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+ + + ++There is a public health need to understand how different frequencies of COVID-19 booster vaccines may mitigate the risk of severe COVID-19, while accounting for waning of protection and differential risk by age and immune status. By analyzing United States COVID-19 surveillance and seroprevalence data in a microsimulation model, here we show that more frequent COVID-19 booster vaccination (every 6-12 months) in older age groups and the immunocompromised population would effectively reduce the burden of severe COVID-19, while frequent boosters in the younger population may only provide modest benefit against severe disease. In persons 75+ years, the model estimated that annual boosters would reduce absolute annual risk of severe COVID-19 by 199 (uncertainty interval: 188-229) cases per 100,000 persons, compared to a one-time booster dose. In contrast, for persons 18-49 years, the model estimated that annual boosters would reduce this risk by 14 (11-19) cases per 100,000 persons. Those with prior infection had lower benefit of more frequent boosting, and immunocompromised persons had larger benefit. Scenarios with emerging variants with immune evasion increased the benefit of more frequent variant-targeted boosters. This study underscores the benefit of considering key risk factors to inform frequency of COVID-19 booster vaccines in public health guidance and ensuring at least annual boosters in high-risk populations. +
+Long COVID-19 [11C]CPPC Study - Conditions: COVID Long-Haul
Interventions: Drug: [11C]CPPC Injection; Drug: [11C]CPPC Injection
Sponsors: Johns Hopkins University; Radiological Society of North America
Not yet recruiting
Thrombohemorrhagic Complications of COVID-19 - Conditions: COVID-19 (Coronavirus Disease 2019)
Interventions: Diagnostic Test: Prevention algorithm
Sponsors: Volgograd State Medical University
Active, not recruiting
Combined Use of Immunoglobulin and Pulse Steroid Therapies in Severe Covid-19 Patients - Conditions: Pulse Steroid and Immunoglobulins Drugs in Covid 19 Patients
Interventions: Drug: pulse steroid and nanogam
Sponsors: Konya City Hospital
Completed
Beneficial Effects of Natural Products on Management of Xerostomia - Conditions: Xerostomia; Diabetes Mellitus; Hypertension; Post COVID-19 Condition
Interventions: Other: (Manuka honey-green tea- ginger)
Sponsors: British University In Egypt
Completed
Eficacia Ventilatoria y Remolacha - Conditions: SARS CoV 2 Infection; Muscle Disorder; Fatigue
Interventions: Dietary Supplement: Remolacha
Sponsors: Hospital de MatarĂł
Recruiting
Diet and Fasting for Long COVID - Conditions: Long Covid19; Long COVID
Interventions: Other: Low sugar diet and 10-12 hour eating window; Other: Low sugar diet, 8 hour eating window and fasting
Sponsors: Pacific Northwest University of Health Sciences
Recruiting
The Effectiveness of a Health Promotion Program for Older People With Post-Covid-19 Sarcopenia - Conditions: Post COVID-19 Condition
Interventions: Other: Protein powder and Resistance exercise
Sponsors: Mahidol University; National Health Security Office, Thailand
Not yet recruiting
Chronic-disease Self-management Program in Patients Living With Long-COVID in Puerto Rico - Conditions: Long Covid19
Interventions: Other: “Tomando control de su salud” (Spanish Chronic Disease Self-Management)
Sponsors: University of Puerto Rico; National Institutes of Health (NIH)
Recruiting
Treatment of Persistent Post-Covid-19 Smell and Taste Disorders - Conditions: Post-covid-19 Persistent Smell and Taste Disorders
Interventions: Drug: Cerebrolysin; Other: olfactory and gustatory trainings
Sponsors: Sherifa Ahmed Hamed
Completed
A Study to Evealuate Safety and Immunogenicity of TI-0010 SARS-CoV-2 Vaccine in Healthy Adults - Conditions: COVID-19; COVID-19 Immunisation
Interventions: Biological: TI-0010; Biological: Placebo
Sponsors: National Drug Clinical Trial Institute of the Second Affiliated Hospital of Bengbu Medical College; Therorna
Recruiting
Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L - Phosphodiesterases (PDEs) encoded by viruses are putatively acquired by horizontal transfer of cellular PDE ancestor genes. Viral PDEs inhibit the OAS-RNase L antiviral pathway, a key effector component of the innate immune response. Although the function of these proteins is well-characterized, the origins of these gene acquisitions are less clear. Phylogenetic analysis revealed at least five independent PDE acquisition events by ancestral viruses. We found evidence that PDE-encoding genes were…
Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations - The emergence of the COVID-19 situation has become a global issue due to the lack of effective antiviral drugs for treatment. Flavonoids are a class of plant secondary metabolites that have antiviral activity against SARS-CoV-2 through inhibition of the main protease (3CL^(pro)). In this study, 22 flavonoids obtained from natural sources and semisynthetic approaches were investigated for their inhibitory activity against SARS-CoV-2 3CL^(pro), along with cytotoxicity on Vero cells. The…
Triterpenoidal Saponins from the Leaves of Aster koraiensis Offer Inhibitory Activities against SARS-CoV-2 - Triterpenoidal saponins have been reported to be able to restrain SARS-CoV-2 infection. To isolate antiviral compounds against SARS-CoV-2 from the leaves of Aster koraiensis, we conducted multiple steps of column chromatography. We isolated six triperpenoidal saponins from A. koraiensis leaves, including three unreported saponins. Their chemical structures were determined using HR-MS and NMR data analyses. Subsequently, we tested the isolates to assess their ability to impede the entry of the…
Assessing Genomic Mutations in SARS-CoV-2: Potential Resistance to Antiviral Drugs in Viral Populations from Untreated COVID-19 Patients - Naturally occurring SARS-CoV-2 variants mutated in genomic regions targeted by antiviral drugs have not been extensively studied. This study investigated the potential of the RNA-dependent RNA polymerase (RdRp) complex subunits and non-structural protein (Nsp)5 of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to accumulate natural mutations that could affect the efficacy of antiviral drugs. To this aim, SARS-CoV-2 genomic sequences isolated from 4155 drug-naive individuals from…
An Investigation of Severe Influenza Cases in Russia during the 2022-2023 Epidemic Season and an Analysis of HA-D222G/N Polymorphism in Newly Emerged and Dominant Clade 6B.1A.5a.2a A(H1N1)pdm09 Viruses - In Russia, during the COVID-19 pandemic, a decrease in influenza circulation was initially observed. Influenza circulation re-emerged with the dominance of new clades of A(H3N2) viruses in 2021-2022 and A(H1N1)pdm09 viruses in 2022-2023. In this study, we aimed to characterize influenza viruses during the 2022-2023 season in Russia, as well as investigate A(H1N1)pdm09 HA-D222G/N polymorphism associated with increased disease severity. PCR testing of 780 clinical specimens showed 72.2% of them to…
Antivirals for Broader Coverage against Human Coronaviruses - Coronaviruses (CoVs) are enveloped positive-sense single-stranded RNA viruses with a genome that is 27-31 kbases in length. Critical genes include the spike (S), envelope (E), membrane (M), nucleocapsid (N) and nine accessory open reading frames encoding for non-structural proteins (NSPs) that have multiple roles in the replication cycle and immune evasion (1). There are seven known human CoVs that most likely appeared after zoonotic transfer, the most recent being SARS-CoV-2, responsible for…
Emerging Therapeutic Potential of Polyphenols from Geranium sanguineum L. in Viral Infections, Including SARS-CoV-2 - The existing literature supports the anti-inflammatory, antioxidant, and antiviral capacities of the polyphenol extracts derived from Geranium sanguineum L. These extracts exhibit potential in hindering viral replication by inhibiting enzymes like DNA polymerase and reverse transcriptase. The antiviral properties of G. sanguineum L. seem to complement its immunomodulatory effects, contributing to infection resolution. While preclinical studies on G. sanguineum L. suggest its potential…
Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway - Hyperphosphatemia or severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can promote cardiovascular adverse events in patients with chronic kidney disease. Hyperphosphatemia is associated with elevated inflammation and sterol regulatory element binding protein 2 (SREBP2) activation, but the underlying mechanisms in SARS‑CoV‑2 that are related to cardiovascular disease remain unclear. The present study aimed to elucidate the role of excess inorganic phosphate (PI) in SARS‑CoV‑2…
Quercetin inhibits SARS-CoV-2 infection and prevents syncytium formation by cells co-expressing the viral spike protein and human ACE2 - CONCLUSION: These findings suggest that at low 3-digit micromolar concentrations of quercetin could impair SARS-CoV-2 infection of human cells partly by blocking the fusion process that promotes its propagation.
The temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells - CONCLUSIONS: These results indicate that the temporal association of CapZ with EEs facilitates early-to-late endosome transition (physiologically) and the release of the viral genome from endocytic vesicles (pathologically).
Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome - The coronavirus disease 2019 (COVID-19) pandemic has heavily challenged the global healthcare system. Despite the vaccination programs, the new virus variants are circulating. Further research is required for understanding of the biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and for discovery of therapeutic agents against the virus. Here, we took advantage of drug repurposing to identify if existing drugs could inhibit SARS-CoV-2 infection. We established an…
Mechanistic Understanding of the Modes of Ca2+ Ion Binding to the SARS-CoV-1 Fusion Peptide and Their Role in the Dynamics of Host Membrane Penetration - The SARS-CoV-1 spike glycoprotein contains a fusion peptide (FP) segment that mediates the fusion of the viral and host cell membranes. Calcium ions are thought to position the FP optimally for membrane insertion by interacting with negatively charged residues in this segment (E801, D802, D812, E821, D825, and D830); however, which residues bind to calcium and in what combinations supportive of membrane insertion are unknown. Using biological assays and molecular dynamics studies, we have…
Pharmacokinetics of recombinant human annexin A5 (SY-005) in patients with severe COVID-19 - Objective: Annexin A5 is a phosphatidylserine binding protein with anti-inflammatory, anticoagulant and anti-apoptotic properties. Preclinical studies have shown that annexin A5 inhibits pro-inflammatory responses and improves organ function and survival in rodent models of sepsis. This clinical trial aimed to evaluate the pharmacokinetic (PK) properties of the recombinant human annexin A5 (SY-005) in severe COVID-19. Methods: This was a pilot randomized, double-blind, placebo-controlled trial….
Biosurfactant potential and antiviral activity of multistrain probiotics - The COVID-19 caused by the SARS-CoV-2 has become a great threat to humans. However, there is no recommendation for an effective and safe drug to treat the disease. The strategy developed in this study is to utilize biosurfactant potential activity of Lactobacillus spp. and Rhodopseudomonas palustris probiotics to prevent the virus from entering human body. The outer membrane of the virus is comprising of phospholipid compounds. Biosurfactants, are known to have detergent-like properties (able to…
Online Group Supervision as Pedagogy: A Qualitative Inquiry of Student Mental Health Nurses’ Discourses and Participation - This study explored online group clinical supervision participation, as a component of pre-registration education following mental health nursing students’ clinical placements. Clinical supervision has historically been valued as a supportive strategy by healthcare professionals to develop practice and competence and prevent burnout. As many student nurses do not have access to clinical supervision via practice areas as a standardised process, their experiences of engaging in or benefitting from…
How Senate Democrats Are Divided on Israel - Oregon Senator Jeff Merkley discusses Bernie Sanders’s failed resolution to condition U.S. military aid to Israel, and his visit to the Gaza border. - link
The Future of Academic Freedom - As the Israel-Hamas war provokes claims about unacceptable speech, the ability to debate difficult subjects is in renewed peril. - link
How to Eat a Tire in a Year, by David Sedaris - Walking and talking with my friend Dawn. - link
Sofia Coppola’s Path to Filming Gilded Adolescence - There are few Hollywood families in which one famous director has spawned another. Coppola says, “It’s not easy for anyone in this business, even though it looks easy for me.” - link
Rules for the Ruling Class - How to thrive in the power élite—while declaring it your enemy. - link
+National festivities this week danced on Indian secularism’s grave — and pointed to an existential threat to Indian democracy. +
++On Monday, tens of millions across India celebrated the opening of the Ram Mandir — a huge new temple to Ram, one of Hinduism’s holiest figures, built in the city of Ayodhya where many Hindus believe he was born. +
++The celebration in Ayodhya, presided over by Prime Minister Narendra Modi, attracted some of India’s richest and most famous citizens. But in the pomp and circumstance, few dwelled explicitly on the grim origins of Ram Mandir: It was built on the site of an ancient mosque torn down by a Hindu mob in 1992. +
++Many of the rioters belonged to the RSS, a militant Hindu supremacist group to which Modi has belonged since he was 8 years old. Since ascending to power in 2014, Modi has worked tirelessly to replace India’s secular democracy with a Hindu sectarian state. +
++The construction of a temple in Ayodhya is the exclamation point on an agenda that has also included revoking the autonomy long provided to the Muslim-majority state of Jammu and Kashmir, creating new citizenship and immigration rules biased against Muslims, and rewritten textbooks to whitewash Hindu violence against Muslims from Indian history. +
++Modi has also waged war on the basic institutions of Indian democracy. He and his allies have consolidated control over much of the media, suppressed critical speech on social media, imprisoned protesters, suborned independent government agencies, and even prosecuted Congress party leader Rahul Gandhi on dubious charges. +
++For many Hindus, the inauguration of the Ram Mandir was a meaningful religious event. But viewed from a political point of view, the event looks like a grim portrait of Modi’s India in miniature: a monument to an exclusive vision of Hinduism built on the ruins of one of the world’s most remarkable secular democracies. +
++Understanding the temple’s story is thus essential to understanding one of the most important issues of our time: how democracy has come under existential threat in its largest stronghold. +
++The dispute over Ayodhya has become a flashpoint in modern Indian politics because it speaks to a fundamental ideological question: Who is India for? +
++The relevant history here starts in the early 16th century, when a Muslim descendant of Genghis Khan named Babur invaded the Indian subcontinent from his small base in central Asia. Babur’s conquests inaugurated the Mughal Empire, a dynasty that would reign in what is now India, Pakistan, and Bangladesh for generations. At least a remnant of the Mughal state survived until the British seized India in the 19th century. +
++The mosque in Ayodhya was a product of the early Mughal Empire, with some evidence suggesting it was built almost immediately after Babur’s forces conquered Ayodhya in 1529. Called the Babri Masjid — literally “Babur’s Mosque” — it was a testament to the impact the Mughal dynasty and its Muslim rulers had on Indian history and culture. +
++During the British colonial period, different Indian factions diverged sharply on how to remember the Mughal empire. +
++For Mahatma Gandhi, who led the mainstream independence movement, the Moghul Empire was a testament to India’s history of religious diversity and pluralism. Gandhi praised the Moghul dynasty, especially its early leadership, for adopting religious toleration as a central state policy. “In those days, they [Hindus and Muslims] were not known to quarrel at all,” he said in 1931, blaming current sectarian tensions on British colonial policy. +
++But the leadership of the Hindu nationalist RSS organization saw things differently. Focusing in particular on the late Mughal emperor Aurangzeb — who imposed a special tax on non-Muslims and tore down Hindu temples — they argued that the Mughals were more like the British than Gandhi allowed. The Muslim dynasty was not, in their mind, an authentic Indian regime at all; it was just another colonial conquest of an essentially Hindu nation. Muslims could not, and should not, be seen as full and equal members of the polity. +
++The Babri Masjid swiftly became a major flashpoint for this historical and political dispute. Because Ayodhya was widely seen by Hindus as Ram’s birthplace, the presence of a prominent Mughal mosque there was seen as an affront by Hindu nationalists. In 1949, shortly after independence, a statue of Ram was discovered inside the mosque itself. Hindu nationalists claimed that this was a divine manifestation, proof that the mosque itself was the site where Ram was born. +
++But according to Hartosh Singh Bal, executive editor of the Indian news magazine The Caravan, the historical record tells a different story. +
++“Members of a Hindu right-wing organization clambered over the walls, took the idol, [and] placed it there,” Bal told Vox’s Today Explained. “This was the first supposed proof that this [site] was in any way connected to a Hindu monument.” +
++For years, this manufactured conflict over religion and the Mughal legacy didn’t play a major role in Indian politics. The Congress party, the political descendant of Gandhi’s secular liberal vision for India, dominated Indian politics — winning every single national election for the first 30 years of Indian independence. +
++But in the 1980s, as the public tired of the Congress party’s domination, Hindu nationalist efforts to stoke tension surrounding the mosque intensified — and caught political fire. The BJP, the political arm of the RSS, made the construction of a Hindu temple on the site of the Babri Masjid a central part of its political agenda. The party, which won just two seats in India’s parliament in 1984’s election, won 85 seats in the 1989 contest. +
+ ++The RSS and BJP kept pressing on the issue, helping organize a series of yatras (pilgrimages) to Ayodhya calling for the mosque’s demolition. These grew huge, unruly, and even violent. In 1992, an out-of-control Hindu nationalist mob armed with hammers and pickaxes stormed the Babri Masjid. They tore it down by hand, horrifying many Indians and setting off religious riots across India that killed thousands. +
++Andrea Malji, a scholar of Indian religious nationalism at Hawaii Pacific University, describes the Babri Masjid movement as creating a kind of “feedback loop.” By bringing widespread attention to a source of Hindu-Muslim conflict, the movement actually made Hindus and Muslims more afraid of each other — leading to more conflict between the groups and, thus, increasing support among Hindus for Hindu nationalism. This was very good for the BJP’s political fortunes. +
++“Mobilizing around identity — especially when you’re 80 percent of the country [as Hindus are] is an effective political strategy,” she tells me. +
++The Ayodhya dispute was not the only reason that, in the coming years, the BJP would displace Congress as the dominant party in Indian politics. Modi’s first national victory, in the 2014 election, owed more to economic issues and Congress’ many corruption scandals than anything else. +
++But Ayodhya was the crucible in which the BJP’s modern political approach was formed. Modi’s political innovation has been refining this approach, developing a brand of Hindu identity politics with greater appeal to the lower castes than the historically upper caste BJP had previously managed. As time has gone on, he has only gotten more aggressive in pushing his ideological agenda. +
++Through it all, the Ayodhya issue remained a major priority for both Modi and the BJP. In 2019, just months after Modi’s reelection, India’s Supreme Court ruled that the construction of Ram Mandir on the former site of the Babri Masjid could begin. Its inauguration this week is a declaration of victory for Modi and the BJP on one of their signature issues — one of the most visible in a long line of successes. +
++The Ayodhya dispute helps us understand a deeper connection between the rise of Modi-style populism and the erosion of Indian democracy — that anti-democratic politics is not some kind of bug in BJP rule, but an essential feature. +
++India’s constitution and founding documents unambiguously declare the country a secular nation of all of its citizens. This universalistic vision permeates Indian law and government; it lies at the heart of the Indian state. India’s founders believed this was essential to making the Indian state a viable democracy: There is no world in which the citizens of such a large and staggeringly diverse country could cooperate together if they weren’t guaranteed certain basic equal rights. +
++“We must have it clearly in our minds and in the mind of the country that the alliance of religion and politics in the shape of communalism is a most dangerous alliance,” Jawaharlal Nehru, India’s first prime minister, said in a 1948 speech. “The only right way for us to act is to do away with communalism in its political aspect in every shape and form.” +
++Modi’s Hindu nationalism, by contrast, posits that legitimacy flows not from consent of all the citizens but consent of true people of India. That means Hindus in general, and Hindu nationalists in particular. Because they believe they represent the true nation, Modi and the BJP have no problem steamrolling on the rights of those who disagree with them — including not just Muslims, but also Hindu critics in the press and checks and balances in the Indian state. +
++“It’s very difficult for me to find compatibility between Hindu nationalism and democracy,” says Aditi Malik, a political scientist at the College of the Holy Cross who studies Indian politics. +
++There is nothing in theory undemocratic about the construction of a Hindu temple on a recognized holy site, especially when the construction is duly authorized by the legal authorities. But when it’s built on the ruins of a mosque torn down by a Hindu nationalist mob aligned with the ruling government, it sends a signal not just of Hindu joy but of Muslim subordination by any means necessary. Notably, Modi did not, at any point during the ceremony, apologize to India’s Muslims for the violent way in which the road to Ram Mandir was paved. +
+ ++Milan Vaishnav, an India expert at the Carnegie Foundation for International Peace, sees this as exemplary of the BJP’s general approach to wielding power. In his view, the party has presided over a gradual breakdown of norms of restraint governing Indian politics — adopting an “ends justify the means” approach to imposing the Hindu nationalist agenda because they believe they speak for the true majority. +
++“There is this feeling that, because this government is democratically elected, whatever they do has a democratic imprimatur,” he says. +
++Modi’s war on the free press — which has included friendly oligarchs buying up independent media outlets, siccing auditors on critical media outlets, and even imprisoning reporters on terrorism charges — is a case in point. +
++Seeking to force the media to tow a friendly line is undemocratic under any definition, even if the policies are authorized by a legislative majority. But the BJP believes that it, and it alone, speaks on behalf of the Hindu nation — and that critics in the press have no more right to challenge them than Muslims do. +
++There is every reason to believe that India will continue following this anti-democratic path in the years to come. +
++Across India, Ram Mandir’s inauguration was widely seen as the beginning of Modi’s reelection campaign. With elections scheduled to begin sometime in the mid-to-late spring, Modi is previewing a campaign focused on his appeal as an almost godlike champion for Hindus. +
++“[The temple inauguration] bolsters an image of Mr. Modi as the champion of Indians abroad and Hindus at home; as someone who keeps his promises,” Manjari Chatterjee Miller, a senior fellow studying South Asia at the Council on Foreign Relations, tells me. “Expect much much more of this as election season gets underway.” +
++The consensus among India watchers is that Modi will win comfortably. The BJP is coming off three victories in December local elections, and the prime minister himself has an approval rating somewhere in the 70s. Whatever one’s opinion of Modi’s Hindu nationalism, there’s no doubt that it’s genuinely popular with hundreds of millions of Indians. +
++In evaluating India, we have to hold two thoughts in our heads at the same time. First, Modi and his agenda is genuinely popular with the Hindu majority. Second, this popularity has given him room to pursue an ideological agenda that imperils the long-term viability of Indian democracy. +
++When Modi said in his speech at Ayodhya that the day marks “the beginning of a new era,” this might very well be true. India could be at the beginning of a long illiberal night — one its democracy may not be able to survive. +
+Even without a ceasefire, the top UN court’s orders are a warning to Israel. +
++The International Court of Justice ruled Friday that Israel must increase its efforts to protect Palestinians and provide humanitarian aid to Gaza, though it did not call for an immediate ceasefire. +
++The ruling comes as part of a case South Africa brought against the Middle Eastern country, accusing it of committing genocide against the Palestinian people in its war in Gaza, which Israel launched in response to an October 7 attack by Hamas, the militant and political group that governs Gaza. The question of whether Israel is committing genocide remains open — proceedings in the case could continue for years — but South Africa had requested the court put a stop to the fighting as it weighs that possibility. +
++It doesn’t provide that injunction. But importantly, the court affirmed in Friday’s ruling that the court would still be hearing the genocide case, rather than dismissing it as Israel requested. And the Friday decision indicates the court believes Israel isn’t doing enough to prevent genocide against Palestinian people, nor is it sufficiently punishing incitement to genocide. +
++Still, the court’s decision indicates that the body finds it possible genocide is occurring or could in the future. +
++The six measures the ICJ issued are legally binding, meaning that under its treaty obligations under the 1948 Genocide Convention, Israel must do more to protect Palestinian civilians and prevent genocide. There would be few, if any, consequences if it ignores the ruling — as National Security Minister Itamar Ben-Gvir suggested Israel do — because the enforcement mechanism for the court’s orders is the notoriously political UN Security Council, in which the US, Israel’s strongest ally, has a permanent veto. +
++In short, the Friday ruling isn’t a clear victory for either side — but does suggest that South Africa’s claims are plausible. While little will likely change on the ground in the near term, the court’s decision has reinvigorated debate over the place of international law in conflict and imposed some boundaries on Israel’s prosecution of this war. +
++Israeli Prime Minister Benjamin Netanyahu responded to the interim ruling in a video message, the English version of which reiterates that Israel has a right to defend itself and calls South Africa’s request for a ceasefire “vile” and “blatant discrimination against the Jewish state” while insisting that “Israel’s commitment to international law is unwavering” and that it will continue to facilitate humanitarian aid to Gaza. However, as Times of Israel journalist Amy Spiro noted on X, his Hebrew message made no such promise. +
++South Africa suggested that the best way for Israel to comply with the court would be to stop its Gaza operations. “I believe that in exercising the order, there would have to be a ceasefire,” South African Foreign Minister Naledi Pandor said during a news conference following the announcement. +
++South Africa first filed the accusations against Israel on December 29, requesting an urgent hearing for a preliminary ruling. That means that Friday’s decision isn’t a case decided on the merits — that could be a years-long process, and it will decide if Israel is committing genocide against Palestinians, or if the state is guilty of violating other tenets of the Genocide Convention in prosecuting this war. +
++The ICJ has decided that any state — South Africa, in this case, a country with unique historical ties to the Palestinian cause — can make a complaint against another that it suspects of violating the Genocide Convention, even if the accusing state isn’t party to the conflict precipitating the alleged or potential genocide. +
++Israel has argued that its actions over the past three months — killing more than 25,000 Palestinians, imposing siege conditions in Gaza, forcibly displacing a million people, bombing UN facilities and hospitals, and destroying much of northern Gaza — do not indicate genocidal intent. Rather, these horrors, which ICJ President Joan Donoghue listed in detail while reading the ruling, are unfortunate but necessary collateral damage as it pursues Hamas militants. +
++Genocide is extremely difficult to prove, since there must be intent to destroy an ethnic group in whole or in part for an atrocity to be considered genocide. But at this stage, it was not necessary to prove intent — just that it’s possible genocide is occurring and that Israel isn’t doing enough to prevent it or to punish incitement to genocide. +
++As Adil Haque, a professor of international law at Rutgers University, said in a panel put on by the University of Wollongong in Australia, “the heart of South Africa’s case is first the complete siege on Gaza, followed by severe restrictions on humanitarian assistance,” not necessarily Israel’s relentless bombing campaign. Per South Africa’s argument, that Israel “has systematically destroyed the health and food systems of Gaza,” it “has created the humanitarian crisis that now creates the risk of group destruction.” +
++Though the ICJ put limits on how Israel can continue its war, it didn’t explain its reason for not calling for a ceasefire. It could be because the court doesn’t have jurisdiction over Hamas, a non-state actor, and can’t require the group to abide by the ceasefire. But the decision “is kind of indirectly indicating that Israel did have the right to defend itself militarily against what Hamas had done,” Jocelyn Getgen Kestenbaum, who directs the Benjamin B. Ferencz Human Rights and Atrocity Prevention Clinic and the Cardozo Law Institute in Holocaust and Human Rights (CLIHHR), told Vox. Even so, “that doesn’t mean that [Israel] can proportionately respond with war crimes and/or crimes against humanity.” +
++The court’s decisions are legally binding but difficult to enforce. Countries do ignore the ICJ’s orders — Russia, for example, ignored the court’s 2022 preliminary ceasefire order after its invasion of Ukraine, with no externally imposed consequences. +
++South Africa and Israel are obligated to follow the court’s orders in this case because they’re party to the 1948 Genocide Convention. If they don’t, they are violating that treaty. The ICJ is the court of the United Nations, and its enforcement mechanism is the UN Security Council, which can pass resolutions requiring Israel to do more to punish those who incite genocide, for instance, or who prevent humanitarian aid from reaching Gaza. +
++The US — one of the five permanent members of the Security Council — has historically vetoed any measure it sees as antagonistic toward Israel. Even if that weren’t the case, the Security Council is highly politicized and fractious, limiting its ability to enforce any resolution. +
++On Thursday before the ruling, State Department spokesperson Vedant Patel confirmed that the US is standing by Israel, including by rejecting claims that Israel is committing genocide, and there’s no evidence the two countries’ longstanding alliance is in any danger. “I doubt this will directly affect either US arms transfers or US actions at the UN regarding a ceasefire,” Brian Finucane, senior adviser for International Crisis Group’s US Program, told Vox. +
++Though it won’t stop the war, Friday’s decision “will definitely create a more pressured environment for Israel to operate in,” Juliette McIntyre, a lecturer in law at the University of South Australia, told Vox. It’s illegal for Israel’s allies, including the US, to “aid or assist in the commission of other wrongful acts (i.e., genocide),” she said, which could cause some partners to “withdraw military or other support for Israel in order to avoid this. States also have a duty to prevent genocide — which they may take more seriously once the Court has established that it’s a plausible risk.” +
++The court is also requiring Israel to submit a report within one month detailing its adherence to the interim orders. As Haque told Vox in an interview, that “might turn out to be significant, because Israel would have to convince the court that it’s abided by these orders. The court’s obviously going to make its own judgment and based on the tone of today’s reading, I think the court is going to scrutinize Israel’s representations about its degree of compliance.” +
++Even without a strong enforcement mechanism, the court is at the very least a venue for accountability: The ongoing genocide case can be used by other international bodies, like the International Criminal Court, in their investigations into war crimes and atrocities. +
+What we’re really fighting about when we fight about Barbie. +
++Like the Barbies in the movie Barbie, the film Barbie seemed capable of anything. From critical praise, to pop culture reverence, to box office domination, to culture war lightning rod, to doll sales, Barbie has checked every box. +
++But it’s the few things Barbie won’t achieve that have caused a massive uproar: namely, Best Actress and Best Directing Academy Award nominations for Margot Robbie and Greta Gerwig, respectively. +
++Their snubs have snowballed into an avalanche of proclamations that these exclusions show that the world we live in is brimming with misogyny and sexism. No matter that Gerwig and Robbie were recognized for screenwriting and producing, with the film nominated for a total of eight Oscars, including Best Picture. To some, it was even worse that Robbie’s co-star Ryan Gosling was nominated for Best Supporting Actor for playing Barbie’s patriarchy-loving non-boyfriend, Ken. +
++Columns upon columns were written, each one more enflamed than its predecessor. Gosling released a statement expressing disappointment about the snubs. Even former Secretary of State Hillary Clinton chimed in, offering consolation and condolences to Gerwig and Robbie. “While it can sting to win the box office but not take home the gold, your millions of fans love you,” she wrote, ending her message with a “#HillaryBarbie” hashtag. +
++A lot of people saw Barbie. A lot of people were moved by Barbie. A lot of people are now mad that Academy voters who saw Barbie were perhaps not moved in the same way they were. +
++Through the lens of Robbie’s snub, Gosling’s nod can feel a little salty. Coupled with Gerwig’s absence in the directing category, it makes the movie’s message — that the hard work of women goes unnoticed and unappreciated — seem like prophecy. +
++But the acute ferociousness, not to mention single-mindedness, of the Oscar nominations backlash seems to conflate the ideas of “Barbie” and “woman” in weird ways. Specifically, that rewarding or not rewarding Barbie with an Oscar is some kind of feminist barometer. Even more complicated is this entire conversation in the face of the Academy of Motion Pictures Sciences’ history of bias and startling lack of diversity. If, as fans point out, the Academy is a sexist organization, then why does Barbie need its awards? Would it somehow stop being sexist if Robbie and Gerwig got their nominations? +
++That these omissions have sparked such a vocal and strong reaction speaks to what Barbie stands for, its cultural impact, and how it has changed how we understand women’s stories. The things we talk about when we talk about Barbie are bigger than the movie itself. +
++The inescapable Barbie discourse is a testament to how the movie made its feminist message accessible. It begins as a riff on creationism: The Barbies live in Barbie Land, a place where female Barbies are capable of anything and everything — from President Barbie (Issa Rae) to Nobel Prize Barbie (Emma Mackey) to Doctor Barbie (Hari Nef) to Stereotypical Barbie (Robbie). The Kens, who are all named Ken, are just another Barbie accessory. +
+ ++Barbie’s savvy marketing department leaned into this concept of Barbie-feminist identification even before the movie was released, encouraging people on social media to post what kind of Barbie they would be with a selfie generator. Last month I visited my 3-year-old niece, and she had at least three new dolls — Doctor Barbie, President Barbie, and Pink Power Jumpsuit/Dismantle the Patriarchy Barbie. She wants to be just like the Barbies. +
++In the film, when Barbie and Ken venture to the real world, Ken finds out that men like him are in positions of power (doctor, president, cowboy) and are boosted by the patriarchy, a system he barely understands — and, crucially, doesn’t need to understand. Ken brings back symbols (horses and beer) and ideologies (subservient women) of the patriarchy to Barbie Land and brainwashes the trusting Barbies and eager Kens. He’s finally stopped by regular human woman Gloria (Academy Award nominee America Ferrera) who explains via monologue the hardships women are held to in the real world. Gloria restores order in Barbie Land, allowing Barbies to reclaim their power. Still, Stereotypical Barbie makes the choice to move to the real world, even with all its imperfections. +
++Using allegory and a hard-hitting speech, Barbie gives the audience a framework and language to point out the double standards that women endure, often without complaint. Barbie is cat-called on the street, and the Mattel overlords want to shove her into a box. Gloria is ignored in her job at Mattel, even though she has amazing ideas, and navigates the rejections of her teenage daughter seemingly alone, while her anodyne husband plays Duolingo. It raises the question of why society allows women to hurt like this, big and small. Why can’t things be better? +
++Inadvertently making the movie’s point — and reflexively making the movie an even bigger phenomenon — right-wing pundits and personalities dragged the film. Some hated its message about how men are treated in the real world, labeled the movie woke, and predicted, because of its said wokeness, Barbie’s box office demise. They called Barbie man-hating feminist propaganda. A few even tried to burn their Barbie dolls and boycott the movie. With all this commotion, Barbie and its box office success became politicized. Mattel and Warner Bros. likely didn’t envision the movie becoming the bane of some conservative firebrands’ existence, but largely due to the backlash, Barbie became even more of a touchstone and shorthand for feminism and equality. +
++The movie’s feminist message, combined with its huge marketing push, the corresponding Mattel merch, billion-dollar box office, and status as a culture war flashpoint made Barbie a pop culture phenomenon. Even before the Oscar nominations, Barbie was a national conversation. +
++On Tuesday, January 23, Oscar nominations rolled in. Gosling and Ferrera snagged theirs early, as supporting actors and actresses are the first categories in the announcement. But soon it became clear that Robbie didn’t make the cut for Best Actress or Gerwig for Best Directing. Barbie did get a nomination for Best Picture, the biggest prize of the show, as well as Best Adapted Screenplay, Best Production Design, Best Costume Design, and two Best Original Song nominations for Gosling’s “I’m Just Ken” and Billie Eilish’s “What Was I Made For?” +
++Usually, Oscar awards snubs and surprises are a fairly insular concern, something only people who are extremely enthusiastic about movies care about. Without Googling, it might be difficult for the average person to name more than one big omission from last year’s group of contenders. But it was different for Robbie and Gerwig’s exclusions, as their Oscar slights went mainstream. +
+ ++A common refrain: Ryan Gosling getting an Oscar nomination and Margot Robbie getting none proves the movie’s point. Similarly: If Gosling and Ferrera deserved accolades, so did Robbie and Gerwig. Also: Ryan Gosling got a nomination for Ken but Margot Robbie didn’t get one for playing Barbie in Barbie. And: The Academy is exactly what the movie was about. The Academy Awards ignoring Robbie and Gerwig was actually the sexism, misogyny, and patriarchy that’s explicitly addressed in the movie! +
++Outcry spiraled, growing and growing. Taylor Swift’s song about sexism, “The Man,” was invoked. A column appeared in the Los Angeles Times where Mary McNamara wrote: “If only Barbie had done a little time as a sex worker. Or barely survived becoming the next victim in a mass murder plot,” referring on the latter count to Lily Gladstone’s role as an Indigenous Osage woman witnessing the murders of her family and friends in Killers of the Flower Moon. Now, the backlash to the backlash has awoken some predictably cantankerous “Barbie is actually bad” takes. Truly no one has time for that. +
++To the movie’s most ardent and earnest fans, the misogyny and patriarchy Barbie depicted was, in real time, taking the form of the Academy of Motion Pictures and Sciences. +
++Criticisms about the movies the Academy has rewarded and the voting body’s biases aren’t necessarily wrong. Female directors and people of color across categories win so rarely that it becomes a milestone when they do (e.g., Halle Berry being the lone Black actress to win Best Actress, for 2001’s Monster’s Ball). In recent years, the organization itself has talked about its lack of diversity and tried to, via new members and new eligibility rules, address those issues. It’s a continual work in progress. +
++But the thing is, most of these arguments seem to imply that Robbie and Gerwig’s missed nominations — in acting and directing — are the only feminist wins that count. They were not the only women thought to be frontrunners who were ignored this year, and many found themselves asking where this energy was for Celine Song and Greta Lee, the director and star of Past Lives, or Ava Duvernay and Aunjanue Ellis, director and star of Origin. Unfortunately, centering particular white women and largely forgetting women of color or the intersectionality of feminism is a pattern that arises in these fights for recognition. +
++These arguments also serve to undermine the nominees who were recognized. Best Picture nominee Anatomy of a Fall, written and directed by Best Directing nominee Justine Triet, examined society’s ideas about gender and who we see as victims. Killers of the Flower Moon told the story of Mollie Burkhart and the atrocities committed against her people. Gladstone, who played Burkhart, is the first Native American to be nominated for Best Actress at the Oscars. +
++It’s also worth noting that while Gosling’s acting nomination is being presented as a slight to Robbie, Robbie’s competition is the rest of the Best Actress field — not Gosling. Five other women, including Gladstone, were nominated instead of Robbie. That field also doesn’t include critically lauded performances from Lee, Ellis, and Natalie Portman, who Robbie would also had to have edged out to be recognized. It seems notable, too, that Ferrera’s nomination isn’t being lauded. +
++Framing praise for Gosling’s performance in the movie as some kind of negative is strange in that his character is an integral part of this feminist movie. It’s like saying Heath Ledger’s performance as the Joker in The Dark Knight shouldn’t be recognized because that character represents the evil that Batman is fighting against. Gosling’s performance is a credit to the character and decisions that the director, screenwriters, and producers made. +
+ ++Robbie was nominated as a producer by way of Barbie’s Best Picture nomination. Luckychap, the production company Robbie co-founded in 2014, touts itself as helping create female-focused television and movies like I, Tonya, Promising Young Woman, and Barbie. Robbie winning for producing Barbie would be huge for a mission she seems to take pride in. +
++In the grand scheme of things, I’m not quite sure if a nomination for Robbie in acting or Gerwig in directing would be considered a capital-W win for feminism. As critics of the backlash have already pointed out, there are bigger issues facing women. Individual nominations would not single-handedly solve the problem of the Academy’s biases and failure to recognize talent. Barbie could win all the Oscars and those problems would still exist. +
++
AUS vs WI pink ball Test | Steve Smith guides Australia to healthy position at stumps - Australia’s hopes of taking the win, however, may be hampered by predicted heavy rain for the next two days.
Australian Open 2024 | Aryna Sabalenka crushes Zheng Qinwen; first woman to defend singles title in a decade - The last time the tournament witnessed a successful women’s title defence was in 2013, when fellow Belarusian Victoria Azarenka achieved the feat.
Indian men’s hockey team beats SA 3-0 on home soil - Captain Harmanpreet Singh (2nd minute), Abhishek (13th), and Sumit (30th) scored for the winners on Jan. 26 night.
Ind vs Eng 1st Test | Ollie Pope’s ton helps England to 126-run lead on Day 3 - In reply to England’s 246, India were all out for 436 in the morning session
FA Cup | Ake’s late goal sends Man City into 5th round, Chelsea held - After the game, Manchester City coach Pep Guardiola said he would miss Liverpool manager Jurgen Klopp, who announced he would leave the club, but said that he could now sleep better when City plays Liverpool
Kharge writes to Mamata seeking safety of Rahul Gandhi’s Bharat Jodo Nyay Yatra in West Bengal -
Telangana CM announces caste census -
Railways land-for-job case | Delhi court summons former Bihar CM Rabri Devi, daughter Misa Bharti -
Lok Sabha polls: BJP appoints election in-charges, co-in-charges for 23 States, Union Territories - BJP national secretary Arvind Menon has been appointed as election in-charge for Tamil Nadu.
Gyanvapi mosque committee should handover structure to Hindus: VHP chief - The VHP said that it believes that this righteous action would be an important step towards creating amicable relations between the two communities
Why Europe’s farmers are taking their anger to the streets - Europe is swept by a wave of protests by farmers, who blame EU policies for their hardship.
US approves F-16 fighter jet sale to Turkey worth $23bn - The $23bn sale comes after Turkey ratified Sweden’s accession to Nato this week.
Czech Republic MPs vote to tighten gun laws - But it’s unclear whether the proposed new rules would have stopped the Prague shooter.
Evan Gershkovich: Russia again extends detention of US journalist - The Moscow court’s ruling means Evan Gershkovich will spend over one year behind bars as he awaits trial.
Identical twins separated and sold at birth reunited by TikTok - Thousands of people in Georgia have found out they were stolen from their parents at birth and sold.
In major gaffe, hacked Microsoft test account was assigned admin privileges - How does a legacy test account grant access to read every Office 365 account? - link
Measles is “growing global threat,” CDC tells doctors in alert message - Since December, there have been 23 measles cases in the US, including two outbreaks. - link
NSA finally admits to spying on Americans by purchasing sensitive data - Violating Americans’ privacy “not just unethical but illegal,” senator says. - link
Dungeons & Dragons turns 50 this year, and there’s a lot planned for it - It started with “a new line of miniatures rules” and became a global phenomenon. - link
Tens of thousands of pregnancies from rape occurring in abortion-ban states - States with bans logged 10 or fewer legal abortions per month, despite rape exceptions. - link
A Scottish cow farmer sees an Englishman crossing his field -
++The Englishman stoops down to a little stream to take a drink. The Scotsman yells, “Ye cannae drink tha! It’s fool of coo piss an’ shite!” +
++To which the Englishman says, “I can’t understand you. Speak English properly.” +
++The Scotsman responds, “I said use both hands!” +
+ submitted by /u/testudoaubreii1
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Which rock group has four men, including one named George and another who was shot to death? -
++Mount Rushmore +
+ submitted by /u/wimpykidfan37
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70 year old man goes out and buys himself a new sports car -
++As he’s cruising down the highway at 75 mph, he sees a cop with their lights on start to give chase. Not wanting to get a speeding ticket with his new car the old man decides to floor it and shake the cop. So he guns it 85,95, 120 MPH flying down the highway swerving in and out of traffic. This goes on for a good hour with the cop keeping pace. Finally the old man has a change of heart and pulls over to the shoulder. The officer gets out walks up to the old man and says. “Look I have been chasing you for over an hour and I was supposed to get off shift 30 minutes ago and REALLY do not want to fil out all the paperwork that you are going to cause me to do. So if you can give me a damn good reason why I shouldn’t haul you off to jail, I’ll let you go with a warning.” The old man sits thinks for a minute and goes “10 years ago my wife left me for a cop, I thought you had tracked me and were trying to return her.” The cop replies “Sir, have a good day and remember to wear your seatbelt.” +
+ submitted by /u/cikanman
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Married couple -
++It is 12.02am and a married couple have just finished having sex. +
++The wife thinks for a moment and then hits her husband. +
++“Ouch!” he says, “why did you do that?” +
++“That’s for being a lousy lover!” she says. +
++The guy thinks for a while and then hits her back. +
++“Ouch!” she says, “why did you do that?” +
++“That’s for knowing the difference!” he says. +
+ submitted by /u/jimph
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Airman Jones was assigned to the induction center, where he advised new recruits about their GI insurance. It wasn’t long before Captain Smith noticed that Airman Jones was having a staggeringly high success-rate, selling insurance to nearly 100% of the recruits he advised. -
++Rather than ask about this, the Captain stood in the back of the room and listened to Jones’ sales pitch. Jones explained the basics of the GI Insurance to the new recruits, and then said: “If you have GI Insurance and go into battle and are killed, the government has to pay $200,000 to your beneficiaries. If you don’t have GI insurance, and you go into battle and get killed, the government only has to pay a maximum of $6000. Now,” he concluded, “which group do you think they are going to send into battle first?” +
+ submitted by /u/YZXFILE
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