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<title>Covid-19 Sentry</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<h1 data-aos="fade-down" id="covid-19-sentry">Covid-19 Sentry</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-preprints">From Preprints</a></li>
<li><a href="#from-clinical-trials">From Clinical Trials</a></li>
<li><a href="#from-pubmed">From PubMed</a></li>
<li><a href="#from-patent-search">From Patent Search</a></li>
</ul>
<h1 data-aos="fade-right" id="from-preprints">From Preprints</h1>
<ul>
<li><strong>Covid Fast Fax: A system for real-time triage of Covid-19 case report faxes</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The scale and speed of the COVID-19 pandemic has strained many parts of the national healthcare infrastructure, including communicable disease monitoring and prevention. Many local health departments now receive hundreds or thousands of COVID-19 case reports a day. Many arrive via faxed handwritten forms, often intermingled with other faxes sent to a general fax line, making it difficult to rapidly identify the highest priority cases for outreach and monitoring. We present an AI-based system capable of real-time identification and triage of handwritten faxed COVID-19 forms. The system relies on two models: one model to identify which received pages correspond to case report forms, and a second model to extract information from the set of identified case reports. We evaluated the system on a set of 1,122 faxes received by a local health department over a two-week period. For the 88% of faxes of sufficient quality, the system detects COVID-19 reports with high precision, 0.98, and high recall, 0.91. Among all received COVID-19 faxes, the system identifies high priority cases with a specificity of 0.87, a precision of 0.46 and recall of 0.83. Our system can be adapted to new forms, after a brief training period. Covid Fast Fax can support local health departments in their efforts to control the spread of COVID-19 and limit its impact on the community. The tool is freely available.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248256v1" target="_blank">Covid Fast Fax: A system for real-time triage of Covid-19 case report faxes</a>
</div></li>
<li><strong>Accelerated intermittent theta burst as a substitute for patients needing electroconvulsive therapy during the COVID-19 pandemic: study protocol for an open-label clinical trial</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Treatment resistant depression (TRD) is one of the leading causes of disability in Canada and is associated with significant societal costs. Repetitive transcranial magnetic stimulation (rTMS) is an approved, safe, and well-tolerated intervention for TRD. In the setting of the COVID-19 pandemic, reducing the number of visits to the clinic is a potential approach to significantly minimize exposure and transmission risks to patients. This can be accomplished by administering multiple treatment sessions in a single day, using an rTMS protocol known as accelerated intermittent theta burst stimulation (aiTBS). The objective of this novel study is to assess the feasibility, acceptance and clinical outcomes of a practical high-dose aiTBS protocol, including tapering treatments and symptom-based relapse prevention treatments, in patients with unipolar depression previously responsive to electroconvulsive therapy (ECT) or patients warranting ECT due to symptom severity. Methods: All patients with unipolar depression referred to the brain stimulation service at the Centre for Addiction and Mental Health (CAMH) who warrant ECT will be offered screening to assess for eligibility to enroll in this trial. This open label, single group trial consists of 3 phases. In the acute treatment phase, treatment will occur 8 times daily for 5 days a week, until symptom remission is achieved or a maximum of 10 days of treatment. In the tapering phase, treatments will be reduced to 2 treatment days per week for 2 weeks, followed by 1 treatment day per week for 2 weeks. Patients will then enter the symptom-based relapse prevention phase including virtual check-ins and a treatment schedule based on symptom level. Remission, response and change in scores on several clinical measures from baseline to the end of the acute, tapering and relapse prevention phases represent the clinical outcomes of interest. Discussion: Findings from this novel clinical trial may provide support for the use of aiTBS, including tapering treatments and symptom-based relapse prevention treatments, as a safe and effective alternative intervention for patients needing ECT during the COVID-19 pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248260v1" target="_blank">Accelerated intermittent theta burst as a substitute for patients needing electroconvulsive therapy during the COVID-19 pandemic: study protocol for an open-label clinical trial</a>
</div></li>
<li><strong>Exploring patient experiences of video consultations during Covid-19 in an outpatient care setting using routine feedback data from 955 contacts</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Abstract Objectives: Video consultations (VCs) have been rapidly implemented in response to Covid-19. However, limited research has explored patient experiences of VCs in this context. This research therefore explored patient experiences of VCs during their early stages of implementation in response to Covid-19. Design: Secondary data analysis of routine patient survey responses using descriptive statistics and inductive thematic analysis. Setting and participants: 955 (22.6%) survey responses following a VC using Attend Anywhere in a rural, aging and outpatient care setting between June and July 2020. Results: Most (93.2%) respondents reported having good (n=210, 22.0%), or very good (n=680, 71.2%) experiences with VCs. Most respondents accessed their VC alone (n=806, 84.4%), except for those aged 71+ (n=23/58, 39.7%). Most participants reported feeling listened to and understood (n=904, 94.7%), felt their needs had been met (n=860, 90.1%) and were able to communicate everything they wanted (n=848, 88.8%). Satisfaction with communication was very strongly associated with satisfaction with the technical performance of the VC (p&lt;0.001). Free text responses had three key themes: i) barriers to VC use including technological difficulties, quality of patient information and accessibility or suitability concerns; ii) potential benefits including reduced stress and anxiety, enhanced accessibility, cost and time savings; and iii) patient suggested improvements including trial calls, turning music off, facilitating photo uploads, expanding written character limit and supporting other internet browsers. Most (92.1%) participants were likely to choose a VC again in the future. Conclusions: The vast majority of respondents reported positive experiences of VCs. Identified benefits of enhanced accessibility, affordability, time, monetary and environmental savings are particularly interesting for future service delivery. Further research is needed, using rapid co-design techniques, to improve feedback methods, patient information and experience to support sustainability and to address accessibility and experience of patients excluded from this work, through lack of VC access.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248235v1" target="_blank">Exploring patient experiences of video consultations during Covid-19 in an outpatient care setting using routine feedback data from 955 contacts</a>
</div></li>
<li><strong>Creating an e-cohort of individuals with lived experience of homelessness and subsequent mortality in Wales, UK.</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Homelessness is an extreme form of social exclusion, with homeless people experiencing considerable social and health inequities. Estimates of morbidity and mortality amongst homeless populations is limited due to the lack of recording of housing status across health datasets. The aim of this study is to: (1) identify a homelessness e-cohort by linking routine health data, and (2) explore whether a period of reported past homelessness, places this population at greater risk of morbidity and mortality. Methods: Homelessness identified through linkage across primary, secondary care, and substance misuse datasets in the Secure Anonymised Information Linkage (SAIL) Databank. Mortality was examined through linkage to the Office for National Statistics mortality data. Results: E-cohort of 15,472 individuals with lived experience of homelessness identified. Of those, 21 individuals died between February and July 2020 from COVID-19. Those with lived experience of homelessness had increased mortality from many causes including COVID-19, i.e. accidents, liver diseases and suicides. Conclusion: Linking multiple routine datasets provides a more comprehensive dataset of a marginalised population. Application of the cohort demonstrated that individuals with lived experience of homelessness have increased mortality from COVID-19 and other causes. The underlying reasons, health needs, and causes of death warrant further exploration.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248252v1" target="_blank">Creating an e-cohort of individuals with lived experience of homelessness and subsequent mortality in Wales, UK.</a>
</div></li>
<li><strong>Influence of clinical characteristics and anti-cancer therapy on outcomes from SARS-CoV-2 infection: a systematic review and meta-analysis of 5,678 cancer patients</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background The COVID-19 pandemic started a healthcare crisis and heavily impacted cancer services. Methods Data from cohort studies of COVID-19 cancer patients published up until October 23rd 2020 from PubMed, PubMed Central, medRxiv and Google Scholar were reviewed. Meta-analyses using the random effects model was performed to assess the risk of death in cancer patients with COVID-19. Results Our meta-analyses including up to 5,678 patients from 13 studies showed that the following were all statistically significant risk factors for death following SARS-CoV-2 infection in cancer patients: age of 65 and above, presence of co-morbidities, cardiovascular disease, chronic lung disease, diabetes and hypertension. There was no evidence that patients who had received cancer treatment within 60 days of their COVID-19 diagnosis were at a higher risk of death, including patients who had recent chemotherapy. Conclusions Cancer patients are susceptible to severe COVID-19, especially older patients and patients with co-morbidities who will require close monitoring. Our findings support the continued administration of anti-cancer therapy during the pandemic. The analysis of chemotherapy was powered at 70% to detect an effect size of 1.2 but all other anti-cancer treatments had lower power. Further studies are required to better estimate their impact on the outcome of cancer patients.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248195v1" target="_blank">Influence of clinical characteristics and anti-cancer therapy on outcomes from SARS-CoV-2 infection: a systematic review and meta-analysis of 5,678 cancer patients</a>
</div></li>
<li><strong>Impact of COVID-19 related unemployment on increased cardiovascular disease in a high-income country: Modeling health loss, cost and equity</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Background: Cardiovascular disease (CVD) is a leading cause of health loss and health sector economic burdens in high-income countries. Unemployment is associated with increased risk of CVD, and so there is concern that the economic downturn associated with the COVID-19 pandemic will increase the CVD burden. Aims: This modeling study aimed to quantify health loss, health cost burden and health inequities among people with CVD due to additional unemployment caused by COVID-19 pandemic-related economic disruption in one high-income country: New Zealand (NZ). Methods: We adapted an established and validated multi-state life-table model for CVD in the national NZ population. We modeled indirect effects (ie, higher CVD incidence due to high unemployment rates) for various scenarios of pandemic-related unemployment projections. Results: We estimated the CVD-related heath loss in NZ to range from 23,300 to 36,900 HALYs (health-adjusted life years) for the different unemployment scenarios. Health inequities for Māori (Indigenous population) were 3.7 times greater compared to non-Māori (49.9 vs 13.5 HALYs lost per 1000 people). Conclusions and policy implications: Unemployment due to the COVID-19 pandemic is likely to cause significant health loss and health inequities from CVD in this high-income country. Prevention measures should be considered by governments to reduce this risk, including job creation programs and measures directed towards CVD prevention.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248284v1" target="_blank">Impact of COVID-19 related unemployment on increased cardiovascular disease in a high-income country: Modeling health loss, cost and equity</a>
</div></li>
<li><strong>Quantifying the importance and location of SARS-CoV-2 transmission events in large metropolitan areas</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Detailed characterizations of SARS-CoV-2 transmission risk across different social settings can inform the design of targeted and less disruptive non-pharmaceutical interventions (NPI), yet these data have been lacking. Here we integrate real-time, anonymous and privacy-enhanced geolocalized mobility data with census and demographic data in the New York City and Seattle metropolitan areas to build a detailed agent-based model of SARS-CoV-2 transmission. The aim is to estimate where, when, and how many transmission events happened in those urban areas during the first wave of the pandemic. We estimate that most infections (80%) are produced by a small number of people (27%), and that about 10% of events can be considered super-spreading events (SSEs), i.e. generating more than eight secondary infections. Although mass gatherings present an important risk for future SSEs, we find that the bulk of transmission in the first wave occurred in smaller events at settings like workplaces, grocery stores, or food venues. We also observe that places where the majority of transmission and SSEs happened changed during the pandemic and are different across cities, a signal of the large underlying behavioral component underneath them. Our results demonstrate that constant real-time tracking of transmission events is needed to create, evaluate, and refine more effective and localized measures to contain the pandemic.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248273v1" target="_blank">Quantifying the importance and location of SARS-CoV-2 transmission events in large metropolitan areas</a>
</div></li>
<li><strong>Exposure to Renin-Angiotensin System Inhibitors Is Associated with Reduced Mortality of Older Hypertensive Covid-19 Patients</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
From a cohort of 1352 consecutive patients admitted with coronavirus disease (Covid-19) to Papa Giovanni XXIII Hospital in Bergamo, Italy, between February and April 2020, we selected and studied 688 patients with arterial hypertension (254 deaths) to assess whether use of renin-angiotensin system inhibitors (RASIs) prior to hospital admission affects mortality from Covid-19. Prior use of RASIs was associated with a lower mortality in the over-68 group of patients, whereas no evidence of a similar effect (whether protective or adverse) was found in the younger group. There was positive relative excess due to a statistically significant (P=0.001) interaction between prior RASI exposure and an age greater than 68 years, corresponding to a positive relative excess risk. Next we used the subgroup of 411 hypertensive patients older than 68 yrs to separately assess the effects of prior use of two RASI drug subclasses, angiotensin-converting enzyme inhibitors (ACEIs) and angiogiotensin receptor blockers (ARBs), by comparing these two exposures with no exposure to RASIs. We found both prior use of ACEIs and prior use of ARBs to be associated with a lower Covid-19 mortality, after adjusting for 32 medical history variables via propensity score matching. (OR-ACEI=0.57, 95%CI 0.36 to 0.91, P=0.018) (OR-ARB=0.49, 95%CI 0.29 to 0.82, P=0.006). Keywords: Covid-19, SARS-CoV-2, renin-angiotensin-system inhibitors, angiotensin-converting enzyme inhibitors, angiogiotensin receptor blockers, ACE, ARB, Sartan, elderly, hypertension, propensity score, matching, effect modification, observational study, clinical epidemiology.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20247999v1" target="_blank">Exposure to Renin-Angiotensin System Inhibitors Is Associated with Reduced Mortality of Older Hypertensive Covid-19 Patients</a>
</div></li>
<li><strong>cAMP prevents antibody-mediated thrombus formation in COVID-19</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Thromboembolic events are frequently reported in patients infected with the SARS-CoV-2 virus. However, the exact mechanisms of thromboembolic events remain elusive. In this work, we show that immunoglobulin G (IgG) subclass in patients with COVID-19 trigger the formation of procoagulant PLTs in a Fc-gamma-RIIA dependent pathway leading to increased thrombus formation in vitro. Most importantly, these events were significantly inhibited via Fc-gamma-RIIA blockade as well as by the elevation of PLTs intracellular cyclic-adenosine-monophosphate (cAMP) levels by the clinical used agent Iloprost. The novel findings of Fc-gamma-RIIA mediated prothrombotic conditions in terms of procoagulant PLTs leading to higher thrombus formation as well as the successful inhibition of these events via Iloprost could be promising for the future treatment of the complex coagulopathy observed in COVID-19 disease.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20247775v1" target="_blank">cAMP prevents antibody-mediated thrombus formation in COVID-19</a>
</div></li>
<li><strong>QFEA - A Method for Assessing the Filtration Efficiency of Face Mask Materials for Early Design Prototypes and Home Mask Makers</strong> -
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The COVID-19 pandemic has led to a surge in the design and production of fabric face coverings. There are few published methods which enable mask designers, makers and purchasers to assess the relative filtration ability of mask making materials. Those methods which do exist are prohibitively expensive and difficult to conduct. As a result, mask makers, non-profits, and small-scale designers face difficult decisions when designing face coverings for personal and commercial use. In this paper, we propose a novel method, the Qualitative Filtration Efficiency Assessment (QFEA), for easily and inexpensively comparing the filtration efficiency of common materials. This method provides a highly affordable and readily available way to assess potential mask materials.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.14.20221937v1" target="_blank">QFEA - A Method for Assessing the Filtration Efficiency of Face Mask Materials for Early Design Prototypes and Home Mask Makers</a>
</div></li>
<li><strong>Extraction-free protocol combining Proteinase K and heat inactivation for detection of SARS-CoV-2 by RT-qPCR</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Real-time reverse transcription PCR (RT-qPCR) is the gold-standard technique for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection in nasopharyngeal swabs specimens. The analysis by RT-qPCR usually requires a previous extraction step to obtain the purified viral RNA. Unfortunately, RNA extraction constitutes a bottleneck for early detection in many countries since it is expensive, time-consuming and depends on the availability of commercial kits. Here, we describe an extraction-free protocol for SARS-CoV-2 detection by RT-qPCR from nasopharyngeal swab clinical samples in saline solution. The method includes a treatment with proteinase K followed by heat inactivation (PK+HID method). We demonstrate that PK+HID improves the RT-qPCR performance in comparison to the heat-inactivation procedure. Moreover, we show that this extraction-free protocol can be combined with a variety of multiplexing RT-qPCR kits. The method combined with a multiplexing detection kit targeting N and ORF1ab viral genes showed a sensitivity of 0.99 and a specificity of 0.99 from the analysis of 106 positive and 106 negative clinical samples. In conclusion, PK+HID is a robust, fast and inexpensive procedure for extraction-free RT-qPCR determinations of SARS-CoV-2.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.16.20248350v1" target="_blank">Extraction-free protocol combining Proteinase K and heat inactivation for detection of SARS-CoV-2 by RT-qPCR</a>
</div></li>
<li><strong>Determinants of SARS-CoV-2 transmission to guide vaccination strategy in a city</strong> -
<div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Transmission chains within cities provide an important contribution to case burden and economic impact during the ongoing COVID-19 pandemic, and should be a major focus for preventive measures to achieve containment. Here, at very high spatio-temporal resolution, we analysed determinants of SARS-CoV-2 transmission in a medium-sized European city. We combined detailed epidemiological, mobility, and socioeconomic data-sets with whole genome sequencing during the first SARS-CoV-2 wave. Both phylogenetic clustering and compartmental modelling analysis were performed based on the dominating viral variant (B.1-C15324T; 60% of all cases). Here we show that transmissions on the city population level are driven by the socioeconomically weaker and highly mobile groups. Simulated vaccination scenarios showed that vaccination of a third of the population at 90% efficacy prioritising the latter groups would induce a stronger preventive effect compared to vaccinating exclusively senior population groups first. Our analysis accounts for both social interaction and mobility on the basis of molecularly related cases, thereby providing high confidence estimates of the underlying epidemic dynamics that may readily be translatable to other municipal areas.
</p>
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.medrxiv.org/content/10.1101/2020.12.15.20248130v1" target="_blank">Determinants of SARS-CoV-2 transmission to guide vaccination strategy in a city</a>
</div></li>
<li><strong>Refuting Spurious COVID-19 Treatment Claims Reduces Demand and Misinformation Sharing</strong> -
<div>
The COVID-19 pandemic has seen a surge of health misinformation, which has had serious consequences including direct harm and opportunity costs. We investigated (N = 678) the impact of such misinformation on hypothetical demand (i.e., willingness-to-pay) for an unproven treatment, and propensity to promote (i.e., like or share) misinformation online. This is a novel approach, as previous research has used mainly questionnaire-based measures of reasoning. We also tested two interventions to counteract the misinformation, contrasting a tentative refutation based on materials used by health authorities with an enhanced refutation based on best-practice recommendations. We found prior exposure to misinformation increased misinformation promotion (by 18%). Both tentative and enhanced refutations reduced demand (by 18% and 25%, respectively) as well as misinformation promotion (by 29% and 55%). The fact that enhanced refutations were more effective at curbing promotion of misinformation highlights the need for debunking interventions to follow current best-practice guidelines.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://psyarxiv.com/q3mkd/" target="_blank">Refuting Spurious COVID-19 Treatment Claims Reduces Demand and Misinformation Sharing</a>
</div></li>
<li><strong>Explaining Support for COVID-19 Cell Phone Contact Tracing</strong> -
<div>
COVID-19 contact tracing applications have been deployed at a fast pace around the world and may be a key policy instrument to contain future waves in Canada. This study aims to explain public opinion toward cell phone contact tracing using a survey experiment conducted with a representative sample of Canadian respondents. We build upon an established theory in evolutionary psychology—disease avoidance—to predict how media coverage of the pandemic affects public support for containment measures. We report three key findings. First, exposure to a news item that shows people ignoring social distancing rules causes an increase in support for cell phone contact tracing. Second, pre-treatment covariates such as anxiety and a belief that other people are not following the rules rank among the strongest predictors of support for COVID-19 apps. And third, while a majority of respondents approve the reliance on cell phone contact tracing, many of them hold ambivalent thoughts about the technology. Our analysis of answers to an open-ended question on the topic suggests that concerns for rights and freedoms remain a salient preoccupation.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://osf.io/preprints/socarxiv/8wcgz/" target="_blank">Explaining Support for COVID-19 Cell Phone Contact Tracing</a>
</div></li>
<li><strong>One Year of SARS-CoV-2: How Much Has the Virus Changed?</strong> -
<div>
SARS-CoV-2 coronavirus has caused a world-wide crisis with profound effects on both healthcare and the economy. In order to combat the COVID-19 pandemic, research groups have shared viral genome sequence data through the GISAID initiative. We collected and computationally profiled ~223,000 full SARS-CoV-2 proteome sequences from GISAID over one year for emergent nonsynonymous mutations. Our analysis shows that SARS-CoV-2 proteins are mutating at substantially different rates, with most viral proteins exhibiting little mutational variability. As anticipated, our calculations capture previously reported mutations occurred in the first period of the pandemic, such as D614G (Spike), P323L (NSP12), and R203K/G204R (Nucleocapsid), but also identify recent mutations like A222V and L18F (Spike) and A220V (Nucleocapsid). Our comprehensive temporal and geographical analyses show two periods with different mutations in the SARS-CoV-2 proteome: December 2019 to June 2020 and July to November 2020. Some mutation rates differ also by geography; the main mutations in the second period occurred in Europe. Furthermore, our structure-based molecular analysis provides an exhaustive assessment of mutations in the context of 3D protein structure. Emerging sequence-to-structure data is beginning to reveal the site-specific mutational tolerance of SARS-CoV2 proteins as the virus continues to spread around the globe.
</div>
<div class="article-link article-html-link">
🖺 Full Text HTML: <a href="https://www.biorxiv.org/content/10.1101/2020.12.16.423071v1" target="_blank">One Year of SARS-CoV-2: How Much Has the Virus Changed?</a>
</div></li>
</ul>
<h1 data-aos="fade-right" id="from-clinical-trials">From Clinical Trials</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Phase II / III Study of COVID-19 DNA Vaccine (AG0302-COVID19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Group A (AG0302-COVID19);   Biological: Group A (Placebo);   Biological: Group B (AG0302-COVID19);   Biological: Group B (Placebo)<br/><b>Sponsors</b>:   AnGes, Inc.;   Japan Agency for Medical Research and Development<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Changes in Viral Load in COVID-19 After Probiotics</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Dietary Supplement: Dietary supplementation in patients with covid disease admitted to hospital<br/><b>Sponsors</b>:   Hospital de Sagunto;   Biopolis S.L.;   Laboratorios Heel España<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Efficacy and Safety of High-dose Vitamin C Combined With Chinese Medicine Against Coronavirus Pneumonia (COVID-19)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Alpha-interferon alpha, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste, fumigation/inhalation of vitamin C;   Drug: Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and 5% glucose;   Drug: Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and high-dose vitamin C treatment<br/><b>Sponsor</b>:   Xi'an International Medical Center Hospital<br/><b>Active, not recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (SARS-CoV-2 Infected)</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: AZVUDINE;   Drug: AZVUDINE placebo<br/><b>Sponsors</b>:   HRH Holdngs Limited;   GALZU INSTITUTE OF RESEARCH, TEACHING, SCIENCE AND APPLIED TECHNOLOGY, Brazil;   SANTA CASA DE MISERICORDIA DE CAMPOS HOSPITAL (SCMCH), Brazil;   UNIVERSIDADE ESTADUAL DO NORTE FLUMINENSE (UENF), Brazil<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mushroom-based Product for COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Drug: FoTv<br/><b>Sponsors</b>:   Gordon Saxe;   University of California, Los Angeles;   University of California, Irvine<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Study to Investigate the Treatment Effect of Colchicine in Patients With COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: Colchicine;   Drug: Standard COVID-19 care<br/><b>Sponsors</b>:   Ayub Teaching Hospital;   Universidad de Murcia<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Safety and Immunogenicity Study of AdCLD-CoV19: A COVID-19 Preventive Vaccine in Healthy Volunteers</strong> - <b>Condition</b>:   COVID-19<br/><b>Intervention</b>:   Biological: AdCLD-CoV19<br/><b>Sponsor</b>:   Cellid Co., Ltd.<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Controlled Phase 2/3 Study of Adjuvanted Recombinant SARS-CoV-2 Trimeric S-protein Vaccine (SCB-2019) for the Prevention of COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: AS03-adjuvanted SCB-2019 vaccine;   Biological: Placebo; 0.9% saline<br/><b>Sponsors</b>:   Clover Biopharmaceuticals AUS Pty Ltd;   The Coalition for Epidemic Preparedness Innovations;   International Vaccine Institute<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Study to Assess the Virologic Efficacy of REGN10933+REGN10987 Across Different Dose Regimens in Adult Outpatients With SARS-CoV-2 Infection</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Drug: REGN10933+REGN10987 combination therapy;   Drug: Placebo<br/><b>Sponsor</b>:   Regeneron Pharmaceuticals<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Efficacy, Safety and Immunogenicity Study of Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19</strong> - <b>Condition</b>:   COVID-19<br/><b>Interventions</b>:   Biological: Inactivated SARS-CoV-2 Vaccine (Vero cell);   Biological: Placebo<br/><b>Sponsor</b>:   Chinese Academy of Medical Sciences<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Sarilumab Treatment In cytoKinE Storm Caused by Infection With COVID-19</strong> - <b>Condition</b>:   COVID-19 Drug Treatment<br/><b>Intervention</b>:   Drug: Sarilumab<br/><b>Sponsors</b>:   Clinica Universidad de Navarra, Universidad de Navarra;   Sanofi;   Hospital Universitario Infanta Leonor<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluating Safety, Pharmacokinetics and Clinical Benefit of Silmitasertib (CX-4945) in Subjects With Moderate COVID-19</strong> - <b>Condition</b>:   Covid19<br/><b>Interventions</b>:   Drug: Silmitasertib;   Drug: SOC<br/><b>Sponsor</b>:   Chris Recknor, MD<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Evaluation of the Efficacy of High Doses of Methylprednisolone in SARS-CoV2 ( COVID-19) Pneumonia Patients</strong> - <b>Condition</b>:   Covid19<br/><b>Intervention</b>:   Drug: Methylprednisolone, Placebo<br/><b>Sponsor</b>:   Azienda Unità Sanitaria Locale Reggio Emilia<br/><b>Not yet recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Risk of Infection of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), COVID-19, in a Massive Musical Show With Transmission Prevention Measures</strong> - <b>Condition</b>:   COVID-19 (SARS-CoV-2)<br/><b>Intervention</b>:   Behavioral: Participate in a massive musical event<br/><b>Sponsors</b>:   Fundacio Lluita Contra la SIDA;   Dr. Bonaventura Clotet Sala;   Dr. Josep Mª LLibre Codina;   Dr. Boris Revollo Barriga;   Dra. Lidia Ruiz Tabuenca;   Dr. Ignacio Blanco Guillermo;   Dra. Andrea Alemany Ortiz;   Dr. Roger Paredes Deiros<br/><b>Recruiting</b></p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Use of BCG Vaccine as a Preventive Measure for COVID-19 in Health Care Workers</strong> - <b>Condition</b>:   COVID 19 Vaccine<br/><b>Intervention</b>:   Biological: BCG vaccine<br/><b>Sponsors</b>:   Universidade Federal do Rio de Janeiro;   Ministry of Science and Technology, Brazil<br/><b>Recruiting</b></p></li>
</ul>
<h1 data-aos="fade-right" id="from-pubmed">From PubMed</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>IFIT Proteins Are Involved in CXCL10 Expression in Human Glomerular Endothelial Cells Treated with a Toll-Like Receptor 3 Agonist</strong> - CONCLUSION: IFIT1/2/3 and CXCL10 were induced by poly IC via IFN-β in GECs. IFIT1/2/3 may increase the expression of CXCL10 which induces lymphocyte chemotaxis and may inhibit the replication of infected viruses. These molecules may play a role in GEC innate immune reactions in response to viruses.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2</strong> - Soluble forms of angiotensin-converting enzyme 2 (ACE2) have recently been shown to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We report on an improved soluble ACE2, termed a "microbody," in which the ACE2 ectodomain is fused to Fc domain 3 of the immunoglobulin (Ig) heavy chain. The protein is smaller than previously described ACE2-Ig Fc fusion proteins and contains an H345A mutation in the ACE2 catalytic active site that inactivates the enzyme without...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators</strong> - Viruses are obligate intracellular parasites that make use of the host metabolic machineries to meet their biosynthetic needs. Thus, identifying the host pathways essential for the virus replication may lead to potential targets for therapeutic intervention. The mechanisms and pathways explored by SARS-CoV-2 to support its replication within host cells are not fully known. Lipid droplets (LD) are organelles with major functions in lipid metabolism, energy homeostasis and intracellular transport,...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Elucidating the pivotal role of convalescent plasma therapy in critically ill COVID-19 patients: A review</strong> - World Health Organization (WHO) declared coronavirus disease (COVID-19) a pandemic in March 2020. Currently almost every country in the world has reported cases with moderate to high mortality rates. The European Union (EU), the United States of America (USA) and the United Kingdom (UK) are the severely affected countries. Nevertheless, the WHO is very much concern about countries with weak health systems. The clinical characteristics of COVID-19 varies extensively, ranging from asymptomatic...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2</strong> - A consensus virtual screening protocol has been applied to ca. 2000 approved drugs to seek inhibitors of the main protease (M^(pro)) of SARS-CoV-2, the virus responsible for COVID-19. 42 drugs emerged as top candidates, and after visual analyses of the predicted structures of their complexes with M^(pro), 17 were chosen for evaluation in a kinetic assay for M^(pro) inhibition. Remarkably 14 of the compounds at 100-μM concentration were found to reduce the enzymatic activity and 5 provided IC(50)...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2</strong> - COVID-19 pandemic has infected millions of people with mortality exceeding &gt;1 million. There is an urgent need to find therapeutic agents that can help clear the virus to prevent severe disease and death. Identifying effective and safer drugs can provide more options to treat COVID-19 infections either alone or in combination. Here, we performed a high throughput screening of approximately 1,700 US FDA-approved compounds to identify novel therapeutic agents that can effectively inhibit...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities</strong> - The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) requires urgent clinical interventions. Crucial clinical needs are: 1) prevention of infection and spread of the virus within lung epithelia and between people, 2) attenuation of excessive lung injury in Advanced Respiratory Distress Syndrome, which develops during the end stage of the disease, and 3) prevention of thrombosis associated with SARS-CoV-2 infection....</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Deciphering the Pharmacological Mechanisms of Ma Xing Shi Gan Decoction against COVID-19 through Integrating Network Pharmacology and Experimental Exploration</strong> - The outbreak of new infectious pneumonia caused by SARS-CoV-2 has posed a significant threat to public health, but specific medicines and vaccines are still being developed. Traditional Chinese medicine (TCM) has thousands of years of experience in facing the epidemic disease, such as influenza and viral pneumonia. In this study, we revealed the efficacy and pharmacological mechanism of Ma Xing Shi Gan (MXSG) Decoction against COVID-19. First, we used liquid chromatography-electrospray...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Taming the Autophagy as a Strategy for Treating COVID-19</strong> - Currently, an efficient treatment for COVID-19 is still unavailable, and people are continuing to die from complications associated with SARS-CoV-2 infection. Thus, the development of new therapeutic approaches is urgently needed, and one alternative is to target the mechanisms of autophagy. Due to its multifaceted role in physiological processes, many questions remain unanswered about the possible advantages of inhibiting or activating autophagy. Based on a search of the literature in this...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>A Computer-Aided Drug Design Approach to Predict Marine Drug-Like Leads for SARS-CoV-2 Main Protease Inhibition</strong> - The investigation of marine natural products (MNPs) as key resources for the discovery of drugs to mitigate the COVID-19 pandemic is a developing field. In this work, computer-aided drug design (CADD) approaches comprising ligand- and structure-based methods were explored for predicting SARS-CoV-2 main protease (M^(pro)) inhibitors. The CADD ligand-based method used a quantitative structure-activity relationship (QSAR) classification model that was built using 5276 organic molecules extracted...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The role of extracellular DNA in COVID-19: clues from inflamm-aging</strong> - Epidemiological data convey severe prognosis and high mortality rate for COVID-19 in elderly men affected by age-related diseases. These subjects develop local and systemic hyper-inflammation, which are associated with thrombotic complications and multi-organ failure. Therefore, understanding SARS-CoV-2 induced hyper-inflammation in elderly men is a pressing need. Here we focus on the role of extracellular DNA, mainly mitochondrial DNA (mtDNA) and telomeric DNA (telDNA) in the modulation of...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Dual Targeting of 3CL(pro) and PL(pro) of SARS-CoV-2: A Novel Structure-Based Design Approach to treat COVID-19</strong> - With the rapid growth of the COVID-19 (coronavirus disease 2019) pandemic across the globe, therapeutic attention must be directed to fight the novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). However, developing new antiviral drugs and vaccine development is time-consuming, so one of the best solutions to tackle this virus at present is to repurpose ready-to-use drugs. This paper proposes the repurposing of the Food and Drug Administration (FDA)-approved, purchasable, and...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2</strong> - The SARS-CoV-2 infection is spreading rapidly worldwide. Efficacious antiviral therapeutics against SARS-CoV-2 is urgently needed. Here, we discovered that protoporphyrin IX (PpIX) and verteporfin, two FDA-approved drugs, completely inhibited the cytopathic effect produced by SARS-CoV-2 infection at 1.25 µmol/Land 0.31 µmol/L respectively, and their EC50 values of reduction of viral RNA were at nanomolar concentrations. The selectivity indices of PpIX and verteporfin were 952.74 and 368.93,...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses</strong> - In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in SARS-Cov2 infection. We discuss the current literature on mTOR in SARS-Cov2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of...</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection</strong> - The coronavirus disease 2019 (COVID-19) pandemic is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is spread primary via respiratory droplets and infects the lungs. Currently widely used cell lines and animals are unable to accurately mimic human physiological conditions because of the abnormal status of cell lines (transformed or cancer cells) and species differences between animals and humans. Organoids are stem cell-derived self-organized...</p></li>
</ul>
<h1 data-aos="fade-right" id="from-patent-search">From Patent Search</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>"AYURVEDIC PROPRIETARY MEDICINE FOR TREATMENT OF SEVERWE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2."</strong> - AbstractAyurvedic Proprietary Medicine for treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)In one of the aspect of the present invention it is provided that Polyherbal combinations called Coufex (syrup) is prepared as Ayurvedic Proprietary Medicine , Aqueous Extracts Mixing with Sugar Syrup form the following herbal aqueous extract coriandrum sativum was used for the formulation of protek.Further another Polyherbal combination protek as syrup is prepared by the combining an aqueous extract of the medicinal herbs including Emblica officinalis, Terminalia chebula, Terminalia belerica, Aegle marmelos, Zingiber officinale, Ocimum sanctum, Adatoda zeylanica, Piper lingum, Andrographis panivulata, Coriandrum sativum, Tinospora cordiofolia, cuminum cyminum,piper nigrum was used for the formulation of Coufex.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Haptens, hapten conjugates, compositions thereof and method for their preparation and use</strong> - A method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described. One embodiment comprised contacting the sample with two or more specific binding moieties that bind specifically to two or more different targets. The two or more specific binding moieties are conjugated to different haptens, and at least one of the haptens is an oxazole, a pyrazole, a thiazole, a nitroaryl compound other than dinitrophenyl, a benzofurazan, a triterpene, a urea, a thiourea, a rotenoid, a coumarin, a cyclolignan, a heterobiaryl, an azo aryl, or a benzodiazepine. The sample is contacted with two or more different anti-hapten antibodies that can be detected separately. The two or more different anti-hapten antibodies may be conjugated to different detectable labels.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>疫苗融合蛋白</strong> - 本申请涉及一种融合蛋白，所述融合蛋白包括SARS‑CoV‑2抗原多肽和鞭毛蛋白或其片段。本申请还提供了所述融合蛋白的制备方法和用途。本申请所述的融合蛋白能够诱导机体产生针对SARS‑CoV类病毒的抗原的细胞免疫反应。</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>AN EFFICIENT METHODOLOGY TO MANAGE THE ADMISSIONS IN HOSPITALS DURING THE PANDEMICS SUCH AS COVID 19</strong> -</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种SARS-CoV-2假病毒小鼠体内包装系统及其制备方法</strong> - 本发明提供了一种假病毒小鼠体内包装系统的制备方法，包括以下步骤：S1基于慢病毒包装质粒系统和睡美人转座子系统构建SARS‑CoV‑2假病毒包装质粒系统，S2将步骤S1中SARS‑CoV‑2假病毒包装质粒系统与睡美人转座酶表达质粒混合通过水动力注射的方式转染小鼠肝细胞，然后睡美人转座子系统将SARS‑CoV‑2假病毒包装所需序列以剪切粘贴的方式整合到小鼠肝细胞的基因组。本发明可在小鼠体内持续制造分泌SARS‑CoV‑2假病毒，可模拟靶器官被SARS‑CoV‑2病毒持续侵入攻击的过程，从而可模拟出新冠肺炎（COVID‑19）的病理特征。基于SARS‑CoV‑2假病毒小鼠体内包装系统的动物模型安全性高，不需要P3级实验室就能开展研究。利用水动力注射的方式引入SARS‑CoV‑2假病毒包装质粒系统操作简单，成本低。</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>柴胡解毒药物组合物及其制备方法和应用</strong> - 本发明属于中药领域，具体涉及一种柴胡解毒药物组合物及其制备方法和应用，所述柴胡解毒药物组合物以质量份计由如下原料组分制成：柴胡30<sub>60份，黄芩15</sub>30份，法半夏15<sub>30份，生姜15</sub>30份，大枣5<sub>10份，枳实20</sub>40份，大黄10<sub>20份，桃仁10</sub>20份，白芍15~30份。本发明的柴胡解毒药物组合物能够显著改善普通型COVID‑19引起的咳嗽；能改善疫毒闭肺型重型COVID‑19引起的咳嗽，显著改善疫毒闭肺型重型COVID‑19引起的胸闷、气短和乏力等主要症状。另外经大量临床观察，本发明的柴胡解毒药物组合物能够显著改善疫毒闭肺型重型COVID‑19引起的发热面红，咳嗽，痰黄粘少，或痰中带血，喘憋气促，疲乏倦怠，口干苦粘，大便不畅，小便短赤等症状。</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>一种新型冠状病毒RBD核苷酸序列、优化方法与应用</strong> - 本发明公开了一种新型冠状病毒RBD核苷酸序列、优化方法与应用。属于基因工程技术领域。优化步骤：（1）对野生型新型冠状病毒RBD核苷酸序列进行初步优化；（2）将宿主细胞特异性高表达分泌蛋白信号肽序列进行优化；（3）将人IgG1‑Fc核苷酸序列进行优化；（4）将步骤（2）优化后的宿主细胞特异性高表达分泌蛋白信号肽核苷酸序列、步骤（1）得到的初步优化新型冠状病毒RBD核苷酸序列、连接子核苷酸序列和步骤（3）优化后的人IgG1‑Fc核苷酸序列依次连接即可。与现有技术相比，本发明的有益效果：产生的克隆表达效率比野生新型冠状病毒RBD序列提高了约12倍，比中国仓鼠密码子偏性优化序列克隆表达效率提高了2倍。</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ASSISTING COMPLEX FOR TAKING OF BIOMATERIAL FROM MOUTH IN PANDEMIC CONDITIONS</strong> - FIELD: medicine. SUBSTANCE: invention refers to medicine, namely to methods for contactless taking of biomaterial in tested person. Taking the biomaterial in the tested person is carried out in a room located in a dirty zone and separated by a partition from the clean zone, in which there is a laboratory assistant performing the procedure using a robotic complex. Complex includes digital controller, manipulator with tool unit, small manipulator, camera, monitor, control system of digital controller, manipulator, small manipulator, and complex control system. In the partition there are two holes: one – for installation and passage of the swab, the other – for the test tube installation. In the dirty zone there is a small manipulator having two actuators: one for movement of a test tube with a swab, and the second for positioning and placing a disposable mouthpiece. EFFECT: reduced risk of laboratory assistant and tested person infection by avoiding their direct contact. 17 cl, 1 dwg</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiinfektive Arzneiform zur Herstellung einer Nasenspülung gegen COVID-19</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Einzeldosierte, wasserlösliche oder wassermischbare Arzneiform, umfassend mindestens einen antiinfektiven Arzneistoff, zur Herstellung einer Nasenspülung und/oder zur Verwendung in der lokalen Behandlung des menschlichen Nasenraums.
</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Antiinfektive Arzneiform zur Herstellung einer Nasenspülung gegen COVID-19</strong> -
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Einzeldosierte, wasserlösliche oder wassermischbare Arzneiform, umfassend mindestens einen antiinfektiven Arzneistoff, zur Herstellung einer Nasenspülung und/oder zur Verwendung in der lokalen Behandlung des menschlichen Nasenraums.
</p></li>
</ul>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
<ul>
<li><a href="#from-new-yorker">From New Yorker</a></li>
<li><a href="#from-vox">From Vox</a></li>
<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
<li><a href="#from-ars-technica">From Ars Technica</a></li>
<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
</ul>
<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>America Is Running Out of Nurses</strong> - Travelling nurses have been moving from one hot spot to another. What happens when the hot spots keep multiplying? - <a href="https://www.newyorker.com/science/medical-dispatch/america-is-running-out-of-nurses">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Trump’s Coup Attempt Isn’t Over</strong> - A challenge to the election result on the floor of Congress is guaranteed to fail, but it will afford Republicans a loud show of doing something to “stop the steal.” - <a href="https://www.newyorker.com/news/our-columnists/trumps-coup-attempt-isnt-over">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Overlooked Hallmark of the Trump Administration—and Other Autocracies</strong> - We generally understand the President’s failures as the products of cruelty and incompetence. But there is a third source: indifference. - <a href="https://www.newyorker.com/news/our-columnists/the-overlooked-hallmark-of-the-trump-administration-and-other-autocracies">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>William Barr Is Going, But His Trumpian Legacy Remains</strong> - The Attorney General showed a willingness to act in a nakedly partisan manner. - <a href="https://www.newyorker.com/news/daily-comment/william-barr-is-going-but-his-trumpian-legacy-remains">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Our Stuff Weighs More Than All Living Things on the Planet</strong> - This year, the weight of all “human-made mass” exceeded that of the earth’s entire biomass. We now live on Planet Stuff. - <a href="https://www.newyorker.com/news/annals-of-a-warming-planet/our-stuff-weighs-more-than-all-living-things-on-the-planet">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google got hit with another huge antitrust case, this time over its ad monopoly</strong> -
<figure>
<img alt="Google logo with a spotlight over it." src="https://cdn.vox-cdn.com/thumbor/A4BjdsOYxfmMCSEcibxQZpCS-qY=/33x0:3589x2667/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68525955/1195196916.0.jpg"/>
<figcaption>
Google is in the spotlight again. | Fabrice Coffrini/AFP via Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Google has ruled the online ad marketplace for years. Now it faces 10 state attorneys general over its dominance.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="MPV6S9">
A group of 10 state attorneys general filed suit against Google on Wednesday, alleging anti-competitive practices related to its ad technology. Texas Attorney General Ken Paxton, a Republican, led the investigation into Google and announced the lawsuit <a href="https://twitter.com/TXAG/status/1339283520099856384?s=20">in a video posted to Twitter</a> a few hours before the lawsuit was filed.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UX03Wq">
“Google repeatedly used its monopolistic power to control pricing, engage in market collusions to rig auctions in a tremendous violation of justice,” Paxton said in the video.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yYvNhu">
<a href="https://www.texasattorneygeneral.gov/sites/default/files/images/admin/2020/Press/20201216%20COMPLAINT_REDACTED.pdf">The lawsuit</a>, which is one of several antitrust cases Google now faces, alleges that Google engaged in a wide variety of anti-competitive behavior to create and maintain its monopoly power in digital ad markets and keep out competitors. It also alleges that Google and Facebook illegally agreed not to compete with each other. This latest legal action is happening after Google and other big tech companies like Facebook have for years been accused of employing anti-competitive practices.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8oN4iW">
“In addition to representing both the buyers and the sellers of online display advertising, Google also operates the largest exchange AdX,” reads the lawsuit, which was filed by Republican attorneys general in Arkansas, Idaho, Indiana, Mississippi, Missouri, North Dakota, South Dakota, Utah, and Kentucky, as well as Texas. “In this electronically traded market, Google is pitcher, batter, and umpire, all at the same time.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="KYrO74">
This is akin to the New York Stock Exchange also controlling the buying and selling of stocks, according to Sally Hubbard, director of enforcement strategy at the Open Markets Institute and author of <em>Monopolies Suck</em>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xTFGTf">
“They’re getting information that they shouldn’t have if the market is supposed to be properly functioning,” Hubbard told Recode. “We don’t tolerate this in other sectors.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1OOiUy">
Google didn’t respond to a request for comment. Google spokesperson Julie McAlister <a href="https://www.nytimes.com/2020/12/16/technology/google-monopoly-antitrust.html">told the New York Times</a> that “Attorney General Paxton’s ad tech claims are meritless” and that the company “will strongly defend ourselves from his baseless claims in court.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DX6w6i">
This lawsuit is the first to focus on Google’s dominance in ad tech. More specifically, it <a href="https://www.texasattorneygeneral.gov/sites/default/files/images/admin/2020/Press/20201216%20COMPLAINT_REDACTED.pdf">says</a> that Google uses its market power to “extract a very high tax of [redacted] percent of the ad dollars otherwise flowing to the countless online publishers and content producers like online newspapers, cooking websites, and blogs who survive by selling advertisements on their websites and apps.” In turn, these businesses pass costs on to consumers, causing them harm, according to the lawsuit.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="S92Y52">
Last year, Google <a href="https://abc.xyz/investor/static/pdf/2019Q4_alphabet_earnings_release.pdf?cache=79552b8#:~:text=%E2%80%9CIn%202019%20we%20again%20delivered,Officer%20of%20Alphabet%20and%20Google.">brought in nearly $162 billion</a> in revenue, the vast majority of which came from advertising. Google controls nearly a third of all digital ad spending in the US, according to eMarketer. Since its tools dominate all parts of the ad process, Google is said to have unfair visibility that allows it to maintain its dominance, according to the <a href="https://www.wsj.com/articles/how-google-edged-out-rivals-and-built-the-worlds-dominant-ad-machine-a-visual-guide-11573142071">Wall Street Journal’s Keach Hagey and Vivien Ngo</a>, who last year explained how Google’s ad tech works and why publishers and rivals have long complained about it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BTedGd">
This lawsuit is the latest in a series of antitrust suits against Big Tech, including one filed against Google in October by the <a href="https://www.vox.com/recode/21524710/google-antitrust-lawsuit-doj-search-trump-bill-barr">Justice Department</a> and 11 states. The DOJ alleged that Google used its search dominance to preserve its other monopolies, including advertising. <a href="https://www.politico.com/news/2020/12/15/states-google-antitrust-lawsuit-445950">A bipartisan lawsuit</a> regarding Google’s monopolization of specialized search like maps and reviews is expected soon from attorneys general from Colorado and Nebraska. Earlier this month, the Federal Trade Commission and 48 states filed a <a href="https://www.vox.com/recode/22166437/facebook-instagram-ftc-attorneys-general-antitrust-monopoly-whatsapp">suit against Facebook</a>, saying that its acquisitions of Instagram and WhatsApp amounted to anti-competitive practices that harm consumers.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iHxO65">
Meanwhile, Paxton, the Texas attorney general, has recently made news for filing a <a href="https://www.texastribune.org/2020/12/08/texas-ken-paxton-election-georgia/">specious lawsuit</a> against swing states in an effort to overturn the results of the presidential election. He lost the lawsuit but, <a href="https://www.theatlantic.com/ideas/archive/2020/12/how-texass-attorney-general-won-by-losing-big/617388/">the Atlantic argues</a>, won in an effort to bolster his political career and distract from his own legal troubles, including securities fraud and felony counts he faces for allegedly trying to get investors to buy stock in a company without telling them he got a commission for it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JfXfV6">
Antitrust cases are notoriously difficult to win, but the sheer number of them arising this year against Big Tech suggests the government at least thinks there’s a chance.
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Twitter joins Facebook and YouTube in banning Covid-19 vaccine misinformation</strong> -
<figure>
<img alt="" src="https://cdn.vox-cdn.com/thumbor/dz78DK9GNGIolN2GTTdGf4uYDCo=/585x0:5264x3509/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68525942/1229659282.0.jpg"/>
<figcaption>
Jack Dorsey, the CEO of Twitter, recently testified to the Senate Judiciary Committee. | Hannah McKay/Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The move comes as false rumors about Covid-19 vaccines are surging online.
</p>
<div class="c-float-left">
<figure class="e-image">
<pre><code> &lt;img alt="Open Sourced logo" src="https://cdn.vox-cdn.com/thumbor/lcj6gww0ZKRDdVz0qOCNWvVxgYw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/19433750/open_sourced_story_logo.png" /&gt;</code></pre>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ld5WTN">
On Wednesday, Twitter <a href="https://blog.twitter.com/en_us/topics/company/2020/covid19-vaccine.html">announced</a> that it will begin to take down Covid-19 vaccine misinformation starting next week. The company plans to remove false vaccine content that it considers “the most harmful,” and later on it will start labeling other posts that could be misleading.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kH7SAI">
“In the context of a global pandemic, vaccine misinformation presents a significant and growing public health challenge — and we all have a role to play,” the company said in <a href="https://blog.twitter.com/en_us/topics/company/2020/covid19-vaccine.html">a blog post</a>. “We are focused on mitigating misleading information that presents the biggest potential harm to people’s health and wellbeing.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eFJP2n">
Twitter’s announcement follows similar pledges from both Facebook and YouTube, which recently said they’ll remove false information related to Covid-19 vaccines. The announcement also comes after the US Food and Drug Administration’s <a href="https://www.vox.com/22167841/fda-vaccine-approval-pfizer-biontech-covid-19-eua-coronavirus">authorization of the vaccine developed by Pfizer and BioNTech</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="SXx0Nm">
As the Pfizer/BioNTech vaccine begins to be <a href="https://www.vox.com/2020/12/14/22174004/pfizer-first-vaccine-covid-19-begins-biontech-coronavirus">administered</a> to health care workers and people in long-term care homes, <a href="https://www.nytimes.com/2020/12/16/technology/from-voter-fraud-to-vaccine-lies-misinformation-peddlers-shift-gears.html">misinformation related to vaccines</a> has flourished online. For instance, unproven narratives that the Covid-19 vaccine has links to the Chinese Communist Party, or that the vaccine has a proven connection to a condition called Bell’s palsy, have gained tens of thousands of mentions in the past week, according to data collected by Zignal Labs.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9LnIRI">
This surge of misinformation has exacerbated concerns that part of the US population may be unwilling to get the vaccine, or will delay doing so. Recent polling suggests that while most Americans say they’ll probably or definitely get vaccinated against Covid-19, many may <a href="https://www.cnn.com/2020/12/15/health/survey-covid-vaccine-kaiser-monitor/index.html">not do so immediately</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="OJkNxo">
In a blog post, Twitter explained that it will take a two-pronged approach to vaccine content: taking down misinformation that poses the most harm while labeling content that’s misleading or out of context. Posts that could be removed, the company says, include anything that suggests that a Covid-19 vaccine is part of a “deliberate conspiracy” or that falsely claims Covid-19 is a hoax and so vaccines aren’t necessary. The company also said it would tackle misinformation related to vaccines more generally, including claims that have been “widely debunked about the adverse impacts or effects of receiving vaccinations.”
</p>
<aside id="tMHjIZ">
<div>
</div>
</aside>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vmaBlu">
A Twitter spokesperson told Recode that when someone posts this type of misinformation, the platform will hide that content from public view. The person who posted it can then appeal the decision to Twitter or log on and remove that content themselves before they’ll be allowed to post again from their account.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uzuEl5">
Beginning next year, Twitter will also start adding labels to posts that the platform decides need further context, like rumors, contested claims, or claims about the Covid-19 vaccine that are “incomplete.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="oHMSwA">
Back in October, YouTube announced that it planned to remove Covid-19 vaccine misinformation, and it <a href="https://www.theverge.com/2020/10/14/21515796/youtube-covid-vaccine-misniformation-policy">banned vaccine claims</a> that went against what health experts and the World Health Organization said.
</p>
<div id="2YSF5F">
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f46Zpc">
Earlier this month, <a href="https://about.fb.com/news/2020/12/coronavirus/#removing-covid-vaccine-misinformation">Facebook</a> said that under its policy requiring the removal of content that could lead to “imminent physical harm,” it too would remove false information related to Covid-19 vaccines. For instance, the company said it would take down content that said vaccines include microchips — a common and false <a href="https://www.cnbc.com/2020/07/22/bill-gates-denies-conspiracy-theories-that-say-he-wants-to-use-coronavirus-vaccines-to-implant-tracking-devices.html">conspiracy theory related to the Covid-19 vaccine</a>. It’s also removing posts that claim that “specific populations are being used without their consent to test the vaccine’s safety.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pdTYsL">
Just a month ago, Twitter had told Recode that while it recognized the importance of its platform to public health, it was <a href="https://www.vox.com/recode/21527013/covid-19-vaccine-pfizer-safety-social-media-misinformation">still working out</a> how it would approach moderating content surrounding a Covid-19 vaccine. Twitter would not comment on whether it worked with the other social media companies in developing the policies announced today.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YkfnAA">
Throughout the pandemic, Twitter has used a sliding scale between posts that deserve a label and <a href="https://www.vox.com/recode/2020/5/11/21254889/twitter-coronavirus-covid-misinformation-warnings-labels">posts that require removal</a>, depending on how harmful that content could be. The company has also <a href="https://www.vox.com/recode/2020/11/4/21548733/trump-stolen-election-twitter-facebook-label">frequently used labels</a> on posts sharing election misinformation.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="6sfE9D">
Twitter’s new rules on vaccine misinformation suggest the fight against this problem is likely to continue. In fact, many of the same accounts that have pushed other types of false claims, like election misinformation, are now <a href="https://www.nytimes.com/live/2020/12/16/us/joe-biden-trump#misinformation-messengers-pivot-from-election-fraud-to-peddling-vaccine-conspiracy-theories">turning their attention</a> toward the Covid-19 vaccine, indicating a significant challenge ahead for social media platforms.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WnIQrT">
<a href="http://www.vox.com/open-sourced"><em>Open Sourced</em></a><em> is made possible by Omidyar Network. All Open Sourced content is editorially independent and produced by our journalists.</em>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IaG4sm">
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QZxAEM">
</p>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Ron Johnson turned the Senate into a platform for discredited election conspiracy theories</strong> -
<figure>
<img alt="Senate Homeland Security Committee Hears Testimony On Irregularities In 2020 Election" src="https://cdn.vox-cdn.com/thumbor/fmI3ntVaUo0N5sEeWx6AEjsrJXw=/42x0:2709x2000/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68525601/1230159853.0.jpg"/>
<figcaption>
Johnson (right) bumps arms with Chris Krebs following Wednesday’s hearing. | Greg Nash-Pool/Getty Images
</figcaption>
</figure></li>
</ul>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Chris Krebs stole the show.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="vZPzeh">
<a href="https://www.wisn.com/article/sen-ron-johnson-acknowledges-biden-victory-leads-election-fraud-investigation/34982540">Sen. Ron Johnson (R-WI)</a> and a group of other Senate Republicans <a href="https://www.vox.com/2020/12/15/22176253/joe-biden-senate-republicans-victory-presidential-election-mitch-mcconnell-trump-results">finally acknowledged Joe Biden’s victory</a> this week — and then Johnson’s Homeland Security and Governmental Affairs Committee held a Wednesday hearing aimed at undermining it.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2yJx5I">
Biden’s decisive Electoral College victory on Monday forced Johnson and some of his Republican colleagues to belatedly recognize the reality of President Donald Trump’s defeat, after weeks of suggesting Trump might still somehow be declared the winner of November’s election. Now unable to deny Biden will be the next president, the hearing basically served as a platform for Republicans to lie about Biden’s win being tainted.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="4Q0euk">
“The election in many ways was stolen,” claimed Sen. Rand Paul (R-KY) at one point, in the bluntest example of how Republicans tried turning reality on its head.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PKjKoR">
But Paul didn’t even try to offer evidence to back his assertion up. And state officials spanning the political spectrum have one and all <a href="https://www.nytimes.com/2020/11/10/us/politics/voting-fraud.html">reported no irregularities</a> that affected the result — many swing states held multiple recounts to ensure that this was the case.
</p>
<div id="3Oi3AY">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
"The election in many ways was stolen," Rand Paul lies, citing no evidence <a href="https://t.co/G4m7mU7qRV">pic.twitter.com/G4m7mU7qRV</a>
</p>
— Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1339247653461352448?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="N2ETI2">
The witness list illustrated how Johnson tried to stack the deck. Among them were two attorneys for the Trump campaign, a Republican state legislator from Pennsylvania, and Ken Starr, the former Bill Clinton investigator who is perhaps best known these days as a Trump-friendly talking head on Fox News.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="HWJkgE">
All of those witnesses either had obvious bias or little to no firsthand information about the security of the 2020 election. But the exception to that was Chris Krebs, the former head of the Homeland Security Department’s Cybersecurity and Infrastructure Security Agency (CISA) who <a href="https://www.vox.com/2020/11/18/21573119/chris-krebs-trump-fired-dhs-cisa-election-security">Trump fired by tweet</a> last month after he refuted Trump’s lies and conspiracy theories by calling the election <a href="https://www.vox.com/2020/11/13/21563825/2020-elections-most-secure-dhs-cisa-krebs">“the most secure in American history.”</a>
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Eg4JhR">
Krebs, a Republican, repeatedly knocked down suggestions from Johnson and others that the election results were somehow manipulated by pointing out that the counts in all the states the Trump campaign contested are backed up by paper ballots.
</p>
<div id="8AySij">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Ron Johnson looks like he has indigestion as Krebs denounces Republican election fraud lies that have resulted in him and other officials receiving threats <a href="https://t.co/hVjVwp1rVN">pic.twitter.com/hVjVwp1rVN</a>
</p>
— Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1339254506211717127?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="1XjeZR">
“It’s important to step back and actually look at how votes are cast in the country, particularly with paper ballots, and that regardless of any internet connections, regardless of foreign hacking, as long as you’ve got the paper receipt ... you can check your math.”
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tweet-text">
“Georgia did that three times and the outcomes were consistent,” Krebs added, alluding to the <a href="https://www.vox.com/2020/12/5/22155858/georgia-election-lawsuit-trump-recount">repeated recounts in Georgia</a> that all showed Biden defeating Trump.
</p>
<div id="tLZ7WJ">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Krebs: "That's why it's so important to have a paper trail &amp; paper ballots. So even if there was foreign interference of a malicious algorithm nature, you can go back to the receipts. You can check your math, and Georgia did that 3 times &amp; the outcomes were consistent." <a href="https://t.co/1Rq4FYnCsO">pic.twitter.com/1Rq4FYnCsO</a>
</p>
— Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1339244260638552068?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yyrzia">
Krebs tried to patiently explain the safeguards that were in place to prevent election fraud, but at other points he didn’t try to hide the fact that he thinks Republicans needs to move on.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7OKLhZ">
“I think we’re past the point where we need to be having conversations about the outcome of this election,” Krebs said, adding later: “We have to stop this. It’s undermining confidence in democracy.”
</p>
<h3 id="2mWZcc">
Much of Johnson’s hearing could’ve been mistaken for a Fox News segment
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Ikp904">
The ranking member of the Homeland Security Committee, Sen. Gary Peters (D-MI), began the hearing by castigating Republicans for wasting time with a hearing aimed at delegitimizing President-elect Biden in particular and US elections in general.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bpok0H">
“Whether intended or not, this hearing gives a platform to conspiracy theories and lies and is a destructive exercise that has no place in the US Senate. Joe Biden won the election,” Peters said during his opening statement.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="XQuYyC">
“There were no widespread election irregularities that affected the final outcome. These claims are false. And giving them more oxygen is a grave threat to the future of our democracy,” he added.
</p>
<div id="5czkj5">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Peters: "There were no widespread election irregularities that affected the final outcome. These claims are false. And giving them more oxygen is a grave threat to the future of our democracy... we have seen democracies around the world crumble b/c of similar words and actions." <a href="https://t.co/ioGyB1Qxkr">pic.twitter.com/ioGyB1Qxkr</a>
</p>
— Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1339230170360721409?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="lPV8a7">
But those comments didn’t sit well with Johnson, who called them “galling” and sparked a heated exchange with Peters by calling him a liar.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ug4NaS">
“This is not about airing your grievances,” Peters fired back, prompting Johnson to repeatedly bang his gavel in an effort to silence him.
</p>
<div id="uoY5Cb">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
A very heated moment between Ron Johnson and Gary Peters <a href="https://t.co/e1zuGb9Kbr">pic.twitter.com/e1zuGb9Kbr</a>
</p>
— Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1339244996273311744?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jqt1P1">
In fact, Johnson’s hearing did appear to be mostly about airing grievances. For instance, Sen. Josh Hawley (R-MO) made a case that Republicans raising conspiratorial questions about the election results is no different from Democrats’ “Russia hoax.” An important difference, however, is that while there’s <a href="https://www.vox.com/2018/6/11/17438386/trump-russia-collusion">lots of evidence the Trump campaign colluded with Russia</a>, there’s no evidence of significant election irregularities.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tnga3t">
Hawley also shared that “yesterday I was talking with some of the constituents back at home — a group of about 30 people — every single one of them, every one of them, told me that they felt they had been disenfranchised, that their votes didn’t matter, that the election had been rigged. These are normal, reasonable people, these are not crazy people.”
</p>
<div id="NSamZd">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Josh Hawley's "these are not crazy people" shirt raises a lot of questions answered by his shirt <a href="https://t.co/tikoLawsyG">pic.twitter.com/tikoLawsyG</a>
</p>
— Aaron Rupar (<span class="citation">@atrupar</span>) <a href="https://twitter.com/atrupar/status/1339263949775245330?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VjiW8h">
But the fact that Trump voters believe the conspiracy theories Republicans have been pushing about election fraud is not evidence that they’re true. And when Republicans have been challenged in courtrooms and elsewhere to produce evidence that rises beyond insinuation and anecdote, <a href="https://www.washingtonpost.com/politics/2020/12/14/there-is-not-has-not-been-any-credible-evidence-significant-fraud-2020-election/">they’ve come up with nothing</a>.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="qOn7Dn">
If there was any doubt that Hawley’s comments about election fraud were coming from a place of bad faith, it was resolved by the fact that he directed each of the string of loaded questions he asked to cable news talking head Ken Starr — and not a single one to Krebs, the witness with by far the most firsthand information about the election.
</p>
<h3 id="HVmxgb">
By pandering to Trump, Republicans are putting themselves in bind
</h3>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rNog4O">
Even as more Republicans succumb to the reality of Biden’s win, Wednesday’s hearing illustrated how many of them continue to try to curry favor with Trump, whose lies about the election continue to get more outlandish.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="bx6SQW">
On Tuesday night, for instance, Trump tweeted a debunked conspiracy theory about voting machines switching votes from Trump to Biden — a claim <a href="https://www.usatoday.com/story/news/factcheck/2020/11/14/fact-check-dominion-voting-machines-didnt-delete-switch-votes/6282157002/">not backed up</a> by any of the recounts that have taken place, including <a href="https://sos.ga.gov/index.php/elections/historic_first_statewide_audit_of_paper_ballots_upholds_result_of_presidential_race">recounts of the paper ballots</a> Krebs mentioned.
</p>
<div id="SNlbax">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
“Study: Dominion Machines shifted 2-3% of Trump Votes to Biden. Far more votes than needed to sway election.” Florida, Ohio, Texas and many other states were won by even greater margins than projected. Did just as well with Swing States, but bad things happened. <a href="https://twitter.com/OANN?ref_src=twsrc%5Etfw"><span class="citation">@OANN</span></a>
</p>
— Donald J. Trump (<span class="citation">@realDonaldTrump</span>) <a href="https://twitter.com/realDonaldTrump/status/1339090279429775363?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Wv7VIx">
As if on cue, Trump wasted no time after the hearing ended highlighting how effortlessly he lies about anything and everything. He tweeted that Krebs “was totally excoriated and proven wrong at the Senate Hearing,” even though anyone who watched it knows that nothing of the sort happened.
</p>
<div id="OhX6hN">
<blockquote class="twitter-tweet">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" dir="ltr" lang="en">
Chris Krebs was totally excoriated and proven wrong at the Senate Hearing on the Fraudulent 2020 Election. Massive FRAUD took place with machines, people voting from out of state, illegals, dead people, no signatures—and so much more!
</p>
— Donald J. Trump (<span class="citation">@realDonaldTrump</span>) <a href="https://twitter.com/realDonaldTrump/status/1339281950490697729?ref_src=twsrc%5Etfw">December 16, 2020</a>
</blockquote>
</div>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f758TS">
The defeated president has obvious self-interested reasons for falsely insisting that he only lost because of cheating, but Republican senators are playing a dangerous game. Not only are they delegitimizing US elections, but they’re running the risk of demoralizing Republicans votes who are being told voting doesn’t matter because election results are predetermined.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="kvTi7B">
Just weeks ahead of Georgia runoffs in which control of the US Senate is at stake, the conspiracy theories Republicans like Johnson, Paul, and Hawley are pushing <a href="https://www.vox.com/2020/12/15/22176161/trump-perdue-loeffer-rigged-election-runoffs">could do serious damage to their cause</a>. But whether they’re thinking beyond crafting the perfect 30-second soundbite for Sean Hannity’s Fox News show is unclear.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="M7HKHa">
</p>
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>How India’s long-distance running community coped with the pandemic</strong> - With most running evens cancelled or postponed this year, runners kept themselves active by participating in virtual marathons and training inside their homes</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>India pledges $1 million to WADA for scientific research</strong> - India’s donation comes at a time when the country’s anti-doping programme has been adversely affected by suspension of its suspended National Dope Testing Laboratory, which is to be inspected by WADA early next year.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Pakistan’s Mohammed Amir quits cricket alleging ‘mental torture’ by PCB</strong> - Amir was a part of the Pakistan squad which won the 2009 World T20 Cup and was also there when they won the Champions Trophy title in 2017.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Track cycling standout Fabian Puerta gets 4-year doping ban</strong> - He tested positive for the banned substance boldenone.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Yogasana recognised as a competitive sport in India</strong> - ‘Work is currently on to develop a patented electronic scoring system for yogasana championships in India and globally’</p></li>
</ul>
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Plea for NDMA collecting data on financial stress caused by pandemic</strong> - Resolution of financial debts cannot be left solely in the hands of individual banks and their policies: petitioner</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Data | Progress on child nutrition derailed as wasting and stunting increases in several States</strong> - In Gujarat, Maharashtra and West Bengal, the share of anaemic and wasted children was significantly higher than the levels recorded 15 years before</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>JD(U) throws hat in the ring for West Bengal assembly polls</strong> - ‘The party’s unit in West Bengal wants to contest at least 75 seats and the number could go up, subject to the approval of the leadership’</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>UDF scores in municipalities</strong> - The United Democratic Front (UDF), which had a tough ride in the 2020 local body elections, managed to put up a good show in the municipalities. As pe</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>COVID-19 vaccine pricing to help governments to ensure little to no out-of-pocket costs for people: Pfizer</strong> - For this pandemic period, the company’s pricing approach is based on the principle of ensuring broad access and supplies to the governments, a Pfizer spokesperson said in a statement.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
<ul>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Emmanuel Macron: French president tests positive for Covid</strong> - The 42-year-old took a test after experiencing symptoms and will now self-isolate for seven days.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus: Swedish King Carl XVI Gustaf says coronavirus approach 'has failed'</strong> - Sweden has been criticised for its more relaxed approach to handling the pandemic.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Russia's Putin calls Navalny poisoning inquiry 'a trick'</strong> - Russia's president scorns a report alleging that agents poisoned opposition leader Alexei Navalny.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Charlie Hebdo: Fourteen guilty in 2015 Paris terror attacks trial</strong> - The deadly attacks on Charlie Hebdo magazine and a Jewish supermarket shook France.</p></li>
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lockerbie bombing: New suspect soon to be charged - US media</strong> - The US will announce charges against a suspected bomb-maker behind the 1988 disaster, US media report.</p></li>
</ul>
<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
<ul>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>“Evil mobile emulator farms” used to steal millions from US and EU banks</strong> - Scale of operation is unlike anything researchers had seen before. - <a href="https://arstechnica.com/?p=1730284">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>As the world quieted down in 2020, Raspberry Shakes listened</strong> - Humble Raspberry Pis helped scientists track the seismic noise people stopped making in 2020. - <a href="https://arstechnica.com/?p=1730053">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>HBO Max patches its Roku hole six months after launch</strong> - Adds over 100 million potential users; follows deals for PlayStation 5, Amazon Fire. - <a href="https://arstechnica.com/?p=1730273">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Qualcomm promises three years of Android updates for its entire SoC lineup</strong> - The new plan is three years of major OS updates and four years of security updates. - <a href="https://arstechnica.com/?p=1730192">link</a></p></li>
<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Google bought CloudReady, the largest ChromiumOS distribution</strong> - Google says it will continue to offer the free-as-in-beer Home edition. - <a href="https://arstechnica.com/?p=1730241">link</a></p></li>
</ul>
<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
<ul>
<li><strong>An elderly man is stopped by the police around 2 a.m. and is asked where he is going at this time of night. The man replies, "I am on my way to a lecture about alcohol abuse and the effects it has on the human body, as well as smoking and staying out late."</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The officer then asks, "Really? Who is giving that lecture at this time of night?" The man replies, "That would be my wife."
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/YZXFILE"> /u/YZXFILE </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/keidv1/an_elderly_man_is_stopped_by_the_police_around_2/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/keidv1/an_elderly_man_is_stopped_by_the_police_around_2/">[comments]</a></span></p></li>
<li><strong>Today I saw an ad that said "radio for sale, $1, volume knob stuck on full."</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
I thought, "I can't turn that down."
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/KittysOnKeyboarghjfg"> /u/KittysOnKeyboarghjfg </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kekoa4/today_i_saw_an_ad_that_said_radio_for_sale_1/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kekoa4/today_i_saw_an_ad_that_said_radio_for_sale_1/">[comments]</a></span></p></li>
<li><strong>What has 27 actors, three settings, two writers, and one plot?</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
671 Hallmark movies.
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/JaxxisR"> /u/JaxxisR </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ke8wxq/what_has_27_actors_three_settings_two_writers_and/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ke8wxq/what_has_27_actors_three_settings_two_writers_and/">[comments]</a></span></p></li>
<li><strong>Two boys were misbehaving... ...so their mother went to the local priest to look for advice. The priest thought it would be best if the boys learned integrity, by way of understanding that "God is everywhere, and He sees everything you do so you shouldn't misbehave."</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
The mother and the priest thought it best that the priest talked to the boys, so the mother agreed to take the boys in one at a time to talk to the priest.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
She brought the first boy (Ray) to the church and left the second boy (Jim) at home. She took Ray into the priest's office and stayed outside while the priest and Ray talked.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
"Where is God?" The priest calmly asked expecting to make the point that "God is everywhere". Ray, petrified, said nothing. So the priest asked again slightly louder, "Where is God?!". Ray still said nothing. So the priest stood up and slammed his hands on the desk yelling, "WHERE IS GOD?!?!". Ray stood up and ran out of the office, past his mother, and ran all the way home.
</p>
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
He came screaming in the front door and ran straight to Jim's room. He opened the door and said, "GOD IS MISSING AND THEY THINK WE TOOK HIM!".
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MarkyChoco"> /u/MarkyChoco </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kerc55/two_boys_were_misbehaving_so_their_mother_went_to/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kerc55/two_boys_were_misbehaving_so_their_mother_went_to/">[comments]</a></span></p></li>
<li><strong>Boss: "You called in sick yesterday and said you had the Coronavirus. You can't be here until you get tested"</strong> - <!-- SC_OFF -->
<div class="md">
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
Me: "I said I had a case of Corona and I wasn't coming in to work. I never said anything about a virus"
</p>
</div>
<!-- SC_ON -->
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/jhutto2"> /u/jhutto2 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/kes5v5/boss_you_called_in_sick_yesterday_and_said_you/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/kes5v5/boss_you_called_in_sick_yesterday_and_said_you/">[comments]</a></span></p></li>
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@ -13,9 +13,9 @@ Archive | Daily Reports
<li> <a href="#covid-19">Covid-19</a>
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<h2 id="daily-dose">Daily Dose</h2>
<ul id="daily-dose-list"><li><a href="./archive-daily-dose/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-daily-dose/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-daily-dose/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-daily-dose/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-daily-dose/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-daily-dose/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-daily-dose/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-daily-dose/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-daily-dose/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
<ul id="daily-dose-list"><li><a href="./archive-daily-dose/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-daily-dose/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-daily-dose/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-daily-dose/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-daily-dose/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-daily-dose/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-daily-dose/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-daily-dose/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-daily-dose/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-daily-dose/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-daily-dose/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-daily-dose/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-daily-dose/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-daily-dose/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-daily-dose/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-daily-dose/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-daily-dose/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-daily-dose/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-daily-dose/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-daily-dose/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-daily-dose/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-daily-dose/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-daily-dose/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-daily-dose/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-daily-dose/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-daily-dose/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-daily-dose/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-daily-dose/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-daily-dose/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-daily-dose/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-daily-dose/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-daily-dose/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-daily-dose/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-daily-dose/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-daily-dose/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-daily-dose/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-daily-dose/11 November, 2020.html">11 November, 2020</a></li>
</ul>
<h2 id="covid-19">Covid-19</h2>
<ul id="covid-19-list"><li><a href="./archive-covid-19/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-covid-19/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-covid-19/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-covid-19/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-covid-19/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-covid-19/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-covid-19/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-covid-19/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-covid-19/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
<ul id="covid-19-list"><li><a href="./archive-covid-19/17 December, 2020.html">17 December, 2020</a></li><li><a href="./archive-covid-19/16 December, 2020.html">16 December, 2020</a></li><li><a href="./archive-covid-19/15 December, 2020.html">15 December, 2020</a></li><li><a href="./archive-covid-19/14 December, 2020.html">14 December, 2020</a></li><li><a href="./archive-covid-19/13 December, 2020.html">13 December, 2020</a></li><li><a href="./archive-covid-19/12 December, 2020.html">12 December, 2020</a></li><li><a href="./archive-covid-19/11 December, 2020.html">11 December, 2020</a></li><li><a href="./archive-covid-19/10 December, 2020.html">10 December, 2020</a></li><li><a href="./archive-covid-19/09 December, 2020.html">09 December, 2020</a></li><li><a href="./archive-covid-19/08 December, 2020.html">08 December, 2020</a></li><li><a href="./archive-covid-19/07 December, 2020.html">07 December, 2020</a></li><li><a href="./archive-covid-19/06 December, 2020.html">06 December, 2020</a></li><li><a href="./archive-covid-19/05 December, 2020.html">05 December, 2020</a></li><li><a href="./archive-covid-19/04 December, 2020.html">04 December, 2020</a></li><li><a href="./archive-covid-19/03 December, 2020.html">03 December, 2020</a></li><li><a href="./archive-covid-19/02 December, 2020.html">02 December, 2020</a></li><li><a href="./archive-covid-19/01 December, 2020.html">01 December, 2020</a></li><li><a href="./archive-covid-19/30 November, 2020.html">30 November, 2020</a></li><li><a href="./archive-covid-19/29 November, 2020.html">29 November, 2020</a></li><li><a href="./archive-covid-19/28 November, 2020.html">28 November, 2020</a></li><li><a href="./archive-covid-19/27 November, 2020.html">27 November, 2020</a></li><li><a href="./archive-covid-19/26 November, 2020.html">26 November, 2020</a></li><li><a href="./archive-covid-19/25 November, 2020.html">25 November, 2020</a></li><li><a href="./archive-covid-19/24 November, 2020.html">24 November, 2020</a></li><li><a href="./archive-covid-19/23 November, 2020.html">23 November, 2020</a></li><li><a href="./archive-covid-19/22 November, 2020.html">22 November, 2020</a></li><li><a href="./archive-covid-19/21 November, 2020.html">21 November, 2020</a></li><li><a href="./archive-covid-19/20 November, 2020.html">20 November, 2020</a></li><li><a href="./archive-covid-19/19 November, 2020.html">19 November, 2020</a></li><li><a href="./archive-covid-19/18 November, 2020.html">18 November, 2020</a></li><li><a href="./archive-covid-19/17 November, 2020.html">17 November, 2020</a></li><li><a href="./archive-covid-19/16 November, 2020.html">16 November, 2020</a></li><li><a href="./archive-covid-19/15 November, 2020.html">15 November, 2020</a></li><li><a href="./archive-covid-19/14 November, 2020.html">14 November, 2020</a></li><li><a href="./archive-covid-19/13 November, 2020.html">13 November, 2020</a></li><li><a href="./archive-covid-19/12 November, 2020.html">12 November, 2020</a></li><li><a href="./archive-covid-19/11 November, 2020.html">11 November, 2020</a></li>
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