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<meta content="width=device-width, initial-scale=1.0, user-scalable=yes" name="viewport"/>
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<title>27 February, 2021</title>
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<title>Daily-Dose</title><meta content="width=device-width, initial-scale=1.0" name="viewport"/><link href="styles/simple.css" rel="stylesheet"/><link href="../styles/simple.css" rel="stylesheet"/><style>*{overflow-x:hidden;}</style><link href="https://unpkg.com/aos@2.3.1/dist/aos.css" rel="stylesheet"/><script src="https://unpkg.com/aos@2.3.1/dist/aos.js"></script></head>
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<body>
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<h1 data-aos="fade-down" id="daily-dose">Daily-Dose</h1>
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<h1 data-aos="fade-right" data-aos-anchor-placement="top-bottom" id="contents">Contents</h1>
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<ul>
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<li><a href="#from-new-yorker">From New Yorker</a></li>
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<li><a href="#from-vox">From Vox</a></li>
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<li><a href="#from-the-hindu-sports">From The Hindu: Sports</a></li>
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<li><a href="#from-the-hindu-national-news">From The Hindu: National News</a></li>
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<li><a href="#from-bbc-europe">From BBC: Europe</a></li>
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<li><a href="#from-ars-technica">From Ars Technica</a></li>
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<li><a href="#from-jokes-subreddit">From Jokes Subreddit</a></li>
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</ul>
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<h1 data-aos="fade-right" id="from-new-yorker">From New Yorker</h1>
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<ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Good, the Bad, and the Embarrassing in America’s COVID-19 Response</strong> - Were Americans too unruly, or did elected officials expect too little of them? - <a href="https://www.newyorker.com/news/the-political-scene/the-good-the-bad-and-the-embarrassing-in-americas-covid-19-response">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Why Won’t Amnesty International Call Alexey Navalny a Prisoner of Conscience?</strong> - The Russian regime has used both its vast media infrastructure and its judicial system to vilify its opponents. - <a href="https://www.newyorker.com/news/our-columnists/why-wont-amnesty-international-call-alexey-navalny-a-prisoner-of-conscience">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Inside Xinjiang’s Prison State</strong> - Survivors detail the scope of China’s campaign of persecution against ethnic and religious minorities. - <a href="https://www.newyorker.com/news/a-reporter-at-large/china-xinjiang-prison-state-uighur-detention-camps-prisoner-testimony">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>On Climate, Wall Street Out-Orwells Orwell</strong> - BlackRock’s C.E.O. says divestment from fossil-fuel stocks would be “greenwashing.” - <a href="https://www.newyorker.com/news/annals-of-a-warming-planet/on-climate-wall-street-out-orwells-orwell">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>The Secret Life of the White House</strong> - The residence staff, many of whom have worked there for decades, balance their service of the First Family with their long-term loyalty to the house itself. - <a href="https://www.newyorker.com/news/the-political-scene/the-secret-life-of-the-white-house">link</a></p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-vox">From Vox</h1>
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<ul>
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<li><strong>The House passed Biden’s $1.9 trillion Covid-19 relief package</strong> -
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<figure>
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<img alt="Biden and Pelosi seated speaking in the Oval Office." src="https://cdn.vox-cdn.com/thumbor/uUSwH9vswZSqpIVh9fnH7LAGb-Y=/0x0:3339x2504/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68884080/1300522443.0.jpg"/>
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<figcaption>
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President Joe Biden and House Speaker Nancy Pelosi discuss the Covid-19 relief package in the Oval Office on February 5. | Stefani Reynolds/Getty Images
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</figcaption>
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</figure>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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Democrats’ sweeping pandemic stimulus package now heads to the Senate.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FnqdqI">
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Democrats have gotten over an important hurdle in <a href="https://www.vox.com/coronavirus-covid19">Covid-19</a> relief: The House of Representatives just passed its version of the <a href="https://www.vox.com/policy-and-politics/22276788/covid-relief-bill-congress-stimulus-checks">$1.9 trillion stimulus package</a>, sending it off to the Senate.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9zN18r">
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The bill passed around 2 a.m. on Saturday morning, in a 219-212 vote, with every Republican voting no. Democratic Reps. Jared Golden of Maine and Kurt Schrader of Oregon also opposed the bill.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="yuNy09">
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The bill includes some big-ticket items that would deliver important relief to businesses, workers, and the broader economy. It includes $1,400 stimulus checks for those making up to $75,000, $400 expanded weekly unemployment insurance benefits through August 29, and billions of dollars for arenas such as schools, state and local governments, and restaurants. It also <a href="https://www.vox.com/policy-and-politics/22287299/joe-biden-covid-19-stimulus-bill-obamacare-enrollment">increases Affordable Care Act subsidies</a> for low- and middle-income Americans and expands both the <a href="https://www.vox.com/future-perfect/2020/9/18/21444103/child-tax-credit-2020-joe-bden">child tax credit</a> and the earned income tax credit.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="WbdJlO">
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The bill also includes a $15 federal minimum wage, <a href="https://www.vox.com/2021/2/25/22299034/15-dollar-minimum-wage-senate-parliamentarian">though the provision is dead in the Senate</a>. The Senate parliamentarian ruled on Thursday evening that the minimum wage hike cannot be passed under the rules of budget reconciliation.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8O1peJ">
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In a <a href="https://www.majorityleader.gov/content/hoyer-statement-senate-parliamentarian-ruling-minimum-wage">statement</a> on Thursday, House Majority Leader Steny Hoyer (D-MD) said he is “deeply disappointed” in the ruling but noted that House Democrats will pass the bill as is, even though it will ultimately change in the Senate. “Gradually raising the minimum wage to $15 an hour remains a centerpiece of House Democrats’ economic plan and would provide a major boost in income to 27 million Americans while lifting nearly a million out of poverty,” he said.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ONOVOP">
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Senate Democrats are considering some workarounds on the minimum wage, though it’s unclear if they will stick.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="UOWDOc">
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Now that the House has passed a version of the bill, it will head to the Senate, which is likely to make some changes to the text. After that, it’s likely to get bounced back to the House, which would need to pass whatever the eventual agreed-on version of the legislation would be before it lands on President Joe Biden’s desk. The clock is ticking: Expanded and extended unemployment insurance <a href="https://www.vox.com/2020/12/21/22193134/covid-19-stimulus-deal-house-senate">under the last $900 billion stimulus package</a>, passed in December, ends on March 14. Democrats do not want to push workers off an unemployment cliff.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="EhKFE6">
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<a href="https://www.vox.com/policy-and-politics/22276788/covid-relief-bill-congress-stimulus-checks">You can find a complete look at what’s in the House bill here</a>.
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</p>
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<h3 id="NphIlb">
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Democrats are taking a big swing here
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</h3>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JtNxHp">
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Biden <a href="https://www.vox.com/policy-and-politics/22231808/joe-biden-economic-stimulus-proposal">first introduced</a> his proposal for a sweeping $1.9 trillion Covid-19 relief package in January, which the congressional plan largely mirrors. Democrats and many economists have for months argued that the risk on the federal government’s pandemic response is doing too little, not too much, to help the country and the economy. Many lawmakers feel the government undershot its response to the 2009 Great Recession and incorrectly assumed they’d have multiple chances at major legislation. They’re determined not to make that mistake this time around.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="2VafXk">
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“We can’t do too much here,” Biden told reporters in the Oval Office in early February. “We can do too little and sputter.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Me12jZ">
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Democrats, including the president, have argued that it’s an important moment for deficit spending to help people in need, also noting that interest rates are low and are expected to stay that way for quite some time. “Every major economist thinks we should be investing in deficit spending in order to generate economic growth,” Biden told reporters in January.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Sutq5k">
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To be sure, Democrats and the White House have received some pushback.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="iSBpLl">
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Republicans have broadly criticized the Democratic proposal.<strong> </strong>A group of 10 Senate Republicans put forth a counteroffer to Biden’s $1.9 trillion package, <a href="https://www.vox.com/22260255/senate-republicans-stimulus-plan">proposing instead a $600 billion bill</a> that would have addressed some immediate public health needs, such as vaccinations and testing, and food aid. But it shrank spending in areas such as unemployment, stimulus checks, and schools, and left out state and local aid altogether.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JWkmhc">
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Some economists who are more centrist or even Democratic have questioned whether the legislation is too ambitious. Larry Summers, an economist who served in both the Clinton and Obama administrations, wrote an <a href="https://www.washingtonpost.com/opinions/2021/02/04/larry-summers-biden-covid-stimulus/">op-ed warning</a> the bill might cause future inflation or make less politically palatable further stimulus. Summers’s concerns, while not out of left field, are not necessarily widely shared — <a href="https://www.vox.com/policy-and-politics/22268787/larry-summers-op-ed-biden-stimulus">many economists pointed out</a> that a little bit of inflation would indeed be good, and the Federal Reserve has tools to combat it.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wQFC5f">
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Before Summers’s op-ed was posted, Austan Goolsbee, another Obama economic alum, published an <a href="https://www.nytimes.com/2021/02/03/business/coronavirus-relief-spend-big.html">op-ed in the New York Times</a> warning that the country could fall into a double-dip recession, meaning the economy could get better and then fall again, and called for a proactive response from the federal government. He wrote that a “wait and see” approach on a relief program “has been proved to be deeply wrong since the pandemic began,” and noted that the virus has caused people to withdraw from the economy. “Much damage has already been done — and it is evident not only in lost jobs but in lost income and lost companies,” he wrote. “This harm could have been prevented. It definitely should not be repeated now.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="VYiiLa">
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There is plenty of space to debate what’s in the legislation, what should be there and what should not. Some provisions, such as higher ACA subsidies, the expanded child tax credit, and the expanded earned income tax credit, are only temporary, and it’s unclear whether they’ll last beyond the next year or two. The House bill cut off a month of expanded unemployment insurance, which Biden initially proposed extending through September. Democrats also <a href="https://www.vox.com/policy-and-politics/22277339/covid-19-relief-bill-automatic-stabilizers">opted against including automatic stabilizers in the bill</a>, which would tie supports such as unemployment insurance to economic conditions rather than arbitrary end dates.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jmeOdn">
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That the House has passed a version of the package doesn’t mean the process is over — there’s still quite a way to go before it lands in the Oval Office — but it’s an important step.
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</p></li>
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<li><strong>FDA advisers unanimously recommend Johnson & Johnson’s Covid-19 vaccine</strong> -
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<figure>
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<img alt="A view of the Johnson &amp; Johnson offices in Irvine, California, on October 23, 2020." src="https://cdn.vox-cdn.com/thumbor/QRdnmucBRIxReln5EEmGVtvHWhE=/317x0:2861x1908/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68739526/GettyImages_1229247259t.7.jpg"/>
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<figcaption>
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The Johnson & Johnson vaccine doesn’t require a booster shot, circumventing the two-dose problems posed by its competitors. The company plans to seek FDA approval in early February. | AaronP/Bauer-Griffin/GC Images/Getty Images
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</figcaption>
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</figure>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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The FDA could make an emergency use authorization as soon as this weekend, paving the way for distribution.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5Gj0Qk">
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A panel of expert advisers to the Food and Drug Administration (FDA) voted unanimously on Friday afternoon to recommend the one-dose <a href="https://www.vox.com/coronavirus-covid19">Covid-19</a> vaccine developed by Johnson & Johnson for an emergency use authorization. The next step is for the FDA to accept the recommendation, which could happen as soon as this weekend, clearing the way for distribution.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="gXGumE">
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Earlier this week, the <a href="https://www.fda.gov/media/146217/download">FDA posted a briefing</a> going over the results of the phase 3 clinical trials of the Johnson & Johnson vaccine, which included 40,000 participants in several countries divided randomly into placebo and treatment groups.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9w0K3c">
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The most important finding: The vaccine was 100 percent effective after 28 days at preventing deaths and hospitalizations from Covid-19 among the clinical trial participants who received the treatment. (Two vaccine recipients were hospitalized with Covid-19 two weeks after receiving the injection.)
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="h9stE4">
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The vaccine was also 66.1 percent effective at preventing symptomatic Covid-19 illness after four weeks, with consistent results across all age groups. When looking at blocking severe and critical cases of Covid-19, the Johnson & Johnson vaccine was 85.4 percent effective.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="ATlqPb">
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<a href="https://johnsonandjohnson.gcs-web.com/static-files/28c17ae4-9a10-4bd6-a022-1c829054c1e9">Mathai Mammen</a>, global head of research and development for Janssen Pharmaceutical Companies, said during a press conference last month that the vaccine also had “plain vanilla safety results,” with the vast majority of recipients experiencing no problems. Most of the reported symptoms were mild, including fatigue, arm pain, and fever.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="QGwRdt">
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The efficacy levels against severe to critical Covid-19 changed depending on where the vaccine was tested. It was 85.9 percent in the United States after four weeks, while in <a href="https://www.vox.com/2021/1/21/22240475/covid-new-variant-south-africa-uk-brazil-vaccine-coronavirus">South Africa, where a coronavirus variant</a> with worrisome mutations that help it escape vaccines has been spreading widely, efficacy against severe disease was reduced to 81.7 percent.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="amrxy4">
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Health officials say that while the Johnson & Johnson efficacy results are not as high as those from Moderna and Pfizer/BioNTech, the two vaccines that have already received emergency use authorizations from the FDA, the new vaccine’s performance is still superb.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="DW2SgN">
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“If this had occurred in the absence of a prior announcement and implementation of a 94, 95 percent efficacy [vaccine], one would have said this is an absolutely spectacular result,” said Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, during the press conference last month. The vaccine was developed by Janssen Pharmaceuticals, a division of Johnson & Johnson based in Belgium, together with Boston’s Beth Israel Deaconess Medical Center.
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8riTlR">
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But unlike the vaccines from Moderna and Pfizer/BioNTech,<strong> </strong>Johnson & Johnson’s doesn’t require a booster shot, circumventing the <a href="https://www.vox.com/coronavirus-covid19/22163315/covid-19-vaccines-doses-pfizer-moderna">two-dose problems</a> posed by its competitors. There’s no need to track people down for their second dose, which means more people could be vaccinated faster. The shots also don’t require deep-cold storage, which means they’re less costly and somewhat easier to distribute.
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“It’s a complete game changer,” said Georgetown University health law professor Lawrence Gostin. “It completely changes the equation.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="9aPn3E">
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The Johnson & Johnson vaccine is also different in another way. It uses an adenovirus vector to deliver instructions for making the spike protein of the coronavirus, which is also less expensive to manufacture than the mRNA platform used for the other vaccines. (It’s estimated to cost around <a href="https://www.reuters.com/article/uk-health-coronavirus-usa-johnsonandjohn-idUKKCN2511V7?edition-redirect=uk">$10 per vaccine dose</a> — roughly half the cost of the Pfizer/BioNTech vaccine.)
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Johnson & Johnson has promised enough vaccines for <a href="https://www.wsj.com/articles/johnson-and-johnson-covid-19-vaccine-fda-review-11614118867?mod=e2tw">20 million Americans</a> by the end of March and <a href="https://www.cnbc.com/2021/01/21/jj-plans-to-have-100-million-vaccines-for-americans-by-spring-board-member-says.html?utm_term=Autofeed&utm_medium=Social&utm_content=Main&utm_source=Twitter#Echobox=1611281085">100 million Americans</a> by the end of June despite <a href="https://www.politico.com/news/2021/01/13/johnson-johnson-vaccine-production-458941">production challenges</a>. It would be a huge boost to the <a href="https://www.npr.org/sections/health-shots/2021/01/28/960901166/how-is-the-covid-19-vaccination-campaign-going-in-your-state">65 million Covid-19 vaccine doses</a> that have been administered in the US so far.
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So even with an overall efficacy level that’s lower than the two other vaccines on the US market, the Johnson & Johnson vaccine could become a major player. It’s the vaccine that “can increase equity,” said <a href="https://medicine.yale.edu/yigh/profile/saad_omer/">Saad Omer</a>, the director of the Yale Institute for Global Health, particularly “if it’s deployed strategically in nations that are hard to reach and where that would be a particular challenge under a two-dose schedule.” Johnson & Johnson expects to distribute a billion doses of its vaccine worldwide this year.
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But as amazing as it is to see several effective Covid-19 vaccines developed in record time, it’s now clear that the technology alone won’t save the day. An orchestra of supply chains, manufacturing, logistics, staff, and public trust needs to harmonize in order to actually get billions of shots into arms around the world<strong> </strong>and finally draw the pandemic to a close. And we also have other hurdles to overcome: controlling the spread of variants that seem to be threatening the effectiveness of all the vaccines we have.
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</p>
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<h3 id="qigHwB">
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What we learned about the safety and efficacy of the Johnson & Johnson Covid-19 vaccine
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</h3>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="8kVugO">
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Johnson & Johnson launched <a href="https://www.jnj.com/johnson-johnson-initiates-pivotal-global-phase-3-clinical-trial-of-janssens-covid-19-vaccine-candidate">separate clinical trials</a> testing both a one-dose and a two-dose regimen to see how well these strategies provided long-term protection against Covid-19. The one-dose<strong> </strong>phase 3 trial <a href="https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial">arm yielded efficacy results first</a>.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="uxe3IK">
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But hints that this vaccine could be safe and effective have been trickling out for months. The company published some of its early phase 1 and phase 2 trial data in a preprint paper in September, and the final version of the paper in January, in the <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2034201"><em>New England Journal of Medicine</em></a>. The papers showed the vaccine was well tolerated among the participants, and seemingly very effective: With one dose, after 29 days, the vaccine ensured that 90 percent of participants had enough antibodies required to neutralize the virus. After 57 days, that number reached 100 percent.<strong> </strong>
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="FwPvyP">
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“When I looked at that, I thought, wow, this Johnson & Johnson product is very powerful after the first dose in terms of immunogenicity,” said <a href="https://medicine.ucsf.edu/people/monica-gandhi">Monica Gandhi</a>, a professor of global medicine at the University of California San Francisco. “The Pfizer and Moderna vaccines needed two doses to get that level of [virus] neutralization.”
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="m2SWyf">
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Like Pfizer/BioNTech, Johnson & Johnson “didn’t rush to phase 3 [trials],” said Hilda Bastian, a scientist who has been tracking the global vaccine race. Instead, it tested multiple vaccine doses and candidates at the outset to figure out which might perform the best in humans, and then proceeded through clinical trials.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="mMIcru">
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The vaccine was also tested in nine countries — the <a href="https://absolutelymaybe.plos.org/2020/09/30/meet-the-women-leading-vanguard-covid-19-vaccine-trials-a-sign-of-progress-reminder-of-whats-at-risk/">largest single international phase 3</a> trial in the world, with more than 60,000 participants — meaning many ethnic groups were represented in the data, Bastian said. “As if all that’s not enough, it’s one of the ones that could be manufactured in South Africa and other places,” since Johnson & Johnson has manufacturing capacity around the world, even in countries hard-hit by the pandemic that have been waiting for vaccine supplies, she added.
|
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="PWGN3q">
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The day this vaccine gets approval “is going to be a big day for the future of this pandemic [and] a ticket out of this disease for a larger part of the world,” said Nicholas Lusiani, a senior adviser at Oxfam America.
|
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</p>
|
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<h3 id="bnEG1Q">
|
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How adenovirus vector vaccines work
|
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</h3>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="IQfUn1">
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Part of the appeal of this vaccine lies in the technology behind it. <a href="https://www.cdc.gov/adenovirus/index.html">Adenoviruses</a> are a family of viruses that can cause a range of illnesses in humans, including the common cold. They’re very efficient at getting their DNA into a cell’s nucleus. Scientists reasoned that if they could snip out the right sections of an adenovirus’s genome and insert another piece of DNA code (in this case, for a fragment of the new coronavirus), they could have a powerful system to deliver instructions to cells.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="BetCdo">
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For decades, scientists have experimented with adenovirus vectors as a platform for <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507798/">gene therapy and to treat certain cancers</a>, using the virus to modify or replace genes in host cells. More recently, researchers have found success using adenoviruses as vaccines. Already, an adenovirus vector vaccine has been developed for the <a href="https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30515-6/fulltext">Ebola virus</a>.
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</p>
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="otHMyj">
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In addition to Johnson & Johnson and AstraZeneca/Oxford, CanSino Biologics of China is also developing an adenovirus vector Covid-19 vaccine; Russia’s <a href="https://sputnikvaccine.com/">Sputnik V</a> Covid-19 vaccine uses this platform, too.
|
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="tGLE8o">
|
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To make one of these vaccines, the adenovirus is modified so that it can’t reproduce but can carry the instructions for making a component of a virus. In the case of Covid-19, most adenovirus vector vaccines code for the spike protein of SARS-CoV-2, the part the virus uses to begin an infection.
|
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="larxQ5">
|
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Human cells then read those instructions delivered by the adenovirus and begin manufacturing the spike protein. The immune system recognizes the spike proteins as a threat and begins to build up its defenses.
|
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="Y2fwGf">
|
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Since adenoviruses exist naturally, they tend to be more temperature-stable than the synthetic lipid nanoparticles that are used to deliver the mRNA in the Moderna and Pfizer/BioNTech vaccines.
|
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|
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="nRyUnm">
|
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“The nice thing about the adenovirus vector vaccines is that they’re a little more tolerant to a longer shelf life, to the conditions of storage,” said <a href="https://ghss.georgetown.edu/people/angela-rasmussen/">Angela Rasmussen</a>, a virologist at Georgetown University. Adenovirus vector vaccines can be stored at refrigerator temperatures, while mRNA vaccines need freezers, with Pfizer/BioNTech’s vaccine requiring temperatures of minus 80 degrees Celsius.
|
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pDXKOK">
|
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|
This helps lower the cost and complexity of manufacturing, distribution, and administration of adenovirus vector vaccines compared to other platforms. And simply having another vaccine on the market,<strong> </strong>made by a major pharmaceutical company with its own manufacturing infrastructure, is a big step forward. “The more vaccine doses we can have, the better,” Rasmussen said.
|
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</p>
|
|||
|
|
<figure class="e-image">
|
|||
|
|
<img alt=" " src="https://cdn.vox-cdn.com/thumbor/aT8P1JW0Y1oGpRSRjCht9aYlsGw=/800x0/filters:no_upscale()/cdn.vox-cdn.com/uploads/chorus_asset/file/22267861/1230805815.jpg"/> <cite>Jason Redmond/AFP/Getty Images</cite>
|
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|
|
<figcaption>
|
|||
|
|
An Army National Guard specialist gives directions at one of four mass vaccination sites opened by the Washington state Department of Health on January 26.
|
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|
|
</figcaption>
|
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|
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</figure>
|
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|
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<h3 id="MmC52A">
|
|||
|
|
What comes next
|
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|
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</h3>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b3xwwQ">
|
|||
|
|
The next challenge for Johnson & Johnson, after getting a green light from the FDA, is actually delivering doses to millions of arms.
|
|||
|
|
</p>
|
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|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t6g1ey">
|
|||
|
|
But with three vaccines eventually on the market, should people hold out for any one vaccine in particular?
|
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|
|
</p>
|
|||
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="JY7JF4">
|
|||
|
|
“Right now when people ask me, which, you know, which vaccine should I get? It’s pretty easy to answer that question because it’s whichever one you get offered,” said <a href="https://physiciandirectory.brighamandwomens.org/details/1354/paul-sax-infectious_disease-internal_medicine-medicine-boston">Paul Sax</a>, a professor of medicine at Harvard Medical School. Vaccine supplies are limited, the transmission of the virus is high, and hospitals are close to capacity, so few people can be picky about what they get.
|
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</p>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="wIKdU7">
|
|||
|
|
On the other hand, once vaccine supplies stabilize, having multiple vaccines with different characteristics could allow doctors and public health officials to optimize how the shots are distributed. “If the efficacy [of a given vaccine] is lower but still pretty good, there may be a scenario that one vaccine is recommended for low-risk populations and another one is for a high-risk population,” Omer said.
|
|||
|
|
</p>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="f95Gyc">
|
|||
|
|
Though the Johnson & Johnson vaccine does have some key advantages over its competitors, it could face some of the same distribution snags that have hit other vaccines, like miscommunication between the government and hospitals, and production hurdles.
|
|||
|
|
</p>
|
|||
|
|
<aside id="oPwWhl">
|
|||
|
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<div>
|
|||
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|
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</div>
|
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</aside>
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="YLSHFW">
|
|||
|
|
Researchers say that all the manufacturers also need to start working to get vaccines to the rest of the world. The new variants that have emerged in the UK, Brazil, and South Africa and have been detected in other parts of the world are reminders that the virus continues to evolve, and that a partially vaccinated population could exert more selection pressures that accelerate <a href="https://www.vox.com/science-and-health/22247525/covid-19-variants-uk-south-africa-brazil-b117-why-now">these mutations</a>. So vaccination has to happen fast, and globally — and Johnson & Johnson’s vaccine may be a critical tool to do this.
|
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|
|
</p>
|
|||
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="pMN9D5">
|
|||
|
|
“Long term, we need to be thinking about getting vaccines out equitably to the entire world, and having vaccines that are easier to distribute in terms of the cold chain requirements is going to be huge in that regard,” Rasmussen said.
|
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|
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</p>
|
|||
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="rC1NxT">
|
|||
|
|
But even as these vaccines roll out, there’s still more to learn: how long protection from vaccines last, whether there are any rare complications to consider, whether they prevent transmission as well as disease, and how well these vaccines work against the new variants. There are already some troubling signs of how these variants might eventually be able to <a href="https://www.vox.com/science-and-health/22247525/covid-19-variants-uk-south-africa-brazil-b117-why-now">evade vaccines</a>. Continuing clinical trials will be critical, Sax said.
|
|||
|
|
</p>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="t4aitL">
|
|||
|
|
“You know, we’ve got millions of people who’ve received these vaccines already, which is exciting,” he added. “We’re on our way.”
|
|||
|
|
</p></li>
|
|||
|
|
<li><strong>This March, the Vox Book Club is going deep on gender, power, and corruption with The Power</strong> -
|
|||
|
|
<figure>
|
|||
|
|
<img alt="" src="https://cdn.vox-cdn.com/thumbor/bUt0r3Rat0eW6K3xdoOISxbvnME=/0x1004:1651x2242/1310x983/cdn.vox-cdn.com/uploads/chorus_image/image/68882489/81siXD4WNiL.0.jpg"/>
|
|||
|
|
<figcaption>
|
|||
|
|
The Power by Naomi Alderman | Back Bay Books
|
|||
|
|
</figcaption>
|
|||
|
|
</figure>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
|||
|
|
Read along with us as we delve into Naomi Alderman’s award-winning dystopia.
|
|||
|
|
</p>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="b4yZbU">
|
|||
|
|
<em>The Vox Book Club is linking to </em><a href="https://go.redirectingat.com/?id=66960X1516588&xs=1&url=https://bookshop.org/shop/voxbookclub&referrer=vox.com&sref=https://www.vox.com/culture/21423100/idiot-elif-batuman-semiotics-language-word-games&xcust=___vx__p_22020487__t_w__r_vox.com/vox-book-club__d" rel="sponsored nofollow noopener" target="_blank"><em><strong>Bookshop.org</strong></em></a><em> to support local and independent booksellers.</em>
|
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|
|
</p>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="jIw1e2">
|
|||
|
|
As we head into March, the United States enters its first-ever <a href="https://womenshistorymonth.gov/">Women’s History month</a> with a woman serving as vice president. Kamala Harris is now officially in office, and we have been given a month to think about the history of women in America — four years after a man who was caught on tape bragging about sexually assaulting women defeated the first major-party woman candidate for the presidency.
|
|||
|
|
</p>
|
|||
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="E6lEqE">
|
|||
|
|
So this March, in particular, is an interesting time to consider institutional power, the ways in which women have historically had very little of it, and what our world might look like if and when that changes. That’s why the Vox Book Club will spend the month reading Naomi Alderman’s <a href="https://go.redirectingat.com?id=66960X1516588&xs=1&url=https%3A%2F%2Fbookshop.org%2Fbooks%2Fthe-power%2F9780316547604&referrer=vox.com&sref=https%3A%2F%2Fwww.vox.com%2Fculture%2F22299751%2Fpower-naomi-alderman-vox-book-club" rel="sponsored nofollow noopener" target="_blank"><em>The Power</em></a>.
|
|||
|
|
</p>
|
|||
|
|
<aside id="iAu08S">
|
|||
|
|
<div>
|
|||
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|
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</div>
|
|||
|
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</aside>
|
|||
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="7ASjla">
|
|||
|
|
In <em>The Power</em>, Alderman, who is a protégé of Margaret Atwood’s, imagines a universe in which women en masse develop a genetic mutation that allows them to electrocute people. The balance of power between the sexes abruptly stutters and shifts, and the world begins to reshape itself on a fundamental level. The result is an exploration of the ways we gender power and of power itself and all the ways it corrupts and can be abused.
|
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|
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</p>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="eXAfht">
|
|||
|
|
We’ll have tons to talk about together, and at the end of the month, we’ll discuss the book with Alderman herself, live on Zoom. <a href="https://voxbookclub-march.splashthat.com/">You can RSVP to join us here</a>.
|
|||
|
|
</p>
|
|||
|
|
<h3 id="m4zBIo">
|
|||
|
|
<strong>Here’s the full </strong><a href="https://www.vox.com/2020/4/10/21216559/vox-book-club-join-read-discuss"><strong>Vox Book Club schedule</strong></a><strong> for March 2021</strong>
|
|||
|
|
</h3>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="0KiLCN">
|
|||
|
|
<strong>Friday, March 12:</strong> Discussion post on <em>The Power </em>published to Vox.com
|
|||
|
|
</p>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="dVc7Yl">
|
|||
|
|
<strong>Thursday, March 25:</strong> Virtual live event with author Naomi Alderman at 12 pm Eastern. <a href="https://voxbookclub-march.splashthat.com/">RSVP here</a>.
|
|||
|
|
</p>
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="xrW31Y">
|
|||
|
|
<a href="https://confirmsubscription.com/h/d/533DCA62F59CA120"><strong>Subscribe to the Vox Book Club newsletter to stay up to date on all the books we’re reading.</strong></a>
|
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|
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</p>
|
|||
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom" id="5LPqIK">
|
|||
|
|
</p></li>
|
|||
|
|
</ul>
|
|||
|
|
<h1 data-aos="fade-right" id="from-the-hindu-sports">From The Hindu: Sports</h1>
|
|||
|
|
<ul>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>New Zealand moves men’s and women’s T20Is to Wellington as Auckland goes into lockdown</strong> - Both the matches will now be held behind closed doors</p></li>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Women’s squad vs South Africa: Shikha Pandey axed, rookie keeper Shwetha gets maiden call-up</strong> - Mithali Raj and Harmanpreet Kaur will lead the ODI and T20I teams respectively</p></li>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Bumrah released from Indian Test squad due to personal reasons</strong> - Ahmedabad Fast bowler Jasprit Bumrah was on Saturday released from India’s squad for the fourth Test against England, beginning here on Thursday, due</p></li>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>More India is allowed to get away, more toothless ICC will look, says Vaughan</strong> - Vaughan called India’s win “a shallow victory” but admitted that the home team is much better equipped to deal with the conditions.</p></li>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>West Indies recall Chris Gayle, Fidel Edwards for Sri Lanka T20 series</strong> - Former captain Gayle last played for West Indies in a one-day international against India in 2019</p></li>
|
|||
|
|
</ul>
|
|||
|
|
<h1 data-aos="fade-right" id="from-the-hindu-national-news">From The Hindu: National News</h1>
|
|||
|
|
<ul>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus | Cabinet Secretary reviews surge in COVID-19 cases</strong> - Enforce pandemic-appropriate behaviour and deal firmly with violations, States told</p></li>
|
|||
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Coronavirus | Eight States displaying upward trajectory in daily new cases, says Health Ministry</strong> - Maharashtra shows highest rise, Kerala biggest decline in the last two weeks.</p></li>
|
|||
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>NIA files supplementary charge sheet against four human traffickers of Jharkhand</strong> - They used to traffic poor and innocent minor boys and girls from Jharkhand on the pretext of providing them jobs in Delhi and neighbouring States, the official said.</p></li>
|
|||
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>ED attaches ₹84-crore assets in SKSCCL case</strong> - The ED probe is based on a complaint from the Office of the Registrar Cooperative Societies, Bengaluru and various FIRs</p></li>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Congress dissenters pitch for Ghulam Nabi Azad at Jammu meet</strong> - Ghulam Nabi Azad, who is heading the Congress camp, said his party respect all religions, people and castes.</p></li>
|
|||
|
|
</ul>
|
|||
|
|
<h1 data-aos="fade-right" id="from-bbc-europe">From BBC: Europe</h1>
|
|||
|
|
<ul>
|
|||
|
|
<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Lockdown bomb hoaxer targeted NHS, MPs and BLM protests</strong> - A German court imprisons a Berlin-based Italian for extortion threats made against UK targets.</p></li>
|
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Alexei Navalny: Top Putin critic sent to Russian penal colony</strong> - Alexei Navalny’s conviction for embezzlement is widely seen as politically motivated.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Mary Robinson ‘made a big mistake’ over Dubai princess</strong> - Princess Latifa Al Maktoum was previously described as “troubled” by the former Irish president.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Cork farm murders: Investigation after brothers’ bodies found</strong> - Gardaí investigating a double murder of two brothers in County Cork find the body of a third man.</p></li>
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<li data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Michael Collins’ wolf slippers spark Twitter storm</strong> - The emergence of the Irish revolutionary’s bright blue plush puppies stunned Irish Twitter users.</p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-ars-technica">From Ars Technica</h1>
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<ul>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Perseverance’s eyes see a different Mars</strong> - The Red Planet’s red looks different to a robot with hyperspectral cameras for eyes. - <a href="https://arstechnica.com/?p=1745740">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hackers tied to Russia’s GRU targeted the US grid for years</strong> - Sandworm-aligned group has breached US critical infrastructure a handful of times - <a href="https://arstechnica.com/?p=1745731">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>FDA panel votes unanimously in favor of authorizing J&J vaccine</strong> - The vaccine could be authorized as soon as Saturday. - <a href="https://arstechnica.com/?p=1745814">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>Hard-coded key vulnerability in Logix PLCs has severity score of 10 out of 10</strong> - Critical authentication bypass flaw affects the entire Logix product line. - <a href="https://arstechnica.com/?p=1745776">link</a></p></li>
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<li><p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"><strong>TikTok agrees to proposed $92 million settlement in privacy class action</strong> - Class members can get compensation, as long as most don’t file for it. - <a href="https://arstechnica.com/?p=1745503">link</a></p></li>
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</ul>
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<h1 data-aos="fade-right" id="from-jokes-subreddit">From Jokes Subreddit</h1>
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<ul>
|
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<li><strong>My girlfriend broke up with me for being too “un-American”</strong> - <!-- SC_OFF -->
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<div class="md">
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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I saw it coming from a kilometre away
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</p>
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</div>
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<!-- SC_ON -->
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/MrGupppy"> /u/MrGupppy </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ltkeo3/my_girlfriend_broke_up_with_me_for_being_too/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ltkeo3/my_girlfriend_broke_up_with_me_for_being_too/">[comments]</a></span></p></li>
|
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<li><strong>What’s the difference between me and cancer?</strong> - <!-- SC_OFF -->
|
|||
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<div class="md">
|
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
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|
My dad didn’t beat cancer.
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</p>
|
|||
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|
</div>
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<!-- SC_ON -->
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|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/Chainsmoker88"> /u/Chainsmoker88 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lt5nin/whats_the_difference_between_me_and_cancer/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lt5nin/whats_the_difference_between_me_and_cancer/">[comments]</a></span></p></li>
|
|||
|
|
<li><strong>Today at the gym, i asked a girl what her new year’s resolution was</strong> - <!-- SC_OFF -->
|
|||
|
|
<div class="md">
|
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|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
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|
She said ‘’Fuck you’’
|
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|
</p>
|
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|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
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|
|
|
|||
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|
</p>
|
|||
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<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
|||
|
|
so i’m pretty excited for 2022
|
|||
|
|
</p>
|
|||
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|
</div>
|
|||
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|
<!-- SC_ON -->
|
|||
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|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/suave111111"> /u/suave111111 </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lszz72/today_at_the_gym_i_asked_a_girl_what_her_new/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lszz72/today_at_the_gym_i_asked_a_girl_what_her_new/">[comments]</a></span></p></li>
|
|||
|
|
<li><strong>My wife emailed me our wedding photos, but I couldn’t open any of the files.</strong> - <!-- SC_OFF -->
|
|||
|
|
<div class="md">
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
|||
|
|
I always have trouble with emotional attachments.
|
|||
|
|
</p>
|
|||
|
|
</div>
|
|||
|
|
<!-- SC_ON -->
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/porichoygupto"> /u/porichoygupto </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/ltegww/my_wife_emailed_me_our_wedding_photos_but_i/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/ltegww/my_wife_emailed_me_our_wedding_photos_but_i/">[comments]</a></span></p></li>
|
|||
|
|
<li><strong>My girlfriend said I’m terrible in bed</strong> - <!-- SC_OFF -->
|
|||
|
|
<div class="md">
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom">
|
|||
|
|
But it’s unfair to make a conclusion in 17 seconds
|
|||
|
|
</p>
|
|||
|
|
</div>
|
|||
|
|
<!-- SC_ON -->
|
|||
|
|
<p data-aos="fade-left" data-aos-anchor-placement="bottom-bottom"> submitted by <a href="https://www.reddit.com/user/AnInsaneMoose"> /u/AnInsaneMoose </a> <br/> <span><a href="https://www.reddit.com/r/Jokes/comments/lstjc8/my_girlfriend_said_im_terrible_in_bed/">[link]</a></span> <span><a href="https://www.reddit.com/r/Jokes/comments/lstjc8/my_girlfriend_said_im_terrible_in_bed/">[comments]</a></span></p></li>
|
|||
|
|
</ul>
|
|||
|
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|
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