++The worldwide COVID-19 pandemic has had devastating effects on health, healthcare infrastructure, social structure, and economics. One of the limiting factors in containing the spread of this virus has been the lack of widespread availability of fast, inexpensive, and reliable methods for testing of individuals. Frequent screening for infected and often asymptomatic people is a cornerstone of pandemic management plans. Here, we introduce two pH sensitive ″LAMPshade″ dyes as novel readouts in an isothermal RT-LAMP amplification assay for SARS-CoV-2 RNA. The resulting JaneliaLAMP (jLAMP) assay is robust, simple, inexpensive, has low technical requirements and we describe its use and performance in direct testing of contrived and clinical samples without RNA extraction. +
++This study applied causal criteria in directed acyclic graphs for handling covariates in associations for prognosis of severe COVID-19 (Corona virus disease 19) cases. To identify nonspecific blood tests and risk factors as predictors of hospitalization due to COVID-19, one has to exclude noisy predictors by comparing the concordance statistics (AUC) for positive and negative cases of SARS-CoV-2 (acute respiratory syndrome coronavirus 2). Predictors with significant AUC at negative stratum should be either controlled for their confounders or eliminated (when confounders are unavailable). Models were classified according to the difference of AUC between strata. The framework was applied to an open database with 5644 patients from Hospital Israelita Albert Einstein in Brazil with SARS-CoV-2 RT-PCR (Reverse Transcription - Polymerase Chain Reaction) exam. C-reactive Protein (CRP) was a noisy predictor: hospitalization could have happen due to causes other than COVID-19 even when SARS-CoV-2 RT-PCR is positive and CRP is reactive, as most cases are asymptomatic to mild. Candidates of characteristic response from moderate to severe inflammation of COVID-19 were: combinations of eosinophils, monocytes and neutrophils, with age as risk factor; and creatinine, as risk factor, sharpens the odds ratio of the model with monocytes, neutrophils, and age. +
++Introduction Several antigen tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed worldwide, but their clinical utility has not been well established. In this study, we evaluated the analytical and clinical performance of QuickNavi™-COVID19 Ag, a newly developed antigen test in Japan. Methods This prospective observational study was conducted at a PCR center between October 7 and December 5, 2020. The included patients were referred from a local public health center and 89 primary care facilities. We simultaneously obtained two nasopharyngeal samples with flocked swabs; one was used for the antigen test and the other for real-time reverse transcription PCR (RT-PCR). Using the results of real-time RT-PCR as a reference, the performance of the antigen test was evaluated. Results A total of 1186 patients were included in this study, and the real-time RT-PCR detected SARS-CoV-2 in 105 (8.9%). Of these 105 patients, 33 (31.4%) were asymptomatic. The antigen test provided a 98.8% (95% confident interval [CI]: 98.0%-99.4%) concordance rate with real-time RT-PCR, along with a sensitivity of 86.7% (95% CI: 78.6%-92.5%) and a specificity of 100% (95% CI: 99.7%-100%). False-negatives were observed in 14 patients, 8 of whom were asymptomatic and had a low viral load (cycle threshold (Ct) >30). In symptomatic patients, the sensitivity was 91.7% (95% CI: 82.7%-96.9%). Conclusion QuickNavi™-COVID19 Ag showed high specificity and sufficient sensitivity for the detection of SARS-CoV-2. This test is a promising potential diagnostic modality especially in symptomatic patients. +
++We tested the hypothesis that not wearing face masks, old age, and obesity can largely explain COVID-19 death rates across countries. In the regression analysis, they contributed to 61.5%, 40.5%, and 43.8%, respectively, and a model including all these variables contributed to 70.2% of the variation in the cumulative number of COVID-19 deaths per million on May 13, 2020, in 22 countries. We also proposed the hypothesis that these variables may be confounders of other suspected factors with large differences between Western and non-Western countries, such as the BCG vaccination policy. These results contribute to the elucidation of differences in COVID-19 death rates between countries and support a suspected causal effect of face masks. +
++Objective: We aimed to identify the country-level determinants of the severity of the first wave of the COVID-19 pandemic. Design: An ecological study design of publicly available data was employed. Countries reporting >25 COVID-related deaths until 08/06/2020 were included. The outcome was log mean mortality rate from COVID-19, an estimate of the country-level daily increase in reported deaths during the ascending phase of the epidemic curve. Potential determinants assessed were most recently published demographic parameters (population and population density, percentage population living in urban areas, median age, average body mass index, smoking prevalence), Economic parameters (Gross Domestic Product per capita); environmental parameters: pollution levels, mean temperature (January-May)), co- morbidities (prevalence of diabetes, hypertension and cancer), health system parameters (WHO Health Index and hospital beds per 10,000 population); international arrivals, the stringency index, as a measure of country-level response to COVID-19, BCG vaccination coverage, UV radiation exposure and testing capacity. Multivariable linear regression was used to analyse the data. Primary Outcome: Country-level mean mortality rate: the mean slope of the COVID-19 mortality curve during its ascending phase. Participants: Thirty-seven countries were included: Algeria, Argentina, Austria, Belgium, Brazil, Canada, Chile, Colombia, the Dominican Republic, Ecuador, Egypt, Finland, France, Germany, Hungary, India, Indonesia, Ireland, Italy, Japan, Mexico, the Netherlands, Peru, the Philippines, Poland, Portugal, Romania, the Russian Federation, Saudi Arabia, South Africa, Spain, Sweden, Switzerland, Turkey, Ukraine, the United Kingdom and the United States. Results: Of all country-level predictors included in the multivariable model, total number of international arrivals (beta 0.033 (95% Confidence Interval 0.012,0.054)) and BCG vaccination coverage (-0.018 (-0.034,-0.002)), were significantly associated with the mean death rate. Conclusions: International travel was directly associated with the mortality slope and thus potentially the spread of COVID-19. Very early restrictions on international travel should be considered to control COVID outbreak and prevent related deaths. +
++The ongoing COVID-19 pandemic has shifted attention to the airborne transmission of exhaled droplet nuclei within indoor environments. The spread of aerosols through singing and musical instruments in music performances has necessitated precautionary methods such as masks and portable purifiers. This study investigates the effects of placing portable air purifiers at different locations inside a classroom, as well as the effects of different aerosol injection rates (e.g., with and without masks, different musical instruments and different injection modes). Aerosol deposition, airborne concentration and removal are analyzed in this study. It was found that using purifiers could help in achieving ventilation rates close to the prescribed values by the World Health Organization (WHO), while also achieving aerosol removal times within the Center of Disease Control and Prevention (CDC) recommended guidelines. This could help in deciding break periods between classroom sessions, which was around 25 minutes through this study. Moreover, proper placement of purifiers could offer significant advantages in reducing airborne aerosol numbers (offering orders of magnitude higher aerosol removal when compared to nearly zero removal when having no purifiers), and improper placement of the purifiers could worsen the situation. The study suggests the purifier to be placed close to the injector to yield a benefit, and away from the people to be protected. The injection rate was found to have an almost linear correlation with the average airborne aerosol suspension rate and deposition rate, which could be used to predict the trends for scenarios with other injection rates. +
+Dendritic Cell Vaccine to Prevent COVID-19 - Condition: COVID-19
Intervention: Biological: AV-COVID-19
Sponsors: Indonesia-MoH; Aivita Biomedical, Inc.; PT AIVITA Biomedika Indonesia; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia; RSUP Dr. Kariadi Semarang, indonesia; Faculty of Medicine University of Diponegoro, Indonesia
Recruiting
Effect of Dalcetrapib in Patients With Confirmed Mild to Moderate COVID-19 - Condition: Covid19
Interventions: Drug: Dalcetrapib; Other: Placebo
Sponsors: DalCor Pharmaceuticals; The Montreal Health Innovations Coordinating Center (MHICC); Covance
Not yet recruiting
suPAR-Guided Anakinra Treatment for Management of Severe Respiratory Failure by COVID-19 - Condition: Covid19
Interventions: Drug: Anakinra; Drug: Placebo
Sponsor: Hellenic Institute for the Study of Sepsis
Recruiting
Evaluating the Impact of EnteraGam In People With COVID-19 - Condition: Covid19
Interventions: Dietary Supplement: Bovine Plasma-Derived Immunoglobulin Concentrate; Other: Standard of care
Sponsors: Entera Health, Inc; Lemus Buhils, SL; Clinical Research Unit, IMIM (Hospital del Mar Medical Research Institute)
Not yet recruiting
Efficacy and Safety of Remdesivir and Tociluzumab for the Management of Severe COVID-19: A Randomized Controlled Trial - Conditions: Covid19; Covid-19 ARDS
Interventions: Drug: Remdesivir; Drug: Tocilizumab
Sponsors: M Abdur Rahim Medical College and Hospital; First affiliated Hospital of Xi'an Jiaoting University
Recruiting
Inhaled Ivermectin and COVID-19 - Condition: COVID-19
Intervention: Drug: Ivermectin Powder
Sponsor: Mansoura University
Not yet recruiting
Effect of Tenofovir/Emtricitabine in Patients Recently Infected With SARS-COV2 (Covid-19) Discharged Home - Condition: Covid19
Intervention: Drug: tenofovir disoproxil and emtricitabine
Sponsor: University Hospital, Caen
Recruiting
Safety and Immunogenicity of Two Different Strengths of the Inactivated COVID 19 Vaccine ERUCOV-VAC - Condition: COVID-19 Vaccine
Interventions: Biological: ERUCOV-VAC; Other: Placebo Vaccine
Sponsors: Health Institutes of Turkey; TC Erciyes University
Recruiting
AZD1222 Vaccine in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19 - Condition: COVID-19
Interventions: Biological: AZD1222; Biological: rAd26-S
Sponsors: AstraZeneca; R-Pharm
Not yet recruiting
Anti-COVID19 AKS-452 - ACT Study - Condition: Covid19
Intervention: Biological: AKS-452
Sponsors: University Medical Center Groningen; Akston Biosciences Corporation
Not yet recruiting
Study in Adults to Determine the Safety and Immunogenicity of AZD1222, a Non-replicating ChAdOx1 Vector Vaccine, Given in Combination With rAd26-S, Recombinant Adenovirus Type 26 Component of Gam-COVID-Vac Vaccine, for the Prevention of COVID-19. - Condition: COVID-19
Interventions: Biological: AZD1222; Biological: rAd26-S
Sponsors: R-Pharm; AstraZeneca
Not yet recruiting
Surgical Face Mask Effects in Patients With COVID-19 - Condition: Covid19
Intervention: Other: Sit-To-Stand test
Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Not yet recruiting
Dendritic Cell Vaccine, AV-COVID-19, to Prevent COVID-19 Infection - Condition: COVID-19
Interventions: Biological: AV-COVID-19; Other: GM-CSF
Sponsors: Aivita Biomedical, Inc.; PT AIVITA Biomedika Indonesia; Indonesia Ministry of Health; National Institute of Health Research and Development, Ministry of Health Republic of Indonesia
Recruiting
Efficacy and Safety of hzVSF-v13 in Patients With COVID-19 Pneumonia - Condition: COVID-19
Interventions: Drug: hzVSF-v13; Drug: Placebo (Normal saline solution)
Sponsor: ImmuneMed, Inc.
Recruiting
A Clinical Study to Assess the Efficacy and Safety of Amizon® Max in the Treatment of Moderate Covid-19 - Condition: Covid-19 Disease
Interventions: Drug: Enisamium Iodide; Drug: Placebo
Sponsor: Joint Stock Company "Farmak"
Recruiting
ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study - Angiotensin-converting enzyme 2 (ACE2) and serine protease TMPRSS2 have been implicated in cell entry for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). The expression of ACE2 and TMPRSS2 in the lung epithelium might have implications for the risk of SARS-CoV-2 infection and severity of COVID-19. We use human genetic variants that proxy angiotensin-converting enzyme (ACE) inhibitor drug effects and cardiovascular risk...
Hydroxychloroquine as a Chemoprophylactic Agent for COVID-19: A Clinico-Pharmacological Review - Hydroxychloroquine has gained much attention as one of the candidate drugs that can be repurposed as a prophylactic agent against SARS-CoV-2, the agent responsible for the COVID-19 pandemic. Due to high transmissibility and presence of asymptomatic carriers and presymptomatic transmission, there is need for a chemoprophylactic agent to protect the high-risk population. In this review, we dissect the currently available evidence on hydroxychloroquine prophylaxis from a clinical and...
Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2 - Outbreak of coronavirus disease 2019 occurred in Wuhan and has rapidly spread to almost all parts of world. GB-1, the herbal formula from Tian Shang Sheng Mu of Chiayi Puzi Peitian Temple, is used for the prophylaxis of SARS-CoV-2 in Taiwan. In this study, we investigated that the effect of GB-1 and the index compounds of GB-1 on the ACE2 and TMPRSS2 expression through in vitro and in vivo study. In our result, GB-1 can inhibit ACE2 and TMPRSS2 protein expression in HepG2 cells, 293T cells, and...
Excited-state electronic properties, structural studies, noncovalent interactions, and inhibition of the novel severe acute respiratory syndrome coronavirus 2 proteins in Ripretinib by first-principle simulations - Ripretinib is a recently developed drug for the treatment of adults with advanced gastrointestinal stromal tumors. This paper reports an attempt to study this molecule by electronic modeling and molecular mechanics to determine its composition and other specific chemical features via the density-functional theory (DFT), thereby affording sufficient information on the electronic properties and descriptors that can enable the estimation of its molecular bioactivity. We explored most of the...
Synthesis of novel indolo[3,2-c]isoquinoline derivatives bearing pyrimidine, piperazine rings and their biological evaluation and docking studies against COVID-19 virus main protease - A series of hybrid indolo[3,2-c]isoquinoline (δ-carboline) analogs incorporating two pyrimidine and piperizine ring frameworks were synthesized. Intending biological activities and SAR we propose replacements of fluorine, methyl and methoxy of synthetic compounds for noteworthy antimicrobial, antioxidant, anticancer and anti-tuberculosis activities. Among these compounds 3a, 4a and 5e were progressively strong against E. coli and K. pneumonia. Whereas, compounds 4a, 5a and 6a with addition of...
Tetracycline plus macrolide: A potential therapeutic regimen for COVID-19? - The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that struck in late 2019 and early 2020 is a serious threat to human health. Since there are no approved drugs that satisfactorily treat this condition, all efforts at drug design and/or clinical trials are warranted and reasonable. Drug repurposing is a well-known strategy that seeks to deploy existing licensed drugs for newer indications and that provides the quickest possible transition from the bench...
Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label nonrandomized clinical trial - Curcumin is proposed as a potential treatment option for coronavirus disease-19 (COVID-19) by inhibiting the virus entrance, encapsulation and replication, and modulating various cellular signaling pathways. In this open-label nonrandomized clinical trial, efficacy of nano-curcumin oral formulation has been evaluated in hospitalized patients with mild-moderate COVID-19. Forty-one patients who fulfilled the inclusion criteria were allocated to nano-curcumin (n = 21) group (Sinacurcumin soft gel,...
CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapy - Designing anticoronavirus disease 2019 (anti-COVID-19) agents is the primary concern of medicinal chemists/drug designers nowadays. Repurposing of known active compounds against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new effective and time-saving trend in anti-COVID-19 drug discovery. Thorough inhibition of the coronaviral-2 proteins (i.e., multitarget inhibition) is a possible powerful favorable strategy for developing effectively potent drugs for COVID-19. In...
Remdesivir: From Ebola to COVID-19 - Human coronaviruses (HCoV) were discovered in the 1960s and were originally thought to cause only mild upper respiratory tract diseases in immunocompetent hosts. This view changed since the beginning of this century, with the 2002 SARS (severe acute respiratory syndrome) epidemic and the 2012 MERS (Middle East respiratory syndrome) outbreak, two zoonotic infections that resulted in mortality rates of approximately 10% and 35%, respectively. Despite the importance of these pathogens, no approved...
Propedia: a database for protein-peptide identification based on a hybrid clustering algorithm - CONCLUSIONS: Propedia is a database and tool to support structure-based rational design of peptides for special purposes. Protein-peptide interactions can be useful to predict, classifying and scoring complexes or for designing new molecules as well. Propedia is up-to-date as a ready-to-use webserver with a friendly and resourceful interface and is available at: https://bioinfo.dcc.ufmg.br/propedia.
Evaluation of a commercially-available surrogate virus neutralization test for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) - There remains an urgent need for assays to quantify humoral protective immunity to SARS-CoV-2 to understand the immune responses of COVID-19 patients, evaluate efficacy of vaccine candidates in clinical trials, and conduct large-scale epidemiological studies. The plaque-reduction neutralization test (PRNT) is the reference-standard for quantifying antibodies capable of neutralizing SARS-CoV-2. However, the PRNT is logistically demanding, time-consuming, and requires containment level-3...
In silico study of the potential interactions of 4'-acetamidechalcones with protein targets in SARS-CoV-2 - The sanitary emergency generated by the pandemic COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 20 million people were reported with the infection. Of these, more than 740,000 died. In view of the situation, strategies involving the development of new antiviral molecules are extremely important. The present work...
Dexamethasone inhibits SARS-CoV-2 spike pseudotyped virus viropexis by binding to ACE2 - The SARS-CoV-2 outbreak, began in late 2019, has caused a worldwide pandemic and shows no signs of slowing. Glucocorticoids (GCs), including dexamethasone (DEX), have been widely used as effective anti-inflammatory and immunosuppressant drugs. In this study, seven GCs had no obvious effect on cell viability of angiotensin converting enzyme 2 (ACE2) high expressed HEK293T cells when concentrations were under 10 μM. Molecular docking results revealed that DEX occupied with active binding site of...
Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine - CONCLUSIONS: These preclinical findings support clinical investigation of the repurposing of CPZ, a largely used drug with mild side effects, in COVID-19 treatment.
Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulations - The COVID-19 pandemic has spread rapidly and posed an unprecedented threat to the global economy and human health. Broad-spectrum antivirals are currently being administered to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). China's prevention and treatment guidelines suggest the use of an antiinfluenza drug, arbidol, for the clinical treatment of COVID-19. Reports indicate that arbidol could neutralize SARS-CoV-2. Monotherapy with arbidol is found to be superior to...
Covid 19 - Chewing Gum - - link
A traditional Chinese medicine composition for COVID-19 and/or influenza and preparation method thereof - - link
STOCHASTIC MODEL METHOD TO DETERMINE THE PROBABILITY OF TRANSMISSION OF NOVEL COVID-19 - The present invention is directed to a stochastic model method to assess the risk of spreading the disease and determine the probability of transmission of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
The use of human serum albumin (HSA) and Cannabigerol (CBG) as active ingredients in a composition for use in the treatment of Coronavirus (Covid-19) and its symptoms - - link
"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2." - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex. - link
제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물 - 본 발명은 화학식 1로 표시되는 화합물, 또는 이의 약학적으로 허용가능한 염; 및 글루카곤 수용체 작용제(glucagon receptor agonist), 위 억제 펩타이드(gastric inhibitory peptide, GIP), 글루카곤-유사 펩타이드 1(glucagon-like peptide 1, GLP-1) 및 글루카곤 수용체/위 억제 펩타이드/글루카곤-유사 펩타이드 1(Glucagon/GIP/GLP-1) 삼중 완전 작용제(glucagon receptors, gastric inhibitory peptide and glucagon-like peptide 1 (Glucagon/GIP/GLP-1) triple full agonist)로 이루어진 군으로부터 선택된 1종 이상;을 포함하는 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환 예방 또는 치료용 약학적 조성물을 제공한다. - link
Haptens, hapten conjugates, compositions thereof and method for their preparation and use - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels. - link
SARS-CoV-2 RBD共轭纳米颗粒疫苗 - 本发明涉及免疫医学领域，具体而言，涉及一种SARS‑CoV‑2 RBD共轭纳米颗粒疫苗。该疫苗包含免疫原性复合物，所述免疫原性复合物包含：a）与SpyCatcher融合表达的载体蛋白自组装得到的纳米颗粒载体；b）与SpyTag融合表达的SARS‑CoV‑2病毒的RBD抗原；所述载体蛋白选自Ferritin、mi3和I53‑50；所述载体蛋白与所述抗原之间通过SpyCatcher‑SpyTag共价连接。 - link
Устройство электронного контроля и дистанционного управления аппарата искусственной вентиляции легких - Полезная модель относится к медицинской технике, а именно к устройствам для воздействия на дыхательную систему пациента смесью различных газов, в частности, к устройствам для проведения искусственной вентиляции легких (ИВЛ). Технический результат предлагаемой полезной модели заключается в решении технической проблемы, состоящей в необходимости расширения арсенала технических средств, предназначенных для электронного контроля и управления ИВЛ, путем реализации возможности дистанционного управления аппаратами ИВЛ в медицинских учреждениях, не оборудованных кабельными вычислительными сетями. Указанный технический результат достигается благодаря тому, что в известное устройство электронного контроля и дистанционного управления аппарата ИВЛ, содержащее центральный микроконтроллер, а также программно-аппаратные средства управления функциями доставки воздушной смеси пациенту и многоуровневой тревожной сигнализации об отклонениях от нормативных условий и технических неполадках в аппарате ИВЛ, введены связанные друг с другом микроконтроллер связи и дистанционного управления и радиомодем, выполненный с возможностью связи с точками доступа радиканальной сети, при этом центральный микроконтроллер устройства выполнен с дополнительными входом/выходом, которые связаны с управляющими выходом/входом микроконтроллера связи и дистанционного управления, а, в зависимости от типа применяемой в медицинском учреждении радиоканальной сети связи и передачи данных, радиомодем может быть выполнен в виде интерфейсного аудиомодуля Bluetooth 4.0 BLE, приемопередающего модуля Wi-Fi либо устройства "малого радиуса действия", работающего по технологии LoRa на нелицензируемых частотах мегагерцового диапазона, например, в диапазоне 868 МГц. 3 з.п. ф-лы, 1 ил. - link
What the San Francisco Bay Area Can Teach Us About Fighting a Pandemic - The region’s hyper-local response has lessons for us as we confront the winter wave and begin to distribute vaccines. - link
Can Boosting Child and Elder Care Help Democrats Win Control of the Senate? - Groups canvassing in Georgia say that the “care economy” is a pivotal issue to voters. - link
Can Democrats Win Georgia—and the Senate? - In order to do so, the candidates will need high voter turnout in a state where it tends to drop during runoffs, especially among the Party’s own supporters. - link
The Real Republican Radicals - The Trump movement was long understood as a populist one. But, since the election, the people at the barricades have been politicians and their lawyers. - link
Dr. Anthony Fauci on Becoming an Activist Within Government - America’s top infectious-disease expert discusses how governments can respond to save lives in pandemics. - link
++Pelosi will lead a slim Democratic House majority in the 117th Congress. +
++California Democratic Rep. Nancy Pelosi has been elected to another term — her fourth — as speaker of the House of Representatives, one she has promised will be her last. +
++By a vote of 216 to 209 Sunday, with three members voting present and several others either absent or voting for other candidates, Democratic lawmakers once again gave Pelosi the gavel just hours after the historically diverse 117th Congress was sworn in. +
++Pelosi, 80, previously made history as the first woman to be elected speaker, and she has again made history on Sunday by becoming the oldest American to be elected to the role. Renowned House Speaker Sam Rayburn of Texas, who previously held that honor, was 78 when elected for his final term. +
++Pelosi faced no challengers, but had little margin for error given her party’s slender majority in the new Congress. Despite having expected to expand their majority in the 2020 elections, Democrats actually lost ground and now hold just 222 seats in the chamber — four more than the 218 needed for a bare majority — with two races still undecided. In total, the GOP picked up at least nine seats. +
++To retain the speakership, Pelosi needed only to receive a simple majority of votes in the full House. But she faced questions over whether she would be able to achieve that majority. +
++Among other issues, several Democratic House members — such as Wisconsin Rep. Gwen Moore — have tested positive for the coronavirus in recent weeks. Moore ultimately ended up voting on the House floor anyway, despite not having tested negative for Covid-19 since her positive test on December 28. +
++The absence of two Republican representatives-elect because of positive Covid-19 tests — David Valadao of California and Maria Elvira Salazar of Florida — also made the math somewhat easier for Pelosi. +
++Nonetheless, there was concern that, as in 2018, Pelosi would face opposition to her bid from within the Democratic Party — and that this time it might be enough to derail her chances. +
++After the 2018 midterms, more than a dozen Democrats opposed another speaker’s term for Pelosi, arguing that their party needed new leadership. Some of those who were against Pelosi then, like former New York Rep. Max Rose, lost reelection; others, like Pennsylvania’s Rep. Conor Lamb, remain in the House. Ahead of Sunday’s vote, there were lingering questions about how these lawmakers — as well as first-term members who had been silent about their intentions — might vote on Sunday. +
++Lamb voted for New York Rep. Hakeem Jeffries, the chair of the House Democratic Caucus, on Sunday. +
++But Jeffries himself was confident about Pelosi’s chances ahead of the vote Sunday, telling Fox News, “Nancy Pelosi will be the next speaker of the United States House of Representatives and I look forward to placing her name into nomination.” +
++And Virginia Rep. Gerry Connolly suggested to CNN that concerns about Pelosi’s ability to secure majority support were overblown, saying, “If Nancy can do anything, it is that she knows how to count.” +
++Ultimately, Pelosi was able to marshal enough votes to stay in power, with previously undeclared first-term members like New York Rep. Jamaal Bowman choosing to support her for a fourth term as speaker. +
++However, the 117th Congress will likely be Pelosi’s last as speaker. In 2018, she struck a deal with Democrats who opposed her run — promising that she would abide by proposed term limits for House leadership, meaning she would be able to serve only four more years. +
++Now that she has secured her position as speaker, Pelosi will face the early challenge of her majority dwindling even further, albeit likely just temporarily. +
++At least three House Democrats — Reps. Cedric Richmond, Marcia Fudge, and Deb Haaland — have been tapped for jobs in the Biden administration, leaving their seats vacant. (Richmond, who is in line to serve as director of the White House Office of Public Engagement, does not need to be confirmed for the job, though Fudge and Haaland do.) +
++All three currently serve in comfortably Democratic districts which are likely to remain blue if their current occupants leave for a Biden administration — but the seats will take time to fill, temporarily leaving Pelosi with as few as 219 Democratic votes. +
++Even once those seats are filled — assuming they are won by Democrats, as is likely — Pelosi will have to find a way to govern an occasionally fractious, diverse caucus and pass legislation with fewer votes to spare than she had in the last Congress. Unless she wins Republican votes, which is an unlikely prospect when it comes to many Democratic legislative priorities, she’ll be able to lose just four votes. +
++And Pelosi will preside over a deeply divided caucus — a split that was evident in the days immediately following the election, in which moderate members blamed progressives for losses, and that saw progressives call for even bolder action on issues like immigration and education. +
++The need for nearly every vote from both sides of the caucus will give individual members a greater ability to force compromises on legislation, a fact Washington Rep. Pramila Jayapal, chair of the Congressional Progressive Caucus, acknowledged recently. +
++“Anytime you have a very narrow majority it gives a lot of different parts of the caucus power. Progressives will have power but so will more conservative Democrats. So this will have to be a case where we are thoughtful, careful on how and when we weigh in on things and work as much as we can across the caucus as well,” Jayapal told Newsweek in December. +
++However, it’s not all bad news for Pelosi. For the first time since she yielded the speaker’s gavel in January 2011 following a Republican wave in the 2010 midterm elections, she will have an ally in the White House in the form of President-elect Joe Biden. What’s more, should Democrats win a pair of Senate runoffs in Georgia this week, the Democratic Party could enjoy unified control of the government for the first time since January 2011. +
++If Democratic Senate nominees Jon Ossoff and Rev. Raphael Warnock win out against incumbent Republican Sens. David Perdue and Kelly Loeffler Tuesday, Vice President-elect Kamala Harris will become the tie-breaking vote on January 20, tipping control of the chamber to the Democratic Party and making New York Sen. Chuck Schumer the majority leader. +
+
++Trump told the Georgia official: “I just want to find 11,780 votes.” +
++President Donald Trump asked Georgia Secretary of State Brad Raffensperger, a Republican, to “find” almost 12,000 nonexistent votes during a Saturday phone call, according to a report by Amy Gardner of the Washington Post. Inventing those votes would change the outcome of the election in that state, tipping its electoral votes to Trump over President-elect Joe Biden. +
++Over the course of a more than hour-long phone call, a recording of which was obtained by the Post, Trump raised a series of baseless, debunked conspiracy theories — and variously cajoled and threatened Raffensperger to find some way to award him the victory in Georgia, a state Trump lost by 11,779 votes. +
++“All I want to do is this,” Trump told Raffensperger on the call. “I just want to find 11,780 votes, which is one more than we have. Because we won the state.” +
++Ryan Germany, the general counsel to the Georgia secretary of state’s office, was also on the call, according to the Post, as were White House chief of staff Mark Meadows and conservative lawyer Cleta Mitchell. +
++Trump had earlier acknowledged the call in a tweet, but framed it very differently, claiming the men spoke about allegations of election fraud, which Raffensperger has disproven several times. Sunday’s Washington Post story reveals what was discussed in far more detail. +
++“I spoke to Secretary of State Brad Raffensperger yesterday about Fulton County and voter fraud in Georgia,” Trump tweeted Sunday morning. “He was unwilling, or unable, to answer questions such as the ‘ballots under table’ scam, ballot destruction, out of state ‘voters’, dead voters, and more. He has no clue!” +
++++I spoke to Secretary of State Brad Raffensperger yesterday about Fulton County and voter fraud in Georgia. He was unwilling, or unable, to answer questions such as the “ballots under table” scam, ballot destruction, out of state “voters”, dead voters, and more. He has no clue! +
+— Donald J. Trump (@realDonaldTrump) January 3, 2021 +
+Audio from the full 62-minute call was published by the Post Sunday, including an exchange where Trump threatens Raffensperger and Germany with imminent legal consequences should they fail to overturn the already certified results. +
++“That’s a criminal offense,” Trump tells Raffensperger and Germany on the call, apparently in reference to Raffensperger not reporting made-up instances of election fraud. “And you can’t let that happen. That’s a big risk to you and to Ryan, your lawyer. And that’s a big risk.” +
++Trump also raised a number of conspiracy theories resembling those promoted by onetime Trump lawyer Sidney Powell, who was cut loose by the Trump campaign’s legal team as her election fraud allegations became increasingly outlandish. +
++Powell, who has pushed a series of election lawsuits with scant — and sometimes purely fictitious — evidence of fraud. She has also repeatedly falsely asserted that voting machines designed by Dominion Voting Systems helped to steal the 2020 election from Trump. +
++In reality, President-elect Joe Biden won the 2020 presidential election by 306 electoral votes to Trump’s 232, and with a popular vote margin of more than 7 million votes. Recounts in battleground states like Georgia and Wisconsin — both won by Biden — have turned up no evidence of large-scale fraud or irregularities that could have affected the results of the election. +
++In all 50 states and Washington, DC, the election results have been carefully reviewed by state officials and certified as accurate. And Dominion’s machines have been found to have operated correctly. +
++Nonetheless, Trump aired a version of the Dominion conspiracy during his Saturday call. +
++“Now, do you think it’s possible that they shredded ballots in Fulton County?” Trump asked Germany on the call. “Because that’s what the rumor is. And also that Dominion took out machines. That Dominion is really moving fast to get rid of their machinery. Do you know anything about that? Because that’s illegal, right?” +
++As Germany affirmed on the call, none of Trump’s allegations are true. +
++Despite the Trump legal team’s move to disavow Powell, Trump has reportedly remained enamored with her theories. According to a New York Times report from December, he briefly considered naming Powell as special counsel to investigate his baseless claims of voter fraud, though he was ultimately talked down by aides. +
++And as recently as Sunday, he retweeted a message from Powell alleging — again, without even a shred of evidence — “massive fraud.” +
++++This “election” was stolen from the voters in a massive fraud that you & others are now complicit in. American elections are supposed to be completely auditable and transparent. #WeThePeople demand the Truth & the prosecutions of all who committed voter fraud. @realDonaldTrump https://t.co/Gd4vNmGxHV +
+— Sidney Powell ⭐⭐⭐ #Kraken (@SidneyPowell1) January 3, 2021 +
+According to the Washington Post, Trump’s remarks on the call Saturday raise the possibility of additional legal problems for a president already facing quite a few potential criminal investigations upon leaving office. The report noted, however, that there is no clear-cut offense revealed on the call and that any possible charges would ultimately be “subject to prosecutorial discretion.” +
++As CNN reporter Ryan Struyk pointed out on Twitter Sunday, US law makes it a crime to “‘knowingly and willfully ... attempt to deprive or defraud the residents of a State of a fair and impartially conducted election process’ by ‘the procurement ... of ballots that are known by the person to be materially false.’” +
++++52 US Code §20511 makes it illegal to "knowingly and willfully... attempt to deprive or defraud the residents of a State of a fair and impartially conducted election process" by "the procurement... of ballots that are known by the person to be materially false." +
+— Ryan Struyk (@ryanstruyk) January 3, 2021 +
+Trump may also have landed himself in legal peril at the state level. According to Politico reporter Kyle Cheney, “conspiracy to commit election fraud” and “criminal solicitation to commit election fraud” are both crimes in Georgia, and some legal experts believe Trump’s comments Saturday violated state law. +
++Other reporters, such as Business Insider’s Grace Panetta, have pointed out that Trump’s comments are strikingly similar to those he was impeached over in late 2019, after his pressure campaign against the president of Ukraine seeking to extort an investigation into Biden and his son, Hunter Biden, came to light. +
++++This is shockingly similar to what Trump was impeached over https://t.co/gqV2llatQu +
+— Grace Panetta (@grace_panetta) January 3, 2021 +
+In a statement Sunday, a Biden adviser condemned Trump’s election pressure campaign. +
++“We now have irrefutable proof of a president pressuring and threatening an official of his own party to get him to rescind a state’s lawful, certified vote count and fabricate another in its place,” former Obama White House counsel and current Biden senior adviser Bob Bauer said. +
++Though Sunday’s Washington Post scoop provides arguably the starkest example of Trump’s long-running attempts to subvert democracy in order to remain in power — not to mention a more than passing resemblance to President Richard Nixon’s presidency-ending tapes — it is by no means the only time Trump has mounted an effort of this sort since losing reelection. +
++In at least three other battleground states that he lost to Biden — Arizona, Michigan, and Pennsylvania — Trump has directly reached out to lawmakers and other officials to urge them to help him overturn the election results in their states, potentially awarding him an unelected second term in office. +
++In Pennsylvania, one Republican lawmaker — state Senate Majority Leader Kim Ward — told the New York Times that she chose not to push back on Trump’s baseless fraud accusations. +
++“If I would say to you, ‘I don’t want to do it,’” she said in December, “I’d get my house bombed tonight.” +
++But Trump’s antidemocratic efforts have been most acute in Georgia — possibly because the state remains in the news this month, more than 60 days after the presidential election, in the run-up to two crucial Senate runoffs this Tuesday that will decide partisan control of the chamber. +
++In his call Saturday, Trump suggested that this was the case to Raffensperger. +
++“You have a big election coming up and because of what you’ve done to the president — you know, the people of Georgia know that this was a scam,” Trump said on the call. “Because of what you’ve done to the president, a lot of people aren’t going out to vote, and a lot of Republicans are going to vote negative, because they hate what you did to the president.” +
++Georgia voters set a record for early-voting turnout ahead of Tuesday’s runoffs, according to the Atlanta Journal-Constitution, with more than 3 million votes cast ahead of Election Day on January 5. But as Vox’s Aaron Rupar has written, there are some indications Trump’s efforts to spread doubt about the security of the election may have depressed Republican participation so far. +
++And Republicans are likely to need every vote to ensure victories in both races. Polling suggests that both races are more or less a toss-up: According to FiveThirtyEight’s polling averages, Democratic Senate candidates Jon Ossoff and Rev. Raphael Warnock lead incumbent Republican Sens. David Perdue and Kelly Loeffler by around 2 percentage points each. +
++Trump will be back in Georgia on Monday for a final preelection rally, though if his last Georgia rally is any indication, he will likely stray to other topics, such as his grievances against Raffensperger and Georgia Gov. Brian Kemp. +
++“You would be respected, really respected if this thing could be straightened out before the election,” Trump told Raffensperger on the call Saturday. “You have a big election coming up on Tuesday.” +
++To date, Raffensperger has resisted Trump’s efforts to overturn the election, and Sunday, responded to Trump’s characterization of the call by tweeting, “Respectfully, President Trump: What you’re saying is not true. The truth will come out.” +
+
++Democrats face a narrow House majority, with control of the Senate to be decided in two Georgia runoff elections. +
++A historic new Congress was sworn in on Sunday, one that narrowed the margin of control in both chambers and brought a diverse class of first-term members to Capitol Hill. +
++In the House of Representatives, a previously robust Democratic majority shrank to just 222 seats — four more than the 218 needed for a bare majority — with two races still undecided, for a net GOP pickup of nine seats. +
++One Republican House member, Iowa Rep. Mariannette Miller-Meeks, was seated provisionally, as her opponent continues to contest Miller-Meeks’s six-vote margin of victory, and New York’s 22nd Congressional District will be temporarily without a representative as incumbent Rep. Anthony Brindisi’s race remains too close to call. +
++And another House district in Louisiana will remain vacant for the time being after the sudden death of Representative-elect Luke Letlow from Covid-19 complications last week. Letlow, 41, had won a runoff in Louisiana’s Fifth Congressional District; now, a special election will be held to fill his seat. +
++Despite Letlow’s tragic death, adherence to the House’s mask policy was a flashpoint Sunday as new members were sworn in: At least two new Republican members clashed with House staff on the issue Sunday, according to Punchbowl News’s Jake Sherman. +
++++2 new Republicans — including @mtgreenee — are being told by House floor staff that they have to put their masks on. as of now, they seem to be telling the floor staff that they will not put it on.
+— Jake Sherman (@JakeSherman) January 3, 2021 +
Taylor Greene is leaving the floor with the other R, who were trying to ID +
+The Republican Senate majority, meanwhile, dwindled slightly to just 51 seats ahead of a pair of decisive runoffs in Georgia this Tuesday. That’s down from Senate Majority Leader Mitch McConnell’s 53-seat margin for most of the 116th Congress, a majority that fell briefly to just 52 seats last month after Arizona Sen. Mark Kelly, a Democrat, was sworn in on December 2 following his special-election victory. +
++The Georgia runoffs mean that the Senate seat previously belonging to incumbent Sen. David Perdue will temporarily stand vacant between Sunday and the January 5 election, though Sen. Kelly Loeffler, who is facing a special election runoff, will retain hers at least through January 5. +
++Beyond Kelly winning a seat previously held by Republican Sen. Martha McSally, two other Senate seats changed hands in November, with Democratic Sen. John Hickenlooper ousting incumbent Republican Sen. Cory Gardner in Colorado and Republican Sen. Tommy Tuberville defeating incumbent Democrat Sen. Doug Jones in Alabama. However, given the affiliations of both victors, those elections will have no effect on the chamber’s overall balance of power. +
++In addition to the partisan changes, the 117th Congress has ushered in a number of demographic firsts. +
++In the House, Rep. Mondaire Jones (D-NY) became the first openly gay Black man to serve in Congress, while Democrat New York Rep. Ritchie Torres became the first openly gay Afro-Latino member. +
++Rep. Stephanie Brice (R-IA) is now the first Iranian-American person in Congress. +
++Reps. Marilyn Strickland (D-WA), Young Kim (R-CA), and Michelle Steel (R-CA) are the first Korean-American women in Congress. +
++And at just 25 years old, Rep. Madison Cawthorn (R-NC) is the youngest person to serve in Congress in the modern era, according to CNN. +
++The new House also includes more women than ever, breaking a record set by the 116th Congress. Of the 118 women in the House, 89 are Democrats and 29 Republicans. +
++Another notable first is the presence of two open supporters of the viral QAnon conspiracy theory, which posits the existence of a global cabal of Satanic pedophiles and which has been repeatedly amplified by President Donald Trump. +
++The FBI has labeled QAnon a domestic terrorism threat, and the conspiracy, which counts among its adherents Reps. Marjorie Taylor Greene (R-GA) and Lauren Boebert (R-CO), has been linked to multiple real-world acts of violence, including at least one murder. +
++In addition to swearing in new members, the House will also elect a new speaker Sunday. Rep. Nancy Pelosi (D-CA), who reclaimed the gavel after the 2018 midterms, is expected to win another term in the job, though she’ll have little margin for error with a slender new majority. +
++Pelosi, 80, has led the House Democratic caucus for 17 years and must receive a simple majority of votes in the full House to retain the speakership. A handful of Democrats have already signaled they plan to refuse to back Pelosi’s bid, but likely not enough to derail Pelosi’s bid for the gavel. +
++However, the 117th Congress will likely be Pelosi’s last as speaker. In 2018, she struck a deal with fellow Democrats in the House that she would only seek two more years in the job, according to CNN. +
++Should she again become speaker, Pelosi will face the early challenge of her majority dwindling even further, albeit likely just temporarily. At least three House Democrats — Reps. Cedric Richmond, Marcia Fudge, and Deb Haaland — have been tapped for jobs in the Biden administration, leaving their seats vacant. (Richmond, who is in line to serve as director of the White House Office of Public Engagement, does not need to be confirmed for the job, though Fudge and Haaland do.) +
++All three currently serve in comfortably Democratic districts which are likely to remain blue if their current occupants leave for a Biden administration — but the seats will take time to fill, temporarily leaving Pelosi with as few as 219 Democratic votes. +
++In the Senate, McConnell’s slim majority — and thus his tenure as majority leader in the 117th Congress — could prove ephemeral, depending on how Tuesday’s high-stakes Georgia runoffs shake out. +
++With two days until voters head to the polls in Georgia, incumbent Republicans Perdue and Loeffler both trail their respective Democratic challengers — Jon Ossoff and Rev. Raphael Warnock — by less than 2 percentage points, according to FiveThirtyEight’s polling average, making both of the races essentially toss-ups. +
++Biden won the state in November this year, becoming the first Democratic presidential candidate to win in Georgia since 1992, and Trump has focused much of his ire over his election loss on Georgia Secretary of State Brad Raffensperger and Georgia Gov. Brian Kemp. +
++If Democrats win both races, however, that will boost their margin in the chamber to 50 seats (counting independent Sens. Bernie Sanders and Angus King, who caucus with Senate Democrats). With the inclusion of Vice President-elect Kamala Harris, who could become the tie-breaking vote once she’s sworn in on January 20, Democrats would hold the majority for the first time since the 113th Congress, which ended in January 2015. +
++Warnock’s victory would be particularly historic: If he wins, he will be the first Black senator ever elected in the state of Georgia. +
++If either Perdue or Loeffler, or both, win reelection, though, McConnell will hold onto the majority, and President-elect Joe Biden is likely to find working with the Senate much more difficult. +
+Tokyo Olympics | Hopeful of India recording best-ever medal haul: Abhinav Bindra - is optimistic about a strong performance by the Indian shooting contingent
Cricket Australia rejects reports of India seeking to shift fourth Test out of Brisbane - Nick Hockley said the Indian cricket board was ‘fully across (and) supportive’ of quarantine requirements in Queensland.
New Zealand vs Pakistan, 2nd Test, Day 2 | Williamson's 112 helps New Zealand cut Pakistan's lead - Williamson's century was his 24th in Tests and again came at a crucial time for New Zealand
We should be mentally prepared for several challenges on way to Olympics: Manpreet - With only 200 days to go for the Olympics, Manpreet and Rani, believe the players in respective core groups will have to give their 100% to be able to achieve their goals
Aus vs Ind | Australia pacer James Pattinson ruled out of third Test against India with bruised ribs - A replacement has not been named for James Pattinson, who got injured after a fall at home
Trinamool leader alleges lack of fund allocation by Railways - West Bengal minister Sashi Panja says the Railways had in 2019 allocated a token of ₹1,000 for many "pro-people" projects.
306-km waterway to be made navigable from next month - 68-km Vallakadavu-Kollam stretch, 70-km Kottapuram-Chavakkad stretch to be commissioned
New COVID-19 strain: Total 38 people in India test positive - These include the 29 cases which were announced till January 1
Goa Congress leader seeks SC direction to Speaker regarding disqualification of MLAs - The disqualification petition with the Speaker was filed in August 2019 and one-and-half year has gone by and a decision has still not been taken on it.
Parties hold meetings of newly elected GP members - Major political parties on Monday held meetings of newly elected members of Gram Panchayats to show their strength in Shivamogga district. BJP leaders
Coronavirus: French government vows to speed up vaccinations - A week into mass vaccinations France has inoculated fewer than 1,000 - far behind Germany.
Covid: Brian Pinker, 82, first to get Oxford-AstraZeneca vaccine - The PM says the number of vaccine doses will amount to "tens of millions" by the end of March.
Julian Assange: Wikileaks founder extradition to US blocked by UK judge - The Wikileaks founder is wanted in the US over the publication of thousands of classified documents.
Brexit: Fresh test for Irish Sea trade border processes - As businesses return to work after Christmas, the amount of freight moving through NI will increase.
Fiat Chrysler and PSA merger faces final hurdle - The deal will create the world's fourth biggest car maker and lead to major savings for the new group.
Study: Folklore structure reveals how conspiracy theories emerge, fall apart - Rumors swirling around 2016 Wikileaks dump was glue that held "Pizzagate" together. - link
My green home: $90,000 in clean tech upgrades, $20,000 in tax breaks - I bought solar panels, a heat pump, a condensing boiler, and an electric car. - link
Tesla delivered a record 500,000 vehicles in 2020 - Tesla needs to expand rapidly to justify its $600 billion market capitalization. - link
Archaeology is going digital to harness the power of Big Data - Combining traditional "pick and trowel" field work with a sweeping birds-eye view - link
You can’t unsee Tedlexa, the Internet of Things/AI bear of your nightmares - From the archives: Teddy Ruxpin + Arduino + Raspberry Pi + Alexa = What could go wrong? - link
+None, reports say he fell +
+ submitted by /u/Trianchorgen
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+"I know a simple trick,” Julia said.
“Whenever I want to have sex with Peter, I gently put my hand on his dick and say:
Your dick is very cold, do you want me to warm it up for you?
And that's it! Works every time!”
Anna was impressed, and said she would try it when her husband got home that night.
+
+When they met the next day, Julia asked how it went. Anna immediately started crying.
“We’re getting a divorce!” she sobbed.
“What? What happened?” Julia asked concerned.
“I tried to do your trick, but as I laid my hand on his dick, it was actually quite warm. I didn’t know what to say, so I asked him:
Why isn't your dick cold, like Peter’s?”
+
Edit: +Credit is due to u/Qandeel19, who posted this. +
++Thanks for all the awards and upvotes! Really made my day! +
+ submitted by /u/BinBender
[link] [comments]
+Nothing. There’s a vas deferens between the two. +
+ submitted by /u/vilketaventyr
[link] [comments]
+It was the first day of a school in USA and a new Indian student named Chandrasekhar Subramanian entered the fourth grade. +
++The teacher said: "Let's begin by reviewing some American History. +
++Who said 'Give me Liberty, or give me Death'?" +
++She saw a sea of blank faces except for Chandrasekhar who had his hand up: ’Patrick Henry, 1775' he said. +
++'Very good! Who said 'Government of the People, by the People, for the People, shall not perish 'from the Earth?'' +
++Again, no response except from Chandrasekhar. 'Abraham Lincoln, 1863' said Chandrasekhar. +
++The teacher snapped at the class: 'Class, you should be ashamed. Chandrasekhar, who is new to our country, knows more about our history than you do.' +
++She heard a loud whisper: 'F*** the Indians,' +
++'Who said that?' she demanded. +
++Chandrasekhar put up his hand. 'General Custer, 1862.' +
++At that point, a student in the back said: 'I'm gonna puke.' +
++The teacher glares around and asks: 'All right! Now, who said that?' +
++Again, Chandrasekhar says: 'George Bush to the Japanese Prime Minister, 1991.' +
++Now furious, another student yells: 'Oh yeah? Suck this!' +
++Chandrasekhar jumps out of his chair waving his hand and shouts to the teacher: 'Bill Clinton, to Monica Lewinsky, 1997' +
++Now with almost mob hysteria someone said: 'You little shit. If you say anything more, I'll kill you.' +
++Chandrasekhar frantically yells at the top of his voice: 'Michael Jackson to the child witnesses testifying against him, 2004.' +
++The teacher fainted. And as the class gathered around the teacher on the floor, someone said: 'Oh shit, we're screwed!' +
++And Chandrasekhar said quietly: 'I think it was Lehmann Brothers, November 4th, 2008' +
+ submitted by /u/Sachinksda
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+Cause it's fucking r/aww! +
++EDIT: Thanks for the dopamine hits, everyone! +
+ submitted by /u/ChewyNutCluster
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