China, for the most significant United Nations biodiversity negotiations in a decade. Facing an escalating sixth mass extinction, a leading bloc of nations is calling for the conservation of 30 percent of land and 30 percent of oceans by 2030. +
++This new study may help inform those negotiations. It shows that protecting biodiversity doesn’t have to mean cutting off seafood supplies — and that fishing sector emissions can be slashed at the same time. +
++“Usually we’ll talk about these things separately,” said Rashid Sumaila, a professor of fisheries economics at the University of British Columbia who was not involved in the study. “Adding the three together is new. They are all actually interconnected, and they are all pointing to the same thing: We’re putting too much pressure on our natural systems.” +
++Let’s look at how the researchers say nations can tackle these three problems at once. +
++Warning signs about the ocean’s deteriorating health have emerged in recent years; for instance, one-third of fish stocks were being fished at unsustainable levels as of 2017, according to the UN Food and Agriculture Organization. But this is the first time researchers have calculated the staggering global emissions from bottom trawling. +
++To figure out this sector’s carbon footprint, the team behind the Nature study underwent a painstaking process of reviewing mining records and other data to compile a map of the carbon stored in seabeds globally. Then they overlaid that map with data from the nonprofit Global Fishing Watch showing where trawlers have been active. Lastly, they modeled the emissions released when dormant, carbon-rich sediment is kicked up by that trawling activity and consumed by microbes, converting it into carbon dioxide. +
++The answer: 1.47 gigatons (as of 2016). That’s more than Japan’s annual emissions, and comparable to what the airline industry is responsible for. +
+ ++What’s more, an area isn’t depleted of carbon after being trawled once. Emissions are still released for up to 400 years at a rate of 40 percent of the initial year’s emissions as new layers of sediments are disrupted, the study found. +
++“That, to me, was the extremely shocking part. In the foreseeable future, there’s no end to this if we continue to trawl,” said Trisha Atwood, an associate professor of watershed sciences at Utah State University and a co-author of the study. +
++Notably, these emissions aren’t totally equivalent to the carbon dioxide released by cars and factories on land. According to Atwood, while a large proportion of the carbon dioxide released by trawling will likely end up in the atmosphere in the long run, some stays in the ocean. (Their research on the precise amount is ongoing.) +
++The emissions that remain in the water also have serious consequences. One of the biggest issues has to do with the ocean’s role as a carbon sink. The ocean already absorbs more than a third of annual carbon dioxide emissions. However, scientists expect that human-induced greenhouse gas emissions will overwhelm the uptake process, causing it to slow down this century. +
++If the ocean doesn’t absorb as much carbon, that means more will end up in the atmosphere, stoking global warming. By adding more emissions to the ocean, trawling emissions exacerbate this problem. +
+ ++“If we’re adding the entire aviation fleet’s worth of greenhouse gas emissions into the ocean every year just from trawling, that’s going to reduce the ability of the ocean to take up more atmospheric CO2,” Atwood said. At the same time, the emissions also increase ocean acidification, which has devastating effects on the world’s coral reefs, among other things. +
++To tackle the problem, countries need to start documenting these ocean emissions along with land-based emissions in their inventories, Atwood said. “I think there needs to be a program developed to start accounting for emissions in the ocean in the same way, because once we lose the ocean as a sink, we’re really in trouble,” she added. This kind of inventory could also help hold the trawling industry accountable, just as the electricity and auto industries are targeted for emissions reductions. +
++If an international agreement is struck at this year’s UN biodiversity summit to preserve 30 percent of the ocean, nations will have an opportunity to design protected areas with these newfound emissions in mind. +
++To stop 90 percent of the seabed emissions from trawling, just 3.6 percent of the ocean would need to be protected, according to the study. But that’s still a challenge: Only 2.7 percent of the ocean is “fully” or “highly” protected today, meaning that no fishing, mining, or habitat destruction is allowed within those areas. +
++China is currently in a league of its own when it comes to trawling emissions and therefore would benefit most from additional protections from a carbon perspective. Russia, Italy, the UK, and Denmark follow. +
+ ++However, rather than focusing on just one outcome, the researchers emphasize that countries can optimize for all three goals — fishing stocks, biodiversity, and carbon reduction — if they design their marine protected areas carefully. Critically, the authors found that increasing marine protected areas (MPAs) can boost fish supplies instead of diminishing them. +
++If countries were to value biodiversity and fish stocks equally, the ideal optimization would be to protect 45 percent of the ocean, which would lead to 71 percent of the maximum biodiversity benefits, 92 percent of the possible food benefits, and 29 percent of the carbon benefits. +
++Here, the authors treat carbon benefits as secondary, since marine protected areas are currently designed with a primary focus on biodiversity. +
++But Atwood hopes this study will help bring more visibility to trawling emissions and their significance. The carbon benefits from preventing trawling are being considered for inclusion in carbon markets, she said. That could actually make this problem part of the biodiversity solution. +
++“If there is a way for them to leverage the carbon benefit from [creating MPAs], it is a potential pathway for paying for marine protected areas,” Atwood said. +
++Until then, more than two dozen startups riding the wave of an emerging fish welfare movement — and the growing awareness of overfishing and fish farming problems — would love it if you tried some plant-based fish. +
Joan Laporta takes office as FC Barcelona president - Messi was at Laporta’s inauguration at the Camp Nou Stadium on Wednesday and embraced the new president during the ceremony
Bayern beats Lazio for Champions League quarterfinal spot - Lewandowski netted in the first half to end Lazio’s slim hopes of a comeback as Bayern beat the Italian club 2-1 at home Wednesday to seal a 6-2 aggregate win
All England: Saina retires due to injury, four Indians enter 2nd round of men’s singles - Prannoy and Praneeth, however, have a tough task at hand.
Chelsea march into Champions League quarters with win over Atletico - Chelsea beat Atletico Madrid 2-0 on Wednesday to reach the Champions League quarter-finals for the first time since 2014 as Hakim Ziyech and Emerson
National Hard Court Tennis | Digvijay stuns Abhinav - Renne cruises past Sudipta
Monkey menace: Govt. plans sterilisation drive in Malnad - Infrastructure and manpower ready for operation, says Minister
Kerala society needs more enlightenment - ‘Only LDF has the determination and sense of purpose to fight communalism’
Parliament Proceedings | Less than 10 lakh children with Severe Acute Malnutrition identified, Government tells Rajya Sabha - In a written reply in the Upper House, Women and Child Development Minister Smriti Irani said identification and management of severe acute malnutrition is an ongoing process.
Rolling out of new National Education Policy won’t be delayed by pandemic, Rajya Sabha told - The NEP, approved by the Union Cabinet last year, replaces the 34-year-old National Policy on Education framed in 1986.
Puducherry Assembly polls | BJP manifesto to be released on March 24 - The document would be launched most likely by Union Finance Minister Nirmala Sitharaman
Dutch election: PM Mark Rutte claims victory and fourth term - Voters hand Mark Rutte a new coalition mandate while a liberal, centre-left party also does well.
Covid: EU plans rollout of travel certificate before summer - It will permit travel by those vaccinated, or who have tested negative or recently recovered.
Paris Commune: The revolt dividing France 150 years on - Passions flare over how to remember the city’s brief, much-romanticised experiment in power to the people.
Covid-19: EU warns UK over vaccine exports - The EU threatens to block vaccine exports to the UK unless it “gets its fair share”.
Russia recalls envoy after Biden remarks about Putin - President Joe Biden says Russian leader Vladimir Putin will “pay” for alleged election meddling.
Distraction, not partisanship, drives sharing of misinformation - But getting people to pay attention to news quality doesn’t seem to help much. - link
~4,300 publicly reachable servers are posing a new DDoS hazard to the Internet - DDoS-for-hire services adopt new technique that amplifies attacks 37 fold. - link
FreeBSD kernel-mode WireGuard moves forward out-of-tree - Development has been moved to Donenfeld’s own zx2c4.com for the time being. - link
Amid panic over AstraZeneca vaccine, WHO urges countries to keep using it - COVID vaccines don’t prevent blood clots, which are common in the general population. - link
Intel hires Justin Long to mock Macs in throwback to 2000s “I’m a Mac” ads - “No one really games on a Mac.” - link
+Call that luck of the IRS. +
+ submitted by /u/Jacob4L
[link] [comments]
+A guy asked a girl in a university library:
“Do you mind if I sit beside you?”
+
+The girl replied with a loud voice:
“I DON’T WANT TO SPEND THE NIGHT WITH YOU!”
+
+All the students in the library started staring at the guy; he was truly embarrassed. After a couple of minutes, the girl walked quietly to the guy’s table and said:
“I study psychology, and I know what a man is thinking. I guess you felt embarrassed, right?”
+
+The guy then responded with a loud voice:
“$500 FOR ONE NIGHT!? THAT’S TOO MUCH!”
+
+All the people in the library looked at the girl in shock. The guy
whispered in her ear:
“I study law, and I know how to screw people”
+
submitted by /u/Spandan-N
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+That has left scientists scratching their heads. +
+ submitted by /u/porichoygupto
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+The other says “careful, that’s hot.” +
+ submitted by /u/invertedparadX
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+He said, “Look at my hair. It used to be so magnificent, but it’s completely gone now. My hair can’t be saved. But look outside at the forest. It’s such a lovely forest with so many trees, but sooner or later they’ll all be cut down and this forest will look as bald as my hair.” +
++“What I want you to do…” the man continued. “Is, every time a tree is cut down or dies, plant a new one in my memory. Tell your descendants to do the same. It shall be our family’s duty to keep this forest strong.” +
++So they did. +
++Each time the forest lost a tree, the children replanted one, and so did their children, and their children after them. +
++And for centuries, the forest remained as lush and pretty as it once was, all because of one man and his re-seeding heirline. +
+ submitted by /u/honolulu_oahu_mod
[link] [comments]